Ionic Separation Or Analysis Patents (Class 250/281)
  • Patent number: 11158496
    Abstract: A miniature electrode apparatus is disclosed for trapping charged particles, the apparatus including, along a longitudinal direction: a first end cap electrode; a central electrode having an aperture; and a second end cap electrode. The aperture is elongated in the lateral plane and extends through the central electrode along the longitudinal direction and the central electrode surrounds the aperture in a lateral plane perpendicular to the longitudinal direction to define a transverse cavity for trapping charged particles.
    Type: Grant
    Filed: November 26, 2018
    Date of Patent: October 26, 2021
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: J. Michael Ramsey, Kevin Schultze
  • Patent number: 11158495
    Abstract: A multi-reflecting time-of-flight mass spectrometer (MR-TOF MS) includes an ion source, an orthogonal accelerator, and an ion mirror assembly. The ion source is capable of generating a beam of ions, and is arranged to accelerate the ions in a first direction along a first axis. The orthogonal accelerator is arranged to accelerate the ions in a second direction along a second axis. The second direction is orthogonal to the first direction. The ion mirror assembly includes a plurality of gridless planar mirrors and a plurality of electrodes. The plurality of electrodes are arranged to provide time-focusing of ions along a third axis substantially independent of ion energy and ion position.
    Type: Grant
    Filed: March 26, 2018
    Date of Patent: October 26, 2021
    Assignee: LECO Corporation
    Inventors: Viatcheslav Artaev, Anatoly N. Verenchikov
  • Patent number: 11150249
    Abstract: A microorganism identification method utilizing mass spectrometry is provided. More specifically, a method for identifying a phylotype of Cutibacterium acnes utilizing mass spectrometry is provided. The method includes a) a step for reading out a m/z value of a peak derived from a marker protein on a mass spectrum which is obtained by mass spectrometry of a sample containing microorganisms; and b) a step for judging whether the sample contains Cutibacterium acnes (C. acnes) based on the m/z value.
    Type: Grant
    Filed: February 26, 2020
    Date of Patent: October 19, 2021
    Assignee: SHIMADZU CORPORATION
    Inventor: Kanae Teramoto
  • Patent number: 11152201
    Abstract: For an automatic adjustment of a detector voltage, a measurement of a standard sample is performed, in which a reflection voltage generator under the control of an autotuning controller applies, to a reflector, voltages which are different from those applied in a normal measurement and do not cause temporal conversion of ions. Ions having the same m/z simultaneously ejected from an ejector are dispersed in the temporal direction and reach a detector. Therefore, a plurality of low peaks corresponding to individual ions are observed on a profile spectrum. A peak-value data acquirer determines a wave-height value of each peak. A wave-height-value list creator creates a list of wave-height values. A detector voltage determiner searches for a detector voltage at which the median of the wave-height values in the wave-height-value list falls within a reference range.
    Type: Grant
    Filed: April 26, 2018
    Date of Patent: October 19, 2021
    Assignee: SHIMADZU CORPORATION
    Inventors: Tomoyuki Oshiro, Daisuke Okumura, Yuta Miyazaki, Hiroaki Kozawa
  • Patent number: 11145500
    Abstract: In one aspect, a time-of-flight mass spectrometer includes a source comprising a backing plate configured to operably couple to a core sample containing component, and an acceleration region. The time-of-flight mass spectrometer also includes a time-of-flight mass analyzer operably associated with the source region. In some embodiments, the core sample core sample containing component is a coring drill bit. In some embodiments, core containing component is configured to couple to the backing plate of the source region from the opposite side of the acceleration region. In some embodiments, core containing component is configured to couple to the backing plate of the source region on the acceleration region side of the backing plate. In some embodiments, the acceleration region is a single-stage acceleration region. In other embodiments, the acceleration region is a two-stage acceleration region.
    Type: Grant
    Filed: March 4, 2019
    Date of Patent: October 12, 2021
    Inventors: Timothy Cornish, Scott Ecelberger
  • Patent number: 11145501
    Abstract: Thermal management arrangements for analysis systems including a plasma source such as inductively-coupled-plasma are disclosed. An analysis system may include a plasma source configured to a plasma source configured to receive and ionize a sample to create an ionized sample, and an instrument such as a mass spectrometer or optical emission spectrometer configured to receive and analyze the ionized sample. A heat shield may be positioned between the plasma source and the instrument, and the heat shield may be constructed and arranged to direct heated gas and/or plasma from the plasma source away from the instrument. In some instances, the heated gas and/or plasma may be extracted from a chamber containing the plasma source.
    Type: Grant
    Filed: February 20, 2020
    Date of Patent: October 12, 2021
    Assignee: PerkinElmer, Inc.
    Inventors: Tak Shun Cheung, Chui Ha Cindy Wong, Andrew Icasiano, Brian Chan
  • Patent number: 11139155
    Abstract: A laser desorption/ionization method, includes: a first step of preparing a sample support body including a substrate on which a plurality of through holes opening to a first surface and a second surface facing each other are formed, and a conductive layer provided on at least the first surface; a second step of introducing a sample and a solvent having refractoriness in a vacuum into the plurality of through holes; and a third step of ionizing a component of the sample by irradiating the first surface with laser beam while applying a voltage to the conductive layer.
    Type: Grant
    Filed: October 5, 2018
    Date of Patent: October 5, 2021
    Assignee: HAMAMATSU PHOTONICS K.K.
    Inventors: Yasuhide Naito, Takayuki Ohmura, Masahiro Kotani
  • Patent number: 11137380
    Abstract: A method of analyzing a complex sample includes performing a sequential chromatographic-IMS-MS analysis of a sample to obtain a plurality of experimental mass spectra having isotopic clusters, wherein each spectrum of the plurality of spectra is associated with a chromatographic retention time and an ion-mobility drift time. The method also includes calculating a model isotopic cluster of a precursor or product ion associated with a candidate compound in the sample, in correspondence to the natural isotopic-abundance ratios of elements composing the compound. The method further includes comparing peaks of the model isotopic cluster to corresponding peaks of an isotopic cluster of one of the experimental mass spectra to extract one or more saturated or interfered peaks of the experimental isotopic cluster, wherein at least one of the peaks of the experimental isotopic cluster is un-saturated and un-interfered.
    Type: Grant
    Filed: May 19, 2020
    Date of Patent: October 5, 2021
    Assignee: Waters Technologies Corporation
    Inventors: Scott J. Geromanos, Marc V. Gorenstein, Daniel Golick, Steven J. Ciavarini
  • Patent number: 11133162
    Abstract: A sample introduction system for a spectrometer comprises a desolvation region that receives or generates sample ions from a solvent matrix and removes at least some of the solvent matrix from the sample ions. A separation chamber downstream of the desolvation region has a separation chamber inlet communicating with the desolvation region, for receiving the desolvated sample ions along with non-ionised solvent and solvent ion vapours. The separation chamber has electrodes for generating an electric field within the separation chamber, defining a first flow path for sample ions between the separation chamber inlet and a separation chamber outlet. Unwanted solvent ions and non-ionised solvent vapours are directed away from the separation chamber outlet. The sample introduction system has a reaction chamber with an inlet communicating with the separation chamber outlet, for receiving the sample ions from the separation chamber and for decomposing the received ions into smaller products.
    Type: Grant
    Filed: July 1, 2020
    Date of Patent: September 28, 2021
    Assignee: Thermo Fisher Scientific (Bremen) GmbH
    Inventors: Alexander A. Makarov, Stevan R. Horning
  • Patent number: 11133167
    Abstract: In one aspect, a curtain and orifice plate assembly for use in a mass spectrometry system is disclosed, which comprises a curtain plate including a first printed circuit board (PCB) having an aperture configured for receiving ions generated by an ion source of the mass spectrometry system and at least one gas-flow channel, where said first PCB has at least one metal coating disposed on at least a portion thereof. The assembly further includes an orifice plate coupled to the curtain plate, which includes a PCB providing an orifice that is substantially aligned with the aperture of the curtain plate so that the ions entering the assembly via said aperture of the curtain plate can exit the assembly via said orifice of the orifice plate, where the second PCB has at least one metal coating disposed on at least a portion thereof.
    Type: Grant
    Filed: March 1, 2019
    Date of Patent: September 28, 2021
    Assignee: DH Technologies Development Pte. Ltd.
    Inventor: Robert Haufler
  • Patent number: 11133164
    Abstract: A method of analysis is disclosed comprising providing a sample on an insulating substrate such as a petri dish 4 and contacting e.g. the rear surface of the insulating substrate with a first electrode 9. The method further comprises contacting the sample with a second electrode 2 and applying an AC or RF voltage to the first and second electrodes 9,2 in order to generate an aerosol from the sample.
    Type: Grant
    Filed: January 31, 2020
    Date of Patent: September 28, 2021
    Assignee: Micromass UK Limited
    Inventors: Steven Derek Pringle, Lajos Godorhazy, Daniel Simon, Daniel Szalay, Zoltan Takats, Tamas Karancsi
  • Patent number: 11127580
    Abstract: A detector system for targeted analysis and/or sample collection by distance-of-flight mass spectrometry (tDOF-MS).
    Type: Grant
    Filed: November 16, 2018
    Date of Patent: September 21, 2021
    Assignee: UNM Rainforest Innovations
    Inventor: Christie Enke
  • Patent number: 11127581
    Abstract: The invention generally relates to logical operations in mass spectrometry. The system comprising a mass spectrometer comprising one or more ion traps; and a central processing unit (CPU), and storage coupled to the CPU for storing instructions that when executed by the CPU cause the system to apply one or more scan functions to the one or more ion traps, the scan functions being combine together.
    Type: Grant
    Filed: March 18, 2019
    Date of Patent: September 21, 2021
    Assignee: Purdue Research Foundation
    Inventors: Robert Graham Cooks, Dalton Snyder, Lucas Szalwinski
  • Patent number: 11120983
    Abstract: A miniature, low cost mass spectrometer capable of unit resolution over a mass range of 10 to 50 AMU. The mass spectrometer incorporates several features that enhance the performance of the design over comparable instruments. An efficient ion source enables relatively low power consumption without sacrificing measurement resolution. Variable geometry mechanical filters allow for variable resolution. An onboard ion pump removes the need for an external pumping source. A magnet and magnetic yoke produce magnetic field regions with different flux densities to run the ion pump and a magnetic sector mass analyzer. An onboard digital controller and power conversion circuit inside the vacuum chamber allows a large degree of flexibility over the operation of the mass spectrometer while eliminating the need for high-voltage electrical feedthroughs. The miniature mass spectrometer senses fractions of a percentage of inlet gas and returns mass spectra data to a computer.
    Type: Grant
    Filed: May 18, 2020
    Date of Patent: September 14, 2021
    Assignee: Massachusetts Institute of Technology
    Inventors: Ian W. Hunter, Brian D. Hemond, Harold F. Hemond
  • Patent number: 11120984
    Abstract: The invention generally relates to ion traps and methods of use thereof. In certain embodiments, the invention provides a system that includes a mass spectrometer including an ion trap, and a central processing unit (CPU). The CPU has storage that is coupled to the CPU for storing instructions that when executed by the CPU cause the system to apply a constant radio frequency (RF) signal to the ion trap, and apply a first alternating current (AC) signal to the ion trap the frequency of which varies as a function of time.
    Type: Grant
    Filed: October 21, 2016
    Date of Patent: September 14, 2021
    Assignee: Purdue Research Foundation
    Inventors: Robert Graham Cooks, Jason Duncan, Joshua Wiley
  • Patent number: 11113362
    Abstract: A method of estimating a parameter for fitting a multi-component Taylorgram model to Taylorgram data g(t) is disclosed. The data comprises a multi-component Taylorgram peak or front at t=tr. The method comprises: evaluating a value of an integration or differential of the data; determining the parameter, based on an analytical expression that includes the value of the integral or differential of the data, the parameter corresponding with a physical property of a sample from which the Taylorgram data was obtained.
    Type: Grant
    Filed: March 24, 2016
    Date of Patent: September 7, 2021
    Assignee: Malvern Panalytical Limited
    Inventors: Seyi Latunde-Dada, Oksana Iryna Leszczyszyn, Karl Hampton, Rachel Bott
  • Patent number: 11107668
    Abstract: Four rod electrodes (50a to 50d) for separating ions according to a mass-to-charge ratio are held by a rod holder (51). The rod holder (51) is placed on a metal holder sustaining stand (52) provided on a bottom surface of a vacuum housing (1), and is fixed while being pressed by a fixation band (53) fixed to the holder sustaining stand (52) with screws (56). A heat release layer (55) made from heat dissipation silicone or the like is inserted between the fixation band (53) and the rod holder (51) and between the fixation band (53) and the holder sustaining stand (52). Therefore, heat generated in the rod holder (51) due to dielectric loss is not only directly transmitted to the holder sustaining stand (52), but also efficiently transmitted to the holder sustaining stand (52) through the fixation band (53).
    Type: Grant
    Filed: February 7, 2018
    Date of Patent: August 31, 2021
    Assignee: SHIMADZU CORPORATION
    Inventors: Manabu Ueda, Kota Nagasao
  • Patent number: 11099242
    Abstract: The present invention relates to a device (1) for measuring a magnetic field (B) and/or an electric field (E) comprising:—a measurement cell (3) enclosing a gas that is sensitive to the Zeeman effect and/or to the Stark effect, a polarised light source (7) the wavelength of which is tuned to an absorption line of the gas that is sensitive to the Zeeman effect and/or to the Stark effect,—at least one polarimetry system (11) configured to measure a first parameter corresponding to the rotation by a polarisation angle caused by the passage of the beam (9) through the measurement cell (3) enclosing a gas that is sensitive to the Zeeman effect and/or to the Stark effect,—a system (13) for measuring absorption, configured to measure a second parameter corresponding to the absorption of the beam (9) by the gas that is sensitive to the Zeeman effect and/or to the Stark effect in the measurement cell (3), and a processing unit (15) configured to combine the measurement of the first parameter corresponding to the rotat
    Type: Grant
    Filed: December 18, 2018
    Date of Patent: August 24, 2021
    Assignee: Supergrid Institute
    Inventors: Geoffrey Renon, Paul Vinson
  • Patent number: 11099161
    Abstract: An ionizer includes an ionization probe (21) provided with a capillary (211), a metallic slender tube (212), and a nebulizing gas pipe (213). The ionization probe (21) is equipped to perform ESI-based ionization of components in a liquid sample. An electroconductive capillary (22) is disposed at a position forward in a flow direction of a nebulized flow of the liquid sample from the ionization probe (21). A high voltage from a high voltage power supply (23) is applied to the electroconductive capillary (22) to induce corona discharge so that the components in the liquid sample are ionized by the APCI as well. At the time of tuning the ionizer, a standard sample solution is provided through the electroconductive capillary (22), and a high voltage from the high voltage power supply (23) is applied to the electroconductive capillary (22) so that components in the standard sample solution are ionized by the ESI or due to an ion molecular reaction with solvent molecular ions produced in the ionization probe (21).
    Type: Grant
    Filed: November 29, 2016
    Date of Patent: August 24, 2021
    Assignee: SHIMADZU CORPORATION
    Inventor: Manabu Ueda
  • Patent number: 11092568
    Abstract: A method of manufacture for a ion mobility filter is disclosed. The method of manufacturing an ion filter for a spectrometry system includes providing a sheet of conductive material and defining a plurality of ion filters on the sheet. The definition of the plurality of ion filters is achieved by forming an electrode layer for each ion filter on the sheet, where each electrode layer comprises at least one ion channel and an isolation channel surrounding the at least one ion channel. A support layer on each electrode layer is also formed. Each support layer comprises an aperture at least partially aligned with the at least one ion channel. The ion filter is then separated. The risk of contaminants entering the at least one ion channel when separating the ion filters is reduced by surrounding the at least one ion channel with the isolation channel.
    Type: Grant
    Filed: November 15, 2018
    Date of Patent: August 17, 2021
    Assignees: Owlstone Medical Limited, Owlstone Inc.
    Inventors: Max Allsworth, Daniel Melhirst, Matthew Hart
  • Patent number: 11087964
    Abstract: A method for cleaning an electrospray emitter of a mass spectrometer, comprises: (a) changing a mode of operation of the electrospray emitter from a stable jet mode of operation to a dripping mode or a pulsating mode of operation by lowering a magnitude of a voltage applied between an counter electrode and the electrospray emitter; (b) causing a cleaning solvent to flow through the electrospray emitter at least until a droplet of the cleaning solvent forms on an exterior surface of the electrospray emitter while operating the electrospray emitter in the dripping mode of operation; and (c) causing the droplet to dislodge from the electrospray emitter exterior.
    Type: Grant
    Filed: November 21, 2019
    Date of Patent: August 10, 2021
    Assignee: Thermo Finnigan LLC
    Inventors: Joshua A. Silveira, Michael L. Poltash, Wei Wei, Eloy R. Wouters
  • Patent number: 11075063
    Abstract: A method of mass spectrometry is disclosed comprising: performing a plurality of cycles of operation during a single experimental run, wherein each cycle comprises: mass selectively transmitting precursor ions of a single mass, or range of masses, through or out of a mass separator or mass filter at any given time, wherein the mass separator or mass filter is operated such that the single mass or range of masses transmitted therefrom is varied with time; and mass analysing ions.
    Type: Grant
    Filed: June 24, 2020
    Date of Patent: July 27, 2021
    Assignee: Micromass UK Limited
    Inventors: Keith Richardson, Jason Lee Wildgoose
  • Patent number: 11075064
    Abstract: An amplification system includes a first amplification module, a second amplification module, a third amplification module I, a fourth amplification module I, a first load, a third amplification module II, a fourth amplification module II and a second load. An output terminal of the first amplification module is connected to an input terminal of the second amplification module; output terminals of the second amplification module are connected to an input terminal of the third amplification module I and an input terminal of the third amplification module II. An output terminal of the third amplification module I is connected to an input terminal of the first load through the fourth amplification module I. An output terminal of the third amplification module II is connected to an input terminal of the second load through the fourth amplification module II.
    Type: Grant
    Filed: August 3, 2018
    Date of Patent: July 27, 2021
    Assignee: SHANGHAI YUDA INDUSTRIAL CO., LTD.
    Inventors: Bing Xue, Jian Jiang, Jiajia Yu, Xiaojun Qi, Bo Hu
  • Patent number: 11056327
    Abstract: Certain configurations of systems and methods that can detect inorganic ions and organic ions in a sample are described. In some configurations, the system may comprise one, two, three or more mass spectrometer cores. In some instances, the mass spectrometer cores can utilize common components such as gas controllers, processors, power supplies and vacuum pumps. In certain configurations, the systems can be designed to detect both inorganic and organic analytes comprising a mass from about three atomic mass units, four atomic mass units or five atomic mass units up to a mass of about two thousand atomic mass units.
    Type: Grant
    Filed: April 14, 2019
    Date of Patent: July 6, 2021
    Assignee: PerkinElmer Health Sciences Canada, Inc.
    Inventors: Tak Shun Cheung, Chui Ha Cindy Wong, Hamid Badiei, William Fisher
  • Patent number: 11049709
    Abstract: A method of mass spectrometry or ion mobility spectrometry is disclosed comprising: providing ions towards an ion storage region; selecting a target maximum charge desired to be stored within the ion storage region at any given time; and reducing the ion current passing to the ion storage region such that the ions entering the ion storage region do not cause the total charge within the storage region to rise above said target maximum charge. The step of reducing the ion current passing to the ion storage region comprises: temporally separating the ions according to their ion mobility in an ion mobility separator; and mass filtering the ions according to mass to charge ratio with a mass filter. Said steps of separating and mass filtering the ions result in substantially only target ions having selected combinations of ion mobility and mass to charge ratio being transmitted towards the ion storage region.
    Type: Grant
    Filed: November 11, 2014
    Date of Patent: June 29, 2021
    Assignee: MICROMASS UK LIMITED
    Inventors: Kevin Giles, Martin Raymond Green, Keith Richardson, Jason Lee Wildgoose
  • Patent number: 11049707
    Abstract: The present invention is directed to a method and device to desorb an analyte using heat to allow desorption of the analyte molecules, where the desorbed analyte molecules are ionized with ambient temperature ionizing species. In various embodiments of the invention a current is passed through a mesh upon which the analyte molecules are present. The current heats the mesh and results in desorption of the analyte molecules which then interact with gas phase metastable neutral molecules or atoms to form analyte ions characteristic of the analyte molecules.
    Type: Grant
    Filed: April 16, 2020
    Date of Patent: June 29, 2021
    Assignee: IONSENSE, INC.
    Inventors: Jordan Krechmer, Brian D. Musselman
  • Patent number: 11043370
    Abstract: Disclosed herein are embodiments of a system for selectively ionizing samples that may comprise a plurality of different analytes that are not normally detectable using the same ionization technique. The disclosed system comprises a unique split flow tube that can be coupled with a plurality of ionization sources to facilitate using different ionization techniques for the same sample. Also disclosed herein are embodiments of a method for determining the presence of analytes in a sample, wherein the number and type of detectable analytes that can be identified is increased and sensitivity and selectivity are not sacrificed.
    Type: Grant
    Filed: April 28, 2020
    Date of Patent: June 22, 2021
    Assignee: Battelle Memorial Institute
    Inventors: Elizabeth Denis, Brian Dockendorff, Robert Ewing, Eric Wilcox Freeburg, Kelsey Morrison, Megan Nims, Blandina Valenzuela
  • Patent number: 11036297
    Abstract: Provided is a tactile feedback device including a tactile transmission element having an enclosed space inside, the tactile transmission element including a compression part which is compressed toward the enclosed space by an electrostatic force generated by the application of voltage, and a tactile part which transmits tactile sensation to a user by expansion with movement of air by the compression.
    Type: Grant
    Filed: July 3, 2019
    Date of Patent: June 15, 2021
    Assignees: Korea Institute of Science and Technology, Center of Human-Centered Interaction for Coexistence
    Inventors: Youngsu Cha, Kahye Song, Jung Min Park, Bum-Jae You
  • Patent number: 11037774
    Abstract: A method is disclosed comprising obtaining physical or other non-mass spectrometric data from one or more regions of a target using a probe. The physical or other non-mass spectrometric data may be used to determine one or more regions of interest of the target. An ambient ionisation ion source may then used to generate an aerosol, smoke or vapour from one or more regions of the target.
    Type: Grant
    Filed: March 7, 2016
    Date of Patent: June 15, 2021
    Assignee: Micromass UK Limited
    Inventors: Steven Derek Pringle, Emrys Jones, Michael Raymond Morris, Julia Balog, James Ian Langridge, Keith Richardson, Daniel Simon, Lajos Godorhazy, Daniel Szalay, Zoltan Takats
  • Patent number: 11031224
    Abstract: An ion guiding device includes ring electrodes with a same size disposed in parallel; wherein a connection line of centers of the ring electrodes is defined as an axis, a normal of a plane where any of the ring electrodes is located and a tangent line of the axis at a center of the ring electrode form an included angle being a range of (0, 90) degrees; a radio-frequency voltage source, for applying an out-phase radio-frequency voltage on a neighboring ring electrode along the axis, so that ions are confined inside the ring electrode during a transmission process; and a direct-current voltage source, applying a direct-current voltage with an amplitude changing along the axis on the ring electrode, so that the ions are transmitted along the axis and focused to a position closer to an inner surface of the ring electrode along a direction of the normal.
    Type: Grant
    Filed: May 30, 2017
    Date of Patent: June 8, 2021
    Assignee: SHIMADZU CORPORATION
    Inventors: Keke Wang, Xiaoqiang Zhang, Wenjian Sun
  • Patent number: 11031219
    Abstract: Systems and methods are disclosed for determining if the dynamic range of quantitation in mass spectrometry can be extended. A DIA method is performed on a sample for a compound of interest at each acquisition time of a plurality of acquisition times. A plurality of product ion spectra are produced for each window of two or more precursor ion mass selection windows. A known product ion of the compound of interest is selected. Two or more XICs are calculated from two or more different precursor ion windows for the known product ion. A ratio of one XIC of the two or more XICs to at least one other XIC of the two or more XICs is calculated. If the ratio is above a threshold, the XIC is used in the quantitation. If not, two or more XICs can be combined into a single XIC that is used for the quantitation.
    Type: Grant
    Filed: June 9, 2017
    Date of Patent: June 8, 2021
    Assignees: DH Technologies Development Pte. Ltd.
    Inventors: Ronald Francis Bonner, Lyle Lorrence Burton, Gérard Hopfgartner, Gordana Ivosev
  • Patent number: 11031232
    Abstract: A method of injecting ions into an ion storage device, comprising: providing an RF trapping field in the ion storage device that defines a trapping volume in the ion storage device by applying one or more RF voltages to one or more trapping electrodes; providing a gas in the trapping volume; injecting ions into the trapping volume through an aperture in an end electrode located at a first end of the ion storage device, the end electrode having a DC voltage applied thereto; reflecting the injected ions at a second end of the ion storage device, opposite to the first end, thereby returning the ions to the first end; and ramping the DC voltage applied to the end electrode during the period between injecting the ions through the aperture and the return of the ions to the first end, such that by the time the ions return to the first end for a first time a potential barrier is established by the ramped DC voltage that prevents returning ions from striking the end electrode.
    Type: Grant
    Filed: July 9, 2020
    Date of Patent: June 8, 2021
    Assignee: Thermo Fisher Scientific (Bremen) GmbH
    Inventors: Hamish Stewart, Alexander A. Makarov, Christian Albrecht Hock
  • Patent number: 11031216
    Abstract: A data acquisition method for a mass spectrometer includes providing at least one ion source for generating ions; not fragmenting or less fragmenting the ions when a collision cell is in a first working mode; recording a mass spectrum of the ions generated in the first working mode; selecting more than one ion from the ions, the more than one ion being distributed in a plurality of discontinuous mass-to-charge ratio channels; partially fragmenting the selected ions when the collision cell is in a second working mode; recording a mass spectrum of the ions generated in the second working mode; and, repetitively executing the above steps for several times. The ions distributed in the discontinuous mass-to-charge ratio channels is always selected during the subsequent repeated execution, until the ion intensity of the selected ions is less than a set value.
    Type: Grant
    Filed: May 30, 2017
    Date of Patent: June 8, 2021
    Assignee: SHIMADZU CORPORATION
    Inventors: Yunqing Huang, Wenjian Sun, Xiaoqiang Zhang
  • Patent number: 11031205
    Abstract: A device for generating negative ions comprises: a) an ionizer (14) including a heatable ionizer surface; b) a heater (60) for heating said ionizer whereby positive ions (30) are generated at said ionizer surface (14e); c) a target (34) including a material for generating negative ions when said positive ions impigne on said material; wherein d) said ionizer is arranged opposite the target; e) said target is electrically negatively biased in respect to said ionizer; f) said ionizer comprises an aperture (22) through which said generated negative ions are extracted from said target to generate a beam (50) of negative ions; and wherein g) said ionizer surface (14e) is planar.
    Type: Grant
    Filed: February 4, 2020
    Date of Patent: June 8, 2021
    Assignee: GEORG-AUGUST-UNIVERSITÄT GÖTTINGEN STIFTUNG ÖFFENTLICHEN RECHTS, UNIVERSITÄTSMEDIZIN
    Inventors: Hans Hofsäss, Felipe Lipp Bregolin, Dimitar Yordanov
  • Patent number: 11024495
    Abstract: A plurality of MRM transitions to be used to monitor a sample are received and divided into two or more contiguous groups. At least one sentinel transition is selected in each group that identifies a next group of the two or more contiguous groups that is to be monitored. A first group of the two or more contiguous groups is placed on a duty cycle list of the tandem mass spectrometer. One or more compounds are separated from the sample and ionized, producing an ion beam. A series of MRM transitions read from the duty cycle list are executed on the ion beam by the tandem mass spectrometer. When at least one sentinel transition of the first group is detected, a next group identified by the sentinel transition is placed on the list.
    Type: Grant
    Filed: February 14, 2020
    Date of Patent: June 1, 2021
    Inventor: Jerome Lemoine
  • Patent number: 11011359
    Abstract: Techniques for performing data acquisition and analysis are described. A multi-mode acquisition strategy may be performed which iteratively selects mass isolation windows of different sizes in different scan cycles to acquire experimental data. The mass isolation windows selected may provide for acquiring elevated energy scan data for a defined set of m/z values. Single scan data analysis may be performed. Data analysis may include forming precursor charge clusters, chaining precursor charge clusters having the same mass to charge ratio to form peaks profiles, and using criteria to align precursor and product ions of the experimental data. Unsupervised and supervised clustering may be performed using a database and composite ion spectra formed from experimental data. Also described are a small molecule acquisition enhancement and additional techniques applicable for biopharmaceutical and other applications.
    Type: Grant
    Filed: January 17, 2020
    Date of Patent: May 18, 2021
    Assignee: Waters Technologies Corporation
    Inventors: Scott J. Geromanos, Steven J. Ciavarini, Curt Devlin
  • Patent number: 11011345
    Abstract: The present disclosure relates to a charged particle beam device intended to appropriately measure the amount of foreign substances in a vacuum chamber. As one aspect for achieving the above object, proposed is a charged particle beam device including a charged particle beam column (9) configured to irradiate a sample with a charged particle beam, vacuum chambers (1, 2) configured to create a vacuum around the sample, a plurality of electrodes (12) arranged in the vacuum chambers, and a capacitance measuring device (13) for measuring the capacitance between the plurality of electrodes.
    Type: Grant
    Filed: February 10, 2020
    Date of Patent: May 18, 2021
    Assignee: Hitachi High-Tech Corporation
    Inventors: Takumi Hatakeyama, Naoya Ishigaki
  • Patent number: 11011364
    Abstract: An apparatus configured to produce an image charge/current signal representative of trapped ions undergoing oscillatory motion. The apparatus includes: an electrostatic ion trap configured to trap ions such that the trapped ions undergo oscillatory motion in the electrostatic ion trap; an image charge/current detector configured to obtain an image charge/current signal representative of trapped ions undergoing oscillatory motion in the electrostatic ion trap, wherein the electrostatic ion trap configured to trap ions such that the image charge/current signal in the time domain repeats, for ions of a given mass/charge ratio m, at a frequency fsig(m) [Hz] with a signal period Tsig(m) [s]. The image charge/current detector includes one or more pickup electrodes configured to obtain the image charge/current signal. The one or more pickup electrodes are arranged to detect two signal pulses caused by ions having the given mass/charge ratio m within each signal period Tsig(m).
    Type: Grant
    Filed: June 26, 2020
    Date of Patent: May 18, 2021
    Assignee: SHIMADZU CORPORATION
    Inventors: Aleksandr Rusinov, Li Ding
  • Patent number: 11011360
    Abstract: An analyzer apparatus includes: an ionization unit that ionizes molecules to analyze; a filter unit that forms a field for selectively passing ions generated by the ionization unit; a detector unit that detects ions that have passed through the filter unit; an ion drive circuitry that electrically drives the ionization unit; a field drive circuitry that electrically drives the filter unit; and a control unit that controls outputs of the ion drive circuitry and the field drive circuitry, wherein the control unit controls the ion drive circuitry to ramp up and down a filament voltage supplied to a filament of the ionization unit when the analyzer apparatus starts and stops.
    Type: Grant
    Filed: October 20, 2020
    Date of Patent: May 18, 2021
    Assignee: ATONARP INC.
    Inventors: Prakash Sreedhar Murthy, Anoop R. Hegde, Takeshi Sato
  • Patent number: 11004669
    Abstract: A method and apparatus for analyzing samples using mass spectrometry are disclosed. The apparatus includes a reaction device configured to dissociate sample ions into fragments by reacting the sample ions with a charged species (e.g., electrons) such as through ECD, EID, or EIEIO. The kinetic energy of the charged species is such that the fragments may be detected and produce spectra that allow for the determination of isomeric species in the sample and the location of double bonds and/or the orientation of those double bonds within the sample molecules. The fragments may include radical fragments and non-radical fragments. Spectra resulting from analysis of the fragments may allow for the determination of the oxygen-radical fragments resulting from the dissociation of the sample molecules as confirmation of the presence of those radical fragments.
    Type: Grant
    Filed: December 15, 2016
    Date of Patent: May 11, 2021
    Assignee: DH Technologies Development Pte. Ltd.
    Inventors: Takashi Baba, Paul Baker, John Lawrence Campbell, Yves Le Blanc
  • Patent number: 11004649
    Abstract: The invention provides an electron-impact ion source device having high brightness as compared to known Nier-type ion sources, while providing similar advantages in terms of flexibility of the generated ion species, for example. The ionization chamber of the device operates at high pressures and provides for a large number of interactions between the electron beam and the gas molecules.
    Type: Grant
    Filed: February 28, 2018
    Date of Patent: May 11, 2021
    Assignee: LUXEMBOURG INSTITUTE OF SCIENCE AND TECHNOLOGY (LIST)
    Inventors: Olivier De Castro, Serge Della-Negra, David Dowsett, Tom Wirtz
  • Patent number: 10998179
    Abstract: Methods and systems for delivering a liquid sample to an ion source for the generation of ions and subsequent analysis by mass spectrometry are provided herein. In accordance with various aspects of the present teachings, MS-based systems and methods are provided in which the flow of desorption solvent within a sampling probe fluidly coupled to an ion source can be selectively controlled such that one or more analyte species can be desorbed from a sample substrate inserted within the sampling probe within a decreased volume of desorption solvent for subsequently delivery to the ion source. In various aspects, sensitivity can be increased due to higher desorption efficiency (e.g., due to increased desorption time) and/or decreased dilution of the desorbed analytes.
    Type: Grant
    Filed: October 12, 2017
    Date of Patent: May 4, 2021
    Assignee: DH Technologies Development Pte. Ltd.
    Inventors: Don W. Arnold, Thomas R. Covey, Chang Liu
  • Patent number: 10998163
    Abstract: The disclosure describes various aspects of a cryogenic trapped-ion system. In an aspect, a method is described that includes bringing a chain of ions in a trap at a cryogenic temperature, the trap being a micro-fabricated trap, and performing quantum computations, simulations, or both using the chain of ions in the trap at the cryogenic temperature. In another aspect, a method is described that includes establishing a zig-zag ion chain in the cryogenic trapped-ion system, detecting a change in a configuration of the zig-zag ion chain, and determining a measurement of the pressure based on the detection in the change in configuration. In another aspect, a method is described that includes measuring a low frequency vibration, generating a control signal based on the measurement to adjust one or more optical components, and controlling the one or more optical components using the control signal.
    Type: Grant
    Filed: May 9, 2019
    Date of Patent: May 4, 2021
    Assignee: UNIVERSITY OF MARYLAND, COLLEGE PARK
    Inventors: Christopher Monroe, Guido Pagano, Paul W. Hess, Harvey B. Kaplan, Wen Lin Tan, Philip J. Richerme
  • Patent number: 10998180
    Abstract: Disclosed is a plasma sampling interface for an inductively coupled mass spectrometer, comprising a housing having entry and exit openings for respectively introducing and releasing ions from the chamber, and a sampler mounted on the housing so as to be disposed adjacent to plasma generated by an inductively coupled plasma source, wherein the entry opening is provided in a cooling plate that is integral to the housing and that is formed from bronze. Also disclosed is a bronze cooling plate for receiving and cooling a plasma sampler in an inductively coupled mass spectrometer, and a mass spectrometer that comprises a plasma sampling interface as disclosed.
    Type: Grant
    Filed: November 14, 2019
    Date of Patent: May 4, 2021
    Assignee: Thermo Fisher Scientific (Bremen) GmbH
    Inventor: Joachim Hinrichs
  • Patent number: 10989689
    Abstract: A gas chromatography-ion mobility spectrometry detector and a hyphenated apparatus, the gas chromatography-ion mobility spectrometry detector comprises a gas chromatography mechanism and an ion mobility spectrometry mechanism. The gas chromatography mechanism comprises a chromatographic column and a sample injection port. The ion mobility spectrometry mechanism comprises a mobility tube and a connecting body, while a metal connection plate of the connecting body comprises a chromatographic metal plate, an ion mobility metal plate and a semipermeable membrane; on the ion mobility metal plate there are provided an ion mobility sample and carrier gas inlet, an ion mobility sample chamber and a sample injection port; the chromatography sample chamber and the ion mobility sample chamber are separated by semipermeable membrane.
    Type: Grant
    Filed: December 28, 2018
    Date of Patent: April 27, 2021
    Assignee: NUCTECH COMPANY LIMITED
    Inventors: Qingjun Zhang, Weiping Zhu, Yuanjing Li, Zhiqiang Chen, Ziran Zhao, Yinong Liu, Yaohong Liu, Qiufeng Ma, Ge Li, Biao Cao, Nan Bai
  • Patent number: 10985003
    Abstract: The present invention provides an analysis method for determining halogens in geological samples by ICP-MS. The method includes following steps: weighing a geological sample and ammonium bifluoride in a sample dissolving tank, tightening the sample dissolving tank, and shaking; then heating the sample dissolving tank in a drying oven, and setting a temperature of the drying oven as 200-220° C. and heating time as 1-2 hours; cooling the sample dissolving tank to room temperature so as to obtain a solid mixture after heating is ended, adding ammonium hydroxide into the solid mixture, centrifuging, removing a precipitate, and collecting the supernatant; adding an internal standard solution into the supernatant, and uniformly mixing; and optimizing the ICP-MS to an optimal state, testing content of chlorine in the supernatant under a condition of medium resolution m/?m=4000, and testing content of bromine and iodine in the supernatant under a condition of low resolution m/?m=300.
    Type: Grant
    Filed: March 26, 2020
    Date of Patent: April 20, 2021
    Assignee: China University of Geosciences, Wuhan
    Inventors: Zhaochu Hu, Tao He, Wen Zhang, Haihong Chen, Ming Li, Yongsheng Liu
  • Patent number: 10984976
    Abstract: An ion trap chip, which may be used for quantum information processing and the like, includes an integrated microwave antenna. The antenna is formed as a radiator connected by one of its ends to the center trace of a microwave transmission line and connected by its other end to a current return path through a ground trace of the microwave transmission line. The radiator includes several parallel, coplanar radiator traces connected in series. The radiator traces are connected such that they all carry electric current in the same direction, so that collectively, they simulate a single, unidirectionally flowing sheet of current. In embodiments, induced currents in underlying metallization planes are suppressed by parallel slots that extend in a direction perpendicular to the radiator traces.
    Type: Grant
    Filed: August 18, 2020
    Date of Patent: April 20, 2021
    Assignee: National Technology & Engineering Solutions of Sandia, LLC
    Inventors: Christopher Nordquist, Matthew G. Blain, Peter Lukas Wilhelm Maunz, Christopher W. Berry
  • Patent number: 10984996
    Abstract: This application discloses a background subtraction-mediated data dependent acquisition method useful in mass spectrometry analysis. The method includes subtraction of background data from precursor ion spectra of a sample in real-time to obtain mass data of component(s) of interest and performs data-dependent acquisition on the component(s) of interest based on the resultant mass data from the background subtraction step. The present invention also encompasses mass spectrometer systems capable of background subtraction-mediated data-dependent acquisition and computer programs adapted for use in the background-subtraction-mediated data-dependent acquisition. The invention thus provides highly sensitive data-dependent acquisition for minor components of interest in a sample.
    Type: Grant
    Filed: January 18, 2012
    Date of Patent: April 20, 2021
    Assignee: MassDefect Technologies, LLC
    Inventor: Xin Wang
  • Patent number: 10985002
    Abstract: Certain configurations of an ionization source comprising a multipolar rod assembly are described. In some examples, the multipolar rod assembly can be configured to provide a magnetic field and a radio frequency field into an ion volume formed by a substantially parallel arrangement of rods of the multipolar rod assembly. The ionization source may also comprise an electron source configured to provide electrons into the ion volume of the multipolar rod assembly to ionize analyte introduced into the ion volume. Systems and methods using the ionization source are also described.
    Type: Grant
    Filed: June 11, 2019
    Date of Patent: April 20, 2021
    Assignee: PerkinElmer Health Sciences, Inc.
    Inventor: Adam Patkin
  • Patent number: 10959708
    Abstract: The present invention provides for a system, method, and device for analyzing, localizing and/or identifying tissue types. The method includes analyzing, localizing and/or identifying one or more tissue samples, characterized in that the method comprises: (a) generating gaseous tissue particles from a site in the one or more tissue samples, (b) transporting the gaseous tissue particles from the site to an analyser, (c) using the analyser for generating tissue-related data based on the gaseous tissue particles, and (d) analyzing, localizing and/or identifying the one or more tissue samples based on the tissue-related data. The invention can either be used in close conjunction with a surgical procedure, when one or more surgical tools are an integrated part of ionization, or as a separate mass spectrometric probe for the analysis of one or more tissue parts.
    Type: Grant
    Filed: July 1, 2019
    Date of Patent: March 30, 2021
    Assignee: Micromass UK Limited
    Inventor: Zoltan Takats