Chromatography Patents (Class 210/656)
  • Patent number: 10596254
    Abstract: Highly effective vaccine compositions are constructed according to the methods of this invention. The methods are amenable to use with any peptidic antigen sequence and involve covalent attachment of an immunostimulatory nucleotide sequence to an antigenic peptide sequence. Preferred antigenic peptides are fusion peptides made up of one or more CTL epitope peptides in sequence fused to a T helper peptide.
    Type: Grant
    Filed: April 26, 2018
    Date of Patent: March 24, 2020
    Assignee: City of Hope
    Inventor: Don J. Diamond
  • Patent number: 10585076
    Abstract: A gas-liquid separator according to an embodiment of the present invention separates a mobile phase containing a gas and a liquid into a gas and a liquid. The gas-liquid separator according to the embodiment of the present invention includes an introduction flow channel to which a mobile phase is introduced, and a plurality of discharge flow channels connected to the introduction flow channel. A gas and a liquid are discharged from a discharge port of the discharge flow channel.
    Type: Grant
    Filed: September 17, 2014
    Date of Patent: March 10, 2020
    Assignee: SHIMADZU CORPORATION
    Inventors: Hiroomi Goto, Risa Kajiyama, Takahiro Mori
  • Patent number: 10525376
    Abstract: The present invention is directed to affinity chromatography devices that separate a targeted protein or antibody from an aqueous mixture containing the targeted protein or antibody. The chromatography device may contain a stacked membrane assembly or a wound membrane assembly. The membrane assemblies include at least one polymer membrane that contains therein inorganic particles. The polymer membrane and/or the inorganic particles have an affinity ligand bonded thereto. The affinity ligand may be a protein, an antibody, or a polysaccharide that reversibly binds to the targeted protein or antibody. The chromatography device may be repeatedly used and may be cleaned with a caustic solution between uses. The chromatography devices may have a dynamic binding capacity (DBC) of at least 30 mg/ml (or 0.07 micromol/ml) at 10% breakthrough at a residence time of 20 seconds or less.
    Type: Grant
    Filed: April 8, 2016
    Date of Patent: January 7, 2020
    Assignee: W. L. Gore & Associates, Inc.
    Inventor: Michael C. McManaway
  • Patent number: 10526367
    Abstract: The present invention is directed to affinity chromatography devices that separate a targeted protein or antibody from an aqueous mixture containing the targeted protein or antibody. The chromatography device may contain a stacked membrane assembly or a wound membrane assembly. The membrane assemblies include (1) at least one polymer membrane that contains therein inorganic particles and (2) at least one impermeable layer (e.g., a thermoplastic polymer in a solid state). The polymer membrane and/or the inorganic particles have an affinity ligand bonded thereto. The affinity ligand may be a protein, an antibody, or a polysaccharide that reversibly binds to the targeted protein or antibody. The chromatography device may be repeatedly used and may be cleaned with a caustic solution between uses. The chromatography devices has a dynamic binding capacity (DBC) of at least 30 mg/ml (or 0.07 micromol/ml) at 10% breakthrough at a residence time of 20 seconds or less.
    Type: Grant
    Filed: January 19, 2017
    Date of Patent: January 7, 2020
    Assignee: W. L. Gore & Associates, Inc.
    Inventors: Michael C. McManaway, Brian J. Swetlin, Kenneth S. Zukor
  • Patent number: 10520479
    Abstract: In a liquid chromatograph mass spectrometer (LC/MS) for performing mass spectrometry of fractionated samples prepared with a multi-dimensional LC or similar LC with high separatory capability, fractionated sample useful information which shows the degree of usefulness of various substances with respect to retention time is prepared from prior information which includes, for example, elution characteristics in the LC depending on the kind of column or other factors or the degree of ease of ionization in the MS. During a measurement, the preparative separation of an eluate and the preparation of fractionated samples are not performed within a period of time which has been judged to be useless based on the fractionated sample useful information. By selecting fractionated samples at each dimension of the multi-dimensional LC, the number of fractionated samples to be eventually subjected to mass spectrometry can be significantly reduced.
    Type: Grant
    Filed: September 8, 2014
    Date of Patent: December 31, 2019
    Assignee: SHIMADZU CORPORATION
    Inventors: Shinichi Utsunomiya, Yusaku Hioki, Yuki Ohta
  • Patent number: 10501862
    Abstract: A plating system comprising a plating tank for applying plate processing to a substrate, a sensor configured to measure actual plating film thickness of the substrate, and a controller configured to control plating current supplied to the plating tank and plating time for the plate processing of the substrate within the plating tank. The controller is capable of setting target plating film thickness, plating current, and plating time as a plate processing recipe. At least one of the plating current and the plating time is automatically corrected so that the actual plating film thickness and the target plating film thickness become equal to each other, and the result is reflected in the plate processing for the subsequent substrate.
    Type: Grant
    Filed: August 4, 2017
    Date of Patent: December 10, 2019
    Assignee: EBARA CORPORATION
    Inventors: Takashi Mitsuya, Ryuya Koizumi, Toshio Yokoyama, Masashi Shimoyama, Kunio Oishi
  • Patent number: 10494449
    Abstract: Polydisperse and charged polysaccharides are fractionated into low polydispersity fractions (preferably having pd<1.1), each containing species within a narrow range of molecular weights. An aqueous solution of the polydisperse polysaccharides is contacted with an ion exchange resin in a column and the polysaccharides are subjected to selective elution by aqueous elution buffer. The selective elution consists of at least 3 sequential elution buffers having different and constant ionic strength and/or pH and in which the subsequent buffers have ionic strength and/or pH than those of the preceding step. The new preparations are particularly suitable for the production of PSA-derivatised therapeutic agents intended for use in humans and animals.
    Type: Grant
    Filed: November 22, 2017
    Date of Patent: December 3, 2019
    Assignee: Lipoxen Technologies Limited
    Inventors: Sanjay Jain, Ioannis Papaioannou, Peter Laing
  • Patent number: 10486049
    Abstract: The invention relates to a device and method for monitoring a swimming performance. The device comprises one or more motion-sensitive sensors for providing motion data characteristic to the motion of the swimmer during said swimming performance and a computing unit adapted to detect body motions from said motion data using predefined criteria. According to the invention the computing unit comprises means for calculating a plurality of correlation factors depicting correlation of motion data between successive body motions detected, means for storing the correlation factors as a time series, and means for determining one or more parameters characteristic to the swimming performance based on said correlation factors stored. The invention can be used for robust determination of swimmer's turns, distance swum or swimming style, for example.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: November 26, 2019
    Assignee: Amer Sports Digital Services Oy
    Inventors: Heikki Nieminen, Markus Kemetter, Janne Kallio, Antti Virtanen
  • Patent number: 10489036
    Abstract: Systems and methods that facilitate the setup and visualization of a configurable process, for example a chromatography experiment to be conducted using a configurable chromatography system. A user interface displays category regions representing sections of a process, and displays a plurality of selectable items representing components appropriate for placement in the category regions. A user interface control causes selection of one of the selectable items and placement of the selected item into one of the category regions, to define a selected process configuration. The user interface control may be a scrolling control that causes a set of selectable items appropriate for placement in the respective category region to scroll through the category region. When the computer displaying the user interface is also connected to the system being configured, the user interface may also facilitate setup, monitoring, and control of the resulting process.
    Type: Grant
    Filed: October 14, 2015
    Date of Patent: November 26, 2019
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: Christof Schultz, Dominic Casenas, Farah Mavandadi
  • Patent number: 10481135
    Abstract: A device and method for the separation, detection, and identification of multiple individual components in a sample where the separation device is gas chromatograph or a microchip separation device. The chromatograph or microchip separation and detection device has a detector including a two dimensional or substantially two dimensional sensor material sensitive to and has a property change (such as a change in resistance) when the surface of the two dimensional or substantially two dimensional sensor material is exposed to a component of a sample in amounts as low as 10?21 grams of component.
    Type: Grant
    Filed: March 11, 2016
    Date of Patent: November 19, 2019
    Assignee: HOWARD UNIVERSITY
    Inventor: Joshua Halpern
  • Patent number: 10473574
    Abstract: There is provided an assembly and process for its preparation for predicting the permeability of chemical compounds, comprising a donor compartment for adding a composition comprising the compound; a barrier based on a support and a phospholipid layer adhering to the support; and an acceptor compartment for accepting the compound upon permeation of the barrier.
    Type: Grant
    Filed: November 17, 2015
    Date of Patent: November 12, 2019
    Assignee: Syddansk Universitet
    Inventors: Massimiliano Pio Di Cagno, Annette Bauer-Brandl
  • Patent number: 10463988
    Abstract: Methods and systems for chromatography are disclosed that employ a flexible container configured to fit within a support structure and adapted to receive a filtration or absorptive medium, such as a chromatography resin. The flexible container can include at least one inlet, at least one outlet, and a separation barrier peripherally sealed within the container to separate the container into a resin containing portion and a drainage portion. The barrier can be configured to exclude the resin material from the drainage portion during use while allowing fluids to pass therethrough. The disposable chromatography system can further include one or more agitators disposed within the flexible container and adjustably configured to be raised or lowered in the flexible container. When the agitator is in the raised position, the resin packing material can operate in a settled, packed-bed configuration.
    Type: Grant
    Filed: September 23, 2011
    Date of Patent: November 5, 2019
    Assignee: GE HEALTHCARE BIO-SCIENCES CORP.
    Inventors: John J. Vicalvi, Joseph Makowiecki, Joseph D. Crowell, Parrish M. Galliher
  • Patent number: 10413495
    Abstract: A method for forming a photosensitizer product that is resistant to absorption by living tissue that may include binding a photosensitizer compound with an oxide-containing particle to provide the photosensitizer derivative having a microscale size, and mixing the photosensitizer derivative into a lotion. The microscale size of the photosensitizer derivative obstructs absorption by cell tissue.
    Type: Grant
    Filed: November 17, 2016
    Date of Patent: September 17, 2019
    Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Scott B. King, Brandon M. Kobilka, Joseph Kuczynski, Jacob T. Porter, Jason T. Wertz
  • Patent number: 10383908
    Abstract: Methods are provided for inducing granulation tissue on third-degree burns present on the skin of a mammalian subject, which includes human subjects. A method according to the disclosure comprises contacting a third-degree burn wound with an extract of Hamelia patens, in combination with a dermatologically-acceptable carrier. Methods according to the disclosure are applicable to chemically-induced, electrically-induced, and thermally-induced third-degree burn wounds on skin.
    Type: Grant
    Filed: December 26, 2017
    Date of Patent: August 20, 2019
    Inventor: Don Wayne Berry
  • Patent number: 10344229
    Abstract: A method for determining a relationship between the ratio of solvent power to critical solvent power and the threshold light paraffin content of a hydrocarbon fluid is provided. The method comprises: dividing the plurality of hydrocarbon fluids into subgroups, based on the ratio of solvent power to critical solvent power; for each of the subgroups, determining the threshold light paraffin content, said threshold light paraffin content being the light paraffin content of the hydrocarbon fluids at the point at which the fouling tendency of the hydrocarbon fluids exceeds a fouling threshold; and determining a relationship between the ratio of solvent power to critical solvent power and the threshold light paraffin content.
    Type: Grant
    Filed: August 17, 2016
    Date of Patent: July 9, 2019
    Assignee: BP Corporation North America Inc.
    Inventors: Soban Balashanmugam, Ronald Fisher, Devin Halliday
  • Patent number: 10329454
    Abstract: The present invention relates to a composition comprising a silane modified metal oxide, wherein the silane modified metal oxide comprises a metal oxide having attached at least one silyl group, and wherein the silyl group comprises at least one —SO3?M+, —OSO3?M+, —SSO3?M+, —NHSO3?M+, —NR?SO3?M+, —NR?3+A?, or -Q+A? group. R?, which can be the same or different, is a branched or unbranched, substituted or unsubstituted alkyl, alkenyl or alkynyl group or a substituted or unsubstituted aryl, heteroaryl, alkylaryl; or arylalkyl group, M+ is a cationic counterion, and A? is a anionic counterion. The present invention further relates to the silane modified metal oxide used in the disclosed chemical mechanical polishing composition.
    Type: Grant
    Filed: June 16, 2016
    Date of Patent: June 25, 2019
    Assignee: Cabot Corporation
    Inventor: James A. Belmont
  • Patent number: 10274465
    Abstract: The invention provides an apparatus for polymer chromatography, comprising at least one column that comprises a first stationary phase comprising one of the following: A) a material comprising at least one non-carbon atom, excluding glass or a metal, selected from molybdenum sulfide MoS2, tungsten sulfide WS2, silicon carbide SiC, boron nitride BN, or combinations thereof, or B) glass, or a metal, or combinations thereof, and a material comprising at least one non-carbon atom selected from molybdenum sulfide MoS2, tungsten sulfide WS2, silicon carbide SiC, boron nitride BN, or combinations thereof. The invention also provides a method for polymer chromatography, comprising introducing a solution, comprising a polymer, into a liquid flowing through a first stationary phase, and wherein the first stationary phase comprises one of foregoing materials (A) or (B).
    Type: Grant
    Filed: June 1, 2012
    Date of Patent: April 30, 2019
    Assignee: Dow Global Technologies LLC
    Inventors: Rongjuan Cong, Charles M. Cheatham, Al Parrott, Wallace W. Yau, Lonnie G. Hazlitt, Zhe Zhou, Alexander W. Degroot, Matthew D. Miller
  • Patent number: 10246472
    Abstract: Guanidine-functionalized particles and methods of making and using such particles.
    Type: Grant
    Filed: April 17, 2017
    Date of Patent: April 2, 2019
    Assignee: 3M Innovative Properties Company
    Inventors: George W. Griesgraber, Robert T. Fitzsimons, Jr., Douglas A. Hanggi, Masayuki Nakamura, Jerald K. Rasmussen
  • Patent number: 10247715
    Abstract: A sensor for detecting an analyte in a liquid. The sensor includes an antenna, covered with a layer of a molecularly imprinted polymer capable of interacting with an analyte and inducing a variation in the characteristics of the antenna within the microwave frequency range.
    Type: Grant
    Filed: June 25, 2015
    Date of Patent: April 2, 2019
    Assignees: Universite De Bourgogne, Institut National Superieur Des Sciences Agronomiques De L'alimentation Et De L'environnement
    Inventors: Jerome Rossignol, Elias Bou-Maroun, Celine Lafarge, Didier Stuerga, Philippe Cayot
  • Patent number: 10244582
    Abstract: A heater element having an electrically insulating substrate, a buss layer made of a conductive material, and a resistive layer that includes a first patch of a first resistive material. The first buss layer has a first buss and a second buss extending from terminals of the heater element to a heating area of the heater element. The first resistive material is applied in a first selected location in the heating area so as to provide electrical communication between the first buss and the second buss and to enable an electrical current to flow through the first resistive material. The resistive layer includes a second patch of a second resistive material. The second patch is applied in a second selected location in the heating area so as to provide electrical communication between the first buss and the second buss, the second selected location being different from the first selected location.
    Type: Grant
    Filed: October 22, 2015
    Date of Patent: March 26, 2019
    Assignee: IEE INTERNATIONAL ELECTRONICS & ENGINEERING S.A.
    Inventor: Pino Giuseppe Carenza
  • Patent number: 10215740
    Abstract: The present invention relates to a method for manufacturing a chromatography column, in particular for a gas phase chromatography, comprising a stationary phase made from a sol. This method comprises the following steps: (a) introducing this sol at the first end of the column, (b) moving said sol towards the second end of the column, so that a sol layer is formed on the internal wall of the column, this layer being able to form a gel on said internal wall, and (c) drying of the gel. The present invention also relates to a capillary column as well as to a microcolumn which may be manufactured according to this method.
    Type: Grant
    Filed: July 28, 2014
    Date of Patent: February 26, 2019
    Assignees: Commissariat à l'énergie atomique et aux énergies alternatives, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFQUE, UNIVERSITE Claude Bernard LYON 1, CPE Lyon FCR
    Inventors: David Lefebvre, Bernadette Charleux, Florence Ricoul, Chloe Thieuleux
  • Patent number: 10209217
    Abstract: Devices and methods for characterization of analyte mixtures are provided. Some methods described herein include performing enrichment steps on a device before expelling enriched analyte fractions from the device for subsequent analysis. Also included are devices for performing these enrichment steps.
    Type: Grant
    Filed: September 19, 2017
    Date of Patent: February 19, 2019
    Assignee: Intabio, Inc.
    Inventor: Erik Gentalen
  • Patent number: 10207229
    Abstract: The disclosure relates to a process and related article for functionalizing a porous membrane by contacting the membrane with a polyacid polymer at low pH to stably adsorb a polyacid layer on the membrane pore surface. The resulting functionalized membrane is characterized by a high density of free acid groups, resulting in a higher specific capacity for its intended application. The process allows functionalization of porous membranes in a very simple, one-step process. Such functional membranes may find multiple uses, including rapid, selective binding of proteins for their purification or immobilization.
    Type: Grant
    Filed: August 30, 2016
    Date of Patent: February 19, 2019
    Assignee: BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY
    Inventors: Merlin L. Bruening, Gregory L. Baker, Somnath Bhattacharjee, Yiding Ma
  • Patent number: 10175217
    Abstract: A method for recovering a metal, capable of suppressing variations in complex recovery yields among samples is described, wherein the method comprises: forming a complex between a metal in a sample and a chelating agent for metal in a mixture containing the sample and the chelating agent; and filtering the mixture in the presence of an inorganic salt to recover the complex, thereby recovering the metal in the sample.
    Type: Grant
    Filed: February 26, 2015
    Date of Patent: January 8, 2019
    Assignee: ARKRAY, Inc.
    Inventor: Akitsugu Kudo
  • Patent number: 10159911
    Abstract: The present invention provides novel chromatographic materials, e.g., for chromatographic separations, processes for its preparation and separations devices containing the chromatographic material; separations devices, chromatographic columns and kits comprising the same; and methods for the preparation thereof. The chromatographic materials of the invention are high purity chromatographic materials comprising a chromatographic surface wherein the chromatographic surface comprises a hydrophobic surface group and one or more ionizable modifier.
    Type: Grant
    Filed: January 25, 2013
    Date of Patent: December 25, 2018
    Assignee: Waters Technologies Corporation
    Inventors: Kevin Daniel Wyndham, Pamela C. Iraneta, Thomas H. Walter
  • Patent number: 10155177
    Abstract: A liquid-chromatography module includes a microfluidic cartridge housing a microfluidic substrate with a channel for transporting fluid. The microfluidic substrate has fluidic apertures through which fluid is supplied to the channel. One side of the cartridge has nozzle openings, each aligning with a fluidic aperture in the microfluidic substrate and receiving a fluidic nozzle. A clamping assembly has a plunger that is movable into a clamped position and an end housing that defines a chamber. One wall of the end housing has a fluidic block with fluidic nozzles extending into the chamber. A second wall has a slot through which the cartridge enters the chamber. When moved into the clamped position while the cartridge is in the chamber, the plunger urges the cartridge against the fluidic block such that each fluidic nozzle enters one nozzle opening and establishes fluidic communication with one fluidic aperture in the microfluidic substrate.
    Type: Grant
    Filed: June 23, 2015
    Date of Patent: December 18, 2018
    Assignee: WATERS TECHNOLOGIES CORPORATION
    Inventors: David P. Prentice, Russell L. Keene, Stanislaw Koziol, Joseph D. Michienzi, Paul E. Linderson, Gary W. Bertone
  • Patent number: 10145835
    Abstract: The present invention relates to a system of analysis, which can be used in a mobile laboratory in a drilling site situation or in a similar situation, suitable for measuring (preferably in relation to at least two partially gaseous species, which derive preferably from a mixture extracted from a drilling mud, for example, methane, ethane, propane and/or any other heavier hydrocarbons) the quantities of the different isotopes of at least a same chemical element (preferably the quantities of 13C, carbon isotope with 6 protons and 7 neutrons, and of 12C, carbon isotope with 6 protons and 6 neutrons, respectively) by means of a laser isotopes analyzer regulated for a single, at least partially gaseous species which contains said chemical element.
    Type: Grant
    Filed: August 15, 2016
    Date of Patent: December 4, 2018
    Assignee: GEOLOG S.R.L.
    Inventor: Antonio Calleri
  • Patent number: 10093919
    Abstract: Methods for automated extraction of nucleic acids are disclosed. Also disclosed are method and kits for isolating fetal nucleic acids from a plasma sample of a pregnant woman. The method includes flowing the plasma sample through a first filter under conditions that allow binding of the fetal and maternal nucleic acids to the first filter; eluting the fetal and maternal nucleic acids bound to the first filter to produce a concentrated nucleic acid sample; flowing the concentrated nucleic acid sample through a second filter under conditions that allow preferential binding of the maternal nucleic acids to the second filter; and recovering the fetal nucleic acid from the concentrated nucleic acid sample that flow through the second filter.
    Type: Grant
    Filed: July 20, 2016
    Date of Patent: October 9, 2018
    Assignee: Akonni Biosystems, Inc.
    Inventors: Rebecca Holmberg, Alissa Erin Burkey, Tinsley Janna Stokes, Phillip Belgrader
  • Patent number: 10052567
    Abstract: The current invention is directed to a chromatography column separator which separates the chromatography column in an upper chromatography column chamber and a lower chromatography column chamber, and which has a variable position within the chromatography column, and which is embedded by the chromatography material. The separator allows the replacement of the chromatography material in the upper chromatography column chamber without the need to replace the chromatography column material in the lower chromatography column chamber and it allows also the combination of two different chromatography materials with different chromatographical functional groups in one chromatography column.
    Type: Grant
    Filed: January 26, 2016
    Date of Patent: August 21, 2018
    Assignee: HOFFMANN-LA ROCHE INC.
    Inventors: Andreas Blaschyk, Roberto Falkenstein
  • Patent number: 10048173
    Abstract: Disclosed are an apparatus for analyte sampling, and a method of analyte sampling and an analyte sampling analysis system using the same.
    Type: Grant
    Filed: May 27, 2014
    Date of Patent: August 14, 2018
    Assignee: NVISANA CO., LTD.
    Inventors: Pil-kwon Jun, Yong-ik Sung
  • Patent number: 10032612
    Abstract: A method of ion mapping is disclosed comprising depositing a sample onto a target surface and separating the sample on the target surface according to a first physico-chemical property in a first dimension and according to a second physico-chemical property in a second dimension. The method further comprises ionising and mass analysing multiple separate regions of the sample so as to generate an ion map of at least a portion of the sample deposited upon the target surface. The sample is deposited onto and separated on the target surface by mechanical, hydrodynamic and/or aerodynamic means.
    Type: Grant
    Filed: March 27, 2017
    Date of Patent: July 24, 2018
    Assignee: MICROMASS UK LIMITED
    Inventors: Stevan Bajic, Paul Robert Murray, Mark William Towers
  • Patent number: 10017684
    Abstract: A method of hydraulic fracturing, and tracer composites for use in the fracturing procedure, for tracing the production of formation water from one or more fractured zones. The tracer composites preferably include a formation water tracer material adsorbed onto a solid carrier material.
    Type: Grant
    Filed: April 20, 2016
    Date of Patent: July 10, 2018
    Assignee: Spectrum Tracer Services, LLC
    Inventors: Jeffrey David Rule, Steve Allen Faurot
  • Patent number: 9963669
    Abstract: The invention concerns a facility for coupling a bioreactor for culturing bio-organisms, in dynamic mode, with at least one device for physicochemically analyzing a fluid from this bioreactor or collecting samples of this fluid, the device being equipped with a pump and an injector, the bioreactor being equipped with means for supplying culture medium and xenobiotic(s). The facility is remarkable in that the bioreactor is connected to a closed perfusion loop provided with a pump, fitted with a sampling loop and in that the facility comprises: a device for injecting a cleaning product into said sampling loop, two six-way valves, the first valve being connected to the closed perfusion loop, to the sampling loop and to a cleaning loop, the second valve being connected to the cleaning loop and an injection loop that connects the injector to at least one of the devices.
    Type: Grant
    Filed: December 1, 2014
    Date of Patent: May 8, 2018
    Assignees: Universite Technologie De Compiegne—UTC, Centre National de la Recherche Scientifique (CNRS)
    Inventors: Eric Leclerc, Patrick Paullier, Franck Merlier
  • Patent number: 9950278
    Abstract: A chromatography column includes a shell containing packed stationary phase and includes an inlet and an outlet at one end of the shell. A plastic sleeve is positioned in the shell to isolate the stationary phase from the shell. A capillary tube extends from an upstream inlet at the one end of the shell to deliver mobile phase to the upstream end of the stationary phase. Mobile phase travels through the stationary phase and exits the column at the one end. Porous filters and seals are provided. A removable coupling adapter is attached to the one end of the column and provides short flow paths and connection ports for the column inlet and outlet. The coupling adapter may incorporate other chromatography components, such as temperature control elements or flow cell optical detectors.
    Type: Grant
    Filed: April 1, 2016
    Date of Patent: April 24, 2018
    Inventor: Yury Zelechonok
  • Patent number: 9950301
    Abstract: A mixing machine 1 comprising a mixing head 3 having element(s) for connecting to a receptacle to form a mixing container. The mixing head 3 is pivotably supported in a frame 2 such that the mixing container can pivot for the mixing process. The mixing head 3 has at least one rotationally driven mixing tool whose drive shaft 23 extends through the wall of the mixing head 3. The mixing head 3 has a double wall with a perforated inner wall 8. The perforations form a fluid path from the chamber surrounded by the inner wall 8 to the intermediate wall chamber 10. The intermediate wall chamber 10 is connected to a pressure adjustment device for adjusting the pressure. A flexible liner 15 is arranged in the mixing head 3 on its inner surface, which liner 15 can be fixed to the inner wall 8 of the mixing head by applying a vacuum.
    Type: Grant
    Filed: June 23, 2016
    Date of Patent: April 24, 2018
    Assignee: DR. HERFELD GMBH & CO. KG
    Inventors: Wolfgang Rüberg, Ulrich Tölle
  • Patent number: 9897578
    Abstract: A chromatography column (2) containing a bed of packed particles (22, 24, 26, 28, 30), wherein the packed particles comprise fused core particles and the particle diameters of the packed particles vary along the column. Preferably, the particles (2, 24, 26, 28, 30) are arranged according to their average particle diameter, in order of increasing average particle diameter from the inlet end (4) to the outlet end (6). The bed may comprise a plurality of bed sections and each bed section has an average particle diameter calculated from the particles in that section and there are at least two different average particle diameter bed sections, wherein the particles of each bed are separated from particles of an adjacent bed by a partition that is liquid permeable to allow through a flow of mobile phase. A high column efficiency can be provided with lower pressure drop per unit length of the column.
    Type: Grant
    Filed: September 19, 2013
    Date of Patent: February 20, 2018
    Assignee: Thermo Electron Manufacturing Limited
    Inventor: Harald Ritchie
  • Patent number: 9851306
    Abstract: A measurement device includes mechanical support elements (101-104) for supporting a sample well, other mechanical support elements (105-109) for supporting a measurement head (112) suitable for optical measurements, and a control system (111) configured to control the measurement head to carry out at least two optical measurements from at least two different measurement locations inside the sample well, where each measurement location is a center point of a capture range from which radiation is captured in the respective optical measurement. The final measurement result is formed from the results of the at least two optical measurements in accordance with a pre-determined rule. The use of the at least two optical measurements from different measurement locations reduces measurement variation in situations where the sample well (153) contains a piece (158) of sample carrier.
    Type: Grant
    Filed: April 2, 2012
    Date of Patent: December 26, 2017
    Assignee: WALLAC OY
    Inventor: Ville Laitala
  • Patent number: 9842702
    Abstract: Fabricating a capacitor includes performing an oxide formation operation on a sheet of material. The oxide formation operation forms an anode metal oxide on an anode metal. A thermal compression is performed on the sheet of material after the oxide formation operation is performed. The thermal compression applies thermal energy to the sheet of material while applying pressure to the sheet of material. After the thermal compression, the capacitor is assembled such that at least one electrode in the capacitor includes at least a portion of the sheet of material.
    Type: Grant
    Filed: June 9, 2017
    Date of Patent: December 12, 2017
    Assignee: Pacesetter, Inc.
    Inventors: David R. Bowen, Ralph Jason Hemphill
  • Patent number: 9828443
    Abstract: Polydisperse and charged polysaccharides are fractionated into low polydispersity fractions (preferably having pd<1.1), each containing species within a narrow range of molecular weights. An aqueous solution of the polydisperse polysaccharides is contacted with an ion exchange resin in a column and the polysaccharides are subjected to selective elution by aqueous elution buffer. The selective elution consists of at least 3 sequential elution buffers having different and constant ionic strength and/or pH and in which the subsequent buffers have ionic strength and/or pH than those of the preceding step. The new preparations are particularly suitable for the production of PSA-derivatized therapeutic agents intended for use in humans and animals.
    Type: Grant
    Filed: October 27, 2015
    Date of Patent: November 28, 2017
    Assignee: LIPOXEN TECHNOLOGIES LIMITED
    Inventors: Sanjay Jain, Ioannis Papaioannou, Peter Laing
  • Patent number: 9821250
    Abstract: In a preparative separation-purification system for passing a solution containing a target component through a trap column to capture the target component in the column, and for subsequently passing an eluting solvent through the column to elute the captured component and collect it in a container, a dilution passage is merged with a collection passage for sending an eluate from the outlet end of the trap column to the collection container, and a diluting liquid is intermittently introduced through the dilution passage into the collection passage. The diluting liquid lowers the concentration of the target component in the eluate and impedes the deposition of the target component. Thus, clogging of the passage due to the deposition of the target component eluted from the trap column is effectively prevented.
    Type: Grant
    Filed: May 13, 2013
    Date of Patent: November 21, 2017
    Assignee: Shimadzu Corporation
    Inventors: Tomoyuki Yamazaki, Przemyslaw Stasica, Bob Boughtflower
  • Patent number: 9790288
    Abstract: Polydisperse and charged polysaccharides are fractionated into low polydispersity fractions (preferably having pd<1.1), each containing species within a narrow range of molecular weights. An aqueous solution of the polydisperse polysaccharides is contacted with an ion exchange resin in a column and the polysaccharides are subjected to selective elution by aqueous elution buffer. The selective elution consists of at least 3 sequential elution buffers having different and constant ionic strength and/or pH and in which the subsequent buffers have ionic strength and/or pH than those of the preceding step. The new preparations are particularly suitable for the production of PSA-derivatised therapeutic agents intended for use in humans and animals.
    Type: Grant
    Filed: October 27, 2015
    Date of Patent: October 17, 2017
    Assignee: LIPOXEN TECHNOLOGIES LIMITED
    Inventors: Sanjay Jain, Ioannis Papaioannou, Peter Laing
  • Patent number: 9776945
    Abstract: Processes for separating a di-carboxylic acid or salt thereof from a mixture containing the di-carboxylic acid or salt thereof and one or more other components are provided. Also separation media useful for these separation processes is provided. In particular, processes for preparing an aldaric acid are described, such as glucaric acid from glucose, which includes separating the aldaric acid from the reaction product. Also, various glucaric acid products are described.
    Type: Grant
    Filed: September 29, 2015
    Date of Patent: October 3, 2017
    Assignee: Rennovia Inc.
    Inventors: Gary M. Diamond, Eric L. Dias, Raymond Archer, Vincent J. Murphy, Thomas R. Boussie
  • Patent number: 9764251
    Abstract: A supercritical fluid chromatography system is provided with an injection valve subsystem for introducing a sample into a flow of mobile phase fluid. The injection valve subsystem includes an auxiliary valve and an inject valve. The operations of the auxiliary and inject valves are coordinated in such a manner as to reduce sample carry-over and system pressure perturbations occurring during sample injection.
    Type: Grant
    Filed: March 5, 2013
    Date of Patent: September 19, 2017
    Assignee: Waters Technologies Corporation
    Inventors: Emily J. Berg, Joshua A. Shreve, James E. Usowicz, Douglas P. Wittmer, Aaron Lebeau
  • Patent number: 9766214
    Abstract: A supercritical fluid chromatograph includes a supercritical flow path, a mobile phase supply section for supplying a mobile phase containing liquid carbon dioxide, a sample introduction section, a sample separation section, a detector, and a pressure control valve. A valve post-stage flow path is connected to a fluid outlet of the pressure control valve, and the inside of the valve post-stage flow path is maintained by pressure maintaining means at a pressure by which a mobile phase from the fluid outlet of the pressure control valve is not vaporized.
    Type: Grant
    Filed: November 28, 2012
    Date of Patent: September 19, 2017
    Assignee: SHIMADZU CORPORATION
    Inventors: Hiroomi Goto, Tsunehiro Inoue, Takahiro Mori, Hirohisa Abe
  • Patent number: 9759734
    Abstract: The present invention aims at providing an analyzing apparatus control system which is capable of appropriately setting the conditions of measurement in an analyzing apparatus which is connected to a chromatograph, in which one more measurement events are performed based on a reference chromatogram. This system includes a measurement time range setting section for setting, for each of all peaks or previously selected peak or peaks included in a previously provided reference chromatogram which corresponds to the sample to be examined, the width of a peak as the measurement time range of the peak when the peak does not overlap another peak, or, when the peak overlaps another peak, the overall width of the peak and the overlapping peak as the measurement time range of the peak.
    Type: Grant
    Filed: July 18, 2012
    Date of Patent: September 12, 2017
    Assignee: Shimadzu Corporation
    Inventor: Tohru Shiohama
  • Patent number: 9650411
    Abstract: The present invention relates to a method for purifying a protein by separating the protein from impurities in a non-adsorption mode using an activated carbon. In particular, the present invention relates to a method for purifying an antibody using the activated carbon instead of protein A affinity chromatography.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: May 16, 2017
    Assignee: KYOWA HAKKO KIRIN CO., LTD.
    Inventor: Takashi Ishihara
  • Patent number: 9638178
    Abstract: An ion electrospray device with a porous reservoir and at least one porous emitter includes a porous compliant interface sandwiched between the porous reservoir and the porous emitter for transferring fluid from the porous reservoir to the porous emitter. The interface has a characteristic capillary pressure stronger than the characteristic capillary pressure of the porous reservoir to fill the porous emitter with fluid via a fluid injection section of the interface and before the porous reservoir is then partially filled with fluid. Emitter leakage and propellant bridging problems are addressed.
    Type: Grant
    Filed: April 14, 2016
    Date of Patent: May 2, 2017
    Assignee: Busek Co., Inc.
    Inventors: Daniel Courtney, Nathaniel Demmons, Peter Wright
  • Patent number: 9610712
    Abstract: The embodiments disclose a method of surface tension control to reduce trapped gas bubbles in an imprint including modifying chemistry aspects of interfacial surfaces of an imprint template and a substrate to modify surface tensions, differentiating the interfacial surface tensions to control interfacial flow rates of a pre-cured liquid resist and controlling pre-cured liquid resist interfacial flow rates to reduce trapping gas and prevent trapped gas bubble defects in cured imprinted resist.
    Type: Grant
    Filed: February 16, 2016
    Date of Patent: April 4, 2017
    Assignee: Seagate Technology LLC
    Inventors: Sang-Min Park, Nobuo Kurataka, Gennady Gauzner
  • Patent number: 9597686
    Abstract: A serviceable system for handling fluids in microgravity includes supply reservoirs to hold a supply fluid for a process, a fluid processing unit to perform the process and a collection reservoir to collect a fluid from the fluid processing unit. Each supply reservoirs is provided with a supply valve assembly of valves and conduits, and at least one external conduit that is connectable to an external fluid source or to an external suction source. The supply valve assembly is configured to enable individually: flow of the supply fluid from the supply reservoir to the fluid processing unit, flow of a fluid into the supply reservoir from the external conduit; withdrawal of fluid from supply reservoir to the external conduit, and flow of fluid from the external conduit to the fluid processing unit.
    Type: Grant
    Filed: August 31, 2015
    Date of Patent: March 21, 2017
    Assignee: SPACEPHARMA SA
    Inventors: Yair Feuchtwanger, Molly K. Mulligan, Ira Naot, Alexander Pekin
  • Patent number: 9579278
    Abstract: The present invention relates to a skin care composition comprising an extract of Bursera simaruba seeds and a cosmetically acceptable topical carrier. Such composition is useful for improving skin barrier function and moisturization as well as improving signs of skin aging.
    Type: Grant
    Filed: May 10, 2013
    Date of Patent: February 28, 2017
    Assignee: Johnson & Johnson Consumer Inc.
    Inventors: Suhyoun Chon, Ya-Ping Hu, Khalid Mahmood, Apostolos Pappas, Ramine Parsa, Kurt A. Reynertson, Michael D. Southall