Abstract: A balancing unit for medical fluids includes at least one balancing chamber and at least one conveying unit for filling the balancing chamber, in which the conveying unit is a pressure controlled conveying unit and/or is designed and provided for being operated in at least one operating state as a constant-pressure source. An external medical functional unit, a treatment apparatus and methods are also described.

Abstract: A process for purification of fluids, for example, desalination of seawater or brackish water, using organic solutes in a concentrated water solution for use in a forward osmosis process, to extract fresh water out of salt water through the forward osmosis membrane, and subsequently separating the organic solutes out of the diluted forward osmosis permeate by cloud point extraction, thereby regenerating a concentrated organic solution for recycling to the forward osmosis process, and fresh water for potable water use.

Abstract: The present invention is directed to an alternative compact portable filtration device that can be used in remote locations and includes a single filtration cartridge that provides redundant filtration of the fluid (water). In particular, the device is a dual stage ultrafilter cartridge (apparatus) that is constructed and designed to provide a portable device that can be used in the field, such as during camping or military assignment, and offers two filtration stages (redundant filtration) within a single housing.

Abstract: A dialysis system instrument includes a dialysis instrument, a disposable pumping and valving cassette apparatus operable with pumping and valving actuators of the dialysis instrument, the disposable cassette including an electronic cell and electronics associated with the electronic cell, the electronics configured to determine an electrical property of a solution flowing through the electronic cell of the disposable apparatus.

Abstract: The present invention relates to a safety insert or transducer protector 10, suitable for an extra-corporeal circuit 8. The transducer protector 10 comprises a first shell 11 comprising a first hydrophobic semi-permeable membrane 13 and a first tubular connector 15 adapted to be connected to a branch pipe 17 from the extra-corporeal circuit 8; a second shell 12, at least partially translucent, comprising a second hydrophobic semi-permeable membrane 14 and a second tubular connector 16 adapted to be connected to a transducer 18. The transversal area of said second shell 12 is larger than the transversal area of said first shell 11.

Abstract: Composite membranes, methods or processes for producing composite membranes, and systems utilizing composite membranes are generally described. In some examples, a composite membrane includes a porous halogenated polymer and a conductive polymer coupled to the porous halogenated polymer. In some examples, a process for producing a composite membrane includes coupling a conductive polymer and a porous halogenated polymer.

Abstract: According to one exemplary embodiment, a compact fluid purification device includes a housing having an inlet for receiving unfiltered liquid and an open end and a first valve disposed within the inlet and being configured to only permit unfiltered liquid to flow into a hollow interior of the housing. The device has a plunger received within the open end such that it slides within the interior of the housing. The plunger is movable between a fully extended position and a fully retracted position, wherein the plunger has an elongated housing that includes a filter element, such as, a plurality of hollow filter elements that are open at a distal end of the plunger housing and are in communication with an outlet that is associated with the plunger.

Abstract: A dialysis system includes: a dialysis machine for performing a first dialysis session on a patient at a first time of a day; a remote exchange device for performing a second dialysis session on the patient at a second time of the day, the remote exchange device configured to record an amount of ultrafiltration (“UF”) that is removed from the patient over the second dialysis session; and a communication link between the dialysis machine and the remote exchange device, wherein the dialysis machine is configured to receive the recorded amount UF removed from the remote exchange device via the communication link and determine a total amount of UF removed from the patient over the first and second sessions.

Abstract: A separating membrane for use particularly in pressure sensors, for separating between a process fluid and a pressure-transferring hydraulic oil, is described. The separating membrane is in the form of a thin foil covering an opening into a volume containing the oil, with the foil being fastened to the edges of the opening, and is characterized in that the separating membrane is fastened at the edges of the opening in such a manner that it, in at least one region of its area, exhibits a transition from a concave to convex bulging, whereby the membrane is able to accommodate a volume change of the oil through a non-energy requiring translation of the transition(s). Also described are a method of manufacturing the separating membrane as well as a pressure sensor comprising the separating membrane.

Abstract: A dialysis system including a housing, a dialysate pump disposed in the housing, and a dialysate line configured to be operatively connected to the dialysate pump such that the dialysate pump can pump dialysate through the dialysate line when the dialysate line is in fluid communication with a dialysate source.

Abstract: Artificial kidney for gradual, and at least semi-continuous, blood treatment, wherein a blood stream is fed from a body of a living human or animal being into the artificial kidney, where anticoagulation is first effected, blood cells and molecules of large and medium molecular weight, such as proteins, are then primarily separated from plasma and fed back to the blood stream, regulating a water and salt balance by diverting excess plasma water and further removing from the blood stream, plasma or plasma water accumulated and toxic substances, by removal of specific electrolytes and waste products and wherein purified or partially purified plasma and plasma water is being carried back to the blood tract of the body.

Abstract: An apparatus for cleaning of wastewater comprising a submerged membrane biological reactor system (MBR) and a submerged membrane module (MBD) wherein the MBR is in fluid communication with the MBD for feeding excess sludge from the MBR to the MBD and wherein the MBR comprises an outlet which releases permeate passed through the membrane of the MBR and the MBD is in fluid communication with the MBR for feeding permeate passed through the membrane of the MBD back into the MBR and comprises an outlet for releasing gas.

Abstract: An interconnector coupling permeate conduits in a filtration apparatus includes a diverging section. The diverging section defines a generally increasing cross sectional area for the permeate solution exiting the interconnector in a direction of flow from the permeate conduit of a first separation element to a permeate conduit of a second separation element. The diverging section provides a more gradual divergence of the permeate solution to reduce pressure losses.

Abstract: A fluid separation method for performing fluid analysis of an unfiltered fluid. The fluid separation method includes providing a structure with a fluid analyzer and a power supply. Using a substrate for receiving a fluid flow stream of a multiphase mixture through a fluid sample inlet, wherein the substrate interconnects with the structure. Providing a membrane disposed across the fluid sample inlet for separating a fluid of interest from the multiphase mixture, wherein the fluid flow stream of the multiphase mixture has a shear rate that prevents a fouling of the membrane. Finally, the fluid separation method includes the substrate having fabricated channels, such that the fabricated channels are arranged substantially tangent to the fluid stream downstream of the porous membrane.

Abstract: A membrane separation apparatus in which a membrane clogging is moderated to lower a load to filtering. A plurality of separation membranes 4 are stored vertical and parallel to each other inside the a casing 6 formed with opening sections which respectively open in upper and lower directions thereby configuring a membrane module 3. In a flow passage through which treated water for the membrane module 3 flows, a water flow guide 5 is provided such that an opening area S2 of the flow passage through which treated water outflows is smaller than an opening area S1 of the flow passage through which treated water inflows. Additionally, a plurality of the membrane modules 3 are stacked one upon another in a direction of height of a casing thereby to configure a membrane unit 2. An air diffusing device 7 is disposed below this membrane unit 2 thereby configure a membrane separation apparatus 1.

Abstract: A fuel separation apparatus comprises a stock fuel storage tank storing stock fuel, a separator provided with a separation film separating the stock fuel into high octane value fuel with an octane value higher than the stock fuel and a low octane value fuel with an octane value lower than the stock fuel, and a high octane value fuel storage tank storing the high octane value fuel separated by the separator. When the temperature of the separation film is lower than the high octane value fuel separation temperature, the high octane value fuel stored in the high octane value fuel storage tank is supplied to the separator. Due to this, vaporization of fuel is suppressed and the fuel can be quickly raised in temperature. Due to this, a vehicle mounted fuel separation apparatus able to quickly raise the temperature of the fuel supplied to the separation film so as to quickly raise the temperature of the separation film at the time of engine cold start can be provided.

Abstract: In an embodiment, an automated peritoneal dialysis (“APD”) machine includes at least one pump, a logic implementer storing a plurality of therapy prescriptions by which to operate the at least one pump, each therapy prescription pre-approved for a particular patient, and an input device operating with the logic implementer to allow the patient to select one of the therapy prescriptions for a particular therapy. In another embodiment, the input device operating with the logic implementer allows a doctor/clinician to select or approve one of the therapy prescriptions to be run on the APD machine. In a further embodiment, the logic implementer is programmed to select or suggest one of the therapy prescriptions to be run on the APD machine.

Abstract: A water-on-water filtration system that includes a filter member and two storage vessels. The system includes a plurality of valves that are controlled to place a first of the storage vessels in a fill state in which the first storage vessel is being filled with filtered water, and concurrently place the second of the storage vessels in a service state in which filtered water held in the second storage vessel is delivered as an output of the filtration system. The filtration system can be configured to supply a constant output of filtered water to meet a constant demand while using a relatively small filter member and relatively small storage vessels.

Abstract: A dialysis system including a generally sealed vessel configured to receive a buffer, and a dialysis device positioned in the generally sealed vessel. The dialysis device includes an inner member and an outer member trapping a dialysis membrane between the members. The dialysis device is configured to receive a sample to enable dialysis of the sample with respect to the buffer across the membrane.

Abstract: A method is provided for detecting, measuring or controlling particles and/or electromagnetic radiation, comprising providing a deformable material containing a deformable aperture defining a path for particles or radiation, adjusting the deformable aperture to a prescribed geometry and/or size by deforming the deformable material to change at least one of the parameters of the path defined by the deformable aperture, and causing the particle or radiation to be detected, measured or controlled to enter the deformable aperture. The method includes the step of monitoring the geometry and/or size of the deformable aperture and controlling the adjustment of the size of the deformable aperture in response to such monitoring. The required apparatus is easily fabricated from inexpensive materials.

Abstract: A hollow-fiber membrane assembly having the function of preventing the membrane filaments from cracking, which comprises: hollow-fiber membrane filaments (1), protective film(s) (2) and fastening material (3), wherein the protective film (2) enwraps the outside of the hollow-fiber membrane filament(s) (1) near the end head (5), and a portion of the protective film (2) is immobilized in the fastening material (3), while the rest portion of the protective film (2) outside of the fastening material (3) is left free.

Abstract: The present invention generally relates to hemodialysis and similar dialysis systems, including a variety of systems and methods that would make hemodialysis more efficient, easier, and/or more affordable. One aspect of the invention is generally directed to new fluid circuits for fluid flow. In one set of embodiments, a hemodialysis system may include a blood flow path and a dialysate flow path, where the dialysate flow path includes one or more of a balancing circuit, a mixing circuit, and/or a directing circuit. Preparation of dialysate by the preparation circuit, in some instances, may be decoupled from patient dialysis. In some cases, the circuits are defined, at least partially, within one or more cassettes, optionally interconnected with conduits, pumps, or the like. In one embodiment, the fluid circuit and/or the various fluid flow paths may be at least partially isolated, spatially and/or thermally, from electrical components of the hemodialysis system.

Abstract: A method comprising obtaining a preparation unit comprising a filter module and a collection for each liquid coming from the filter module, with the filter module comprising an inlet compartment as well as an evacuation compartment for the liquids, the filter and collection modules being rotatably mounted relative to each other; disposing the filter and collection modules in a first position; passing a liquid from the filter module to attain the collection module; disposing the filter and collection modules relative to each other in a second position, and passing another liquid from the filter module to attain the collection module.

Abstract: A filtering device incorporating nanoparticles that are known to be capable of destroying bacteria, fungi, viruses, or toxins. The nanoparticles are combined with a filter. The nanoparticles may be pellets adjacent to the filter, a powder of nanoparticles coating at least one side of a filter, or impregnated into a filter. Optionally, two or more filters are contained within an encasement having an inlet and an outlet. Preferably, at least one filter has an electrical charge that is the same as the electrical charge of at least one target particle. Also preferably, coating is accomplished by having a filter to be coated carry an electrical charge that is opposite to an electrical charge carried by the nanoparticles in the powder. Optionally, a filter can be either hydrophobic or hydrophilic.

Abstract: The present invention generally relates to delivery of BMP-7 or functional variants or functional fragments thereof and/or a BMP-7 agonist and methods of use thereof. In some embodiments, methods and devices are provided for delivery of BMP-7 or functional variants or functional fragments thereof and/or a BMP-7 agonist to a patient. In some cases, the BMP-7 or functional variants or functional fragments thereof and/or a BMP-7 agonist may be released in controlled fashion from a device in fluid communication with a patient. In some embodiments, the BMP-7 or functional variants or functional fragments thereof and/or a BMP-7 agonist may be expressed by cells within a device. In other embodiments, methods are provided for improving the function of devices containing renal proximal tubule cells.

Abstract: A spiral wound filter is formed which decreases the cross-sectional area over which the feed fluid flows in order to provide sufficient flow rates across the membrane with less energy consumption, and one embodiment includes a housing that is sealed against substantially the entire outer surface of the filter element.

Abstract: The invention pertains to a device for guiding at least one cable for use in a medical dosing apparatus, which features at least one movable section, characterised in that the device is connected or at least designed to be connected to the at least one movable section of the dosing apparatus permitting movement in tandem. It pertains further to a dosing apparatus, a treatment apparatus, a method for position detection as well as a method to enable or carry out position detection.

Abstract: An extracorporeal filtration and detoxification system and method generally comprise separating ultrafiltrate from cellular components of blood, treating the ultrafiltrate independently of the cellular components in a recirculation circuit, recombining treated ultrafiltrate and the cellular components, and returning whole blood to the patient. A recirculation circuit generally comprises an active cartridge including active cells operative to effectuate a selected treatment; in some embodiments, the active cells are the C3A cell line.

Abstract: A reverse osmosis system and method for operating the same includes a pressure tank having a first end and a second end, the pressure tank has a first volume adjacent to the first end and a second volume adjacent to the second end and a third volume between the first volume and the second volume and a fluid passage fluidically coupling the second volume to the first volume. The reverse osmosis system also includes a plurality of membranes disposed within the third volume generating permeate and a permeate manifold receiving permeate from the membranes and fluidically communicating permeate out of the pressure tank. A feed line couples feed fluid into the pressure tank. A first pump pressurizes the feed line. A second pump is disposed within the tank and circulates brine fluid from the second volume through the fluid passage.

Abstract: This invention relates to filtration assemblies and methods of installing filtration units in filtration assemblies. Filtration assemblies may include first and second end pieces, at least one filtration unit between the first and second end pieces, and at least one alignment rod arrangement. The alignment rod arrangement may extend between the end pieces and align the filtration units and the end pieces.

Abstract: A dialysis supply system that includes a central dialysis liquid manufacturing unit, a dialysis treatment unit, a valve arrangement, and a hydraulic module.

Abstract: An apparatus and a method for monitoring the supply of replacement fluid during an extracorporeal treatment of blood is disclosed. Detection of the supply of replacement fluid upstream or downstream of the dialyser or filter is based on a measurement of the optical or physical density of the blood or of a constituent of blood in the extracorporeal circulation. To detect pre- or post-dilution, the blood flow rate and/or the replacement rate and/or the flow rate of the fluid removed from the blood through the dialyser membrane is altered, and the density of the blood or of the constituent of blood is measured upstream and/or downstream of the dialyser. Additionally, an apparatus for treating blood with an apparatus for monitoring the supply of replacement fluid is disclosed.

Abstract: Equipment, systems, processes and techniques for conducting reverse osmosis processing of solutions are described. The techniques can be applied to provide diluted solution (i.e. purified solvent), concentrate solution or each. A variety of specific equipment, example systems and processes are depicted and described.

Abstract: A vehicle-mounted fuel separation system 24 is provided with a fuel heating device 56 heating stock fuel and a separator 57 separating stock fuel heated by the fuel heating device into a plurality of types of fuel. Furthermore, a forced exhaust device 66 forcibly exhausting the fuel in the fuel heating device from the fuel heating device when the temperature of the fuel in the fuel heating device becomes a reference temperature or more or is expected to become a reference temperature or more is provided. Due to this, a fuel separation system where excessive heating of the fuel by the fuel heating device of the fuel separation system is prevented is provided.

Abstract: Various embodiments described herein provide methods and apparatus for producing purified water from sea water or some other salty or brackish water source by using brackish concentrate mixed with salty water. The various embodiments also provide methods and apparatus for the treatment of toxicity of brackish concentrate, which brackish concentrate exhibits on aquatic life inhabiting the area of discharge of the brackish concentrate, as well as a method for environmentally safe disposal of brackish concentrate.

Abstract: A method and device for blood treatments that use fluids such as dialysate and replacement fluid for renal replacement therapy. In an embodiment, fluid is passed either by pump or passively by gravity feed, through a microporous sterilization filter from a fluid source to a replacement fluid container. The latter forms a batch that may be used during treatment. The advantage of forming the batch before treatment is that the rate of filtering needn't match the rate of consumption during treatment. As a result, the sterilization filter can have a small capacity. In another embodiment, a filter is placed immediately prior to the point at which the sterile fluid is consumed by the treatment process. The latter may be used in combination with the former embodiment as a last-chance guarantee of sterility and/or that the fluid is free of air bubbles. It may also be used as the primary means of sterile-filtration.

Abstract: The present invention relates to a pump rotor for a peristaltic hose pump, in particular a medical peristaltic hose pump, with at least one actuating device, by means of which the pump rotor can be actuated hydraulically and/or pneumatically. Furthermore the present invention in particular relates to a medical peristaltic hose pump and to a method for actuating a pump rotor of a peristaltic hose pump.

Abstract: Device designed to desalinate brackish water which performs said function by the combined action of magnetic fields generated inside the device and ion-selective membranes, thus obtaining two separate water currents, one with a low salt concentration and the other reject current with a high salt concentration. It comprises an external cylindrical body of magnetized iron (1), an inner body also cylindrical and made of the same material (2) and an intermediate chamber (3) in which are placed a series of ion-selective membranes (6 and 7) arranged radially around the axle common to all of the bodies, and placed alternately such that each negative-ion selective membrane has a positive-ion selective membrane on either side.

Abstract: Sea water is not suitable for human consumption. Naturally present dissolved chemicals in sea water make it inconsumable. The precipitants and dissolved chemicals need to be separated from water to make it consumable. A combination of aeration system, filtration system, crystallizer, hydrophobic membrane carrying filter and pressure retarded osmosis system are used in various combination to desalinate the sea water. Pressure retarded osmosis process is also used to produce pressurized diluted brine which is further decompressed to by the turbine and used by the generators to produce electricity. Various heat exchange apparatus are used for energy conservation and efficient processing of water in a feasible way. The disclosure enables to purify water and provide an economical means for producing electricity.

Abstract: In the present invention, dialysis tubing is placed in a chamber, where an ultrasonic or a other mist producer is present. The ultrasonic mist producer will produce mist and small water droplets will be attached to the surface of dialysis membrane (sheet or tubing) and will condense and the water drops will fall back in the solution tank, where the ultrasonic probe produces the mist. When the droplet is attached to the membrane surface, the dialysis will take place.

Abstract: A water purification unit to purify potentially contaminated water is provided. The water purification unit is in fluid communication with a water source and has a pump to draw water from the water source. The water is passed through at least a main filter to purify the water and dispensed through an outlet. Power is provided to the water purification unit by a battery bank and a non-grid power source.

Abstract: Water purification system comprising filtration media sized with respect to each other to allow a first contaminant in the water to saturate the first medium with a delay prior to saturation of the second medium with a second contaminant.

Abstract: The present application discloses a membrane stack comprising a first and second membrane layers, and a spacer layer disposed between said first and second membrane layers, said membrane stack configured such that fluid passes through said membrane stack in a direction substantially perpendicular to the plane of said membrane layers and said spacer layer. The application also discloses a module comprising a membrane as described above, said module having a fluid flow path that is substantially perpendicular to the plane of the major surface of the membrane and spacer layers in said membrane stack.

Abstract: An apparatus for extracorporeal blood treatment has a dialysis fluid circuit and a blood circuit which are separated by a dialyzer. Arranged in the dialysis fluid circuit there is a sterile filter for producing a sterile dialysis fluid which flows into the dialyzer. To check the sterile filter, a chemical and/or physical property of the dialysis fluid, for example the conductivity, is changed upstream of the sterile filter, and the change in the property of the dialysis fluid is detected downstream of the sterile filter. From the time shift between the initiation of the conductivity impulse and the detection of the latter, it is possible to tell whether the blood treatment apparatus is fitted with a sterile filter. Moreover, the volume of the sterile filter can be inferred from the length of the time shift.

Abstract: The present invention relates to bioartificial devices and systems that mimic kidney or nephron function and methods of making them.

Abstract: A pump assembly to move water past a reverse osmosis membrane, said pump assembly having a first pump (10A) and a second pump (10B) each pump including: a bore having a longitudinal axis and surrounding a chamber; a first partition member extending longitudinally of the chamber; a second partition member (17) also extending longitudinally of the chamber and moveable relative to the first partition member, and dividing said chamber into a first sub chamber (18) and a second sub chamber (19); a shaft (15) attached to said second member to cause angular movement thereof about said axis to change the volumes of said first and second sub chambers; and ducting communicating with said first and second sub chambers to provide for the flow of water with respect thereto as the volumes are varied; and wherein the shaft of said first pump is coupled to the shaft of said second pump so that the first pump second partition (17A) angularly oscillates in phase with the second pump second partition (17B).

Abstract: The present invention relates to a method for filtering blood to produce plasma or serum and to a blood filter for the production of plasma or serum from a blood sample. The invention further relates to a kit comprising a blood filter for the production of plasma or serum from a blood sample and a syringe.

Abstract: The invention relates to a microfluidic apparatus for producing a volume flow that is uniform over time in a metering process. In various solution processes or reaction processes it is essential to have a specified given volume flow or mass flow of fluid available to ensure reliable dissolution of the reagent or ensure that the reaction takes place. In microfluidic apparatus in which separation of particles from a fluid, particularly blood, is carried out through a membrane, the volume flow through the membrane decreases continuously. In order to achieve a uniform volume flow during metering, it is envisaged that first of all a reservoir is filled from a first channel, so that the contents of the reservoir can then be fed to the metering process by opening a fluid stop. The emptying of the reservoir takes place with a uniform volume flow of 0.05 microlitres per second to 10 microlitres per second.

Abstract: Tangential flow filtration device is provided wherein liners are provided between the filtration element and the top and bottom holders or manifolds. The liners incorporate the flow channels and inlet and outlet ports that were previously present in the manifolds. The liners are made of an inexpensive material and therefore are disposable after a single use, making it more cost effective to dispose of them than to clean the conventional manifolds. In addition, the liners can be pre-sterilized.

Abstract: An apparatus for passive sorting of microdroplets including a main flow channel, a flow stream of microdroplets in the main flow channel wherein the microdroplets have substantially the same diameter and wherein the flow stream of microdroplets includes first microdroplets having a first degree of stiffness and second microdroplets having a second degree of stiffness wherein the second degree of stiffness is different than the first degree of stiffness. A second flow channel is connected to the main flow channel for the second microdroplets having a second degree of stiffness. A separator separates the second microdroplets having a second degree of stiffness from the first microdroplets and directs the second microdroplets having a second degree of stiffness into the second flow channel.