With Time-of-flight Indicator Patents (Class 250/287)
  • Patent number: 10535509
    Abstract: The present disclosure provides an ion migration tube and a method of operation the same. The ion migration tube includes an interior space and an ion gate disposed within the interior space, the interior space includes an ionization region having an absolute value of potential V1 and a migration region. An ion gate is disposed between the ionization region and the migration region and includes a first ion gate grid having an absolute value of potential V2 and a second ion gate grid having an absolute value of potential V3, the migration region comprises at least a first migration region electrode having an absolute value of potential V4 and a second migration region electrode having an absolute value of potential V5. When the ion gate is opened, a potential well is formed for ionized ions between the first ion gate grid and the first migration region electrode so as to compress an ion group entering the migration region.
    Type: Grant
    Filed: December 29, 2017
    Date of Patent: January 14, 2020
    Assignees: Nuctech Company Limited, Tsinghua University
    Inventors: Qingjun Zhang, Yuanjing Li, Ziran Zhao, Weiping Zhu, Huishao He, Xianghua Li, Qiufeng Ma
  • Patent number: 10527728
    Abstract: An apparatus and a method. The apparatus includes a single-photon avalanche diode (SPAD) circuit configured to detect a photon, including a first input for receiving a first voltage (VSPAD), a second input for receiving a first signal (SHUTTER), a third input for receiving a second voltage (VDD), and an output; a logic circuit configured to latch the detected photon, including a first input connected to the output of the SPAD circuit, a second input for receiving a second signal (TXRMD), and an output; and a pinned photo diode (PPD) circuit configured to record a time of flight (TOF) of the detected photon, including a first input connected to the output of the logic circuit, a second input for receiving a third signal (VTX), a third input for receiving a fourth signal (RST), a fourth input for receiving a third voltage (VPIX), a fifth input for receiving a fifth signal (SEL), and an output.
    Type: Grant
    Filed: April 26, 2017
    Date of Patent: January 7, 2020
    Assignee: Samsung Electronics Co., Ltd
    Inventor: Yibing Michelle Wang
  • Patent number: 10438788
    Abstract: A system for expressing an ion path in a time-of-flight (TOF) mass spectrometer. The present invention uses two successive curved sectors, with the second one reversed, to form S-shaped configuration such that an output ion beam is parallel to an input ion beam, such that the ions makes two identical but opposed turns, and such that the geometry of the entire system folds into a very compact volume. Geometry of a TOF mass spectrometer system in accordance with embodiments of the present invention further includes straight drift regions positioned before and after the S-shaped configuration and, optionally, a short straight region positioned between the two curved sectors with total length equal to about the length of the central arc of both curved sectors.
    Type: Grant
    Filed: November 12, 2018
    Date of Patent: October 8, 2019
    Assignee: NOAA Technology Partnerships Office
    Inventor: Daniel Murphy
  • Patent number: 10420957
    Abstract: A method for creating a first data set for modifying an irradiation plan parameter data set used for controlling an irradiation system for irradiating a target volume in an irradiation volume using an ion beam includes defining a sensitive volume within the biological material to be irradiated, determining a fluence distribution of the ion beam, determining a microscopic dose distribution of the ion beam, determining, from the microscopic dose distribution of the ion beam, a spatial microscopic damage distribution of the ion beam, determining an expected value for a number of correlated damage events in a sub-micrometer range in the sensitive volume from the spatial microscopic damage distribution of the ion beam in the sensitive volume, determining the effect of the ion beam on the biological material, and storing data that indicate the effect of the ion beam on the material.
    Type: Grant
    Filed: October 24, 2016
    Date of Patent: September 24, 2019
    Assignee: GSI HELMHOLTZZENTRUM FUER SCHWERIONENFORSCHUNG GMBH
    Inventors: Michael Scholz, Thilo Elsaesser
  • Patent number: 10403486
    Abstract: A data acquisition system for a TOF mass spectrometer comprises a processing module and a data collection module. The processing module generates a stream of data comprising, for each respective transient of a first scan, a set of time-intensity related parameter pairs. For each new set of data, the data collection module reads out a previous set of data from a previous memory bank, merges that previous set of data with the new set of data, and writes that latest merged set of data into a memory bank other than the previous memory bank. The data acquisition system provides a convenient way to merge sequential sets of time-intensity related parameter pairs for respective transients as a stream of data for a first scan is generated.
    Type: Grant
    Filed: August 18, 2016
    Date of Patent: September 3, 2019
    Assignee: MICROMASS UK LIMITED
    Inventors: Garry Michael Scott, David Darrell Williams, Peter Gerard Spreadbury, Martin Raymond Green, Anthony James Gilbert, Keith George Richardson, Jason Lee Wildgoose
  • Patent number: 10381206
    Abstract: A hybrid mass spectrometer comprising: an ion source for generating ions from a sample, a first mass spectral system comprising a nanoelectromechanical mass spectral (NEMS-MS) system, a second mass spectral system including at least one mass analyzer adapted to separate the charged particles according to their mass-to-charge ratios, and an integration zone coupling the first and second mass spectral systems, the integration zone including at least one directional device for controllably routing the ions to a selected one or both of the first and second mass spectral systems for analysis thereby. The second system can be an orbital electrostatic trap system. The ion beam can be electrically directed to one or the other system by ion optics. A chip with resonators can be used with cooling. Uses include analysis of large mass complexes found in biological systems, native single molecule analysis, and size and shape analysis.
    Type: Grant
    Filed: January 22, 2016
    Date of Patent: August 13, 2019
    Assignees: California Institute of Technology, Thermo Fisher Scientific (Bremen) GmbH
    Inventors: Michael L. Roukes, Alexander A. Makarov
  • Patent number: 10373815
    Abstract: A method of validating data produced from a multiplexing process on an analytical instrument is disclosed. In one embodiment, the method includes using a pseudorandom sequence to encode a multiplexed segment of data; applying Hadamard transform to generate a demultiplexed segment of the data; aligning the pseudorandom sequence to the multiplexed data; and calculating a score for at least one positive value in the demultiplexed segment to find a valid demultiplexed value.
    Type: Grant
    Filed: March 5, 2014
    Date of Patent: August 6, 2019
    Assignee: Battelle Memorial Institute
    Inventors: Kevin L. Crowell, Spencer A. Prost
  • Patent number: 10373817
    Abstract: A method of determining the structure of a macromolecular assembly (MMA) comprises the steps of (a) generating precursor ions of an MMA species to be investigated; (b) transporting the MMA precursor ions to a fragmentation zone; (c) carrying out pulsed fragmentation of the MMA precursor ions in the fragmentation zone; (d) for a first plurality of MMA precursor ions, detecting both a spatial distribution of the resultant MMA fragment ions, and an m/z distribution of the MMA fragment ions; (e) analyzing the spatial and m/z distributions of fragment ions formed from the said first plurality of precursor ions of the MMA species to be investigated, to determine the relative positions of those fragment ions within the structure of the precursor MMA; and (f) reconstructing the three dimensional (3D) structure of the MMA from the analysis of the spatial and m/z distributions of fragment ions.
    Type: Grant
    Filed: July 23, 2018
    Date of Patent: August 6, 2019
    Assignees: Thermo Fisher Scientific (Bremen) GmbH, Universiteit Maastricht, Universiteit Ultrecht Holding B.V.
    Inventors: Alexander Alekseevich Makarov, Ronald M. A. Heeren, Albert J. R. Heck
  • Patent number: 10354849
    Abstract: A method of mass spectrometry is disclosed comprising digitizing a plurality of individual signals or transients and summing the plurality of digitized signals or transients or data relating to the plurality of digitized signals or transients to generate a composite mass spectral data set. The method further comprises determining in relation to the composite mass spectral data set an indication of the proportion of instances that intensity values relating to the individual digitized signals or transients either: (i) exceeded or approached a threshold value; (ii) suffered from saturation or approached saturation; or (iii) resulted from the dynamic range of an ion detector system being exceeded or approached.
    Type: Grant
    Filed: July 9, 2014
    Date of Patent: July 16, 2019
    Assignee: MICROMASS UK LIMITED
    Inventors: Richard Denny, Anthony James Gilbert, Martin Raymond Green, Steven Derek Pringle, Garry Michael Scott, Jason Lee Wildgoose
  • Patent number: 10354851
    Abstract: A secondary ion mass spectrometer comprises: (a) a first primary ion source for generating a first pulsed primary ion beam with short pulse durations; (b) a second primary ion source for generating a second pulsed primary ion beam with pulse durations in the range of 50 ns and up to 5 s; (c) a first TOF-SIMS analysis unit for mass spectroscopic analysis of the secondary ions generated by the primary ion pulses of the first primary ion source from a sample; and (d) a second analysis unit for mass spectroscopic analysis of the secondary ions generated by the primary ion pulses of the second primary ion source from a sample.
    Type: Grant
    Filed: September 8, 2016
    Date of Patent: July 16, 2019
    Assignee: IONTOF TECHNOLOGIES GmbH
    Inventors: Rudolf Moellers, Ewald Niehuis
  • Patent number: 10340132
    Abstract: Improvements to a side-on Penning trap include a feedback system for stabilizing the magnetic field. This system includes a magnetic sensor that measures the magnetic field and a solenoid coil that in response to the magnetic field measurements increases or decreases the overall magnetic field. Improvements also include a number of different configurations of the two sets of PCB electrodes used to produce the quadrupole electric field. Dimensions of the PCB electrodes are optimized, an equipotential surface electrode is added, and additional ring electrodes are added to produce a purer quadrupole field. A central disk electrode is segmented to direct charged particles to the trap center to make the trap useful for applications other than mass spectrometry. Finally, outer ring electrodes are segmented to increase the path of charged particles, thereby increasing sensitivity.
    Type: Grant
    Filed: November 24, 2016
    Date of Patent: July 2, 2019
    Assignee: DH Technologies Development Pte. Ltd.
    Inventor: Takashi Baba
  • Patent number: 10319577
    Abstract: A mass spectrometer is disclosed comprising an ion mobility spectrometer and an ion gate. A collision cell is arranged downstream of the ion gate. The operation of the ion mobility spectrometer and the ion gate are synchronized so that only ions having a particular mass to charge ration and a desired charge state are onwardly transmitted to the collision cell.
    Type: Grant
    Filed: June 19, 2017
    Date of Patent: June 11, 2019
    Assignee: MICROMASS UK LIMITED
    Inventors: Robert Harold Bateman, Kevin Giles, Steven Derek Pringle, Jason Lee Wildgoose
  • Patent number: 10309930
    Abstract: Systems and methods are provided for providing a DMS precursor ion survey scan. An ion source configured to receive a sample is instructed to ionize the sample using a processor. A DMS device configured to receive ions from the ion source is instructed to separate precursor ions received from the ion source and transmit precursor ions using two or more CoVs using the processor. A mass analyzer configured to receive transmitted precursor ions from the DMS device is instructed to measure the m/z intensities of the transmitted precursor ions across an m/z range at each CoV of the two or more CoVs using the processor. The measured m/z intensities of the transmitted precursor ions received from the mass analyzer are stored as a function of m/z value and CoV using the processor. This produces a stored two-dimensional mapping of m/z intensities of the precursor ions of the sample.
    Type: Grant
    Filed: September 21, 2015
    Date of Patent: June 4, 2019
    Assignee: DH Technologies Development Pte. Ltd.
    Inventors: John Lawrence Campbell, Eva Duchoslav, Yves Le Blanc, David M. Cox
  • Patent number: 10304673
    Abstract: An ion guide comprises a first ion guide portion that forms a first ion guiding path and a second ion guide portion that forms a second ion guiding path. A first device applies a plurality of different first voltages or potentials to the electrodes of the first ion guide portion in order to generate an electric field that directs ions from the first ion guiding path of the first ion guide portion into the second ion guiding path of the second ion guide portion. The use of plural different first voltages can provide a controlled transfer of ions from the first ion guiding path into the second ion guiding path.
    Type: Grant
    Filed: September 28, 2016
    Date of Patent: May 28, 2019
    Assignee: MICROMASS UK LIMITED
    Inventors: Kevin Giles, David Gordon
  • Patent number: 10290482
    Abstract: A tandem collision/reaction cell for an inductively coupled plasma-mass spectrometry (ICP-MS) system includes a first ion guide, a second ion guide, and an intermediate electrode in the vicinity of an exit end of the first ion guide. A DC potential barrier is applied to the intermediate electrode. The cell may provide two or more stages of an ion-molecule collision process.
    Type: Grant
    Filed: March 13, 2018
    Date of Patent: May 14, 2019
    Assignee: Agilent Technologies, Inc.
    Inventors: Noriyuki Yamada, Erina Shimizu, Yu Okamoto
  • Patent number: 10290480
    Abstract: Apparatus and methods are disclosed for processing data transformed according to an invertible transform (e.g., using a Hadamard transform) multiplexing scheme. In one example of the disclosed technology, a computer-implemented method includes generating transformed data by applying a Hadamard transform to intensity data generated by modulating input of analytes into a mass spectrometer according to a pseudorandom sequence (PRS). The exemplary method further includes identifying at least one pair of symmetric intensity peaks in the transformed data based on the PRS and removing data associated with the pair of symmetric peaks from the transformed data to produce modified data, which can be used to identify, characterize, and/or quantify the composition of the sample. In some examples, the exemplary method further includes validating peaks in the transformed data based on comparing the location of peaks in the untransformed intensity data.
    Type: Grant
    Filed: April 19, 2013
    Date of Patent: May 14, 2019
    Assignee: Battelle Memorial Institute
    Inventors: Kevin Crowell, Spencer A. Prost
  • Patent number: 10262848
    Abstract: In a device adjustment process, when a solenoid valve is opened, a gas resulting from vaporization of PFTBA held in a container is drawn into an ion source, a relationship between ambient temperature and a correction coefficient for actual signal values is experimentally determined beforehand. In an actual adjustment process, an ambient temperature acquirer reads the ambient temperature and refers to the correction information to determine the correction coefficient corresponding to the ambient temperature at that moment. A signal value corrector multiplies an actually measured peak area value by the correction coefficient to correct the actual signal value. A device adjustment controller adjusts a voltage applied to an ion detector so that the corrected actual signal value matches with a reference signal value. The voltage applied to the ion detector can be thereby adjusted so that the detector has the same level of gain independent of the ambient temperature.
    Type: Grant
    Filed: January 21, 2015
    Date of Patent: April 16, 2019
    Assignee: SHIMADZU CORPORATION
    Inventor: Manabu Shimomura
  • Patent number: 10254247
    Abstract: Method and systems for managing clear-down are provided. The method can include generating a clear-down trigger associated with an ion mobility spectrometer and operating the ion mobility spectrometer in fast clear-down mode in response to the clear-down trigger. Methods and systems can further provide that where the ion mobility spectrometer operates in fast-switching mode, the ion mobility spectrometer alternating a plurality of times between operation according to a positive ion mode and operation according to a negative ion mode, and further operating according to the positive ion mode for less than about 1 second before switching to the operation according to the negative ion mode, and operating according to the negative ion mode for less than about 1 second before switching to the operation according to the positive ion mode.
    Type: Grant
    Filed: October 27, 2011
    Date of Patent: April 9, 2019
    Assignee: SMITHS DETECTION MONTREAL INC.
    Inventors: Qunzhou Bian, John J. Carroll
  • Patent number: 10241106
    Abstract: There is no small ion detecting apparatus that quickly and easily performs mass spectrometry under atmospheric pressure. Therefore, in order to solve the problem, an electrode arrangement and an electrode holding form for enabling water clusters in outside air to be detected with high sensitivity are provided. By using such solving means, it is possible to detect ions in a place having spatial constraints.
    Type: Grant
    Filed: May 27, 2013
    Date of Patent: March 26, 2019
    Assignee: Hitachi, Ltd.
    Inventor: Minoru Sakairi
  • Patent number: 10241079
    Abstract: The invention proposes a mass spectrometer comprising two ion mobility analyzers in tandem arrangement, of which at least one is a trapped ion mobility spectrometer (TIMS), and an ion gate which is located between the two ion mobility analyzers, and use thereof wherein ions are selectively transferred between the two ion mobility analyzers by adjusting the transmission of the ion gate while ions are separated in time according to ion mobility in the first ion mobility analyzer.
    Type: Grant
    Filed: May 24, 2017
    Date of Patent: March 26, 2019
    Inventors: Thomas Betz, Melvin Andrew Park, Mark Ridgeway
  • Patent number: 10209188
    Abstract: Exemplary methods and systems for incorporating bio-sensors in drones to wirelessly detect biological molecules and hazards without exposing an operator to harmful contaminants or conditions. Bio-sensors can incorporate simultaneous dual-detection methods to ensure accuracy of measurements. Methods of operation include registering blank and safe air profiles for comparison against unknown air profiles to accurately determine the presence of bio-contaminants in unknown air.
    Type: Grant
    Filed: November 1, 2017
    Date of Patent: February 19, 2019
    Assignee: The United States of America, as represented by the Secretary of the Navy
    Inventors: Kin Chiu Ng, Subrata Sanyal
  • Patent number: 10204774
    Abstract: Instruments are disclosed for analyzing ions from about 1000 to 10,000,000 Daltons by controlling a gaseous medium through which the ions travel under the influence of an electric field so that properties of the ions, such as diameter, electrical mobility, and charge, are measured. One embodiment of the disclosed instruments includes an ion source, a nozzle, a jet relaxation region, an ion accumulation region, an electronic gate, a flow chamber and an ion detector.
    Type: Grant
    Filed: May 29, 2017
    Date of Patent: February 12, 2019
    Inventor: W. Henry Benner
  • Patent number: 10203422
    Abstract: A method for calibrating an ionizing radiation detector, with the aim of determining a correction factor in order to establish an amplitude-energy correspondence The invention first relates to a method for calibrating a device for detecting ionizing radiation, the detector comprising a semiconductor or scintillator detection material capable of generating a signal S of amplitude A upon interaction between ionizing radiation and the detection material, the method including the determination of a weighting factor of amplitude A.
    Type: Grant
    Filed: December 18, 2015
    Date of Patent: February 12, 2019
    Assignees: COMMISSARIAT ÀL'ÉNERGIE ATOMIQUE ET AUX ÉNERGIES ALTERNATIVES, SAFRAN IDENTITY & SECURITY
    Inventors: Sylvain Stanchina, Guillaume Montemont
  • Patent number: 10193066
    Abstract: A method may include generating a plasma in a plasma chamber, the plasma comprising an etchant species and extracting a pulsed ion beam from the plasma chamber and directing the pulsed ion beam to a substrate, where the pulsed ion beam comprises an ON portion and an OFF portion. During the OFF portion the substrate may not be biased with respect to the plasma chamber, and the duration of the OFF portion may be less than a transit time of the etchant species from the plasma chamber to the substrate.
    Type: Grant
    Filed: June 30, 2017
    Date of Patent: January 29, 2019
    Assignee: VARIAN SEMICONDUCTOR EQUIPMENT ASSOCIATES, INC.
    Inventors: Glen F. R. Gilchrist, Raees Pervaiz, Kenneth Starks, Shurong Liang, Tyler Rockwell
  • Patent number: 10192715
    Abstract: The invention relates to the measurement of current profiles of free-flying ion or electron clusters which impinge on a detector electrode of a Faraday detector. The detector electrode here consists of a large number of structural elements in a bipolar arrangement, where neighboring structural elements have opposite polarities and structural elements with the same polarity are electrically connected, and a voltage is applied between neighboring structural elements so that before ions or electrons impinge on the detection electrode, they are essentially deflected onto the structural elements with one of the two polarities. If the current profiles on the structural elements of the two polarities are measured separately and subtracted from each other, a current profile which corresponds to the pure ion or electron current profile is obtained without using a screen grid.
    Type: Grant
    Filed: April 21, 2016
    Date of Patent: January 29, 2019
    Inventor: Uwe Renner
  • Patent number: 10163616
    Abstract: A multi-reflecting time-of-flight mass spectrometer comprises a pair of parallel aligned ion mirrors and a set of periodic lenses for confining ion packets along the drift z-direction. To compensate for time-of-flight spherical aberrations T|zz created by the periodic lenses, at least one set of electrodes are disposed within the apparatus, forming an accelerating or reflecting electrostatic fields which are curved in the z-direction in order to form local negative T|zz aberration. The structure may be formed within an accelerator, within flinging fields or intentionally and locally curved fields of ion mirrors, within electrostatic sector interface, or at curved surface of ion to electron converter at the detector.
    Type: Grant
    Filed: October 23, 2014
    Date of Patent: December 25, 2018
    Assignee: LECO Corporation
    Inventors: Anatoly N. Verenchikov, Mikhail I. Yavor
  • Patent number: 10153149
    Abstract: An apparatus 41 and operation method are provided for an electrostatic trap mass spectrometer with measuring frequency of multiple isochronous ionic oscillations. For improving throughput and space charge capacity, the trap is substantially extended in one Z-direction forming a reproduced two-dimensional field. Multiple geometries are provided for trap Z-extension. The throughput of the analysis is improved by multiplexing electrostatic traps. The frequency analysis is accelerated by the shortening of ion packets and either by Wavelet-fit analysis of the image current signal or by using a time-of-flight detector for sampling a small portion of ions per oscillation. Multiple pulsed converters are suggested for optimal ion injection into electrostatic traps.
    Type: Grant
    Filed: September 6, 2017
    Date of Patent: December 11, 2018
    Assignee: LECO Corporation
    Inventor: Anatoly N. Verenchikov
  • Patent number: 10141175
    Abstract: A multi-reflecting, time-of-flight (MR-TOF) mass spectrometer including two quasi-planar electrostatic ion mirrors extended along drill direction (Z) and formed of parallel electrodes, separated by a field free region. The MR-TOF includes a pulsed ion source to release ion packets at a small angle to X-direction which is orthogonal to the drill direction Z. Ion packets are reflected between ion mirrors and drill along the drift direction. The mirrors are arranged to provide time-of-flight focusing ion packets on the receiver. The MR-TOF mirrors provide spatial focusing M the Y-direction orthogonal to both drift direction Z and on injection direction X. In a preferred embodiment, at least one mirror has a feature providing periodic spatial focusing of ion packets in the drift Z-direction.
    Type: Grant
    Filed: August 23, 2016
    Date of Patent: November 27, 2018
    Assignee: LECO Corporation
    Inventors: Anatoli N. Verentchikov, Mikhail I. Yavor
  • Patent number: 10141176
    Abstract: Disclosed herein is a multi-reflection mass spectrometer comprising two ion mirrors spaced apart and opposing each other in an X direction, each mirror elongated along a drift direction Y orthogonal to the direction X, and an ion injector for injecting ions as an ion beam into the space between the ion mirrors at an inclination angle to the X direction. Along a first portion of their length in the drift direction Y the ion mirrors converge with a first degree of convergence, and along a second portion of their length in the drift direction Y the ion mirrors converge with a second degree of convergence or are parallel, the first portion of their length being closer to the ion injector than the second portion and the first degree of convergence being greater than the second degree of convergence.
    Type: Grant
    Filed: November 1, 2017
    Date of Patent: November 27, 2018
    Assignee: Thermo Fisher Scientific (Bremen) GmbH
    Inventors: Hamish Stewart, Dmitry Grinfeld, Alexander A. Makarov
  • Patent number: 10128098
    Abstract: A system for expressing an ion path in a time-of-flight (TOF) mass spectrometer. The present invention uses two successive curved sectors, with the second one reversed, to form S-shaped configuration such that an output ion beam is parallel to an input ion beam, such that the ions makes two identical but opposed turns, and such that the geometry of the entire system folds into a very compact volume. Geometry of a TOF mass spectrometer system in accordance with embodiments of the present invention further includes straight drift regions positioned before and after the S-shaped configuration and, optionally, a short straight region positioned between the two curved sectors with total length equal to about the length of the central arc of both curved sectors.
    Type: Grant
    Filed: September 11, 2017
    Date of Patent: November 13, 2018
    Assignee: NOAA Technology Partnerships Office
    Inventor: Daniel Murphy
  • Patent number: 10119938
    Abstract: Synchronized ion modification systems and techniques are described. An ion modifier can be used to modify a portion of ions that enter a drift chamber via a gate that controls entry of the ions to the drill chamber. A controller that is communicatively coupled to the ion modifier is configured to control the ion modifier to select a portion of the ion to be modified. In embodiments, the controller selects the portion based on a detector's previous response to other ions that are formed from a sample from which the ions were formed. The other ions, for example, correspond to ions that are associated with a peak in previous operation of a spectrometer.
    Type: Grant
    Filed: December 9, 2016
    Date of Patent: November 6, 2018
    Assignee: SMITHS DETECTION—WATFORD LTD.
    Inventors: Stephen J. Taylor, Jonathan R. Atkinson
  • Patent number: 10119937
    Abstract: A method is disclosed for detecting organophosphorus compounds and illicit drugs using an ion detector. A vapor sample containing at least one analyte and at least one dopant is ionized. A proton-bound adduct ion is formed between the analyte and the dopant in a reaction region defined between the ionization source and the ion detector.
    Type: Grant
    Filed: July 15, 2016
    Date of Patent: November 6, 2018
    Assignee: Battelle Memorial Institute
    Inventors: Robert G. Ewing, Blandina R. Valenzuela, David A. Atkinson
  • Patent number: 10096459
    Abstract: Systems and methods for filtering a continuous beam of ions are provided. An acceleration electric field is applied to a continuous beam of ions using an accelerator to produce an accelerated beam of ions. A field is applied to the accelerated beam to separate ions in time and space using a deflector producing a separated beam of ions. The field applied by the deflector is a rotating field or a circulant rastering field. The rotating field can be a rotating magnetic or electric field. Only accept those ions from the separated beam whose m/z values lie within a range centered around a target m/z value using an aperture. The aperture can include a pinhole aperture in a rotating disk or an annular aperture in a first stationary disk, a second deflector, and a pinhole aperture in the center of a second stationary disk.
    Type: Grant
    Filed: September 21, 2015
    Date of Patent: October 9, 2018
    Assignee: DH Technologies Development Pte. Ltd.
    Inventor: Robert Alois Grothe, Jr.
  • Patent number: 10090140
    Abstract: A sample introduction system for a spectrometer comprises a desolvation region that receives or generates sample ions from a solvent matrix and removes at least some of the solvent matrix from the sample ions. A separation chamber downstream of the desolvation region has a separation chamber inlet communicating with the desolvation region, for receiving the desolvated sample ions along with non-ionized solvent and solvent ion vapors. The separation chamber has electrodes for generating an electric field within the separation chamber, defining a first flow path for sample ions between the separation chamber inlet and a separation chamber outlet. Unwanted solvent ions and non-ionized solvent vapors are directed away from the separation chamber outlet. The sample introduction system has a reaction chamber with an inlet communicating with the separation chamber outlet, for receiving the sample ions from the separation chamber and for decomposing the received ions into smaller products.
    Type: Grant
    Filed: January 9, 2017
    Date of Patent: October 2, 2018
    Assignee: Thermo Fisher Scientific (Bremen) GmbH
    Inventors: Alexander A. Makarov, Stevan R. Horning
  • Patent number: 10049867
    Abstract: An apparatus 41 and operation method are provided for an electrostatic trap mass spectrometer with measuring frequency of multiple isochronous ionic oscillations. For improving throughput and space charge capacity, the trap is substantially extended in one Z-direction forming a reproduced two-dimensional field. Multiple geometries are provided for trap Z-extension. The throughput of the analysis is improved by multiplexing electrostatic traps. The frequency analysis is accelerated by the shortening of ion packets and either by Wavelet-fit analysis of the image current signal or by using a time-of-flight detector for sampling a small portion of ions per oscillation. Multiple pulsed converters are suggested for optimal ion injection into electrostatic traps.
    Type: Grant
    Filed: September 5, 2017
    Date of Patent: August 14, 2018
    Assignee: LECO Corporation
    Inventor: Anatoly N. Verenchikov
  • Patent number: 10037873
    Abstract: Multiplexed ion mobility spectrometry (IMS), mass spectrometry (MS) such as time-of-flight mass spectrometry (TOFMS), or hybrid IM-MS is carried out on a sample, and the resulting measurement data are deconvoluted. A pulse sequence controlling ion pulsing is utilized in conjunction with the multiplexing. The pulse sequence may be modified based on the raw measurement data acquired. A demultiplexing matrix based on the modified pulse sequence is utilized to improve deconvolution.
    Type: Grant
    Filed: October 2, 2015
    Date of Patent: July 31, 2018
    Assignee: Agilent Technologies, Inc.
    Inventors: Jun Wang, Ruwan T. Kurulugama
  • Patent number: 10032614
    Abstract: A method and apparatus for analyzing samples using mass spectrometry are disclosed. The apparatus includes a reaction device configured to dissociate sample ions into fragments by reacting the sample ions with a charged species (e.g., electrons) such as through ECD, EID, or EIEIO. The kinetic energy of the charged species is such that the fragments may be detected and produce spectra that allow for the determination of isomeric species in the sample and the location of double bonds of sample molecules. The fragments may include radical fragments and non-radical fragments. The apparatus may also include an oxygen gas source configured to react with the radical fragments to produce oxygen-radical fragments. Spectra resulting from analysis of the fragments may allow for the determination of the oxygen-radical fragments resulting from the dissociation of the sample molecules.
    Type: Grant
    Filed: June 4, 2015
    Date of Patent: July 24, 2018
    Assignee: DH Technologies Development Pte. Ltd.
    Inventors: Takashi Baba, John Lawrence Campbell
  • Patent number: 10026600
    Abstract: A corona discharge ionizer device which emits ions generated by corona discharge to a gas flow to be ionized includes a discharge electrode having a pin configured tip portion. A second grid electrode positioned at a spaced distance from the discharge electrode is provided. The grid electrode is preferably formed from a sheet configured material which has at least one hole formed therein adapted and configured to permit the gas flow to pass therethrough. A power supply is coupled to the discharge electrode and grid electrode configured cause ion emission from the discharge electrode. The power supply is preferably an alternating current power supply configured to produce an alternating electric field region in close proximity to the tip portion of the discharge electrode sufficient to cause avalanche breakdown in the gas flowing in close proximity to the tip portion of the discharge electrode.
    Type: Grant
    Filed: August 9, 2016
    Date of Patent: July 17, 2018
    Assignee: Owlstone Medical Limited
    Inventors: Max Allsworth, Matthew Hart, John Somerville
  • Patent number: 10018592
    Abstract: Methods and apparatuses for ion peak compression and increasing resolution of ions are disclosed. Packets of ions are introduced into a device. A first electric field is applied for dispersing the ion packets temporally or spatially according to their mobilities. A second intermittent traveling wave is applied for regrouping or merging the dispersed ion packets into a lesser number of trapping regions with narrower peaks. The ions packets are compressed into the narrower peak regions by varying a duty cycle of the intermittent traveling wave.
    Type: Grant
    Filed: May 17, 2016
    Date of Patent: July 10, 2018
    Assignee: Battelle Memorial Institute
    Inventors: Yehia M. Ibrahim, Sandilya Garimella, Richard D. Smith
  • Patent number: 10001438
    Abstract: The present invention relates to a method of sensing aerosol characteristic parameters using dual-wavelength light scattered signals and the application thereof, and belongs to the technical field of fire warning. The method procedures include measuring the scattered light power of two different wavelengths, calculating the surface area concentration and the volume concentration of aerosol, and obtaining the Sauter mean diameter of the aerosol the surface area concentration, the volume concentration and the aerosol Sauter mean diameter are compared with corresponding thresholds, and then corresponding fire alarm signals are emitted.
    Type: Grant
    Filed: June 23, 2015
    Date of Patent: June 19, 2018
    Assignee: Huazhong University of Science and Technology
    Inventors: Shu Wang, Tian Deng, Zheng Dou
  • Patent number: 9991106
    Abstract: A method is disclosed comprising passing a signal output from a detector through a programmable attenuator or a programmable amplifier prior to digitizing the signal, and switching an attenuation factor or gain factor of the programmable attenuator or the programmable amplifier one or more times during a data acquisition period.
    Type: Grant
    Filed: August 26, 2016
    Date of Patent: June 5, 2018
    Assignee: MICROMASS UK LIMITED
    Inventors: Martin Raymond Green, Steven Derek Pringle, Keith George Richardson
  • Patent number: 9983099
    Abstract: An ion mobility spectrometer analytical instrument, including an ion mobility spectrometer, a swab interface, and a desorber assembly. The desorber assembly includes a heat transfer device configured to heat a desorber, as well as a supply configured to direct gas through the desorber. The instrument further includes a drift tube, high voltage device arrayed, at least in part, proximate to the drift tube, wherein the high voltage device is configured to change a polarity of a voltage applied to the drift tube and have an absolute voltage of about 500 to 1500 volts. The instrument further includes a reactant supply unit adapted to supply reactant during a sample substance analysis, and a control unit.
    Type: Grant
    Filed: June 10, 2009
    Date of Patent: May 29, 2018
    Assignee: SMITHS DETECTION MONTREAL INC.
    Inventors: Robert T. James, Volodimir Bondarenko, Reno Debono, Julian Burton, John Carroll
  • Patent number: 9978576
    Abstract: Systems and methods are provided for time-of-flight analysis of a continuous beam of ions by a detector array. A sample is ionized using an ion source to produce a continuous beam of ions. An electric field is applied to the continuous beam of ions using an accelerator to produce an accelerated beam of ions. A rotating magnetic and/or electric field is applied to the accelerated beam to separate ions with different mass-to-charge ratios over an area of a two-dimensional detector using a deflector located between the accelerator and the two-dimensional detector. An arrival time and a two-dimensional arrival position of each ion of the accelerated beam are recorded using the two-dimensional detector. Alternatively, an electric field that is periodic with time is applied in order to sweep the accelerated beam over a periodically repeating path on the two-dimensional rectangular detector.
    Type: Grant
    Filed: September 22, 2017
    Date of Patent: May 22, 2018
    Assignee: DH Technologies Development Pte. Ltd.
    Inventor: Robert Alois Grothe, Jr.
  • Patent number: 9947525
    Abstract: A technique for time interval measurement is provided. First and second signal components are received, sampled and digitized. The first signal component is derived from a trigger signal that causes or indicates generation 5 of the second signal component. A time interval between the first and second signal components is determined based on a reference time defined by the sampled and digitized first signal component and based on a reference time defined by the sampled and digitized second signal component.
    Type: Grant
    Filed: May 10, 2016
    Date of Patent: April 17, 2018
    Assignee: Thermo Fisher Scientific (Bremen) GmbH
    Inventors: Matthias Biel, Richard Heming, Anastassios Giannakopulos
  • Patent number: 9934952
    Abstract: The present embodiment relates to a charged-particle detector, etc. provided with a structure for effectively suppressing ion feedbacks under a low-vacuum environment. In order to capture the residual-gas ions, which are generated by collisions between the electrons output from a MCP unit 200 and residual-gas molecules, by a second electrode 400, which is electrically insulated from a first electrode 300, which is mainly for capturing electrons, the potential of the first electrode 300 is set to be higher than an output-side potential of the MCP unit 200, and, on the other hand, the potential of the second electrode 400 is set to be lower than the output-side potential of the MCP unit 200. As a result, the ion feedbacks to the MCP unit 200 are effectively suppressed.
    Type: Grant
    Filed: August 9, 2016
    Date of Patent: April 3, 2018
    Assignee: HAMAMATSU PHOTONICS K.K.
    Inventor: Masahiro Hayashi
  • Patent number: 9891194
    Abstract: The invention provides a method for acquiring fragment ion spectra of substances in complex substance mixtures wherein a trapped ion mobility spectrometer (“TIMS”) is used as the ion mobility separator separation device. The fragment ion spectra may be used for the identification of high numbers of proteins in complex mixtures, or for a safe quantification of some substances, by their fragment ion mass spectra in a mass spectrometer with up-front substance separator. TIMS with parallel accumulation provides the unique possibility to prolong the ion accumulation duration to find more detectable ion species without decreasing the measuring capacity for fragment ion mass spectra. The high measurement capacity for fragment ion mass spectra permits the repeated measurement of low abundance ion species to improve the quality of the fragment ion spectra.
    Type: Grant
    Filed: November 3, 2015
    Date of Patent: February 13, 2018
    Assignees: Bruker Daltonik GmbH
    Inventors: Matthias Mann, Oliver Räther, Melvin Andrew Park, Markus Lubeck
  • Patent number: 9885719
    Abstract: Provided are methods of treating a subject for of ovarian cancer, the method including using lysophosphatidylcholine (16:0) and homocysteic acid, which are low-mass ions present in biological samples, to diagnose whether treatment should be provided. The method enables ovarian cancer to be diagnosed in a cost-effective, rapid and accurate manner.
    Type: Grant
    Filed: August 21, 2014
    Date of Patent: February 6, 2018
    Assignee: Ewha University-Industry Collaboration Foundation
    Inventors: Seung Cheol Kim, Byong Chul Yoo, Kyung-Hee Kim, Yun Hwan Kim
  • Patent number: 9865445
    Abstract: To improve spatial and energy acceptance of multi-reflecting time-of-flight, open traps, and electrostatic trap analyzers, a novel ion mirror is disclosed. Incorporation of immersion lens between ion mirrors allows reaching the fifth order time per energy focusing simultaneously with the third order time per spatial focusing including energy-spatial cross terms. Preferably the analyzer has hollow cylindrical geometry for extended flight path. The time-of-flight analyzer preferably incorporates spatially modulated ion mirror field for isochronous ion focusing in the tangential direction.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: January 9, 2018
    Assignee: LECO Corporation
    Inventors: Anatoly N. Verenchikov, Mikhail I. Yavor
  • Patent number: 9859106
    Abstract: Certain embodiments described herein are directed to reflectron assemblies and methods of producing them. In some configurations, a reflectron comprising a plurality of lenses each comprising a planar body and comprising a plurality of separate and individual conductors spanning a central aperture from a first side to a second side of a first surface of the planar body is described. In some instances, the plurality of conductors are each substantially parallel to each other and are positioned in the same plane.
    Type: Grant
    Filed: May 15, 2016
    Date of Patent: January 2, 2018
    Assignee: PerkinElmer Health Sciences, Inc.
    Inventors: Anthony Chiappetta, Urs Steiner, Keith Ferrara
  • Patent number: 9852895
    Abstract: A mass spectrometer is disclosed comprising an on trap and a fragmentation device. Ions are fragmented in the ion trap to form first generation fragment ions. The ion trap has a relatively high mass cut-off. The first generation fragment ions are then transferred to a fragmentation device which is arranged to have a substantially lower low mass cut-off. The first generation fragment ions are fragmented within the fragmentation device any may optionally be stored in an ion accumulation region prior to being passed to a mass analyser for subsequent mass analysis.
    Type: Grant
    Filed: July 29, 2014
    Date of Patent: December 26, 2017
    Assignee: Micromass UK Limited
    Inventor: Daniel James Kenny