Ionic Separation Or Analysis Patents (Class 250/281)
  • Patent number: 10438781
    Abstract: A columnar rod reference member made of a material whose coefficient of thermal expansion is different from a flight tube is placed in contact with the tube. One end of the tube and o the reference member are fixed to each other with a fixture part. A distance measurement sensor measures the difference in length between the tube and the reference member whose lengths fluctuate due to a change in temperature. A displacement of the difference in length, as expressed by a proportion, is larger than that of the length of the flight tube. The difference in length is far smaller than the length of the flight tube. This improves detection of the displacement due to thermal expansion with a strain gauge or sensor. The m/z values in mass spectrum data are corrected based on the measured values of the displacement, whereby a highly accurate mass discrepancy correction is achieved.
    Type: Grant
    Filed: October 16, 2015
    Date of Patent: October 8, 2019
    Assignee: SHIMADZU CORPORATION
    Inventor: Shinichi Yamaguchi
  • Patent number: 10438769
    Abstract: A scanning electron microscopy (SEM) system includes a plurality of electron beam sources configured to generate a primary electron beam. The SEM system includes an electron-optical column array with a plurality of electron-optical columns. An electron-optical column includes a plurality of electron-optical elements. The plurality of electron-optical elements includes a deflector layer configured to be driven via a common controller shared by at least some of the plurality of electron-optical columns and includes a trim deflector layer configured to be driven by an individual controller. The plurality of electron-optical elements is arranged to form an electron beam channel configured to direct the primary electron beam to a sample secured on a stage, which emits an electron beam in response to the primary electron beam. The electron-optical column includes an electron detector. The electron beam channel is configured to direct the electron beam to the electron detector.
    Type: Grant
    Filed: May 2, 2018
    Date of Patent: October 8, 2019
    Assignee: KLA-Tencor Corporation
    Inventors: Alex Lipkind, Alon Rosenthal, Frank Chilese, John Gerling, Lawrence Muray, Robert Haynes
  • Patent number: 10431445
    Abstract: To reduce contamination of the apparatus with an additive and to quickly switch spraying and stopping of the additive, provided is an ion analyzer including: an ion source for ionizing a measurement target substance, a spray unit for atomizing and spraying toward the measurement target substance a liquid containing an additive that reacts with the measurement target substance; a separation analysis unit for separately analyzing an ion generated by a reaction between the measurement target substance and the additive; a detector for detecting the ion that has been separately analyzed by the separation analysis unit; and a control unit for lowering a flow rate of the additive supplied to the spray unit during a time when the additive is not necessary.
    Type: Grant
    Filed: October 9, 2015
    Date of Patent: October 1, 2019
    Assignee: HITACHI HIGH-TECHNOLOGIES CORPORATION
    Inventors: Kazushige Nishimura, Hiroyuki Satake, Masuyuki Sugiyama, Hideki Hasegawa, Tomoyuki Sakai
  • Patent number: 10431443
    Abstract: The present invention is concerned with a device for charged particle transportation and manipulation. Embodiments provide a capability of combining positively and negatively charged particles in a single transported packet. Embodiments contain an aggregate of electrodes arranged to form a channel for transportation of charged particles, as well as a source of power supply that provides supply voltage to be applied to the electrodes, the voltage to ensure creation, inside the said channel, of a non-uniform high-frequency electric field, the pseudopotential of which field has one or more local extrema along the length of the channel used for charged particle transportation, at least, within a certain interval of time, whereas, at least one of the said extrema of the pseudopotential is transposed with time, at least within a certain interval of time, at least within a part of the length of the channel used for charged particle transportation.
    Type: Grant
    Filed: December 12, 2018
    Date of Patent: October 1, 2019
    Assignee: Shimadzu Research Laboratory (Europe) Ltd.
    Inventors: Alexander Berdnikov, Alina Andreyeva, Roger Giles
  • Patent number: 10429396
    Abstract: Methods are provided for detecting the amount of one or more CAH panel analytes (i.e., pregnenolone, 17-OH pregnenolone, progesterone, 17-OH progesterone, dehydroepiandrosterone (DHEA), androstenedione, testosterone, deoxycorticosterone, 11-deoxycortisol, and cortisol) in a sample by mass spectrometry. The methods generally involve ionizing one or more CAH panel analytes in a sample and quantifying the generated ions to determine the amount of one or more CAH panel analytes in the sample. In methods where amounts of multiple CAH panel analytes are detected, the amounts of multiple analytes are detected in the same sample injection.
    Type: Grant
    Filed: March 19, 2018
    Date of Patent: October 1, 2019
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Amit Ghoshal, Nigel J. Clarke, Mildred M. Goldman
  • Patent number: 10424471
    Abstract: An apparatus includes a flexible ion conduit extending between an input end situated to receive ions and an output end to define an ion passageway having an axis, the flexible ion conduit including an inner conduit portion having an inner surface facing the interior ion passageway and having a plurality of RF electrodes adjacently situated to receive RF voltages that are out of phase with respect to each other to direct the received ions away from the inner surface and into the ion passageway.
    Type: Grant
    Filed: June 26, 2018
    Date of Patent: September 24, 2019
    Assignee: Battelle Memorial Institute
    Inventors: Richard D. Smith, Sandilya V. B. Garimella, Yehia M. Ibrahim
  • Patent number: 10424470
    Abstract: An apparatus for mass spectrometry comprises a portion generator (10) for creating localized analyte portions in synchronization with trigger pulses, a transfer system (20) coupled to the portion generator (10) for transporting the localized analyte portions, a plasma ionizer unit (30) coupled to the transfer system (20) for atomizing, vaporizing and ionizing received analyte portions with plasma, a mass analyzer (41) coupled to the plasma ionizer unit (30) for analyzing received analyte portions, the mass analyzer (41) comprising at least one detector, and a data acquisition electronics (50) connected to the at least one detector for acquiring signals (43) generated by the at least one detector. The apparatus further includes a signal delay device (60) for receiving the trigger pulses (11) and delivering delayed signals (61) corresponding to the trigger pulses to account for a delay experienced by the particles to be analyzed between portion generation and detection.
    Type: Grant
    Filed: March 18, 2016
    Date of Patent: September 24, 2019
    Assignee: TOFWERK AG
    Inventors: Christian Tanner, Martin Tanner, Marc Gonin
  • Patent number: 10416131
    Abstract: For improving sensitivity, dynamic range, and specificity of GC-MS analysis there are disclosed embodiments of novel apparatuses based on improved characteristics of semi-open source with electron impact ionization, providing much higher brightness compared to known open EI sources. In an implementation, the source becomes compatible with multi-reflecting TOF analyzers for higher resolution analysis for improving detection limit. With improved schemes of spatial and temporal refocusing there are proposed various tandem TOF-TOF spectrometers with PSD, CID, and SID fragmentation and using either singly reflecting TOF or MR-TOF analyzers.
    Type: Grant
    Filed: March 31, 2015
    Date of Patent: September 17, 2019
    Assignee: LECO Corporation
    Inventor: Anatoly N. Verenchikov
  • Patent number: 10408814
    Abstract: Disclosed herein is a method of generating a high resolution image of a cellular sample, the method including i) labeling a cellular sample with at least one mass tag, thereby producing a labeled sample in which a biological feature of interest is associated with the at least one mass tag, ii) scanning the sample with a continuous or near-continuous primary ion beam to generate sputtered secondary ions and sputtered neutral species, iii) photoionizing the sputtered neutrals to generate ionized neutral species, wherein the sputtered neutrals are photoionized at a site that is proximal to their source on the sample, iv) detecting the ionized neutral species by mass spectrometry, thereby obtaining spatially addressed measurements of the abundance of the at least one mass tag across an area of the sample, and v) producing an image of the sample using the measurements. A system for performing the method is also provided.
    Type: Grant
    Filed: September 19, 2017
    Date of Patent: September 10, 2019
    Assignee: The Board of Trustees ofthe Leland Stanford Junior University
    Inventor: Robert M. Angelo
  • Patent number: 10401342
    Abstract: Disclosed herein are an evolved gas analyzer and a method for analyzing evolved gas, the apparatus cooling a sample holder in a short time without using excessive cooling performance and without providing the entire apparatus in an excessively large size, thereby enhancing analysis work efficiency. The apparatus 200 includes: a sample holder 20 holding a sample S; a heating unit 10 receiving the sample holder therein, and evolving a gas component G by heating the sample; a detecting means 110 detecting the gas component; a sample holder supporting unit 204L movably supporting the sample holder to move the sample holder to predetermined outer and inner positions of the heating unit; and a cooling unit 30 provided at an outside of the heating unit, and cooling the sample holder by being in direct or indirect contact with the sample holder, when the sample holder is moved to a discharging position.
    Type: Grant
    Filed: November 19, 2016
    Date of Patent: September 3, 2019
    Assignee: HITACHI HIGH-TECH SCIENCE CORPORATION
    Inventors: Hideyuki Akiyama, Kentaro Yamada, Toshitada Takeuchi
  • Patent number: 10403485
    Abstract: A method of encoding a parent or precursor ion beam to aid product ion assignment is disclosed. According to an embodiment the energy of parent ions entering a collision cell is progressively increased. Different species of parent ions fragment at different collision energies. Fragment ion intensity profiles are matched with parent ion intensity profiles to correlate fragment ions with corresponding parent ions.
    Type: Grant
    Filed: September 17, 2012
    Date of Patent: September 3, 2019
    Assignee: Micromass UK Limited
    Inventors: Kevin Giles, Martin Raymond Green, Keith Richardson, Jason Lee Wildgoose
  • Patent number: 10403489
    Abstract: Systems and approaches for semiconductor metrology and surface analysis using Secondary Ion Mass Spectrometry (SIMS) are disclosed. In an example, a secondary ion mass, spectrometry (SIMS) system includes a sample stage. A primary ion beam is directed to the sample stage. An extraction lens is directed at the sample stage. The extraction lens is configured to provide a low extraction field for secondary ions emitted from a sample on the sample stage. A magnetic sector spectrograph is coupled to the extraction lens along an optical path of the SIMS system. The magnetic sector spectrograph includes an electrostatic analyzer (ESA) coupled to a magnetic sector analyzer (MSA).
    Type: Grant
    Filed: July 18, 2018
    Date of Patent: September 3, 2019
    Assignee: NOVA MEASURING INSTRUMENTS INC.
    Inventors: David A. Reed, Bruno W. Schueler, Bruce H. Newcome, Rodney Smedt, Chris Bevis
  • Patent number: 10395906
    Abstract: A columnar rod reference member made of a material whose coefficient of thermal expansion is different from a flight tube is placed in contact with the tube. One end of the tube and o the reference member are fixed to each other with a fixture part. A distance measurement sensor measures the difference in length between the tube and the reference member whose lengths fluctuate due to a change in temperature. A displacement of the difference in length, as expressed by a proportion, is larger than that of the length of the flight tube. The difference in length is far smaller than the length of the flight tube. This improves detection of the displacement due to thermal expansion with a strain gauge or sensor. The m/z values in mass spectrum data are corrected based on the measured values of the displacement, whereby a highly accurate mass discrepancy correction is achieved.
    Type: Grant
    Filed: October 16, 2015
    Date of Patent: August 27, 2019
    Assignee: SHIMADZU CORPORATION
    Inventor: Shinichi Yamaguchi
  • Patent number: 10388500
    Abstract: A mass spectrometer is disclosed comprising a mass selective ion trap and a quadrupole rod set mass filter arranged downstream of the mass selective ion trap. Ions are mass selectively ejected from the ion trap in a substantially synchronized manner with the scanning of the mass filter in order to increase the duty cycle of the mass filter.
    Type: Grant
    Filed: June 12, 2017
    Date of Patent: August 20, 2019
    Assignee: Micromass UK Limited
    Inventor: John Hoyes
  • Patent number: 10386372
    Abstract: The invention pertains to materials and methods for identifying and/or isolating isomers, particularly, of biomolecules, such as polypeptides and proteins. The methods of identifying and/or isolating isomers of a molecule according to the invention comprise subjecting a sample to ionization prior to IMS followed by MS. In some embodiments, the sample is subjected to metallization during the ionization step.
    Type: Grant
    Filed: February 9, 2018
    Date of Patent: August 20, 2019
    Assignee: The Florida International University Board of Trustees
    Inventors: Francisco Fernandez Lima, Kevin Jeanne Dit Fouque
  • Patent number: 10388498
    Abstract: The present invention relates to a gas inlet system for an analytical apparatus. The gas inlet system comprises switchable flow restrictions for regulating gas flow rate. The invention also provides a system for calibrating gas flow rate in gas inlet systems, the system comprising a calibration line that comprises a gas flow meter, and that is arranged downstream of gas flow controllers in the gas inlet system. Methods of adjusting gas flow rates and methods of calibrating gas flow rates are also provided.
    Type: Grant
    Filed: December 11, 2017
    Date of Patent: August 20, 2019
    Assignee: Thermo Fisher Scientific (Bremen) GmbH
    Inventor: Thorben Schuethe
  • Patent number: 10385379
    Abstract: An apparatus that identifies the type of a test cell based on a result obtained by performing mass spectrometry on the test cell includes a higher-level database, which contains mass lists that each list ion mass values of constituent components of a known cell, and a lower-level database, which contains partial mass lists that each list only strain-specific ion mass values out of the ion mass values. The higher-level database is first searched for a test mass list which is created from the result of the mass spectrometry performed on the test cell, and based on a result of the search, an organism species to be searched in the following search operation is determined. Mass values common to the organism species are subsequently deleted from the mass list for the test cell, and the mass list having undergone the deletion operation is used to search the lower-level database.
    Type: Grant
    Filed: October 17, 2012
    Date of Patent: August 20, 2019
    Assignee: SHIMADZU CORPORATION
    Inventors: Noriyuki Ojima, Koretsugu Ogata, Keisuke Shima, Hiroto Tamura, Akifumi Hosoda, Yudai Hotta
  • Patent number: 10388507
    Abstract: An acceleration voltage generator (7) generates a high-voltage pulse to be applied to a push-out electrode (11), by operating a switch section (74) to turn on and off a high direct-current voltage generated by a high-voltage power supply (75). A drive pulse signal is supplied from a controller (6) to the switch section (74) through a primary-side drive section (71), transformer (72), and secondary-side drive section (73). The measurement period of a repeated measurement is changed according to a target m/z range. A primary-voltage controller (61) controls a primary-side power supply (76) to change a primary-side voltage according to the measurement period, thereby adjusting the voltage to be applied between the two ends of a primary winding of the transformer (72) by the primary-side drive section (71). The pulse signal fed to the switch section (74) overshoots due to LC resonance.
    Type: Grant
    Filed: January 12, 2016
    Date of Patent: August 20, 2019
    Assignee: SHIMADZU CORPORATION
    Inventor: Shiro Mizutani
  • Patent number: 10388501
    Abstract: An ion transfer device for transferring ions from a first chamber to a second, reduced-pressure chamber includes a tube and a bore selector. The tube includes a plurality of tube bores. The bore selector is positioned at an inlet end of the tube and includes an inlet port. The tube is movable relative to the bore selector, and/or the bore selector is movable relative to the tube, to align the inlet port with a selected one of the tube bores while blocking the other tube bores. Alignment of the inlet port with the selected tube bore defines an ion transfer path from the first chamber, through the selected tube bore, and to the second chamber. The ion transfer device may be utilized, for example, in an atmospheric-pressure interface of a mass spectrometer.
    Type: Grant
    Filed: April 23, 2018
    Date of Patent: August 20, 2019
    Assignee: Agilent Technologies, Inc.
    Inventors: Maozi Liu, Nigel P. Gore
  • Patent number: 10381208
    Abstract: A method of processing an image charge/current signal representative of trapped ions undergoing oscillatory motion. The method includes: identifying a plurality of fundamental frequencies potentially present in the image charge/current signal based on an analysis of peaks in a frequency spectrum corresponding to the image charge/current signal in the frequency domain, wherein each candidate fundamental frequency falls in a frequency range of interest; deriving a basis signal for each candidate fundamental frequency using a calibration signal; and estimating relative abundances of ions corresponding to the candidate fundamental frequencies by mapping the basis signals to the image charge/current signal. At least one candidate fundamental frequency is calculated using a frequency associated with a peak that falls outside the frequency range of interest and that has been determined as representing a second or higher order harmonic of the candidate fundamental frequency.
    Type: Grant
    Filed: March 22, 2017
    Date of Patent: August 13, 2019
    Assignee: SHIMADZU CORPORATION
    Inventors: Sergey Smirnov, Li Ding, Aleksandr Rusinov
  • Patent number: 10381207
    Abstract: For peak A detected on a chromatogram created based on data obtained by a product ion scan measurement of one characteristic ion species originating from a target compound, a mass spectrum is extracted, and this mass spectrum is subjected to a database search to extract candidates of the compound as a primary search result. Subsequently, for peak B detected on a chromatogram created based on data obtained by a product ion scan measurement of another characteristic ion species originating from the same target compound, a mass spectrum is extracted, and this mass spectrum is subjected to a database search, with the search range limited to the candidates extracted in the search result based on peak A, to further reduce the number of candidates. The result which has been narrowed in this manner is displayed, whereby the amount of labor for the compound identification by analysis operators is reduced.
    Type: Grant
    Filed: September 4, 2013
    Date of Patent: August 13, 2019
    Assignee: SHIMADZU CORPORATION
    Inventor: Yuki Sakamoto
  • Patent number: 10381209
    Abstract: The invention generally relates to probes, systems, cartridges, and methods of use thereof. In certain embodiments, the invention provides a probe including a porous material and a hollow member coupled to a distal portion of the porous material.
    Type: Grant
    Filed: February 8, 2016
    Date of Patent: August 13, 2019
    Assignee: Purdue Research Foundation
    Inventors: Zheng Ouyang, Yue Ren, Xiao Wang
  • Patent number: 10371665
    Abstract: A method of mass spectrometry is disclosed comprising separating a first population of ions according to their ion mobility and selectively attenuating ions in the first population of ions in one or more ion mobility and/or drift time ranges so as to form a second population of ions. The step of selectively attenuating ions comprises applying a varying, increasing or decreasing attenuation factor to ions in different ion mobility and/or drift time ranges. The method further comprises separating the second population of ions according to their ion mobility.
    Type: Grant
    Filed: June 5, 2015
    Date of Patent: August 6, 2019
    Assignee: MICROMASS UK LIMITED
    Inventors: Martin Raymond Green, Jason Lee Wildgoose
  • Patent number: 10366872
    Abstract: A quadrupole mass filter and method for operating the filter are described. Sample ions, each having a mass-to-charge ratio, are passed to a quadrupole at least one AC voltage is applied thereto to separate the ions by incrementally varying a frequency of the at least one AC voltage within a first range of frequencies and, for each of at least some of the incremental frequencies in the first range of frequencies, incrementally varying an amplitude of the at least one AC voltage within a range of amplitudes, wherein each incremental frequency and incremental amplitude pair of the at least one AC voltage creates a different band pass filter in the quadrupole through which produced ions having a different corresponding mass-to-charge ratio pass to a detector.
    Type: Grant
    Filed: January 31, 2019
    Date of Patent: July 30, 2019
    Assignee: The Trustees of Indiana University
    Inventors: Martin F. Jarrold, Deven L. Shinholt, Staci N. Anthony, Andrew W. Alexander
  • Patent number: 10366873
    Abstract: Described herein are cryogenic linear ion traps and uses thereof.
    Type: Grant
    Filed: May 3, 2018
    Date of Patent: July 30, 2019
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Nicolas Camille Polfer, Todd A. Prox, Larry F. Tesler, Matthew Bell, Adam P. Cismesia
  • Patent number: 10361074
    Abstract: An ionization chamber. The ionization chamber includes a vessel, an ionization source, an ion gate, and a mid-ring electrode. The vessel defines an ionization region. The vessel includes a first end axially disposed opposite a second end. The ionization source is located at the first end and generates ions. The ion gate is located at the second end of the vessel. The mid-ring electrode is located between the ionization source and the ion gate. During an ion compression stage, the ionization source is charged to a first ionization source potential, the ion gate is charged to a first ion gate potential, and the mid-ring electrode is charged to a first mid-ring potential that is less than the first ionization source potential and the first ion gate potential. The first mid-ring potential is configured to generate a potential well proximate the mid-ring electrode. The ions collect at the potential well.
    Type: Grant
    Filed: November 21, 2017
    Date of Patent: July 23, 2019
    Assignee: Rapiscan Systems, Inc.
    Inventors: Hanh T. Lai, Karl Goedecke
  • Patent number: 10361075
    Abstract: A system and a process for measuring, by glow discharge spectrometry, the elemental and/or molecular chemical composition of an organic solid sample (10). The sample (10) is positioned so as to seal a glow discharge plasma reactor (2), a gaseous mixture including at least one inert gas and gaseous oxygen is injected into the reactor (2), the concentration of gaseous oxygen being between 0.1% and 15% by weight of the gaseous mixture, an electric discharge of radiofrequency type is applied to the electrodes of the plasma reactor (2) in order to generate a glow discharge plasma, and the solid sample (10) is exposed to the plasma so as to etch an erosion crater in the solid sample (10); at least one signal representative of an ionized species of negative charge is selected and measured using a mass spectrometer (4).
    Type: Grant
    Filed: March 27, 2015
    Date of Patent: July 23, 2019
    Assignee: HORIBA JOBIN YVON SAS
    Inventors: Patrick Chapon, Agnes Tempez, Sebastien Legendre
  • Patent number: 10359398
    Abstract: The present invention relates to a method for determining in an expedient manner and with minimal sample consumption the structure of an unknown carbohydrate by using ion mobility-mass spectrometry (IM-MS) in negative ionization mode and fragmentation and a database containing structures of carbohydrates and/or of the fragments of the negative ions of carbohydrates, and for each of the structures of the target carbohydrates the collision cross section value and the mass-to-charge ratio value of the negative ion thereof, and for each of the structures of the fragments of the negative ions of the target carbohydrates the collision cross section value and the mass-to-charge ratio value of the fragment of the negative ion of the target carbohydrate.
    Type: Grant
    Filed: September 3, 2015
    Date of Patent: July 23, 2019
    Assignees: Max-Planck-Gesellschaft zur Forderung der Wissenschaften e.V., Freie Universitat Berlin
    Inventors: Johanna Hofmann, Heung Sik Hahm, Peter Seeberger, Kevin Pagel
  • Patent number: 10354847
    Abstract: A miniature mass spectrometer is disclosed comprising an atmospheric pressure ionization source 701, a first vacuum chamber having an atmospheric pressure sampling orifice or capillary, a second vacuum chamber located downstream of the first vacuum chamber and a third vacuum chamber located downstream of the second vacuum chamber. A first vacuum pump 707 is arranged and adapted to pump the first vacuum chamber, wherein the first vacuum pump 707 is arranged and adapted to maintain the first vacuum chamber at a pressure <10 mbar. A first RF ion guide 702 is located within the first vacuum chamber. An ion detector 705 is located in the third vacuum chamber. The ion path length from the atmospheric pressure sampling orifice or capillary to an ion detecting surface of the ion detector 705 is ?400 mm.
    Type: Grant
    Filed: June 27, 2018
    Date of Patent: July 16, 2019
    Assignee: MICROMASS UK LIMIED
    Inventors: David Gordon, Daniel James Kenny
  • Patent number: 10345264
    Abstract: The present disclosure relates to an ion exchange process, as well as a process and system for detecting nitrates, which employ a class of dopants comprising at least two functional groups capable of simultaneous convergent hydrogen bonding with a nitrate ion.
    Type: Grant
    Filed: April 28, 2016
    Date of Patent: July 9, 2019
    Assignee: SMITHS DETECTION MONTREAL INC.
    Inventors: Jan Hendrikse, Vladimir Romanov, Udo Verkerk, Alan Hopkinson
  • Patent number: 10345281
    Abstract: Volatilization reagents are disclosed for improved detection of inorganic oxidizers such as chlorates and perchlorates by mass spectrometry. Thermal desorption methods are also disclosed in which the reagent transfers a proton to the anion (i.e., chlorate, perchlorate, etc.) of an inorganic salt analyte, forming an acid (i.e., chloric acid, perchloric acid) that is more easily vaporized and, hence, more easily detected. The reagents can include acidic salts or cation-donators, more generally. The class of reagents including polymeric acids, polymeric organic acids and polymeric sulfonic acids. Hydrated reagents or other reagents that can release water can also be employed as co-reagents. Further, these reagents can be embedded in a swipe or other substrate, delivered as a liquid infused via nebulizer, or otherwise introduced to a sample to be tested.
    Type: Grant
    Filed: April 6, 2015
    Date of Patent: July 9, 2019
    Assignee: Massachusetts Institute of Technology
    Inventors: Jude A. Kelley, Roderick Russell Kunz, Alla Ostrinskaya, Richard Paul Kingsborough
  • Patent number: 10347477
    Abstract: A method of quantitative mass analysis of precursor ion species of different mass-to-charge (m/z) ratios from the same or common ion injection event is disclosed. A plurality of precursor ion species with different respective m/z ratios are introduced into an ion trap mass analyzer at the same time. The precursor ion species are isolated. A first subset of the isolated precursor ions, which are multiply charged and have a first m/z ratio range, is fragmented and scanned by dividing the scan into at least two separate scan windows. A first mass spectrum is generated for the fragment ions of the first subset of precursor ions. A second subset of the isolated precursor ions having a second m/z ratio is fragmented and scanned, and a second mass spectrum is generated for the fragment ions of the second subset of precursor ions.
    Type: Grant
    Filed: March 5, 2018
    Date of Patent: July 9, 2019
    Assignee: THERMO FINNIGAN LLC
    Inventors: Linfan Li, Jae C. Schwartz
  • Patent number: 10345261
    Abstract: Methods and systems are provided herein for varying the CoV about a nominal CoV-apex while monitoring the ion of interest corresponding to the nominal CoV-apex as it is transmitted by a DMS. In various aspects, the CoV can be swept or stepped across a series of values during the injection of ions into the DMS such that a composite spectra of the ion of interest transmitted by the DMS (or its product ions following one or more stages of fragmentation) can be generated so as to include the transmission of the particular ion at a CoV with optimum sensitivity (i.e., if distinct from the CoV-apex), thereby improving the robustness, accuracy, and/or selectivity during experimental conditions relative to known DMS techniques, which typically used a fixed CoV value for each ion of interest.
    Type: Grant
    Filed: December 16, 2015
    Date of Patent: July 9, 2019
    Assignee: DH Technologies Development Pte. Ltd.
    Inventors: John Lawrence Campbell, Yves Le Blanc
  • Patent number: 10347480
    Abstract: The invention relates to a method for evaluating a quality of preparations of analytical tissue sections for mass spectrometric imaging using a reference sample to be processed and measured alongside the analytical tissue sections, and a kit-of-parts for a mass spectrometric imaging experiment including such reference sample.
    Type: Grant
    Filed: September 25, 2017
    Date of Patent: July 9, 2019
    Inventor: Sören-Oliver Deininger
  • Patent number: 10345262
    Abstract: A method of analyzing a sample by high-field asymmetric waveform ion mobility-mass spectrometry (FAIMS-MS) is disclosed. An ion beam containing ions of a plurality N of isomers is directed into a FAIMS device. The compensation voltage (CV) at which the FAIMS device is operated is varied among a plurality M of values. For each of the M CV values, an intensity of the ion beam transmitted by the FAIMS device, or product ions derived therefrom, is measured at a mass-to charge ratio corresponding to the plurality N of isomers. The intensities of each of the plurality N of isomers is determined using a set of linear equations, relating the weighted measured intensity values at each value M of the CV and the intensities of each of the N isomers when the FAIMS device is in a non-separation condition.
    Type: Grant
    Filed: December 15, 2017
    Date of Patent: July 9, 2019
    Assignee: THERMO FINNIGAN LLC
    Inventors: Bennett S. Kalafut, Rae Ana Snyder
  • Patent number: 10338028
    Abstract: An ion mobility separation device includes: an ion source that generates an ion; a pair of flat-plate electrodes having an introduction opening and a discharge opening for the ion generated by the ion source; a pump for causing the ion introduced via the introduction opening of the pair of flat-plate electrodes to travel toward the discharge opening; a voltage control unit that applies an asymmetric time-varying voltage and a direct-current voltage to the pair of flat-plate electrodes; a plurality of detectors disposed in a direction orthogonal to both an ion travel direction due to the pump and an applied direction of the asymmetric time-varying voltage; and a signal processing unit that processes a signal detected by the plurality of detectors.
    Type: Grant
    Filed: July 19, 2013
    Date of Patent: July 2, 2019
    Assignee: Hitachi, Ltd.
    Inventors: Yuichiro Hashimoto, Hideki Hasegawa, Masao Suga, Hiroyuki Satake
  • Patent number: 10335123
    Abstract: The present invention provides for a system, method, and device for analyzing, localizing and/or identifying tissue types. The method includes analyzing, localizing and/or identifying one or more tissue samples, characterized in that the method comprises: (a) generating gaseous tissue particles from a site in the one or more tissue samples, (b) transporting the gaseous tissue particles from the site to an analyzer, (c) using the analyzer for generating tissue-related data based on the gaseous tissue particles, and (d) analyzing, localizing and/or identifying the one or more tissue samples based on the tissue-related data. The invention can either be used in close conjunction with a surgical procedure, when one or more surgical tools are an integrated part of ionization, or as a separate mass spectrometric probe for the analysis of one or more tissue parts.
    Type: Grant
    Filed: April 1, 2015
    Date of Patent: July 2, 2019
    Assignee: MICROMASS UK LIMITED
    Inventor: Zoltan Takats
  • Patent number: 10332733
    Abstract: A precursor ion selected by a quadrupole mass filter is fragmented by imparting a predetermined amount of collision energy (CE) to the ion. Among the thereby generated product ions, only the ions included within a predetermined m/z range are stored in an ion trap. The ions are subsequently separated and detected by a TOF. For one precursor ion originating from a target compound, a mass spectrometric analysis is performed for each combination of a plurality of the set CE values and subdivided m/z ranges to obtain spectrum data. A spectrum data accumulator accumulates the spectrum data obtained by the mass spectrometric analysis under different combinations of (CE value, m/z range). Based on the accumulated spectrum data, a mass spectrum creator creates a single product-ion spectrum corresponding to the target compound.
    Type: Grant
    Filed: July 28, 2015
    Date of Patent: June 25, 2019
    Assignee: SHIMADZU CORPORATION
    Inventor: Tohru Shiohama
  • Patent number: 10332723
    Abstract: Apparatus include a plurality of electrode arrangements spaced apart from each other opposite an ion propagation axis and defining an ion transfer channel that extends along the ion propagation axis that tapers between an input end that is situated to receive ions and an output end that is situated to couple the received ions to an input end of an ion guide. Methods include positioning a plurality of electrode arrangements at oblique angles opposite an ion propagation axis so as to form a ion transfer channel that tapers between an input end and an output end, and coupling the output end of the ion transfer channel to an input end of an ion optical element so as to direct ions in the ion transfer channel into the ion optical element. Related systems are also disclosed.
    Type: Grant
    Filed: December 20, 2017
    Date of Patent: June 25, 2019
    Assignee: Battelle Memorial Institute
    Inventors: Yehia M. Ibrahim, Richard D. Smith
  • Patent number: 10324071
    Abstract: A chromatograph mass spectrometer including: an MSn-1 analysis setter for setting an analysis execution period for performing an MSn-1 analysis, an execution time for the analysis and a loop time; an analysis period divider for dividing the analysis period into segments according to a change in number or analysis condition of MSn-1 analyses to be performed within the same time window; an MSn analysis setter for performing MSn-1 analysis to obtain mass spectrum data and for scheduling MSn analysis, an ion corresponding to a peak satisfying a set condition being designated as a precursor ion; an MSn analysis execution time allotter for allotting, in each segment, a time period for execution of the MSn analysis, the time period being calculated by subtracting an event execution time from the loop time; and an analysis executer for repeatedly performing MSn-1 analysis and MSn analysis in each segment.
    Type: Grant
    Filed: November 17, 2014
    Date of Patent: June 18, 2019
    Assignee: SHIMADZU CORPORATION
    Inventors: Hideki Yamamoto, Yuko Kobayashi
  • Patent number: 10325767
    Abstract: A FAIMS device interfaces between an ionization source and a mass spectrometer. The FAIMS device includes inner and outer electrodes having radially opposed surfaces, which define there between a gap through which ions are transported. A waveform generator is configured to apply a selected one of two distinct periodic waveforms to the electrodes, consisting of: a first waveform characterized by equal high and low amplitudes and periods and a second waveform including a bi-sinusoidal waveform superimposed with a DC compensation voltage. The device is configured to toggle between a transmission mode of operation in which ions are passed through the device with no spatial separation when the first waveform is applied to the inner and/or outer electrodes and a separation mode of operation in which spatial separation of the ions occurs in the gap when the bi-sinusoidal waveform and DC voltage are applied to the inner and/or outer electrodes.
    Type: Grant
    Filed: March 9, 2018
    Date of Patent: June 18, 2019
    Assignee: THERMO FINNIGAN LLC
    Inventors: Satendra Prasad, Michael W. Belford, Jean-Jacques Dunyach
  • Patent number: 10327319
    Abstract: Devices, systems and methods using counterflow sample introduction are described. In certain examples, the devices, systems and methods may be configured to introduce a fluid flow comprising a sample into a torch comprising a plasma in a direction that opposes the flow of a gas used to sustain the plasma. Optical emission devices, optical absorption devices and mass spectrometers using the counterflow sample introduction are also described.
    Type: Grant
    Filed: May 24, 2017
    Date of Patent: June 18, 2019
    Assignee: PerkinElmer Health Sciences, Inc.
    Inventor: Peter Morrisroe
  • Patent number: 10325764
    Abstract: A method of automatically performing a routine to check the operational state of a mass spectrometer is disclosed wherein the method is performed automatically as a start-up routine upon switching ON the mass spectrometer. The method comprises automatically generating a vacuum within one or more vacuum chambers of a mass spectrometer and automatically generating first ions using an internal ion source, wherein the internal ion source is located within a vacuum chamber of the mass spectrometer or is located within a chamber downstream from an atmospheric pressure interface, and detecting at least some of the first ions or second ions derived from the first ions. The method further comprises automatically determining whether or not the mass spectrometer is in a correct operational state.
    Type: Grant
    Filed: December 11, 2017
    Date of Patent: June 18, 2019
    Assignee: MICROMASS UK LIMITED
    Inventors: David Gordon, Daniel James Kenny, Howard Read, Kate Whyatt
  • Patent number: 10324030
    Abstract: Methods, devices, and systems are provided for analyzing the moisture content in natural gas. In one embodiment, a portable moisture analyzer system is provided and can include a moisture analyzer and a housing. The moisture analyzer can include a tunable diode laser absorption spectrometer (TDLAS) and a natural gas sample conditioning system. The TDLAS can be configured to detect water vapor content within a natural gas sample. The sample conditioning system can be in fluid communication with the TDLAS and can be configured to condition at least one of temperature, flow rate, and pressure of a natural gas sample. The housing can be configured to receive the moisture analyzer therein and to protect the moisture analyzer from vibration and/or shock.
    Type: Grant
    Filed: December 26, 2017
    Date of Patent: June 18, 2019
    Assignee: GE Infrastructure Sensing, LLC
    Inventors: John Sanroma, John Poole, Aniruddha Sudheer Weling, Gene Berkowitz
  • Patent number: 10325766
    Abstract: A method of mass spectrometry or ion mobility spectrometry is disclosed. The method comprises: providing a plurality of species of ions; analyzing the ions during a plurality of sequential acquisition periods so as to obtain spectral data relating to the ions; varying the value of an operational parameter of the spectrometer such that it has different values during the different acquisition periods, wherein the spectral data obtained for a given ion varies depending on the value of the operational parameter; storing the spectral data obtained during the different acquisition periods separately; selecting a target ion; and then interrogating the spectral data so as to identify a set of first acquisition periods that include data corresponding to said target ion. Selecting spectral data from only a subset of the first acquisition periods allows the selection of the optimal spectral data for the target ion, while discarding less optimal data.
    Type: Grant
    Filed: April 1, 2015
    Date of Patent: June 18, 2019
    Assignee: MICROMASS UK LIMITED
    Inventors: Richard Moulds, Keith Richardson, Jason Lee Wildgoose, Martin Raymond Green
  • Patent number: 10317380
    Abstract: A chromatograph mass spectrometer has a function that: based on a compound table in which an elution time range and a measurement ion is described for respective compounds, divides an overall measurement time into multiple segments and assigns one or more compounds to each segment; determines an event time for each compound by dividing a previously given measurement loop time in accordance with a number of compounds belonging to the respective segments; and determines a dwell time, which is a data collection time for each ion, based on the event time and the number of ions to be measured for each compound; the chromatograph mass spectrometer allowing an analysis operator to designate whether or not to perform a high-sensitivity analysis for each compound.
    Type: Grant
    Filed: July 3, 2014
    Date of Patent: June 11, 2019
    Assignee: SHIMADZU CORPORATION
    Inventor: Takashi Sumiyoshi
  • Patent number: 10317362
    Abstract: The invention relates to methods for the detailed analysis of ion mixtures from complex mixtures of organic substances in time-of-flight mass spectrometers which are equipped with a trapped ion mobility spectrometer, a quadrupole mass selector and a fragmentation cell. The invention proposes to analyze ion signals of a first mass mobility map, fragment ion spectra and the identifications of the associated substances as to whether ion mixtures not resolved according to mass and mobility, for example from isomers or isobars, are possibly present, and to subsequently measure the ion signals of interest with method parameters which allow the ion species to be measured separately by means of high mobility resolution.
    Type: Grant
    Filed: May 25, 2017
    Date of Patent: June 11, 2019
    Inventors: Alexander Harder, Markus Lubeck, Sven Myer, Detlev Suckau
  • Patent number: 10317366
    Abstract: A first shutter gate is disposed at an entrance of a drift region, and a second shutter gate is disposed on the downstream side in an ion-drifting direction. In a high-resolution measurement mode, a controller (9) controls voltage generators to open the second shutter gate to collect ions into a pulsed form at the first shutter gate. In this mode, the controller controls the voltage generators to open the first shutter gate to collect ions into a pulsed form at the second shutter gate. In a zoom-in measurement mode where ions within a specified range of ion mobility are measured with high resolving power, the controller controls the voltage generators to open the first shutter gate for a short period of time, and then to open the second shutter gate for a short period of time after a lapse of a predetermined time period.
    Type: Grant
    Filed: September 9, 2015
    Date of Patent: June 11, 2019
    Assignee: SHIMADZU CORPORATION
    Inventors: Motohide Yasuno, Akiko Imazu
  • Patent number: 10319575
    Abstract: A method of mass or ion mobility spectrometry is disclosed. The method comprises providing a spectrometer comprising an orifice between an atmospheric and a sub-atmospheric pressure region of the spectrometer, wherein the latter comprises an ion guide or ion trap; providing a sample probe comprising a needle assembly on which a sample is deposited or that is supplied with a sample; inserting the needle assembly through the orifice into the sub-atmospheric pressure region so that the sample is arranged within or adjacent to the ion guide or trap in the sub-atmospheric pressure region; and then desorbing the sample from the needle assembly within the sub-atmospheric pressure region and/or ionizing the sample within the sub-atmospheric pressure region so as to generate ions that enter the ion guide or ion trap. The proximity of the sample to the ion guide or trap allows analyte ions from the sample to be captured efficiently.
    Type: Grant
    Filed: August 5, 2015
    Date of Patent: June 11, 2019
    Assignee: MICROMASS UK LIMITED
    Inventors: Jeffery Mark Brown, Martin Raymond Green
  • Patent number: 10317412
    Abstract: In a mass spectrum of fragment ions obtained by dissociating peptide-derived ions using the technique of irradiating the ions with hydrogen radicals, either pairs of a-type and c-type ions or those of z-type and z-type ions are characteristically observed. Since the mass difference of those ion pairs is previously known, a pair peak searcher 92 searches for pair peaks having a predetermined mass difference in a mass spectrum created by a mass spectrum creator 91, and adds to the detected pair peaks a piece of information indicating that they are pairs of a-type and c-type ions or those of x-type and z-type ions. When estimating the amino acid sequence of the peptide by a database search, a protein identifier 93 uses the ion-pair information in addition to the m/z value of each peak, whereby the accuracy of the estimation or identification the amino acid sequence can be improved.
    Type: Grant
    Filed: December 27, 2017
    Date of Patent: June 11, 2019
    Assignee: SHIMADZU CORPORATION
    Inventors: Sadanori Sekiya, Hidenori Takahashi