Ionic Separation Or Analysis Patents (Class 250/281)
  • Patent number: 11913924
    Abstract: The invention generally relates to ion generation using modified wetted porous materials. In certain aspects, the invention generally relates to systems and methods for ion generation using a wetted porous substrate that substantially prevents diffusion of sample into the substrate. In other aspects, the invention generally relate to ion generation using a wetted porous material and a drying agent. In other aspects, the invention generally relates to ion generation using a modified wetted porous substrate in which at least a portion of the porous substrate includes a material that modifies an interaction between a sample and the substrate.
    Type: Grant
    Filed: March 30, 2023
    Date of Patent: February 27, 2024
    Assignee: Purdue Research Foundation
    Inventors: Robert Graham Cooks, Zheng Ouyang
  • Patent number: 11908670
    Abstract: A method of performing mass spectrometry includes accessing a series of mass spectra of detected ions derived from components eluting from a chromatography column; obtaining, based on the series of mass spectra, an elution profile including a plurality of detection points representing intensity of at least a set of the detected ions as a function of time; and determining, based on a set of detection points included in the plurality of detection points, a predicted next detection point of the elution profile to be obtained based on a next mass spectrum to be acquired subsequent to acquisition of the series of mass spectra.
    Type: Grant
    Filed: May 16, 2022
    Date of Patent: February 20, 2024
    Assignee: Thermo Finnigan LLC
    Inventors: Philip M. Remes, Jesse D. Canterbury
  • Patent number: 11898975
    Abstract: The electron spectrometer includes an excitation part 100 irradiating a sample with an energy beam, an orbiting part 10 causing electrons emitted from the sample irradiated with the energy beam to orbit, and a detection part 120 detecting the electrons released from the orbiting part 10, in which the orbiting part 10 includes a plurality of pairs of electrodes, the plurality of pairs of electrodes cause the electrons to orbit when an applied voltage is controlled, a part of the plurality of pairs of electrodes are pairs of electrodes to catch which catch the electrons into the orbiting part 10 when an applied voltage is controlled, and a part of the plurality of pairs of electrodes are pairs of electrodes to release which release the electrons from the orbiting part 10 when an applied voltage is controlled.
    Type: Grant
    Filed: February 23, 2022
    Date of Patent: February 13, 2024
    Assignee: TOHOKU UNIVERSITY
    Inventors: Masahiko Takahashi, Isao Nakajima, Yuuki Onitsuka
  • Patent number: 11894147
    Abstract: A method for predicting an unfavorable outcome for a patient admitted to a hospital, e.g., with a COVID-19 infection is described. Attributes from an electronic health record for the patient are obtained including at least findings obtained at admission, basic patient characteristics, and laboratory data. The attributes are supplied to a classifier implemented in a programmed computer which is trained to predict a risk of the unfavorable outcome. The classifier is arranged as a hierarchical combination of (a) an initial binary classifier stratifying the patient into either a high risk group or a low risk group, and (b) child classifiers further classifying the patient in a lowest risk group or a highest risk group depending how the initial binary classifier stratified the patient as either a member of the high risk or low risk group.
    Type: Grant
    Filed: September 2, 2022
    Date of Patent: February 6, 2024
    Assignee: BIODESIX, INC.
    Inventors: Thomas Campbell, Robert W. Georgantas, III, Heinrich Röder, Joanna Röder, Laura Maguire
  • Patent number: 11887832
    Abstract: An isotope ratio mass spectrometer has an ion source, a static field mass filter, a reaction cell to induce a mass shift reaction, and a sector field mass analyser for spatially separating ions from the reaction cell according to their m/z. A detector platform detects a plurality of different ion species separated by the sector field mass analyser. The static field mass filter has a first Wien filter that deflects ions away from a longitudinal symmetry axis of the spectrometer in accordance with the ions' m/z, and a second Wien filter that deflects ions back towards the longitudinal symmetry axis in accordance with the ions' m/z. An inverting lens is positioned along the longitudinal axis between the Wien filters to invert the direction of deflection of the ions from the first Wien filter. The static field mass filter provides high transmission and improved spectrometer sensitivity. The first and second Wien filters permit simple tuning.
    Type: Grant
    Filed: March 24, 2022
    Date of Patent: January 30, 2024
    Assignee: Thermo Fisher Scientific (Bremen) GmbH
    Inventors: Johannes Schwieters, Gerhard Jung
  • Patent number: 11885811
    Abstract: The present invention provides rapid, sensitive high-throughput methods and systems for characterizing peptides or proteins using hydrophobic interaction chromatography-coupled native mass spectrometry to improve manufacturing process of biopharmaceutical products, such as identifying impurities during antibody purification, monitoring post-translational modification variants during production, or characterizing drug-to-antibody ratio of antibody-drug conjugates. The separation profiles of the peptides or proteins are generated and compared to identify or qualify the peptides or proteins.
    Type: Grant
    Filed: November 7, 2022
    Date of Patent: January 30, 2024
    Assignee: Regeneron Pharmaceuticals, Inc.
    Inventors: Yuetian Yan, Shunhai Wang
  • Patent number: 11881387
    Abstract: Apparatus and method are proposed for the strong improvement of dynamic range (DR) of detectors and of data systems for time-of-flight mass spectrometers (TOF MS) with periodically repetitive signals. TOF separated ions are converted into secondary particles, primarily electrons, and the flow of secondary particles is controllably attenuated to sustain the data acquisition system in a counting mode above the electronic noise threshold. The acquisition time is split between at least two time segments, characterized by alternated transmission efficiency SE of secondary particles. Using strong electron suppression (SE«1) is employed for recording intense ion peak, while counting ions with either ADC, or TDC, or ADC with extracting peak centroids. A longer time segment employs an efficient electron transfer (SE=1) for detecting weak ion species.
    Type: Grant
    Filed: May 23, 2019
    Date of Patent: January 23, 2024
    Assignee: Micromass UK Limited
    Inventor: Anatoly Verenchikov
  • Patent number: 11875982
    Abstract: Techniques and systems for multi-modal ionization for mass spectrometry are provided. In some embodiments, a method may comprise: receiving an analyte; ionizing some molecules of the analyte using a first ionization method to produce first ions; ionizing other molecules of the analyte using a second ionization method to produce second ions; and providing the first and second ions to a mass analyzer.
    Type: Grant
    Filed: February 17, 2023
    Date of Patent: January 16, 2024
    Assignee: BaySpec, Inc.
    Inventors: Nam Duc Lai, Krisztian Gabor Torma, Ming Chai, William Allen Escobar, Xiaoguang Wu, Masayuki Kamata, Wei Yang Terziyan
  • Patent number: 11874252
    Abstract: An apparatus for ion manipulation having improved duty cycle includes first and second separation regions separated by a switch that alternates between guiding ions to each of the separation regions. The separation regions separate the ions based on mobility over respective time periods that at least partially overlap. The apparatus can additionally or alternatively include a pre-separation region that filters ions prior to accumulating ions, thus allowing an accumulation region to accumulate for a longer time period. The apparatus can additionally or alternatively include a plurality of gates along the separation region(s) to simultaneously filter a plurality of ion packets sequentially released into the separation region(s).
    Type: Grant
    Filed: June 3, 2021
    Date of Patent: January 16, 2024
    Assignee: MOBILion Systems, Inc.
    Inventors: John Daniel DeBord, Liulin Deng, Nathan Paul Roehr
  • Patent number: 11869634
    Abstract: A system and method for automated detection of the presence or absence of a quantity based on intensities expressed in terms of, or derived from frequency or time dependent data. According to one example intensities from mass spectrometry are identified using a non-linear mathematical model, such as an artificial neural network trained to find start and stop peaks of an intensity, from which an abundance may be determined.
    Type: Grant
    Filed: March 27, 2020
    Date of Patent: January 9, 2024
    Assignee: VENN BIOSCIENCES CORPORATION
    Inventors: Daniel Serie, Zhenqin Wu
  • Patent number: 11861826
    Abstract: At the time of superimposing and aligning a stained image and a mass spectrometric (MS) image obtained for the same sample, an image display processor displays, on the superimposed images, grid lines (62) at the spacing corresponding to an operation of a grid spacing adjustment slider (63). When an operator depresses an image deformation range “SET” button (64), specifies an arbitrary area on the superimposed images with a mouse, and then depresses a “SELECT” button (65), an image deformation range specification receiving section determines an image deformation range. When the operator selects an intersection (grid point) of the grid lines (62) within the image deformation range and performs an operation of moving the intersection point to an arbitrary position, an image deformation processor deforms an image included in the image deformation range in accordance with the operation.
    Type: Grant
    Filed: May 30, 2018
    Date of Patent: January 2, 2024
    Assignee: SHIMADZU CORPORATION
    Inventor: Shinichi Yamaguchi
  • Patent number: 11854778
    Abstract: A method for the identification and localization of small molecule species in a histologic thin tissue section comprises the steps of: a) acquiring a mass/mobility image of the tissue section and generating a mass/mobility map of the small molecule species of interest for each pixel of the image; b) providing a second sample of the same tissue and extracting the small molecules of interest, separating them, and acquiring mass and ion mobility spectra from the separated small molecules; c) identifying the small molecules of interest using corresponding reference databases; and d) assigning identified small molecules to entries in the mass/mobility maps of the first tissue section by comparison of ion masses and mobilities of the identified species to those of the second thin tissue section.
    Type: Grant
    Filed: January 3, 2023
    Date of Patent: December 26, 2023
    Inventor: Michael Easterling
  • Patent number: 11854780
    Abstract: Exemplary embodiments provide methods, mediums, and systems for comparing a sample of interest to a library of known compounds to quickly determine how similar the sample is to the compounds in the library. Peaks of interest in the sample data are compared to corresponding peaks in the library compound data. These peaks may be represented as vectors, and an angle between the sample vector and the library vector may be used as a similarity metric. In some embodiments, a cosine similarity may be calculated for the vectors. If the similarity score for a given library compound/sample pair exceed a threshold, then the system determines that the library compound and the sample are similar and takes appropriate action. Various parameters associated with the comparison can be adjusted in order to improve the quality of the results and/or the efficiency of the process.
    Type: Grant
    Filed: October 13, 2021
    Date of Patent: December 26, 2023
    Assignee: WATERS TECHNOLOGIES IRELAND LIMITED
    Inventors: Nathaniel Martin, Nicola Lumley, David S. Douce, David Jackson
  • Patent number: 11854781
    Abstract: The invention generally relates to electrophoretic mass spectrometry probes and systems and methods of uses thereof. In certain aspects, the invention provides a mass spectrometry probe having a hollow body with a distal tip, an electrically conductive hollow conduit, and an electrode. The electrically conductive hollow conduit may be operably coupled to a reservoir and a power source, and the electrically conductive hollow conduit may be configured to transport a liquid sample into the hollow body and polarize the liquid sample as it flows through the electrically conductive hollow conduit and into in the hollow body. The electrode and the electrically conductive hollow conduit are disposed within the hollow body (e.g., at different heights within the hollow body).
    Type: Grant
    Filed: November 2, 2022
    Date of Patent: December 26, 2023
    Assignees: Purdue Research Foundation, AMGEN INC.
    Inventors: Robert Graham Cooks, Tawnya Flick
  • Patent number: 11848184
    Abstract: An ion guide (20) provided in a first intermediate vacuum chamber includes six rod electrodes (211 to 216) and a voltage generation unit. The six rod electrodes (211 to 216) are in a hexapole arrangement on the ion incident side, and the two rod electrodes (211 and 214) are tilted with respect to the Z-axis in a manner approaching a central axis (201) as they progress in the ion transport direction, so that the four rod electrodes (211, 214, 215, and 216) are in a quadrupole arrangement. The voltage generation unit applies radio-frequency voltages ±V cos ?t whose phases are inverted to each other between adjacent rod electrodes of the six rod electrodes (211 to 216) around the central axis (201), applies a DC voltage U1 to the four electrodes (211, 214, 215, and 216) by which ions pass through them in an excellent manner, and applies a DC voltage U2 different from U1 to the other two rod electrodes (212 and 213).
    Type: Grant
    Filed: December 19, 2018
    Date of Patent: December 19, 2023
    Assignee: SHIMADZU CORPORATION
    Inventor: Masaru Nishiguchi
  • Patent number: 11848181
    Abstract: Intensity measurements made by electron multiplier and image-charge detectors are proportional to charge state. These intensities are used to separate detected ions into different data sets and create mass spectra from the different data sets. Ion measurements are separated by charge state using (i) a single electron multiplier detector, (ii) a single image-charge detector, or (iii) multiple electron multiplier ADC detectors. Using (i), the intensity of a peak calculated from each measured pulse is compared to predetermined intensity ranges and each peak is stored in a corresponding data set. Using (ii), each measured transient time-domain signal is converted to frequency-domain peaks, the intensity of each frequency-domain peak is compared to predetermined intensity ranges, and each peak is stored in a corresponding data set. Using (iii), each detector is adapted to measure a predetermined intensity range and store calculated peaks from the measured pulses in corresponding data sets.
    Type: Grant
    Filed: January 31, 2020
    Date of Patent: December 19, 2023
    Assignee: DH Technologies Development Pte. Ltd.
    Inventors: Pavel Ryumin, Takashi Baba, Nic G. Bloomfield
  • Patent number: 11848183
    Abstract: Devices and methods for surface-induced dissociation (SID) are disclosed. In one aspect, a device for SID is disclosed which, in one embodiment includes a collision surface, a deflector configured to guide precursor ions from a pre-SID region to the collision surface to cause SID, and an ion carpet having applied electrical properties configured to guide product ions resulting from collision with the collision surface to a post-SID region. In another aspect, a method for SID is disclosed which, in one embodiment includes guiding, by a deflector, precursor ions from a pre-SID region to a collision surface to cause SID, and guiding, by an ion carpet having selected applied electrical properties, product ions resulting from collision with the collision surface to a post-SID region.
    Type: Grant
    Filed: December 26, 2019
    Date of Patent: December 19, 2023
    Assignee: Ohio State Innovation Foundation
    Inventors: Vicki Wysocki, Joshua Gilbert, Alyssa Stiving
  • Patent number: 11842892
    Abstract: Ions are injected into an orbital electrostatic trap. An ejection potential is applied to an ion storage device, to cause ions stored in the ion storage device to be ejected towards the orbital electrostatic trap. Synchronous injection potentials are applied to a central electrode of the orbital electrostatic trap and a deflector electrode associated with the orbital electrostatic trap, to cause the ions ejected from the ion storage device to be captured by the electrostatic trap such that they orbit the central electrode. Application of the ejection potential and application of the synchronous injection potentials are each started at respective different times, the difference in times being selected based on desired values of mass-to-charge ratios of ions to be captured by the orbital electrostatic trap.
    Type: Grant
    Filed: April 19, 2022
    Date of Patent: December 12, 2023
    Assignee: Thermo Fisher Scientific (Bremen) GmbH
    Inventors: Mikhail Belov, Eduard Denisov, Gregor Quiring, Dmitry Grinfeld
  • Patent number: 11837455
    Abstract: The invention generally relates to sample analysis systems and methods of use thereof. In certain aspects, the invention provides a system for analyzing a sample that includes an ion generator configured to generate ions from a sample. The system additionally includes an ion separator configured to separate at or above atmospheric pressure the ions received from the ion generator without use of laminar flowing gas, and a detector that receives and detects the separated ions.
    Type: Grant
    Filed: June 3, 2022
    Date of Patent: December 5, 2023
    Assignee: Purdue Research Foundation
    Inventors: Robert Graham Cooks, Zane Baird, Pu Wei
  • Patent number: 11837451
    Abstract: A method for cleaning an electrospray emitter of a mass spectrometer comprises the steps of: (a) changing a mode of operation of the electrospray emitter from a stable jet mode of operation to a dripping mode or a pulsating mode of operation by lowering a magnitude, |V|, of a voltage applied between a counter electrode and the electrospray emitter; and (b) changing the mode of operation of the electrospray emitter from the dripping mode or the pulsating mode of operation to the stable jet mode of operation by increasing the magnitude, |V|, of the applied voltage; wherein the repetitions are performed at a predetermined frequency that depends on one or more of liquid flow rate, an emitter internal diameter, and liquid properties.
    Type: Grant
    Filed: January 10, 2023
    Date of Patent: December 5, 2023
    Assignee: Thermo Finnigan LLC
    Inventors: Joshua A. Silveira, Michael L. Poltash, Wei Wei, Eloy R. Wouters
  • Patent number: 11828724
    Abstract: An ion guide electrode assembly (10) for an ion-mobility spectrometer is described. The electrode assembly (10) comprises a first sheet (100), having first and second surfaces (110, 120) comprising a plurality of corresponding regions (111, 112, 121, 122). The first sheet (100) comprises a set of N electrodes (130, 140), including a first electrode (130) and a second electrode (140), provided as tracks mutually spaced apart on the first surface (110) thereof. The electrode assembly (10) is arrangeable in a planar configuration and preferably in a tubular configuration. In the tubular configuration, a first part (131) of the first electrode (130), provided in a first region 111 of the first surface (110), overlays a second region (122) of the second surface (120).
    Type: Grant
    Filed: March 15, 2019
    Date of Patent: November 28, 2023
    Assignee: THE UNIVERSITY OF LIVERPOOL (INC. IN THE UK)
    Inventors: Simon Maher, Cedric Claude Boisdon
  • Patent number: 11830717
    Abstract: The invention generally relates to apparatuses for focusing ions at or above ambient pressure and methods of use thereof. In certain embodiments, the invention provides an apparatus for focusing ions that includes an electrode having a cavity, at least one inlet within the electrode configured to operatively couple with an ionization source, such that discharge generated by the ionization source is injected into the cavity of the electrode, and an outlet. The cavity in the electrode is shaped such that upon application of voltage to the electrode, ions within the cavity are focused and directed to the outlet, which is positioned such that a proximal end of the outlet receives the focused ions and a distal end of the outlet is open to ambient pressure.
    Type: Grant
    Filed: April 14, 2023
    Date of Patent: November 28, 2023
    Assignee: Purdue Research Foundation
    Inventors: Robert Graham Cooks, Zane Baird, Wen-Ping Peng
  • Patent number: 11823883
    Abstract: An ion detector for secondary ion mass spectrometer, the detector having an electron emission plate coupled to a first electrical potential and configured to emit electrons upon incidence on ions; a scintillator coupled to a second electrical potential, different from the first electrical potential, the scintillator having a front side facing the electron emission plate and a backside, the scintillator configured to emit photons from the backside upon incidence of electrons on the front side; a lightguide coupled to the backside of the scintillator and confining flow of photons emitted from the backside of the scintillator; and a solid-state photomultiplier coupled to the light guide and having an output configured to output electrical signal corresponding to incidence of photons from the lightguide. A SIMS system includes a plurality of such detectors movable arranged over the focal plane of a mass analyzer.
    Type: Grant
    Filed: November 19, 2021
    Date of Patent: November 21, 2023
    Assignee: NOVA MEASURING INSTRUMENTS, INC.
    Inventors: Christopher F. Bevis, Yungman Alan Liu, David Allen Reed, Eli Cheifetz, Amit Weingarten, Alexander Kadyshevitch
  • Patent number: 11823885
    Abstract: A method for analyzing a sample collected from a surface, the method comprising placing at least a portion of a substrate having a pressure sensitive adhesive layer containing the sample in a holder, adding a spray solvent to the sample-containing pressure sensitive adhesive layer, and analyzing the sample contained in the pressure sensitive adhesive layer and the spray solvent using paper spray mass spectrometry.
    Type: Grant
    Filed: December 18, 2020
    Date of Patent: November 21, 2023
    Assignees: The Trustees of Indiana University, The U.S. Government as Represented by the U.S. Army Combat Capabilities Development Command
    Inventors: Nicholas Edward Manicke, William Raymond Anthony Wichert, Ethan M. McBride, Trevor G. Glaros, Phillip M. Mach
  • Patent number: 11817669
    Abstract: In this patent, we teach methods to generate coherent X-ray and UUV rays beams for X ray and UUV microscopes using intense femtosecond pulses resulting the Ultra-Supercontinuum (USC) and Higher Harmonic Generation (HHG) from ?3 and ?5 media produce from electronic and molecular Kerr effect. The response of n2 (?3) and n4 (?5) at the optical frequency from instantaneously response of carrier phase of envelope results in odd HHG and spectral broadening about each harmonic on the anti-Stokes side of the pump pulse at wo typically in the visible, NIR, and MIR. From the slower molecular Kerr response on femtosecond to picosecond from orientation and molecular motion on n2 and n4 which follow the envelope of optical field of the laser gives rise to extreme broadening without HHG. The resulting spectra extend on the Stokes side towards the IR, RF to DC covering most of the electromagnetic spectrum. These HHG and Super broadening covering UUV to X rays and possibly to gamma ray regime for microscopes.
    Type: Grant
    Filed: November 22, 2021
    Date of Patent: November 14, 2023
    Inventor: Robert R. Alfano
  • Patent number: 11817301
    Abstract: A signal processing unit comprises: at least one data signal input line adapted to receive a measured data signal generated by an image current, the measured data signal comprising an added crosstalk signal induced by a source of electromagnetic disturbance; at least one disturbance signal input line adapted to receive a decoupled disturbance signal, extracted from the source of electromagnetic disturbance; an output line adapted to supply a compensated data signal; a conditioning module, to which the decoupled disturbance signal is supplied via the disturbance signal input line and which provides a compensation signal; and an adding module, to which the measured data signal and the compensation signal are provided and in which the measured data signal and the compensation signal are superposed, whereby the decoupled disturbance signal is conditioned by the conditioning module such that the compensation signal essentially corresponds to an inverted added crosstalk signal.
    Type: Grant
    Filed: June 10, 2022
    Date of Patent: November 14, 2023
    Assignee: Thermo Fisher Scientific (Bremen) GmbH
    Inventors: Alexander Kholomeev, Gregor Quiring, Frank Czemper
  • Patent number: 11810773
    Abstract: A mass spectrometry method comprises: introducing a first packet of ions into an electrostatic trap mass analyzer through a set of electrostatic lenses, wherein, during the introducing of the first packet, either the lenses are operated in a first mode of operation or an injection voltage of a first pre-determined magnitude is applied to an electrode of the mass analyzer; mass analyzing the first ion packet using the mass analyzer; introducing a second packet of ions into the mass analyzer through the set of lenses, wherein, during the introducing of the second packet, either the lenses are operated in a second mode of operation or an injection voltage of a second pre-determined magnitude is applied to the electrode of the mass analyzer; and mass analyzing the second packet of ions using the electrostatic trap mass analyzer.
    Type: Grant
    Filed: January 24, 2023
    Date of Patent: November 7, 2023
    Assignee: Thermo Finnigan LLC
    Inventors: Jesse D. Canterbury, Michael W. Senko
  • Patent number: 11810772
    Abstract: In one aspect, a method of processing ions in a mass spectrometer is disclosed, which comprises trapping a plurality of ions having different mass-to-charge (m/z) ratios in a collision cell, releasing said ions from the collision cell in a descending order in m/z ratio, and receiving the ions in a mass analyzer having a plurality of rods to at least one of which an RF voltage is applied, where the RF voltage is varied from a first value to a lower second value as the released ions are received by the mass analyzer.
    Type: Grant
    Filed: April 28, 2022
    Date of Patent: November 7, 2023
    Assignee: DH Technologies Development Pte. Ltd.
    Inventor: Mircea Guna
  • Patent number: 11798656
    Abstract: One aspect of the invention provides a computer-implemented method of identifying a species from mass spectra. The computer-implemented method includes: loading a data set including a species and associated mass spectra into memory on a computer; for each of the associated mass spectra, pre-processing to identify ranks of intensities of an in-bin peak across bins defining ranges of mass-to-charge ratio; and training a species binary classifier for each of a plurality of species using at least the ranks of intensities. Another aspect of the invention provides a system for identifying a species from mass spectra. The system includes: a processor; and computer-readable memory containing instructions to: implement an interface programmed to receive mass spectra; store the mass spectra in the computer-readable memory; and invoke execution of any of the methods described herein on the processor.
    Type: Grant
    Filed: January 21, 2020
    Date of Patent: October 24, 2023
    Assignee: Nevada Research & Innovation Corporation
    Inventor: So Young Ryu
  • Patent number: 11789026
    Abstract: Methods are described for measuring the amount of C peptide in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying C peptide in a sample utilizing on-line extraction methods coupled with tandem mass spectrometric or high resolution/high accuracy mass spectrometric techniques.
    Type: Grant
    Filed: May 27, 2022
    Date of Patent: October 17, 2023
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Nigel Clarke, Zhaohui Chen
  • Patent number: 11791144
    Abstract: An optimization control system may receive mass spectra of ions emitted from an ionization emitter toward an inlet of a mass spectrometer and control, based on the mass spectra, an automated motion system to adjust a position of the emitter relative to the inlet.
    Type: Grant
    Filed: March 10, 2021
    Date of Patent: October 17, 2023
    Assignee: Thermo Finnigan LLC
    Inventors: Bennett S. Kalafut, Joshua A. Silveira, Abhishek Joshi, Eloy R. Wouters
  • Patent number: 11784036
    Abstract: The invention relates to the generation of desolvated ions by electrospraying to be investigated analytically, e.g. according to the charge-related mass m/z and/or ion mobility. The cloud of highly charged droplets drawn from the spray capillary by a high voltage is usually focused and stabilized by a beam of nebulizing gas surrounding the cloud of tiny droplets. For a fast drying of the droplets, an additional desolvation gas is usually heated to a temperature of up to several hundred degrees centigrade and blown into the cloud of droplets. The invention particularly relates to the heating of the gas which is instrumental in the generation of desolvated ions as part of the electrospraying process without any mechanical or electrical contact between the heating power supply and the heater itself, but rather by heating the heater for the gas using electromagnetic induction.
    Type: Grant
    Filed: May 6, 2021
    Date of Patent: October 10, 2023
    Inventors: Anil Mavanur, Felician Muntean
  • Patent number: 11784034
    Abstract: A method for analyzing secondary ion mass spectrum data representing respective secondary ion counts for a range of masses at a given mass resolution. The mass spectrum data is obtained by Secondary Ion Mass Spectrometry, SIMS. Automatic quantification of the ion species and/or cluster ions detected in the analyzed spectrum data is provided.
    Type: Grant
    Filed: December 23, 2019
    Date of Patent: October 10, 2023
    Assignee: LUXEMBOURG INSTITUTE OF SCIENCE AND TECHNOLOGY (LIST)
    Inventors: Patrick Philipp, Tom Wirtz
  • Patent number: 11785705
    Abstract: A device may include a temperature controlled chamber. The temperature controlled chamber may be coupled to a plurality of strengthening coated capillary tubes. The strengthening coated capillary tubes may support the temperature controlled chamber and provide thermal insulation to the temperature controlled chamber.
    Type: Grant
    Filed: November 17, 2020
    Date of Patent: October 10, 2023
    Assignee: Xerox Corporation
    Inventor: Yunda Wang
  • Patent number: 11769655
    Abstract: A method of performing targeted multiplexed mass spectrometry includes performing, at a mass spectrometer, a targeted MS3 analysis of an isobaric tag-labeled target analyte included in a multiplex sample eluting from a column. The targeted MS3 analysis is performed during an acquisition segment scheduled based on an expected retention time of the isobaric tag-labeled target analyte. The method further includes performing, during the acquisition segment, a plurality of MS2 analyses of product ions derived from components included in the multiplex sample and eluting from the column. The method further includes determining, based on MS3 mass spectra acquired by the targeted MS3 analysis and MS2 mass spectra acquired by the plurality of MS2 analyses, a relative quantity of the isobaric tag-labeled target analyte in the multiplex sample.
    Type: Grant
    Filed: October 5, 2021
    Date of Patent: September 26, 2023
    Assignee: Thermo Finnigan LLC
    Inventor: Philip M. Remes
  • Patent number: 11764044
    Abstract: A method for deconvoluting measured mass spectrometry data, the method comprising: receiving measured mass spectrometry data representing at least two molecular moieties each having a respective isotopic pattern, wherein at least two of said isotopic patterns overlap; iteratively filling a set of mass channels to produce an approximated version of the mass spectrometry data, said iterative filling comprising a number of iterations, each iteration comprising filling one or more of the mass channels with a chunk of intensity data according to the isotopic pattern of a respective one of the two or more molecular moieties selected for said iteration; terminating said iterative filling when a fitness criterion is met indicating a fit of the approximated version of the mass spectrometry data to the measured mass spectrometry data; and determining the amount of each molecular moiety that produced the measured mass spectrometry data based on the total amount of fills according to the respective isotopic pattern of sa
    Type: Grant
    Filed: March 25, 2022
    Date of Patent: September 19, 2023
    Inventors: Frank Berg, Robert Malek, Kai Fritzemeier
  • Patent number: 11761926
    Abstract: In DM-SWATH a plurality of CoVs and a precursor ion mass range are received. A processor performs an iterative series of steps for each CoV of the plurality of CoVs. For each CoV of the plurality of CoVs, the CoV is applied to the DMS device to select a group of precursor ions. A mass filter is instructed to select precursor ions of the group that are within the precursor ion mass range, producing a subgroup of precursor ions. A fragmentation device is instructed to fragment the subgroup of precursor ions, producing a group of product ions. A mass analyzer is instructed to measure the intensity and m/z of the group of product ions, producing a product ion spectrum for each CoV of the plurality of CoVs. DM-SWATH is further used to validate if a known compound is in a sample.
    Type: Grant
    Filed: July 22, 2022
    Date of Patent: September 19, 2023
    Assignee: DH Technologies Development Pte. Ltd.
    Inventors: Yves Le Blanc, Brendon Seale
  • Patent number: 11761887
    Abstract: An apparatus and a method for quantitative detection of gases are provided. The apparatus for quantitative detection of gases includes: a cavity ring-down spectroscopy device configured to quantitatively detect any characteristic gas in gases to be detected; a sample processing device disposed in a downstream of the cavity ring-down spectroscopy device and connected to the cavity ring-down spectroscopy device; and a mass spectrometry device disposed in a downstream of the sample processing device and configured to detect all the gases to be detected. Quantitative analysis of any variety of gases may be achieved without using standard gas in the technical solution proposed by the present application. Since no standard gas is required, the technology has significantly increased flexibility, and can be used for routine laboratory testing, for online analysis at industrial sites, as well as detection and analysis in environmental protection, national defense, aviation, aerospace, military and other fields.
    Type: Grant
    Filed: April 23, 2020
    Date of Patent: September 19, 2023
    Inventors: Zejian Huang, Xiang Fang, Xinhua Dai, You Jiang
  • Patent number: 11754536
    Abstract: Disclosed are methods, libraries, and samples for quantifying a target analyte in a laboratory sample including the target analyte. The methods typically include the step of estimating the amount of the target analyte in the laboratory sample from mass spectrometric data including signal intensities for the target analyte and one or more internal standards, where the mass spectrometric data are an output of a mass spectrometric analysis of a target sample produced from the laboratory sample and a predetermined amount of the one or more internal standards. The present disclosure also provides a method for analyte quantification. The method comprises adding one or more calibrators to a sample comprising one or more analytes; applying mass spectrometry (MS) to the sample; and using a trained machine learning model to determine an absolute concentration of the one or more analytes.
    Type: Grant
    Filed: September 7, 2022
    Date of Patent: September 12, 2023
    Assignee: MATTERWORKS INC
    Inventors: Timothy Kassis, Jefferson Pruyne, Mark D. Simon, Mimoun Cadosch Delmar Akerman, Jennifer Campbell, Ana Henriques Da Costa, Laura Kolinsky, John M. Geremia
  • Patent number: 11754526
    Abstract: A method of evaluating an analysis device that is capable of detecting each of a plurality of compounds included in a sample includes introducing the sample including a first compound into the analysis device for measurement and detecting the first compound and at least one reaction product derived from the first compound, and acquiring information representing whether the analysis device is in a suitable state for an analysis based on an intensity of the detected first compound and an intensity of each of the detected at least one reaction product, and a relative response factor in regard to each of the first compound and the at least one reaction product.
    Type: Grant
    Filed: December 17, 2018
    Date of Patent: September 12, 2023
    Assignee: SHIMADZU CORPORATION
    Inventor: Yukihiko Kudo
  • Patent number: 11756779
    Abstract: An apparatus includes a tubular connector having a longitudinal axis. The connector includes a first end that connects to a first analytical system, a second end that connects to a second analytical system, and a flexible portion between the first end and the second end that curves in a direction transverse to the axis of the connector such that the connector contains ion guides to transfer ions between the first analytical system and the second analytical system.
    Type: Grant
    Filed: January 6, 2022
    Date of Patent: September 12, 2023
    Assignee: Trace Matters Scientific LLC
    Inventor: Mazdak Taghioskoui
  • Patent number: 11749518
    Abstract: A package-level, integrated high-vacuum ion-chip enclosure having improved thermal characteristics is disclosed. Enclosures in accordance with the present invention include first and second chambers that are located on opposite sides of a chip carrier, where the chambers are fluidically coupled via a conduit through the chip carrier. The ion trap is located in the first chamber and disposed on the chip carrier. A source for generating an atomic flux is located in the second chamber. The separation of the source and ion trap in different chambers affords thermal isolation between them, while the conduit between the chambers enables the ion trap to receive the atomic flux.
    Type: Grant
    Filed: June 26, 2020
    Date of Patent: September 5, 2023
    Assignee: Duke University
    Inventors: Jungsang Kim, Kai Hudek, Geert Vrijsen, Robert Spivey, Peter Maunz
  • Patent number: 11742194
    Abstract: The present invention is directed to a method and device to desorb an analyte using heat to allow desorption of the analyte molecules, where the desorbed analyte molecules are ionized with ambient temperature ionizing species. In various embodiments of the invention a current is passed through a mesh upon which the analyte molecules are present. The current heats the mesh and results in desorption of the analyte molecules which then interact with gas phase metastable neutral molecules or atoms to form analyte ions characteristic of the analyte molecules.
    Type: Grant
    Filed: June 24, 2021
    Date of Patent: August 29, 2023
    Inventors: Jordan Krechmer, Brian D. Musselman
  • Patent number: 11742192
    Abstract: A method of mass spectral analysis in an analytical electrostatic trap (14) is disclosed. The electrostatic trap (14) defines an electrostatic field volume and includes trap electrodes having static and non-ramped potentials. The method comprises injecting a continuous ion beam into the electrostatic field volume.
    Type: Grant
    Filed: September 17, 2019
    Date of Patent: August 29, 2023
    Assignee: LECO Corporation
    Inventor: Anatoly N. Verenchikov
  • Patent number: 11740246
    Abstract: Methods for achieving complete sequence coverage of monoclonal antibodies by trypsin digestion and dual-column LC-MS system are provided. The disclosed method improves upon current techniques for standard peptide mapping.
    Type: Grant
    Filed: July 25, 2022
    Date of Patent: August 29, 2023
    Assignee: Regeneron Pharmaceuticals, Inc.
    Inventor: Shunhai Wang
  • Patent number: 11735408
    Abstract: An ion analyzer that generates and analyzes product ions by irradiating precursor ions derived from a sample component with radicals, the ion analyzer including: a reaction chamber (2; 833) into which the precursor ions are introduced; a radical generation unit (5) configured to generate radicals from a first material gas; a metastable particle generation unit (5) configured to generate metastable particles from a second material gas; a radical introduction unit (5) configured to mix the radical and the metastable particles and introduce the mixture into the reaction chamber (2; 833); and an ion detection unit (4; 835) configured to detect product ions generated from the precursor ions by a reaction with the radicals.
    Type: Grant
    Filed: January 23, 2019
    Date of Patent: August 22, 2023
    Assignee: SHIMADZU CORPORATION
    Inventor: Hidenori Takahashi
  • Patent number: 11728148
    Abstract: A dissociation device fragments a precursor ion, producing at least two different product ions with overlapping m/z values in the dissociation device. The dissociation device applies an AC voltage and a DC voltage creating a pseudopotential that traps ions below a threshold m/z including the at least two product ions. The dissociation device receives a charge reducing reagent that causes the trapped at least two product ions to be charge reduced until their m/z values increase above the threshold m/z set by the AC voltage. The increase in the m/z values of the at least two product ions decreases their overlap. The at least two product ions with increased m/z values are transmitted to another device for subsequent mass analysis by applying the DC voltage to the dissociation device relative to a DC voltage applied to the other device.
    Type: Grant
    Filed: February 11, 2022
    Date of Patent: August 15, 2023
    Assignee: DH Technologies Development Pte.Ltd.
    Inventors: Takashi Baba, Pavel Ryumin, William M. Loyd
  • Patent number: 11728153
    Abstract: A multipole ion guide includes a plurality of electrodes disposed about a longitudinal axis of the device so as to define an ion transmission volume for transmitting ions along a length of the device between opposite inlet and outlet ends. An electronic controller is operably connected to an RF power source and to at least some of the electrodes and is configured to apply at least an RF potential to the electrodes. During use the electrodes generate an RF-only field along a first portion of the device and an axial DC field along a second portion of the device. Ions are focused radially inward toward the longitudinal axis of the device by the RF-only field within the first portion of the device prior to and/or subsequent to experiencing the axial DC field within the second portion of the device.
    Type: Grant
    Filed: December 14, 2018
    Date of Patent: August 15, 2023
    Assignee: Thermo Finnigan LLC
    Inventors: Paul I. Hendricks, Harald Oser
  • Patent number: 11728155
    Abstract: An ion optical arrangement (1) for use in a mass spectrometer comprises electrodes (11, 12, 14) comprising a multipole arrangement defining an ion optical axis, and a voltage source for providing voltages to the electrodes to produce electric fields. The ion optical arrangement is configured for producing a radio frequency electric focusing field for focusing ions on the ion optical axis. The radio frequency electric focusing field has a varying frequency so as to reduce any mass dependence of ion trajectories through the ion optical arrangement. The ion optical arrangement may further be configured for producing a static electric field in response to a DC bias voltage applied to the multipole arrangement. A superimposed varying electric field may be produced by superimposing an AC voltage upon the DC bias voltage.
    Type: Grant
    Filed: May 19, 2020
    Date of Patent: August 15, 2023
    Assignee: Thermo Fisher Scientific (Bremen) GmbH
    Inventors: Henning Wehrs, Johannes Schwieters, Gerhard Jung
  • Patent number: 11728147
    Abstract: The present invention centers upon a novel “molecular amplification spike,” which is an admixture of two components, namely, an aliquot of a quantity of a molecule, composition, compound or element of interest (an “analyte”) in its natural isotopic state and an aliquot of an isotopically enriched form of the same molecule, composition, compound or element. The molecular amplification spike contains 20% natural-abundance isotope, balance enriched isotope. The molecular amplification spike may optionally contain more than 20% natural-abundance isotope, with concomitantly reduced balance of enriched isotope. Such an admixed spike, when added to a sample prior to mass spectrometric analysis of that sample, creates new and significantly improved percentage of errors and quantification or confirmation of the absence of the molecule, composition, compound or element of interest in the sample.
    Type: Grant
    Filed: October 15, 2021
    Date of Patent: August 15, 2023
    Assignee: Definitek, Inc.
    Inventors: Mehmet Pamukcu, Howard M. Kingston