With Time-of-flight Indicator Patents (Class 250/287)
  • Patent number: 10964520
    Abstract: A multi-reflection mass spectrometer comprising two ion mirrors spaced apart and opposing each other in a direction X, each mirror elongated generally along a drift direction Y, the drift direction Y being orthogonal to the direction X, a pulsed ion injector for injecting pulses of ions into the space between the ion mirrors, the ions entering the space at a non-zero inclination angle to the X direction, the ions thereby forming an ion beam that follows a zigzag ion path having N reflections between the ion mirrors in the direction X whilst drifting along the drift direction Y, a detector for detecting ions after completing the same number N of reflections between the ion mirrors, and an ion focusing arrangement at least partly located between the opposing ion mirrors and configured to provide focusing of the ion beam in the drift direction Y, such that a spatial spread of the ion beam in the drift direction Y passes through a single minimum at or immediately after a reflection having a number between 0.
    Type: Grant
    Filed: November 27, 2019
    Date of Patent: March 30, 2021
    Assignee: Thermo Fisher Scientific (Bremen) GmbH
    Inventors: Hamish Stewart, Dmitry E. Grinfeld, Alexander A. Makarov
  • Patent number: 10964518
    Abstract: An apparatus for transporting charged particles. The apparatus includes a control unit and a transport device having a plurality of electrodes arranged around a transport channel, wherein the transport channel includes a bunch forming region configured to receive charged particles received by the transport device. The control unit is configured to control voltages applied to the electrodes to generate a transport potential in the transport channel, the transport potential having a plurality of potential wells which are configured to move so as to transport charged particles along the transport channel in one or more bunches.
    Type: Grant
    Filed: December 11, 2017
    Date of Patent: March 30, 2021
    Assignee: SHIMADZU CORPORATION
    Inventors: Matthew Gill, Roger Giles, Alina Giles
  • Patent number: 10942149
    Abstract: An ion sensor, an ion sensor manufacturing method, and a field asymmetric ion mobility spectrometry (FAIMS) system. The ion sensor includes an ion filter including a first electrode and a second electrode facing each other, an ion sensing electrode with which an ion that has passed through the ion filter collides, and an insulator to electrically insulate the ion sensing electrode from the first electrode and the second electrode. The method includes forming a first slit on an active layer of an at least one SOI substrate, the at least one SOI substrate including a base layer, an insulating layer on the base layer, and the active layer on the insulating layer, dividing the active layer into two, forming a second slit through the base layer, the second slit overlapping with the first slit in a planar view, and forming a third slit through the insulating layer.
    Type: Grant
    Filed: October 18, 2018
    Date of Patent: March 9, 2021
    Assignee: RICOH COMPANY, LTD.
    Inventors: Katsuya Ujimoto, Shinichi Kubota, Kunihiro Tan
  • Patent number: 10930484
    Abstract: To provide an ion detector having an electron lens structure that enables expansion of an effective region of an MCP for capturing ions. The ion detector comprises an MCP unit including an MCP and a first focus electrode, a signal output device including an electron detector surface, and a reset unit disposed between the MCP unit and the signal output device. The reset unit includes a reset element and a second focus electrode. The reset element includes a second input surface and a second output surface opposing each other. On the second output surface, the reset element resets variations in incident angle and velocity of electrons on the second input surface.
    Type: Grant
    Filed: March 30, 2020
    Date of Patent: February 23, 2021
    Assignee: HAMAMATSU PHOTONICS K.K.
    Inventors: Hiroshi Kobayashi, Shinya Hattori, Sayaka Takatsuka
  • Patent number: 10923337
    Abstract: An ion source of an ion trap mass spectrometer generates ions of a component in a sample. An ion trap captures the ions generated by the ion source. An ion detector detects ions ejected from the ion trap. A voltage application control part changes a voltage applied to the ion detector such that, after generation of ions by the ion source is started, ion detection capability of the ion detector during a time period when ions having a mass-to-charge ratio outside an analysis target range are ejected from the ion trap is lower as compared to ion detection capability of the ion detector during a time period when ions having a mass-to-charge ratio within the analysis target range are ejected from the ion trap.
    Type: Grant
    Filed: October 11, 2019
    Date of Patent: February 16, 2021
    Assignee: Shimadzu Corporation
    Inventor: Hideharu Shichi
  • Patent number: 10906320
    Abstract: A fluid ejection and circulation apparatus may include a fluid ejection die, the pressure regulator, a first standpipe, a second standpipe and a crossflow passage. The pressure regulator has a fluid chamber. The first standpipe is between the fluid chamber and the fluid ejection die. The first standpipe has a first port above the fluid ejection die. The second standpipe extends alongside the first standpipe. The second standpipe has a second port above the fluid ejection die. The crossflow passage connects the first standpipe and the second standpipe.
    Type: Grant
    Filed: April 30, 2019
    Date of Patent: February 2, 2021
    Assignee: Hewlett-Packard Development Company, L.P.
    Inventors: Benjamin H. Wood, Paul Mark Haines, Angela W. Bakkom, Anjan Prabhat Pattathil, Franklin D. Derryberry
  • Patent number: 10892151
    Abstract: A method of calibrating or optimising an analytical instrument is disclosed that comprises analysing analyte from a sample using an analytical instrument, determining a sample type of the sample based on analysis of analyte from the sample, identifying one or more species of the analyte that are known to be endogenous to the determined sample type, and calibrating or optimising the analytical instrument using the one or more identified endogenous species.
    Type: Grant
    Filed: June 1, 2016
    Date of Patent: January 12, 2021
    Assignee: Micromass UK Limited
    Inventors: Keith Richardson, Steven Derek Pringle, Michael Raymond Morris
  • Patent number: 10883964
    Abstract: An IMS ionizer comprising a wire, a second conductor, and a dielectric, when the first conductor and second conductor are energized to an ionization voltage, discharge ionization occurs. The dielectric is a glass element formed in a tubular shape defining an inner wall. The wire is formed in coils in contact with said inner wall. The second conductor is positioned to define an outer wall of the tube. The tube has an inlet end for receiving the sample, and an outlet end through which the sample exits after ionization.
    Type: Grant
    Filed: July 9, 2018
    Date of Patent: January 5, 2021
    Assignee: TEKNOSCAN SYSTEMS INC
    Inventor: Sabatino Nacson
  • Patent number: 10867780
    Abstract: The present invention can be directed to a mass spectrometer, relevant parts thereof like replacement kits or upgrading kits and/or mass spectrometry methods. A mass spectrometer according to the present invention can comprise at least one ion source for generating a beam of ions from a sample. Moreover at least one mass filter downstream of the ion source can be provided and adapted to select ions from the beam by their mass-to-charge ratio (m/z). Furthermore at least one collision cell arranged downstream of the mass filter can be arranged. At least one sector field mass analyser arranged downstream of the collision cell can be further provided and at least one ion multicollector comprising a plurality of ion detectors arranged downstream of the mass analyser, for detecting a plurality of different ion species in parallel and/or simultaneously.
    Type: Grant
    Filed: August 11, 2016
    Date of Patent: December 15, 2020
    Assignees: Thermo Fisher Scientific (Bremen) GmbH, The University of Bristol
    Inventors: Johannes Schwieters, Timothy Richard Elliott, Christopher David Coath
  • Patent number: 10852275
    Abstract: A method of ion mobility spectrometry is disclosed comprising: transmitting a plurality of ions to an ion mobility separator 6; modulating the introduction of the ions into the ion mobility separator 6 at a first modulation frequency; separating the ions that enter the ion mobility separator 6 according to ion mobility; detecting ions that have exited the ion mobility separator with a detector of a time of flight mass analyser 8; varying the first modulation frequency with time; recording the intensity of the ion signal output from the detector to produce recorded data; modulating the recorded data as a function of the time that the data was recorded and at a second modulation frequency, wherein the second modulation frequency is varied as a function of the time that the data was recorded; and determining, from the variation in intensity of the ion signal in the modulated data as a function of the second modulation frequency, the ion mobilities of the ions that have been detected.
    Type: Grant
    Filed: September 19, 2017
    Date of Patent: December 1, 2020
    Assignee: MICROMASS UK LIMITED
    Inventors: Keith George Richardson, Martin Raymond Green, David J. Langridge
  • Patent number: 10846605
    Abstract: An approach for detecting a transient error in a body fluid sample based on the shape of a response curve of a sensor is provided. The response curve is represented by an equation including at least one coefficient describing a curvature or slope of the response curve. The approach includes comparing the coefficient to a range of coefficients which includes coefficients of response curves corresponding to known analyte concentrations. The approach further includes detecting a transient error based on the comparison. In some examples of the approach, the comparison and detection are performed by a processing transient error detector executing computer readable instructions embodied in a non-transitory computer-readable medium. Other examples of the approach determine a concentration of the analyte based on the equation. Advantageously, various examples of the approach can expedite detection of transient errors at the time of measuring and before reporting sample result.
    Type: Grant
    Filed: January 22, 2018
    Date of Patent: November 24, 2020
    Assignee: Instrumentation Laboratory Company
    Inventors: Sohrab Mansouri, Jose Maria Cervera
  • Patent number: 10804090
    Abstract: A laser ablation cell (1) comprises a flow channel (11) having an essentially constant cross-sectional area so as to ensure a strictly laminar flow in the flow channel. A sample chamber (21) is provided adjacent to a lateral opening (14) of the flow channel. A laser beam (41) enters the sample chamber (21) through a lateral window (16) and impinges on a surface (24) of a sample (23) to ablate material from the sample. The sample may be positioned in such a distance from the flow channel that the laser-generated aerosol mass distribution has its center within the flow channel. This leads to short aerosol washout times. The laser ablation cell is particularly well suited for aerosol generation in inductively coupled plasma mass spectrometry (ICPMS), including imaging applications.
    Type: Grant
    Filed: April 25, 2019
    Date of Patent: October 13, 2020
    Assignees: ETH ZÜRICH, PAUL SCHERRER INSTITUT
    Inventors: Detlef Günther, Daniel Grolimund, Hao Wang
  • Patent number: 10741376
    Abstract: A method of time-of-flight mass spectrometry is disclosed comprising: providing two ion mirrors (42) that are spaced apart in a first dimension (X-dimension) and that are each elongated in a second dimension (Z-dimension) orthogonal to the first dimension; introducing packets of ions (47) into the space between the mirrors using an ion introduction mechanism (43) such that the ions repeatedly oscillate in the first dimension (X-dimension) between the mirrors (42) as they drift through said space in the second dimension (Z-dimension); oscillating the ions in a third dimension (Y-dimension) orthogonal to both the first and second dimensions as the ions drift through said space in the second dimension (Z-dimension); and receiving the ions in or on an ion receiving mechanism (44) after the ions have oscillated multiple times in the first dimension (X-dimension); wherein at least part of the ion introduction mechanism (43) and/or at least part of the ion receiving mechanism (44) is arranged between the mirrors (42
    Type: Grant
    Filed: April 29, 2016
    Date of Patent: August 11, 2020
    Assignee: MICROMASS UK LIMITED
    Inventors: John Brian Hoyes, Keith Richardson, Anatoly Verenchikov, Mikhail Yavor
  • Patent number: 10710194
    Abstract: A laser processing system includes a wavelength tunable laser apparatus capable of changing the wavelength of pulsed laser light to be outputted, an optical system irradiating a workpiece with the pulsed laser light, a reference wavelength acquisition section acquiring a reference wavelength corresponding to photon absorption according to the material of the workpiece, a laser processing controller controlling the wavelength tunable laser apparatus to perform preprocessing before final processing performed on the workpiece, changes the wavelength of the pulsed laser light over a predetermined range containing the reference wavelength, and performs wavelength search preprocessing at a plurality of wavelengths, a processed state measurer measuring a processed state on a wavelength basis achieved by the wavelength search preprocessing performed at the plurality of wavelengths, and an optimum wavelength determination section assessing the processed state on a wavelength basis to determine an optimum wavelength us
    Type: Grant
    Filed: June 3, 2019
    Date of Patent: July 14, 2020
    Assignee: Gigaphoton Inc.
    Inventors: Kouji Kakizaki, Osamu Wakabayashi
  • Patent number: 10699892
    Abstract: A voltage applied to an exit gate electrode forming a potential barrier and temporarily trapping ions within the inner space of the ion guide is higher than a voltage at an ion guide's exit end. A higher voltage is applied to the exit gate electrode for a lower m/z value of the measurement target ion, to push back the ion which has slowly moved along a potential gradient and reached the exit end of the ion guide. An ion having a lower m/z value is more likely to be located in a farther region from the exit end and forced to travel a longer distance when voltage applied to the exit gate electrode is lowered. A lower m/z value also means a higher travelling speed toward the orthogonal accelerator, whereby m/z dependency of the time required for travel from the ion guide to the orthogonal accelerator eventually becomes low.
    Type: Grant
    Filed: September 18, 2014
    Date of Patent: June 30, 2020
    Assignee: SHIMADZU CORPORATION
    Inventor: Daisuke Okumura
  • Patent number: 10658167
    Abstract: An ion source comprising a chamber and an electron collector is described. In one configuration, the chamber comprises a sample inlet and an ion outlet. The chamber may also include an electron inlet configured to receive electrons from an electron source. The electron collector can be arranged in opposition to the electron inlet. The chamber can be configured to direct an electron beam from the electron source along a path with the chamber transverse to a path between the gas inlet and the ion outlet. The chamber may comprise an ion guide that includes a guide axis offset from an axis of the ion outlet.
    Type: Grant
    Filed: September 29, 2018
    Date of Patent: May 19, 2020
    Assignee: PerkinElmer Health Sciences Canada, Inc.
    Inventors: Heather Gamble, Gholamreza Javahery, Lisa Cousins, Charles Jolliffe
  • Patent number: 10651024
    Abstract: An apparatus for detecting constituents in a sample includes first and second drift tubes defining first and second drift regions, and a controllable electric field device within a fragmentation region coupled to the first and second drift tubes. The apparatus also includes a first ion shutter positioned between the first drift and fragmentation regions. The apparatus further includes a control system configured to regulate the first ion shutter, thereby facilitating injection of a selected portion of ions from the first drift region into the fragmentation region. The control system is also configured to regulate the controllable device to modify the selected portion of ions to generate predetermined ion fragments within the fragmentation region, thereby facilitating injection of a selected portion of the predetermined fragmented ions into the second drift region. A method of detecting constituents in a sample is facilitated through such an apparatus.
    Type: Grant
    Filed: July 10, 2018
    Date of Patent: May 12, 2020
    Assignee: Rapiscan Systems, Inc.
    Inventors: Gary A. Eiceman, Stephen J. Davila, Stefan R. Lukow, Hartwig Schmidt
  • Patent number: 10641154
    Abstract: An aftertreatment system comprises a particulate filter configured to filter PM possessing a predetermined, least effective size range included in an exhaust gas flowing through the aftertreatment system. A PM sensor assembly is positioned downstream of the particulate filter and includes a housing having an inlet, an outlet, a sidewall and defines an internal volume. A PM sensor is positioned within the internal volume. The housing is configured to redirect a flow of exhaust gas entering the PM sensor assembly around the PM sensor so that small particles included in the exhaust gas flow having a first size within or smaller than the predetermined size range are directed around the particulate matter sensor. Large particles having a second size larger than the predetermined size range impact the PM sensor. A controller is communicatively coupled to the PM sensor.
    Type: Grant
    Filed: August 27, 2015
    Date of Patent: May 5, 2020
    Assignee: Cummins Emission Solutions Inc.
    Inventors: Christopher M. Cremeens, Aleksey Yezerets, Reshma Prattipati, Michael A. Robinson
  • Patent number: 10634599
    Abstract: A particle-measuring apparatus (1) for determining the particle mass concentration in aerosols having different properties has an aerosol photometer (2), by means of which a photometer measured value, which is dependent on the particle mass concentration in the aerosol, can be measured, and an evaluation unit (9), into which photometer measured values measured by the aerosol photometer (2) can be input and in which the input photometer measured values can be processed in order to output corrected particle mass concentration values.
    Type: Grant
    Filed: February 5, 2018
    Date of Patent: April 28, 2020
    Assignee: paragon GMBH & Co. KGaA
    Inventor: Ralf Moenkemoeller
  • Patent number: 10636646
    Abstract: An ion mirror is disclosed comprising an ion entrance electrode section (62) at the ion entrance to the ion mirror, an energy focussing electrode section (66) for reflecting ions back along a longitudinal axis towards said ion entrance, and a spatial focussing electrode section (64) arranged between the ion entrance electrode section (62) and the energy focussing electrode section (66) for spatially focussing the ions. One or more DC voltage supply is provided to apply a DC potential to the ion entrance electrode section (62) that is intermediate the DC potential applied to the spatial focussing electrode section (64) and the DC potential applied to the energy focussing electrode section (66).
    Type: Grant
    Filed: November 21, 2016
    Date of Patent: April 28, 2020
    Assignee: Micromass UK Limited
    Inventors: John Brian Hoyes, Anatoly Verenchikov, Mikhail Yavor, Keith Richardson
  • Patent number: 10636645
    Abstract: A mass analyzer includes two chambers for ionizing gas to form ions and/or introducing reaction gases to aid in ionization. A first chamber includes an electron to allow electron bombardment of a first gas. A second chamber receives a second gas and ions from the first chamber to allow interaction between the second gas, and the ions from the first chamber. The first and/or second gas may include analyte.
    Type: Grant
    Filed: April 20, 2018
    Date of Patent: April 28, 2020
    Assignee: PerkinElmer Health Sciences Canada, Inc.
    Inventors: Heather Gamble, Gholamreza Javahery, Lisa Cousins, Charles Jolliffe, Miles Snow
  • Patent number: 10629425
    Abstract: A time-of-flight mass spectrometer is disclosed comprising ion optics that map an array of ions at an ion source array (71) to a corresponding array of positions on a position sensitive ion detector (79). The ion optics include at least one gridless ion mirror (76) for reflecting ions, which may compensate for various aberrations and allows the spectrometer to have relatively high mass and spatial resolutions.
    Type: Grant
    Filed: November 16, 2016
    Date of Patent: April 21, 2020
    Assignees: MICROMASS UK LIMITED, LECO CORPORATION
    Inventors: John Brian Hoyes, Anatoly Verenchikov, Mikhail Yavor, Keith Richardson, Jason Wildgoose
  • Patent number: 10614992
    Abstract: Provided is a compact device which captures, over a large solid angle range, electrically charged particles emitted from a point source and parallelizes the trajectories of said charged particles. The present invention is configured from: an electrostatic lens comprising a plurality of axisymmetric electrodes (10-14) and an axisymmetric aspherical mesh (2) which has a surface that is concave away from the point source; and a flat collimator plate (3) positioned coaxially with the electrostatic lens. The acceptance angle for the electrically charged particles generated from a point source (7) is ±30° or greater. The shape of the aspherical mesh (2), and the potentials and the positions of a ground electrode (10) and application electrodes (11-15) are adjusted so that the trajectories of the electrically charged particles are substantially parallelized by the electrostatic lens. The electrostatic lens and the flat collimator plate are positioned on a common axis.
    Type: Grant
    Filed: July 13, 2016
    Date of Patent: April 7, 2020
    Assignee: National University Corporation Nara Institute of Science and Technology
    Inventors: Fumihiko Matsui, Hiroyuki Matsuda
  • Patent number: 10613055
    Abstract: In accordance with various aspects of the present teachings, methods and systems for differential mobility spectrometry are provided herein for simultaneously applying a plurality of SV/CV combinations to subsets of a population of ions generated by one or more ion sources. In various aspects, DMS devices in accordance with the present teachings can provide multiple channels (e.g., 2, 3, 4, 5, 6, or more) for operating in parallel and within which different electrical fields can be generated for filtering sample ions within those channels based on the characteristic mobilities of the ions within each channel. In this manner, devices and methods in accordance with the present teachings can, in various aspects, enable improved duty cycle, increased throughput, decreased sample consumption, increased sensitivity for a plurality of ions of interest, and/or increased resolution.
    Type: Grant
    Filed: March 15, 2017
    Date of Patent: April 7, 2020
    Assignee: DH Technologies Development Pte. Ltd.
    Inventors: Thomas Covey, Yang Kang, Chang Liu, Bradley Schneider
  • Patent number: 10598623
    Abstract: A conductivity cell system includes a flow tube having a flow through hole extending from a first end of the flow tube to a second end of the flow tube, a plurality of electrodes positioned in the flow tube, and circuitry connected to the plurality of electrodes. The plurality of electrodes form pairs of electrodes, each pair consisting of two electrodes positioned across the flow tube from each other and being connected together.
    Type: Grant
    Filed: May 24, 2017
    Date of Patent: March 24, 2020
    Assignee: Rosemount Aerospace Inc.
    Inventors: Tomas Lorincz, Rudy Pitera, Thomas Lenagh
  • Patent number: 10600630
    Abstract: A method of mass spectrometry is disclosed comprising passing ions to an oversampled Time of Flight mass analyser (4) and sequentially recording ion signals on a plurality of different channels (51, 52) to obtain a plurality of first oversampled mass spectral data sets of reduced complexity. An upstream separation device (3) may be provided to further reduce the complexity of each of the mass spectral data sets.
    Type: Grant
    Filed: May 6, 2016
    Date of Patent: March 24, 2020
    Assignee: Micromass UK Limited
    Inventors: John Brian Hoyes, Richard Denny, Jason Lee Wildgoose, Peter Nixon
  • Patent number: 10551347
    Abstract: A method of mass spectrometry is disclosed comprising isolating a group of different ions derived from chemical compounds in the same class, wherein the different ions have different mass to charge ratios and ion mobilities. The step of isolating comprises temporally separating the ions according to their ion mobility in an ion mobility separator; and mass filtering the ions according to mass to charge ratio with a mass filter. The mass to charge ratios transmitted by the mass filter are varied as a function of time such that said different ions derived from chemical compounds in the same class are transmitted by the mass filter and other ions are not transmitted by the mass filter.
    Type: Grant
    Filed: November 11, 2014
    Date of Patent: February 4, 2020
    Assignee: MICROMASS UK LIMITED
    Inventors: John Brian Hoyes, Steven Derek Pringle, Farnoush Salarzaei, Jason Lee Wildgoose
  • Patent number: 10541123
    Abstract: An apparatus 41 and operation method are provided for an electrostatic trap mass spectrometer with measuring frequency of multiple isochronous ionic oscillations. For improving throughput and space charge capacity, the trap is substantially extended in one Z-direction forming a reproduced two-dimensional field. Multiple geometries are provided for trap Z-extension. The throughput of the analysis is improved by multiplexing electrostatic traps. The frequency analysis is accelerated by the shortening of ion packets and either by Wavelet-fit analysis of the image current signal or by using a time-of-flight detector for sampling a small portion of ions per oscillation. Multiple pulsed converters are suggested for optimal ion injection into electrostatic traps.
    Type: Grant
    Filed: June 7, 2019
    Date of Patent: January 21, 2020
    Assignee: LECO Corporation
    Inventor: Anatoly N. Verenchikov
  • Patent number: 10535509
    Abstract: The present disclosure provides an ion migration tube and a method of operation the same. The ion migration tube includes an interior space and an ion gate disposed within the interior space, the interior space includes an ionization region having an absolute value of potential V1 and a migration region. An ion gate is disposed between the ionization region and the migration region and includes a first ion gate grid having an absolute value of potential V2 and a second ion gate grid having an absolute value of potential V3, the migration region comprises at least a first migration region electrode having an absolute value of potential V4 and a second migration region electrode having an absolute value of potential V5. When the ion gate is opened, a potential well is formed for ionized ions between the first ion gate grid and the first migration region electrode so as to compress an ion group entering the migration region.
    Type: Grant
    Filed: December 29, 2017
    Date of Patent: January 14, 2020
    Assignees: Nuctech Company Limited, Tsinghua University
    Inventors: Qingjun Zhang, Yuanjing Li, Ziran Zhao, Weiping Zhu, Huishao He, Xianghua Li, Qiufeng Ma
  • Patent number: 10527728
    Abstract: An apparatus and a method. The apparatus includes a single-photon avalanche diode (SPAD) circuit configured to detect a photon, including a first input for receiving a first voltage (VSPAD), a second input for receiving a first signal (SHUTTER), a third input for receiving a second voltage (VDD), and an output; a logic circuit configured to latch the detected photon, including a first input connected to the output of the SPAD circuit, a second input for receiving a second signal (TXRMD), and an output; and a pinned photo diode (PPD) circuit configured to record a time of flight (TOF) of the detected photon, including a first input connected to the output of the logic circuit, a second input for receiving a third signal (VTX), a third input for receiving a fourth signal (RST), a fourth input for receiving a third voltage (VPIX), a fifth input for receiving a fifth signal (SEL), and an output.
    Type: Grant
    Filed: April 26, 2017
    Date of Patent: January 7, 2020
    Assignee: Samsung Electronics Co., Ltd
    Inventor: Yibing Michelle Wang
  • Patent number: 10438788
    Abstract: A system for expressing an ion path in a time-of-flight (TOF) mass spectrometer. The present invention uses two successive curved sectors, with the second one reversed, to form S-shaped configuration such that an output ion beam is parallel to an input ion beam, such that the ions makes two identical but opposed turns, and such that the geometry of the entire system folds into a very compact volume. Geometry of a TOF mass spectrometer system in accordance with embodiments of the present invention further includes straight drift regions positioned before and after the S-shaped configuration and, optionally, a short straight region positioned between the two curved sectors with total length equal to about the length of the central arc of both curved sectors.
    Type: Grant
    Filed: November 12, 2018
    Date of Patent: October 8, 2019
    Assignee: NOAA Technology Partnerships Office
    Inventor: Daniel Murphy
  • Patent number: 10420957
    Abstract: A method for creating a first data set for modifying an irradiation plan parameter data set used for controlling an irradiation system for irradiating a target volume in an irradiation volume using an ion beam includes defining a sensitive volume within the biological material to be irradiated, determining a fluence distribution of the ion beam, determining a microscopic dose distribution of the ion beam, determining, from the microscopic dose distribution of the ion beam, a spatial microscopic damage distribution of the ion beam, determining an expected value for a number of correlated damage events in a sub-micrometer range in the sensitive volume from the spatial microscopic damage distribution of the ion beam in the sensitive volume, determining the effect of the ion beam on the biological material, and storing data that indicate the effect of the ion beam on the material.
    Type: Grant
    Filed: October 24, 2016
    Date of Patent: September 24, 2019
    Assignee: GSI HELMHOLTZZENTRUM FUER SCHWERIONENFORSCHUNG GMBH
    Inventors: Michael Scholz, Thilo Elsaesser
  • Patent number: 10403486
    Abstract: A data acquisition system for a TOF mass spectrometer comprises a processing module and a data collection module. The processing module generates a stream of data comprising, for each respective transient of a first scan, a set of time-intensity related parameter pairs. For each new set of data, the data collection module reads out a previous set of data from a previous memory bank, merges that previous set of data with the new set of data, and writes that latest merged set of data into a memory bank other than the previous memory bank. The data acquisition system provides a convenient way to merge sequential sets of time-intensity related parameter pairs for respective transients as a stream of data for a first scan is generated.
    Type: Grant
    Filed: August 18, 2016
    Date of Patent: September 3, 2019
    Assignee: MICROMASS UK LIMITED
    Inventors: Garry Michael Scott, David Darrell Williams, Peter Gerard Spreadbury, Martin Raymond Green, Anthony James Gilbert, Keith George Richardson, Jason Lee Wildgoose
  • Patent number: 10381206
    Abstract: A hybrid mass spectrometer comprising: an ion source for generating ions from a sample, a first mass spectral system comprising a nanoelectromechanical mass spectral (NEMS-MS) system, a second mass spectral system including at least one mass analyzer adapted to separate the charged particles according to their mass-to-charge ratios, and an integration zone coupling the first and second mass spectral systems, the integration zone including at least one directional device for controllably routing the ions to a selected one or both of the first and second mass spectral systems for analysis thereby. The second system can be an orbital electrostatic trap system. The ion beam can be electrically directed to one or the other system by ion optics. A chip with resonators can be used with cooling. Uses include analysis of large mass complexes found in biological systems, native single molecule analysis, and size and shape analysis.
    Type: Grant
    Filed: January 22, 2016
    Date of Patent: August 13, 2019
    Assignees: California Institute of Technology, Thermo Fisher Scientific (Bremen) GmbH
    Inventors: Michael L. Roukes, Alexander A. Makarov
  • Patent number: 10373817
    Abstract: A method of determining the structure of a macromolecular assembly (MMA) comprises the steps of (a) generating precursor ions of an MMA species to be investigated; (b) transporting the MMA precursor ions to a fragmentation zone; (c) carrying out pulsed fragmentation of the MMA precursor ions in the fragmentation zone; (d) for a first plurality of MMA precursor ions, detecting both a spatial distribution of the resultant MMA fragment ions, and an m/z distribution of the MMA fragment ions; (e) analyzing the spatial and m/z distributions of fragment ions formed from the said first plurality of precursor ions of the MMA species to be investigated, to determine the relative positions of those fragment ions within the structure of the precursor MMA; and (f) reconstructing the three dimensional (3D) structure of the MMA from the analysis of the spatial and m/z distributions of fragment ions.
    Type: Grant
    Filed: July 23, 2018
    Date of Patent: August 6, 2019
    Assignees: Thermo Fisher Scientific (Bremen) GmbH, Universiteit Maastricht, Universiteit Ultrecht Holding B.V.
    Inventors: Alexander Alekseevich Makarov, Ronald M. A. Heeren, Albert J. R. Heck
  • Patent number: 10373815
    Abstract: A method of validating data produced from a multiplexing process on an analytical instrument is disclosed. In one embodiment, the method includes using a pseudorandom sequence to encode a multiplexed segment of data; applying Hadamard transform to generate a demultiplexed segment of the data; aligning the pseudorandom sequence to the multiplexed data; and calculating a score for at least one positive value in the demultiplexed segment to find a valid demultiplexed value.
    Type: Grant
    Filed: March 5, 2014
    Date of Patent: August 6, 2019
    Assignee: Battelle Memorial Institute
    Inventors: Kevin L. Crowell, Spencer A. Prost
  • Patent number: 10354851
    Abstract: A secondary ion mass spectrometer comprises: (a) a first primary ion source for generating a first pulsed primary ion beam with short pulse durations; (b) a second primary ion source for generating a second pulsed primary ion beam with pulse durations in the range of 50 ns and up to 5 s; (c) a first TOF-SIMS analysis unit for mass spectroscopic analysis of the secondary ions generated by the primary ion pulses of the first primary ion source from a sample; and (d) a second analysis unit for mass spectroscopic analysis of the secondary ions generated by the primary ion pulses of the second primary ion source from a sample.
    Type: Grant
    Filed: September 8, 2016
    Date of Patent: July 16, 2019
    Assignee: IONTOF TECHNOLOGIES GmbH
    Inventors: Rudolf Moellers, Ewald Niehuis
  • Patent number: 10354849
    Abstract: A method of mass spectrometry is disclosed comprising digitizing a plurality of individual signals or transients and summing the plurality of digitized signals or transients or data relating to the plurality of digitized signals or transients to generate a composite mass spectral data set. The method further comprises determining in relation to the composite mass spectral data set an indication of the proportion of instances that intensity values relating to the individual digitized signals or transients either: (i) exceeded or approached a threshold value; (ii) suffered from saturation or approached saturation; or (iii) resulted from the dynamic range of an ion detector system being exceeded or approached.
    Type: Grant
    Filed: July 9, 2014
    Date of Patent: July 16, 2019
    Assignee: MICROMASS UK LIMITED
    Inventors: Richard Denny, Anthony James Gilbert, Martin Raymond Green, Steven Derek Pringle, Garry Michael Scott, Jason Lee Wildgoose
  • Patent number: 10340132
    Abstract: Improvements to a side-on Penning trap include a feedback system for stabilizing the magnetic field. This system includes a magnetic sensor that measures the magnetic field and a solenoid coil that in response to the magnetic field measurements increases or decreases the overall magnetic field. Improvements also include a number of different configurations of the two sets of PCB electrodes used to produce the quadrupole electric field. Dimensions of the PCB electrodes are optimized, an equipotential surface electrode is added, and additional ring electrodes are added to produce a purer quadrupole field. A central disk electrode is segmented to direct charged particles to the trap center to make the trap useful for applications other than mass spectrometry. Finally, outer ring electrodes are segmented to increase the path of charged particles, thereby increasing sensitivity.
    Type: Grant
    Filed: November 24, 2016
    Date of Patent: July 2, 2019
    Assignee: DH Technologies Development Pte. Ltd.
    Inventor: Takashi Baba
  • Patent number: 10319577
    Abstract: A mass spectrometer is disclosed comprising an ion mobility spectrometer and an ion gate. A collision cell is arranged downstream of the ion gate. The operation of the ion mobility spectrometer and the ion gate are synchronized so that only ions having a particular mass to charge ration and a desired charge state are onwardly transmitted to the collision cell.
    Type: Grant
    Filed: June 19, 2017
    Date of Patent: June 11, 2019
    Assignee: MICROMASS UK LIMITED
    Inventors: Robert Harold Bateman, Kevin Giles, Steven Derek Pringle, Jason Lee Wildgoose
  • Patent number: 10309930
    Abstract: Systems and methods are provided for providing a DMS precursor ion survey scan. An ion source configured to receive a sample is instructed to ionize the sample using a processor. A DMS device configured to receive ions from the ion source is instructed to separate precursor ions received from the ion source and transmit precursor ions using two or more CoVs using the processor. A mass analyzer configured to receive transmitted precursor ions from the DMS device is instructed to measure the m/z intensities of the transmitted precursor ions across an m/z range at each CoV of the two or more CoVs using the processor. The measured m/z intensities of the transmitted precursor ions received from the mass analyzer are stored as a function of m/z value and CoV using the processor. This produces a stored two-dimensional mapping of m/z intensities of the precursor ions of the sample.
    Type: Grant
    Filed: September 21, 2015
    Date of Patent: June 4, 2019
    Assignee: DH Technologies Development Pte. Ltd.
    Inventors: John Lawrence Campbell, Eva Duchoslav, Yves Le Blanc, David M. Cox
  • Patent number: 10304673
    Abstract: An ion guide comprises a first ion guide portion that forms a first ion guiding path and a second ion guide portion that forms a second ion guiding path. A first device applies a plurality of different first voltages or potentials to the electrodes of the first ion guide portion in order to generate an electric field that directs ions from the first ion guiding path of the first ion guide portion into the second ion guiding path of the second ion guide portion. The use of plural different first voltages can provide a controlled transfer of ions from the first ion guiding path into the second ion guiding path.
    Type: Grant
    Filed: September 28, 2016
    Date of Patent: May 28, 2019
    Assignee: MICROMASS UK LIMITED
    Inventors: Kevin Giles, David Gordon
  • Patent number: 10290482
    Abstract: A tandem collision/reaction cell for an inductively coupled plasma-mass spectrometry (ICP-MS) system includes a first ion guide, a second ion guide, and an intermediate electrode in the vicinity of an exit end of the first ion guide. A DC potential barrier is applied to the intermediate electrode. The cell may provide two or more stages of an ion-molecule collision process.
    Type: Grant
    Filed: March 13, 2018
    Date of Patent: May 14, 2019
    Assignee: Agilent Technologies, Inc.
    Inventors: Noriyuki Yamada, Erina Shimizu, Yu Okamoto
  • Patent number: 10290480
    Abstract: Apparatus and methods are disclosed for processing data transformed according to an invertible transform (e.g., using a Hadamard transform) multiplexing scheme. In one example of the disclosed technology, a computer-implemented method includes generating transformed data by applying a Hadamard transform to intensity data generated by modulating input of analytes into a mass spectrometer according to a pseudorandom sequence (PRS). The exemplary method further includes identifying at least one pair of symmetric intensity peaks in the transformed data based on the PRS and removing data associated with the pair of symmetric peaks from the transformed data to produce modified data, which can be used to identify, characterize, and/or quantify the composition of the sample. In some examples, the exemplary method further includes validating peaks in the transformed data based on comparing the location of peaks in the untransformed intensity data.
    Type: Grant
    Filed: April 19, 2013
    Date of Patent: May 14, 2019
    Assignee: Battelle Memorial Institute
    Inventors: Kevin Crowell, Spencer A. Prost
  • Patent number: 10262848
    Abstract: In a device adjustment process, when a solenoid valve is opened, a gas resulting from vaporization of PFTBA held in a container is drawn into an ion source, a relationship between ambient temperature and a correction coefficient for actual signal values is experimentally determined beforehand. In an actual adjustment process, an ambient temperature acquirer reads the ambient temperature and refers to the correction information to determine the correction coefficient corresponding to the ambient temperature at that moment. A signal value corrector multiplies an actually measured peak area value by the correction coefficient to correct the actual signal value. A device adjustment controller adjusts a voltage applied to an ion detector so that the corrected actual signal value matches with a reference signal value. The voltage applied to the ion detector can be thereby adjusted so that the detector has the same level of gain independent of the ambient temperature.
    Type: Grant
    Filed: January 21, 2015
    Date of Patent: April 16, 2019
    Assignee: SHIMADZU CORPORATION
    Inventor: Manabu Shimomura
  • Patent number: 10254247
    Abstract: Method and systems for managing clear-down are provided. The method can include generating a clear-down trigger associated with an ion mobility spectrometer and operating the ion mobility spectrometer in fast clear-down mode in response to the clear-down trigger. Methods and systems can further provide that where the ion mobility spectrometer operates in fast-switching mode, the ion mobility spectrometer alternating a plurality of times between operation according to a positive ion mode and operation according to a negative ion mode, and further operating according to the positive ion mode for less than about 1 second before switching to the operation according to the negative ion mode, and operating according to the negative ion mode for less than about 1 second before switching to the operation according to the positive ion mode.
    Type: Grant
    Filed: October 27, 2011
    Date of Patent: April 9, 2019
    Assignee: SMITHS DETECTION MONTREAL INC.
    Inventors: Qunzhou Bian, John J. Carroll
  • Patent number: 10241106
    Abstract: There is no small ion detecting apparatus that quickly and easily performs mass spectrometry under atmospheric pressure. Therefore, in order to solve the problem, an electrode arrangement and an electrode holding form for enabling water clusters in outside air to be detected with high sensitivity are provided. By using such solving means, it is possible to detect ions in a place having spatial constraints.
    Type: Grant
    Filed: May 27, 2013
    Date of Patent: March 26, 2019
    Assignee: Hitachi, Ltd.
    Inventor: Minoru Sakairi
  • Patent number: 10241079
    Abstract: The invention proposes a mass spectrometer comprising two ion mobility analyzers in tandem arrangement, of which at least one is a trapped ion mobility spectrometer (TIMS), and an ion gate which is located between the two ion mobility analyzers, and use thereof wherein ions are selectively transferred between the two ion mobility analyzers by adjusting the transmission of the ion gate while ions are separated in time according to ion mobility in the first ion mobility analyzer.
    Type: Grant
    Filed: May 24, 2017
    Date of Patent: March 26, 2019
    Inventors: Thomas Betz, Melvin Andrew Park, Mark Ridgeway
  • Patent number: 10209188
    Abstract: Exemplary methods and systems for incorporating bio-sensors in drones to wirelessly detect biological molecules and hazards without exposing an operator to harmful contaminants or conditions. Bio-sensors can incorporate simultaneous dual-detection methods to ensure accuracy of measurements. Methods of operation include registering blank and safe air profiles for comparison against unknown air profiles to accurately determine the presence of bio-contaminants in unknown air.
    Type: Grant
    Filed: November 1, 2017
    Date of Patent: February 19, 2019
    Assignee: The United States of America, as represented by the Secretary of the Navy
    Inventors: Kin Chiu Ng, Subrata Sanyal
  • Patent number: 10204774
    Abstract: Instruments are disclosed for analyzing ions from about 1000 to 10,000,000 Daltons by controlling a gaseous medium through which the ions travel under the influence of an electric field so that properties of the ions, such as diameter, electrical mobility, and charge, are measured. One embodiment of the disclosed instruments includes an ion source, a nozzle, a jet relaxation region, an ion accumulation region, an electronic gate, a flow chamber and an ion detector.
    Type: Grant
    Filed: May 29, 2017
    Date of Patent: February 12, 2019
    Inventor: W. Henry Benner