With Collection Of Ions Patents (Class 250/283)
  • Patent number: 10446384
    Abstract: A quadrupole is filled with ions and the ions are cooled by applying a pressure and gas flow within the quadrupole. Ions are trapped in the quadrupole by applying a DC voltage and an RF voltage to quadrupole rods of the quadrupole, one or more DC voltages to a plurality of auxiliary electrodes of the quadrupole, and a DC voltage and an RF voltage to an exit lens at the end of the quadrupole. The ions are coherently oscillated after the filling and cooling by applying a coherent excitation between at least two rods of the quadrupole rods. The coherently oscillating ions are axially ejected through the exit lens and to a destructive detector for detection by changing one or more voltages of the one or more DC voltages of the plurality of auxiliary electrodes and changing the DC voltage of the exit lens.
    Type: Grant
    Filed: April 19, 2016
    Date of Patent: October 15, 2019
    Assignee: DH Technologies Development Pte. Ltd.
    Inventor: James Walter Hager
  • Patent number: 10420495
    Abstract: The invention generally relates to enclosed desorption electrospray ionization probes, systems, and methods. In certain embodiments, the invention provides a source of DESI-active spray, in which a distal portion of the source is enclosed within a transfer member such that the DESI-active spray is produced within the transfer member.
    Type: Grant
    Filed: January 15, 2019
    Date of Patent: September 24, 2019
    Assignee: PURDUE RESEARCH FOUNDATION
    Inventors: Robert Graham Cooks, Zheng Ouyang, Chien-hsun Chen, Ziqing Lin, Livia Schiavinato Eberlin
  • Patent number: 10424473
    Abstract: A miniature mass spectrometer is disclosed comprising an atmospheric pressure ionization source, a first vacuum chamber having an atmospheric pressure sampling orifice or capillary, a second vacuum chamber located downstream of the first vacuum chamber and a third vacuum chamber located downstream of the second vacuum chamber. A first vacuum pump is arranged and adapted to pump the first vacuum chamber, wherein the first vacuum pump is arranged and adapted to maintain the first vacuum chamber at a pressure <10 mbar. A first RF ion guide is located within the first vacuum chamber and an ion detector is located in the third vacuum chamber. The ion path length from the atmospheric pressure sampling orifice or capillary to an ion detecting surface of the ion detector is ?400 mm.
    Type: Grant
    Filed: August 21, 2018
    Date of Patent: September 24, 2019
    Assignee: Micromass UK Limited
    Inventors: David Gordon, Daniel James Kenny
  • Patent number: 10410849
    Abstract: Systems and methods described herein utilize an ion guide for use in mass spectrometer systems, which ion guide can receive ions from an ion source for transmission to downstream mass analyzers, while preventing debris (e.g., unsolvated droplets, neutral molecules, heavy charged clusters) from being transmitted into a high-vacuum chamber of the mass spectrometer system. In various aspects, systems and methods in accordance with the present teachings can increase throughput, improve the robustness of the system, and/or decrease the downtime typically required to disassemble/clean sensitive components within the high-vacuum portions of the mass spectrometer system.
    Type: Grant
    Filed: March 22, 2016
    Date of Patent: September 10, 2019
    Assignee: DH Technologies Development Pte. Ltd.
    Inventor: Mircea Guna
  • Patent number: 10395909
    Abstract: The objective of the present invention is to obtain an MS2 spectrum for each of a plurality of different ion species even when their m/z values are extremely close to each other and prevent separate setting of each ion species as the precursor ion. In the vicinity of the target m/z, a precursor-ion selection window covering a predetermined m/z range (2×?M) is gradually shifted in predetermined steps (?m) to define a plurality of windows as the condition of the precursor-ion selection. When an MS2 analysis is performed on the same sample for each window, the intensities of the product-ion peaks which appear on the MS2 spectrum change with the change in the central m/z value of the window. From this intensity change, which of the plurality of ion species selected as the precursor ion is the origin of each product ion is determined. Based on the result of this determination, the product ions are sorted out and an MS2 spectrum is reconstructed for each ion species.
    Type: Grant
    Filed: January 16, 2014
    Date of Patent: August 27, 2019
    Assignee: SHIMADZU CORPORATION
    Inventor: Shinichi Yamaguchi
  • Patent number: 10365245
    Abstract: The invention relates to a gating element for switching or modulating the ion current in ion mobility spectrometers, particularly in miniature ion mobility spectrometers (IMS) operated at atmospheric pressure, where the ion current of an ion source is modulated with a continuous modulation function and the mobility spectrum is generated from the measured ion current by a correlation analysis with the modulation pattern. The invention proposes using a layered plate with apertures (apertured plate) rather than a grid (or a series of grids), said apertured plate comprising at least three conductive and two insulating (or low-conductivity) layers arranged alternately, which are firmly bonded with each other.
    Type: Grant
    Filed: December 19, 2017
    Date of Patent: July 30, 2019
    Inventor: Uwe Renner
  • Patent number: 10290485
    Abstract: Methods and systems for analyzing ions in a magnetic ion trap are provided herein. In accordance with various aspects of the present teachings, the methods and systems described herein enable Fourier transform ion cyclotron resonance mass spectrometry across relatively narrow gap magnetic fields substantially perpendicular to the axis along which the ions are injected into the ion trap. As a result, smaller, less expensive magnets can be used to produce the high-intensity, uniform magnetic fields utilized in high performance FT-ICR/MS applications. Accordingly, the present teachings enable permanent magnets (as well as electromagnets) to generate these magnetic fields, potentially reducing the cost, size, and/or complexity of the systems described herein relative to conventional FT-ICR systems.
    Type: Grant
    Filed: November 24, 2015
    Date of Patent: May 14, 2019
    Assignee: DH Technologies Development Pte. Ltd.
    Inventors: Takashi Baba, Alex Berlyand
  • Patent number: 10269549
    Abstract: A time of flight (“TOF”) mass spectrometer including an ion source, a detector, and a tilt correction device. The ion source is configured to produce ions having a plurality of m/z values. The detector detects ions produced by the ion source. The tilt correction device is located along a portion of a reference ion flight path extending from the ion source to a planar surface of the detector and includes tilt correction electrodes configured to generate at least one dipole electric field across the reference ion flight path. The at least one dipole electric field is configured to tilt an isochronous plane of ions produced by the ion source so as to correct a previous angular misalignment between the isochronous plane and the planar surface of the detector.
    Type: Grant
    Filed: September 27, 2016
    Date of Patent: April 23, 2019
    Assignee: SHIMADZU CORPORATION
    Inventors: Hamish Ian Stewart, Matthew Gill, Roger Giles
  • Patent number: 10256088
    Abstract: An RF voltage is applied across each electrode of a first array of evenly spaced, parallel, and coplanar electrodes and its corresponding electrode of a second array of evenly spaced, parallel, and coplanar electrodes. The RF voltage varies in amplitude according to an RF voltage amplitude gradient. The RF voltage produces an array of different quadrupole RF electric fields in a uniform gap between the first array and the second array. A DC voltage is superimposed on each electrode of the first array and its corresponding electrode of the second array. The DC voltage varies according to a DC voltage gradient in order to produce a DC electric field in the uniform gap. When ions are introduced in the uniform gap, the DC electric field causes the ions to drift toward quadrupole RF electric fields with increasing RF voltage amplitudes where the ions are trapped according to their m/z.
    Type: Grant
    Filed: October 14, 2015
    Date of Patent: April 9, 2019
    Assignee: DH Technologies Development Pte. Ltd.
    Inventor: Takashi Baba
  • Patent number: 10222328
    Abstract: A method for detecting and counting particles suspended in fluids, such as bacteria suspended in urine, utilizing dynamic features of the suspended particles and employing light scattering measurements. The disclosed method is suitable for determining the susceptibility of bacteria to antibiotics. A cuvette for detecting bacteria in fluids, which is especially suited for the light scattering measurements, is provided.
    Type: Grant
    Filed: April 10, 2018
    Date of Patent: March 5, 2019
    Assignee: BacterioScan LTD.
    Inventor: Amnon Weichselbaum
  • Patent number: 10194698
    Abstract: An indirectly heated capillary aerosol generator comprises a capillary tube adapted to form an aerosol when liquid material in the capillary tube is heated to volatilize at least some of the liquid material therein and a thermally conductive material in thermal contact with the capillary tube. The indirectly heated capillary aerosol generator provides substantially even and uniform heating across the heated length of the capillary tube.
    Type: Grant
    Filed: March 31, 2017
    Date of Patent: February 5, 2019
    Assignee: Philip Morris USA Inc.
    Inventors: Marc D Belcastro, Jeffrey A Swepston
  • Patent number: 10161906
    Abstract: To widen the dynamic range of a dielectric barrier ionization detector (BID), an insertion length of a sample injection tube 16 into a second gas passage 11 is set so that a sample-gas ejection port 16a is located on the downstream side of a dilution gas from the upper edge of a collector electrode 14 at which a DC electric field concentrates. By this setting, although the detection sensitivity is lower than in the case where the sample-gas ejection port 16a is placed to maximize the detection sensitivity, the decrease in the detection sensitivity to high-concentration samples is reduced since absorption of light by the sample gas is alleviated. Consequently, the sample-concentration range with a linearly-changing sensitivity becomes wider than that of conventional BIDs. Although the detection sensitivity becomes lower than that of conventional BIDs, a detection sensitivity adequately higher than that of FIDs can be ensured.
    Type: Grant
    Filed: February 2, 2015
    Date of Patent: December 25, 2018
    Assignee: SHIMADZU CORPORATION
    Inventors: Kei Shinada, Shigeyoshi Horiike
  • Patent number: 10161904
    Abstract: A method for tracing a distribution of moving ions in an ion mobility spectrometer is provided, including steps: first selecting a sample having light-emitting characteristics as a tracing sample; subsequently, ionizing the tracing sample by using an ionization source, and feeding ions of the tracing sample to a drift tube of the ion mobility spectrometer; using a plate to collect the ions at a cross section to be detected; and finally processing the ions collected on the plate by using an appropriate means, thereby enabling the ions to emit light, and displaying a distribution view of movement positions of the ions on the cross section. By combining a light-emitting tracing means and movements of charged ions in an ion mobility spectrometer, it is able to master a position distribution of the charged ions in the ion mobility spectrometer more intuitively and practically.
    Type: Grant
    Filed: April 12, 2017
    Date of Patent: December 25, 2018
    Assignee: GRADUATE SCHOOL AT SHENZHEN, TSINGHUA UNIVERSITY
    Inventors: Kai Ni, Kaitai Guo, Quan Yu, Binchao Tang, Zhou Yu, Xiang Qian, Xiaohao Wang
  • Patent number: 10139369
    Abstract: A mass spectrometer device comprising an ion mobility separation device and a mass spectrometer that are coupled together. In order to achieve high efficiency, high throughput, and high sensitivity, the mass spectrometer is provided with: a first flow passageway 24 through which ions from an ion source 1 are introduced into the mass spectrometer 11 by passing through an ion mobility separation unit 2; a second flow passageway 21 through which the ions from the ion source are introduced into the mass spectrometer without passing through the ion mobility separation unit; and a switch means, such as shield units 4, 5, for switching between the first flow passageway 24 and the second flow passageway 21.
    Type: Grant
    Filed: December 24, 2014
    Date of Patent: November 27, 2018
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Hiroyuki Satake, Hideki Hasegawa, Masao Suga, Yuichiro Hashimoto
  • Patent number: 10101297
    Abstract: An analytical device for analyzing ions is provided comprising a separator for separating ions according to a physico-chemical property and an interface comprising one or more ion guides. A quadrupole rod set mass filter is arranged downstream of the interface. A control system is arranged and adapted: (i) to transmit a first group of ions which emerges from the separator through the interface with a first transit time t1; and (ii) to transmit a second group of ions which subsequently emerges from the separator through the interface with a second different transit time t2.
    Type: Grant
    Filed: December 19, 2016
    Date of Patent: October 16, 2018
    Assignee: MICROMASS UK LIMITED
    Inventors: Kevin Giles, Steven Derek Pringle, Jason Lee Wildgoose
  • Patent number: 10096458
    Abstract: A miniature mass spectrometer is disclosed comprising an atmospheric pressure ionization source, a first vacuum chamber having an atmospheric pressure sampling orifice or capillary, a second vacuum chamber located downstream of the first vacuum chamber and a third vacuum chamber located downstream of the second vacuum chamber. A first vacuum pump is arranged and adapted to pump the first vacuum chamber, wherein the first vacuum pump is arranged and adapted to maintain the first vacuum chamber at a pressure <10 mbar. A first RF ion guide is located within the first vacuum chamber and an ion detector is located in the third vacuum chamber. The ion path length from the atmospheric pressure sampling orifice or capillary to an ion detecting surface of the ion detector is ?400 mm.
    Type: Grant
    Filed: May 29, 2014
    Date of Patent: October 9, 2018
    Assignee: Micromass UK Limited
    Inventors: David Gordon, Daniel James Kenny
  • Patent number: 10026599
    Abstract: A method is disclosed comprising providing a biological sample on a swab, directing a spray of charged droplets onto a surface of the swab in order to generate a plurality of analyte ions, and analyzing the analyte ions.
    Type: Grant
    Filed: March 7, 2016
    Date of Patent: July 17, 2018
    Assignee: MICROMASS UK LIMITED
    Inventors: Zoltan Takats, Emrys Jones, James Ian Langridge, Michael Raymond Morris, Tamas Karancsi, Steven Derek Pringle, Julia Balog, Daniel Simon, Lajos Godorhazy, Daniel Szalay, Keith Richardson, Phillip Robert Bennett, David Alan MacIntyre, Pamela Pruski
  • Patent number: 10020179
    Abstract: A focusing ion guiding apparatus includes: at least one ion guiding inlet and ion guiding outlet connected to each other via a transport axial line; at least one group of focusing electrode structures comprising at least one smooth and non-concave focusing electrode or focusing electrode array to which a focusing voltage is applied, the focusing electrode structure causing the ions transported in the apparatus to be radially focused for many times under the action of a focusing electric field formed by the focusing electrode structure; and a neutral gas flow transported in the axial direction, a diffusion path of the gas flow in an at least partially radial direction relative to the axial direction being blocked by the focusing electrode or its bearing substrate to increase a transport velocity of the gas flow in the axial direction and reduce retention or turbulence of the transported ions.
    Type: Grant
    Filed: November 19, 2015
    Date of Patent: July 10, 2018
    Assignee: SHIMADZU CORPORATION
    Inventors: Gongyu Jiang, Jiaqi Shen, Wenjian Sun
  • Patent number: 10002750
    Abstract: Ion filter for FAIMS fabricated using the LIGA technique. The ion filter is manufactured using a metal layer to form the ion channels and an insulating support layer to hold the structure rigidly together after separation of the metal layer into two electrodes.
    Type: Grant
    Filed: May 11, 2016
    Date of Patent: June 19, 2018
    Assignee: Owlstone Medical Limited
    Inventors: Danielle Toutoungi, Matthew Hart, John Somerville, Jon Pearson, Max Allsworth, Richard Orrell, Antoni Negri, Jeremy Spinks, Martin Holden, Andrew H. Koehl, Alastair Taylor
  • Patent number: 9978575
    Abstract: Sample molecules are ionized producing a beam of ions using an ion source. A plurality of ion extractions are performed on the beam of ions using a TOF mass spectrometer. Electrical detections from each extraction are measured using an ADC, producing a mass sub-spectrum for each extraction. An ion m/z from the plurality of mass sub-spectra is selected. For each mass sub-spectrum, the amplitude and m/z of an ion within a m/z tolerance of the ion m/z is assigned to the corresponding amplitude band of a plurality of predetermined amplitude bands, producing a plurality of amplitude and m/z values for the each amplitude band. For each amplitude band of the plurality of predetermined amplitude bands, the plurality of amplitude and m/z values are combined into a peak, resulting in a plurality of peaks corresponding to the plurality of predetermined amplitude bands.
    Type: Grant
    Filed: September 21, 2015
    Date of Patent: May 22, 2018
    Assignee: DH Technologies Development Pte. Ltd.
    Inventor: Nic G. Bloomfield
  • Patent number: 9972482
    Abstract: A concentric APCI surface ionization probe, supersonic sampling tube, and method for use of the concentric APCI surface ionization probe and supersonic sampling tube are described. In an embodiment, the concentric APCI surface ionization probe includes an outer tube, an inner capillary, and a voltage source coupled to the outer tube and the inner capillary. The inner capillary is housed within and concentric with the outer tube such that ionized gas (e.g., air) travels out of the outer tube, reacts with a sample, and the resulting analyte ions are sucked into the inner capillary. A supersonic sampling tube can include a tube coupled to a mass spectrometer and/or concentric APCI surface ionization probe, where the tube includes at least one de Laval nozzle.
    Type: Grant
    Filed: June 27, 2017
    Date of Patent: May 15, 2018
    Assignee: Smiths Detection Montreal Inc.
    Inventors: Jan Hendrikse, Vladimir Romanov
  • Patent number: 9799499
    Abstract: In a mass spectrometric method of the invention, a mass spectrometer (2) is used having a mass separation unit (231, 234) before and after a collision cell (232) for fragmenting ions. When a product ion corresponding to a precursor ion set for a sample is selected by performing product ion scan with respect to the precursor ion, an exclusion range of mass-to-charge ratios is set based on information on non-selection ions input by a user, and a product ion that satisfies a predefined criterion is selected within a range of mass-to-charge ratios excluding the exclusion range in a product ion spectrum. According to the mass spectrometric method of the invention, product ions suited for measurement on a target compound can be selected.
    Type: Grant
    Filed: November 28, 2013
    Date of Patent: October 24, 2017
    Assignee: SHIMADZU CORPORATION
    Inventors: Yuko Kobayashi, Tairo Ogura
  • Patent number: 9786484
    Abstract: Implementations of methods and apparatuses are disclosed for decoding multiplexed information in a chromatographic system. Implementations may include the method of pulsing ions from an ion source through an analyzer according to a predetermined multiplexing scheme, each pulse including one or more ions corresponding to a sample, detecting a plurality of ion strikes at a detector, determining a data point for each ion strike, wherein each data point includes an intensity of a detected ion strike and a time of the detected ion strike, maintaining a multiplexed spectrum of the data points, the multiplexed spectrum including the data points, and demultiplexing the time shifted spectrum using the data points of the multiplexed spectrum.
    Type: Grant
    Filed: May 15, 2015
    Date of Patent: October 10, 2017
    Assignee: LECO Corporation
    Inventors: Peter Markel Willis, Jonathan Jaloszynski
  • Patent number: 9726621
    Abstract: In a helical resonator ion accelerator ions are injected into a hollow dielectric pipe forming a vacuum chamber along which the ions are accelerated. The dielectric pipe is wrapped with a coil and positioned inside a metal pipe. The dielectric pipe, the coil and the metal pipe are arranged coaxially on an axis along which ions are accelerated. A static or magnetic beam optic is used to radially focus the deuterium ions as they transit the accelerator. A pulse generator coupled to the coil is used to generate a voltage wave pulse. The pulse travels down the axis of the accelerator on the helix formed by the coil. An ion source injects deuterium ions along the dielectric pipe axis. A traveling voltage wave is accelerated by tapering the impedance of the accelerator along the accelerator to reduce the impedance per unit length of the accelerator.
    Type: Grant
    Filed: October 12, 2015
    Date of Patent: August 8, 2017
    Assignee: HELIONX LLC
    Inventor: Dennis E. Bahr
  • Patent number: 9698002
    Abstract: A method of mass analysis and a mass spectrometer are provided wherein a batch of ions is accumulated in a mass analyzer; the batch of ions accumulated in the mass analyzer is detected using image current detection to provide a detected signal; the number of ions in the batch of ions accumulated in the mass analyzer is controlled using an algorithm based on a previous detected signal obtained using image current detection from a previous batch of ions accumulated in the mass analyzer; wherein one or more parameters of the algorithm are adjusted based on a measurement of ion current or charge obtained using an independent detector located outside of the mass analyzer.
    Type: Grant
    Filed: April 18, 2016
    Date of Patent: July 4, 2017
    Assignee: Thermo Fisher Scientific (Bremen) GmbH
    Inventors: Jan-Peter Hauschild, Oliver Lange, Ulf Fröhlich, Andreas Wieghaus, Alexander Kholomeev, Alexander Makarov
  • Patent number: 9673033
    Abstract: A multi-reflection mass spectrometer comprising two ion-optical mirrors, each mirror elongated generally along a drift direction (Y), each mirror opposing the other in an X direction and having a space therebetween, the X direction being orthogonal to Y; the mass spectrometer further comprising one or more compensation electrodes each electrode being located in or adjacent the space extending between the opposing mirrors; the compensation electrodes being configured and electrically biased in use so as to produce, in at least a portion of the space extending between the mirrors, an electrical potential offset which: (i) varies as a function of the distance along the drift length, and/or; (ii) has a different extent in the X direction as a function of the distance along the drift length. In a preferred embodiment the period of ion oscillation between the mirrors is not substantially constant along the whole of the drift length.
    Type: Grant
    Filed: September 14, 2015
    Date of Patent: June 6, 2017
    Assignee: Thermo Fisher Scientific (Bremen) GmbH
    Inventors: Dmitry Grinfeld, Alexander Makarov
  • Patent number: 9659761
    Abstract: A method and apparatus of compensating a magnetic field inhomogeneity in a dynamically harmonized FT-ICR cell is presented, based on adding of extra electrodes into the cell, the extra electrodes being shaped in such a way that the averaged electric field created by these electrodes produces a counter force to the forces caused by the inhomogeneous magnetic field on the cycling ions.
    Type: Grant
    Filed: September 11, 2013
    Date of Patent: May 23, 2017
    Assignee: Bruker Daltonik GmbH
    Inventors: Yury Kostyukevich, Evgeny Nikolaev, Gleb Vladimirov
  • Patent number: 9587292
    Abstract: A method of isolating 99Mo produced using a (n,?) reaction according to example embodiments may include vaporizing a source compound containing 98Mo and 99Mo. The vaporized source compound may be ionized to form ions containing 98Mo and 99Mo. The ions may be separated to isolate the ions containing 99Mo. The isolated ions containing 99Mo may be collected with a collector. Accordingly, the isolated 99Mo may have a relatively high specific radioactivity and, in turn, may be used to produce the diagnostic radioisotope, 99mTc, through radioactive decay.
    Type: Grant
    Filed: October 1, 2009
    Date of Patent: March 7, 2017
    Assignee: Advanced Applied Physics Solutions, Inc.
    Inventors: Suzanne Lapi, Thomas J. Ruth, Dirk W. Becker, John M. D'Auria
  • Patent number: 9583360
    Abstract: In one embodiment, a substrate processing apparatus, includes: a chamber; a first electrode disposed in the chamber; a second electrode disposed in the chamber to face the first electrode, and to hold a substrate; an RF power supply to apply an RF voltage with a frequency of 50 MHz or more to the second electrode; and a pulse power supply to repeatedly apply a voltage waveform including a negative voltage pulse and a positive voltage pulse of which delay time from the negative voltage pulse is 50 nano-seconds or less to the second electrode while superposing on the RF voltage.
    Type: Grant
    Filed: March 20, 2012
    Date of Patent: February 28, 2017
    Assignee: Kabushiki Kaisha Toshiba
    Inventors: Akio Ui, Hisataka Hayashi, Keisuke Kikutani
  • Patent number: 9576783
    Abstract: The invention relates to embodiments of high-resolution time-of-flight (TOF) mass spectrometers with special reflectors. The invention provides reflectors with ideal energy and solid angle focusing, based on Cassini ion traps, and proposes that a section of the flight path of the TOF mass spectrometers takes the form of a Cassini reflector. It is particularly favorable to make the ions fly through this Cassini reflector in a TOF mass spectrometer at relatively low energies, with kinetic energies of below one or two kiloelectronvolts. This results in a long, mass-dispersive passage time in addition to the time of flight of the other flight paths, without increasing the energy spread, angular spread or temporal distribution width of ions of the same mass. It is also possible to place several Cassini reflectors in series in order to extend the mass-dispersive time of flight. Several TOF mass spectrometers for axial as well as orthogonal ion injection with Cassini reflectors are presented.
    Type: Grant
    Filed: July 8, 2014
    Date of Patent: February 21, 2017
    Inventor: Claus Köster
  • Patent number: 9536722
    Abstract: An ion guide for mass spectrometry comprising an electrode arrangement of at least two electrodes, at least one of which is an RF electrode, arranged adjacent to each other but spaced apart on a planar surface of a dielectric material and arranged at a distance from an ion flow path, wherein a portion of the dielectric surface is exposed between an adjacent pair of the spaced apart electrodes and wherein at least one electrode of said adjacent pair of electrodes is arranged to overhang the exposed portion of surface between them such that there is no direct line of sight from the ion flow path to the exposed portion of dielectric surface. The device enables RF guiding of ions accompanied by much reduced charging-up of dielectric surfaces and reduced amount of collisions of neutral species with electrodes.
    Type: Grant
    Filed: September 19, 2013
    Date of Patent: January 3, 2017
    Assignee: Thermo Fisher Scientific (Bremen) GmbH
    Inventors: Dmitry Grinfeld, Jan-Peter Hauschild, Wilko Balschun, Eduard Denisov, Alexander Makarov
  • Patent number: 9536723
    Abstract: A field terminator includes a plurality of electrode plates positioned around a guide axis at a radial distance therefrom. The plates generate a quadrupole DC field such that a polarity on each plate is opposite to a polarity on the plates adjacent thereto. The plates may be positioned at an axial end of a quadrupole ion guide such as a mass filter. In addition to an RF field, the ion guide may generate a quadrupole DC field. The DC field of the plates may be opposite in polarity to that of the ion guide.
    Type: Grant
    Filed: February 6, 2015
    Date of Patent: January 3, 2017
    Assignee: Agilent Technologies, Inc.
    Inventors: James L. Bertsch, Kenneth R. Newton
  • Patent number: 9523657
    Abstract: This invention describes an ion mobility spectrometer and operational methods for chemical analysis. The ion mobility spectrometer allows for continuous operation and rapid temperature control to reach designed operational conditions, as well as analysis under a temperature gradient.
    Type: Grant
    Filed: September 2, 2012
    Date of Patent: December 20, 2016
    Assignee: Excellims Corporation
    Inventor: Ching Wu
  • Patent number: 9514921
    Abstract: Systems and methods are provided for correcting uniform detector saturation. In one method, a mass analyzer analyzes N extractions of an ion beam. A nonzero amplitude from an ADC detector subsystem is counted as one ion, producing a count of one for each ion of each sub-spectrum. The ADC amplitudes and counts of the N sub-spectra are summed, producing a spectrum that includes a summed ADC amplitude and a total count for each ion of the spectrum. A probability that the total count arises from single ions hitting the detector is calculated. For each ion of the spectrum where the probability exceeds a threshold value, an amplitude response is calculated, producing amplitude responses for ions found to be single ions hitting the detector. Amplitude responses are combined, producing a combined amplitude response. The total count is dynamically corrected using the combined amplitude response and the summed ADC amplitude.
    Type: Grant
    Filed: August 7, 2014
    Date of Patent: December 6, 2016
    Assignee: DH Technologies Development Pte. Ltd.
    Inventors: Nic G. Bloomfield, Alexandre V. Loboda
  • Patent number: 9508534
    Abstract: Method for operating a mass spectrometer includes supplying a quantity of ions to an ion detector. The ion detector can include a conversion dynode operating in a first polarity and an electron multiplier. The method further includes adjusting the gain of the electron multiplier to determine a first set of calibration parameters, and calculating a second set of calibration parameters for the electron multiplier from the first set of calibration parameters. The second set of calibration parameters are for a second polarity of the conversion dynode. The method can further include configuring the ion detector to operate at the second polarity based on the second set of calibration parameters, and supplying ions of the second polarity to the mass spectrometer, and detecting an ion at a particular mass to charge ratio using the ion detector.
    Type: Grant
    Filed: November 7, 2014
    Date of Patent: November 29, 2016
    Assignee: Thermo Finnigan LLC
    Inventors: Oleg Silivra, Harald Oser, Joshua T. Maze
  • Patent number: 9484192
    Abstract: A method of ion imaging is disclosed comprising scanning a sample and acquiring first mass spectral data related to a first pixel location at a first spatial resolution and determining whether or not the first mass spectral data satisfies a condition. If it is determined that the first mass spectral data does satisfy the condition then the first mass spectral data is stored, recorded or prioritized. If it is determined that the first mass spectral data does not satisfy the condition then the first mass spectral data is discarded or downgraded. Scanning of the sample then continues at the first spatial resolution and further mass spectral data related to further pixel locations is acquired.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: November 1, 2016
    Assignee: Micromass UK Limited
    Inventors: Richard Chapman, Jeffery Mark Brown, Paul Murray, Keith Richardson, Emmy Maria Hoyes
  • Patent number: 9373489
    Abstract: An ion guiding device is disclosed comprising a first ion guide which is conjoined with a second ion guide. Ions are urged across a radial pseudo-potential barrier which separates the two guiding regions by a DC potential gradient. Ions may be transferred from an ion guide which has a relatively large cross-sectional profile to an ion guide which has a relatively small cross-sectional profile in order to improve the subsequent ion confinement of the ions.
    Type: Grant
    Filed: May 4, 2015
    Date of Patent: June 21, 2016
    Assignee: Micromass UK Limited
    Inventor: Kevin Giles
  • Patent number: 9355809
    Abstract: According to one embodiments, an ion source connected with a vacuum-exhausted downstream apparatus is provided. The ion source includes a vacuum chamber which is vacuum-exhausted, a target which is set in the vacuum chamber and generates ions by irradiation of a laser beam, a transportation unit which transports the ions generated by the target to the downstream apparatus, and a vacuum sealing unit which seals the transportation unit so as to separate vacuum-conditions of the vacuum chamber side and the downstream apparatus side before exchanging the target set in the vacuum chamber.
    Type: Grant
    Filed: February 26, 2013
    Date of Patent: May 31, 2016
    Assignee: KABUSHIKI KAISHA TOSHIBA
    Inventors: Akiko Kakutani, Kiyoshi Hashimoto, Kiyokazu Sato, Akihiro Osanai, Takeshi Yoshiyuki, Tsutomu Kurusu, Kazuo Hayashi
  • Patent number: 9330886
    Abstract: To control of an irradiation installation, a particle beam is generated with a beam intensity, and a beam quality of the particle beam is monitored with a beam monitoring device. One of several adjustable measurement ranges is selected, wherein the measurement range of the beam monitoring device is set depending on the beam intensity of the particle beam and/or depending on a particle count to be applied.
    Type: Grant
    Filed: April 20, 2012
    Date of Patent: May 3, 2016
    Assignee: GSI Helmholtzzentrum fur Schwerionenforschung GmbH
    Inventors: Christoph Bert, Eike Rietzel
  • Patent number: 9324548
    Abstract: A method and a device increases (e.g., uniformly) the internal energy of ions, in order to remove water shells or adducts, to decompose clusters or molecular agglomerations, to unfold large folded ions, or to prepare ions for fragmentation with high yield. The ions can be heated at a gas pressure of a few hectopascal viscously dragged through a tube comprising on-axis RF fields with strong axial field components. The ions are introduced, as usual together with entraining gas, into a vacuum system of a mass spectrometer through a small hole or capillary, and are driven by the gas flow through the tube with the RF fields. The RF fields decelerate and re-accelerate the ions, which travel through the tube, in rapid succession mainly in forward and backward direction, thus causing high numbers of collisions with the gas molecules and heating up the ions in a uniform manner.
    Type: Grant
    Filed: May 8, 2014
    Date of Patent: April 26, 2016
    Assignee: Bruker Daltonik GmbH
    Inventors: Thorsten Benter, Sonja Klee
  • Patent number: 9293310
    Abstract: An ionization chamber with spatial distribution electrode for monitor hadron beam currents used for therapeutic treatment. Ionization chamber comprises humidity control, environmental sensing and real-time correction thereof. A flexible hermetic seal provide for ambient pressure equalization. X-Y electrode planes measure Gaussian distribution of incident particle beam. Methods described herein are suitable to fabricate highly accurate, low scattering electrodes with high spatial resolutions.
    Type: Grant
    Filed: March 17, 2014
    Date of Patent: March 22, 2016
    Assignee: Pyramid Technical Consultants, Inc.
    Inventors: R. Paul Boisseau, Andrew Dart, John S Gordon, William P Nett
  • Patent number: 9257269
    Abstract: This invention describes an apparatus and method with a combined primary electrospray and secondary electrospray ionization source used to enhance ionization efficiency. The solid phase as well as liquid phase sampling, ionization, and detection is described.
    Type: Grant
    Filed: October 15, 2012
    Date of Patent: February 9, 2016
    Assignee: Excellims Corporation
    Inventor: Ching Wu
  • Patent number: 9245723
    Abstract: A method of operating a gas-filled collision cell in a mass spectrometer is provided. The collision cell has a longitudinal axis. Ions are caused to enter the collision cell. A trapping field is generated within the collision cell so as to trap the ions within a trapping volume of the collision cell, the trapping volume being defined by the trapping field and extending along the longitudinal axis. Trapped ions are processed in the collision cell and a DC potential gradient is provided, using an electrode arrangement, resulting in a non-zero electric field at all points along the axial length of the trapping volume so as to cause processed ions to exit the collision cell. The electric field along the axial length of the trapping volume has a standard deviation that is no greater than its mean value.
    Type: Grant
    Filed: August 24, 2015
    Date of Patent: January 26, 2016
    Assignee: Thermo Fisher Scientific (Bremen) GmbH
    Inventors: Alexander Makarov, Eduard V. Denisov, Wilko Balschun, Dirk Nolting, Jens Griep-Raming
  • Patent number: 9200962
    Abstract: A method includes determining a highest peak of an optical spectrum waveform contained within a wavelength window having a fixed wavelength range, the wavelength window having a beginning wavelength value and an ending wavelength value, and iteratively modifying the beginning and ending wavelength values, within the fixed wavelength range, to shift the wavelength window so the highest peak is centered at a first position within the wavelength window. The method may further include determining a second highest peak of the optical spectrum waveform and iteratively expanding or contracting the optical spectrum waveform, while maintaining the highest peak centered at the first position, to locate the second highest peak at a predetermined position within the wavelength window. The method may be used for window calibration to enable repeatable and precise harmonic analysis of optical spectra, such as Raman spectra.
    Type: Grant
    Filed: June 21, 2012
    Date of Patent: December 1, 2015
    Assignee: THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY
    Inventors: Timothy J. Russin, Alicia M Russin
  • Patent number: 9188570
    Abstract: A detector for gas chromatography using two or more ionization sources within a single body to separately provide ionization energy to a column gas eluent to provide electrical discharge to two or more collecting electrodes provides improved selectivity and may be so used. Use is made of combined bias/collecting electrodes or of sets of separated bias and collecting electrodes. The use of multiple ionization sources permits generation of multiple detector outputs from within a common body and of a common constituent flow. The ionization sources and any applicable discharge gas and dopant may be selected based on desired selectivity.
    Type: Grant
    Filed: August 6, 2014
    Date of Patent: November 17, 2015
    Assignee: Valco Instruments Company, L.P.
    Inventors: Stanley D. Stearns, Huamin Cai
  • Patent number: 9159539
    Abstract: A system and method for acquisition of mass spectrometry data is configured to provide a stream of charged particles (e.g., from an analytical volume). A primary mass spectrometer (e.g., time-of-flight mass spectrometer) may be used to separate charged particles of the stream of charged particles based on their mass-to-charge ratio and detect the charged particles in a mass-to-charge spectrum. A stream of precursor ions having a selected mass range may be diverted from the stream of charged particles for fragmentation to provide fragment ions (e.g., fragment ions from the analytical volume). The fragment ions may be provided to a second mass spectrometer for analysis of the fragment ions (e.g., during the same time as the time-of-flight mass spectrometer is separating and detecting charged particles of the stream of charged particles based on their mass-to-charge ratio).
    Type: Grant
    Filed: March 13, 2013
    Date of Patent: October 13, 2015
    Assignees: ULVAC-PHI, INCORPORATED
    Inventors: Paul E. Larson, John S. Hammond, Gregory L. Fisher, Ron M. Heeren
  • Patent number: 9147563
    Abstract: A method and apparatus for tandem mass spectrometry is disclosed. Precursor ions are fragmented and the fragments are accumulated in parallel, by converting an incoming stream of ions from an ion source (10) into a time separated sequence of multiple precursor ions which are then assigned to their own particular channel of a multi compartment collision cell (40). In this manner, precursor ion species, being allocated to their own dedicated fragmentation cell chambers (41, 42 . . . 43) within the fragmentation cell (40), can then be captured and fragmented by that dedicated fragmentation chamber at optimum energy and/or fragmentation conditions.
    Type: Grant
    Filed: December 20, 2012
    Date of Patent: September 29, 2015
    Assignee: Thermo Fisher Scientific (Bremen) GmbH
    Inventor: Alexander Alekseevich Makarov
  • Patent number: 9082597
    Abstract: A data acquisition system and method are described that may be used with various spectrometers. The data acquisition system may include an ion detector, an initial processing module, and a spectra processing module. The initial processing module is provided for processing the ion detection signals and for supplying processed signals to the spectra processing module. The spectra processing module generates spectra from the processed signals and supplies the generated spectra to an external processor for post-processing. The spectra processing module may include an ion statistics filter and/or a peak histogram filtering circuit.
    Type: Grant
    Filed: August 5, 2011
    Date of Patent: July 14, 2015
    Assignee: LECO Corporation
    Inventors: Peter M. Willis, Michael C. Mason, Mark R. Wheeler, Viatcheslav B. Artaev, Julie R. Pitz
  • Patent number: 9040907
    Abstract: An apparatus includes an electrostatic ion trap and electronics configured to measure parameters of the ion trap and configured to adjust ion trap settings based on the measured parameters. A method of tuning the electrostatic ion trap includes, under automatic electronic control, measuring parameters of the ion trap and adjusting ion trap settings based on the measured parameters.
    Type: Grant
    Filed: October 30, 2012
    Date of Patent: May 26, 2015
    Assignee: MKS Instruments, Inc.
    Inventors: Gerardo A. Brucker, G. Jeffery Rathbone, Brian J. Horvath, Timothy C. Swinney, Stephen C. Blouch, Jeffrey G. McCarthy, Timothy R. Piwonka-Corle
  • Patent number: RE45553
    Abstract: A mass filter apparatus for filtering a beam of ions is described. The apparatus comprises an ion beam source and first and second mass filter stages in series to receive the ion beam. A vacuum system maintains the first and second filter stages at substantially the same operating pressure, below 10?3 torr. The first mass filter stage transmits only ions having a sub-range of mass-to-charge ratios including a selected mass-to-charge ratio. The second filter transmits only ions of the selected mass-to-charge ratio. The second mass filter can achieve high accuracy detection without being subjected to problems such as build-up of material on quadrupole rods, resulting in a distorted electric field close to the rods. The first mass filter acts as a coarse filter, typically transmitting 1% of ions received from the ion source. Thus, the detection accuracy and lifetime of mass spectrometers embodying this invention are greatly improved. A mass filter apparatus for filtering a beam of ions is described.
    Type: Grant
    Filed: September 19, 2013
    Date of Patent: June 9, 2015
    Assignee: Thermo Fisher Scientific Inc.
    Inventor: Philip Marriott