Abstract: The invention relates to a method for reducing the number of leukocytes in blood through treating the blood in an arrangement of a plurality of fibers based on organic polymers, whereby the blood is channeled along the fibers and whereby the reduction in leukocytes from the blood occurs essentially through adsorption on the fibers, characterized in that the plurality of fibers based on organic polymers is fixed in a housing with an inlet arrangement and an outlet arrangement, and that the blood is channeled via the inlet arrangement into the housing, flows through the housing with the plurality of fibers made from organic polymers, and exits the housing via the outlet arrangement, that the arrangement of the fibers shows a high degree of order, that the blood flows along the external surface of the fibers, and that the fibers cause a generation of the complement activation product C5a in a concentration of at least 10 ?g per m2 of fiber surface.

Abstract: A device and a method for a peritoneal dialysis treatment having several cycles include a cycler controlled by a processor. The cycler fills the abdominal cavity with dialysis fluid, and drains the abdominal cavity. A sensor senses a variable related to the draining of the dialysis fluid. The draining is interrupted when the variable reaches a breakpoint at which the variable is radically changed, thereby leaving the residual volume of fluid.

Abstract: A hollow fiber membrane type fluid treatment device having at least a body portion of tubular housing containing a hollow fiber membrane bundle. In the hollow fiber membrane type fluid treatment device, an inner surface of a body portion of the tubular housing at a side of a treatment liquid inlet has a body straight portion and an end tapered portion which increases in diameter toward an end face of the housing body portion, the hollow fiber membrane is arranged so that a distance between the hollow fiber membranes is gradually increased toward the end face on the treatment liquid inlet side along a taper of a tapered portion of the inner surface of the housing body portion, and a liquid to be treated flows within the hollow fiber membranes and a treatment liquid flows outside of the hollow fiber membranes.

Abstract: A method of removing leukocytes that through reducing of clogging of a leukocyte removing filter element by blood cell components and plasma proteins being a problem encountered at the time of removing leukocytes from blood, shortens the filtration time at refrigerated filtration and exhibits high leukocyte removing performance at room temperature filtration. There is provided a method of removing leukocytes including filtering blood containing leukocytes through a leukocyte removing filter apparatus having multiple fibrous filter elements with different average fiber diameters to thereby remove leukocytes from the blood, characterized in that use is made of a leukocyte removing filter apparatus wherein the multiple fibrous filter elements include at least leukocyte removing filter element (A) of 2.0 to <4.0 ?m average fiber diameter and leukocyte removing filter element (B) of 0.7 to 1.

Abstract: A method and a device for supply of a dialyser in a dialysis unit with dialysis fluid is disclosed. At least one dialysis fluid concentrate is mixed with water to produce the dialysis fluid. The dialysis fluid concentrate is prepared in a reservoir unit in a given amount. A control and arithmetic unit calculates the dialysis fluid rate (Qd) such that, after a given treatment time (TB) has passed, a given residual amount of dialysis fluid concentrate or no residual amount remains in the reservoir unit. It is preferable to empty the reservoir unit by the end of treatment.

Abstract: A blood treatment apparatus includes: a blood treatment unit, a pair of fluid pumps and a pair of blood pumps. The blood treatment unit is configured to receive untreated blood and fresh blood treatment fluid, and emit treated blood and used blood treatment fluid. The fluid pumps are configured to pass blood treatment fluid through the blood treatment unit. The blood pumps are configured to extract untreated blood from a blood source, pass extracted blood through the blood treatment unit and deliver treated blood to a target vessel. Flow measurement device which determines at least one blood flow parameter reflecting an average flow in relation to the blood treatment unit during a well-defined period of operation of the apparatus, for example while completing one operation cycle.

Abstract: A microfluidic fluid separator for separating target components of a fluid by filtration is described. Methods for separating target components of a fluid by filtration and methods for processing blood on a large scale with the microfluidic fluid separator are provided.

Abstract: The present invention relates to a means of dialysis for removing protein-bound substances from a biological fluid, especially blood or blood plasma, which contains at least one means for solubilizing protein-binding substances to be removed into the biological fluid and/or dialysis fluid, and to a process for removing protein-bound substances from a biological fluid.

Abstract: An extracorporeal blood processing method using a blood circuit comprising a pair of blood passages attached to opposite flow ends of a blood treatment device and said blood circuit is mounted on a blood pump console, the method includes: withdrawing blood from a vascular system of a human patient and drawing the blood into the blood circuit; pumping the withdrawn blood through one of the pair of blood passages using a first blood pump of the console and into the blood treatment device; pumping the treated blood from the treatment device through the other of the pair of blood passages using a second blood pump of the console; infusing the treated blood from the other blood passage and into the vascular system of the patient, and periodically reversing a flow direction of blood through the pair of blood passages and blood treatment device.

Abstract: A device, system and method for exchanging components between first and second fluids by direct contact in a microfluidic channel. The fluids flow as thin layers in the channel. One of the fluids is passed through a filter upon exiting the channel and is recycled through a secondary processor which changes the fluid's properties. The recycled fluid is reused for further exchange. The filter excludes blood cells from the recycled fluid and prevents or limits clogging of the filter. The secondary processor removes metabolic waste and water by diafiltration.

Abstract: A first connector of a connector assembly of a sterile batch container can be unsealed. The connector assembly can be attached to a filling port of the sterile batch container and can have a sterile filter arranged between the filling port and the first connector. The first connector can be coupled so as to receive produced purified water. A transmembrane pressure can be monitored across the sterile filter while flowing the purified water through the connector assembly into the sterile batch container so as to provide a sterile fluid stored therein. The connector assembly can be detached from the filling port of the sterile batch container. After the detaching, the sterile batch container can be coupled to the blood treatment system. In response to a change in the transmembrane pressure exceeding a predefined level, an alarm signal can be generated.

Abstract: A method and device that identify impairments of the blood flow in an extra-corporeal blood circuit during extracorporeal treatment of the blood using an extracorporeal haemodialysis device, where the phase angle of at least one harmonic oscillation of an oscillating pressure signal that propagates in the extracorporeal blood circuit is determined. Impairments of the blood flow are detected in the extracorporeal blood circuit based on a characteristic modification of the phase angle of at least one harmonic oscillation of the pressure signal. A temporal modification of the phase angle may be compared with a predefined threshold value and an impairment is detected if the value of the modification of the phase angle is greater than the predefined threshold value. The method and device permit an early identification of a coagulation of the blood that flows through the haemodialysis unit, so that countermeasures can be initiated promptly.

Abstract: Devices, systems, and methods are provided for controlling an inflammatory response in a subject. Devices, systems, and methods are provided that alter the functional structure of one or more inflammatory mediators in the peripheral blood of the subject. The device or system is useful in a method for treating an inflammatory disease or condition in the subject.

Abstract: A method is disclosed for filtering a protein in a liquid mixture in a manner that does not substantially damage or otherwise limit the recovery of the protein in the filtration filtrate. The method generally includes passing a liquid mixture containing a protein (e.g., an aqueous vWF mixture) through a filter while applying a counter pressure to the liquid mixture filtrate to accurately reduce and control the pressure differential across the filter. The disclosed method has the advantage that relatively high filtration flow rates can be achieved at relatively low pressure differentials, in contrast to high pressure differentials, which actually reduce the filtration flow rate of protein liquid mixtures. Further, the method can recover substantially all of the protein that is initially present in the liquid mixture.

Abstract: The blood bag system includes: a blood treating filter for treating a blood; a first bag for containing therein a blood to be supplied to the blood treating filter; a second bag for containing therein the blood treated by the blood treating filter; storage solution supply which supplies a blood component storage solution to the blood treating filter; a third bag into which a blood remaining in the blood treating filter replaced by the blood component storage solution is transferred and in which the recovered blood is temporarily contained; and a fourth bag to which a blood component separated from the treated blood contained in the second bag is transferred and in which the transferred blood component is contained.

Abstract: A renal therapy blood cleaning system includes: a blood filtering device in communication with an extracorporeal circuit; a first pump configured to pump fluid to the blood filtering device; a second pump configured to pump fluid from the blood filtering device; a balance chamber in fluid communication with first and second lines, the first and second lines in fluid communication with the first and second pumps, respectively, the balance chamber configured to exchange like volumes of fresh and spent fluid; a plurality of valves; and a control scheme programmed to operate the plurality of valves to enable spent fluid taken from the balancing chamber through one of the first and second lines to be recirculated to the balance chamber through the other of the first and second lines to compensate for a volume of fresh fluid delivered to the blood filtering device.

Abstract: Devices, systems, and methods are provided for controlling an inflammatory response in a subject. Extracorporeal devices, systems, and methods are provided that alter the functional structure of one or more inflammatory mediators in the peripheral blood of the subject. The device or system is useful in a method for treating an inflammatory disease or condition in the subject.

Abstract: A connecting device comprises a buffer chamber (2), a first connecting line (3) between a liquid source (4) and an inlet (5) of the buffer chamber, a second connecting line (9) between an outlet (10) of the buffer chamber and the medical treatment apparatus (11), two valves (7, 8) arranged in series on the first connecting line, a pump (12) on the second connecting line, two liquid level sensors (15, 16) operating in the buffer chamber, a vent valve (18) connected to the buffer chamber. The liquid source is a centralized distribution plant of dialysate, while the medical treatment apparatus is a dialysis apparatus. The invention prevents back-contamination of the centralized plant with disinfectant sourced from the dialysis apparatus.

Abstract: Systems and methods for the washing and processsing of biological fluid/biological cells are disclosed. The systems and methods prevent inadvertent target cell loss by monitoring pressure and providing for the dilution of the cell feed.

Abstract: The present invention is directed to degassing devices for dialysate circuits. One embodiment has a first housing and a second housing positioned within the first housing in an annular relationship. A second embodiment comprises a dialysate regeneration system with urease, a dialyzer, and a housing with an external wall, where the external wall is exposed to atmosphere and comprises a material that passes gas but does not pass liquid and where the housing is positioned between the urease and dialyzer.

Abstract: A method and a device for differentiation of substances in a body fluid, such as blood, plasma or used peritoneal dialysis fluid, for example for hemodialysis. The device has a compartment having several inlets for entering a body fluid, a transition fluid and a diffusion fluid for flowing parallel with each other in laminar flow layers with substantially equal flow velocities. The transition fluid layer is interposed between the body fluid layer and the diffusion fluid layer. The compartment further has a first outlet for removing the body fluid and the transition fluid and a second outlet for removing the diffusion fluid. Pumps are arranged for controlling the flow velocities so that a marker substance, such as albumin, will not diffuse from the body fluid layer across the transition layer, during the passage of the body fluid from the inlet to the outlet of the compartment.

Abstract: An apparatus and a method for filling a container containing a dry powdered salt concentrate for use in dialysis with purified fluid and removing the trapped air or gases generated during the filling of the container, while maintaining the required fluid level in the container and without the need for evacuating gases from the container prior to filling.

Abstract: The present invention relates to systems and devices to treat and/or prevent inflammatory conditions within a subject and to related methods. More particularly, the invention relates to systems, devices, and related methods that sequester leukocytes and/or platelets and then inhibit their inflammatory action.

Abstract: Dialysis systems comprising actuators that cooperate to perform dialysis functions and sensors that cooperate to monitor dialysis functions are disclosed. According to one aspect, such a hemodialysis system comprises a user interface model layer, a therapy layer, below the user interface model layer, and a machine layer below the therapy layer. The user interface model layer is configured to manage the state of a graphical user interface and receive inputs from a graphical user interface. The therapy layer is configured to run state machines that generate therapy commands based at least in part on the inputs from the graphical user interface. The machine layer is configured to provide commands for the actuators based on the therapy commands.

Abstract: A combination of acid zirconium phosphate and alkaline hydrous zirconium oxide are utilized as ion-exchange materials, for example, in sorbent dialysis. The combination provides for dialysate regeneration while maintaining constant and controlled levels of Na+, HCO3?, and pH.

Abstract: A device is provided for transferring mass and/or exchanging energy between two media, particularly between blood and a gas/gas mixture. The device includes a chamber (2), through which the first medium flows and inside which at least one mass-permeable and/or energy-permeable hollow fiber (5), preferably a plurality of mass-permeable and/or energy-permeable hollow fibers (5), is/ are arranged. The second medium can flow through the at least one hollow fiber (5), while the first medium can flow therearound. At least one pumping element (5), which allows the first medium to be displaced from the chamber (2) and/or to be sucked into the chamber (2), is disposed in the chamber (2) of the device.

Abstract: The invention relates generally to methods of concentrating mixtures including shear sensitive biopolymers, such as von Willebrand Factor. Conventional methods of concentrating biopolymers impart too much shear stress, which causes the degradation of shear sensitive biopolymers. The methods disclosed herein reduce the shear stress while maintaining a high rate of filtrate flux. Disclosed herein is a method for concentrating shear sensitive biopolymers including flowing a mixture with a shear sensitive biopolymer into a hollow fiber dialysis module to form a retentate having a shear sensitive biopolymer concentration that is greater than that of the mixture. Hollow fiber dialysis modules have high filtrate fluxes and low shear rates at low flow rates. This ensures a high product yield and minimal loss of shear sensitive biopolymers.

Abstract: Disclosed herein are methods for treating amyloid disease in humans by clearing amyloid peptides from one or more bodily fluids such as, e.g., blood, of a patient. In particular, the methods are based on the administration of compounds capable of binding to amyloid-beta (A?) or on dialysis of blood or plasma exchange in order to remove A? peptides from the blood circulation, and/or brain or other affected organs.

Abstract: The invention concerns a method for treating a fluid. According to the invention, the fluid is contacted with a substrate at the surface of which there is a network of organic molecules, hereafter referred to as “network molecules”. There is a central core and at least one lateral arm, the molecules being adsorbed at the surface of the substrate. The invention also concerns a two-dimensional molecular sieve formed by the substrate at the surface of which a network of network molecules is adsorbed. The invention further concerns a module for treating a fluid including a circulating device for the fluid to be treated, the device containing one or more two-dimensional molecule sieves.

Abstract: This invention provides an apparatus and methods to consistently separate and concentrate selected blood components. The system includes, e.g., a computerized fluid handling system to transfer blood components between a centrifugal blood separation disc, containers and a concentrator.

Abstract: Biological fluid filtration systems including biological fluid filtration devices capable of filtering blood or blood products, including the removal of leukocytes from the blood or blood product. Each system includes a means to automatically drain the biological fluid upstream of the biological fluid filtration media disposed in the biological fluid filtration device. Both single sided and double sided biological fluid filtration devices are disclosed, including double sided biological fluid filtration devices with a solid partition wall with a first independent fluid flow path on one side of the partition wall, and a second independent fluid flow path on the other side of the partition wall. Draining means include vent filtration devices, diaphragm draining devices, and biological fluid filtration devices that include an integral diaphragm.

Abstract: The present invention includes a separable test tube for use in a centrifugal separator that does not need to separately transfer separation liquid to another test tube for a second separation after a first separation. The separable test tube includes a first tube including a first coupling portion, a second coupling portion, and an adjustment portion. A second tube includes a first body part, a first space portion, a first packing fastener, a third coupling portion which engages the first coupling portion, and an adjustment groove into which the adjustment portion is inserted. A third tube includes a second body part having a second space portion, a second packing fastener, and a fourth coupling portion which engages the second coupling portion. First and second watertight members are coupled to the first and second coupling portions, respectively. First and second packings are coupled to the first and second packing fasteners, respectively.

Abstract: A biological fluid filtration device, system, and method, for filtering a biological fluid, the device comprising a housing having an inlet, a first outlet and a second outlet, with a first fluid flow path defined between the inlet and the first outlet, with a second fluid flow path defined between the inlet and the second outlet, with a first biological fluid filtration media interposed between the inlet and the first outlet and across the first fluid flow path, with a second biological fluid filtration media interposed between the inlet and the second outlet and across the second fluid flow path, the housing essentially lacking a solid partition wall between the first biological fluid filtration media and the second biological fluid filtration media, a first flow restriction may be added downstream of the first biological fluid filtration media, and a second flow restriction may be added downstream of the second biological fluid filtration media, in another embodiment, the device comprises a housing having

Abstract: An extracorporeal blood therapy control unit housing has a first and second manually mounted panels and spring loaded components configured for releasably engaging and tensioning the said panels against a side of said housing. The first and second panels have arch-shaped tubing segments mounted on the interior side of said respective panels. Each of the tubing segments are held in operational engagement with a different peristaltic pump rotor by the panel engaging and tensioning components.

Abstract: Devices, systems, and methods are disclosed herein for modulating the levels of one or more target components in the blood and/or lymph of a vertebrate subject for treatment of a disease or condition in the vertebrate subject. An implantable device is provided which includes a body defining at least one lumen configured for fluid flow; at least one first reservoir in communication with at least one lumen; one or more energy sources configured to provide energy to elicit one or more signal responses associated with one or more labels that bind to one or more target components in one or more of blood fluid or lymph fluid of the vertebrate subject; one or more sensors configured to detect the one or more signal responses associated with one or more labeled target components; and one or more reactive components in communication with the at least one lumen for release responsive to the one or more sensors.

Abstract: Devices, systems, and methods are described herein for controlling or modulating the levels of one or more target components in the blood and/or lymph of a vertebrate subject. Devices and systems are provided that include a body defining at least one lumen configured for fluid flow; at least one controllable flow barrier to fluid flow into the at least one lumen; at least one first reservoir disposed within the body and configured to include one or more bifunctional tags, wherein the one or more bifunctional tags are configured to selectively bind to one or more target components in one or more of blood fluid or lymph fluid of a vertebrate subject; at least one treatment region disposed within the at least one lumen; and at least one second reservoir disposed in the at least one treatment region and configured to include one or more reactive components, wherein the one or more reactive components are configured to sequester the one or more bifunctional tags when bound to the one or more target components.

Abstract: A cardiotomy and venous blood reservoir, including a housing assembly, a venous inlet port, a venous sub-assembly, a cardiotomy inlet port, and a cardiotomy sub-assembly. The housing forms a chamber. The venous sub-assembly includes a downtube and a bowl. A diameter of the downtube lumen increases to a downstream end. The bowl forms a floor surface for receiving flow from the lumen. The cardiotomy sub-assembly includes a dish and an inner post. The dish defines an aperture. The inner post extends from the dish and forms a guide surface received within the central aperture and forming an undulating curvature increasing to a diameter greater than the diameter of the central aperture. Cardiotomy liquid drops from the dish fall on to the undulating, closely positioned guide surface with minimal splashing.

Abstract: An apparatus for carrying out selected fluid management and/or renal replacement patient therapy is characterized by an interactive operator control system having operator inputs for selectively changing a panel kit, replacing a filter cartridge, and/or changing to a different patient therapy during a currently running patient therapy, and providing operator instructions for carrying out tasks for completing same. In one embodiment, the interactive operator control system is also characterized by automatically serially identifying different setup steps to be carried out during system setup, displaying the successive steps substantially throughout the system setup as well as displaying on the operator interface screen sequential tasks to be carried out for each of the different setup steps.

Abstract: A method for controlling an apparatus for treating blood outside the human body, with a view to improving the operation of the apparatus, the apparatus including a semi-permeable membrane carrying out an exchange of solutes, referred to as dialysis, and of liquid, referred to as ultrafiltration, with the blood, the method including at least one iteration of the following steps: determination of a so-called instantaneous value, of an ultrafiltration coefficient corresponding to the ratio of an ultrafiltration flow rate to a difference in pressure, the so-called transmembrane pressure, on either side of the semi-permeable membrane, comparison of the instantaneous value with at least one previously determined characteristic value; and control of the treatment apparatus to reach a maximum value of the ultrafiltration coefficient, the control including a variation of the ultrafiltration flow rate up to a value corresponding to the maximum value of the ultrafiltration coefficient.

Abstract: A method for exchanging heat between an effluent fluid and a treatment fluid and a heat exchanger for heat exchange as well as an arrangement and a kit comprising a heat exchanger. The heat exchanger comprises a first and a second fluid circuit extending through the heat exchanger. The heat exchanger further comprises a stack of fluid plates and a membrane arranged between each of the fluid plates where one interspace is formed between each fluid plate and membrane. The first and the second fluid circuit is each constituted by a passage extending through the fluid plates and membranes and along the fluid plates and membranes in at least two interspaces. According to the method for heat exchanging an effluent fluid is passed through the first fluid circuit and a treatment fluid is passed through the second fluid circuit such that the effluent fluid is passed along one side of a membrane and simultaneously the treatment fluid is passed along the other side of the membrane.

Abstract: A method for exchanging heat between an effluent fluid and a blood fluid and a heat exchanger for heat exchange. The heat exchanger comprises a first and a second fluid circuit extending through the heat exchanger. The heat exchanger further comprises a stack of fluid plates and a membrane arranged between each of the fluid plates where one interspace is formed between each fluid plate and membrane. The first and the second fluid circuit is each constituted by a passage extending through the fluid plates and membranes and along the fluid plates and membranes in at least two interspaces According to the method for heat exchanging an effluent fluid is passed through the first fluid circuit and a blood fluid is passed through the second fluid circuit such that the effluent fluid is passed along one side of a membrane and simultaneously the blood fluid is passed along the other side of the membrane. Heat is thus exchanged between the effluent fluid and the blood fluid over the membrane.

Abstract: The present invention relates to novel methods and compositions for detection and isolation of cancer cells with metastatic potential. The invention further relates to assays for measuring the metastatic potential of such cancer cells and drug screening assays for the identification of agents having anti-metastatic potential. The present invention further provides methods and compositions for inhibiting the metastatic potential of cancer cells by modulating the activity of serine integral membrane proteases [(SIMP) consisting of seprase and dipetidyl peptidase IV (DPPIV)] expressed on the surface of metastasizing cancer cells.

Abstract: An optical blood monitoring system with a ratiometric model determines hematocrit values for a hemodialysis patient, from which hemoglobin values for the patient are estimated. The ratiometric model is calibrated, normally against a cell counter, using blood from a blood bank. The blood from a blood bank is preserved in a long term preservative which is typically different than that found in clinical settings. The hematocrit value determined by the ratiometric model is scaled by scaling factor so that the estimated hemoglobin level output from the monitor consistently matches that measured in a clinical setting. The hematocrit scaling factor is substantially about 1.033 when the patient's blood sample is stored in a short term preservative ethylene diamine tetra acetic, and is substantially about 1.06 when the hematocrit is measured in the blood sample without preservative being added to the blood sample. The hemoglobin value can also be adjusted for altitude.

Abstract: A dialysis system includes: a dialysis machine for performing a first dialysis session on a patient at a first time of a day; a remote exchange device for performing a second dialysis session on the patient at a second time of the day, the remote exchange device configured to record an amount of ultrafiltration (“UF”) that is removed from the patient over the second dialysis session; and a communication link between the dialysis machine and the remote exchange device, wherein the dialysis machine is configured to receive the recorded amount UF removed from the remote exchange device via the communication link and determine a total amount of UF removed from the patient over the first and second sessions.

Abstract: A method and a system for regenerating a body fluid, such as a peritoneal dialysis fluid. The body fluid is removed into an extracorporeal circuit comprising an electrofilter for removing charged ions from the body fluid, a nanofilter for removing large molecules, such as Dextran 40, and a reverse osmosis filter for concentrating the body fluid, for producing a synthetic urine to be discarded. The removed ions and large molecules are returned to the patient together with pure water from the reverse osmosis filter through an ultrafilter.

Abstract: The present disclosure describes devices useful for microscale fluid purification, separation, and synthesis. Such devices generally comprise a fluid membrane that separates two or more fluids flowing through plural microchannels operatively associated with the membrane. Often, the membrane is a semipermeable membrane, such as might be used with a filtration device, such as a dialyzer. Devices of the present invention can be combined with other microscale devices to make systems. For example, the devices may be coupled with one or more microchemical microfactories, one or more micromixers, one or more microheaters, etc. Examples of devices made according to the present invention included an oxygenator, a dialyzer, microheat exchangers, etc.

Abstract: A method and apparatus for controlling blood withdrawal and infusion flow rate with the use of a pressure controller. The pressure controller uses pressure targets based upon occlusion limits that are calculated as a function of flow. The controller has the ability to switch from controlling withdrawal pressure to controlling infusion pressure based upon the detection of an occlusion. The controller distinguishes between partial and total occlusions of the withdrawal vein providing blood access. Depending on the nature of occlusion, the controller limits or temporarily reverses blood flow and, thus, prevents withdrawal vessel collapse or reverses blood flow to quickly infuse blood into the vessel without participation from operator.

Abstract: A device, system and method for exchanging components between first and second fluids by direct contact in a microfluidic channel. The fluids flow as thin layers in the channel. One of the fluids is passed through a filter upon exiting the channel and is recycled through a secondary processor which changes the fluid's properties. The recycled fluid is reused for further exchange. The filter excludes blood cells from the recycled fluid and prevents or limits clogging of the filter. The secondary processor removes metabolic waste and water by diafiltration.

Abstract: The present invention relates to systems and devices to treat and/or prevent inflammatory conditions within a subject and to related methods. More particularly, the invention relates to systems, devices, and related methods that sequester leukocytes and/or platelets and then inhibit their inflammatory action.

Abstract: Devices, systems, and methods are described herein for controlling or modulating the levels of one or more target components in the blood and/or lymph of a vertebrate subject. Devices and systems are provided that include a body defining at least one lumen configured for fluid flow; at least one controllable flow barrier to fluid flow into the at least one lumen; at least one first reservoir disposed within the body and configured to include one or more bifunctional tags, wherein the one or more bifunctional tags are configured to selectively bind to one or more target components in one or more of blood fluid or lymph fluid of a vertebrate subject; at least one treatment region disposed within the at least one lumen; and at least one second reservoir disposed in the at least one treatment region and configured to include one or more reactive components, wherein the one or more reactive components are configured to sequester the one or more bifunctional tags when bound to the one or more target components.