Methods Patents (Class 250/282)
  • Patent number: 11443935
    Abstract: An acceleration voltage generator is configured to cause a power MOSFET to turn on or off to switch a high direct-current voltage, so as to generate a high-voltage pulse for an ejection of ions from an ion ejector. A drive signal is used to cause the power MOSFET to turn on, and further includes a secondary drive signal to recharge a gate capacitance to cause the power MOSFET to stay in an on-state. In a drive signal generator, edge detection circuits generate an edge detection signal based on a start signal; selection circuits generate a primary drive signal by adjusting the edge detection signal in its signal width; and a secondary drive signal generator includes multiple circuit elements such as a semiconductor element, and generates the secondary drive signal.
    Type: Grant
    Filed: May 31, 2018
    Date of Patent: September 13, 2022
    Assignee: SHIMADZU CORPORATION
    Inventor: Shiro Mizutani
  • Patent number: 11437215
    Abstract: Provided herein are approaches for decreasing particle generation in an electrostatic lens. In some embodiments, an ion implantation system may include an electrostatic lens including an entrance for receiving an ion beam and an exit for delivering the ion beam towards a target, the electrostatic lens including a first terminal electrode, a first suppression electrode, and a first ground electrode disposed along a first side of an ion beamline, wherein the first ground electrode is grounded and positioned adjacent the exit. The electrostatic lens may further include a second terminal electrode, a second suppression electrode, and a second ground electrode disposed along a second side of the ion beamline, wherein the second ground electrode is grounded and positioned adjacent the exit. The implantation system may further include a power supply operable to supply a voltage and a current to the electrostatic lens for controlling the ion beam.
    Type: Grant
    Filed: December 13, 2019
    Date of Patent: September 6, 2022
    Assignee: APPLIED Materials, Inc.
    Inventors: Alexandre Likhanskii, Antonella Cucchetti, Eric D. Hermanson, Frank Sinclair, Jay T. Scheuer, Robert C. Lindberg
  • Patent number: 11430649
    Abstract: An analytical device includes: a first acceleration unit including a first acceleration electrode to which a pulse voltage for accelerating ions is applied; a flight tube; a second acceleration unit that is arranged between the first acceleration unit and the flight tube, and includes a second acceleration electrode to which a voltage for accelerating the ions is applied; an ion detector that detects the ions; and a capacitance adjustment unit that causes adjustment of a capacitance between at least one set of electrodes among a plurality of electrodes arranged in the first acceleration unit, the second acceleration unit, and a flight tube.
    Type: Grant
    Filed: May 28, 2018
    Date of Patent: August 30, 2022
    Assignee: SHIMADZU CORPORATION
    Inventors: Shiro Mizutani, Tomoyuki Oshiro, Yuta Miyazaki
  • Patent number: 11424114
    Abstract: A plurality of known compounds with known CCS values is analyzed using a DMS device. The DMS device determines how the intensities of their transmitted ions vary with different separation voltages (SVs) and compensation voltages (CVs). A machine learning algorithm builds a data model from the known m/z value, known CCS value, and measured pairs of CV and SV values that provide optimal transmission through the DMS device for each of the known compounds. An unknown compound with an unknown CCS value is then analyzed. The DMS device determines how the intensity of its ions varies with the same different SVs and CVs. Finally, the machine learning algorithm predicts the CCS value of the unknown compound from the data model, the known m/z of the unknown compound, and the measured pairs of CV and SV values that provide optimal transmission through the DMS device for the unknown compound.
    Type: Grant
    Filed: November 19, 2018
    Date of Patent: August 23, 2022
    Assignee: DH Technologies Development Pte. Ltd.
    Inventors: John Lawrence Campbell, Scott Hopkins
  • Patent number: 11415495
    Abstract: A thermal desorber assembly includes a housing and a desorption heater element mounted in the housing with a sample cavity defined between the desorption heater element and an inner wall of the housing. An outlet port is defined in the housing. A flow channel connects the sample cavity in fluid communication with the outlet port for conveying analytes from the sample cavity to the outlet port for introducing the analytes to a spectrometer.
    Type: Grant
    Filed: July 16, 2019
    Date of Patent: August 16, 2022
    Assignee: Hamilton Sundstrand Corporation
    Inventor: Richard K. Chun
  • Patent number: 11410840
    Abstract: Calibration of a mass spectrometer is described. In one aspect, a mass spectrometer can generate an offset value indicative of the mass difference between the corrected and reference external calibrant ion data. By comparing the offset value to a threshold, a preliminary mass calibration can be modified, or a recalibration of the mass spectrometer is performed.
    Type: Grant
    Filed: January 22, 2020
    Date of Patent: August 9, 2022
    Assignee: THERMO FISHER SCIENTIFC (BREMEN) GMBH
    Inventor: Anastassios Giannakopulos
  • Patent number: 11402386
    Abstract: An integrated sample processing system including an analyzer and a mass spectrometer is disclosed. The integrated sample processing system can perform multiple different types of detection, thereby providing improved flexibility and better accuracy in processing samples. The detection systems in the sample processing system may include an optical detection system and a mass spectrometer.
    Type: Grant
    Filed: May 22, 2018
    Date of Patent: August 2, 2022
    Assignee: Beckman Coulter, Inc.
    Inventors: Aaron Hudson, Takayuki Mizutani, Subhasish Purkayastha, Thomas W. Roscoe
  • Patent number: 11402307
    Abstract: A method for concentrating at least one analyte including the following steps: preparing a first phase including at least one analyte; depositing a drop of the first phase on a substrate; depositing on the drop of first phase a drop of a second liquid phase including at least one surfactant, the second phase being non-miscible with the first phase; evaporating the drop of the second phase; and evaporating the drop of the first phase. Also relates to a method for detecting at least one analyte using the concentration method; and a system using the detection method.
    Type: Grant
    Filed: October 6, 2017
    Date of Patent: August 2, 2022
    Assignee: COMMISSARIAT À L'ÉNERGIE ATOMIQUE ET AUX ÉNERGIES ALTERNATIVES (CEA)
    Inventors: Florent Malloggi, Kiarach Mesbah, Sarah Bregant
  • Patent number: 11391681
    Abstract: Methods and devices for mass spectrometry are described, specifically the use of nanoparticulate implantation as a matrix for secondary ion and more generally secondary particles. A photon beam source or a nanoparticulate beam source can be used a desorption source or a primary ion/primary particle source.
    Type: Grant
    Filed: December 21, 2020
    Date of Patent: July 19, 2022
    Assignee: Ionwerks, Inc.
    Inventors: J. Albert Schultz, Thomas F. Egan, Ernest K. Lewis, Steven Ulrich, Kelley L. Waters
  • Patent number: 11393666
    Abstract: A system comprises: first and second mass spectrometers; at least one liquid chromatograph configured to simultaneously supply a first stream of chromatographic eluate derived from a sample to the first mass spectrometer and a second stream of chromatographic eluate to the second mass spectrometer; and a computer or electronic controller electronically coupled to both of the first and second mass spectrometers and comprising computer-readable instructions operable to: input a mass spectrometric analysis of a chromatographic fraction of the sample obtained by the first mass spectrometer; determine whether an additional mass spectrometric analysis of the chromatographic fraction of the sample is required, based on the mass spectrometric analysis of the chromatographic fraction obtained by the first mass spectrometer; and, if the determination is affirmative, cause the second mass spectrometer to perform, after a time delay, the additional mass spectrometric analysis of the chromatographic fraction of the sample
    Type: Grant
    Filed: December 19, 2019
    Date of Patent: July 19, 2022
    Assignee: THERMO FINNIGAN LLC
    Inventor: Bennett S. Kalafut
  • Patent number: 11387089
    Abstract: A direct sample introduction device includes: a pre-evacuating chamber that has an internal space extending in a first direction through which a sample introduction probe extends in the first direction; a first ventilation unit that is allowed to be opened and closed, with a first end thereof being connected to the pre-evacuating chamber; and a second ventilation unit a first end of which is connected to the pre-evacuating chamber and a second end of which is connected to a low pressure source.
    Type: Grant
    Filed: November 19, 2020
    Date of Patent: July 12, 2022
    Assignee: SHIMADZU CORPORATION
    Inventor: Yoshiro Hiramatsu
  • Patent number: 11387092
    Abstract: The disclosure provides a thermal desorption (TD) tube sampler. The sampler comprises a first connector configured to reversibly connect to a TD tube containing a sample, and a second connector configured to couple to a direct injection mass spectrometer. The TD tube sampler is configured to desorb a sample in a TD tube connected thereto, and feed the desorbed sample from the TD tube to a direct injection mass spectrometer such that the desorbed sample does not pass through a cold trap.
    Type: Grant
    Filed: July 2, 2019
    Date of Patent: July 12, 2022
    Assignee: IP2IPO INNOVATIONS LIMITED
    Inventors: George Hanna, Andrea Romano
  • Patent number: 11387094
    Abstract: A time-of-flight (ToF) mass spectrometer, comprising: a pulsed ion injector for forming an ion beam that travels along an ion path; a detector for detecting ions in the ion beam that arrive at the detector at times according to their m/z values; an ion focusing arrangement located between the ion injector and the detector for focusing the ion beam in at least one direction orthogonal to the ion path; and a variable voltage supply for supplying the ion focusing arrangement with at least one variable voltage that is dependent on a charge state and/or an amount of ions of at least one species of ions in the ion beam. A corresponding method of mass spectrometry is provided. The charge state and/or an amount of ions may be acquired from a pre-scan, or predicted. Tuning of the spectrometer based on a charge state and/or an amount of ions of at least one species of ions in the ion beam may be performed on the fly.
    Type: Grant
    Filed: March 2, 2021
    Date of Patent: July 12, 2022
    Assignee: Thermo Fisher Scientific (Bremen) GmbH
    Inventors: Hamish Stewart, Dmitry E. Grinfeld, Alexander A. Makarov
  • Patent number: 11380531
    Abstract: A method of operating a mass spectrometer that allows for high-speed operation is disclosed. The method consists in separating the various steps needed to produce a mass spectrum into three or more conceptual stages in a pipeline, such that the instrument is performing steps to process more than two precursor-ion species simultaneously. In general, the number of stages in the pipeline should at least one more and, preferably, at least two more than the number of buffering storage devices in the instrument. The presently-taught methods and apparatus allow for nearly 100% duty cycle of ion accumulation for precursors of interest.
    Type: Grant
    Filed: November 8, 2019
    Date of Patent: July 5, 2022
    Assignee: THERMO FINNIGAN LLC
    Inventors: Michael W. Senko, Philip M. Remes
  • Patent number: 11379974
    Abstract: An electrophoretic separation data analyzing apparatus includes an analysis target peak identifying part configured to require a user to input analysis target peak information on analysis target peaks to be added to an analysis target in separation data obtained by electrophoretic separation, and to identify at least one of the analysis target peaks based on the analysis target peak information, a peak-of-interest identifying part configured to require the user to input peak-of-interest information on a peak of interest among the analysis target peaks, and identify the peak of interest based on the peak-of-interest information, and an abundance ratio calculating part configured to determine an abundance ratio of the peak of interest among all of the analysis target peaks based on a total value of peak areas of the analysis target peaks and a peak area value of the peak of interest.
    Type: Grant
    Filed: July 8, 2019
    Date of Patent: July 5, 2022
    Assignee: SHIMADZU CORPORATION
    Inventors: Hidesato Kumagai, Akira Harada, Kota Ogino
  • Patent number: 11371971
    Abstract: Disclosed are methods for improving compound detection and characterization. Methods for characterizing a sample are disclosed. The methods can include providing a sample to a liquid chromatography system capable of sample separation to generate sample components; analyzing sample components by multiplexed targeted selected ion monitoring (SIM) to generate an inclusion list; and performing iterative mass spectral data-dependent acquisition (DDA) from the inclusion list, to identify individual sample components thereby characterizing the sample. In one example, multiplexed targeted SIMs and iterative MS2 DDA acquisition is used to increase robust compound identification for cell culture medium analysis.
    Type: Grant
    Filed: January 29, 2021
    Date of Patent: June 28, 2022
    Assignee: Regeneron Pharmaceuticals, Inc.
    Inventors: Jikang Wu, Hongxia Wang, Haibo Qiu, Ning Li
  • Patent number: 11367607
    Abstract: A drive unit for driving an acceleration electrode of a mass spectrometer is disclosed. The drive unit includes a power converter comprising a switching element and pulsing circuitry that can form output pulses suitable for driving an acceleration electrode of a mass spectrometer. The drive unit also includes a controller that is configured to synchronise operation of the switching element with the pulsing circuitry.
    Type: Grant
    Filed: May 31, 2019
    Date of Patent: June 21, 2022
    Assignee: Micromass UK Limited
    Inventors: Frank Buckley, Roger Smith
  • Patent number: 11355336
    Abstract: A method of performing time-of-flight secondary ion mass spectrometry on a sample includes the step of directing a beam of primary ions to the sample, and stimulating the migration of ions within the sample while the beam of primary ions is directed at the sample. The stimulation of the ions is cycled between a stimulation state and a lower stimulation state. Secondary ions emitted from the sample by the beam of primary ions are collected in a time-of-flight mass spectrometer. Time-of-flight secondary ion mass spectrometry is then performed on the secondary ions. A system for performing time-of-flight secondary ion mass spectrometry on a sample is also disclosed.
    Type: Grant
    Filed: February 12, 2021
    Date of Patent: June 7, 2022
    Assignees: UT-BATTELLE, LLC, UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION
    Inventors: Anton V. Ievlev, Olga S. Ovchinnikova, Matthias Lorenz, Yongtao Liu
  • Patent number: 11346845
    Abstract: Methods are described for measuring the amount of C peptide in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying C peptide in a sample utilizing on-line extraction methods coupled with tandem mass spectrometric or high resolution/high accuracy mass spectrometric techniques.
    Type: Grant
    Filed: September 21, 2020
    Date of Patent: May 31, 2022
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Nigel Clarke, Zhaohui Chen
  • Patent number: 11342170
    Abstract: An apparatus for performing ambient ionization mass and/or ion mobility spectrometry is disclosed. The apparatus comprises a substantially cylindrical, tubular, rod-shaped, coil-shaped, helical or spiral-shaped collision assembly; and a first device arranged and adapted to direct analyte, smoke, fumes, liquid, gas, surgical smoke, aerosol or vapor onto said collision assembly.
    Type: Grant
    Filed: March 7, 2016
    Date of Patent: May 24, 2022
    Assignee: Micromass UK Limited
    Inventors: Tamas Karancsi, Daniel Simon, Lajos Godorhazy, Daniel Szalay, Steven Derek Pringle, Emrys Jones, Ian Trivett, Stephen O'Brien, Anthony Hesse, Matt Henderson, Alvin Chua, Zoltan Takats
  • Patent number: 11342155
    Abstract: In a charged particle beam device including a deceleration optical system, a change in a deceleration electric field and an axis shift due to a structure between an objective lens and a sample are prevented to reduce adverse effects on an irradiation system and detection system. The charged particle beam device includes an electron source, an objective lens configured to focus a probe electron beam from the electron source on the sample, an acceleration electrode configured to accelerate the probe electron beam, a first detector provided in the acceleration electrode, a deceleration electrode configured to form a deceleration electric field for the probe electron beam with the acceleration electrode, the probe electron beam being configured to pass through an opening of the deceleration electrode, and a second detector inserted between the deceleration electrode and the sample.
    Type: Grant
    Filed: May 22, 2018
    Date of Patent: May 24, 2022
    Assignee: Hitachi High-Tech Corporation
    Inventors: Yuta Imai, Masahiro Sasajima, Yoshihiro Takahoko
  • Patent number: 11342169
    Abstract: In one embodiment, a power source for providing high-voltage radio-frequency (RF) energy to an instrument such as a mass spectrometer includes an RF power amplifier having an output, an oscillating RF signal generator configured to provide first and second RF signals respectively oscillating at first and second frequencies to the RF power amplifier, and a step-up circuit for magnifying the RF power amplifier output. The step-up circuit includes an LC resonator network tuned to the first and second frequencies, and an output for providing the magnified voltage to a rod assembly of the mass spectrometer.
    Type: Grant
    Filed: April 8, 2020
    Date of Patent: May 24, 2022
    Assignee: AGILENT TECHNOLOGIES, INC.
    Inventor: Michael Schoessow
  • Patent number: 11322340
    Abstract: Disclosed is an ion carousel having a first surface and a second surface adjacent to the first surface. The second surface includes a first inner array of electrodes arranged along a first loop path and configured to receive a first ion packet and a second ion packet temporally separated from the first ion packet by a separation time. The first inner array of electrodes generates a traveling waveform which includes a plurality of potential wells that travel along the first loop path and receive ions from the first and second ion packets. The plurality of potential wells include at least a first potential well and a second potential well. An output switch is configured to selectively eject ions from the first potential well out of the carousel at time T1 and eject ions from the second potential well out of the carousel at time T2.
    Type: Grant
    Filed: August 7, 2020
    Date of Patent: May 3, 2022
    Assignee: MOBILion Systems, Inc.
    Inventors: Ahmed M. Hamid, John Daniel DeBord, Gordon A. Anderson
  • Patent number: 11322341
    Abstract: The probe drive unit (21) collects a sample (8) at the tip of the probe (6) by lowering and raising the probe (6) under the control of the control unit (25). After that, the high voltage generating unit (20) applies a high voltage whose voltage value increases in a slope shape to the probe (6), and meanwhile, the mass spectrometry unit behind the capillary tube (10) performs product ion scan measurements on the two-step probe voltage, and the mass spectrum data obtained in each measurement is stored in the first and the second probe voltage corresponding data storage units (301 and 302). When the ionization efficiencies of the plurality of types of components contained in the sample (8) have a probe voltage dependence, ion peaks derived from different types of components appear in the two mass spectra.
    Type: Grant
    Filed: May 31, 2018
    Date of Patent: May 3, 2022
    Assignee: SHIMADZU CORPORATION
    Inventor: Tasuku Murata
  • Patent number: 11313833
    Abstract: A chemical trace detection system includes: a drift tube; a detector disposed within the drift tube; a voltage source to produce an electrical field in the drift tube; an ionizer to establish an ionization region adjacent to the electrical field; and a desorber including a sample holder to hold a sample in or adjacent to the ionization region and a sample heater to desorb particles of the sample held in the sample holder such that the desorbed particles are introduced directly into the ionization region from the sample holder to form ionized particles that are forced toward the detector by the electrical field. A regenerable dryer assembly for supplying dry drift gas to an ion mobility spectrometer is also provided that includes a regenerable desiccant material.
    Type: Grant
    Filed: August 31, 2018
    Date of Patent: April 26, 2022
    Assignee: Leidos Security Detection & Automation, Inc.
    Inventors: Hacene Boudries, Troy Velazquez, Anatoly Lazarevich, Dmitriy Ivashin, Andrew Anderson
  • Patent number: 11313866
    Abstract: A method for in vitro diagnosing asphyxia and disorders related thereto, a method of in vitro estimating duration of hypoxia in a patient subjected to asphyxia, and a method for in vitro monitoring of normoxic, hypoxic and hyperoxic conditions and/or normobaric and hyperbaric oxygen therapy, includes quantitatively detecting in a biological sample of a patient a plurality of asphyxia specific endogenous compounds which are selected from the group consisting of biogenic amines; carnitine-derived compounds; amino acids; bile acids; carboxylic acids; eicosanoids; lipids; precursors of cholesterol, cholesterol metabolites; prostanoids; and sugars.
    Type: Grant
    Filed: September 11, 2017
    Date of Patent: April 26, 2022
    Assignee: InfanDx AG
    Inventors: Matthias Keller, Hans-Peter Deigner, David Enot, Matthias Kohl, Ronnaug Solberg, Olga Saugstad, Therese Koal
  • Patent number: 11315781
    Abstract: A sampling period of an A/D converter is set in accordance with an ion pulse ejection operation of a collision cell of an accumulation type. Start timing of the sampling period is changed in accordance with a selected m/z of a second mass analysis unit. In addition, end timing of the sampling period may be changed in accordance with the selected m/z of the second mass analysis unit. In place of the sampling period, a data cut-out period may be changed.
    Type: Grant
    Filed: December 3, 2020
    Date of Patent: April 26, 2022
    Assignee: JEOL Ltd.
    Inventors: Masatoshi Fujii, Junkei Kou
  • Patent number: 11300559
    Abstract: Methods are described for measuring the amount of a vitamin B2 in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying vitamin B2 in a sample utilizing on-line extraction methods coupled with tandem mass spectrometric techniques.
    Type: Grant
    Filed: February 14, 2020
    Date of Patent: April 12, 2022
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Changming Yang, Sum Chan
  • Patent number: 11300542
    Abstract: The present disclosure describes an improved sample preparation technique and adapter device for the removal of trace materials from swabs and delivery of the trace materials into a mass spectrometer (MS) or an ion mobility spectrometer (IMS). The adapter device and technique aids the delivery of the analyte into the instrument inlet and concurrently serves as an ionization source. The technique includes the steps of positioning or shaping the swab so that a pointed analyte release corner or tip is directed toward the inlet of the MS or IMS, adding a solvent to the swab and charging the swab to create an ionized analyte spray pointed at or positioned within the inlet of the detection instrument.
    Type: Grant
    Filed: February 28, 2020
    Date of Patent: April 12, 2022
    Assignee: University of Rhode Island Board of Trustees
    Inventors: Jimmie Oxley, James L. Smith, Alexander Yevdokimov, Gerald Kagan
  • Patent number: 11295833
    Abstract: A mass isolation device selects a precursor ion of a sample that has been digested using a protease. A first fragmentation device fragments the precursor ion using collision-induced dissociation (CID), and the resulting product ions are analyzed using a mass analyzer producing a CID spectrum. A list of theoretical candidate glycopeptide sequences is determined from CID spectrum. The mass isolation device again selects the precursor ion of the sample. A second fragmentation device fragments the precursor ion using electron-based dissociation (ExD), and the resulting product ions are analyzed using the mass analyzer producing a CID spectrum. For each sequence of the list, the sequence is computationally fragmented, producing theoretical fragments, mass-to-charge ratio (m/z) values are calculated for the theoretical fragments, and the sequence is scored using c and z fragment matching rules. The highest scoring sequence is identified as a peptide sequence of a glycopeptide of the sample.
    Type: Grant
    Filed: March 19, 2019
    Date of Patent: April 5, 2022
    Assignee: DH Technologies Development Pte. Ltd.
    Inventor: Takashi Baba
  • Patent number: 11295939
    Abstract: An analytical device includes: a reaction unit into which an ion derived from a sample component is introduced; a radical generation unit that generates a radical by vacuum discharge and comprises a raw material introduction chamber into which a plasma raw material is introduced; a connection part that introduces the radical generated in the radical generation unit into a vacuum chamber, the vacuum chamber having a pressure lower than a pressure of the raw material introduction chamber and being connected to the reaction unit; and a separation unit that separates a generated ion generated by a reaction with the radical introduced via the connection part into the reaction unit according to m/z and/or ion mobility, wherein an inner diameter of a cross section of the connection part is equal to or less than 20 millimeters.
    Type: Grant
    Filed: April 25, 2019
    Date of Patent: April 5, 2022
    Assignees: SHIMADZU CORPORATION, THE DOSHISHA
    Inventors: Hidenori Takahashi, Motoi Wada, Yuji Shimabukuro
  • Patent number: 11295942
    Abstract: An apparatus for performing ambient ionization mass and/or ion mobility spectrometry is disclosed. The apparatus comprises a substantially cylindrical, tubular, rod-shaped, coil-shaped, helical or spiral-shaped collision assembly; and a first device arranged and adapted to direct analyte, smoke, fumes, liquid, gas, surgical smoke, aerosol or vapor onto said collision assembly.
    Type: Grant
    Filed: March 7, 2016
    Date of Patent: April 5, 2022
    Assignee: Micromass UK Limited
    Inventors: Tamas Karancsi, Daniel Simon, Lajos Godorhazy, Daniel Szalay, Steven Derek Pringle, Emrys Jones, Ian Trivett, Stephen O'Brien, Anthony Hesse, Matt Henderson, Alvin Chua, Zoltan Takats
  • Patent number: 11295940
    Abstract: A method for deconvoluting measured mass spectrometry data, the method comprising: receiving measured mass spectrometry data representing at least two molecular moieties each having a respective isotopic pattern, wherein at least two of said isotopic patterns overlap; iteratively filling a set of mass channels to produce an approximated version of the mass spectrometry data, said iterative filling comprising a number of iterations, each iteration comprising filling one or more of the mass channels with a chunk of intensity data according to the isotopic pattern of a respective one of the two or more molecular moieties selected for said iteration; terminating said iterative filling when a fitness criterion is met indicating a fit of the approximated version of the mass spectrometry data to the measured mass spectrometry data; and determining the amount of each molecular moiety that produced the measured mass spectrometry data based on the total amount of fills according to the respective isotopic pattern of sa
    Type: Grant
    Filed: May 27, 2020
    Date of Patent: April 5, 2022
    Assignee: Thermo Fisher Scientific (Bremen) GmbH
    Inventors: Frank Berg, Robert Malek, Kai Fritzemeier
  • Patent number: 11288795
    Abstract: The subject disclosure presents systems and computer-implemented methods for assessing a risk of cancer recurrence in a patient based on a holistic integration of large amounts of prognostic information for said patient into a single comparative prognostic dataset. A risk classification system may be trained using the large amounts of information from a cohort of training slides from several patients, along with survival data for said patients. For example, a machine-learning-based binary classifier in the risk classification system may be trained using a set of granular image features computed from a plurality of slides corresponding to several cancer patients whose survival information is known and input into the system. The trained classifier may be used to classify image features from one or more test patients into a low-risk or high-risk group.
    Type: Grant
    Filed: October 21, 2019
    Date of Patent: March 29, 2022
    Assignee: Ventana Medical Systems, Inc.
    Inventors: Michael Barnes, Srinivas Chukka, David Knowles
  • Patent number: 11289317
    Abstract: This invention relates to graphical user-interactive analysis of data, including in particular, mass spectrographic data analysis, as well as methods and software for generating and using such. One aspect provides user-customizable reports, including methods and apparatuses for generating customizable pivot tables and graphs specific to mass spectrographic data.
    Type: Grant
    Filed: December 28, 2020
    Date of Patent: March 29, 2022
    Assignee: Protein Metrics Inc.
    Inventors: Yong Joo Kil, Eric Carlson
  • Patent number: 11282686
    Abstract: A user enters structures of a plurality of metabolite candidates contained in a sample. A dissociation pattern predictor predicts a dissociation pattern for each metabolite candidate. An MS/MS spectrum estimator estimates an MS/MS spectrum and stores it in a teaching data storage. An imaging mass spectrometry unit acquires measured MS/MS spectra for each measurement point within a measurement range on a sample by performing an MS/MS analysis in which a precursor ion based on mass information of each metabolite candidate is used as an analysis target. A multivariate analysis processor performs a multivariate analysis in which the peak information based on the MS/MS spectra stored in the teaching data storage is used as teaching data, to classify measured MS/MS spectra at each measurement point into a plurality of metabolite candidates. Based on the classification result, a spatial distribution creator creates an image showing a spatial distribution for each metabolite candidate.
    Type: Grant
    Filed: February 5, 2018
    Date of Patent: March 22, 2022
    Assignee: SHIMADZU CORPORATION
    Inventor: Shinichi Yamaguchi
  • Patent number: 11282683
    Abstract: A reference image data input section reads, from a Raman spectroscopic analyzer, a set of data constituting a Raman spectroscopic imaging graphic for a target sample. An ROI specification processor) displays a Raman spectroscopic imaging graphic based on those data on a display unit. An operator viewing the image operates an input unit to set a plurality of ROIs. Then, the ROI specification processor determines position information of the ROIs. An analysis processor extracts the data of measurement points corresponding to the set ROIs from MS imaging data acquired by an analysis performed by an imaging mass spectrometry unit for the same target sample. The processor also calculates an average mass spectrum from the data of a large number of measurement points for each ROI, and performs a multivariate analysis on the plurality of average mass spectrum data to compare the ROIs with each other or divide them into groups.
    Type: Grant
    Filed: February 5, 2018
    Date of Patent: March 22, 2022
    Assignee: SHIMADZU CORPORATION
    Inventor: Shinichi Yamaguchi
  • Patent number: 11275054
    Abstract: An ion mass spectrometer that has an ion channel shaped to modify the speed of a carrier gas as the carrier gas traverses the ion channel. In one case, the ion channel has segments of constant diameter in which the speed of the flowing gas is constant but different than the speed in other segments of the ion channel. This controlled variation in speed from segment to segment, together with the control of the axial electric field in the ion channel, provide greater control on the separation of ions in the ion channel. A method of analyzing ions based on a variation of at least one of axial electric field and of the speed of the flowing gas in the ion channel is also disclosed.
    Type: Grant
    Filed: February 13, 2019
    Date of Patent: March 15, 2022
    Assignee: JP SCIENTIFIC LIMITED
    Inventors: Scott Hopkins, Janusz B. Pawliszyn
  • Patent number: 11266999
    Abstract: According to one embodiment, a dust-collecting apparatus includes a main body with a first surface on which a back surface of a first electrode is disposed; a fixing unit configured to control attachment and detachment of the first electrode and the main body; a second electrode configured to transfer a voltage to the first electrode; and a control board configured to control a magnitude and a timing of a voltage which is applied to the second electrode.
    Type: Grant
    Filed: November 1, 2018
    Date of Patent: March 8, 2022
    Assignee: NuFlare Technology, Inc.
    Inventors: Yosuke Takahashi, Yuji Abe, Kiminobu Akeno
  • Patent number: 11270875
    Abstract: A power supply device includes a power supply circuit, a casing, a mold resin and a grounding member. The casing is conductive. At least part of a circuit portion of the power supply circuit is stored in the casing. A resin injector is formed in the casing. A mold resin is injected from the resin injector to fill the casing and enclose the circuit portion. The grounding member is conductive. The grounding member is arranged in the casing to shield the resin injector from the circuit portion while being in contact with the mold resin.
    Type: Grant
    Filed: April 17, 2019
    Date of Patent: March 8, 2022
    Assignee: SHIMADZU CORPORATION
    Inventors: Takuro Kishida, Yasushi Aoki
  • Patent number: 11262331
    Abstract: An ion filter for filtering ions in a gas sample. The ion filter has a first ion channel for filtering ions from a target chemical in the gas sample. The ion filter has a second ion channel for filtering ions from the target chemical in the gas sample. The second ion channel is separated from the first ion channel. A temperature control region is in thermal contact with the first and second ion channels for controlling a difference in temperature between the first and second ion channels. A method of filtering ions from a target chemical in a gas sample is also provided.
    Type: Grant
    Filed: September 10, 2018
    Date of Patent: March 1, 2022
    Assignees: Owlstone Medical Limited, Owlstone Inc.
    Inventors: Daniel Melhirst, Jonathan Pearson, Max Allsworth
  • Patent number: 11264223
    Abstract: A method is disclosed comprising providing a biological sample on a swab, directing a spray of charged droplets onto a surface of the swab in order to generate a plurality of analyte ions, and analysing the analyte ions.
    Type: Grant
    Filed: July 12, 2018
    Date of Patent: March 1, 2022
    Assignee: Micromass UK Limited
    Inventors: Zoltan Takats, Emrys Jones, James Ian Langridge, Michael Raymond Morris, Tamas Karancsi, Steven Derek Pringle, Julia Balog, Daniel Simon, Lajos Godorhazy, Daniel Szalay, Keith Richardson, Phillip Robert Bennett, David Alan Macintyre, Pamela Pruski
  • Patent number: 11255866
    Abstract: Provided herein are reagents, methods and biochemical markers for identifying individuals with glucoregulatory dysfunction and providing therapeutic intervention for individuals identified as at risk for glucoregulatory dysfunction. Specifically provided herein are methods for identifying a subject with glucoregulatory dysfunction based on changes in fasting blood lipid concentrations including, inter alia, diacylglycerols.
    Type: Grant
    Filed: February 25, 2016
    Date of Patent: February 22, 2022
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Rozalyn M. Anderson, Dhanansayan Shanmuganayagam, Ricki L. Colman, James Mukasa Ntambi, Mary J. Lindstrom, Michael A. Polewski, Maggie S. Burhans
  • Patent number: 11255818
    Abstract: The present invention provides a method for relative quantitative analysis of a polymer using MALDI mass spectrometry, the method comprising the steps of: (S1) electro-spraying a solution containing a polymer sample and a matrix through a mask to prepare a plurality of polymer specimens with a thickness variation of 30% or less according to the concentration of the polymer sample; (S2) irradiating the respective plurality of polymer specimens with laser to obtain MALDI mass spectra; and (S3) creating a quantitative calibration curve from peak results of the MALDI mass spectra by using a signal of the polymer sample.
    Type: Grant
    Filed: July 12, 2019
    Date of Patent: February 22, 2022
    Inventors: Kyoungjoo Jin, Yongjin Bae, Young Hee Lim, Yeu Young Youn
  • Patent number: 11255779
    Abstract: The present invention provides a method for the quantitative determination of contaminants in the form of fatty acid esters in jet fuels, wherein the analyte is the fatty acid ester fatty acid methyl ester (FAME) and/or the fatty acid ester fatty acid ethyl ester (FAEE), wherein the analyte undergoes a chemical reaction which is selective for it and which influences the intensity for the carbonyl band of the respective ester group with the formation of a modified analyte and the variation in the concentration of analyte in the sample, which is the jet fuel together with FAME and/or FAEE, is measured using the reduction in the intensity of the carbonyl band and/or the increase in the concentration of the modified analyte is measured using the increase in the intensity of a band which is characteristic for the modification.
    Type: Grant
    Filed: July 25, 2018
    Date of Patent: February 22, 2022
    Assignee: Quantared Technologies GmbH
    Inventors: Wolfgang Ritter, Bernhard Lendl
  • Patent number: 11251030
    Abstract: An object of the invention is to provide a mass spectrometry apparatus capable of obtaining a highly accurate quantitative result and being low-cost. A small section measurement instruction unit 101 instructs a detector 9 to perform measurement on a plurality of small sections 5 in a channel 4, the signals detected by the detector 9 are stored in a data storage unit 102, the signals are integrated by a small section signal amount integration unit 103, and variance of the integrated signals is calculated by a signal variance calculation unit 104. A signal variance evaluation unit 105 evaluates the signal variance of signals of each small section 5 in the same channel 4. When the signal variance is evaluated to be stable, an operation control unit 106 controls operations of the ion source 6 to continue measurement without warning. When the signal variance is evaluated to be unstable, the warning is performed during the measurement or after the measurement.
    Type: Grant
    Filed: July 24, 2019
    Date of Patent: February 15, 2022
    Assignee: Hitachi High-Tech Corporation
    Inventor: Yuichiro Hashimoto
  • Patent number: 11239067
    Abstract: Improved ion mirrors (30) (FIG. 3) are proposed for multi-reflecting TOF MS and electrostatic traps. Minor and controlled variation by means of arranging a localized wedge field structure (35) at the ion retarding region was found to produce major tilt of ion packets time fronts (39). Combining wedge reflecting fields with compensated deflectors is proposed for electrically controlled compensation of local and global misalignments, for improved ion injection and for reversing ion motion in the drift direction. Fine ion optical properties of methods and embodiments are verified in ion optical simulations.
    Type: Grant
    Filed: July 26, 2018
    Date of Patent: February 1, 2022
    Assignee: Micromass UK Limited
    Inventors: Anatoly Verenchikov, Mikhail Yavor
  • Patent number: 11239068
    Abstract: Systems and methods for controlling mass filtering of polyatomic ions in an ion beam passing through an inductively coupled plasma mass spectrometer (ICP-MS). Polyatomic ion mass data representative of the exact mass of a polyatomic ion having a target isotope is determined. A control signal is generated based on the determined polyatomic ion mass data and output to an ICP-MS to filter based on mass the polyatomic ions in the ion beam traveling through the ICP-MS to an ion detector.
    Type: Grant
    Filed: August 20, 2019
    Date of Patent: February 1, 2022
    Assignee: Agilent Technologies, Inc.
    Inventors: Naoki Sugiyama, Amir Liba, Mark Lee Kelinske, Glenn David Woods
  • Patent number: 11229911
    Abstract: Various aspects of the present invention relate to the control and manipulation of fluidic species, for example, in microfluidic systems. In one set of embodiments, droplets may be sorted using surface acoustic waves. The droplets may contain cells or other species. In some cases, the surface acoustic waves may be created using a surface acoustic wave generator such as an interdigitated transducer, and/or a material such as a piezoelectric substrate. The piezoelectric substrate may be isolated from the microfluidic substrate except at or proximate the location where the droplets are sorted, e.g., into first or second microfluidic channels. At such locations, the microfluidic substrate may be coupled to the piezoelectric substrate (or other material) by one or more coupling regions. In some cases, relatively high sorting rates may be achieved, e.g., at rates of at least about 1,000 Hz, at least about 10,000 Hz, or at least about 100,000 Hz, and in some embodiments, with high cell viability after sorting.
    Type: Grant
    Filed: January 2, 2019
    Date of Patent: January 25, 2022
    Assignees: President and Fellows of Harvard College, Universität Augsburg
    Inventors: David A. Weitz, Thomas Franke, Achim Wixforth, Lothar Schmid, Jeremy Agresti, Adam R. Abate
  • Patent number: 11227753
    Abstract: System for quantifying a composition of a target sample based on a scan output of a first type of sensor includes a reference database, a custom database and a set of modules. The set of modules includes an analytical model creation module that creates an analytical model of the first type of sensor, a sample processing module that processes samples that include accurately known compositions using the first type of sensor under a standard pressure condition, a molecular fraction estimation module that estimates molecular fraction of the samples using an estimation method and the analytical model, an analytical model optimization module that optimizes the analytical model by comparing the molecular fraction of the samples with a pre-determined molecular fraction of the samples, and a target composition estimation module that estimates a composition of the target sample based on the scan output using the estimation method with the optimized analytical model.
    Type: Grant
    Filed: October 4, 2017
    Date of Patent: January 18, 2022
    Assignee: ATONARP INC.
    Inventor: Karthikeyan Rajan Madathil