Methods Patents (Class 250/282)
  • Patent number: 11127579
    Abstract: A zircon ID-TIMDS Pb isotope determination method by multiple ion counters with a dynamic multi-collection protocol is provided. Compared with a commonly used multi-ion counter static determination method, the method provided by the present invention completely eliminates influences of gain differences of the different ion counters on determination results of Pb isotopes. Compared with a conventional single-ion counter determination method with five times of peak-jumps, the method provided by the present invention can obtain all of Pb isotope ratios with two times of peak-jumps, which increases the collection efficiency of Pb isotope ion beams and decreases influences of ion beam stability on Pb isotope analysis results.
    Type: Grant
    Filed: June 29, 2020
    Date of Patent: September 21, 2021
    Assignee: Institute of Geology and Geophysics, Chinese Academy of Sciences
    Inventors: Zhuyin Chu, Chaofeng Li, Wengui Liu, Wei Wang, Jinghui Guo
  • Patent number: 11125657
    Abstract: A system for sampling a surface includes a sampling probe including a housing with a probe end having a sampling fluid opening, a sampling fluid supply conduit and a sampling fluid exhaust conduit. The sampling fluid supply conduit supplies sampling fluid to the sampling fluid opening. The sampling fluid exhaust conduit includes a wall, a sampling fluid exhaust conduit inlet opening for removing sampling fluid from the sampling fluid opening, and a sampling fluid exhaust conduit outlet opening for removing fluid from the sampling fluid exhaust conduit. A sampling fluid analytic conduit is also provided in the sampling probe and has a sampling fluid analytic conduit inlet opening spaced upstream from the sampling fluid exhaust conduit outlet opening, downstream from the sampling fluid exhaust conduit inlet opening, and from the wall of the sampling fluid exhaust conduit. A wash conduit can also be provided. Methods for sampling are also disclosed.
    Type: Grant
    Filed: January 30, 2018
    Date of Patent: September 21, 2021
    Assignee: UT-BATTELLE, LLC
    Inventor: Gary Van Berkel
  • Patent number: 11127576
    Abstract: An ambient or atmospheric pressure ion source is disclosed that comprises a laser source (1) that generates ions and/or neutral particles from a target (2). A transfer device (10) causes the ions and/or neutral particles to pass along a first path or axis within the transfer device (10), while a secondary activation device (6) directs laser radiation or photons along, across or over at least a portion of the first path or axis to cause secondary activation of the ions and/or neutral particles.
    Type: Grant
    Filed: November 17, 2017
    Date of Patent: September 21, 2021
    Assignee: Micromass UK Limited
    Inventors: Jeffery Mark Brown, Steven Derek Pringle
  • Patent number: 11120979
    Abstract: A time-of-flight mass spectrometer includes a beam irradiation unit that generates an ionized particle by emitting an ion beam in a pulse form to a sample, a mass spectrometry unit that causes the ionized particle to fly, an MCP disposed in the mass spectrometry unit to measure a mass by amplifying the ionized particle, an MCP power source that applies a voltage to the MCP, and an MCP gain adjustment unit that adjusts a gain of the voltage. The MCP gain adjustment unit adjusts the gain of the voltage until a subsequent pulse is emitted after the beam irradiation unit emits a first pulse of the ion beam.
    Type: Grant
    Filed: August 20, 2020
    Date of Patent: September 14, 2021
    Assignee: KIOXIA CORPORATION
    Inventor: Jun Asakawa
  • Patent number: 11107666
    Abstract: Systems and methods are used to analyze a sample using variable mass selection window widths. A tandem mass spectrometer is instructed to perform at least two fragmentation scans of a sample with different mass selection window widths using a processor. The tandem mass spectrometer includes a mass analyzer that allows variable mass selection window widths. The selection of the different mass selection window widths can be based on one or more properties of sample compounds. The properties may include a sample compound molecular weight distribution that is calculated from a molecular weight distribution of expected compounds or is determined from a list of molecular weights for one or more known compounds. The tandem mass spectrometer can also be instructed to perform an analysis of the sample before instructing the tandem mass spectrometer to perform the at least two fragmentation scans of the sample.
    Type: Grant
    Filed: November 2, 2020
    Date of Patent: August 31, 2021
    Assignee: DH Technologies Development Pte. Ltd.
    Inventors: Ronald F. Bonner, Stephen A. Tate
  • Patent number: 11107670
    Abstract: A method for analyzing a gas by mass spectrometry includes exciting ions of the gas to be analyzed in an FT ion trap, and recording a first frequency spectrum in a first measurement time interval during or after the excitation of the ions. The first frequency spectrum contains ion frequencies of the excited ions and interference frequencies. The method also includes recording a second frequency spectrum in a second measurement time interval. The second frequency spectrum contains the interference frequencies, but not the ion frequencies of the first frequency spectrum. The method further includes comparing the first frequency spectrum with the second frequency spectrum to identify the interference frequencies in the first frequency spectrum. The disclosure also relates to a mass spectrometer which is suitable for carrying out the method for analyzing the gas by mass spectrometry.
    Type: Grant
    Filed: November 18, 2019
    Date of Patent: August 31, 2021
    Assignee: Leybold GmbH
    Inventors: Michel Aliman, Alexander Laue, Andreas Schuetz, Ruediger Reuter
  • Patent number: 11107667
    Abstract: A mass spectrometer includes an ion source configured to ionize a sample to produce ions; a mass analyzer configured to separate the ions based on their mass-to-charge ratio; a detector configured to detect ions; an ion optics component configured to direct ions along at least part of the path from the ion source to the mass analyzer to the detector; and a controller. The controller is configured to switch the source at a first time from a first polarity source voltage to a second polarity source voltage; and switch the detector or the ion optics component at a second time from a first voltage to a second voltage, the second time being offset from the first time, the first voltage being the first polarity detector voltage or the first polarity ion optics voltage and the second voltage being the second polarity detector voltage or the second polarity ion optics voltage.
    Type: Grant
    Filed: August 7, 2020
    Date of Patent: August 31, 2021
    Assignee: Thermo Fisher Scientific
    Inventors: Mikhail V. Ugarov, Oleg Silivra
  • Patent number: 11105823
    Abstract: The disclosure provides methods for differentiating between non-alcoholic fatty liver disease and non-alcoholic steatohepatitis. The method includes measuring eicosanoids and fatty acid levels in a biological sample.
    Type: Grant
    Filed: February 12, 2016
    Date of Patent: August 31, 2021
    Assignee: The Regents of the University of California
    Inventors: Edward A. Dennis, Oswald Quehenberger, Rohit Loomba
  • Patent number: 11101120
    Abstract: The disclosure includes an ionization chamber, a first electron multiplier, and a second electron multiplier. The ionization chamber is configured to receive gas molecules from an environment at a pressure. The first electron multiplier is configured to receive a plurality of photons from a photon source, generate a first plurality of electrons from the plurality of photons, and discharge the first plurality of electrons into the ionization chamber to generate a plurality of gas ions from at least a portion of the gas molecules. The second electron multiplier is configured to receive the plurality of gas ions from the ionization chamber and generate a second plurality of electrons from the plurality of gas ions that is proportional to a quantity of the plurality of gas ions. A quantity of electrons of the second plurality of electrons is indicative of the pressure.
    Type: Grant
    Filed: October 25, 2019
    Date of Patent: August 24, 2021
    Assignee: SRI International
    Inventors: Ashish Chaudhary, Robert Timothy Short
  • Patent number: 11099169
    Abstract: Two-pore devices and method for sequencing are described. A two-pore device can include first chamber, a second chamber, and a third chamber, wherein the first chamber is in communication with the second chamber through a first nanopore, and wherein the second chamber is in communication with the third chamber through a second nanopore. The device can also include sensing circuitry for measuring electrical signals associated with a target at a nanopore, and control circuitry for controlling motion of the target at a nanopore. The device can include and/or switch between sensing and control modes for each of the first nanopore and the second nanopore. Sequencing methods can implement a two-pore device in relation to translocation of a target through one or more nanopores, switching between sensing and control modes as appropriate, and measuring aspects of the target using in sensing modes.
    Type: Grant
    Filed: June 14, 2018
    Date of Patent: August 24, 2021
    Assignee: Nooma Bio, Inc.
    Inventors: Reto Stamm, Michael Summers, Eric Thorne, William B. Dunbar
  • Patent number: 11101127
    Abstract: An acceleration voltage generator (7) generates a high-voltage pulse to be applied to an electrode in an orthogonal accelerator by turning on/off a high DC voltage generated by a high-voltage power source through MOSFETs (741) in a switch circuit (74). A controller (6) sends driving pulse signals to the switch circuit (74) through a primary-side driver section (71), transformer (72) and secondary driver section (73). An adjustment circuit (742) formed by a gate resistor (742a) and gate capacitor (742b) is provided between the secondary-side driver section (73) and the MOSFET (741). The resistance value of the resistor (742a) and the capacitance value of the capacitor (742b) are determined so as to suppress an overshoot of the gate voltage due to the resonance while preventing a decrease in steepness of the waveform in its rising and falling phases.
    Type: Grant
    Filed: November 2, 2017
    Date of Patent: August 24, 2021
    Assignee: SHIMADZU CORPORATION
    Inventor: Shiro Mizutani
  • Patent number: 11099153
    Abstract: An ion mobility device includes a plurality of electrodes and a current source. The plurality of electrodes arranged along an axis extending from a first end to a second end. The plurality of electrodes configured to receive a gas flow at the second end and provide for an expansion of the gas flow from the second end to the first end such that a first gas velocity at the second end is greater than a second gas velocity at the first end. The current source is configured to apply a first potential to the plurality of electrodes to generate a first electric field during a trapping and equilibration time period; and apply a second potential to the electrodes during an ejection time period to generate a second electric field, the second electric field being greater than the first electric field.
    Type: Grant
    Filed: April 3, 2020
    Date of Patent: August 24, 2021
    Assignee: Thermo Finnigan LLC
    Inventor: Viatcheslav V. Kovtoun
  • Patent number: 11094516
    Abstract: A device that performs MSn analysis including: a mass window group setting information input receiver that receives input of information concerning the number of mass window groups, the number of mass windows, and a mass-to-charge ratio width of each of the mass windows; a mass window group setter that sets a first mass window group and a second mass window group, in which a mass-to-charge ratio at a boundary of adjacent mass windows differs from a mass-to-charge ratio at a boundary of mass windows in the first mass window group; a product-ion scan measurement section that performs, for each of the first and second mass window groups, an operation of performing scan measurement of product ions by use of the plurality of mass windows in sequence to acquire pieces of product-ion scan data; and a product-ion spectrum generator that generate a product-ion spectrum by integrating pieces of product-ion scan data.
    Type: Grant
    Filed: July 10, 2017
    Date of Patent: August 17, 2021
    Assignee: SHIMADZU CORPORATION
    Inventors: Hideki Yamamoto, Atsuhiko Toyama
  • Patent number: 11094521
    Abstract: Disclosed herein is an ion analysis instrument comprising a Time of Flight (“TOF”) mass analyser comprising a reflectron. The instrument is operable in at least a first mode and a second mode, wherein in said first mode ions are caused to turn around at a first point in the reflectron and wherein in said second mode ions are caused to turn around at a second point in the reflectron such that the distance traveled by ions within the Time of Flight mass analyser is greater in the second mode than the distance traveled by ions within the Time of Flight mass analyser in the first mode. In this way, the operating modes can be selectively optimised for the analysis of ions of different masses.
    Type: Grant
    Filed: October 18, 2017
    Date of Patent: August 17, 2021
    Assignee: MICROMASS UK LIMITED
    Inventor: Jeffery Mark Brown
  • Patent number: 11092591
    Abstract: Provided are methods of determining prior radiation dose exposure levels for subjects, and kits therefor. Also provided are methods of treatment.
    Type: Grant
    Filed: November 13, 2015
    Date of Patent: August 17, 2021
    Assignee: Albert Einstein College of Medicine
    Inventors: Aaron Alain-Jon Golden, Pilib Ó Broin, Chandan Guha, Irwin Kurland
  • Patent number: 11094519
    Abstract: An apparatus for performing ambient ionisation mass and/or ion mobility spectrometry is disclosed. The apparatus comprises a substantially cylindrical, tubular, rod-shaped, coil-shaped, helical or spiral-shaped collision assembly; and a first device arranged and adapted to direct analyte, smoke, fumes, liquid, gas, surgical smoke, aerosol or vapour onto said collision assembly.
    Type: Grant
    Filed: April 29, 2020
    Date of Patent: August 17, 2021
    Assignee: Micromass UK Limited
    Inventors: Tamas Karancsi, Daniel Simon, Lajos Godorhazy, Daniel Szalay, Steven Derek Pringle, Emrys Jones, Ian Trivett, Stephen O'Brien, Anthony Hesse, Matt Henderson, Alvin Chua, Zoltan Takáts
  • Patent number: 11094517
    Abstract: A method for preparing a measurement sample for MALDI mass spectrometry, the method including applying a laser beam to a base containing a matrix disposed on a surface of the base, in a manner that the laser beam is applied to a surface of the base opposite to the surface on which the matrix is disposed, to make the matrix fly from the base to be disposed at a predetermined position of an analyte of MALDI mass spectrometry.
    Type: Grant
    Filed: February 26, 2020
    Date of Patent: August 17, 2021
    Assignee: RICOH COMPANY, LTD.
    Inventors: Katsuyuki Uematsu, Kazumi Suzuki
  • Patent number: 11094522
    Abstract: To compensate for the distortion of the loop-flight electric field with a higher level of accuracy, a multiturn time-of-flight mass spectrometer 1 includes: a main electrode 21 configured to generate, within a predetermined loop-flight space, a loop-flight electric field which is an electric field that makes an ion fly in a loop orbit multiple times, the main electrode having an opening 24 or 25 through which ions are introduced into or extracted from the loop-flight space; a compensating-electrode attachment part 23 made of an insulating material and fixed to the main electrode; and a compensating electrode 22 configured to compensate for a distortion of the loop-flight electric field which occurs in the vicinity of the opening, the compensating electrode being fixed to the compensating-electrode attachment part directly or via a substrate 221 and located in the vicinity of the opening.
    Type: Grant
    Filed: October 1, 2020
    Date of Patent: August 17, 2021
    Assignee: SHIMADZU CORPORATION
    Inventors: Hiroyuki Miura, Hideaki Izumi
  • Patent number: 11092569
    Abstract: A system for detecting a chemical substance of interest among a plurality of different chemical substances comprises an inlet, an ionization module, a high-field asymmetric waveform ion mobility spectrometry (FAIMS) cell, and optionally a detector. A focussing module and/or a flow control gas supply can be provided. The system has example applications for molecules including ?-9-tetrahydrocannabinol (THC), its metabolites and/or other substances of interest from a breath of a subject or from a breath sample obtained from a subject.
    Type: Grant
    Filed: September 14, 2020
    Date of Patent: August 17, 2021
    Assignee: CANNABIX TECHNOLOGIES INC.
    Inventors: Rajpaul Attariwala, Daryoush Sahebjavaher, Jared Boock, Mikko Maatta
  • Patent number: 11087968
    Abstract: A traveling wave multipole comprising two or more pairs of segmented electrodes arranged around a central axis; and a voltage supply. The voltage supply configured to supply the segments of each pair of electrodes with a different RF and DC potential; and match RF and DC potentials with a location of an ion of target m/z moving through the traveling wave multipole such that as the ion travels along the multipole the ion experiences the same RF and DC potentials while another ion of a second target m/z concurrently experiences a different RF and DC potentials at another location within the traveling wave multipole.
    Type: Grant
    Filed: December 5, 2019
    Date of Patent: August 10, 2021
    Assignee: THERMO FINNIGAN LLC.
    Inventors: David A. Schell, Joshua T. Maze
  • Patent number: 11085936
    Abstract: A method and kit the simultaneous analysis of thyroid hormones (THs) and related metabolites in serum are disclosed. The method includes the extraction of THs and related metabolites, the derivatization of THs and related metabolites with 5-N-succinimidoxy-5-oxopentyl)triphenylphosphonium bromide (SPTPP), and the analysis of SPTPP derivatives using ultra-high-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). Free or total THs (T3 and T4) together with their related metabolites (MIT, DIT, T0, T1, rT1, 3,3?-T2, 3,5-T2, and rT3) can be determined simultaneously, rapidly, and accurately. This invention overcomes the limitation that the traditional method can only be used for the analysis of T3 and T4 with low specificity. The invention exhibits extremely high analytical sensitivity for all of the target analytes (femtogram level).
    Type: Grant
    Filed: April 9, 2019
    Date of Patent: August 10, 2021
    Assignee: Peking University
    Inventors: Yi Wan, Hongyang Cui, Hang Liu, Shixiong Gao
  • Patent number: 11075069
    Abstract: An octa-electrode linear ion trap mass analyzer is formed by eight cylindrical electrodes and at least two end-cap electrodes. The inside surfaces of the eight cylindrical electrodes are free-form. The material of the octa-electrode linear ion trap mass analyzer is a conductive metal material or an insulating material plated with a conductive coating. The eight cylindrical electrodes are divided into four groups of cylindrical electrodes in total, each group of the four groups of cylindrical electrodes comprises two cylindrical electrodes, and each two groups of the four groups of cylindrical electrodes are parallelly placed. At least one through hole is provided with in the center of the end-cap electrode, and the two end-cap electrodes are respectively arranged at both ends of the cylindrical electrode.
    Type: Grant
    Filed: August 3, 2018
    Date of Patent: July 27, 2021
    Assignee: SHANGHAI YUDA INDUSTRIAL CO., LTD.
    Inventors: Yu Xiao, Rujiao Yao, Xiaojun Qi, Jian Jiang, Yongyong Zhu
  • Patent number: 11069516
    Abstract: One or more ions are received along a central axis through a first set of reflectron plates of an ELIT. Voltages are applied to the first set of plates and to a second set of reflectron plates in order to trap and oscillate the one or more ions. A first induced current is measured from a cylindrical pickup electrode between the first set of reflectron plates and the second set of reflectron plates. A second induced current is measured from one or more plates of the first set of reflectron plates. A third induced current is measured from one or more plates of the second set of reflectron plates. The first measured induced current, second measured induced current and third measured induced current are combined to reduce higher order frequency harmonics of the induced current.
    Type: Grant
    Filed: September 13, 2018
    Date of Patent: July 20, 2021
    Assignee: DH Technologies Development Pte. Ltd.
    Inventors: Takashi Baba, Eric Thomas Dziekonski
  • Patent number: 11069517
    Abstract: A system is disclosed for identifying precursor ions originating from an ion source device. A mass filter filters an ion beam by using a series of overlapping precursor ion mass selection windows across the precursor ion mass range. A mass analyzer analyzes the precursor ions of each precursor ion mass selection window of the series, producing a plurality of precursor ion spectra for the precursor ion mass range. A precursor ion is selected from the spectra. The intensities for the selected precursor ion are retrieved from the spectra and a trace is produced that describes how the intensity of the selected precursor ion varies with the location of the precursor ion mass selection window. The selected precursor ion is identified as a precursor ion originating from the ion source device if the trace includes a nonzero intensity for the m/z value of the selected precursor ion.
    Type: Grant
    Filed: February 1, 2018
    Date of Patent: July 20, 2021
    Assignee: DH Technologies Development Pte. Ltd.
    Inventor: Stephen Alexander Tate
  • Patent number: 11057410
    Abstract: Methods and systems for detecting a data exfiltration event on a network. The method includes receiving traffic data and applying a transformation to transform the traffic data at least closer to a normal distribution. The method further includes selecting at least one outlier identification technique based on a property of the transformed data, and then executing the at least one selected identification technique to determine whether the traffic data is indicative of a data exfiltration event.
    Type: Grant
    Filed: February 27, 2019
    Date of Patent: July 6, 2021
    Assignee: Rapid7, Inc.
    Inventors: Dustin Myers, Vasudha Shivamoggi, Roy Hodgman
  • Patent number: 11053120
    Abstract: A method for the production of nitric acid, comprising a step of oxidation of ammonia in the presence of a catalyst, comprising a step of monitoring the temperature of said catalyst by at least one contactless infrared sensor.
    Type: Grant
    Filed: September 7, 2016
    Date of Patent: July 6, 2021
    Assignee: Casale SA
    Inventor: Jean François Granger
  • Patent number: 11049708
    Abstract: An apparatus for performing ambient ionisation mass and/or ion mobility spectrometry is disclosed. The apparatus comprises a substantially cylindrical, tubular, rod-shaped, coil-shaped, helical or spiral-shaped collision assembly; and a first device arranged and adapted to direct analyte, smoke, fumes, liquid, gas, surgical smoke, aerosol or vapour onto said collision assembly.
    Type: Grant
    Filed: April 29, 2020
    Date of Patent: June 29, 2021
    Assignee: Micromass UK Limited
    Inventors: Tamas Karancsi, Daniel Simon, Lajos Godorhazy, Daniel Szalay, Steven Derek Pringle, Emrys Jones, Ian Trivett, Stephen O'Brien, Anthony Hesse, Matt Henderson, Alvin Chua, Zoltan Takáts
  • Patent number: 11047828
    Abstract: The invention provides a method for acquiring as many fragment mass spectra of selected substances, e.g. proteins, of complex mixtures, as possible using a hybrid mass spectrometric system which comprises an ion source, an ion mobility separator, a mass filter, a fragmentation cell, and a mass analyzer. The fragment mass spectra are used for identifying the substances by their fragment mass spectra. The invention proposes to control the dwell time of the mass filter and to adapt the dwell time to the length of the ion mobility signal in a mass-mobility map.
    Type: Grant
    Filed: April 2, 2020
    Date of Patent: June 29, 2021
    Inventors: Oliver Räther, Markus Lubeck
  • Patent number: 11049703
    Abstract: The present invention comprises novel methods of continuously monitoring the performance of an atmospheric pressure ionization (API) system. The methods of the invention allow for improved quality monitoring of the processes that leads to the formation of ions at atmospheric pressure. The methods of the invention further allow for continuously monitoring for the quality of the ion formation process in API without the addition of extraneous material (such as labelled compounds or control known compounds) to the system being monitored.
    Type: Grant
    Filed: August 19, 2016
    Date of Patent: June 29, 2021
    Assignee: PharmaCadence Analytical Services, LLC
    Inventors: Richard C. King, III, William J. Metzler, IV
  • Patent number: 11043366
    Abstract: A method of analyzing molecules, comprising: generating ions from a sample of molecules; cooling the generated ions below ambient temperature; fragmenting at least some of the cooled ions by irradiating the ions with light at a plurality of different wavelengths (?) within one or more predetermined spectral intervals; recording a fragment mass spectrum of the fragmented ions comprising a detected signal (I) versus m/z over a predetermined range of m/z values for each of the plurality of different wavelengths (?), thereby recording a two-dimensional dependency of the detected signal (I) on m/z and irradiation wavelength (?); and determining from the recorded two-dimensional dependency an identity of at least one of the generated ions and/or relative abundances of different generated ions and thereby determining an identity of at least of one of the molecules and/or relative abundances of different molecules in the sample.
    Type: Grant
    Filed: January 15, 2020
    Date of Patent: June 22, 2021
    Assignees: Thermo Fisher Scientific (Bremen) GmbH, ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)
    Inventors: Alexander Makarov, Oleg Boyarkine, Vladimir Kopysov
  • Patent number: 11041865
    Abstract: The present invention relates to the field of myocardial injury. More specifically, the present invention provides methods and compositions useful in the diagnosis, prognosis and/or assessment of myocardial injury. In a specific embodiment, a method comprises the steps of (a) diagnosing a subject as having myocardial injury based on the statistically significant over expression of one or more markers described herein compared to a baseline value, wherein the markers are measured in a biological sample obtained from the subject; and (b) treating the subject with one or more of an anti-thrombolysis agent, coronary bypass surgery or angioplasty.
    Type: Grant
    Filed: February 22, 2016
    Date of Patent: June 22, 2021
    Assignees: THE JOHNS HOPKINS UNIVERSITY, CEDARS-SINAI MEDICAL CENTER
    Inventors: Qin Fu, Jennifer Eileen Van Eyk, Vidya Venkatraman
  • Patent number: 11037777
    Abstract: The invention generally relates to systems and methods for separating ions at about or above atmospheric pressure. In certain embodiments, the invention provides systems that include an ionization source that generates ions and an ion trap. The ion trap is maintained at about or above atmospheric pressure and includes a plurality of electrodes and at least one inlet configured to receive a gas flow and at least one outlet. The system is configured such that a combination of a gas flow and one or more electric fields produced by the electrodes separates the ions based on mass-to-charge ratio and sends the separated ions through the at least one outlet of the ion trap.
    Type: Grant
    Filed: June 22, 2020
    Date of Patent: June 15, 2021
    Assignee: Purdue Research Foundation
    Inventors: Robert Graham Cooks, Dalton Snyder, Amar S. Basu, Wen-Ping Peng
  • Patent number: 11031222
    Abstract: A method is disclosed comprising obtaining or acquiring chemical or other non-mass spectrometric data from one or more regions of a target using a chemical sensor. The chemical or other non-mass spectrometric data may be used to determine one or more regions of interest of the target. An ambient ionisation ion source may then be used to generate aerosol, smoke or vapour from one or more regions of the target.
    Type: Grant
    Filed: March 7, 2016
    Date of Patent: June 8, 2021
    Assignee: Micromass UK Limited
    Inventors: Steven Derek Pringle, Emrys Jones, Michael Raymond Morris, Julia Balog, James Ian Langridge, Keith Richardson, Daniel Simon, Lajos Godorhazy, Daniel Szalay, Zoltan Takats
  • Patent number: 11031220
    Abstract: An ion detection system is disclosed that comprises one or more first devices (11) configured to produce secondary electrons in response to incident ions. The one or more first devices (11) comprise a first ion collection region and a second ion collection region and are configured to produce first secondary electrons in response to one or more ions incident at the first ion collection region and to produce second secondary electrons in response to one or more ions incident at the second ion collection region. The ion detection system also comprises a first output device (14) configured to output a first signal in response to first secondary electrons produced by the one or more first devices (11) and a second output device (15) configured to output a second signal in response to second secondary electrons produced by the one or more first devices (11).
    Type: Grant
    Filed: October 25, 2017
    Date of Patent: June 8, 2021
    Assignee: Micromass UK Limited
    Inventors: Martin Raymond Green, Jason Lee Wildgoose
  • Patent number: 11031228
    Abstract: A mass spectrometry device according to one aspect of the invention includes: a sample stage on which a sample is placed and on which a sample support having a substrate, in which a plurality of through-holes passing from one surface thereof to the other surface thereof are provided, and a conductive layer, which covers at least a portion of the one surface which is not provided with the through-holes, is placed such that the other surface faces the sample; a laser beam application unit that controls application of a laser beam such that the laser beam is applied to an imaging target region on the one surface; and a detector that detects the sample ionized by the application of the laser beam in a state where a positional relation of the sample in the imaging target region is maintained.
    Type: Grant
    Filed: March 1, 2018
    Date of Patent: June 8, 2021
    Assignee: HAMAMATSU PHOTONICS K.K.
    Inventors: Yasuhide Naito, Masahiro Kotani, Takayuki Ohmura
  • Patent number: 11025028
    Abstract: Provided is a carbon isotope analysis device including a carbon dioxide isotope generator provided with a combustion unit that generates gas containing carbon dioxide isotope from carbon isotope, and a carbon dioxide isotope purifying unit; a spectrometer including optical resonators having a pair of mirrors, and a photodetector that determines intensity of light transmitted from the optical resonators; and a light generator including a single light source, a first optical fiber that transmits first light from the light source, a second optical fiber that generates second light of a longer wavelength than the first light, the second optical fiber splitting from the first optical fiber and coupling therewith downstream, a first amplifier on the first optical fiber, a second amplifier on the second optical fiber, different in band from the first amplifier, and a nonlinear optical crystal.
    Type: Grant
    Filed: August 24, 2018
    Date of Patent: June 1, 2021
    Assignees: NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY, SEKISUI MEDICAL CO., LTD.
    Inventors: Tetsuo Iguchi, Hideki Tomita, Norihiko Nishizawa, Volker Sonnenschein, Ryohei Terabayashi, Atsushi Satou
  • Patent number: 11022581
    Abstract: Embodiments of the present disclosure provide an ion mobility spectrometer device. The ion mobility spectrometer device includes: an ion mobility tube, a sampling device, and a sampling and circulating gas path. The sampling device includes a solid sample desorption device and a gas sampling device. The solid sample desorption device is configured to process the solid sample into a first mixed gas containing the solid sample, and the gas sampling device is configured to process the gas sample into a second mixed gas containing the gas sample. The sampling and circulating gas path is configured to transfer the first mixed gas and/or the second mixed gas into the ion mobility tube for detection.
    Type: Grant
    Filed: December 26, 2019
    Date of Patent: June 1, 2021
    Assignees: NUCTECH COMPANY LIMITED, Tsinghua University
    Inventors: Qingjun Zhang, Yuanjing Li, Zhiqiang Chen, Jianmin Li, Yaohong Liu, Weiping Zhu, Qiufeng Ma, Biao Cao, Ge Li, Wei Wang, Lili Yan, Guangqin Li
  • Patent number: 11017990
    Abstract: A miniature mass spectrometer includes an atmospheric pressure ionisation source and a first vacuum chamber having an atmospheric pressure sampling orifice or capillary, a second vacuum chamber downstream of the first vacuum chamber, and a third vacuum chamber downstream of the second vacuum chamber. An ion detector is located in the third vacuum chamber. A first RF ion guide is located within the first vacuum chamber and a second RF ion guide is located within the second vacuum chamber. The ion path length from the atmospheric pressure sampling orifice or capillary to an ion detecting surface of the ion detector is ?400 mm. The mass spectrometer also includes a tandem quadrupole mass analyser, 3D ion trap mass analyser, 2D or linear ion trap mass analyser, Time of Flight mass analyser, quadrupole-Time of Flight mass analyser, or electrostatic mass analyser arranged in the third vacuum chamber.
    Type: Grant
    Filed: July 15, 2020
    Date of Patent: May 25, 2021
    Assignee: Micromass UK Limited
    Inventors: David Gordon, Daniel James Kenny
  • Patent number: 11011362
    Abstract: A mass spectrometer includes an ion source, an ion guide, a first gate, first and second mass filters, a fragmentation cell, a detector, and a controller. The ion source is configured to produce an ion beam from a sample. The first and second mass filters are configured to selectively transmit ions within a mass-to-charge range and reject ions outside of the mass-to-charge range. The detector is configured to measure the intensity of the transmitted ion beam. The controller is configured to close the first ion gate to prevent ions from entering the first mass filter, switch a first quadrupole voltage of the first mass filter to a voltage of a first transition, and open the first ion gate to allow ions to enter the first mass filter, the opening offset from the switching by at least the time required to adjust the voltage of the first mass filter.
    Type: Grant
    Filed: September 19, 2019
    Date of Patent: May 18, 2021
    Assignee: Thermo Finnigan LLC
    Inventor: Mikhail V. Ugarov
  • Patent number: 11004672
    Abstract: A mass selective ion trapping device includes a linear ion trap and a RF control circuitry. The ion trap includes a plurality of trap electrodes configured for generating a quadrupolar trapping field in a trap interior and for mass selective ejection of ions from the trap interior. The RF control circuitry is configured to apply a balanced AC voltage to the trap electrodes during a first period of time such that an AC voltage applied to a first pair of trap electrodes is of the same magnitude and of opposite sign to an AC voltage applied to a second pair of trap electrodes; apply unbalanced RF voltage to the second pair of trap electrodes during a second period of time; ramp the balanced AC voltage down and the unbalanced RF voltage up during a transition period; and eject ions from the linear ion trap after the second period of time.
    Type: Grant
    Filed: August 27, 2019
    Date of Patent: May 11, 2021
    Assignee: THERMO FINNIGAN LLC
    Inventor: Viatcheslav V. Kovtoun
  • Patent number: 11004668
    Abstract: A mass spectrometer is disclosed comprising a first device, a second device and a switch arranged and adapted: (i) to direct ions at a first time T1 to the first device and to substantially prevent ions from entering the second device; and (ii) to direct ions at a second later time T2 to the second device and to substantially prevent ions from entering the first device. At the first time T1 the second device may not be in an operational state to potentially optimally fragment, react, mass filter or otherwise process ions since the second device may be in a process of equilibration, changing state, re-filling, recharging, transition, replenishing, switching voltage or altering an operational parameter.
    Type: Grant
    Filed: June 5, 2015
    Date of Patent: May 11, 2021
    Assignee: Micromass UK Limited
    Inventors: Martin Raymond Green, David J. Langridge, Keith Richardson, Jason Lee Wildgoose
  • Patent number: 11004652
    Abstract: An object of the present invention is to provide a technique for reducing a phenomenon in which fine particles derived from a sample and bounced off by ion beam irradiation are reattached to an ion milling surface. An ion milling device of the invention includes an ion source which emits an ion beam, a chamber, a sample table in which a sample is placed in the chamber, and a shielding plate placed on the sample, and by having a magnet disposed in the chamber, reattachment of fine particles derived from the sample can be reduced.
    Type: Grant
    Filed: September 15, 2017
    Date of Patent: May 11, 2021
    Assignee: Hitachi High-Tech Corporation
    Inventors: Asako Kaneko, Hisayuki Takasu
  • Patent number: 10998178
    Abstract: The invention generally relates to systems and methods for sample analysis using swabs. In certain aspects, the invention provides systems that include a probe having a conductive proximal portion coupled to a porous material at a distal portion of the probe that is configured to retain a portion of a sample that has contacted the porous material, and a mass spectrometer having an inlet. The system is configured such that the porous material at a distal portion of the probe is aligned over the inlet of the mass spectrometer.
    Type: Grant
    Filed: August 13, 2018
    Date of Patent: May 4, 2021
    Assignee: Purdue Research Foundation
    Inventors: Robert Graham Cooks, Alan Keith Jarmusch, Valentina Pirro
  • Patent number: 10998175
    Abstract: Disclosed herein is a device for characterizing a biological sample or an airborne sample. According to embodiments of the present disclosure, the device comprises an electrospray source, a mass analyzer, a charge detector, and optionally, an ion guide. The present device is useful in analyzing the particle population in the biological or airborne sample based on the mass to charge (m/z) ratio and the charge (z) of each particle. Also disclosed herein are the methods of making a diagnosis of cancer by use of the present device, and methods of determining the mass distribution of particles in an airborne sample.
    Type: Grant
    Filed: November 17, 2019
    Date of Patent: May 4, 2021
    Assignee: ACADEMIA SINICA
    Inventors: Abdil Ozdemir, Jung-Lee Lin, Chung-Hsuan Chen
  • Patent number: 10998177
    Abstract: An ion analyzer that generates product ions from precursor ions derived from a sample component and analyzes the product ions includes a reaction chamber (2) into which the precursor ion is introduced, a radical generation chamber (51), a material gas supply source (52) configured to introduce material gas into the radical generation chamber (51), a vacuum evacuator (57) configured to evacuate the radical generation chamber (51), a vacuum discharge unit (53) configured to generate a vacuum discharge in the radical generation chamber (51), a radical irradiation unit (54) configured to irradiate an inside of the reaction chamber (2) with radicals generated from the material gas in the radical generation chamber (51), and a separation and detection (3) configured to separate and detect product ions generated from the precursor ion by reaction with the radicals according to at least one of a mass-to-charge ratio and ion mobility.
    Type: Grant
    Filed: March 29, 2018
    Date of Patent: May 4, 2021
    Assignees: SHIMADZU CORPORATION, THE DOSHISHA
    Inventors: Hidenori Takahashi, Motoi Wada
  • Patent number: 10989698
    Abstract: A data independent acquisition method of mass spectrometry for analysing a sample as it elutes from a chromatography system is disclosed. The method comprises selecting a precursor mass range, and performing a plurality of MS1 scans and sets of MS2 scans across the precursor mass range. Each of the MS1 scans uses a mass analyser operated at a first, relatively higher resolution, for identification and/or quantitation of the sample in the MS1 domain. The set of MS2 scans comprises performing MS2 scans of fragmented mass range segments performed with the mass analyser, operated at a second, relatively lower resolution. In the method, the MS1 scans are interleaved throughout the performing of the set of MS2 scans such that the MS1 scans provide a mass chromatogram of the sample. The ratio of the number of MS1 scans to sets of MS2 scans performed across the chromatographic peak width is at least 3:1.
    Type: Grant
    Filed: May 5, 2020
    Date of Patent: April 27, 2021
    Assignee: Thermo Fisher Scientific (Bremen) GmbH
    Inventor: Yue Xuan
  • Patent number: 10991568
    Abstract: An ion resonance excitation operation method and device by applying a quadrupolar electric field combined with a dipolar electric field. The method includes applying a main RF to any pair of plates of the ion trap mass analyzer, and applying a quadrupolar excitation signal to any pair of plates, and applying a reverse phase dipolar excitation signal to any pair of plates. Also provided is an ion resonance excitation operation method and device by using a quadrupolar electric field combined with a dipolar electric field, which includes applying a positive main RF to a pair of electrode rods of the quadrupole, and applying a negative main RF to the other pair of electrode rods; applying a quadrupolar excitation signal to any pair of electrode rods, applying a reverse phase dipolar excitation signal to any pair of electrode rods.
    Type: Grant
    Filed: August 5, 2019
    Date of Patent: April 27, 2021
    Assignee: BEIJING INSTITUTE OF TECHNOLOGY
    Inventors: Wei Xu, Ting Jiang, Qi Guo, Qian Xu
  • Patent number: 10985001
    Abstract: A rapid online analyzer for a 14C-AMS, comprising: a solid sample processing module, an atmospheric sample collection and processing module, a microflow control module, an AMS module and an automatic control module. Sample preparation and AMS measurement are combined, a solid sample is directly converted into CO2 gas by an element analyzer and then enters an AMS for measurement, and an atmospheric sample is collected in real time for analysis by the AMS, such that quick and efficient analysis of the solid sample and the atmospheric sample is realized.
    Type: Grant
    Filed: January 7, 2019
    Date of Patent: April 20, 2021
    Assignee: INSTITUTE OF EARTH ENVIRONMENT, CHINESE ACADEMY OF SCIENCES
    Inventors: Yun-Chong Fu, Hua Du, Peng Cheng, Shugang Wu, Wei-Jian Zhou
  • Patent number: 10983098
    Abstract: A liquid chromatograph includes a column 13, a liquid sending unit 11 configured to send a mobile phase to the column 13 at a pressure higher than atmospheric pressure, a first pipe 201a having one end connected to an outlet of the column 13, and a second pipe 201b having one end connected to an end face at the other end of the first pipe 201a with a connection gap sandwiched between the one end of the second pipe and end face, the second pipe 201b having the other end disposed in an ionization chamber 20 having a pressure less than or equal to atmospheric pressure. The liquid chromatograph charges a component of a sample contained in a liquid flowing out from the column 13 by applying voltage to the connection gap, and inner diameters and lengths of the first pipe 201a and the second pipe 201b are determined such that the liquid flowing out from the column 13 passes through the connection gap while maintaining pressure greater than or equal to a saturated vapor pressure of the mobile phase.
    Type: Grant
    Filed: September 14, 2017
    Date of Patent: April 20, 2021
    Assignee: SHIMADZU CORPORATION
    Inventor: Wataru Fukui
  • Patent number: 10985000
    Abstract: A system for analyzing an analyte is described herein. The system includes a chamber having an inlet and a semi-permeable membrane arranged to seal the inlet. The semi-permeable membrane includes a cross-linked mixture of a first compound and a second compound. The system can also include a radiation source arranged in the vacuum chamber, the radiation source spaced apart from the semi-permeable membrane and adapted to irradiate the semi-permeable membrane with electromagnetic radiation at a frequency at least partially absorbed by the semi-permeable membrane.
    Type: Grant
    Filed: January 29, 2018
    Date of Patent: April 20, 2021
    Assignee: INFICON, Inc.
    Inventors: Kenneth Charles Wright, Guido F. Verbeck, IV