Including Liquid Flow Diversion Patents (Class 210/659)
  • Patent number: 10005006
    Abstract: The invention relates to a method for setting a gradient delay volume GDV of a liquid chromatography system for a chromatography run in liquid chromatography, in particular a high-performance liquid chromatography system, in which a desired value GDVtarget of a gradient delay volume of the liquid chromatography system is ascertained or predefined and, if the value GDVtarget deviates from a specific fixed value GDVactual of a liquid chromatography system, this value GDVtarget is set in a range 0??GDV=GDVtarget?GDVactual?Vmax of a volume of a volume adjustment device 5. Furthermore, the invention relates to an automatic sampler for carrying out such a method.
    Type: Grant
    Filed: March 18, 2015
    Date of Patent: June 26, 2018
    Assignee: DIONEX SOFTRON GMBH
    Inventors: Hermann Hochgraeber, Thomas Wachinger
  • Patent number: 9522862
    Abstract: A simulated moving bed separator and methods for isolating a desired component are provided. A method includes removing an extract from an extract bed of the simulated moving bed separator, where the extract includes the desired component, and where the simulated moving bed separator includes a plurality of adsorbent beds circularly coupled together. The simulated moving bed separator also includes a distributor and a plurality of conduits fluidly coupling the distributor to the adsorbent beds. The adsorbent beds include the extract bed and a secondary flush bed downstream from the extract bed. A secondary flush conduit is flushed with a secondary flush fluid while removing extract from the extract bed, where the secondary flush conduit fluidly couples the secondary flush bed with the distributor. The flush fluid includes the extract.
    Type: Grant
    Filed: June 30, 2014
    Date of Patent: December 20, 2016
    Assignee: UOP LLC
    Inventor: Robert Edward Sanders
  • Patent number: 9416880
    Abstract: A rotary metering valve assembly includes a stationary body plate having a first contact surface. Also included is a valve plate having a second contact surface disposed in contact with the first contact surface of the stationary body plate, wherein the valve plate is configured to rotate relative to the stationary body plate. At least one of the first contact surface and the second contact surface comprises a surface flatness of less than about 2.4 ?m (about 93 ?in) and a surface roughness of at least about 0.2 ?m (about 8 ?in).
    Type: Grant
    Filed: February 21, 2014
    Date of Patent: August 16, 2016
    Assignee: HAMILTON SUNDSTRAND CORPORATION
    Inventors: Kevin M. Rankin, Peter M. Ballard, Todd Haugsjaahabink, Glen A. Pruden
  • Patent number: 9260677
    Abstract: The present invention provides a chromatographic separation process for recovering a polyunsaturated fatty acid (PUFA) product from a feed mixture, which process comprises the steps of: (i) purifying the feed mixture in a first separation step in a simulated or actual moving bed chromatography apparatus having a plurality of linked chromatography columns containing, as eluent, an aqueous organic solvent, to obtain an intermediate product; and (ii) purifying the intermediate product obtained in (i) in a second separation step using a simulated or actual moving bed chromatography apparatus having a plurality of linked chromatography columns containing, as eluent, an aqueous organic solvent, to obtain the PUFA product; wherein (a) the first and second separation steps are carried out sequentially on the same chromatography apparatus, the intermediate product being recovered between the first and second separation steps and the process conditions in the chromatography apparatus being adjusted between the first an
    Type: Grant
    Filed: July 6, 2012
    Date of Patent: February 16, 2016
    Assignee: BASF Pharma Callanish Limited
    Inventors: Adam Kelliher, Angus Morrison, Anil Oroskar, Rakesh Vikraman Nair Rema, Abhilesh Agarwal
  • Patent number: 9180387
    Abstract: The invention concerns a method for separating fractions of a mixture to be separated, in a device (1) comprising: several chromatography columns (21, 22, 23,) mounted in series; an open separation loop comprising in input a point for injecting (6) eluent in one of the columns and in output a point for drawing (8) a fraction of the mixture. The method includes the following steps: batch injection of the mixture to be separated in the open separation loop (4); collecting at least two fractions; offsetting at least one column of the eluent injecting and fraction drawing points (6, 8) of the separation loop (4). The invention also concerns a device for separating fractions of a mixture to be separated.
    Type: Grant
    Filed: July 25, 2006
    Date of Patent: November 10, 2015
    Assignee: NOVASEP PROCESS
    Inventors: Eric Valery, Olivier Ludemann-Hombourger
  • Patent number: 9005990
    Abstract: The present invention concerns a method of purifying colistin using reverse phase chromatography, wherein loading a column with colistin base in acetic acid and high ethanol concentration and eluting with low ethanol concentration is performed.
    Type: Grant
    Filed: September 29, 2010
    Date of Patent: April 14, 2015
    Assignee: Xellia Pharmaceuticals APS
    Inventors: Torben Koch, Carsten Overblle Petersen
  • Patent number: 8999172
    Abstract: A system is provided for removal of undesirable dissolved substances from solutions containing two or more dissolved substances to produce one or more new solutions suitable for beneficial use. The system utilizes amphoteric media in a treatment cycle where dissolved substances from the concentrated solution are first adsorbed by the media and subsequently rinsed with water to desorb and collect the dissolved substances sequentially into dilute effluent streams the substances are either aggregated or segregated based upon differences in relative concentrations of dissolved substances that is a result of differences in the affinity of the media for the dissolved substances. One or more of the dilute effluent streams are treated with a desalination process to recover water for media rinse and to concentrate the separated dissolved substances to facilitate beneficial use or disposal.
    Type: Grant
    Filed: December 13, 2011
    Date of Patent: April 7, 2015
    Assignee: Global Water Advisors, Inc.
    Inventor: Joseph E. Zuback
  • Patent number: 8992778
    Abstract: Embodiments of the present invention feature methods and apparatus for performing chromatographic separations. The invention feature methods and control means in the form of computer programs and software that control the formation of a concentration gradient at two or more total flow rates, with an elution period occurring in a slow flow rate and at least other portions of the gradient occurring during a fast total flow rate.
    Type: Grant
    Filed: February 5, 2007
    Date of Patent: March 31, 2015
    Assignee: Waters Technologies Corporation
    Inventor: Hongji Liu
  • Patent number: 8956535
    Abstract: A single pass simulated moving bed apparatus and methods are described for continuously separating a target molecule from a liquid mixture, using a simulated moving bed system. The simulated moving bed system includes a plurality of filter cartridge modules in serial fluid communication. Each filter cartridge module includes a volume of stationary phase particulates adjacent a porous substrate layer. The volume of stationary phase particulates has a bed height of less than 1 centimeter.
    Type: Grant
    Filed: July 11, 2008
    Date of Patent: February 17, 2015
    Assignee: 3M Innovative Properties Company
    Inventors: Kelly J. Gibbens, Masayuki Nakamura, Kannan Seshadri, Andrew W. Rabins, Larry J. Carson, Robert T. Fitzsimons, Jr.
  • Publication number: 20140284279
    Abstract: The present invention provides an apparatus that can be used to connect a flash chromatography instrument to a fraction collector and a mass detector to perform mass-directed flash chromatography.
    Type: Application
    Filed: March 24, 2014
    Publication date: September 25, 2014
    Applicant: BIOTAGE AB
    Inventors: Anders WARNGREN, Anders WESSMAN, Erik HALLIN, Lars JOHNSSON
  • Publication number: 20140251913
    Abstract: A chromatography system for separation of a biopolymer is described, comprising at least one feed tank, at least one hold tank, at least one elution buffer tank, at least one eluate tank, at least two packed bed chromatography columns and at least one pump and at least one outlet detector both fluidically connected to said each packed bed chromatography column, wherein the feed tank, the hold tank(s), the elution buffer tank and the eluate tank are each fluidically connected to the packed bed chromatography columns via a system of valves.
    Type: Application
    Filed: May 19, 2014
    Publication date: September 11, 2014
    Applicant: GE HEALTHCARE BIO-SCIENCES AB
    Inventors: KAROL LACKI, MARTIN HALL
  • Patent number: 8821732
    Abstract: A device (SMB) for separation by simulated moving bed adsorption comprises a plurality of elementary zones Zi in series operating in a closed loop, each of said zones comprising, between two successive fluid injection or extraction points, a unique bed Li of adsorbant solid with volume VAi and a non-selective free volume Vi, in which the majority of the zones are ordinary elementary zones each having an identical volume VA of the same adsorbant S, and a substantially identical non-selective free volume equal to V; the device also comprises at least one particular elementary zone Z0, termed the particular elementary zone, comprising a non-selective free volume V0 which is greater than V, and a unique bed L0 of adsorbant S0 with volume VA0 which is less than VA, S0 having a volume adsorption capacity C0 which is greater than that, C, of S, such that the overall adsorption capacity C0×VA0 of Z0 is closer to the overall adsorption capacity C×VA of each of the ordinary elementary zones than the overall adsorption
    Type: Grant
    Filed: December 1, 2008
    Date of Patent: September 2, 2014
    Assignee: IFP Energies Nouvelles
    Inventors: Philibert Leflaive, Tom Frising, Damien Leinekugel-Le-cocq, Gerard Hotier
  • Patent number: 8802913
    Abstract: A process for separating a product from a multicomponent feedstream to an adsorption apparatus or system is described. The apparatus or system may comprise a moving-bed or a simulated moving-bed adsorption means. The product comprises at least one organic compound, such as an aryl compound with alkyl substitutes. In embodiments the conduits used to supply the feedstream to the apparatus or system are flushed with media of multiple grades. The improvement is a more efficient use of the desorbent. In embodiments the process achieves improvements in one or more of efficiency of adsorption separation, capacity of adsorption apparatus systems, and purity of product attainable by adsorption process.
    Type: Grant
    Filed: October 3, 2013
    Date of Patent: August 12, 2014
    Assignee: ExxonMobil Chemical Patents Inc.
    Inventor: John R. Porter
  • Patent number: 8741134
    Abstract: In a preferred embodiment, a sample container storage part for storing a number of sample containers S, a nozzle for dropping a sample component separated and supplied by an LC and an additive liquid such as digestive fluid supplied from another liquid supplying part to the sample container S, a carrying mechanism for carrying and positioning the sample container at an arbitrary position under the nozzle, and a second nozzle, serving as a suction/injection mechanism, for sucking in the fractionated/collected sample component and injecting the sample component to another LC. The carrying mechanism provides a rotation mechanism. The carrying mechanism rotates over 180 degrees and carries the sample container S completed with fractionating/collecting to the position of the second nozzle, and the sample is sucked in by the second nozzle and injected to the LC of next stage.
    Type: Grant
    Filed: December 20, 2005
    Date of Patent: June 3, 2014
    Assignee: Shimadzu Corporation
    Inventors: Shuzo Maruyama, Yosuke Iwata
  • Patent number: 8741146
    Abstract: A method for the recovery of acids and other materials from hydrometallurgic process solutions comprising processing said solutions utilizing a simulated moving bed chromatographic method to produce at least two product streams.
    Type: Grant
    Filed: February 28, 2012
    Date of Patent: June 3, 2014
    Assignee: Amalgamated Research LLC
    Inventors: Michael M. Kearney, Michael W. Mumm, Lawrence Velasquez, William Jacob, IV
  • Patent number: 8722955
    Abstract: A device (SMB) for separation by simulated moving bed adsorption comprises a plurality of elementary adsorption zones Zi in series operating in a closed loop, and at least one singular adsorption zone with a dead volume which is greater than the adsorption zones Zi, the solid adsorbant of said singular adsorption zone having a granulometry which is lower than that of the solid adsorbant of the ordinary adsorption zones.
    Type: Grant
    Filed: March 24, 2009
    Date of Patent: May 13, 2014
    Assignee: IFP Energies Nouvelles
    Inventors: Gerard Hotier, Tom Frising, Philibert Leflaive, Damien Leinekugel le Coco
  • Patent number: 8679332
    Abstract: A method and apparatus for monitoring and controlling the nano-scale flow rate of fluid in the operating flow path of a HPLC system without relying on a nano-scale sensor in the operating flow path. A main flow sensor is disposed in the main flow path between the pump and a flow-divider. A waste flow sensor is disposed in the waste flow path downstream of the splitter. The output signal of the waste flow sensor is subtracted from the output signal of the main flow sensor in a difference circuit. The difference signal is divided by the output signal from the main flow sensor in a divider circuit. The output of the divider circuit represents an empirical split ratio of the flow-divider and is independent of media composition.
    Type: Grant
    Filed: December 19, 2007
    Date of Patent: March 25, 2014
    Assignee: Waters Technology Corporation
    Inventors: Geoff C. Gerhardt, Keith Fadgen
  • Patent number: 8679333
    Abstract: A method and apparatus for monitoring and controlling nano-scale flow rate of fluid in the operating flow path of a HPLC system provide fluid flow without relying on complex calibration routines to compensate for solvent composition gradients typically used in HPLC. The apparatus and method are used to correct the flow output of a typical, analytical-scale (0.1-5 mL/min) HPLC pump to enable accurate and precise flow delivery at capillary (<0.1 mL/min) and nano-scale (<1 ?L/min) HPLC flow rates.
    Type: Grant
    Filed: January 25, 2010
    Date of Patent: March 25, 2014
    Assignee: Waters Technologies Corporation
    Inventors: Geoff C. Gerhardt, Joseph A. Luongo
  • Publication number: 20140061133
    Abstract: A method for chromatographically separating analytes of a liquid sample comprises: (i) providing the sample in a conduit; (ii) providing a solvent for the sample; (iii) causing the solvent to simultaneously flow into the conduit so as to expel the sample from the conduit and flow into and through a second conduit so as to exit said second conduit; (iv) simultaneously providing the expelled sample and the exited solvent to a mixing tee-junction such that the expelled sample and the exited solvent mix thereat; (v) providing the mixture of the expelled sample and the exited solvent to a chromatographic column such that the analytes are transferred to the column and are chromatographically separated therein under the influence of a flow of the solvent, or a different solvent or a mixture of solvents.
    Type: Application
    Filed: August 31, 2012
    Publication date: March 6, 2014
    Inventor: Joseph Lewis HERMAN
  • Patent number: 8658040
    Abstract: The invention relates to a chromatographic process for substance separation in the context of the preparation of chemicals such as, for example, chiral pharmaceuticals, isomers or biomolecules on the small-scale and production scale, based on Simulated Moving Bed (SMB=countercurrent chromatography) technology.
    Type: Grant
    Filed: August 12, 2009
    Date of Patent: February 25, 2014
    Assignee: Bayer Intellectual Property GmbH
    Inventors: Jochen Strube, Karsten-Ulrich Klatt, Gerhard Noeth, Joern Greifenberg, Sebastian Bocker, Heinz Kansy, Peter Jahn, Berthold Justen
  • Patent number: 8621915
    Abstract: The invention provides improved methods and apparatus for multidimensional analysis, especially for multidimensional liquid chromatography. Methods and apparatus for the quantitative determination of one or more components comprised in a sample mixture are described. Methods and apparatus of the invention typically allow accurate quantitative determination of more components of the mixture than prior multidimensional methods. The invention is particularly useful for, but is not limited to the analysis of complex mixtures of peptides and proteins.
    Type: Grant
    Filed: May 27, 2008
    Date of Patent: January 7, 2014
    Assignee: Waters Technologies Corp.
    Inventor: Hongji Liu
  • Patent number: 8608960
    Abstract: Provided are methods of separating an immunoreactive compound from at least one immaterial component, using a simulated moving bed (“SMB”) system and a SMB apparatus for use in these methods. Also provided are purified immunoreactive compounds prepared using the SMB methods and apparatus and methods of treatment with the purified immunoreactive compounds.
    Type: Grant
    Filed: May 21, 2007
    Date of Patent: December 17, 2013
    Assignee: Biogen Idec Inc.
    Inventors: Jorg Thommes, Alan M. Sonnenfeld, John P. Pieracci, Lynn Conley, Marc Bisschops, Maarten Pennings
  • Publication number: 20130319945
    Abstract: A device for field flux fractioning comprises a sensor to determine the presence of particles in a liquid and a channel impermeable for particles and permeable for liquid. A pump conveys the liquid to first and second paths to the channel, where the second path connects in a first position to the pump outlet and in a second position to the sensor. An injection device injects a sample comprising particles into the liquid flowing through the first path. A distribution device distributes the flow volume conveyed by the pump in a first position at a predetermined ratio to the first and second paths. A control device comprises a valve and a measuring device to measure the flow volume. The valve controls the flow volume in the first path in consideration of the measuring device measurement and the pump conveys the liquid in a flow volume, which can be precisely dosed.
    Type: Application
    Filed: September 22, 2011
    Publication date: December 5, 2013
    Applicant: WYATT TECHNOLOGY EUROPE GMBH
    Inventors: Ulrich Rosch, Christoph Johann
  • Patent number: 8586350
    Abstract: A high-purity fragment is obtained by a simple mechanism and method for separating and purifying a nucleic acid, particularly fragment DNA, extremely efficiently and with a high reproducibility, wherein elution with a high-concentration salt is not performed and necessity of elution and purification is eliminated. This mechanism is a mechanism for purifying a nucleic acid, particularly fragment DNA using a monolith structure formed with glass or silica, specifically, an integral porous body having an open structure with pores that communicate the upper end with the lower end, wherein through-pores corresponding to nucleic acid sizes of 35 bp (mer) to 100 Kbp (mer) are provided.
    Type: Grant
    Filed: February 12, 2004
    Date of Patent: November 19, 2013
    Assignee: GL Sciences Incorporated
    Inventors: Osuman Toujou, Masayoshi Ohira, Kensuke Okusa, Nobuo Seto, Masahiro Furuno
  • Publication number: 20130248451
    Abstract: A chromatography system for separation of a biopolymer is described, comprising at least one feed tank, at least one hold tank, at least one elution buffer tank, at least one eluate tank, at least two packed bed chromatography columns and for each packed bed chromatography column at least one pump and at least one outlet detector both connected to said each packed bed chromatography column, wherein the feed tank, the hold tank(s), the elution buffer tank and the eluate tank are each connected to the packed bed chromatography columns via a system of valves.
    Type: Application
    Filed: December 2, 2011
    Publication date: September 26, 2013
    Applicant: GE HEALTHCARE BIO-SCIENCES AB
    Inventors: Martin Hall, Karol Lacki
  • Patent number: 8529757
    Abstract: A process for separating a product from a multicomponent feedstream to an adsorption apparatus or system. The apparatus or system may comprise a moving-bed or a simulated moving-bed adsorption means. The product comprises at least one organic compound, such as an aryl compound with alkyl substitutes. In embodiments the conduits used to supply the feedstream to the apparatus or system are flushed with media of multiple grades. In embodiments the process achieves improvements in one or more of efficiency of adsorption separation, capacity of adsorption apparatus systems, and purity of product attainable by adsorption process.
    Type: Grant
    Filed: May 5, 2010
    Date of Patent: September 10, 2013
    Assignee: ExxonMobil Chemical Patents Inc.
    Inventors: Anthony Go, Dana Lynn Pilliod, John R. Porter
  • Patent number: 8496836
    Abstract: A process for continuous or quasi-continuous purification of a multi-component mixture (F) by means of individual chromatographic columns through which the mixture is fed by means of at least one solvent(s). The multi-component mixture (F) at least comprises light impurities (A), an intermediate product (B) to be purified and heavy impurities (C), and the columns are grouped into at least four sections (?,?,?,?). After or within a switch time (t*) the last column from the first section (?) is moved to the first position of the second section (?), the last column of the second section (?) is moved to the first position of the third section (?), the last column of the third section (?) is moved to the first position of the fourth section (?) and the last column of the fourth section (?) is moved to become the first column of the first section (?).
    Type: Grant
    Filed: October 29, 2010
    Date of Patent: July 30, 2013
    Assignee: Eidgenossische Technische Hochschule Zurich
    Inventors: Lars Aumann, Massimo Morbidelli
  • Patent number: 8465649
    Abstract: A process is disclosed for separating biomolecules from an aqueous solution containing the biomolectules and impurities, having different affinities and/or interactions with a solid support. The solution is passed over a fixed bed of chromatographic resin containing at least three zones, with flow of liquid being arranged between adjacent zones and between a last and first zone. Each of several sequences includes at least an adsorption stage, a rinsing stage, or a desorption stage, with each subsequent sequence being carried out by a downstream displacement of fronts in the zones by approximately the same increment before the periodical displacement of the introduction and withdrawal points.
    Type: Grant
    Filed: April 17, 2012
    Date of Patent: June 18, 2013
    Assignee: Groupe Novasep
    Inventors: Marc-André Theoleyre, Stanislas Baudouin, Annick Merrien, Eric Valery, Olivier Ludemann-Hombourger, David Laurent, Margit Holzer
  • Patent number: 8440086
    Abstract: A process for continuous or quasi-continuous purification of a multi-component mixture by means of at least four individual chromatographic columns through which the mixture is fed by means of at least one solvent, is given, wherein the multi-component mixture is to be separated into an integer number n of fractions, wherein n is at least 5.
    Type: Grant
    Filed: December 16, 2009
    Date of Patent: May 14, 2013
    Assignee: ChromaCon AG
    Inventors: Thomas Müller-Späth, Lars Aumann
  • Patent number: 8436297
    Abstract: In accordance with an embodiment of the invention, there is provided a method for reducing or eliminating matrix interfering components in a biopharmaceutical product in a liquid chromatography-mass spectrometry system. The method comprises diverting to waste the entire flow of an eluant emerging from liquid chromatography of a sample, for a time period to remove contaminants that cause matrix interference to a degree sufficient to allow a desired accuracy in detection of an extractable; and, after the time period, directing the entire flow of the eluant to a mass spectrometer to detect the presence of the extractable.
    Type: Grant
    Filed: August 22, 2008
    Date of Patent: May 7, 2013
    Assignee: EMD Millipore Corporation
    Inventors: Tongbo Jiang, Cheryl Follo, Maurice G. Phelan
  • Patent number: 8397553
    Abstract: A flow controller for use with a liquid chromatography detector. The flow controller includes a flow channel comprising an inlet portion, a control channel portion in communication with the inlet portion, and an outlet portion in communication with said control channel portion. The control channel portion has a cross-sectional area smaller than a cross-sectional area of a drift tube of the liquid chromatography detector for channeling the flow of droplets through the smaller cross-sectional area. The flow controller is shaped and sized to reduce pressure fluctuations and turbulence in the droplet stream of the liquid chromatography detector.
    Type: Grant
    Filed: December 6, 2007
    Date of Patent: March 19, 2013
    Assignees: The Curators of the University of Missouri, W.R. Grace & Co.-Conn
    Inventors: Zhi Xu, Rakesh Bose, James M. Anderson
  • Patent number: 8372287
    Abstract: A solid-phase extraction device utilizing a section of expanded polytetrafluoroethylene (ePTFE) tubing as the stationary phase is disclosed. The microscopic pores of ePTFE tubing are impregnated with a binding agent having an affinity for a target constituent within a matrix. The matrix is prepared and loaded onto the stationary phase of the system. The target constituent is retained by the stationary phase. The constituent is stripped from the stationary phase with a stripping solution, and collected for further analysis or use.
    Type: Grant
    Filed: September 2, 2008
    Date of Patent: February 12, 2013
    Assignee: ALS Group USA, Corp
    Inventors: Stephen M. Workman, Robert T. Shannon
  • Patent number: 8357302
    Abstract: Product yields in chemical reactions that produce a solid product from a liquid reaction mixture are improved by chromatographically separating certain key impurities from the product mixture prior to crystallization, or from the filtrate after crystallization in which case further product is crystallized from the filtrate. The removal of key impurities either before the first crystallization or between the first and second crystallizations facilitates the crystallization of product to produce a higher yield of product.
    Type: Grant
    Filed: July 26, 2011
    Date of Patent: January 22, 2013
    Assignee: Ampac Fine Chemicals LLC
    Inventors: Olivier Dapremont, Aslam Malik
  • Patent number: 8349175
    Abstract: The apparatus of the present invention relates to rotary valves which provide simultaneous interconnection of a plurality of asymmetrically disposed stationary adsorption chambers in fluid communication with an upper stator of the rotary valve having a lower rotor which upon indexing in accordance with a predetermined periodic sequence provides a simulating bed moving process. Further, the apparatus relates to such combinations of adsorbent chambers and rotary valves in a manner which is useful for implementing a simulating moving bed process wherein the continuous contacting of fluids and solids occurs in order to affect a separation or a purification process in a substantially plot area than previous SMB systems using turntable arrangements of adsorbent chambers.
    Type: Grant
    Filed: March 23, 2012
    Date of Patent: January 8, 2013
    Assignee: Orochem Technologies, Inc.
    Inventor: Anil R. Oroskar
  • Patent number: 8282831
    Abstract: A method for the chromatographic separation of components of a multicomponent fluid mix by means of the simulated moving bed method wherein the multicomponent fluid mix and at least one solvent are fed to inflows of a plurality of chambers containing at least one solid substance and connected to each other in series to form a closed loop. An extract stream containing at least one first component separated from the multicomponent fluid mix as well as a raffinate stream containing at least one second component separated from the multicomponent fluid mix are carried out of the chambers through a first and second outflows. At least part of the raffinate stream and/or extract stream carried off at the first and/or second outflows is preliminarily stored and recirculated to the first and/or second inflow of the chambers alternately or simultaneously with the multicomponent fluid mix and/or the solvent within one clock unit.
    Type: Grant
    Filed: April 16, 2008
    Date of Patent: October 9, 2012
    Assignee: Max-Planck-Gesellschaft zur Foderung der Wissenchaften e. V.
    Inventors: Lars Kessler, Andreas Seidel-Morgenstern
  • Patent number: 8241492
    Abstract: Disclosed herein is a simulated moving bed chromatography device comprises a minimum of one stationary pipe with a plurality of inlet/outlet channels, a rotary device next to the stationary pipes, a stationary radial flow segmented vessel communicates with the rotary device, a fluid moving device and a drive means to rotate the rotary device. The counter movement of the stationary phase and the fluid is simulated by rotating the rotary device in the same direction as the circulating fluid flow, and the fluid flows through the flow distribution segments, the stationary phase segments, the outer fluid transfer segments, holes or by passes of the improved partition plates in the flow distribution segments/compartments and outer fluid transfer segments.
    Type: Grant
    Filed: December 20, 2011
    Date of Patent: August 14, 2012
    Inventor: Leon Yuan
  • Patent number: 8236179
    Abstract: A chromatography or supercritical extraction method is disclosed, in which the eluent comprises a mixture of a fluid and a modifier and in which the fluid is recycled. One exemplary method comprises an operation consisting in determining at least one quantity linked to the level of modifier that is mixed with the recycled fluid and, if necessary, a correction operation in order to limit variations in the level of modifier in the eluent at the inlet of the column or the extractor. The disclosure also relates to a chromatography or extraction installation.
    Type: Grant
    Filed: November 11, 2011
    Date of Patent: August 7, 2012
    Assignee: PIC Solution
    Inventor: Mohamed Shaimi
  • Patent number: 8216475
    Abstract: The invention concerns a method for separating fractions of a mixture using a chromatography device. The method includes the following steps: controlling in one node of the device, the history of a specific variable of the fractions of the mixture to be separated; detecting one characteristic point of the history, the characteristic point being between two successive steps of fraction collecting; comparing the position of the characteristic point relative to a target position; adjusting the amount of mobile phase modifying the position of the characteristic point to cause the position of the characteristic point to coincide with the target position. The invention also concerns a device for implementing the method. The method enables the operation of the device to be automatically set.
    Type: Grant
    Filed: March 7, 2007
    Date of Patent: July 10, 2012
    Assignee: Novasep
    Inventors: Eric Valery, Céline Morey
  • Patent number: 8211312
    Abstract: One exemplary embodiment can be a separation system. The separation system can include an adsorption zone, a rotary valve, a transition zone, and one or more pipes. Usually, the transition zone includes one or more lines communicating the rotary valve with the adsorption zone. The rotary valve alternatively may distribute an input of a feed or a desorbent to the adsorption zone or alternatively can receive an output of a raffinate or an extract from the adsorption zone in a line, and a remnant may remain in the line from a previous input or output. One or more pipes outside the transition zone communicating with the rotary valve can form at least one pipe volume receiving an input for dislodging a remnant or for receiving a remnant from the line. The remnant may be different from the input or output.
    Type: Grant
    Filed: March 27, 2009
    Date of Patent: July 3, 2012
    Assignee: UOP LLC
    Inventors: Douglas George Stewart, Grace Chao, Braden E. Smith, Stephen W. Sohn, Robert J. L. Noe
  • Patent number: 8192629
    Abstract: The present invention relates to a chromatographic separation process for fractionating betaine-containing solutions by utilizing fractions comprising parts of the separation profile as a substituent of the eluent in a novel and inventive manner. The process provides improved separation capacity and separation efficiency without affecting the yield or purity of betaine or other products. The process can especially be applied to sequential SMB separation systems.
    Type: Grant
    Filed: February 24, 2010
    Date of Patent: June 5, 2012
    Assignee: Danisco A/S
    Inventors: Jyrki Airaksinen, Heikki Heikkilä, Jari Lewandowski, Kari Laiho
  • Patent number: 8182696
    Abstract: A process is disclosed for separating biomolecules from an aqueous solution containing the biomolectules and impurities, having different affinities and/or interactions with a solid support. The solution is passed over a fixed bed of chromatographic resin containing at least three zones, with flow of liquid being arranged between adjacent zones and between a last and first zone. Each of several sequences includes at least an adsorption stage, a rinsing stage, or a desorption stage, with each subsequent sequence being carried out by a downstream displacement of fronts in the zones by approximately the same increment before the periodical displacement of the introduction and withdrawal points.
    Type: Grant
    Filed: June 18, 2007
    Date of Patent: May 22, 2012
    Assignee: Groupe Novasep
    Inventors: Marc-André Theoleyre, Stanislas Baudouin, Annick Merrien, Eric Valery, Olivier Ludemann-Hombourger, David Laurent, Margit Holzer
  • Patent number: 8177980
    Abstract: The present invention provides methods of separating at butanediol compound from a mixture containing polyhydric alcohols and butanediol compounds. The mixture of polyhydric alcohols typically contains propylene glycol and ethylene glycol in addition to the butanediol contaminants. Butanediol contaminants are removed by contacting the mixture with a chromatographic matrix. Either the butanediol compounds or the non-butanediol compounds adsorb to the chromatographic matrix. If desired, the adsorbed compounds may be eluted from the matrix, purified and used in products.
    Type: Grant
    Filed: September 22, 2008
    Date of Patent: May 15, 2012
    Assignee: Archer Daniels Midland Company
    Inventors: Ahmad K. Hilaly, Robert Duane Sandage, John G. Soper
  • Patent number: 8158004
    Abstract: Provided is a method of manufacturing target substances with use of supercritical fluid chromatography, by which the following are achieved: solution of a problem at the time of sequential injections of samples containing the target substances; an increase of a treatment amount of separation per unit time; and improvement of efficiency in separation. The method includes the steps of: injecting the sample containing the target substances into a mobile phase; and returning composition of the mobile phase to a pre-change state after changing the composition of the mobile phase. The step of returning the composition of the mobile phase to the pre-change state after changing the composition of the mobile phase is performed during a period of time from detection of a peak of one of the target substances which is eluted latest from a column among the target substances separated by the supercritical fluid chromatography apparatus to injection of the next sample, whereby the problem is solved.
    Type: Grant
    Filed: October 22, 2009
    Date of Patent: April 17, 2012
    Assignee: Daicel Chemical Industries, Ltd.
    Inventors: Kenichiro Miyazawa, Takeshi Ishiguro
  • Patent number: 8123950
    Abstract: A process for separating a feed F by simulated moving bed adsorption in a SMB device is described, the device comprising external bypass lines Li/i+1 which directly connect two successive plates Pi, Pi+1, the index i being either even or (exclusive of the foregoing) odd, along the whole length of the column, in order to flush said plates, in which each of the bypass lines Li/i+1 comprises automated means for regulating the flow rate in the bypass lines, the degree of opening of said regulating means being defined by the following three rules: a) establishing a flow rate corresponding to an oversynchronicity in the range 15% to 30% in all of the open bypass lines of zone 1; b) establishing a flow rate corresponding to the synchronicity to within plus or minus 8% in all of the open bypass lines of zones 2 and 3; c) establishing a flow rate corresponding to an oversynchronicity in the range 20% to 40% in all of the open bypass lines of zone 4.
    Type: Grant
    Filed: April 9, 2010
    Date of Patent: February 28, 2012
    Assignee: IFP Energies Nouvelles
    Inventors: Xavier Decoodt, Gerard Hotier, Philibert LeFlaive, Damien Leinekugel Le Cocq
  • Patent number: 8123952
    Abstract: A process for separating a feed F by simulated moving bed adsorption in a SMB device comprises at least one zone 1 for desorption of the compounds produced in the extract, a zone 2 for desorption of the compounds produced in the raffinate, a zone 3 for adsorption of the compounds produced in the extract, a zone 4 located between the raffinate withdrawal and the desorbant supply, the device comprising external by-pass lines Li/i+1 directly connecting two successive plates Pi and Pi+1; in which the degree of opening of means for restricting the flushing flow rate of the by-pass lines Li/i+1 are sequentially modified such that: 1) in an operational zone where there is at least one closed by-pass line, a super-synchronicity of the flushing flow rate is established in all of the by-pass lines which are not closed belonging to the zone under consideration, said super-synchronicity being defined by the following formula: S=a+b(nf/nt) in which the constant a is a constant in the range ?5 to 5 and b is a constant
    Type: Grant
    Filed: July 29, 2009
    Date of Patent: February 28, 2012
    Assignee: IFP Energies Nouvelles
    Inventors: Xavier Decoodt, Gerard Hotier, Philibert Leflaive, Damien Leinekugel Le Cocq
  • Patent number: 8123951
    Abstract: A process for separating a feed F by simulated moving bed adsorption in a SMB device comprises external bypass lines Li/i+1 which directly connect two successive plates, Pi, Pi+1, the index “i” being either even or (exclusive of the foregoing) odd, along the whole length of the column, allowing said plates to be flushed, in which each of the bypass lines Li/i+1 comprises automated means for regulating the flow rate in the bypass lines, the bypass lines in certain cases being subject to a flushing flow during injection or withdrawal operations.
    Type: Grant
    Filed: February 11, 2011
    Date of Patent: February 28, 2012
    Assignee: IFP Energies Nouvelles
    Inventors: Gerard Hotier, Damien Leinekugel Le Cocq
  • Patent number: 8114281
    Abstract: A fraction collector comprising a movable tray is provided. The movable tray may be attached to the fraction collector support system in a variety of ways and adjusted without adjusting the parts of the fraction collector support system. The moveable tray may be stably attached to the fraction collector support system by either fixed or removable pegs, as well as by channels. In an exemplary embodiment, a mechanized lift is used to adjust the position of the movable tray.
    Type: Grant
    Filed: March 25, 2008
    Date of Patent: February 14, 2012
    Assignee: Gilson, Inc.
    Inventors: Lucas D. Roenneburg, Jeffrey L. Acker
  • Patent number: 8114282
    Abstract: A chromatography or supercritical extraction method is disclosed, in which the eluent comprises a mixture of a fluid and a modifier and in which the fluid is recycled. One exemplary method comprises an operation consisting in determining at least one quantity linked to the level of modifier that is mixed with the recycled fluid and, if necessary, a correction operation in order to limit variations in the level of modifier in the eluent at the inlet of the column or the extractor. The disclosure also relates to a chromatography or extraction installation.
    Type: Grant
    Filed: August 11, 2006
    Date of Patent: February 14, 2012
    Assignee: PIC Solutions
    Inventor: Mohamed Shaimi
  • Patent number: 8110113
    Abstract: The present invention provides a method for determining a level of a RuBP, PGA, 2-PA in a photosynthetic cellular extract by resolving at least one RuBP, PGA, or 2-PA or combinations thereof in a photosynthetic cellular extract obtained from a plant. In another aspect, it provides for detecting at least one resolved RuBP, PGA, or 2-PA or combinations, thereby determining a level of the resolved RuBP, PGA, or 2-PA or combinations. In one aspect the photosynthetic cellular extract is obtained from a plant subjected to an abiotic stress. A method of the invention can be useful, for example, for identifying plants with increased photosynthetic performance. Also included herein is a high throughput system for identifying a plant with increased photosynthetic performance.
    Type: Grant
    Filed: April 28, 2008
    Date of Patent: February 7, 2012
    Assignee: Pioneer Hi-Bred International, Inc.
    Inventors: Itzhak Kurek, Xuehua Hu, Genhai Zhu, Lu Liu
  • Patent number: 8101422
    Abstract: An ion chromatography apparatus comprising: (a) a first chromatography column, (b) a second chromatography column, the volume of the second column being no greater than 0.9 times the volume of the first; and (c) valving disposed between said first and second columns permitting selective transfer of separated ionic species from first chamber to second chamber for further analysis.
    Type: Grant
    Filed: September 16, 2005
    Date of Patent: January 24, 2012
    Assignee: Dionex Corporation
    Inventors: Kannan Srinivasan, Rong Lin