Blood Patents (Class 210/782)
  • Patent number: 10585085
    Abstract: Embodiments are described for separating/collecting components from a multi-component fluid such as whole blood. Some embodiments provide for controlling the amount of a component, such as platelets, introduced into a separation chamber to ensure that the density of fluid in the separation chamber does not exceed a particular value. This may provide for collecting purer components. Other embodiments may provide for determining a chamber flow rate based on a concentration of a component in the multi-component fluid, which may then be used to determine a centrifuge speed, to collect purer concentrated components.
    Type: Grant
    Filed: October 13, 2017
    Date of Patent: March 10, 2020
    Assignee: Terumo BCT, Inc.
    Inventors: Marlene Bainbridge, Todd Curtis Green, Logan Fender
  • Patent number: 10576473
    Abstract: An assembly for mitigating spillage of patient sample in a patient sample tube having an open top includes a patient sample in the tube and a layer of inert material floating on the sample fluid, such that the material restricts splashing movement of the sample's surface. The material can include a foam, a gel, or a disk. The disk can be approximately the diameter of the sample tube with a center opening configured to accept a pipette to provide access to the patient sample.
    Type: Grant
    Filed: August 25, 2016
    Date of Patent: March 3, 2020
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Keld Sorensen, Baris Yagci, Robert Hempton
  • Patent number: 10254292
    Abstract: Methods are provided for estimating the relative amounts of identifiable compartments, such as different types of cells or cell components, within a biological sample. The methods use mass spectrometric analysis to quantitate compartment-specific molecules and thereby allow calculation of the amount of each compartment that is present in a biological sample. The methods can, for example, provide a measurement of hematocrit from a dried blood sample.
    Type: Grant
    Filed: March 6, 2017
    Date of Patent: April 9, 2019
    Assignee: SISCAPA ASSAY TECHNOLOGIES, INVC.
    Inventor: N. Leigh Anderson
  • Patent number: 9909977
    Abstract: The present invention relates to a method for determining both (a) the haematocrit value and (b) the fibrinogen content in whole blood of an individual in less than 5 minutes, as well as to associated portable apparatus.
    Type: Grant
    Filed: October 15, 2014
    Date of Patent: March 6, 2018
    Assignees: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICAL, ETAT FRANCAIS (MINISTERE DE LA DEFENSE), SERVICE DE SANTE DES ARMEES, ASSITANCE PUBLIQUE—HOPITAUX DE PARIS, UNIVERSITE PARIS DECARTES
    Inventors: Pascale Gaussem, Anne Godier, Isabelle Gouin-Thibault, Bernard Le Bonniec, Anne-Celine Martin, Nyoucha Morravedge, Marc Samama
  • Patent number: 9878101
    Abstract: A package including a vessel made of cyclic olefin polymer (COP) resin, a CVD coating on a vessel, and a medicament comprising at least one protein, peptide, and/or DNA sequence is disclosed. Methods for processing a vessel, for example to provide lubricity or hydrophobicity, are also disclosed. The interior surface of the seated vessel can be processed via the vessel port by PECVD. Vessel barrier, lubricity and hydrophobic coatings and coated vessels, for example syringes and medical sample collection tubes are disclosed.
    Type: Grant
    Filed: September 22, 2011
    Date of Patent: January 30, 2018
    Assignee: SIO2 MEDICAL PRODUCTS, INC.
    Inventors: John T. Felts, Thomas E. Fisk, Robert S. Abrams, John Ferguson, Jonathan R. Freedman, Robert J. Pangborn, Peter J. Sagona
  • Patent number: 9849222
    Abstract: Method and Apparatus for predicting the volume of a component separated from a composite fluid by predicting the volume of the composite fluid from sensed pressure and predicting the volume of other separated components from sensed movement of the other components to collection bags.
    Type: Grant
    Filed: May 11, 2015
    Date of Patent: December 26, 2017
    Assignee: Terumo BCT, Inc.
    Inventors: Victor D. Dolecek, Darryl Hudock
  • Patent number: 9649424
    Abstract: The present invention relates to a separation system and a separation material for easily and rapidly separating a red blood cell-rich fraction, a white blood cell-rich fraction, and/or a platelet-rich fraction from a biological fluid containing these blood cell components without the necessity of performing centrifugation. The separation of a red blood cell-rich fraction, a white blood cell-rich fraction, and/or a platelet-rich fraction from a biological fluid can be accomplished by capturing white blood cells and platelets on a blood cell separation material by contacting the biological fluid with the blood cell separation material, thereby providing a red blood cell-rich fraction; and recovering a white blood cell-rich fraction by separating white blood cells captured from the resulting blood cell separation material using a separation solution.
    Type: Grant
    Filed: June 28, 2010
    Date of Patent: May 16, 2017
    Assignee: KANEKA CORPORATION
    Inventors: Nobuhiko Sato, Shinya Yoshida, Akira Kobayashi, Masaru Nakatani
  • Patent number: 9603986
    Abstract: A system and method are provided, including an integrated single-use kit, for processing whole blood to produce platelet rich plasma. A two stage spinning membrane separator, has a first stage for receiving whole blood and separating substantially all red blood cells from plasma and platelets, and a second stage for further separating platelet rich plasma from plasma. A first waste container is in fluid communication with the first stage of the separator for receiving separated red blood cells, while a second waste container is in fluid communication with the second stage of the separator for receiving separated plasma. An outlet line is in fluid communication with the second stage of the separator for receiving platelet rich plasma, and a reinfusion container is removably connected to the outlet line for receiving platelet rich plasma from the second stage of the separator.
    Type: Grant
    Filed: August 30, 2013
    Date of Patent: March 28, 2017
    Assignee: Fenwal, Inc.
    Inventors: Benjamin E. Kusters, Christopher J. Wegener, Kyungyoon Min
  • Patent number: 9421328
    Abstract: The present invention relates to a clot trap that comprises a disc-shaped screen surface for collecting clots in a fluid flowing through the screen surface. It further relates to an external blood cassette and a blood circuit, as well as a treatment apparatus.
    Type: Grant
    Filed: April 22, 2010
    Date of Patent: August 23, 2016
    Assignee: Fresenius Medical Care Deutschland GmbH
    Inventors: Christoph Brueckner, Martin Lauer, Manfred Weis
  • Patent number: 9365815
    Abstract: Provided are a particle separation device and a method of separating particles, each of which can easily separate particles for a short time without a great stress to the particles and easily collect the particles thus separated. The particle separation device includes at least: a separation flow path (i) to which a separation fluid and a particle group including two types of particles being different in density are supplied, and (ii) through which the separation fluid flows in a certain direction; a divergence section connected to at least an end of the separation flow path in the certain direction in which the separation fluid flows, a first flow path formed from the divergence section in a rising direction; and a second flow path formed from the divergence section in a falling direction, the separation flow path being formed in a horizontal direction.
    Type: Grant
    Filed: August 19, 2013
    Date of Patent: June 14, 2016
    Assignee: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY
    Inventors: Masaya Miyazaki, Daisuke Sugiyama, Kenichi Yamashita, Yuuki Teshima, Hiroyuki Nakamura, Hideaki Maeda
  • Patent number: 9168528
    Abstract: A biological fluid collection cup for use with a centrifuge bucket to separate a biological fluid into its component parts is disclosed. It includes an hourglass shape with a large upper and lower portion and a narrow middle portion. A piston is to slide into and slideably be received in the lower portion and a side port is provided for withdrawal of a fluid from the narrow portion.
    Type: Grant
    Filed: April 1, 2014
    Date of Patent: October 27, 2015
    Assignee: Alliance Partners, LLC
    Inventors: Emad Hassouneh, Logan White, Matt Schmidt, Frank Morris, Andrew Enke
  • Patent number: 8992403
    Abstract: A cartridge (1) for accommodating blood bags (35) to be inserted into a centrifuge is used for the separation of blood components. Said cartridge (1) is provided with a partition wall (3) which separates a blood bag section (5) positioned radially inside from a product section (7) positioned radially outside, wherein a fixture (29) for a filter (31) is provided in the product section (7), a product transport path (36) which leads from the blood bag section (5) via the fixture (29) for the filter (31) to the product section (7). The product transport path (36) coming from the blood bag section (5) leads into the fixture (29) for the filter (31) radially from the outside and from below.
    Type: Grant
    Filed: June 4, 2008
    Date of Patent: March 31, 2015
    Assignees: Terumo BCT, Inc., Andreas Hettich GmbH & Co. KG
    Inventors: Klaus-Günter Eberle, Roland Biset
  • Patent number: 8961445
    Abstract: This invention provides an apparatus and methods to consistently separate and concentrate selected blood components. The system includes, e.g., a computerized fluid handling system to transfer blood components between a centrifugal blood separation disc, containers and a concentrator.
    Type: Grant
    Filed: January 10, 2013
    Date of Patent: February 24, 2015
    Assignee: Biomet Biologics, LLC
    Inventors: Douglas M. Arm, Michael Ponticiello, Surinder Mathur, Andrew G. Hood
  • Patent number: 8936162
    Abstract: Methods of producing collection tubes are presented. The methods include providing a separator substance that can rapidly polymerize in a short time to a desired hardness and disposing the separator substance within the lumen of the tube. The separator substance is formulated to have a density between an average density of a serum fraction of whole blood and a cell-containing fraction of whole blood, and to be flowable with whole blood. Upon centrifugation of a tube having blood, the separator substance forms a barrier between the whole blood fractions. The tube and barrier maintain stability of one or more analyte levels, including potassium and glucose, within 10% of their initial values before centrifugation for at least four days.
    Type: Grant
    Filed: July 1, 2011
    Date of Patent: January 20, 2015
    Assignee: The Regents of the University of California
    Inventor: Jane Emerson
  • Patent number: 8871100
    Abstract: Processing of a bulk liquid including particles, including use of a rotating strainer surface with openings disposed on a circumference thereof, the openings allowing an extracted liquid in the bulk liquid to pass through the strainer surface while preventing particles from passing through the strainer surface, such that a concentration of particles in the extracted liquid is less than in the bulk liquid; an extracted liquid outflow port which outputs the extracted liquid from an interior region of the rotating strainer surface; and a motor configured to rotate the strainer surface at a speed sufficient to generate a centrifugal force or turbulence at the openings sufficient to prevent the particles from clogging the openings, wherein the strainer surface is rotated and the extracted liquid is output through the extracted liquid outflow port when the strainer surface is fully submerged in the bulk liquid.
    Type: Grant
    Filed: December 30, 2011
    Date of Patent: October 28, 2014
    Assignee: SPX APV Denmark A/S
    Inventors: Michael Franklin Jørgensen, Klaus Pedersen
  • Patent number: 8808551
    Abstract: An apparatus that allows for separating and collecting a fraction of a sample. The apparatus, when used with a centrifuge, allows for the creation of at least three fractions in the apparatus. It also provides for a new method of extracting the buffy coat phase from a whole blood sample and mesenchymal stem cells from bone reaming material. A buoy system that may include a first buoy portion and a second buoy member operably interconnected may be used to form at least three fractions from a sample during a substantially single centrifugation process. Therefore, the separation of various fractions may be substantially quick and efficient.
    Type: Grant
    Filed: November 15, 2010
    Date of Patent: August 19, 2014
    Assignee: Biomet Biologics, LLC
    Inventors: Michael D. Leach, Joel C. Higgins, Matthew Swift, Nathan Gordon
  • Patent number: 8802362
    Abstract: Methods and devices for preparing a solid-fibrin web are provided. One method may include drawing blood from a patient, separating plasma from the blood, contacting the plasma with a calcium-coagulation activator and concurrently coagulating and axially centrifuging the plasma to form the solid-fibrin web. The solid-fibrin web may be suitable for regenerating body tissue in a living organism. Devices used in the methods may also be provided.
    Type: Grant
    Filed: May 18, 2010
    Date of Patent: August 12, 2014
    Assignee: Cascade Medical Enterprises, LLC
    Inventors: Nicholas A. Grippi, Roberto C. Beretta
  • Patent number: 8763816
    Abstract: A filter for processing blood that comprises a flexible container having an inlet and an outlet for blood, and a sheet-like blood processing filter material situated in such a manner so as to partition the inside of the container into an inlet side and an outlet side, wherein the flexible container comprises a container body which houses the blood processing filter material and an outlet port that forms the outlet, and the outlet port has a protrusion that protrudes from the container body into the inside of the container body, the protrusion having a plurality of fluid channel inlets formed at locations that are not in contact with the blood processing filter material.
    Type: Grant
    Filed: March 29, 2011
    Date of Patent: July 1, 2014
    Assignee: Asahi Kasei Medical Co., Ltd.
    Inventors: Michiyo Andou, Tomohisa Yokomizo
  • Patent number: 8747781
    Abstract: A mechanical separator for separating a fluid sample into first and second phases is disclosed. The mechanical separator includes a float, a ballast assembly longitudinally moveable with respect to the float, and a bellows structure. The bellows structure includes a first end, a second end, and a deformable bellows therebetween. The float is attached to a portion of the first end of the bellows structure, and the ballast is attached to a portion of the second end of the bellows structure. The attached float and bellows structure includes a releaseable interference engagement therebetween. The float has a first density, and the ballast has a second density that is greater than the first density of the float.
    Type: Grant
    Filed: July 21, 2009
    Date of Patent: June 10, 2014
    Assignee: Becton, Dickinson and Company
    Inventors: Benjamin Bartfeld, Jamieson W. Crawford, Robert G. Ellis, Christopher A. Battles, Kenneth Handeland
  • Patent number: 8696905
    Abstract: A concentrator is used for concentrating a fluid, particularly a plasma component out of blood, for treatment of a patient. The concentrator apparatus includes a main housing defining a centrifuge chamber, that also holds the filter. The concentrator allows viewing of the fluid after centrifuging, with an outlet port positionable at a height corresponding to the level of the fraction of the fluid to be further concentrated. Once the fluid is centrifuged, a portion of the fluid is drawn through the outlet, and then pressured past the filter to further concentrate the fluid using the same vessel as used for centrifuging. The same plunger is preferably used to draw centrifuged fluid from the centrifuge chamber as to pressure the centrifuged fluid past the filter.
    Type: Grant
    Filed: August 26, 2011
    Date of Patent: April 15, 2014
    Assignee: Circle Biologics, Inc.
    Inventors: Thomas Coull, Matthew R. Kyle, Louis S. Kidder
  • Patent number: 8685258
    Abstract: Systems and methods are provided for conveying an amount of red blood cells and an amount of plasma to a blood source. Blood is conveyed from a blood source into a separation device and the separation device is operated to separate the blood into a layer containing red blood cells and a layer containing plasma. Red blood cells and plasma are removed from the separation device and volumes of the red blood cells and plasma are conveyed to the blood source. The volumes of red blood cells and plasma are alternately conveyed to the blood source for said amounts of red blood cells and plasma.
    Type: Grant
    Filed: February 27, 2009
    Date of Patent: April 1, 2014
    Assignee: Fenwal, Inc.
    Inventors: Lan T. Nguyen, Kyungyoon Min, Tony Nguyen
  • Patent number: 8623655
    Abstract: The invention provides a serum or plasma separating composition which can compensate for the lack of initial thixotropy even at a reduced inorganic powder concentration and in which crevices or the like are less likely to be created in a partition wall formed of the separating composition after being centrifuged. The serum or plasma separating composition contains a liquid resin component having a partition wall-forming capability, a hydrophilic inorganic powder, a hydrophobic inorganic powder, and an organic compound serving as a thixotropy enhancer, wherein the organic compound is a polyalkylene glycol and/or a derivative thereof and is made of at least one type of polymer.
    Type: Grant
    Filed: January 25, 2011
    Date of Patent: January 7, 2014
    Assignee: Sekisui Medical Co., Ltd.
    Inventors: Hideo Anraku, Masatoshi Niunoya
  • Patent number: 8607989
    Abstract: A filter and a method of forming a suture structure. The filter includes layered structure(s) interior to the filter. Each layered structure includes a carbon structure comprising carbon and a coating on a surface of the carbon structure. Each layered structure may further include a heparin layer that includes heparin and is on the coating. The coating of the filter includes cellulose, PMMA, PEMA, or PHEMA. The carbon structure may include an activated charcoal layer or carbon nanotube(s). The layered structure is configured to remove a contaminant flowing through the filter. The method of forming the suture structure includes forming a film on a suture that has been previously formed on a mammal. The film includes both a coating on the suture and a heparin layer that includes heparin and is on the coating. The coating of the suture structure includes cellulose, PMMA, PEMA, or PHEMA.
    Type: Grant
    Filed: June 15, 2010
    Date of Patent: December 17, 2013
    Assignee: Vascular Vision Pharmaceutical Co.
    Inventors: Shaker A. Mousa, Robert J. Linhardt
  • Patent number: 8580183
    Abstract: Methods of producing collection tubes are presented. The methods include providing a separator substance that can rapidly polymerize in a short time to a desired hardness and disposing the separator substance within the lumen of the tube. The separator substance is formulated to have a density between an average density of a serum fraction of whole blood and a cell-containing fraction of whole blood, and to be flowable with whole blood. Upon centrifugation of a tube having blood, the separator substance forms a barrier between the whole blood fractions. The barrier rapidly hardens forming a solid barrier when triggered by a suitable energy source.
    Type: Grant
    Filed: November 19, 2012
    Date of Patent: November 12, 2013
    Assignee: The Regents of the University of California
    Inventor: Jane F. Emerson
  • Patent number: 8567609
    Abstract: An apparatus that allows for separating and collecting a fraction of a sample. The apparatus, when used with a centrifuge, allows for the creation of at various fractions in the apparatus. A buoy system that may include a first buoy portion and a second buoy member operably interconnected may be used to form at least three fractions from a sample during a substantially single centrifugation process. Therefore, the separation of various fractions may be substantially quick and efficient. Also selected fractions from the sample can be applied to a patient, either alone or as part of a mixture.
    Type: Grant
    Filed: April 19, 2011
    Date of Patent: October 29, 2013
    Assignee: Biomet Biologics, LLC
    Inventors: Matthew D. Landrigan, Michael D. Leach, Joel C. Higgins
  • Patent number: 8540657
    Abstract: Methods of and apparatuses for equine plasma collection are provided. Modified plasmapheresis instruments and modified disposable plasmapheresis tubing are introduced. By using the modified procedures and instruments, a high-speed, high volume, continuous-flow process of automated equine plasmapheresis is developed. The modified closed systems remove whole blood from the donor horses, separate plasma from the cellular components of blood, and simultaneously returning concentrated cells back to the donor horses.
    Type: Grant
    Filed: November 6, 2009
    Date of Patent: September 24, 2013
    Assignee: Auburn University
    Inventors: Kenny V. Brock, Sara Ziska
  • Patent number: 8535210
    Abstract: A centrifugal blood separation system comprising a rotor, a light source, an optical sensor, a control system, a separation vessel, and an optical cell on the separation vessel. The optical cell has a first extraction port extending radially outwardly into the optical cell, a red blood cell extraction port downstream from the first extraction port and extending into the optical cell beyond the first extraction port; and a dam between said first extraction port and said red blood cell extraction port, having an upper edge and a lower edge, wherein the first extraction port and the red cell extraction port are radially between the upper edge and the lower edge of the dam. Also, a first extraction port having a bore having a first diameter, a lumen having a second diameter smaller than the first diameter, and a frustro-conical passageway coupling the bore to the lumen.
    Type: Grant
    Filed: December 3, 2010
    Date of Patent: September 17, 2013
    Assignee: Terumo BCT, Inc.
    Inventors: Jeremy P. Kolenbrander, Brian M. Holmes, Thomas J. Felt, James R. Ladtkow
  • Patent number: 8511480
    Abstract: A device for separating and isolating components of a biological fluid comprising a container for containing the fluid to be processed, a tube cap assembly for closing the container while providing filling and extraction communication therewith, a float assembly disposed within the container for funneling and controlling biological fluid flow into an inverted domed shaped isolation chamber within the float and controlling the biological fluid flow out of the isolation chamber for effecting an encapsulation or a sealed isolation of at least one component or fraction of the biological fluid flow within the isolation chamber during a centrifugation process. The device further comprising a flexible tube for connecting an extraction passageway disposed within the float assembly and an extraction valve of the tube cap assembly for allowing extraction of at least the one component or fraction encapsulated or isolated within the chamber.
    Type: Grant
    Filed: March 30, 2012
    Date of Patent: August 20, 2013
    Assignee: ThermoGenesis Corp.
    Inventors: John R. Chapman, Vijay Kumar, Brian K. Cinquini, Phillip D. Kingsley
  • Patent number: 8511479
    Abstract: A device for separating and isolating components of a biological fluid comprising a container for containing the fluid to be processed, a tube cap assembly for closing the container while providing filling and extraction communication therewith, a float assembly disposed within the container for funneling and controlling biological fluid flow into an inverted domed shaped isolation chamber within the float and controlling the biological fluid flow out of the isolation chamber for effecting an encapsulation or a sealed isolation of at least one component or fraction of the biological fluid flow within the isolation chamber during a centrifugation process. The device further comprising a flexible tube for connecting an extraction passageway disposed within the float assembly and an extraction valve of the tube cap assembly for allowing extraction of at least the one component or fraction encapsulated or isolated within the chamber.
    Type: Grant
    Filed: January 24, 2012
    Date of Patent: August 20, 2013
    Assignee: ThermoGenesis Corp.
    Inventors: John R. Chapman, Vijay Kumar, Brian K. Cinquini, Phillip D. Kingsley
  • Patent number: 8512575
    Abstract: A method and apparatus can separate and concentrate a selected component from a multi-component material. The multi-component material may include a whole sample such as adipose tissue, whole blood, or the like. The apparatus generally includes a moveable piston positioned within a separation container and a withdrawal tube that is operable to interact with a distal end of the collection container past the piston. Material can be withdrawn through the withdrawal tube.
    Type: Grant
    Filed: August 6, 2012
    Date of Patent: August 20, 2013
    Assignee: Biomet Biologics, LLC
    Inventors: Michael D. Leach, James M. McKale
  • Patent number: 8506823
    Abstract: A device for separating and isolating components of a biological fluid comprising a container for containing the fluid to be processed, a tube cap assembly for closing the container while providing filling and extraction communication therewith, a float assembly disposed within the container for funneling and controlling biological fluid flow into an inverted domed shaped isolation chamber within the float and controlling the biological fluid flow out of the isolation chamber for effecting an encapsulation or a sealed isolation of at least one component or fraction of the biological fluid flow within the isolation chamber during a centrifugation process. The device further comprising a flexible tube for connecting an extraction passageway disposed within the float assembly and an extraction valve of the tube cap assembly for allowing extraction of at least the one component or fraction encapsulated or isolated within the chamber.
    Type: Grant
    Filed: January 26, 2012
    Date of Patent: August 13, 2013
    Assignee: ThermoGenesis Corp.
    Inventors: John R. Chapman, Vijay Kumar, Brian K. Cinquini, Phillip D. Kingsley
  • Patent number: 8506825
    Abstract: A method of washing blood mixed with undesirable elements not normally found in healthy whole blood to remove the undesirable elements, the method comprising: separating the blood into components according to relative densities of the components with a rotating centrifuge bowl; providing a port through which fluid exits the bowl, the exiting fluid having a concentration of undesirable elements; flowing washing solution into the centrifuge bowl at an initial flow rate; monitoring the fluid exiting the bowl with an optical sensor having an output signal indicative of the composition of the exiting fluid; and increasing and decreasing the flow rate of the wash solution as a function of the output signal.
    Type: Grant
    Filed: November 27, 2006
    Date of Patent: August 13, 2013
    Assignee: Sorin Group Italia S.r.l.
    Inventors: Matteo Fortini, Stefano Reggiani, Ivo Panzani
  • Patent number: 8496833
    Abstract: A method of removing leukocytes that through reducing of clogging of a leukocyte removing filter element by blood cell components and plasma proteins being a problem encountered at the time of removing leukocytes from blood, shortens the filtration time at refrigerated filtration and exhibits high leukocyte removing performance at room temperature filtration. There is provided a method of removing leukocytes including filtering blood containing leukocytes through a leukocyte removing filter apparatus having multiple fibrous filter elements with different average fiber diameters to thereby remove leukocytes from the blood, characterized in that use is made of a leukocyte removing filter apparatus wherein the multiple fibrous filter elements include at least leukocyte removing filter element (A) of 2.0 to <4.0 ?m average fiber diameter and leukocyte removing filter element (B) of 0.7 to 1.
    Type: Grant
    Filed: December 28, 2005
    Date of Patent: July 30, 2013
    Assignee: Asahi Kasei Medical Co., Ltd.
    Inventor: Kenji Kobayashi
  • Patent number: 8480606
    Abstract: A system is disclosed for removing gas bubbles from blood during circulatory assist procedures. Such bubbles are generated, along with particulate matter, in an extracorporeal circulatory bypass system by the pump, oxygenator and other components. Current filters are inefficient at removing small bubbles that can cause neurological defects and renal and other organ failures in the patient. An active filter apparatus and method is disclosed that forces the bubbles to the center of the system where they are removed from the blood before the blood exits the filter. The filter comprises an axially elongate cylindrical shell with a blood inlet, a blood outlet and a gas outlet. A motor driven impeller spins the blood within the shell and forces the gas toward the center by centripetal force, utilizing the buoyancy effects of the bubbles in blood, whereby the bubbles can be bled off at the center of the filter.
    Type: Grant
    Filed: November 2, 2010
    Date of Patent: July 9, 2013
    Assignee: Indian Wells Medical, Inc.
    Inventors: David W. Wieting, Jay A. Lenker
  • Patent number: 8469202
    Abstract: A centrifugal processing bag, system and method for separating the components of a mixed material is presented. The processing bag includes a hub and a first port for receiving the mixed material, where the first port includes an outlet positioned within the processing bag at a perimeter of the bag. The processing bag also including a second port having a second port inlet spaced proximate the hub and away from a central axis of the hub. The second port directs a separated material collected from the second port inlet out of the processing bag.
    Type: Grant
    Filed: November 1, 2010
    Date of Patent: June 25, 2013
    Assignee: Velico Medical, Inc.
    Inventor: Keith M. Rosiello
  • Patent number: 8449439
    Abstract: A centrifuge for separating blood having a camera observing fluid flow, and a controller controlling the flow. The location of an interface is detected by image processing steps, which may comprise the steps of “spoiling” the image, “diffusing” the image, “edge detection”, “edge linking”, “region-based confirmation”, and “interface calculation”. “Spoiling” reduces the number of pixels to be examined preferentially on orthogonal axis oriented with respect to the expected location of the interface or phase boundary. “Diffusing” smoothes out small oscillations in the interface boundary, making to the location of the interface more distinct. “Edge detection” computes the rate of change in pixel intensity. “Edge linking” connects adjacent maxima. “Region-based confirmation” creates a pseudo image of the regions that qualify as distinct. “Final edge calculation” uses the points where the shade changes in the pseudo image, averages the radial displacement of these points for the interface position.
    Type: Grant
    Filed: November 16, 2012
    Date of Patent: May 28, 2013
    Assignee: Terumo BCT, Inc.
    Inventors: Christopher Fletcher, William Sweat, Jeremy P. Kolenbrander, Aditya Dalvi, John R. Lindner
  • Patent number: 8415169
    Abstract: A tube and float system for use in separation and axial expansion of the buffy coat includes a transparent or semi-transparent, flexible sample tube and a rigid separator float having a specific gravity intermediate that of red blood cells and plasma. The float includes a main body portion of reduced diameter to provide a clearance gap between the inner wall of the sample tube and the float. One or more protrusions on the main body portion serve to support the flexible tube. During centrifugation, the centrifugal force causes the diameter of the flexible tube to expand and permit density-based axial movement of the float in the tube. The float further includes a pressure relief system to alleviate pressure build up in the trapped red blood cell blood fraction below the float, thereby preventing red blood cells from being forced into the annular gap containing the buffy coat layers.
    Type: Grant
    Filed: February 13, 2012
    Date of Patent: April 9, 2013
    Assignee: Battelle Memorial Institute
    Inventors: Thomas Haubert, Vince Contini, Steve Grimes, Randy Jones, Stephen C. Wardlaw
  • Patent number: 8409447
    Abstract: A separation chip for separating an insoluble component from a suspension using centrifugal force by rotation, includes a suspension holding tank, a separation liquid holding tank, and an insoluble component holding tank arranged in order from an inner circumferential side during rotation, wherein the suspension holding tank and the insoluble component holding tank are connected to each other, the insoluble component holding tank and the separation liquid holding tank are connected to each other by a narrow portion, and in the insoluble component holding tank, a connecting portion with the suspension holding tank is positioned further toward an outer circumferential side than the narrow portion.
    Type: Grant
    Filed: January 27, 2009
    Date of Patent: April 2, 2013
    Assignee: Toray Industries, Inc.
    Inventors: Kentaro Ishii, Masashi Higasa, Shingo Hiramatsu
  • Patent number: 8361005
    Abstract: This invention provides an apparatus and methods to consistently separate and concentrate selected blood components. The system includes, e.g., a computerized fluid handling system to transfer blood components between a centrifugal blood separation disc, containers and a concentrator.
    Type: Grant
    Filed: September 2, 2010
    Date of Patent: January 29, 2013
    Assignee: Biomet Biologics, LLC
    Inventors: Douglas M. Arm, Michael Ponticiello, Surinder Mathur, Andrew G. Hood
  • Patent number: 8337379
    Abstract: A centrifuge for separating blood having a camera observing fluid flow, and a controller controlling the flow. The location of an interface is detected by image processing steps, which may comprise the steps of “spoiling” the image, “diffusing” the image, “edge detection”, “edge linking”, “region-based confirmation”, and “interface calculation”. “Spoiling” reduces the number of pixels to be examined preferentially on orthogonal axis oriented with respect to the expected location of the interface or phase boundary. “Diffusing” smoothes out small oscillations in the interface boundary, making the location of the interface more distinct. “Edge detection” computes the rate of change in pixel intensity, or. “Edge linking” connects adjacent maxima. “Region-based confirmation” creates a pseudo image of the regions that qualify as distinct. “Final edge calculation” uses the points where the shade changes in the pseudo image, averages the radial displacement of these points for the interface position.
    Type: Grant
    Filed: July 2, 2007
    Date of Patent: December 25, 2012
    Assignee: Terumo BCT, Inc.
    Inventors: Christopher Fletcher, William Sweat, Jeremy Kolenbrander, Aditya Dalvi, John R. Linder
  • Patent number: 8337711
    Abstract: Disclosed is a system to separate, enrich, and/or purify a cellular population from a biological tissue, such as a tissue sample. For example, an adipose tissue sample can be acquired and disrupted. The disrupted tissue sample can then be separated and purified. The separated components can include multipotent, pluripotent, or other cell populations.
    Type: Grant
    Filed: February 27, 2009
    Date of Patent: December 25, 2012
    Assignee: Biomet Biologics, LLC
    Inventors: Randel Dorian, Michael D. Leach, Richard W. Storrs, Jason Chavarria
  • Patent number: 8318077
    Abstract: Methods of producing collection tubes are presented. The methods include providing a separator substance that can rapidly polymerize in a short time to a desired hardness and disposing the separator substance within the lumen of the tube. The separator substance is formulated to have a density between an average density of a serum fraction of whole blood and a cell-containing fraction of whole blood, and to be flowable with whole blood. Upon centrifugation of a tube having blood, the separator substance forms a barrier between the whole blood fractions. The barrier rapidly hardens forming a solid barrier when triggered by a suitable energy source.
    Type: Grant
    Filed: May 29, 2012
    Date of Patent: November 27, 2012
    Assignee: The Regents of the University of California
    Inventor: Jane Emerson
  • Patent number: 8287742
    Abstract: Method for separating a volume of whole blood into at least a plasma component and a red blood cell component comprising centrifuging a separation bag containing a volume of whole blood so as to separate therein at least a first component comprising plasma and a second component comprising red blood cells; transferring the first component into a plasma component bag during centrifugation of the separation bag; transferring into the separation bag a volume of wash solution from a wash solution bag during centrifugation of the separation bag; mixing the volume of wash solution with the second component; centrifuging the separation bag so as to separate therein a washed red blood cell component and a supernatant component; and transferring the supernatant component into a waste bag during centrifugation of the separation bag.
    Type: Grant
    Filed: December 5, 2007
    Date of Patent: October 16, 2012
    Assignee: Terumo BCT, Inc.
    Inventor: Brian M. Holmes
  • Patent number: 8282540
    Abstract: Methods for using a centrifuge are presented. A vessel containing a sample and a separator substance is placed within a centrifuge. Upon sufficient centrifugation, the sample separates into two or more fractions separated by the separator substance. The centrifuge exposes the separator substance to a sufficient energy to polymerize the separator substance to produce a hardened barrier between the fractions.
    Type: Grant
    Filed: June 28, 2010
    Date of Patent: October 9, 2012
    Assignee: The Regents of the University of California
    Inventor: Jane Emerson
  • Patent number: 8236258
    Abstract: A method and apparatus can separate and concentrate a selected component from a multi-component material. The multi-component material may include a whole sample such as adipose tissue, whole blood, or the like. The apparatus generally includes a moveable piston positioned within a separation container and a withdrawal tube that is operable to interact with a distal end of the collection container past the piston. Material can be withdrawn through the withdrawal tube.
    Type: Grant
    Filed: October 31, 2011
    Date of Patent: August 7, 2012
    Assignee: Biomet Biologics, LLC
    Inventors: Michael D. Leach, James M. McKale
  • Patent number: 8236184
    Abstract: A method related to using a squeezing or transfer fluid to transfer fluid or components between bags in a centrifuge wherein the squeezing fluid can be reversed to reduce squeezing and such fluid an also be used to build up a over-pressure for rapid movement.
    Type: Grant
    Filed: October 31, 2007
    Date of Patent: August 7, 2012
    Assignee: Terumo BCT, Inc.
    Inventors: Brian M. Holmes, Peter Pihlstedt
  • Patent number: 8187475
    Abstract: A device for isolating a component of a multi-component composition. The device includes a housing, a chamber, and a withdrawal port. The chamber is rotatably mounted within the housing. The chamber includes a chamber base and a sidewall. The side wall extends from the chamber base. At least a portion of the sidewall is defined by a filter that permits passage of a first component of the multi-component composition out of the chamber through the filter and to the housing base. The filter restricts passage of a second component of the multi-component composition through the filter. The withdrawal port extends from a position proximate to the housing base to an exterior of the device. The withdrawal port permits the withdrawal of the first component from the housing base to an exterior of the device.
    Type: Grant
    Filed: March 6, 2009
    Date of Patent: May 29, 2012
    Assignee: Biomet Biologics, LLC
    Inventors: Barry F. Hecker, Michael D. Leach
  • Patent number: 8177072
    Abstract: A device for separating and isolating components of a biological fluid comprising a container for containing the fluid to be processed, a tube cap assembly for closing the container while providing filling and extraction communication therewith, a float assembly disposed within the container for funneling and controlling biological fluid flow into an inverted domed shaped isolation chamber within the float and controlling the biological fluid flow out of the isolation chamber for effecting an encapsulation or a sealed isolation of at least one component or fraction of the biological fluid flow within the isolation chamber during a centrifugation process. The device further comprising a flexible tube for connecting an extraction passageway disposed within the float assembly and an extraction valve of the tube cap assembly for allowing extraction of at least the one component or fraction encapsulated or isolated within the chamber.
    Type: Grant
    Filed: December 4, 2008
    Date of Patent: May 15, 2012
    Assignee: ThermoGenesis Corp.
    Inventors: John R. Chapman, Vijay Kumar, Brian K. Cinquini, Phillip D. Kingsley
  • Patent number: 8173027
    Abstract: Method for separating a volume of composite liquid into at least a first component and a second component including centrifuging a separation bag containing a volume of composite liquid and a volume of gas so as to sediment at least a first component and a second component separation bag; displacing a volume of hydraulic fluid against the separation bag to cause a transfer of at least one fraction of the content of the separation bag into at least one component bag connected to the separation bag; determining the volume of hydraulic fluid displaced and determining the volume of the composite liquid or the transferred components from the determined volume of displaced hydraulic fluid.
    Type: Grant
    Filed: August 28, 2007
    Date of Patent: May 8, 2012
    Assignee: Terumo BCT, Inc.
    Inventors: Niclas Högberg, Brian M. Holmes, Briden Ray Stanton, Lars Persson, Lars Strandberg, Peter Pihlstedt
  • Patent number: 8167139
    Abstract: The invention includes compositions of stem and progenitor cells recovered from bone marrow or cord blood containing most of the viable CD34+ cells and substantially depleted of red blood cells resident in the original sample, without any xenobiotic additives to aid cell separation. The invention also includes a system and method for preparing the compositions. The system includes a bag set and a processing device, which utilizes an optical sensor, microcontroller, servo motor, accelerometer, load cell, and battery. The system and method utilize centrifugation to stratify the cells into layers and then separate and transfer the stem cells into a stem cell bag. The processing device's microcontroller receives input from the device's accelerometer, load cell and optical sensor to direct the metering valve in the bag set to open and close to permit the transfer of as many stems cells as possible with as few red cells as possible.
    Type: Grant
    Filed: July 6, 2007
    Date of Patent: May 1, 2012
    Assignee: ThermoGenesis Corp.
    Inventors: Philip H. Coelho, Bruce A. Baker, John R. Chapman, Junzhi Li, Prince Emmanuel, Robert S. Childers