For Organic Compound Patents (Class 205/787)
  • Patent number: 11846601
    Abstract: A method of testing a gas includes providing a sensor including a sensing electrode that includes a catalyst comprising palladium, and a counter electrode that includes a metal catalyst. An electrolyte is disposed between the sensing electrode and the counter electrode, and an external electrical circuit connects the sensing electrode and the counter electrode. The gas is contacted with the sensing electrode in the absence of a voltage bias applied to the sensing and counter electrodes. A capacitive response is detected that is produced by the exposure of the sensing electrode to the gas in the absence of a voltage bias applied to the sensing and counter electrodes.
    Type: Grant
    Filed: May 10, 2018
    Date of Patent: December 19, 2023
    Assignee: CARRIER CORPORATION
    Inventors: Zhiwei Yang, Lei Chen
  • Patent number: 11138766
    Abstract: The method of the invention expresses an image with colors by creating a color expression drawing that corresponds to the image to be visualized, wherein: in a first step, n subject(s) each select(s), from among a color sample group that includes color samples including A×B types of color samples, S types of color samples that correspond to the image, and assign(s) a contribution degree for each of the selected color samples; in a second step, an expression chart of each of the n subject(s) is created using the contribution degrees assigned and the color samples of the color sample group; in a third step, for each samples, the contribution degree(s) included in the expression chart(s) of the n subject(s) are summed, thereby obtaining the sums of the contribution degrees of the n subject(s) for the respective color samples, where A, B, S?2, and n?1.
    Type: Grant
    Filed: November 6, 2019
    Date of Patent: October 5, 2021
    Assignee: T. HASEGAWA CO., LTD.
    Inventors: Kensuke Nojiri, Atsushi Nakamura, Mengning Qian
  • Patent number: 11067555
    Abstract: A detection system (101, 101b) of enteric diseases in animals includes a sensor device (102) having suction (103) for suctioning air from the animals' environment (11, 12). A sensor is (104) configured to determine information about the type and concentration of smelling molecules in the air and further configured to emit a signal representative of the information of smelling molecules. A transmission device (105) is configured to convey the signal representative of smelling molecules. A self-learning processing device (108) is configured to receive and process the signal representative of smelling molecules, and to detect a risk of enteric diseases in the animals associated with the information about the type and concentration of the smelling molecules. A signaling device (111) is configured to report to a user (10) the risk of enteric diseases in the animals, before the enteric diseases arise. A relative method detects enteric diseases in animals.
    Type: Grant
    Filed: June 8, 2017
    Date of Patent: July 20, 2021
    Assignee: UNIVERSITA' DEGLI STUDI DI MILANO
    Inventors: Marcella Guarino, Valentina Ferrante, Guido Grilli, Federica Borgonovo, Lorenzo Ferrari, Andrea Giovanni Pastori, Ilaria Fontana, Emanuela Tullo, Paolo Guffanti
  • Patent number: 11041247
    Abstract: The invention provides methods for direct growth of low noise, atomically thin freestanding membranes of two-dimensional monocrystalline or polycrystalline materials, such as transition metal chalcogenides including molybdenum disulfide. The freestanding membranes are directly grown over an aperture by reacting two precursors in a chemical vapor deposition process carried out at atmospheric pressure. Membrane growth is preferentially over apertures in a thin sheet of solid state material. The resulting membranes are one or a few atomic layers thick and essentially free of defects. The membranes are useful for sequencing of biopolymers through nanopores.
    Type: Grant
    Filed: February 4, 2020
    Date of Patent: June 22, 2021
    Assignee: Northeastern University
    Inventors: Pradeep Waduge, Swastik Kar, Meni Wanunu, Joseph Larkin, Ismail Bilgin
  • Patent number: 10905788
    Abstract: Disclosed herein is a scent-emanating apparatus including a discharging mechanism which permits a scent substance perceivable by a user together with a marker substance for detection to be discharged outwards, and a sensor to detect the marker substance discharged from the discharging mechanism.
    Type: Grant
    Filed: July 29, 2016
    Date of Patent: February 2, 2021
    Assignee: SONY INTERACTIVE ENTERTAINMENT INC.
    Inventors: Yoichi Nishimaki, Shinichi Hirata, Yuichi Machida, Kazuo Miura
  • Patent number: 10816519
    Abstract: An odor analysis system is provided to analyze odors present at a particular location and perform a preliminary identification of the odors while still at the location. The odor analysis system can have an odor processing device that collects samples of the odors and provides a series of odor notes to a user. The odor notes can be based on the separated and concentrated molecules in the collected sample. The odor analysis system can also include a hand-held computing device with a user interface that permits the user to enter information, both verbally and through touch input, about the series of odor notes provided by the odor processing device. The information entered by the user about the series of odor notes along with retention index information about the series of odor notes can be to perform a preliminarily identification of the molecules associated with the odors present at the location.
    Type: Grant
    Filed: July 18, 2018
    Date of Patent: October 27, 2020
    Assignee: Volatile Analysis Corporation
    Inventors: Russell A. Bazemore, Katherine Bazemore, Chris P. Christenson, Mitchell R. White
  • Patent number: 10197498
    Abstract: Disclosed herein sensor matrices comprising nanofibers and one or more sensor components, wherein the one or more sensor components detect an analyte. In addition, methods of making and detecting the sensor matrices are disclosed. For example, a nanofiber with a shell and coaxial core may be made with a sensor in the shell.
    Type: Grant
    Filed: October 21, 2014
    Date of Patent: February 5, 2019
    Assignee: Northeastern University
    Inventors: Timothy T. Ruckh, Mary K. Balaconis, Heather A. Clark, Christopher Skipwith
  • Patent number: 9885075
    Abstract: The present invention concerns a method of detecting macroions in a liquid medium contained in a space, the method including: a) submitting the liquid medium to a stimulating electrical field to induce formation of aggregates of macroions, the formed aggregates of macroions preferably not including any additional labeling agent, and b) measuring, in a detection zone of the space, spatial and/or temporal fluctuations within the liquid medium of at least one variable depending on the concentration of the macroions in the liquid medium, and c) determining, based on these fluctuations, the presence of the macroions, step c) preferably including processing by a time-dependent or space dependent analysis, more preferably by wavelet analysis, or by autocorrelation the fluctuations measured at step b).
    Type: Grant
    Filed: July 2, 2013
    Date of Patent: February 6, 2018
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSTITUT CURIE, UNIVERSITE PIERRE ET MARIE CURIE
    Inventors: Jean-Louis Viovy, François Amblard, Laurent Malaquin, Bastien Venzac, Mohamed Lemine Diakite, Stephanie Descroix, Ismaïl Cisse, Ulrich Bockelmann
  • Patent number: 9453813
    Abstract: An electrochemical test sensor for detecting the analyte concentration of a fluid test sample includes a base, a dielectric layer, a reagent layer, a light guide area, and a lid. The base provides a flow path for the test sample having on its surface a counter electrode and a working electrode adapted to electrically communicate with a detector of electrical current. The dielectric layer forms a dielectric window therethrough. The reagent layer includes an enzyme that is adapted to react with the analyte. The lid is adapted to mate with the base and to assist in forming a capillary space with an opening for the introduction of the test sample thereto. The light guide area transmits light towards the capillary space.
    Type: Grant
    Filed: July 15, 2014
    Date of Patent: September 27, 2016
    Assignee: Ascensia Diabeties Care Holdings AG
    Inventors: Allen J. Brenneman, Dan O'Sullivan
  • Patent number: 9410913
    Abstract: Methods and systems for measuring and using the oxidation-reduction characteristics of a biological sample are provided. The system generally includes a test strip and a readout device. A fluid sample is placed in the test strip, and the test strip is in turn operatively connected to the readout device. The readout device provides a controlled current that is sent across the fluid in the sample chamber. In addition, the readout device identifies an inflection point or transition time at which the voltage between contacts of the test strip is changing at the highest rate. The oxidation-reduction capacity of the sample is taken as the integral of the current profile from the time at which current begins to be supplied to the sample to the identified transition time.
    Type: Grant
    Filed: October 23, 2013
    Date of Patent: August 9, 2016
    Assignee: AYTU BIOSCIENCE, INC.
    Inventors: Raphael Bar-Or, David Bar-Or, Leonard T. Rael
  • Patent number: 9364174
    Abstract: Techniques for monitoring a target analyte in a sample using a polymer capable of binding to the target analyte are disclosed. A microdevice useful for the disclosed techniques includes a semi-permeable membrane structure, a substrate, a first and second microchambers formed between the membrane structure and the substrate. The first microchamber can be adapted to receive a solution including the polymer, and the second microchamber can be adapted to receive a reference solution. Environmental target analyte can permeate the semi-permeable membrane structure and enters the first microchamber and the second microchamber. Based on the difference in a property associated with the polymer solution that is responsive to the target analyte-polymer binding, and the corresponding property associated with reference solution, the presence and/or concentration of the target analyte can be determined.
    Type: Grant
    Filed: January 21, 2014
    Date of Patent: June 14, 2016
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Qiao Lin, Xian Huang
  • Patent number: 9279792
    Abstract: A method of using an absorptive sensor element includes: providing the absorptive sensor element, heating the absorptive sensor element to a temperature in a range of from 30° C. to 100° C., exposing the absorptive sensor element to an analyte vapor, and measuring a capacitance-related property of the absorptive sensor element and/or a spectral feature upon reflection of incident light. The absorptive sensor element comprises: a substrate, a first member disposed on the substrate, a second member, and a detection layer comprising a polymer of intrinsic microporosity disposed between and contacting the first member and the second member.
    Type: Grant
    Filed: March 27, 2012
    Date of Patent: March 8, 2016
    Assignee: 3M Innovative Properties Company
    Inventors: Michael C. Palazzotto, Stefan H. Gryska, Myungchan Kang, Michael S. Wendland
  • Patent number: 9231263
    Abstract: A system and method that monitor the rate of a voltage drop of fuel cells in a fuel cell stack to determine whether the voltage drop is a result of cathode reactant starvation or anode reactant starvation. The method looks at a falling voltage of a fuel cell to determine whether the rate of the fall in voltage indicates that hydrogen starvation of the anode of the fuel cell is occurring. The method also looks at the actual voltage of the fuel cell that is falling to determine whether it is a below a predetermined minimum voltage threshold also indicating that hydrogen starvation of the anode of the fuel cell is occurring. If hydrogen starvation is occurring, the method performs power limiting of the fuel cell stack either based on the rate or the voltage level.
    Type: Grant
    Filed: January 21, 2013
    Date of Patent: January 5, 2016
    Assignee: GM Global Technology Operations LLC
    Inventors: Derek R. Lebzelter, Balasubramanian Lakshmanan, Sriram Ganapathy, Sanja Sljivar-Lovria, Bruce J. Clingerman, Michael J. Kiefer
  • Patent number: 9096430
    Abstract: The present invention includes methods, compositions and kits for analyzing a chemical analyte having an electrochemical cell connected to a measuring apparatus. The electrochemical cell contains a solution having one or more nanoparticles, one or more chemical analytes, an indicator. In addition, the electrochemical cell contains one or more electrodes in communication with the solution. One or more electrocatalytic properties are generated by the interaction of the one or more nanoparticles and the liquid sample and measured at the one or more electrodes.
    Type: Grant
    Filed: June 13, 2008
    Date of Patent: August 4, 2015
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Xiaoyin Xiao, Allen J. Bard, Fu-Ren F. Fan
  • Patent number: 9034171
    Abstract: Systems and methods for implementing an automated process which calculates the current specific gravity of a liquid by using the original gravity of a fermenting liquid and a measurement of the percent alcohol by volume.
    Type: Grant
    Filed: March 7, 2014
    Date of Patent: May 19, 2015
    Assignee: Alcotek, Inc.
    Inventors: John Mitchell, Karl R. Wolf, Jr., Patrick Clifford
  • Publication number: 20150129435
    Abstract: An apparatus is disclosed for measuring the total organic content of an aqueous stream. The apparatus comprises a platinum electrode for measuring CO2 in an aqueous stream. Methods for measuring the total organic content of an aqueous stream are also disclosed. The methods comprise providing an aqueous stream with oxidized organics therein; providing a platinum electrode, contacting the aqueous stream with the platinum electrode; applying cathodic potential followed by an anodic voltammetric sweep to the platinum electrode, and measuring the amperometric response of the platinum electrode. An apparatus for oxidizing organics in aqueous stream in an aqueous stream is also disclosed.
    Type: Application
    Filed: December 14, 2012
    Publication date: May 14, 2015
    Inventors: Krzysztof Franaszczuk, Mariem-Ruth Rosario-Canales
  • Patent number: 9005426
    Abstract: Described are methods and systems to apply a plurality of test voltages to the test strip and measure at least a current transient output resulting from an electrochemical reaction in a test chamber of the test strip so that a glucose concentration can be determined that are generally insensitive to other substances in the body fluid sample that could affect the precision and accuracy of the glucose concentration.
    Type: Grant
    Filed: September 28, 2012
    Date of Patent: April 14, 2015
    Assignee: Cilag GmbH International
    Inventor: Michael Malecha
  • Patent number: 8945370
    Abstract: An electrochemical method for capsaicinoid and/or related compound detection in a sample by way of a screen printed electrode having a working electrode, a reference electrode, and a counter electrode. The working electrode can be screen-printed using conductive carbon ink; the reference electrode can be screen printed using conductive carbon ink; and the counter electrode can be screen printed using silver/silver chloride. The method includes contacting the electrode with the sample in the presence of electrolyte solution, and determining whether a change in redox potential occurs by way of differential pulse voltammetry, wherein a modulation amplitude is between approximately 0.1 volt/min and approximately 2.0 volt/min, a step potential is between approximately 0.0005 volt and approximately 0.01 volt, a modulation time is 0.05 seconds, and a corresponding interval time is approximately 0.5 second.
    Type: Grant
    Filed: March 30, 2012
    Date of Patent: February 3, 2015
    Assignee: Agricultural Research Development Agency
    Inventors: Werasak Surareungchai, Chatuporn Phanthong
  • Patent number: 8877038
    Abstract: The invention provides an electrochemical assay for a phenol analyte in a body fluid sample wherein said sample, or fluid therefrom, is contacted with the working electrode of an electrode assembly comprising a working electrode, a counter-electrode, a voltage supply to said working and counter-electrodes and a current meter for determining the current between said working and counter-electrodes, and wherein a first compound capable of reversible oxidation and reduction is disposed at said working electrode, said first compound being capable in either an oxidized or a reduced form of binding to said phenol analyte, characterized in that said first compound in its oxidized or reduced form comprises a group of structure I R1-NH—C*—(C*—C*)n—C*-QR? (I) (where n is 0 or 1; Q is 0, S, NH or NR?; C*—(C*—C*)n—C* is a two or four carbon string in a conjugated delocalised electron system optionally substituted by a group comprising R; R is an electron-donating or withdrawing substituent; and R? is H or a group R, at le
    Type: Grant
    Filed: April 24, 2009
    Date of Patent: November 4, 2014
    Assignee: Oxtox Limited
    Inventors: Dimitrios Konstantinos Kampouris, Rashid Olukayoee Kadara, Patrick Robinson Huddleston, Craig Edward Banks
  • Publication number: 20140305811
    Abstract: The present invention provides compositions and methods directed to an electrode initialization step for the electrochemical treatment of monolayers used in electrochemical detection of target analytes on the surface of a monolayer. Electrode initialization creates a more stable monolayer, and resolves variability within the electrochemical signal detected on the monolayer.
    Type: Application
    Filed: March 12, 2014
    Publication date: October 16, 2014
    Applicant: GenMark Diagnostics, Inc.
    Inventors: Jon Faiz Kayyem, Ken Rusterholz, William Bender, Sean Ford, Claudia C. Argueta
  • Patent number: 8858780
    Abstract: A method of determining an analyte concentration employs a biosensor that includes a molecularly imprinted polymer film formed on a metal layer. The biosensor is connected to a charge/discharge circuit and charged and discharged during exposure to a solution containing an analyte. Voltage values during discharge are measured, and a characteristic parameter of the voltage values, which is associated with a concentration of the analyte detected by the biosensor, is determined. An unknown concentration of the analyte is determined by comparing the characteristic parameter to reference data representing a relation between known concentration of the analyte and the characteristic parameter of the biosensor. A biosensor, such as an anesthetic biosensor, is also disclosed.
    Type: Grant
    Filed: November 21, 2011
    Date of Patent: October 14, 2014
    Assignee: National Tsing Hua University
    Inventors: Chien-Chong Hong, Meng-Hua Chung, Chih-Chung Lin
  • Publication number: 20140291170
    Abstract: Provided herein are methods, apparatuses, and systems for enhancing the detection of reactive gases, such as ethylene gas, that are present at low concentrations in air samples. The methods and systems enhance the selectivity, sensitivity, and accuracy of electrochemical cells by removing interfering gases from the air samples. Some systems include an ethylene sensor that includes an electrochemical cell and a polar solvent gas trap pre-filter, wherein the gas trap is positioned upstream of the electrochemical cell. Some methods are methods of measuring an ethylene level in an air sample, and include passing the air sample by through a polar solvent gas trap, and measuring the ethylene level in the air sample with an electrochemical cell.
    Type: Application
    Filed: February 20, 2014
    Publication date: October 2, 2014
    Applicant: CID Bio-Science, Inc.
    Inventors: James R. Goecks, Ryan M. Lerud
  • Publication number: 20140251835
    Abstract: Systems and methods for implementing an automated process which calculates the current specific gravity of a liquid by using the original gravity of a fermenting liquid and a measurement of the percent alcohol by volume.
    Type: Application
    Filed: March 7, 2014
    Publication date: September 11, 2014
    Applicant: Alcotek, Inc.
    Inventors: John Mitchell, Karl R. Wolf, JR., Patrick Clifford
  • Publication number: 20140251832
    Abstract: An electrochemical assay uses paramagnetic particles (10) including a coating of electroactive material (12) in order to detect or measure an analyte (30) of interest. The analyte is brought within the vicinity of an electrode (42) along with the coated paramagnetic particles (10). Application of a potential converts the electroactive coating (12) on the paramagnetic particles (10) into ions that can be measured using, for example, anodic stripping voltammetry. The level of ions corresponds to the amount of analyte of interest in the sample.
    Type: Application
    Filed: October 22, 2012
    Publication date: September 11, 2014
    Inventor: Robert Andrew Porter
  • Publication number: 20140154811
    Abstract: Technologies are generally described for gas filtration and detection devices. Example devices may include a graphene membrane and a sensing device. The graphene membrane may be perforated with a plurality of discrete pores having a size-selective to enable one or more molecules to pass through the pores. A sensing device may be attached to a supporting permeable substrate and coupled with the graphene membrane. A fluid mixture including two or more molecules may be exposed to the graphene membrane. Molecules having a smaller diameter than the discrete pores may be directed through the graphene pores, and may be detected by the sensing device. Molecules having a larger size than the discrete pores may be prevented from crossing the graphene membrane. The sensing device may be configured to identify a presence of a selected molecule within the mixture without interference from contaminating factors.
    Type: Application
    Filed: November 30, 2012
    Publication date: June 5, 2014
    Inventors: Angele Sjong, Kraig Anderson, Gary L. Duerksen, Seth Adrian Miller
  • Patent number: 8668821
    Abstract: According to the present invention, phenols may be detected using an electrochemical sensor comprising a first compound, a working electrode and an electrolyte in contact with the working electrode, wherein the first compound operatively undergoes a redox reaction at the working electrode to form a second compound which operatively reacts in situ with the phenol, wherein said redox reaction has a detectable redox couple and wherein the sensor is adapted to determine the electrochemical response of the working electrode to the consumption of said second compound on reaction with the phenol. The phenol may be, for example, a cannabinoid or a catechin compound.
    Type: Grant
    Filed: December 17, 2012
    Date of Patent: March 11, 2014
    Assignee: Isis Innovation Limited
    Inventors: Richard Guy Compton, Craig Edward Banks
  • Patent number: 8663452
    Abstract: A method using an electrolytic cell to electrolyze urea to produce at least one of H2 and NH3 is described. An electrolytic cell having a cathode with a first conducting component, an anode with a second conducting component, urea and an alkaline electrolyte composition in electrical communication with the anode and the cathode is used to electrolyze urea. The alkaline electrolyte composition has a hydroxide concentration of at least 0.01 M.
    Type: Grant
    Filed: October 12, 2012
    Date of Patent: March 4, 2014
    Assignee: Ohio University
    Inventor: Gerardine G. Botte
  • Publication number: 20130306492
    Abstract: A method for monitoring a select analyte in a sample in an electrochemical system. The method includes applying to the electrochemical system a time-varying potential superimposed on a DC potential to generate a signal; and discerning from the signal a contribution from the select analyte by resolving an estimation equation based on a Faradaic signal component and a nonfaradaic signal component.
    Type: Application
    Filed: October 18, 2012
    Publication date: November 21, 2013
    Applicant: AGAMATRIX, INC.
    Inventor: AgaMatrix, Inc.
  • Patent number: 8535504
    Abstract: An auxiliary leveler additive that cannot be analyzed by conventional CVS methods for acid copper plating baths is analyzed by cyclic voltammetry at a platinum rotating disk electrode from its effect on the anodic current at very positive potentials.
    Type: Grant
    Filed: April 2, 2011
    Date of Patent: September 17, 2013
    Assignee: ECI Technology, Inc.
    Inventors: Michael Pavlov, Eugene Shalyt, Peter Bratin, Isaak Tsimberg
  • Publication number: 20130220834
    Abstract: A method for detecting at least one property of a gas in a measuring gas chamber, in particular for detecting at least one gas component of the gas. The at least one property is determined using at least one electrochemical measuring cell of a sensor element. Temperatures are detected at at least two different locations of the sensor element and used in determining the at least one property.
    Type: Application
    Filed: July 20, 2011
    Publication date: August 29, 2013
    Inventors: Dirk Liemersdorf, Benjamin Sillmann
  • Patent number: 8512532
    Abstract: The present invention relates to a reaction film formulation used in the preparation of a non-enzymatic whole blood uric acid detecting electrode strip, which comprises an electron mediator, a water-soluble polymer carrier, and a volatile organic solvent, and to whole blood biosensor systems.
    Type: Grant
    Filed: February 21, 2008
    Date of Patent: August 20, 2013
    Assignee: Apex Biotechnology Corporation
    Inventors: Yueh-Hui Lin, Thomas Y. S. Shen
  • Patent number: 8512547
    Abstract: Disclosed in certain embodiments is a method of determining the individual concentration of different antioxidants of the same class in a sample comprising contacting the sample with an effective amount of phenol; and analyzing the sample by voltammetry.
    Type: Grant
    Filed: April 30, 2012
    Date of Patent: August 20, 2013
    Inventor: Robert E. Kauffman
  • Patent number: 8500990
    Abstract: A biosensor for measuring an analyte in a liquid sample includes a working electrode having a dispensed reagent thereon wherein the dispensed reagent contains an enzyme capable of catalyzing a reaction involving the analyte, a mediator that is considered an enzyme inhibitor, and an enzyme co-factor where the working electrode provides a stable and sensitive response even when the biosensor is stored at ambient conditions for a period of time selected from the group consisting of at least 3 months, 12 months and two years or more.
    Type: Grant
    Filed: April 22, 2009
    Date of Patent: August 6, 2013
    Assignee: Nova Biomedical Corporation
    Inventors: Jianhong Pei, Chung Chang Young
  • Publication number: 20130153443
    Abstract: A sensor for measuring a concentration of a specific protein using a biosensor with a measurement speed improved from a conventional impedance measurement. The sensor is capable of efficiently and accurately measuring impedance generated by a selective binding to the protein by Fourier-transforming an electric current signal obtained by applying a potential signal of a delta function waveform. The device for measuring a protein using a biosensor is capable of measuring concentration of the protein with accuracy, measurement time is shortened and the concentration of protein can be accurately measured by removing the influence of dispersion.
    Type: Application
    Filed: January 2, 2013
    Publication date: June 20, 2013
    Applicant: i-SENS
    Inventor: i-SENS
  • Publication number: 20130146480
    Abstract: The invention features the use of graphene, a one atom thick planar sheet of bonded carbon atoms, in the formation of artificial lipid membranes. The invention also features the use of these membranes to detect the properties of polymers (e.g., the sequence of a nucleic acid) and identify transmembrane protein-interacting compounds.
    Type: Application
    Filed: June 8, 2011
    Publication date: June 13, 2013
    Applicant: President and Fellows of Harvard College
    Inventors: Slaven Garaj, Daniel Branton
  • Publication number: 20130126363
    Abstract: The present invention provides a chemiresistor-based sensor for measuring the presence or amount of analyte in an electrolyte solution; said chemiresistor comprising (i) a chemiresistor film wherein the impedance of said nanoparticle film changes in the presence of an analyte; and (ii) two electrically conducting electrodes in electrical contact with said nanoparticle film; wherein said electrically conducting electrodes are adapted to be connected to a device for measuring the impedance of said chemiresistor film under a voltage signal and wherein the impedance of the double layer capacitor formed by the two electrically conducting electrodes in the presence of the electrolyte solution, is larger than the impedance of the chemiresistor film either before or after exposure of the chemiresistor film to the analyte. A method of using said chemiresistor-based sensor to measure the presence or amount of analyte is also provided.
    Type: Application
    Filed: November 8, 2012
    Publication date: May 23, 2013
    Applicant: Commonwealth Scientific and Industrial Research Organisation
    Inventor: Commonwealth Scientific and Industrial Research
  • Patent number: 8419927
    Abstract: In vitro analyte sensors and methods of analyte determination are provided. Embodiments include sensors that include a pair of electrodes to monitor filling of the sample chamber with sample.
    Type: Grant
    Filed: December 6, 2011
    Date of Patent: April 16, 2013
    Assignee: Abbott Diabetes Care Inc.
    Inventors: Yi Wang, Benjamin J. Feldman, Jared L. Watkin
  • Patent number: 8404102
    Abstract: Methods and apparatus for electrochemically determining an analyte concentration value in a physiological sample are disclosed. The methods include using a test strip in which two time-current transients are measured by a meter electrically connected to an electrochemical test strip. Integrative current values are derived from the time-current transients and used in the calculation of analyte concentration.
    Type: Grant
    Filed: July 2, 2010
    Date of Patent: March 26, 2013
    Assignee: Lifescan, Inc.
    Inventors: Sherry Guo, Alastair M. Hodges, Ronald C. Chatelier, Bin Zhang
  • Publication number: 20130068632
    Abstract: A DNA/RNA detection technology is provided. The open flow detection technique includes a substrate defining a pair of opposing microchannels, a pair of opposing electrodes in the opposing microchannels, and at least one ion exchanging nanomembrane coupled between the opposing microchannels such that the opposing microchannels are connected to each other only through the nanomembrane, wherein the nanomembrane is functionalized with a probe complementary to the macromolecule.
    Type: Application
    Filed: May 21, 2012
    Publication date: March 21, 2013
    Applicant: UNIVERSITY OF NOTRE DAME DU LAC
    Inventors: Hsueh-Chia Chang, Zdenek Slouka, Satyajyoti Senapati, Li-Jing Cheng
  • Patent number: 8388827
    Abstract: According to one embodiment of the present invention, an electrochemical sensor (10) for detecting the concentration of analyte in a fluid test sample is disclosed. The sensor (10) includes a counter electrode having a high-resistance portion for use in detecting whether a predetermined amount of sample has been received by the test sensor.
    Type: Grant
    Filed: February 7, 2012
    Date of Patent: March 5, 2013
    Assignee: Bayer HealthCare, LLC
    Inventors: Dijia Huang, Steven C. Charlton, Suny J. George, Andrew J. Edelbrock
  • Publication number: 20130043143
    Abstract: The present invention concerns a device for detecting gases or volatile organic compounds (VOC) comprising an electrically conducting or semiconducting zone f unctionalized with an organic film resulting from the polymerization of aromatic diazonium salt derived monomer.
    Type: Application
    Filed: September 24, 2010
    Publication date: February 21, 2013
    Applicants: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES, CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Guillaume Delapierre, Yanxia Hou-Broutin, Heather McCaig, Edward Myers, Michael L. Roukes
  • Publication number: 20130043140
    Abstract: The present invention is related to a method for detecting at least one chemical analyte vapour in a gaseous environment comprising the steps of: providing a fibre-based electrochemical sensor, said fibre-based sensor comprising at least one type of composite fibres, said type of composite fibres comprising a co-continuous phase blend comprising a first and a second continuous polymer phase, the first polymer phase being sensitive to the chemical analyte vapour to be detected in use, wherein said first polymer phase comprises a dispersion of carbon nanotubes at a concentration above the percolation threshold and wherein the chemical analyte is soluble in said first polymer phase; measuring the initial electrical conductivity of the fibre-based sensor; bringing said fibre-based sensor into contact with at least one chemical analyte to induce a modification of the electrical conductivity of the fibres; measuring the modification of the resulting electrical conductivity of said fibre-based sensor and correla
    Type: Application
    Filed: October 26, 2010
    Publication date: February 21, 2013
    Applicants: UNIVERSITE DE BRETAGNE SUD, NANOCYL S.A.
    Inventors: Frederic Luizi, Luca Mezzo, Jean-François Feller, Mickaël Castro
  • Publication number: 20120267260
    Abstract: An apparatus for examining membrane-bound proteins in a cell can include a chamber with an insulating partition dividing the chamber into an upper well and a lower well, and a pore penetrating the insulating partition. The pore can have a size and shape so as to snugly hold a cell in place therein. The apparatus can further include circuitry for delivering a radio frequency signal to the cell. A belt electrode for delivering electrical signals to the cell can be located within the insulation partition and substantially encircling the pore. A measuring circuit for measuring cell membrane impedance to the radio frequency signal is also provided, and changes in the impedance can signal a change in state of a protein in the cell membrane.
    Type: Application
    Filed: June 7, 2011
    Publication date: October 25, 2012
    Inventors: Sameera Dharia, Richard D. Rabbitt
  • Patent number: 8287717
    Abstract: The present invention relates to systems, methods, and devices for determining the concentration of an analyte in a sample. The use of linear, cyclic, or acyclic voltammetric scans and/or semi-integral, derivative, or semi-derivative data treatment may provide for increased accuracy when determining the concentration of an analyte in a sample. Hematocrit compensation in combination with the data treatments may reduce the hematocrit effect with regard to a glucose analysis in whole blood. In another aspect, fast scan rates may reduce the hematocrit effect.
    Type: Grant
    Filed: May 16, 2005
    Date of Patent: October 16, 2012
    Assignee: Bayer HealthCare LLC
    Inventor: Huan-Ping Wu
  • Publication number: 20120247978
    Abstract: An electrochemical ethylene sensor and method for ethylene sensing are disclosed. In one aspect, an electrochemical ethylene sensor includes a working electrode and a counter electrode on an electrically insulating substrate. An ionic liquid layer covers the working electrode and counter electrode. In one method, a voltage is applied to the working electrode which is equal to or lower than the voltage required for the onset of oxidation of the material of the working electrode, for example, in the range spanning 700 mV before the onset of oxidation of the material of the working electrode.
    Type: Application
    Filed: March 28, 2012
    Publication date: October 4, 2012
    Applicant: Stichting IMEC Nederland
    Inventors: Marcel Zevenbergen, Sywert Brongersma, Mercedes Crego Calama, Daan Wouters
  • Publication number: 20120211375
    Abstract: Use of Morpholinos, a class of uncharged DNA analogues, for surface-hybridization applications. Monolayers of Morpholino probes on gold supports are fabricated with methods similar to those employed with DNA, and are used to hybridize efficiently and sequence-specifically with target strands. Hybridization-induced changes in the interfacial charge organization are analyzed with electrochemical methods and compared for Morpholino and DNA probe monolayers. Molecular mechanisms connecting surface hybridization state to the interfacial capacitance are identified and interpreted through comparison to numerical Poisson-Boltzmann calculations. Positive as well as negative capacitive responses (contrast inversion) to hybridization are possible, depending on surface populations of mobile ions as controlled by the applied potential.
    Type: Application
    Filed: March 18, 2012
    Publication date: August 23, 2012
    Applicant: Polytechnic Institute of New York University
    Inventors: Rastislav Levicky, Napoleon Tercero, Kang Wang, Ping Gong, Kenneth Shepard
  • Publication number: 20120186999
    Abstract: The invention provides an electrochemical sensor comprising an electrode assembly which comprises at least two electrodes, one of the electrodes comprising a metal species capable of catalysing the oxidation of hydrogen and/or methane. The sensor may be used in the detection and quantification of hydrogen and/or methane in exhaled breath, for example as a means of diagnosing lactose malabsorption or lactose intolerance.
    Type: Application
    Filed: April 27, 2010
    Publication date: July 26, 2012
    Applicant: KANICHI RESEARCH SERVICES LIMITED
    Inventors: David John Walton, Xiaobo Ji, Craig Edward Banks
  • Patent number: 8216447
    Abstract: The invention disclosed is a total organic carbon (TOC) analyzer comprised of an electrochemical cell comprising a diamond-film electrode doped with boron or other conductivity inducing material. The diamond-film electrode is the working electrode and carries out the oxidation of TOC to produce carbon dioxide. The apparatus further comprises sensors for detecting the carbon dioxide produced. Such sensors include but are not limited to a tunable diode laser and/or ion-selective electrode. The invention also discloses a method for measuring TOC in an aqueous solution using a total organic carbon analyzer.
    Type: Grant
    Filed: December 14, 2009
    Date of Patent: July 10, 2012
    Assignee: O.I. Corporation
    Inventor: Samuel P. Kounaves
  • Patent number: 8187455
    Abstract: Disclosed in certain embodiments is a method of determining the individual concentration of different antioxidants of the same class in a sample comprising contacting the sample with an effective amount of phenol; and analyzing the sample by voltammetry.
    Type: Grant
    Filed: July 18, 2008
    Date of Patent: May 29, 2012
    Assignee: Socomer NV.
    Inventor: Robert E. Kauffman
  • Patent number: 8152991
    Abstract: Embodiments of nanoelectronic sensors are described, including sensors for detecting analytes such ammonia. An environmental control system employing nanoelectronic sensors is described. A personnel safety system configured as a disposable badge employing nanoelectronic sensors is described. A method of dynamic sampling and exposure of a sensor providing a number of operational advantages is described.
    Type: Grant
    Filed: December 8, 2006
    Date of Patent: April 10, 2012
    Assignee: Nanomix, Inc.
    Inventors: Mikhail Briman, Craig Bryant, Ying-Lan Chang, Jean-Christophe P. Gabriel, Shirpal C. Gandhi, Bradley N Johnson, Willem-Jan Ouborg, John Loren Passmore, Kastooriranganathan Ramakrishnan, Sergei Skarupo, Alexander Star, Christian Valcke