Of Biological Material (e.g., Urine, Etc.) Patents (Class 205/792)
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Patent number: 8480869Abstract: The present invention provides a method of electrochemically measuring a hematocrit (Hct) value using a sensor, capable of achieving excellent measurement accuracy and reliability and also provides a sensor used in the method. The method of electrochemically measuring a hematocrit (Hct) value of blood include: providing an electrode system having a working electrode (11) and a counter electrode (12), in which a redox substance is provided on the counter electrode (12) but not on the working electrode (11); supplying blood to the electrode system; applying a voltage to the electrode system in this state to cause an oxidation current or a reduction current to flow between the working electrode (11) and the counter electrode (12); detecting the oxidation current or the reduction current; and determining a Hct value based on a value of the detected current.Type: GrantFiled: October 24, 2011Date of Patent: July 9, 2013Assignee: Panasonic CorporationInventors: Masaki Fujiwara, Teppei Shinno, Shin Ikeda
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Patent number: 8480868Abstract: A method for distinguishing between types of electrochemical test sensors in a meter is disclosed. The method comprises the acts of providing an electrochemical test sensor comprising an enzyme and a chemical additive, contacting the test sensor to the meter to form an electrical connection, applying a potential having a magnitude sufficient to initiate a redox reaction of the chemical additive, and determining which type of electrochemical test sensor is being used based on whether a predetermined signal has been generated after the potential has been applied. The meter is adapted to determine an analyte concentration in a fluid sample.Type: GrantFiled: May 24, 2012Date of Patent: July 9, 2013Assignee: Bayer HealthCare LLCInventor: Daniel V. Brown
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Patent number: 8475646Abstract: Methods are disclosed for measuring substrate content in a specimen using a biosensor that includes two pairs of electrodes in a specimen supply path, where the methods include the steps of: (a) a first detecting step for detecting an electrical change in the first pair of electrodes; (b) a second detecting step for detecting an electrical change in the second pair of electrodes after the first detecting step; (c) a judging step for judging a shortage of specimen amount that is needed for measurement, when an electrical change is not detected in the second detecting step within a prescribed period of time after the first detecting step; (d) an indicating step for indicating a shortage of the specimen amount; and (e) a stopping step for stopping measurement of substrate content in the specimen once the shortage of specimen amount is indicated in the indicating step.Type: GrantFiled: July 15, 2011Date of Patent: July 2, 2013Assignee: Panasonic CorporationInventors: Shoji Miyazaki, Masaki Fujiwara, Yoshinobu Tokuno
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Publication number: 20130161206Abstract: According to one embodiment of the present invention, an electrochemical sensor (10) for detecting the concentration of analyte in a fluid test sample is disclosed. The sensor (10) includes a counter electrode having a high-resistance portion for use in detecting whether a predetermined amount of sample has been received by the test sensor.Type: ApplicationFiled: February 25, 2013Publication date: June 27, 2013Applicant: Bayer HealthCare LLCInventor: Bayer HealthCare LLC
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Patent number: 8470162Abstract: Quantifying devices and methods are disclosed for quantifying substrate content using a biosensor where the methods include a first detecting step for detecting an electrical change generated between a measuring electrode and a counter electrode of a biosensor by applying a sample liquid to the biosensor; a second detecting step for detecting an electrical change generated between a detecting electrode of the biosensor and the counter electrode or the measuring electrode by applying the sample liquid to the biosensor; and a notification step for informing a user when the second detecting step does not occur within a predetermined period after the first detecting step.Type: GrantFiled: January 20, 2011Date of Patent: June 25, 2013Assignee: Panasonic CorporationInventors: Shoji Miyazaki, Masaki Fujiwara, Yoshinobu Tokuno
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Publication number: 20130146479Abstract: An apparatus is disclosed comprising: a sample conduit; an electrochemical flow cell; a source of carrier fluid; a structure elucidation spectrometer; a conduit and an in-line sample reservoir, such that: (a) a first operating modus wherein the sample conduit is connected to the conduit via the electrochemical flow cell and the in-line sample reservoir, and the source of carrier fluid is connected to the by-passing the in-line sample reservoir, and (b) a second operating modus wherein the sample conduit is connected to the conduit by-passing the in-line sample reservoir, and the source of carrier fluid is connected to the structure elucidation spectrometer via the in-line sample reservoir. Decoupling of the electrochemical cell from the spectrometer allows for uncompromised selection of optimal electrochemical and separation conditions.Type: ApplicationFiled: May 21, 2010Publication date: June 13, 2013Applicant: ANTEC LEYDEN B.V.Inventors: Hendrik-Jan Brouwer, Agnieszka Urszula Kraj, Jean-Pierre Chervet
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Patent number: 8460539Abstract: A method of determining concentrations of a plurality of analytes from a single blood sample placed in a single opening. A portion of the single blood sample is absorbed by a test matrix that includes a plurality of layers and a chromogenic agent. A colored response is generated by the test matrix. The colored response is proportional to the concentration of a first analyte. A portion of the single blood sample is drawn into a capillary tube and placed in contact with an electrode and a counter-electrode. An electrical property of the single blood sample is analyzed through the electrode and counter-electrode. The electrical property is proportional to the concentration of a second analyte in the single blood sample.Type: GrantFiled: June 11, 2009Date of Patent: June 11, 2013Assignee: Polymer Technology Systems, Inc.Inventors: Robert Huffstodt, James J. Sutor
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Patent number: 8460524Abstract: Methods and systems for measuring the concentration of an analyte in a blood sample and, more particularly, to methods of chemistry patterning reagent layers for multiple well biosensors. A first capillary is first configured to receive a dispensed reagent layer such that the reagent layer is distributed in a substantially uniform manner within the first capillary. The first capillary may also configured to isolate the first capillary from other capillaries present in the biosensor. After the reagent layer has been dispensed and dried, the first capillary may then be reconfigured to allow the first capillary to receive a blood sample.Type: GrantFiled: April 14, 2008Date of Patent: June 11, 2013Assignee: Nipro Diagnostics, Inc.Inventors: Natasha Popovich, Gary T. Neel, William Milo, Zachary Thomas, Stephen Davies
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Patent number: 8460537Abstract: A method for determining an analyte concentration in blood is described that reduces the effects of hematocrit using a test strip attached to a test meter. The test strip includes a working electrode and a reference electrode. The test meter applies a test voltage between the working electrode and the reference electrode. After a user applies a blood sample containing an analyte onto the test strip, the test meter measures a plurality of test currents for a test time interval.Type: GrantFiled: September 3, 2009Date of Patent: June 11, 2013Assignee: LifeScan Scotland LimitedInventors: Stephen Patrick Blythe, Marco F Cardosi, Leanne Mills, Manuel Alvarez-Icaza, Emma Vanessa Jayne Day, Richard Michael Day, Christopher Philip Leach
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Patent number: 8460531Abstract: An integrated bio-analysis system incorporates built-in sample preparation capabilities. In one aspect of the present invention, a bio-analysis instrument is provided with a built-in sample preparation device based on PCR (or thermal cycling block/module). In one embodiment of the present invention, a peltier unit in the sample preparation device provides thermal cycling of samples supported in a multi-well tray. In another aspect of the present invention, a CE instrument is provided with a built-in sample preparation capability, which may comprise a sample preparation (bio-molecular reaction) device based on thermal cycler type. In another aspect of the present invention, a PCR device is provided with a built-in analysis device, such as a CE device, for verifying the results of the PCR (bio-molecular reaction) process.Type: GrantFiled: December 6, 2010Date of Patent: June 11, 2013Assignee: Qiagen Sciences, LLCInventors: Varouj Amirkhanian, Ming-Sun Liu
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Publication number: 20130143246Abstract: A hand-held test meter for use with an analytical test strip in the determination of an analyte in a bodily fluid sample (e.g., a whole blood sample) includes a housing, with an outer surface, and an analytical test strip ejection mechanism (“ATSEM”). The ATSEM has an actuation button disposed in the outer surface of the housing, a motion amplification and rotation assembly (“MA&RA”) operatively connected to the actuation button and a test strip slider (“TSS”) operatively connected to the MA&RA. The actuation button is configured for movement by a user's digit in a first direction and the MA&RA and TSS are configured to convert the movement in the first direction into amplified movement of the TSS in a second direction with the second direction being rotated with respect to the first direction. Moving the TSS in the second direction from the engaged state to an ejected state ejects the strip.Type: ApplicationFiled: December 2, 2011Publication date: June 6, 2013Applicant: LifeScan Scotland Ltd.Inventors: Jonny NELSON, Alan Faulkner, Luca Valsecchi, Roberto Beretta, Maurizio Volpe, Michele Sala, Nick Foley, Colin Crossland, Paul Trickett
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Publication number: 20130144131Abstract: Techniques and systems are disclosed for implementing textile-based screen-printed amperometric or potentiometric sensors. The chemical sensor can include carbon based electrodes to detect at least one of NADH, hydrogen peroxide, potassium ferrocyanide, TNT or DNT, in liquid or vapor phase. In one application, underwater presence of chemicals such as heavy metals and explosives is detected using the textile-based sensors.Type: ApplicationFiled: May 18, 2011Publication date: June 6, 2013Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Joseph Wang, Joshua Ray Windmiller
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Publication number: 20130140192Abstract: The present invention relates to a method of producing a lipid bilayer over a microcavity open on one side and to a microstructure for investigating lipid bilayers and an associated measuring arrangement. The method of producing a lipid bilayer over a microcavity open on one side comprises the following steps: filling the microcavity with an electrolyte solution; moving a fluid containing dissolved lipids in a first direction onto the microcavity; moving the fluid in a second direction away from the microcavity; monitoring the formation of the lipid bilayer over the microcavity by detecting an impedance between a counter-electrode connected to the fluid and a measuring electrode, which is arranged inside the microcavity.Type: ApplicationFiled: June 1, 2011Publication date: June 6, 2013Applicant: ALBERT-LUDWIGS-UNIVERSITÄT FREIBURGInventors: Jan Behrends, Gerhard Baaken
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Patent number: 8454820Abstract: Constitute a molecular recognition probe comprising: an electrochemically active group; an activity suppression group that suppresses an electrochemical activity of the electrochemically active group; a receptor area where a molecule of a target substance is specifically recognized; and a molecule area where a steric structure is changed as a result of molecular recognition; wherein the electrochemically active group is suppressed of its activity by the activity suppression group before the molecule is recognized and restores its activity after the molecule is recognized; or constitute a molecular recognition sensor by providing an anchor area on the molecular recognition probe and fixing it on a surface of an electrode.Type: GrantFiled: August 31, 2010Date of Patent: June 4, 2013Assignee: National Institute of Advanced Industrial Science and TechnologyInventors: Hiroshi Aoki, Hiroaki Tao, Akiko Kitajima
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Patent number: 8449740Abstract: Described herein are systems and methods for distinguishing between a control solution and a blood sample. In one aspect, the methods include using a test strip in which multiple current transients are measured by a meter electrically connected to an electrochemical test strip. The current transients are used to determine if a sample is a blood sample or a control solution based on at least two characteristics. Further described herein are methods for calculating a discrimination criteria based upon at least two characteristics. Still further described herein are system for distinguishing between blood samples and control solutions.Type: GrantFiled: July 21, 2010Date of Patent: May 28, 2013Assignee: LifeScan, Inc.Inventors: Ronald C. Chatelier, Alastair M. Hodges, Maria Teodorczyk, Remedios Dato
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Patent number: 8449758Abstract: A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry; and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent.Type: GrantFiled: September 29, 2009Date of Patent: May 28, 2013Assignee: Abbott Diabetes Care Inc.Inventors: Benjamin J. Feldman, Adam Heller, Ephraim Heller, Fei Mao, Joseph A. Vivolo, Jeffery V. Funderburk, Fredric C. Colman, Rajesh Krishnan
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Publication number: 20130118921Abstract: The presence of oxygen or red blood cells in a sample applied to an electrochemical test strip that makes use of a reduced mediator is corrected for by an additive correction factor that is determined as a function of the temperature of the sample and a measurement that reflects the oxygen carrying capacity of the sample. The measured oxygen carrying capacity can also be used to determine hematocrit and to distinguish between blood samples and control solutions applied to a test strip.Type: ApplicationFiled: December 21, 2012Publication date: May 16, 2013Applicant: AGAMATRIX, INC.Inventor: AGAMATRIX, INC.
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Publication number: 20130115632Abstract: A highly sensitive method of assaying an analyte present in a sample using protamine is provided, as well as an immunoassay reagent and biosensor that reduces non-specific binding by electrostatic interaction of protamine with fibrinogen present in the sample.Type: ApplicationFiled: April 24, 2012Publication date: May 9, 2013Applicant: SAMSUNG ELECTRONICS CO., LTD.Inventors: Joon Hyung LEE, Soo Suk LEE, Youn Suk CHOI, Jin Young PARK, Hye Jung SEO, Jung Nam LEE, Kyung Yeon HAN
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Patent number: 8435393Abstract: An instrument is provided for pharmacologic measurement capable of detecting a very small and short time change in electric signal caused by a pharmacologic action of a biologic specimen with quickness and a high sensitivity by steeply decreasing an external disturbance component mixed into the system while dropping/exchange of medicinal solutions is conducted in a batch mode.Type: GrantFiled: January 22, 2010Date of Patent: May 7, 2013Assignee: Panasonic CorporationInventors: Nobuhiko Ozaki, Hiroaki Oka
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Publication number: 20130105334Abstract: A sample measurement device (110), in which a biosensor (30) having an electrode is mounted, voltage is applied to the electrode, and the concentration of a specific component in a sample deposited on the biosensor (30) is measured, comprises a voltage source (19) configured to apply voltage to the electrode, a time measurement component (22), and a controller (18) configured to control the voltage to be applied and measure the concentration of the specific component. The time measurement component (22) measures a detection time, which is the length of time between the mounting of the biosensor (30) and the deposition of a sample on the biosensor (30). The controller (18) changes a set value for measuring the concentration of a specific component according to the detection time. Consequently, measurement accuracy can be improved regardless of the temperature of the biosensor (30).Type: ApplicationFiled: December 17, 2012Publication date: May 2, 2013Applicant: PANASONIC CORPORATIONInventor: PANASONIC CORPORATION
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Patent number: 8431011Abstract: The present invention is directed to electrochemical sensors and systems and methods for electrochemically sensing a particular constituent within a fluid through the use of a diagnostic test. The methods provide for automatic discrimination of sample from control or standard solutions. A device and system used to determine a constituent level within a fluid that employ such automatic sample discrimination methods or specially formulated solutions is also provided.Type: GrantFiled: January 31, 2008Date of Patent: April 30, 2013Assignee: Abbott Diabetes Care Inc.Inventors: Yi Wang, Benjamin J. Feldman
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Publication number: 20130098780Abstract: A sensor system comprising a substrate and integrated onto the substrate an array (7) of sensor elements (1), each sensor element comprising one or more inductors (3), one or more electrochemical sensors (4), and one or more optical sensors (2). The system further comprising a controller configured in use to separately address each of the sensor elements (1) to drive the respective inductors and receive outputs of the respective sensors.Type: ApplicationFiled: January 28, 2011Publication date: April 25, 2013Applicant: DNA Electronics LimitedInventors: Pantelis Georgiou, Themistoklis Prodromakis, Timothy G. Constandinou, Christofer Toumazou
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Publication number: 20130101905Abstract: A porous electrochemical electrode is made up of a solid cellular material provided in the form of a semi-graphitised carbon monolith comprising a hierarchised porous network free of mesopores and including macropores with a mean dimension dA of 1 ?m to 100 ?m, and micropores with a mean dimension dI of 0.5 nm to 2 nm, said macropores and micropores being interconnected. In said electrode, the macropores contain at least one electroactive species in direct contact with the semi-graphitised carbon that makes up the surface of the macropores. The invention also relates to a method for preparing such an electrode as well as to the use thereof as a biosensor or for manufacturing a biopile.Type: ApplicationFiled: January 19, 2011Publication date: April 25, 2013Inventors: Nicolas Mano, Victoria Flexer, Nicolas Brun, Rénal Backov
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Publication number: 20130098776Abstract: A method for estimation of hematocrit of a sample having an analyte includes: bringing the sample into contact with a sensor strip including a reference electrode coated with a reference layer nonreactive to the analyte, and a working electrode coated with a working layer including a biorecognition element reactive to the analyte; applying a voltage between the reference and working electrodes, and recording information of a reaction current flowing through the sample within a time period of not greater than 5 seconds from beginning of application of the voltage; and estimating the hematocrit of the sample by analyzing the recorded information using a predetermined current-hematocrit function.Type: ApplicationFiled: September 14, 2012Publication date: April 25, 2013Applicant: Bionime CorporationInventor: Cheng-Teng Hsu
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Patent number: 8427298Abstract: Methods and apparatus for providing multi-stage signal amplification in a medical telemetry system are provided.Type: GrantFiled: April 2, 2012Date of Patent: April 23, 2013Assignee: Abbott Diabetes Care Inc.Inventor: Martin J. Fennell
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Patent number: 8425758Abstract: A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry, and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent.Type: GrantFiled: September 29, 2009Date of Patent: April 23, 2013Assignee: Abbott Diabetes Care Inc.Inventors: Benjamin J. Feldman, Adam Heller, Ephraim Heller, Fei Mao, Joseph A. Vivolo, Jeffery V. Funderburk, Fredric C. Colman, Rajesh Krishnan
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Patent number: 8425757Abstract: A sensor system, device, and methods for determining the concentration of an analyte in a sample is described. Gated amperometric pulse sequences including multiple duty cycles of sequential excitations and relaxations may provide a shorter analysis time and/or improve the accuracy and/or precision of the analysis. The disclosed gated amperometric pulse sequences may reduce analysis errors arising from the hematocrit effect, variance in cap-gap volumes, non-steady-state conditions, mediator background, under-fill, temperature changes in the sample, and a single set of calibration constants.Type: GrantFiled: December 19, 2007Date of Patent: April 23, 2013Assignee: Bayer HealthCare LLCInventors: Huan-Ping Wu, Christine D. Nelson, Greg P. Beer
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Patent number: 8425759Abstract: Analytes in a liquid sample are determined by methods utilizing sample volumes of up to 1.0 ?l and test times from about 4 to about 9 seconds after detection of the sample. The methods are preferably performed using small test strips including a sample receiving chamber filled with the sample by capillary action.Type: GrantFiled: January 11, 2012Date of Patent: April 23, 2013Assignee: Roche Diagnostics Operations, Inc.Inventor: Christopher D. Wilsey
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Patent number: 8419927Abstract: In vitro analyte sensors and methods of analyte determination are provided. Embodiments include sensors that include a pair of electrodes to monitor filling of the sample chamber with sample.Type: GrantFiled: December 6, 2011Date of Patent: April 16, 2013Assignee: Abbott Diabetes Care Inc.Inventors: Yi Wang, Benjamin J. Feldman, Jared L. Watkin
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Publication number: 20130087467Abstract: Apparatus and methods are provided for improving sensitivity, throughput, and efficiency of multi-analyte analytical testing. Specifically, an improved Electrochemiluminescence (ECL) analytical apparatus is provided for analytical chemistry, diagnostics, and environmental applications. The ECL apparatus comprises a 96 or more-well plate, where a microarray of working electrodes is placed in each well for high throughput and multi-analyte testing. The microarray of working electrodes connects with a counter electrode forming a two-electrode electrochemical system. Each well is electrically addressable, thereby controlling ECL reactions in flexible modes. The ECL apparatus further comprises a detector of ECL signals, and the detector employs a CCD-chip assembling matrix. Also provided are methods for high-throughput multi-analyte testing.Type: ApplicationFiled: June 25, 2012Publication date: April 11, 2013Inventor: Hongjun Yang
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Publication number: 20130087468Abstract: Mastitis in a milking animal is detected through sensing the capacitance effects in milk. Using frequencies of greater than 60 megahertz applied by a capacitance probe to milk as it streams through otherwise conventional milking equipment during milking, yields a reliably discernable shift in the phase angle, indicating the presence of mastitis.Type: ApplicationFiled: October 8, 2012Publication date: April 11, 2013Inventor: Michael Hoey
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Patent number: 8414762Abstract: Devices and methods for determining the concentration of an analyte in a sample of liquid are provided.Type: GrantFiled: June 5, 2012Date of Patent: April 9, 2013Assignee: Abbott Diabetes Care Inc.Inventors: Adrian Petyt, Simon Andrew Hector
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Patent number: 8414760Abstract: The present invention is based on the discovery of NAD+ and NADP+ mediator compounds that do not bind irreversibly to thiol groups in the active sites of intracellular dehydrogenase enzymes. Such mediator compounds avoid a common mode of enzyme inhibition. The mediators can therefore increase the stability and reliability of the electrical response in amperometric electrodes constructed from NAD- or NADP-dependent enzymes.Type: GrantFiled: July 30, 2012Date of Patent: April 9, 2013Assignee: Abbott LaboratoriesInventors: Nigel J. Forrow, Gurdial S. Sanghera, Jared L. Watkin, Stephen Walters
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Patent number: 8414761Abstract: A biosensor comprises a space part for sucking and housing a sample formed of two upper and lower plates, the two plates being stuck together by an adhesive layer, the space part for sucking and housing the sample being constituted so as to be partially opened in the peripheral part and partially closed by the adhesive layer, and has a working electrode having at least glucose oxidase immobilized thereon and a counter electrode on the same plane of the plate.Type: GrantFiled: September 6, 2011Date of Patent: April 9, 2013Assignee: Abbott Diabetes Care Inc.Inventors: Masao Gotoh, Hiroki Mure, Hiroshi Shirakawa
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Publication number: 20130081959Abstract: In vitro electrochemical sensor that provide accurate and repeatable analysis of a sample of biological fluid are provided. In some embodiments, the sensors have a measurement zone that has a volume less than the volume of the sample chamber. The measurement zone could have a volume of no more than about 0.2 ?L.Type: ApplicationFiled: September 27, 2012Publication date: April 4, 2013Applicant: ABBOTT DIABETES CARE INC.Inventor: ABBOTT DIABETES CARE INC.
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Patent number: 8409424Abstract: An electrochemical test strip, an electrochemical test system, and a measurement method using the same are provided. The electrochemical test strip includes an insulating substrate, an electrode system formed on the insulating substrate, and an insulating layer formed on the electrode system. The electrode system includes a set of measurement electrodes, a set of identifying electrodes, and a resistive path having a predetermined resistance value. The set of identifying electrodes is made of metal material, and the resistive path is made of non-metal material. The set of measurement electrodes includes a reference electrode and a working electrode insulated from each other, and the set of identifying electrodes includes a first identifying electrode and a second identifying electrode connected with each other through the resistive path.Type: GrantFiled: December 18, 2009Date of Patent: April 2, 2013Assignee: Apex Biotechnology Corp.Inventors: Guan-Ting Chen, Yueh-Hui Lin, Kai-Tsung Teng, Sz-Hau Chen, Thomas Y. S. Shen
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Patent number: 8409425Abstract: The disclosure provides for reagent compositions for biosensors comprising release polymers, methods of making such biosensors and films of reagent compositions comprising release polymers. The reagent compositions comprise a release polymer and an effective analyte detecting amount of an enzyme an enzyme cofactor and a redox compound capable of acting in a biosensor as (i) a redox mediator associated with a working electrode (ii) a redox couple associated with a reference electrode or (iii) the redox mediator associated with the working electrode and the redox couple for the reference electrode.Type: GrantFiled: August 7, 2012Date of Patent: April 2, 2013Assignee: Abbott Diabetes Care Inc.Inventors: Nigel John Forrow, Shridhara Alva Karinka
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Publication number: 20130075279Abstract: The present invention relates to the field of surface water monitoring. More specifically, the present invention provides low-cost, real-time bio-electrochemical sensors for surface water monitoring based on the metabolism of one or more electrogenic microbes.Type: ApplicationFiled: December 8, 2010Publication date: March 28, 2013Applicant: CAMBRIAN INNOVATION, INC.Inventors: Justin Buck, Matthew Silver
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Patent number: 8404100Abstract: A sensor system, device, and methods for determining the concentration of an analyte in a sample is described. Gated voltammetric pulse sequences including multiple duty cycles of sequential excitations and relaxations may provide a shorter analysis time and/or improve the accuracy and/or precision of the analysis. The disclosed pulse sequences may reduce analysis errors arising from the hematocrit effect, variance in cap-gap volumes, non-steady-state conditions, mediator background, a single set of calibration constants, under-fill, and changes in the active ionizing agent content of the sensor strip.Type: GrantFiled: February 26, 2008Date of Patent: March 26, 2013Assignee: Bayer HealthCare LLCInventor: Huan-Ping Wu
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Patent number: 8404096Abstract: The invention relates to methods of preparation of highly sensitive potentiometric sensors with an electroconductive polymer film as a sensing element.Type: GrantFiled: August 23, 2002Date of Patent: March 26, 2013Assignee: Sensortec LimitedInventors: Duncan Ross Purvis, Olga Leonardova, Dmitri Alexandrovich Farmakovski, Vladimir Rurikovich Tcherkassov
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Patent number: 8404102Abstract: Methods and apparatus for electrochemically determining an analyte concentration value in a physiological sample are disclosed. The methods include using a test strip in which two time-current transients are measured by a meter electrically connected to an electrochemical test strip. Integrative current values are derived from the time-current transients and used in the calculation of analyte concentration.Type: GrantFiled: July 2, 2010Date of Patent: March 26, 2013Assignee: Lifescan, Inc.Inventors: Sherry Guo, Alastair M. Hodges, Ronald C. Chatelier, Bin Zhang
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Publication number: 20130068632Abstract: A DNA/RNA detection technology is provided. The open flow detection technique includes a substrate defining a pair of opposing microchannels, a pair of opposing electrodes in the opposing microchannels, and at least one ion exchanging nanomembrane coupled between the opposing microchannels such that the opposing microchannels are connected to each other only through the nanomembrane, wherein the nanomembrane is functionalized with a probe complementary to the macromolecule.Type: ApplicationFiled: May 21, 2012Publication date: March 21, 2013Applicant: UNIVERSITY OF NOTRE DAME DU LACInventors: Hsueh-Chia Chang, Zdenek Slouka, Satyajyoti Senapati, Li-Jing Cheng
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Patent number: 8399259Abstract: The measuring device of the invention includes: a first container and a second container for holding a sample; and an optical measurement part for carrying out an optical measurement. The first container has a first sample supply inlet for supplying a sample containing an analyte to the first container and at least one electrode. The second container has a second sample supply inlet for supplying the sample to the second container and a reagent holding part for holding a reagent for the optical measurement.Type: GrantFiled: April 28, 2010Date of Patent: March 19, 2013Assignee: Panasonic CorporationInventors: Atsushi Fukunaga, Takahiro Nakaminami, Akihito Kamei
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Patent number: 8398845Abstract: A measuring device for analyzing a sample liquid having at least one analyte is provided. A test field support housed in the device includes a number of individual test fields in communication with electrochemical measuring cells of the test field support. Reagents can be assigned to the electrochemical measuring cells which can react with a sample liquid. The reaction can lead to a measurable change of at least one quantity characteristic of the presence or concentration of an analyte in the sample. The measuring device includes evaluation electronics. The individual test fields on the test field support are accessible to the user after the measuring device has been opened.Type: GrantFiled: October 15, 2007Date of Patent: March 19, 2013Assignee: Roche Diagnostics Operations, Inc.Inventors: Michael Marquant, Mihail-Onoriu Lungu
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Publication number: 20130056367Abstract: The present invention is generally directed to devices and methods for sensing a variety of biologically-related substances and/or chemical substances. In a device aspect, the present invention is directed to a multilayer device for sensing metal ions, non-biological molecules, biological molecules, or whole cells. In a method aspect, the present invention is directed to a method for sensing species such as ions, protons, metal ions, non-biological molecules, whole cells, and biological molecules, for example one or more biologically-related substances such as proteins, nucleic acids, DNA, RNA, enzymes, and chemical substances such as water contaminants.Type: ApplicationFiled: September 4, 2012Publication date: March 7, 2013Inventors: William E. Martinez, Matthew R. Leyden
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Patent number: 8388827Abstract: According to one embodiment of the present invention, an electrochemical sensor (10) for detecting the concentration of analyte in a fluid test sample is disclosed. The sensor (10) includes a counter electrode having a high-resistance portion for use in detecting whether a predetermined amount of sample has been received by the test sensor.Type: GrantFiled: February 7, 2012Date of Patent: March 5, 2013Assignee: Bayer HealthCare, LLCInventors: Dijia Huang, Steven C. Charlton, Suny J. George, Andrew J. Edelbrock
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Publication number: 20130048512Abstract: The present disclosure relates to various methods for measuring the amount of an analyte present in a biological fluid using an electrochemical testing process. Various embodiments are disclosed, including the use of AC test signals and the performance of tests having a Total Test Time within about 3.0 seconds or less, and/or having a clinically low Total System Error.Type: ApplicationFiled: October 24, 2012Publication date: February 28, 2013Inventors: Eric R. Diebold, Terry A. Beaty, Harvey B. Buck, JR.
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Publication number: 20130043142Abstract: Methods and systems for measuring the oxidation-reduction potential of a fluid sample are provided. The system includes a test strip with a sample chamber adapted to receive a fluid sample. The sample chamber can be associated with a filter membrane. The test strip also includes a reference cell. The oxidation-reduction potential of a fluid sample placed in the sample chamber can be read by a readout device interconnected to a test lead that is in electrical contact with the sample chamber, and a reference lead that is in electrical contact with the reference cell. Electrical contact between a fluid sample placed in the sample chamber and the reference cell can be established by a bridge. The oxidation-reduction potential may be read as an electrical potential between the test lead and the reference lead of the test strip.Type: ApplicationFiled: October 24, 2012Publication date: February 21, 2013Applicant: INSTITUTE FOR MOLECULAR MEDICINE, INC.Inventor: INSTITUTE FOR MOLECULAR MEDICINE, INC.
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Publication number: 20130043141Abstract: The present disclosure relates to various methods for measuring the amount of an analyte present in a biological fluid using an electrochemical testing process. Various embodiments are disclosed, including the use of AC test signals and the performance of tests having a Total Test Time within about 3.0 seconds or less, and/or having a clinically low Total System Error.Type: ApplicationFiled: October 24, 2012Publication date: February 21, 2013Applicant: Roche Diagnostics Operations, Inc.Inventor: Roche Diagnostics Operations, Inc.
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Publication number: 20130045416Abstract: Synthesis of gold microtubes and nanotubes suspendable in solution is presented. The synthesis is accomplished using an AAO template route, wherein a polymer tube is used as a sacrificial core. The synthesis produces hollow structures that consist of only gold. These nanostructures exhibit two SPR modes, which correspond to both the transverse and longitudinal modes. The mode assignment was confirmed by measuring SPR behavior as both aligned arrays and in solution. The performance of gold nanotubes as refractive index detectors was quantified and determined to be more sensitive than analogous solid nanorods prepared under identical conditions, and are among the most sensitive nanostructured plasmon sensors to date. Due to their intense and sensitive resonances in the NIR spectrum, these solution-suspendable nanoparticles have potential to be used as in vitro or in vivo sensors.Type: ApplicationFiled: August 15, 2012Publication date: February 21, 2013Inventors: Dwight S. SEFEROS, Colin BRIDGES, Paul DICARMINE