Ionic Separation Or Analysis Patents (Class 250/281)
  • Patent number: 10811241
    Abstract: The invention generally relates to methods for analyzing an analyte in a sample. In certain embodiments, the methods involve providing a capture module, the module configured to capture an analyte in a sample in an ambient environment and generate ions of the analyte, wherein the capture module comprises a cartridge and a porous substrate within the cartridge that is connected to a voltage source, and wherein the porous substrate further comprises an internal standard; capturing the analyte in the sample to the porous substrate of the capture module; generating ions of the analyte and the internal standard held by the porous substrate via the voltage source that is coupled to the porous substrate; and analyzing the generated ions of the analyte and the internal standard in a mass analyzer that is operably coupled to the capture module.
    Type: Grant
    Filed: March 4, 2020
    Date of Patent: October 20, 2020
    Assignee: Purdue Research Foundation
    Inventors: Robert Graham Cooks, Ahmed Mohamed Hamid, Alan Keith Jarmusch, Zheng Ouyang
  • Patent number: 10811259
    Abstract: The disclosure discloses an ion injecting device, and an ion injecting method thereof, where the ion injecting device is modified by adding a vacant baffle between a process chamber and an analyzing magnet. Moreover the vacant baffle is closed before an engineer opens the process chamber for cleaning, so that the process chamber is separated from the analyzing magnet, thus maintaining a vacuum environment in the analyzing magnet. Subsequently only a vacuum environment in the process chamber will be created again.
    Type: Grant
    Filed: August 10, 2018
    Date of Patent: October 20, 2020
    Assignees: BOE Technology Group Co., Ltd., Chengdu BOE Optoelectronics Technology Co., Ltd.
    Inventors: Xuefeng Lv, Da Zhou, Kang Luo, Zailong Mo
  • Patent number: 10804092
    Abstract: An analysis device for a gaseous sample includes a mass spectrometer (6) having a measurement chamber and an inlet (5) leading into the measurement chamber, and a laser irradiation unit (30, 3). The analysis device is designed to convey the gaseous sample to the inlet by a flow including the gaseous sample. The laser irradiation unit (30, 3) is designed to ignite a plasma (1) by a laser beam (2?) in the flow (4).
    Type: Grant
    Filed: July 25, 2017
    Date of Patent: October 13, 2020
    Assignee: Bundesrepublik Deutschland, Vertreten Durch Den Bundesminister Für Wirtschaft Und Energie
    Inventors: Jens Riedel, Andreas Bierstedt
  • Patent number: 10804087
    Abstract: A mass analyzer includes a main substrate, an upper substrate adhered to the main substrate, and a lower substrate. A mass analysis room (cavity) is formed in the main substrate and penetrates from an upper surface of the first main substrate to a lower surface of the first main substrate. A vertical direction (Z direction) to the main substrate by the upper substrate, both sides of the lower substrate, a travelling direction (X direction) of charged particles and a right angle to the Z direction by the main substrate, and both sides of a right-angled direction (Y to Z direction) and the X direction by a side surface of the main substrate are surrounded. A central hole is open in the side plate of the main substrate that the charged particles enter. The charged particles enter the mass analysis room through the central hole formed in the first main substrate.
    Type: Grant
    Filed: February 13, 2019
    Date of Patent: October 13, 2020
    Inventor: Takashi Hosaka
  • Patent number: 10804091
    Abstract: Methods and systems of identifying two or more elements in a single individual particle are described. In some examples, an optical emission from each of an ionized first element and an ionized second element can simultaneously be detected to identify at least a first element in a particle from a plurality of particles using the optical emission from the ionized first element, and to identify at least a second element in the particle from the plurality of particles using the optical emission from the second ionized element. The identified first element and the identified second element can be used to identify a source of the particle from a plurality of particles.
    Type: Grant
    Filed: December 4, 2018
    Date of Patent: October 13, 2020
    Assignee: PerkinElmer Health Sciences Canada, Inc.
    Inventors: Chady Stephan, Samad Bazargan
  • Patent number: 10794861
    Abstract: The invention proposes a methods and devices for tandem ion mobility spectrometry using at least one TIMS analyzers (TIMS=trapping ion mobility spectrometry), in particular in the field of structural biology.
    Type: Grant
    Filed: January 30, 2019
    Date of Patent: October 6, 2020
    Inventors: Melvin Andrew Park, Mark Ridgeway, Christian Bleiholder, Fanny Caroline Liu
  • Patent number: 10794813
    Abstract: Particle detection device comprising a support, a platform for receiving particles, four beams suspending the platform from the support, such that the platform can be made to vibrate, means for making said platform vibrate at a resonance frequency, means for detecting the displacement of the platform in a direction of displacement. Each beam has a length l, a width L and a thickness e and the platform has a dimension in the direction of displacement of the platform and in which in a device with out of plane mode l?10×L and the dimension of each beam in the direction of displacement of the platform is at least 10 times smaller than the dimension of the platform in the direction of displacement.
    Type: Grant
    Filed: January 2, 2019
    Date of Patent: October 6, 2020
    Assignee: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
    Inventors: Sebastien Hentz, Marc Sansa Perna
  • Patent number: 10794816
    Abstract: The disclosure relates to a method for determining a hydrodynamic size of an object, such as a nano-sized object, said method comprising the steps of: —providing a fluid interface, —linking said object to said fluid interface thereby providing a linked object, whereby the movement of said linked object is restricted by virtue of being linked to said fluid interface, —providing and determining a hydrodynamic shear force that acts on said linked object, —tracking the movement of said linked object, and —calculating the hydrodynamic size of the object using the Einstein-Smoluchowski relation.
    Type: Grant
    Filed: December 2, 2016
    Date of Patent: October 6, 2020
    Assignee: GOTHENBURG SENSOR DEVICES AB
    Inventors: Fredrik Höök, Stephan Block, Björn Johansson Fast, Anders Lundgren
  • Patent number: 10790807
    Abstract: A method of performing a computational process using a quantum computer includes generating a laser pulse sequence comprising a plurality of laser pulse segments used to perform an entangling gate operation on a first trapped ion and a second trapped ion of a plurality of trapped ions that are aligned in a first direction, each of the trapped ions having two frequency-separated states defining a qubit, and applying the generated laser pulse sequence to the first and second trapped ions. Each of the plurality of laser pulse segments has a pulse shape with ramps formed using a spline at a start and an end of each of the plurality of laser pulse segments.
    Type: Grant
    Filed: March 12, 2020
    Date of Patent: September 29, 2020
    Assignee: IONQ, INC.
    Inventors: Shantanu Debnath, Jason M. Amini, Jwo-Sy Chen, Neal Pisenti
  • Patent number: 10790132
    Abstract: The present invention provides a time-of-flight mass spectrometer (TOFMS) taken measures for preventing a deterioration in accuracy caused at the time of transportation to an installation site.
    Type: Grant
    Filed: January 25, 2017
    Date of Patent: September 29, 2020
    Assignee: SHIMADZU CORPORATION
    Inventor: Yusuke Sakagoshi
  • Patent number: 10788453
    Abstract: An ion mobility spectrometer includes a drift tube responsive to application of at least a first voltage to establish a first electric field therein configured to cause ions within the drift tube to move along and about the drift tube while separating from one another as a function of ion mobility, and a transition region coupled to opposed ends of the first drift tube such that the drift tube and the transition region together define a closed path. The transition region is responsive to application of at least a second voltage to cause the ions to move along and about the closed path, to application of at least a third voltage to selectively pass ions into the drift tube and to application of at least a fourth voltage to selectively pass ions out of the drift tube.
    Type: Grant
    Filed: March 19, 2019
    Date of Patent: September 29, 2020
    Assignee: The Trustees Of Indiana University
    Inventors: David E. Clemmer, Michael A. Ewing
  • Patent number: 10788449
    Abstract: A method of mass spectrometry or ion mobility spectrometry is disclosed in which analyte ions of a desired charge state are isolated. The method comprises: separating analytes according to their electrophoretic mobility; ionising the analytes; and mass filtering the resulting analyte ions, wherein the mass to charge ratios of the ions transmitted by a mass filter are varied as a function of the electrophoretic mobility and according to a predetermined relationship such that substantially only ions having said desired charge state are transmitted by the mass filter.
    Type: Grant
    Filed: April 4, 2019
    Date of Patent: September 29, 2020
    Assignee: Micromass UK Limited
    Inventors: Martin Raymond Green, Keith Richardson, Jason Lee Wildgoose
  • Patent number: 10782271
    Abstract: Synthetic Cannabinoids are the most complex branch of designer drugs encountered in forensic chemistry. A screening method has been developed that can accurately identify the correct structural category of an unknown Synthetic Cannabinoid. Knowledge of this information is very important when no reference data or standards are available since certain sub-categories contain Schedule I Controlled Dangerous Substances. The Bridge portion of these molecules present a unique carbonyl band cluster within a small 200 wavenumber interval of the mid-infrared region that can only exist in vapor phase through GC/FTIR light-pipe technology or heated static vapor cell FTIR. This special relationship is not applicable to any other forms of solid phase vibrational spectroscopy (FTIR, RAMAN) including GC/FTIR solid-deposit techniques.
    Type: Grant
    Filed: January 14, 2019
    Date of Patent: September 22, 2020
    Inventor: Lewis Wayne Smith, III
  • Patent number: 10782211
    Abstract: A sampling device and an inspection apparatus are disclosed. In one aspect, an example gathering and sampling device includes a cylindrical outer housing and an inner housing disposed within the cylindrical outer housing, a cyclone chamber is formed between the cylindrical outer housing and the inner housing to generate a cyclone by injecting a gas flow into the cyclone chamber. The gathering and sampling device further includes an outer chamber body, and a plurality of gas injection orifices formed in the first inner housing end opening of the inner housing and configured to inject a gas towards a substantial center of a circular region defined by an end face of the first outer housing end opening of the cylindrical outer housing.
    Type: Grant
    Filed: December 29, 2017
    Date of Patent: September 22, 2020
    Assignees: Tsinghua University, Nuctech Company Limited
    Inventors: Qingjun Zhang, Yuanjing Li, Ziran Zhao, Ge Li, Biao Cao, Qiufeng Ma, Linxia Tan
  • Patent number: 10775242
    Abstract: A tracking and ranging system includes a thermal sensor device, a controller, a ranging device and a transmission device. The thermal sensor device is configured to capture a thermal image. The controller analyzes the thermal image to identify the main heat source from among the heat sources displayed in the thermal image, and obtain an offset distance between the center points of the main heat source and the thermal image. The ranging device is coupled to the controller. The transmission device loads the ranging device and is coupled to the controller. The controller controls the motion of the transmission device in accordance with the offset distance to correct the offset angle between the ranging device and the object corresponding to the main heat source. After correcting the offset angle, the ranging device detects a first distance to the object by transmitting energy and receiving reflected energy.
    Type: Grant
    Filed: January 24, 2019
    Date of Patent: September 15, 2020
    Assignee: QUANTA COMPUTER INC.
    Inventors: Ming-Hong Ni, Chien-Hung Liu
  • Patent number: 10777401
    Abstract: The present invention relates to the technical field of ionizing a gaseous substance, in particular the ionizing or ionization of a gaseous substance in preparation for its analysis. A device is intended to make a discharge gas and a test substance ionizable in a flow-through mode without essentially destroying or fragmenting the sample substance. In order to avoid a high expenditure in terms of construction and equipment, the device is intended to be usable under ambient conditions and to ensure a high sensitivity in a possible analysis of an ionized substance. To this end, an ionizing device is used for flow-through ionization of a discharge gas and of a sample substance at an absolute pressure of more than 40 kPa in the ionizing device during ionization. The ionizing device comprises an inlet, an outlet, a first electrode, a dielectric element and a second electrode.
    Type: Grant
    Filed: December 14, 2016
    Date of Patent: September 15, 2020
    Assignee: PLASMION GMBH
    Inventor: Jan-Christoph Wolf
  • Patent number: 10770280
    Abstract: There is proposed a right angle time-of-flight detector comprising a conductive converter for emitting and accelerating secondary electrons, a magnetic field formed by at least one magnet for deflecting the secondary electrons at a right angle and a sealed photo-multiplier. The detector is expected to provide an extended resource and dynamic range and may be fit into tight assemblies, such as MR-TOF MS.
    Type: Grant
    Filed: March 31, 2015
    Date of Patent: September 8, 2020
    Assignee: LECO Corporation
    Inventors: Anatoly N. Verenchikov, Aleksey Vorobyev
  • Patent number: 10768151
    Abstract: Processing mass spectral data may include performing one or more experiments using one or more samples, each experiment including mass analysis using a mass spectrometer; acquiring one or more raw mass spectral data sets as a result of performing the one or more experiments; receiving selection criteria; filtering the one or more raw mass spectral data sets in accordance with the selection criteria; and generating a chromatogram as a result of said filtering, wherein the chromatogram displays signal intensity as a function of scan time for a plurality of scan times and includes a non-zero signal intensity at each scan time only if, at the scan time, the selection criteria is met and otherwise the chromatogram includes a zero signal intensity at the scan time. The mass spectrometer may alternate between low and elevated energy modes and acquire two of the raw mass spectral data sets concurrently.
    Type: Grant
    Filed: September 11, 2015
    Date of Patent: September 8, 2020
    Assignee: Waters Technologies Corporation
    Inventor: Douglas M. Stevens
  • Patent number: 10763079
    Abstract: A dual beam system having a charged particle beam (CPB) lens and an ion beam column can operate in an analysis mode. In the analysis mode, an ion beam from the ion beam column can be deflected by the CPB into one or more component beams including a primary ion beam and one or more non-primary ion beams. The dual-beam system can identify the ion species of the non-primary ion beams.
    Type: Grant
    Filed: February 19, 2019
    Date of Patent: September 1, 2020
    Assignee: FEI Company
    Inventors: Jeremy Graham, Lukas Kral
  • Patent number: 10761083
    Abstract: The invention generally relates to a sample dispenser including an internal standard and methods of use thereof.
    Type: Grant
    Filed: November 21, 2016
    Date of Patent: September 1, 2020
    Assignee: Purdue Research Foundation
    Inventors: Zheng Ouyang, He Wang, Nicholas E. Manicke, Robert Graham Cooks, Qian Yang, Jiangjiang Liu
  • Patent number: 10763098
    Abstract: An ion optical device includes one or more pairs of confinement electrode units arranged at two sides of a first direction; a power supply device for applying opposite radio-frequency voltages to the paired confinement electrode units respectively and forming thereon DC potentials distributed in a second direction orthogonal to the first direction to form a potential barrier herein over a length portion of the first direction; one first area and one second area positioned at two sides of the potential barrier in the second direction; and a control device connected with the power supply device for controlling an output thereof to change the potential barrier to manipulate the ions transported/stored in the first area being transferred to the second area through the potential barrier in ways based on the mass to charge ratio or mobility of the ions and continue being transported along the first direction.
    Type: Grant
    Filed: March 30, 2017
    Date of Patent: September 1, 2020
    Assignee: SHIMADZU CORPORATION
    Inventors: Gongyu Jiang, Wenjian Sun, Yupeng Cheng, Xiaoqiang Zhang
  • Patent number: 10755907
    Abstract: A method of producing a mass spectrum from a time-varying transient signal detected in a mass spectrometer, the method comprising: performing a Fourier transform of the transient signal to produce a first set of complex amplitudes wherein each of the complex amplitudes corresponds to a respective frequency of a first set of frequencies; generating a second set of complex amplitudes, wherein each of the complex amplitudes corresponds to a respective frequency of a second set of frequencies with a minimum spacing less than the inverse of the duration of the transient signal; optimizing the second set of complex amplitudes to produce an improved second set; generating a mass spectrum from at least some of the improved second set of complex amplitudes; wherein optimizing the second set of complex amplitudes to produce an improved second set of complex amplitudes is based on an objective function subject to some phase constraints.
    Type: Grant
    Filed: April 18, 2016
    Date of Patent: August 25, 2020
    Assignee: Thermo Fisher Scientific (Bremen) GmbH
    Inventors: Konstantin Aizikov, Dmitry Grinfeld, Alexander Makarov
  • Patent number: 10755914
    Abstract: A multipole assembly configured to be disposed in a mass spectrometer includes a plurality of elongate electrodes arranged about an axis extending along a longitudinal trajectory of the plurality of elongate electrodes and configured to confine ions radially about the axis, and a piezoelectric actuator configured to adjust a position of a first electrode included in the plurality of elongate electrodes.
    Type: Grant
    Filed: December 5, 2019
    Date of Patent: August 25, 2020
    Assignee: Thermo Finnigan LLC
    Inventors: Edward B. McCauley, Scott T. Quarmby, George B. Guckenberger, James M. Hitchcock
  • Patent number: 10755908
    Abstract: A system and method of mass spectrometry is provided. Ions from an ion source are stored in a first ion storage device and in a second ion storage device. Ions are ejected from the first ion storage device to a first mass analysis device during a first ejection time period, for analysis during a first analysis time period. Ions are ejected from the second ion storage device to a second mass analysis device during a second ejection time period. The ion storage devices are connected in series such that an ion transport aperture of the first ion storage device is in communication with an ion transport aperture of the second ion storage device. The first analysis time period and the second ejection time period at least partly overlap.
    Type: Grant
    Filed: March 26, 2019
    Date of Patent: August 25, 2020
    Assignee: Thermo Fisher Scientific (Bremen) GmbH
    Inventors: Alexander A. Makarov, Stevan R. Horning
  • Patent number: 10748753
    Abstract: An accelerator mass spectrometry system for measuring an isotopic ratio of a chemical element in a sample. The system includes an ion source generating a beam of negative ions of the chemical element containing ions of first and second isotopes of the chemical element, a first analyzer section, comprising a first mass analyzer; a tandem accelerator comprising a first accelerating section, a charge stripping section for converting the negative ions into positive ions, and a second accelerating section behind the charge stripping section. A second analyzer section includes a second mass analyzer and an electrostatic analyzer; a particle detector; and a controller system configured to control the first mass analyzer section and the second analyzer section such that the ions of the first and second isotopes traverse the tandem accelerator and ions of only one of the first and second isotopes enter the particle detector.
    Type: Grant
    Filed: June 13, 2019
    Date of Patent: August 18, 2020
    Assignee: HIGH VOLTAGE ENGINEERING EUROPA B.V.
    Inventor: Dirk Jozef Willem Mous
  • Patent number: 10748754
    Abstract: An isotope mass spectrometer including: an electron cyclotron resonance ion source, a front-end analysis device, a back-end analysis device and an ion detector; where the electron cyclotron resonance ion source is connected with the front-end analysis device, and is used for generating ion beams of multivalent charge states; the front-end analysis device is connected with the back-end analysis device, selects and separates the ion beams, and receives ion beams of constant, microscale and trace levels; the back-end analysis device is connected with the ion detector, and is used for eliminating a background of an isotope to be measured at an ultratrace level; and the ion detector is used for receiving ion beams of the ultratrace level, and carrying out energy measurement and separation on the ion beams of the ultratrace level, so as to obtain the isotope to be measured at the ultratrace level.
    Type: Grant
    Filed: September 6, 2018
    Date of Patent: August 18, 2020
    Inventor: Shan Jiang
  • Patent number: 10741378
    Abstract: Systems and methods described herein utilize a multipole ion guide that can receive ions from an ion source for transmission to downstream mass analyzers, while preventing unwanted/interfering/contaminating ions from being transmitted into the high-vacuum chambers of mass spectrometer systems. In various aspects, RF and/or DC signals can be provided to auxiliary electrodes interposed within a quadrupole rod set so as to control or manipulate the transmission of ions from the multipole ion guide.
    Type: Grant
    Filed: March 22, 2016
    Date of Patent: August 11, 2020
    Assignee: DH Technologies Development Pte. Ltd.
    Inventor: James W. Hager
  • Patent number: 10732157
    Abstract: Processing mass spectral data may include performing one or more experiments using one or more samples, each experiment including mass analysis using a mass spectrometer; acquiring one or more raw mass spectral data sets as a result of performing the one or more experiments; receiving selection criteria; filtering the one or more raw mass spectral data sets in accordance with the selection criteria; and generating a chromatogram as a result of said filtering, wherein the chromatogram displays signal intensity as a function of scan time for a plurality of scan times and includes a non-zero signal intensity at each scan time only if, at the scan time, the selection criteria is met and otherwise the chromatogram includes a zero signal intensity at the scan time. The mass spectrometer may alternate between low and elevated energy modes and acquire two of the raw mass spectral data sets concurrently.
    Type: Grant
    Filed: September 11, 2015
    Date of Patent: August 4, 2020
    Assignee: Waters Technologies Corporation
    Inventor: Douglas M. Stevens
  • Patent number: 10734210
    Abstract: A method of injecting analyte ions into a mass analyser comprises: injecting analyte ions of a first charge and counter ions of a second charge into an ion trap; cooling the analyte ions and the counter ions simultaneously in the ion trap such that a spatial distribution of the analyte ions therein is reduced; and injecting the analyte ions as an ion packet from the ion trap into the mass analyser. A mass spectrometer controller is configured to: cause an ion source to inject an amount of analyte ions of a first charge and an amount of counter ions of a second charge into an ion trap; cause the ion trap to simultaneously cool the analyte ions and the counter ions in the ion trap, thereby reducing a spatial distribution of the analyte ions therein; and cause the ion trap to inject the analyte ions into a mass analyser.
    Type: Grant
    Filed: November 7, 2018
    Date of Patent: August 4, 2020
    Assignee: Thermo Fisher Scientific (Bremen) GmbH
    Inventor: Hamish Stewart
  • Patent number: 10727039
    Abstract: A mass spectrometer comprising: a pulsed ion source for generating pulses of ions having a range of masses; a time-of-flight mass analyzer for receiving and mass analyzing the pulses of ions from the ion source; and an energy controlling electrode assembly located between the pulsed ion source and the time-of-flight mass analyzer configured to receive the pulses of ions from the pulsed ion source and apply a time-dependent potential to the ions thereby to control the energy of the ions depending on their m/z before they reach the time-of-flight mass analyzer. Mass dependent differences in average energy of ions can be reduced for injection into a time-of-flight mass analyzer, which can improve ion transmission and/or instrument resolving power.
    Type: Grant
    Filed: June 18, 2018
    Date of Patent: July 28, 2020
    Assignee: Thermo Fisher Scientific (Bremen) GmbH
    Inventors: Stewart Hamish, Dmitry Grinfeld, Alexander Makarov
  • Patent number: 10712321
    Abstract: A method to filter out pump pulses from data collected with a chromatography system is disclosed. Baseline data is collected as a pump delivers solvent to an analytical instrument, which may be the IP signal of a capillary bridge viscometer. A Fourier transform is applied to the data to generate the power spectrum of the baseline signal. Fundamental and harmonic frequencies are determined and a comb filter is constructed therefrom and applied to sample collected from all of the affected instruments. The comb filter may be correlated to the pump and flow rate and stored in data analysis software or database. Other systems using other pumps may also generate associated comb filters, and the resulting filters and the flow rates at which they were generated may be stored in a database accessible to the data analysis software.
    Type: Grant
    Filed: November 2, 2016
    Date of Patent: July 14, 2020
    Assignee: WYATT TECHNOLOGY CORPORATION
    Inventor: Steven P. Trainoff
  • Patent number: 10714323
    Abstract: The invention generally relates to zero volt mass spectrometry probes and systems. In certain embodiments, the invention provides a system including a mass spectrometry probe including a porous material, and a mass spectrometer (bench-top or miniature mass spectrometer). The system operates without an application of voltage to the probe. In certain embodiments, the probe is oriented such that a distal end faces an inlet of the mass spectrometer. In other embodiments, the distal end of the probe is 5 mm or less from an inlet of the mass spectrometer.
    Type: Grant
    Filed: February 20, 2019
    Date of Patent: July 14, 2020
    Assignee: Purdue Research Foundation
    Inventors: Robert Graham Cooks, Michael Stanley Wleklinski, Soumabha Bag, Yafeng Li
  • Patent number: 10714322
    Abstract: A sample introduction system for a spectrometer comprises a desolvation region that receives or generates sample ions from a solvent matrix and removes at least some of the solvent matrix from the sample ions. A separation chamber downstream of the desolvation region has a separation chamber inlet communicating with the desolvation region, for receiving the desolvated sample ions along with non-ionised solvent and solvent ion vapours. The separation chamber has electrodes for generating an electric field within the separation chamber, defining a first flow path for sample ions between the separation chamber inlet and a separation chamber outlet. Unwanted solvent ions and non-ionised solvent vapours are directed away from the separation chamber outlet. The sample introduction system has a reaction chamber with an inlet communicating with the separation chamber outlet, for receiving the sample ions from the separation chamber and for decomposing the received ions into smaller products.
    Type: Grant
    Filed: September 18, 2019
    Date of Patent: July 14, 2020
    Assignee: Thermo Fisher Scientific (Bremen) GmbH
    Inventors: Alexander A. Makarov, Stevan R. Horning
  • Patent number: 10705006
    Abstract: The invention relates to methods and devices for analysis of samples using laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS). The invention provides methods and devices in which individual ablation plumes are distinctively captured and transferred to the ICP, followed by analysis by mass cytometry.
    Type: Grant
    Filed: February 7, 2019
    Date of Patent: July 7, 2020
    Assignee: FLUIDIGM CANADA INC.
    Inventor: Alexandre Loboda
  • Patent number: 10707064
    Abstract: Provided is a mass spectrometer including a storage section in which an MRM measurement condition specifying an MRM transition and an execution time slot is stored for target compounds; an applied-voltage candidate value determiner for determining applied-voltage candidate values for each of the MRM transitions; a preliminary measurement number determiner for determining the number of times a preliminary measurement is performed to optimize an applied-voltage value in the plurality of MRM transitions; a unit measurement divider for dividing a plurality of unit measurements which correspond to all combinations of the MRM transitions and the applied-voltage values into the same number of groups as the number of times of the preliminary measurement, in such a manner as to minimize the number of overlaps of execution times; and a preliminary measurement execution file creator for creating a preliminary measurement execution file for each group.
    Type: Grant
    Filed: September 15, 2015
    Date of Patent: July 7, 2020
    Assignee: SHIMADZU CORPORATION
    Inventor: Masateru Oguri
  • Patent number: 10699893
    Abstract: Cylindrical ion traps (CITs) that can be used for molecular sample identification, as well as systems and methods using the same, are provided. A CIT can utilize a notched ring electrode having an inner diameter that increases as a first end of the CIT is approached from the center of the CIT or from a second end of the CIT. The first end can be the one positioned closer to the ion detector than is the second end, which can be positioned closer to the ion source than is the first end.
    Type: Grant
    Filed: December 20, 2019
    Date of Patent: June 30, 2020
    Assignee: The Florida International University Board of Trustees
    Inventors: Patrick Roman, Shekhar Bhansali
  • Patent number: 10697933
    Abstract: An ion mobility analyzing apparatus includes: a drift tube having an internal space extending in a first direction; an ion chamber having an internal space extending in the first direction and connected to the drift tube; an ion gate installed at a boundary between the drift tube and the ion chamber and kept at a ground potential; an ion source supplying ions into the ion chamber; an ion detecting electrode arranged in the drift tube on a side opposite to the ion gate; a first voltage source supplying a first high voltage to the ion chamber; a second voltage source supplying a second high voltage, having an opposite polarity to that of the first high voltage, to the ion detecting electrode; and a signal transfer unit that detects a signal from the ion detecting electrode and transmits the signal to a data processing device operating with the ground potential.
    Type: Grant
    Filed: April 4, 2019
    Date of Patent: June 30, 2020
    Assignee: SHIMADZU CORPORATION
    Inventors: Motohide Yasuno, Akiko Imazu, Yoshinori Arita
  • Patent number: 10699890
    Abstract: Methods of determining isobaric interference during mass analysis in a mass spectrometer are provided. The methods comprise comparing interference-free reaction profiles of a chemical species to reaction profiles of the same chemical species that may comprise isobaric interference, wherein a determination of a difference between the profiles is an indication of isobaric interference being present. Methods of quantifying isobaric interference are also provided, including methods of correcting isotope ratios determined in the presence of isobaric interference.
    Type: Grant
    Filed: March 5, 2019
    Date of Patent: June 30, 2020
    Assignee: Thermo Fisher Scientific (Bremen) GmbH
    Inventors: Johannes Schwieters, Henning Wehrs
  • Patent number: 10699888
    Abstract: A data independent acquisition method of mass spectrometry for analyzing a sample within a mass range of interest as it elutes from a chromatography system. The method comprises selecting precursor ions within a mass range of interest to be analyzed, performing at least one MS1 scan of the precursor ions using a Fourier Transform mass analyser and performing a set of MS2 scans by segmenting the precursor ions into a plurality of precursor mass segments, each precursor mass segment having a mass range of no greater than 5 amu, and for each precursor mass segment fragmenting the precursor ions within that precursor mass segment and performing an MS2 scan of the fragmented ions.
    Type: Grant
    Filed: May 30, 2018
    Date of Patent: June 30, 2020
    Assignee: Thermo Fisher Scientific (Bremen) GmbH
    Inventors: Anastassios Giannakopulos, Alexander Makarov, Christian Albrecht Hock, Nicolaie Eugen Damoc, Hamish Stewart
  • Patent number: 10692709
    Abstract: A method of analyzing a complex sample includes performing a sequential chromatographic-IMS-MS analysis of a sample to obtain a plurality of experimental mass spectra having isotopic clusters, wherein each spectrum of the plurality of spectra is associated with a chromatographic retention time and an ion-mobility drift time. The method also includes calculating a model isotopic cluster of a precursor or product ion associated with a candidate compound in the sample, in correspondence to the natural isotopic-abundance ratios of elements composing the compound. The method further includes comparing peaks of the model isotopic cluster to corresponding peaks of an isotopic cluster of one of the experimental mass spectra to extract one or more saturated or interfered peaks of the experimental isotopic cluster, wherein at least one of the peaks of the experimental isotopic cluster is un-saturated and un-interfered.
    Type: Grant
    Filed: October 29, 2018
    Date of Patent: June 23, 2020
    Assignee: Waters Technologies Corporation
    Inventors: Scott J. Geromanos, Marc V. Gorenstein, Daniel Golick, Steven J. Ciavarini
  • Patent number: 10692712
    Abstract: An example system includes an electron ionization ion source and a mass analyzer. The electron ion source is configured, during operation of the system, to create from sample molecules a beam of ions extending along an ion beam axis. The system also includes a collision cooling chamber comprising a gas manifold and an electric field generator. The cooling chamber defines an entrance aperture and an exit aperture on respective opposing ends of the cooling chamber, the entrance aperture of the cooling chamber being in axial alignment with the ion beam axis. The cooling chamber is configured, during operation of the system, to generate a radio frequency (RF) field within the cooling chamber using the electric field generator, and receive collision gas through the gas manifold to pressurize the cooling chamber.
    Type: Grant
    Filed: March 29, 2018
    Date of Patent: June 23, 2020
    Assignee: PerkinElmer Health Sciences, Inc.
    Inventors: David G. Welkie, Tong Chen
  • Patent number: 10692710
    Abstract: A method of manipulating ions comprises injecting ions between a first surface and a second surface positioned parallel to and spaced apart from each other and defining a central axis therebetween, wherein the first surface comprises first outer electrodes coupled to the first surface and a first inner array of electrodes coupled to the first surface and positioned between the first outer electrodes, wherein the second surface comprises second outer electrodes coupled to the second surface and a second inner array of electrodes coupled to the second surface and positioned between the second outer electrodes, and applying a frequency modulated RF voltage to at least one electrode of the first inner array of electrodes or the second inner array of electrodes to confine ions between the first surface and the second surface and to guide ions between the first surface and the second surface along the central axis.
    Type: Grant
    Filed: November 16, 2018
    Date of Patent: June 23, 2020
    Assignee: Battelle Memorial Institute
    Inventors: Aneesh Prabhakaran, Yehia M. Ibrahim, Sandilya V. B. Garimella
  • Patent number: 10684256
    Abstract: In order to make an analyzer with an ion mobility separation part have high durability and robustness, the analyzer includes an ion source, an ion mobility separation part which includes a pair of facing electrodes to which a high frequency voltage and a DC voltage are applied, and a shielding electrode which is provided between the ion source and the ion mobility separation part and to which a DC voltage is applied, wherein the shielding electrode includes an ion flow path connecting an inlet from which ions from the ion source are introduced and an outlet from which the ions are discharged thereinside, and the ion flow path is bent so that the outlet is unable to be seen from the inlet.
    Type: Grant
    Filed: February 28, 2017
    Date of Patent: June 16, 2020
    Assignee: Hitachi High-Tech Corporation
    Inventors: Hiroyuki Satake, Kazushige Nishimura, Hideki Hasegawa, Masuyuki Sugiyama
  • Patent number: 10679835
    Abstract: A surface-assisted laser desorption/ionization method according to an aspect includes: a first process of preparing a sample support (2) having a substrate (21) in which a plurality of through-holes (S) passing from one surface (21a) thereof to the other surface (21b) thereof are provided and a conductive layer (23) that covers at least the one surface (21a); a second process of placing a sample (10) on a sample stage (1) and arranging the sample support (2) on the sample (10) such that the other surface (21b) faces the sample (10); and a third process of applying a laser beam (L) to the one surface (21a) and ionizing the sample (10) moved from the other surface (21b) side to the one surface (21a) side via the through-holes (S) due to a capillary phenomenon.
    Type: Grant
    Filed: January 2, 2019
    Date of Patent: June 9, 2020
    Assignee: HAMAMATSU PHOTONICS K.K.
    Inventors: Yasuhide Naito, Masahiro Kotani, Takayuki Ohmura
  • Patent number: 10670561
    Abstract: Disclosed herein are embodiments of a system for selectively ionizing samples that may comprise a plurality of different analytes that are not normally detectable using the same ionization technique. The disclosed system comprises a unique split flow tube that can be coupled with a plurality of ionization sources to facilitate using different ionization techniques for the same sample. Also disclosed herein are embodiments of a method for determining the presence of analytes in a sample, wherein the number and type of detectable analytes that can be identified is increased and sensitivity and selectivity are not sacrificed.
    Type: Grant
    Filed: January 25, 2019
    Date of Patent: June 2, 2020
    Assignee: Battelle Memorial Institute
    Inventors: Robert Ewing, Blandina Valenzuela, Eric Freeburg
  • Patent number: 10663430
    Abstract: A system for analyzing a sample includes a source configured to generate ions from constituent components of the sample; a mobility separator configured to separate ions received from the source based on the mobility in a gas; a plurality of ion channels arranged adjacent to the plurality of exit apertures of the mobility separator such that ions from the mobility separator are directed to different channels according to their respective mobility; a mass analyzer configured to determine the mass-to-charge ratio of the ions; and a controller. The controller is configured to identify retention time windows with minimum overlap of ions with similar mobility and sets of ions within the retention time windows; adjust mobility separation parameters for specific sets of ions to optimize separation of compounds; and quantify a plurality of target analytes.
    Type: Grant
    Filed: August 8, 2018
    Date of Patent: May 26, 2020
    Assignee: Thermo Finnigan LLC
    Inventor: Mikhail V. Ugarov
  • Patent number: 10665443
    Abstract: An apparatus includes a first pair of opposing electrode arrangements that confine ions between them in a portion of a confinement volume inwardly laterally in a first confinement direction with respect to a longitudinal ion propagation direction, each opposing electrode arrangement including an arrangement of RF electrodes situated to receive an unbiased RF voltage having an alternate phase between adjacent RF electrodes of the arrangement of RF electrodes so as to provide the confining of ions between the first pair of opposing electrode arrangements, and a second pair of opposing electrode arrangements that confine the ions between the second pair in the confinement volume inwardly laterally in a second confinement direction that complements the first confinement direction, each opposing electrode arrangement of the second pair including an arrangement of RF electrodes that receive an unbiased RF voltage having an alternate phase between adjacent RF electrodes.
    Type: Grant
    Filed: February 28, 2019
    Date of Patent: May 26, 2020
    Assignee: Battelle Memorial Institute
    Inventors: Yehia M Ibrahim, Richard D. Smith
  • Patent number: 10658166
    Abstract: A method of mass or mobility spectrometry comprising obtaining one or more sample spectra for a sample. The one or more sample spectra are subjected to pre-processing and then multivariate and/or library based analysis so as to classify the sample. Before the sample spectra are acquired, a library of background spectra, each background spectrum relating to a certain class of sample material, is constructed. The background spectra in this library are used to subtract the background from a sample spectrum during the pre-processing of this sample spectrum.
    Type: Grant
    Filed: March 6, 2017
    Date of Patent: May 19, 2020
    Assignee: Micromass UK Limited
    Inventors: Keith George Richardson, Steven Derek Pringle
  • Patent number: 10658169
    Abstract: A miniature, low cost mass spectrometer capable of unit resolution over a mass range of 10 to 50 AMU. The mass spectrometer incorporates several features that enhance the performance of the design over comparable instruments. An efficient ion source enables relatively low power consumption without sacrificing measurement resolution. Variable geometry mechanical filters allow for variable resolution. An onboard ion pump removes the need for an external pumping source. A magnet and magnetic yoke produce magnetic field regions with different flux densities to run the ion pump and a magnetic sector mass analyzer. An onboard digital controller and power conversion circuit inside the vacuum chamber allows a large degree of flexibility over the operation of the mass spectrometer while eliminating the need for high-voltage electrical feedthroughs. The miniature mass spectrometer senses fractions of a percentage of inlet gas and returns mass spectra data to a computer.
    Type: Grant
    Filed: March 13, 2019
    Date of Patent: May 19, 2020
    Assignee: Massachusetts Institute of Technology
    Inventors: Ian W. Hunter, Brian D. Hemond, Harold F. Hemond
  • Patent number: 10651019
    Abstract: A system is disclosed for identifying a precursor ion of a product ion in a scanning DIA experiment. A precursor ion mass selection window is scanned across a precursor ion mass range of interest, producing a series of overlapping windows across the precursor ion mass range. Each overlapping window is fragmented and mass analyzed, producing a plurality of product ion spectra for the mass range. A product ion is selected from the spectra. Intensities for the selected product ion are retrieved for at least one scan across the mass range producing a trace of intensities versus precursor ion m/z. A matrix multiplication equation is created that describes how one or more precursor ions correspond to the trace for the selected product ion. The matrix multiplication equation is solved for one or more precursor ions corresponding to the selected product ion using a numerical method.
    Type: Grant
    Filed: July 19, 2017
    Date of Patent: May 12, 2020
    Assignee: DH Technologies Development Pte. Ltd.
    Inventors: Gordana Ivosev, Nic G. Bloomfield, Michael Murphy, Stephen A. Tate