Chromatography Patents (Class 210/656)
  • Patent number: 10968443
    Abstract: The disclosure provides methods for isolating nucleic acids from a biological fluid. In one aspect, the disclosure provides a method for isolating RNA. In another aspect, the disclosure provides a method for isolating DNA. In one aspect, the methods described herein utilize a protocol that combines a detergent-based initial denaturation, protease digestion, and organic extraction followed by column purification that maximizes RNA/DNA yield and preserves RNA/DNA integrity. In yet another aspect, the disclosure provides a kit for isolating RNA and/or DNA.
    Type: Grant
    Filed: December 31, 2015
    Date of Patent: April 6, 2021
    Assignee: THE ROCKEFELLER UNIVERSITY
    Inventors: Klaas Max, Karl Bertram, Kemal Akat, Thomas H. Tuschl, Jenny Li, Kimberly Bogardus
  • Patent number: 10955391
    Abstract: A chromatography system has an associated system volume and a sample dispersion volume. The chromatography system comprises a pump pumping a flow of gradient, a sample manager for introducing a sample into the flow of gradient, and a valve manager fluidically coupled to the pump and to the sample manager. The valve manager includes at least one valve. A first valve of the at least one valve has a plurality of ports including an inlet port that receives the flow of gradient from the pump and an outlet port through which the flow of gradient exits the first valve. The first valve has at least two different, automatically selectable positions. A first position of the at least two different automatically selectable positions operating to change one of the system and sample dispersion volumes of the chromatography system when the first valve is automatically switched into the first position.
    Type: Grant
    Filed: February 17, 2016
    Date of Patent: March 23, 2021
    Assignee: WATERS TECHNOLOGIES CORPORATION
    Inventors: Sylvain Cormier, Richard W. Andrews, Peyton C. Beals
  • Patent number: 10940401
    Abstract: The present invention provides methods for cleaning or regenerating a chromatography materiel for reuse. The methods of the invention can be used for cleaning or regenerating chromatography columns for reuse in the large-scale manufacture of multiple polypeptide products.
    Type: Grant
    Filed: March 13, 2018
    Date of Patent: March 9, 2021
    Assignee: GENENTECH, INC.
    Inventors: Ekta Mahajan, Joanna So, Jay Werber
  • Patent number: 10933349
    Abstract: An arrangement for mounting components in a heating chamber for heating a fluid of a fluid separation apparatus, wherein the arrangement comprises a mounting board having at least one mounting recess each configured for accommodating at least one component, and the at least one component each configured to be mountable in and/or on the at least one mounting recess.
    Type: Grant
    Filed: January 13, 2015
    Date of Patent: March 2, 2021
    Assignee: Agilent Technologies, Inc.
    Inventors: Ansgar Waldbaur, Armin Steinke, Ralf Schaeffer
  • Patent number: 10928367
    Abstract: A peak extraction method for extracting a true peak from a measured waveform, including acquiring a second derivative waveform; extracting a provisional peak on the basis of a maximum value and/or a minimum value of the second derivative waveform; determining the peak width of the provisional peak on the basis of a model peak function; computing, on the basis of the model peak function, a theoretical value for the height of the provisional peak using two points corresponding to the two ends of the peak width; computing, based on the second derivative waveform, an index value for a variation in the noise on the measured waveform; and computing an S/N ratio, which is a ratio of the peak height theoretical value and the index value, and extracting the provisional peak that is equal to or greater than a preset value as the true peak.
    Type: Grant
    Filed: February 3, 2016
    Date of Patent: February 23, 2021
    Assignee: SHIMADZU CORPORATION
    Inventor: Hiroaki Kozawa
  • Patent number: 10907014
    Abstract: Compositions including one or more polymers are provided. Exemplary polymers include polymeric carbon monoxides. The compositions can be prepared by subjecting a source material to x-rays, optionally at increased pressures. The compositions can be used in a variety of applications, such as fuels, optics, and electronics.
    Type: Grant
    Filed: August 15, 2016
    Date of Patent: February 2, 2021
    Assignee: THE BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION ON BEHALF OF THE UNIVERSITY OF NEVADA, LAS VEGAS
    Inventor: Michael Pravica
  • Patent number: 10900892
    Abstract: There is provided a method of validating a calibration of a sensor represented by a calibrated relationship between concentration of an analyte in a sample and measurements from a sensor of an optical property of a sensing substance, wherein the optical property of the sensing substance has a spectrum that varies with the concentration of the analyte in the sample, and the spectrum has an isosbestic wavelength at which the optical property does not vary with concentration of the analyte, the method comprising making measurements of the optical property at three or more wavelengths of light while the sensing substance is exposed to the sample, determining whether the measurements of the optical property are inconsistent with the calibrated relationship, and outputting a warning signal in response to the measurements of the optical property being inconsistent with the calibrated relationship.
    Type: Grant
    Filed: February 17, 2020
    Date of Patent: January 26, 2021
    Assignee: SciLogica Corp.
    Inventors: Alasdair Allan Mackenzie, Barry Colin Crane, Nicholas Paul Barwell, Praveen Sagar, Robert Perkins
  • Patent number: 10759681
    Abstract: The present disclosure relates to water purification compositions and the method of producing the same. Specifically, the present disclosure relates to compositions containing a substrate that has hydroxyl, thiol, carboxyl or amino groups, a metal oxide, and a carboxylic acid compound, and the method of producing the same. The composition is useful for the removal of soluble phosphorus, selenium, fluoride, arsenic and other heavy metal contaminants that may be present in water. The composition could be of use in numerous fields, including but not limited to, oil and gas, mining, storm water, agricultural runoffs, municipal wastewater, and industrial wastewater.
    Type: Grant
    Filed: June 28, 2018
    Date of Patent: September 1, 2020
    Assignee: BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS
    Inventor: Tito Viswanathan
  • Patent number: 10761072
    Abstract: A temperature gradient chromatography, and apparatus for the same, said method comprising the following: a) dissolving a composition comprising at least one polymer in at least one solvent, to form a polymer solution; b) injecting at least a portion of the polymer solution onto a support material and wherein the support material has a CI from 0.70 to 1.50; c) cooling the support material at a rate greater than, or equal to, 0.2° C./min; d) increasing the temperature of the support material to elute at least some of the polymer; e) generating the chromatogram.
    Type: Grant
    Filed: August 24, 2016
    Date of Patent: September 1, 2020
    Assignee: DOW Global Technologies LLC
    Inventors: Rongjuan Cong, Albert Parrott, Cherry Hollis, Charles Michael Cheatham
  • Patent number: 10753915
    Abstract: A method for analyzing and quantifying a panel of drugs in a clinical sample comprises: trapping a first portion of drug parent compounds and their metabolites on a first chromatographic column; trapping a second portion of the drug parent compounds and their metabolites on a second chromatographic column; separately eluting the first and second portions of the drug parent compounds and their metabolites from the first and second chromatographic columns; detecting concentrations of each of the drug parent compounds and metabolites eluted from each of the first and second chromatographic columns with a detector; and summing the detected concentration of each drug parent compound together with the detected concentrations of all of its respective analytes so as to derive a respective total concentration of each drug in the sample.
    Type: Grant
    Filed: July 27, 2016
    Date of Patent: August 25, 2020
    Assignee: Thermo Finnigan LLC
    Inventors: Joseph Herman, Sarah J. Fair, Dayana Argoti
  • Patent number: 10753680
    Abstract: A method for separating carbon dioxide from flue gas to generate a high purity CO2 stream.
    Type: Grant
    Filed: March 23, 2018
    Date of Patent: August 25, 2020
    Assignee: GENERAL ELECTRIC TECHNOLOGY GMBH
    Inventors: Andrea Caruso, Olaf Stallmann, Markus Jorg Weitzel, Christian Karl Britz
  • Patent number: 10732153
    Abstract: A preparative purification apparatus capable of adjusting a mixing ratio of a mobile phase and an elution solvent contained in a solution to be collected. A liquid feeding unit which feeds an elution solvent to an inlet of a trap column; a flow path switching unit which selectively connects an outlet of the trap column to one of a waste liquid flow path or a recovery flow path; a liquid feed amount measurement unit; and a flow path control unit which performs a control such that the flow path switching unit is connected to the recovery flow path when the amount of the elution solvent fed to the trap column reaches a predetermined initial waste liquid amount, and thereafter, the flow path switching unit is connected to the waste liquid flow path at a timing of reaching a predetermined solution recovery amount.
    Type: Grant
    Filed: August 24, 2015
    Date of Patent: August 4, 2020
    Assignee: Shimadzu Corporation
    Inventors: Tomoyuki Yamazaki, Yosuke Iwata
  • Patent number: 10697944
    Abstract: A portable system 1 for analyzing gaseous flows that vary over time is described, the system comprising a sampling chamber 18, a gas sampling module 7, an ion filtering module 8 and an ion detecting module 9. The gas sampling module 7 is configured to adjust an input gaseous flow Fi of gas particles from the sampling chamber 18, ionize said gas particles and to emit the produced ions, so as to generate an ion flow I. The ion filtering module 8 is configured to controllably select at least one type of ion present in the ion flow I and to generate a corresponding at least one homogeneous ion beam I?, having an intensity representative of the concentration of the corresponding gas particle in the gaseous composition to be analyzed. The ion detecting module 9 is configured to measure the intensity of the at least one ion beam I?.
    Type: Grant
    Filed: July 2, 2015
    Date of Patent: June 30, 2020
    Assignee: Nanotech Analysis S.R.L.
    Inventors: Gianpiero Mensa, Raffaele Correale
  • Patent number: 10684286
    Abstract: The invention provides a method for analyzing a protamine sample for the presence or amount of at least one nucleotidic impurity. The invention also provides a method for the quantitation of peptides in a sample of protamine comprising four major peptides and at least one related impurity.
    Type: Grant
    Filed: April 6, 2017
    Date of Patent: June 16, 2020
    Assignee: Fresenius Kabi USA, LLC
    Inventors: Pearle Torralba, David Jeschke, Kamlesh Patel
  • Patent number: 10684263
    Abstract: A device including a chromatogram display section; a peak-specifying point detector automatically detecting a peak-beginning point on a displayed chromatogram; a peak-specifying point indicator allowing an operator to indicate, as the point in time of a peak-ending point, a point in time on a time axis of an orthogonal coordinate system; a peak-specifying-point candidate designator designating a point at which a straight line extending parallel to the intensity axis and passing through the point in time of the peak-ending point indicated by the peak-specifying point indicator intersects with the chromatogram and a point at which a straight line extending parallel to the time axis and passing through the peak-beginning point detected by the peak-specifying point detector intersects with the straight line extending parallel to the intensity axis and passing through the point in time of the peak-ending point; and a peak-specifying point selector allowing an operator to select either point.
    Type: Grant
    Filed: May 19, 2015
    Date of Patent: June 16, 2020
    Assignee: SHIMADZU CORPORATION
    Inventor: Momoyo Yamakawa
  • Patent number: 10669307
    Abstract: The present invention relates to a device for separating and/or isolating substances in or from a mixture with improved utilization of the capacity of chromatographic media, the device comprising a first chromatography system, a second chromatography matrix downstream of the first chromatography system, and a sensor for detecting the substances present in the fluid. Furthermore, the present invention relates to both the use of said device and a method for separating and/or isolating substances in or from a mixture in a fluid.
    Type: Grant
    Filed: May 12, 2015
    Date of Patent: June 2, 2020
    Assignee: Sartorius Stedim Biotech GmbH
    Inventors: Louis Villain, Jörg Mittelstät, Ana Raquel Santos De Matos Fortuna, Katrin Töppner
  • Patent number: 10661250
    Abstract: In embodiments, a packing material for supported liquid extraction has a sorbent media that includes synthetic silica particles. In embodiments, the synthetic silica particles can have physical properties relating to one or more of particle surface area, shape, size, or porosity. In one embodiment, synthetic silica particles have a surface area less than about 30 m2/g. In another embodiment, the synthetic silica particles have an approximately uniform particle shape. In further examples, synthetic silica particles have a particle size in a range of about 30-150 ?m inclusive or greater than about 200 ?m. In another embodiment, synthetic silica particles are arranged to have a pore size greater than about 500 Angstroms. In an embodiment, an apparatus for supported liquid extraction includes a container and a sorbent media that includes synthetic silica particles. In a further embodiment, a method for extracting target analytes through supported liquid extraction is provided.
    Type: Grant
    Filed: December 19, 2018
    Date of Patent: May 26, 2020
    Assignee: AGILENT TECHNOLOGIES, INC.
    Inventors: Kunqiang Jiang, Derick Lucas, Bruce Richter
  • Patent number: 10632461
    Abstract: According to one embodiment, a sealed chemical container has a bonding area where a flexible sheet-like member is firmly bonded onto a plate, and the bonding area defines a first compartment which can be swollen and an outflow passage which communicates with the first compartment via an opening. A first seal portion is weakly bonded onto the plate compared to the bonding area to define the first compartment to block communication between the first compartment and an outflow passage. The first seal portion is peeled off by an increase in internal pressure in the first compartment to allow communication between the first compartment and the outflow passage.
    Type: Grant
    Filed: September 28, 2017
    Date of Patent: April 28, 2020
    Assignee: Canon Medical Systems Corporation
    Inventors: Hiroaki Kushima, Nobuo Kawamura, Tetsuya Kuwabara, Sotaro Taki
  • Patent number: 10627289
    Abstract: An improved method for integrating curve peaks as compared to techniques such as the trapezoidal rule wherein integration parameters are at fixed x-axis positions. Integration parameters are instead specified relative to a peak center, which allows the peak to shift over time due to hardware changes, temperature fluctuation, pressure changes, etc., while maintaining integration parameters at optimal locations for that peak. As such, the present disclosure finds particular utility in spectroscopy wherein, in the case of Raman spectroscopy, for example, specific wavenumber shift locations may drift over time, leading to inaccurate results based upon absolute integration parameters.
    Type: Grant
    Filed: October 19, 2018
    Date of Patent: April 21, 2020
    Assignee: Kaiser Optical Systems Inc.
    Inventor: Patrick Wiegand
  • Patent number: 10618951
    Abstract: The present invention relates to cell culture media containing combinations of proteins, as well as methods of making the cell culture media, and methods of using the cell culture media to improve growth characteristics of cultured cells.
    Type: Grant
    Filed: June 21, 2016
    Date of Patent: April 14, 2020
    Assignee: Ventria Biosciences Inc.
    Inventors: Steven Clyde Pettit, Mary Ann Michelle Fernandez Santos, Ning Huang
  • Patent number: 10604788
    Abstract: Methods and systems for processing polynucleotides (e.g., DNA) are disclosed. A processing region includes one or more surfaces (e.g., particle surfaces) modified with ligands that retain polynucleotides under a first set of conditions (e.g., temperature and pH) and release the polynucleotides under a second set of conditions (e.g., higher temperature and/or more basic pH). The processing region can be used to, for example, concentrate polynucleotides of a sample and/or separate inhibitors of amplification reactions from the polynucleotides. Microfluidic devices with a processing region are disclosed.
    Type: Grant
    Filed: August 29, 2019
    Date of Patent: March 31, 2020
    Assignee: HANDYLAB, INC.
    Inventors: Betty Wu, John S. Althaus, Nikhil Phadke, Sundaresh N. Brahmasandra, Kalyan Handique, Aaron Kehrer, Gene Parunak, Cecelia Haley, Ted Springer
  • Patent number: 10605671
    Abstract: To provide a chromatograph data processing device and the like that can estimate and calculate a retention index or a retention time that would be measured by performing programmed-temperature analysis with any desired rate of temperature increase from known retention indices measured by programmed-temperature analysis, a receiving unit that receives a rate of temperature increase, an RI-r relationship storage unit that stores an RI-r relationship, the RI-r relationship being a relationship between a retention index and a rate of temperature increase and being identified based on a plurality of retention indices with respect to different rates of temperature increase and the corresponding rates of temperature increase, and a retention index calculation unit that calculates an estimated retention index based on the RI-r relationship, the estimated retention index being a retention index corresponding to the received rate of temperature increase received by the receiving unit.
    Type: Grant
    Filed: December 9, 2014
    Date of Patent: March 31, 2020
    Assignee: HORIBA STEC, CO., LTD.
    Inventors: Tsuneaki Maeda, Nanako Sasaki
  • Patent number: 10596254
    Abstract: Highly effective vaccine compositions are constructed according to the methods of this invention. The methods are amenable to use with any peptidic antigen sequence and involve covalent attachment of an immunostimulatory nucleotide sequence to an antigenic peptide sequence. Preferred antigenic peptides are fusion peptides made up of one or more CTL epitope peptides in sequence fused to a T helper peptide.
    Type: Grant
    Filed: April 26, 2018
    Date of Patent: March 24, 2020
    Assignee: City of Hope
    Inventor: Don J. Diamond
  • Patent number: 10585076
    Abstract: A gas-liquid separator according to an embodiment of the present invention separates a mobile phase containing a gas and a liquid into a gas and a liquid. The gas-liquid separator according to the embodiment of the present invention includes an introduction flow channel to which a mobile phase is introduced, and a plurality of discharge flow channels connected to the introduction flow channel. A gas and a liquid are discharged from a discharge port of the discharge flow channel.
    Type: Grant
    Filed: September 17, 2014
    Date of Patent: March 10, 2020
    Assignee: SHIMADZU CORPORATION
    Inventors: Hiroomi Goto, Risa Kajiyama, Takahiro Mori
  • Patent number: 10525376
    Abstract: The present invention is directed to affinity chromatography devices that separate a targeted protein or antibody from an aqueous mixture containing the targeted protein or antibody. The chromatography device may contain a stacked membrane assembly or a wound membrane assembly. The membrane assemblies include at least one polymer membrane that contains therein inorganic particles. The polymer membrane and/or the inorganic particles have an affinity ligand bonded thereto. The affinity ligand may be a protein, an antibody, or a polysaccharide that reversibly binds to the targeted protein or antibody. The chromatography device may be repeatedly used and may be cleaned with a caustic solution between uses. The chromatography devices may have a dynamic binding capacity (DBC) of at least 30 mg/ml (or 0.07 micromol/ml) at 10% breakthrough at a residence time of 20 seconds or less.
    Type: Grant
    Filed: April 8, 2016
    Date of Patent: January 7, 2020
    Assignee: W. L. Gore & Associates, Inc.
    Inventor: Michael C. McManaway
  • Patent number: 10526367
    Abstract: The present invention is directed to affinity chromatography devices that separate a targeted protein or antibody from an aqueous mixture containing the targeted protein or antibody. The chromatography device may contain a stacked membrane assembly or a wound membrane assembly. The membrane assemblies include (1) at least one polymer membrane that contains therein inorganic particles and (2) at least one impermeable layer (e.g., a thermoplastic polymer in a solid state). The polymer membrane and/or the inorganic particles have an affinity ligand bonded thereto. The affinity ligand may be a protein, an antibody, or a polysaccharide that reversibly binds to the targeted protein or antibody. The chromatography device may be repeatedly used and may be cleaned with a caustic solution between uses. The chromatography devices has a dynamic binding capacity (DBC) of at least 30 mg/ml (or 0.07 micromol/ml) at 10% breakthrough at a residence time of 20 seconds or less.
    Type: Grant
    Filed: January 19, 2017
    Date of Patent: January 7, 2020
    Assignee: W. L. Gore & Associates, Inc.
    Inventors: Michael C. McManaway, Brian J. Swetlin, Kenneth S. Zukor
  • Patent number: 10520479
    Abstract: In a liquid chromatograph mass spectrometer (LC/MS) for performing mass spectrometry of fractionated samples prepared with a multi-dimensional LC or similar LC with high separatory capability, fractionated sample useful information which shows the degree of usefulness of various substances with respect to retention time is prepared from prior information which includes, for example, elution characteristics in the LC depending on the kind of column or other factors or the degree of ease of ionization in the MS. During a measurement, the preparative separation of an eluate and the preparation of fractionated samples are not performed within a period of time which has been judged to be useless based on the fractionated sample useful information. By selecting fractionated samples at each dimension of the multi-dimensional LC, the number of fractionated samples to be eventually subjected to mass spectrometry can be significantly reduced.
    Type: Grant
    Filed: September 8, 2014
    Date of Patent: December 31, 2019
    Assignee: SHIMADZU CORPORATION
    Inventors: Shinichi Utsunomiya, Yusaku Hioki, Yuki Ohta
  • Patent number: 10501862
    Abstract: A plating system comprising a plating tank for applying plate processing to a substrate, a sensor configured to measure actual plating film thickness of the substrate, and a controller configured to control plating current supplied to the plating tank and plating time for the plate processing of the substrate within the plating tank. The controller is capable of setting target plating film thickness, plating current, and plating time as a plate processing recipe. At least one of the plating current and the plating time is automatically corrected so that the actual plating film thickness and the target plating film thickness become equal to each other, and the result is reflected in the plate processing for the subsequent substrate.
    Type: Grant
    Filed: August 4, 2017
    Date of Patent: December 10, 2019
    Assignee: EBARA CORPORATION
    Inventors: Takashi Mitsuya, Ryuya Koizumi, Toshio Yokoyama, Masashi Shimoyama, Kunio Oishi
  • Patent number: 10494449
    Abstract: Polydisperse and charged polysaccharides are fractionated into low polydispersity fractions (preferably having pd<1.1), each containing species within a narrow range of molecular weights. An aqueous solution of the polydisperse polysaccharides is contacted with an ion exchange resin in a column and the polysaccharides are subjected to selective elution by aqueous elution buffer. The selective elution consists of at least 3 sequential elution buffers having different and constant ionic strength and/or pH and in which the subsequent buffers have ionic strength and/or pH than those of the preceding step. The new preparations are particularly suitable for the production of PSA-derivatised therapeutic agents intended for use in humans and animals.
    Type: Grant
    Filed: November 22, 2017
    Date of Patent: December 3, 2019
    Assignee: Lipoxen Technologies Limited
    Inventors: Sanjay Jain, Ioannis Papaioannou, Peter Laing
  • Patent number: 10489036
    Abstract: Systems and methods that facilitate the setup and visualization of a configurable process, for example a chromatography experiment to be conducted using a configurable chromatography system. A user interface displays category regions representing sections of a process, and displays a plurality of selectable items representing components appropriate for placement in the category regions. A user interface control causes selection of one of the selectable items and placement of the selected item into one of the category regions, to define a selected process configuration. The user interface control may be a scrolling control that causes a set of selectable items appropriate for placement in the respective category region to scroll through the category region. When the computer displaying the user interface is also connected to the system being configured, the user interface may also facilitate setup, monitoring, and control of the resulting process.
    Type: Grant
    Filed: October 14, 2015
    Date of Patent: November 26, 2019
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: Christof Schultz, Dominic Casenas, Farah Mavandadi
  • Patent number: 10486049
    Abstract: The invention relates to a device and method for monitoring a swimming performance. The device comprises one or more motion-sensitive sensors for providing motion data characteristic to the motion of the swimmer during said swimming performance and a computing unit adapted to detect body motions from said motion data using predefined criteria. According to the invention the computing unit comprises means for calculating a plurality of correlation factors depicting correlation of motion data between successive body motions detected, means for storing the correlation factors as a time series, and means for determining one or more parameters characteristic to the swimming performance based on said correlation factors stored. The invention can be used for robust determination of swimmer's turns, distance swum or swimming style, for example.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: November 26, 2019
    Assignee: Amer Sports Digital Services Oy
    Inventors: Heikki Nieminen, Markus Kemetter, Janne Kallio, Antti Virtanen
  • Patent number: 10481135
    Abstract: A device and method for the separation, detection, and identification of multiple individual components in a sample where the separation device is gas chromatograph or a microchip separation device. The chromatograph or microchip separation and detection device has a detector including a two dimensional or substantially two dimensional sensor material sensitive to and has a property change (such as a change in resistance) when the surface of the two dimensional or substantially two dimensional sensor material is exposed to a component of a sample in amounts as low as 10?21 grams of component.
    Type: Grant
    Filed: March 11, 2016
    Date of Patent: November 19, 2019
    Assignee: HOWARD UNIVERSITY
    Inventor: Joshua Halpern
  • Patent number: 10473574
    Abstract: There is provided an assembly and process for its preparation for predicting the permeability of chemical compounds, comprising a donor compartment for adding a composition comprising the compound; a barrier based on a support and a phospholipid layer adhering to the support; and an acceptor compartment for accepting the compound upon permeation of the barrier.
    Type: Grant
    Filed: November 17, 2015
    Date of Patent: November 12, 2019
    Assignee: Syddansk Universitet
    Inventors: Massimiliano Pio Di Cagno, Annette Bauer-Brandl
  • Patent number: 10463988
    Abstract: Methods and systems for chromatography are disclosed that employ a flexible container configured to fit within a support structure and adapted to receive a filtration or absorptive medium, such as a chromatography resin. The flexible container can include at least one inlet, at least one outlet, and a separation barrier peripherally sealed within the container to separate the container into a resin containing portion and a drainage portion. The barrier can be configured to exclude the resin material from the drainage portion during use while allowing fluids to pass therethrough. The disposable chromatography system can further include one or more agitators disposed within the flexible container and adjustably configured to be raised or lowered in the flexible container. When the agitator is in the raised position, the resin packing material can operate in a settled, packed-bed configuration.
    Type: Grant
    Filed: September 23, 2011
    Date of Patent: November 5, 2019
    Assignee: GE HEALTHCARE BIO-SCIENCES CORP.
    Inventors: John J. Vicalvi, Joseph Makowiecki, Joseph D. Crowell, Parrish M. Galliher
  • Patent number: 10413495
    Abstract: A method for forming a photosensitizer product that is resistant to absorption by living tissue that may include binding a photosensitizer compound with an oxide-containing particle to provide the photosensitizer derivative having a microscale size, and mixing the photosensitizer derivative into a lotion. The microscale size of the photosensitizer derivative obstructs absorption by cell tissue.
    Type: Grant
    Filed: November 17, 2016
    Date of Patent: September 17, 2019
    Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Scott B. King, Brandon M. Kobilka, Joseph Kuczynski, Jacob T. Porter, Jason T. Wertz
  • Patent number: 10383908
    Abstract: Methods are provided for inducing granulation tissue on third-degree burns present on the skin of a mammalian subject, which includes human subjects. A method according to the disclosure comprises contacting a third-degree burn wound with an extract of Hamelia patens, in combination with a dermatologically-acceptable carrier. Methods according to the disclosure are applicable to chemically-induced, electrically-induced, and thermally-induced third-degree burn wounds on skin.
    Type: Grant
    Filed: December 26, 2017
    Date of Patent: August 20, 2019
    Inventor: Don Wayne Berry
  • Patent number: 10344229
    Abstract: A method for determining a relationship between the ratio of solvent power to critical solvent power and the threshold light paraffin content of a hydrocarbon fluid is provided. The method comprises: dividing the plurality of hydrocarbon fluids into subgroups, based on the ratio of solvent power to critical solvent power; for each of the subgroups, determining the threshold light paraffin content, said threshold light paraffin content being the light paraffin content of the hydrocarbon fluids at the point at which the fouling tendency of the hydrocarbon fluids exceeds a fouling threshold; and determining a relationship between the ratio of solvent power to critical solvent power and the threshold light paraffin content.
    Type: Grant
    Filed: August 17, 2016
    Date of Patent: July 9, 2019
    Assignee: BP Corporation North America Inc.
    Inventors: Soban Balashanmugam, Ronald Fisher, Devin Halliday
  • Patent number: 10329454
    Abstract: The present invention relates to a composition comprising a silane modified metal oxide, wherein the silane modified metal oxide comprises a metal oxide having attached at least one silyl group, and wherein the silyl group comprises at least one —SO3?M+, —OSO3?M+, —SSO3?M+, —NHSO3?M+, —NR?SO3?M+, —NR?3+A?, or -Q+A? group. R?, which can be the same or different, is a branched or unbranched, substituted or unsubstituted alkyl, alkenyl or alkynyl group or a substituted or unsubstituted aryl, heteroaryl, alkylaryl; or arylalkyl group, M+ is a cationic counterion, and A? is a anionic counterion. The present invention further relates to the silane modified metal oxide used in the disclosed chemical mechanical polishing composition.
    Type: Grant
    Filed: June 16, 2016
    Date of Patent: June 25, 2019
    Assignee: Cabot Corporation
    Inventor: James A. Belmont
  • Patent number: 10274465
    Abstract: The invention provides an apparatus for polymer chromatography, comprising at least one column that comprises a first stationary phase comprising one of the following: A) a material comprising at least one non-carbon atom, excluding glass or a metal, selected from molybdenum sulfide MoS2, tungsten sulfide WS2, silicon carbide SiC, boron nitride BN, or combinations thereof, or B) glass, or a metal, or combinations thereof, and a material comprising at least one non-carbon atom selected from molybdenum sulfide MoS2, tungsten sulfide WS2, silicon carbide SiC, boron nitride BN, or combinations thereof. The invention also provides a method for polymer chromatography, comprising introducing a solution, comprising a polymer, into a liquid flowing through a first stationary phase, and wherein the first stationary phase comprises one of foregoing materials (A) or (B).
    Type: Grant
    Filed: June 1, 2012
    Date of Patent: April 30, 2019
    Assignee: Dow Global Technologies LLC
    Inventors: Rongjuan Cong, Charles M. Cheatham, Al Parrott, Wallace W. Yau, Lonnie G. Hazlitt, Zhe Zhou, Alexander W. Degroot, Matthew D. Miller
  • Patent number: 10246472
    Abstract: Guanidine-functionalized particles and methods of making and using such particles.
    Type: Grant
    Filed: April 17, 2017
    Date of Patent: April 2, 2019
    Assignee: 3M Innovative Properties Company
    Inventors: George W. Griesgraber, Robert T. Fitzsimons, Jr., Douglas A. Hanggi, Masayuki Nakamura, Jerald K. Rasmussen
  • Patent number: 10247715
    Abstract: A sensor for detecting an analyte in a liquid. The sensor includes an antenna, covered with a layer of a molecularly imprinted polymer capable of interacting with an analyte and inducing a variation in the characteristics of the antenna within the microwave frequency range.
    Type: Grant
    Filed: June 25, 2015
    Date of Patent: April 2, 2019
    Assignees: Universite De Bourgogne, Institut National Superieur Des Sciences Agronomiques De L'alimentation Et De L'environnement
    Inventors: Jerome Rossignol, Elias Bou-Maroun, Celine Lafarge, Didier Stuerga, Philippe Cayot
  • Patent number: 10244582
    Abstract: A heater element having an electrically insulating substrate, a buss layer made of a conductive material, and a resistive layer that includes a first patch of a first resistive material. The first buss layer has a first buss and a second buss extending from terminals of the heater element to a heating area of the heater element. The first resistive material is applied in a first selected location in the heating area so as to provide electrical communication between the first buss and the second buss and to enable an electrical current to flow through the first resistive material. The resistive layer includes a second patch of a second resistive material. The second patch is applied in a second selected location in the heating area so as to provide electrical communication between the first buss and the second buss, the second selected location being different from the first selected location.
    Type: Grant
    Filed: October 22, 2015
    Date of Patent: March 26, 2019
    Assignee: IEE INTERNATIONAL ELECTRONICS & ENGINEERING S.A.
    Inventor: Pino Giuseppe Carenza
  • Patent number: 10215740
    Abstract: The present invention relates to a method for manufacturing a chromatography column, in particular for a gas phase chromatography, comprising a stationary phase made from a sol. This method comprises the following steps: (a) introducing this sol at the first end of the column, (b) moving said sol towards the second end of the column, so that a sol layer is formed on the internal wall of the column, this layer being able to form a gel on said internal wall, and (c) drying of the gel. The present invention also relates to a capillary column as well as to a microcolumn which may be manufactured according to this method.
    Type: Grant
    Filed: July 28, 2014
    Date of Patent: February 26, 2019
    Assignees: Commissariat à l'énergie atomique et aux énergies alternatives, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFQUE, UNIVERSITE Claude Bernard LYON 1, CPE Lyon FCR
    Inventors: David Lefebvre, Bernadette Charleux, Florence Ricoul, Chloe Thieuleux
  • Patent number: 10209217
    Abstract: Devices and methods for characterization of analyte mixtures are provided. Some methods described herein include performing enrichment steps on a device before expelling enriched analyte fractions from the device for subsequent analysis. Also included are devices for performing these enrichment steps.
    Type: Grant
    Filed: September 19, 2017
    Date of Patent: February 19, 2019
    Assignee: Intabio, Inc.
    Inventor: Erik Gentalen
  • Patent number: 10207229
    Abstract: The disclosure relates to a process and related article for functionalizing a porous membrane by contacting the membrane with a polyacid polymer at low pH to stably adsorb a polyacid layer on the membrane pore surface. The resulting functionalized membrane is characterized by a high density of free acid groups, resulting in a higher specific capacity for its intended application. The process allows functionalization of porous membranes in a very simple, one-step process. Such functional membranes may find multiple uses, including rapid, selective binding of proteins for their purification or immobilization.
    Type: Grant
    Filed: August 30, 2016
    Date of Patent: February 19, 2019
    Assignee: BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY
    Inventors: Merlin L. Bruening, Gregory L. Baker, Somnath Bhattacharjee, Yiding Ma
  • Patent number: 10175217
    Abstract: A method for recovering a metal, capable of suppressing variations in complex recovery yields among samples is described, wherein the method comprises: forming a complex between a metal in a sample and a chelating agent for metal in a mixture containing the sample and the chelating agent; and filtering the mixture in the presence of an inorganic salt to recover the complex, thereby recovering the metal in the sample.
    Type: Grant
    Filed: February 26, 2015
    Date of Patent: January 8, 2019
    Assignee: ARKRAY, Inc.
    Inventor: Akitsugu Kudo
  • Patent number: 10159911
    Abstract: The present invention provides novel chromatographic materials, e.g., for chromatographic separations, processes for its preparation and separations devices containing the chromatographic material; separations devices, chromatographic columns and kits comprising the same; and methods for the preparation thereof. The chromatographic materials of the invention are high purity chromatographic materials comprising a chromatographic surface wherein the chromatographic surface comprises a hydrophobic surface group and one or more ionizable modifier.
    Type: Grant
    Filed: January 25, 2013
    Date of Patent: December 25, 2018
    Assignee: Waters Technologies Corporation
    Inventors: Kevin Daniel Wyndham, Pamela C. Iraneta, Thomas H. Walter
  • Patent number: 10155177
    Abstract: A liquid-chromatography module includes a microfluidic cartridge housing a microfluidic substrate with a channel for transporting fluid. The microfluidic substrate has fluidic apertures through which fluid is supplied to the channel. One side of the cartridge has nozzle openings, each aligning with a fluidic aperture in the microfluidic substrate and receiving a fluidic nozzle. A clamping assembly has a plunger that is movable into a clamped position and an end housing that defines a chamber. One wall of the end housing has a fluidic block with fluidic nozzles extending into the chamber. A second wall has a slot through which the cartridge enters the chamber. When moved into the clamped position while the cartridge is in the chamber, the plunger urges the cartridge against the fluidic block such that each fluidic nozzle enters one nozzle opening and establishes fluidic communication with one fluidic aperture in the microfluidic substrate.
    Type: Grant
    Filed: June 23, 2015
    Date of Patent: December 18, 2018
    Assignee: WATERS TECHNOLOGIES CORPORATION
    Inventors: David P. Prentice, Russell L. Keene, Stanislaw Koziol, Joseph D. Michienzi, Paul E. Linderson, Gary W. Bertone
  • Patent number: 10145835
    Abstract: The present invention relates to a system of analysis, which can be used in a mobile laboratory in a drilling site situation or in a similar situation, suitable for measuring (preferably in relation to at least two partially gaseous species, which derive preferably from a mixture extracted from a drilling mud, for example, methane, ethane, propane and/or any other heavier hydrocarbons) the quantities of the different isotopes of at least a same chemical element (preferably the quantities of 13C, carbon isotope with 6 protons and 7 neutrons, and of 12C, carbon isotope with 6 protons and 6 neutrons, respectively) by means of a laser isotopes analyzer regulated for a single, at least partially gaseous species which contains said chemical element.
    Type: Grant
    Filed: August 15, 2016
    Date of Patent: December 4, 2018
    Assignee: GEOLOG S.R.L.
    Inventor: Antonio Calleri
  • Patent number: 10093919
    Abstract: Methods for automated extraction of nucleic acids are disclosed. Also disclosed are method and kits for isolating fetal nucleic acids from a plasma sample of a pregnant woman. The method includes flowing the plasma sample through a first filter under conditions that allow binding of the fetal and maternal nucleic acids to the first filter; eluting the fetal and maternal nucleic acids bound to the first filter to produce a concentrated nucleic acid sample; flowing the concentrated nucleic acid sample through a second filter under conditions that allow preferential binding of the maternal nucleic acids to the second filter; and recovering the fetal nucleic acid from the concentrated nucleic acid sample that flow through the second filter.
    Type: Grant
    Filed: July 20, 2016
    Date of Patent: October 9, 2018
    Assignee: Akonni Biosystems, Inc.
    Inventors: Rebecca Holmberg, Alissa Erin Burkey, Tinsley Janna Stokes, Phillip Belgrader