Ion Beam Pulsing Means With Detector Synchronizing Means Patents (Class 250/286)
  • Patent number: 10534093
    Abstract: A circuit arrangement for acquisition of signals from an apparatus for measuring beams of charged particles for external radiotherapy, in particular protons, carbon ions, and other ion species, emitted by particle accelerators, comprising at least one ionization-chamber sensor (10), which includes a plurality of sensor channels (20), said circuit arrangement (200; 500) comprising a plurality of channel branches (B0, . . . , B63; BR0, . . . , BR63) in parallel designed to be connected to said sensor channels (20) for receiving respective measurement signals (i) therefrom, said channel branches (B0, . . . , B63; BR0, . . . , BR63) comprising respective current-to-frequency converters (210) and counters (220) for supplying count values (CT), representing a charge associated to a given channel (20), to a multiplexer (250; 550). According to the invention, said channel branches (BR0, . . . , BR63) supply their own outputs (CT0, . . .
    Type: Grant
    Filed: June 9, 2016
    Date of Patent: January 14, 2020
    Assignees: DE.TEC.TOR S.r.l., Instituto Nazionale di Fisica Nucleare, Universitá degli Studi di Torino
    Inventors: Roberto Sacchi, Giovanni Mazza, Federico Fausti
  • Patent number: 10408792
    Abstract: The invention proposes a mass spectrometer comprising two ion mobility analyzers in tandem arrangement, of which at least one is a trapped ion mobility spectrometer (TIMS), and an ion gate which is located between the two ion mobility analyzers, and use thereof wherein ions are selectively transferred between the two ion mobility analyzers by adjusting the transmission of the ion gate while ions are separated in time according to ion mobility in the first ion mobility analyzer.
    Type: Grant
    Filed: February 5, 2019
    Date of Patent: September 10, 2019
    Inventors: Thomas Betz, Melvin Andrew Park, Mark Ridgeway
  • Patent number: 10276358
    Abstract: An ion mobility spectrometry apparatus and method wherein ions are selected using an AC gate, then separated along a drift axis while providing a drift gas flow in a direction that is substantially neither in the direction of the drift axis nor opposite to the drift axis.
    Type: Grant
    Filed: July 31, 2017
    Date of Patent: April 30, 2019
    Assignee: Excellims Corporation
    Inventors: Ching Wu, Mark A Osgood
  • Patent number: 10209219
    Abstract: Method and systems for monitoring ion mobility spectrometers are provided. The method can include acquiring scan data, and generating a segment data set from the scan data. The method can further include deriving a subset of peak data from the segment data, where the subset of peak data has an associated set of peak metrics, and deriving a value from the subset of peak data associated with a criteria element of the associated set of peak metrics, where the criteria element has an associated range of values. The method can further include providing an indication in the event the value lies outside the associated range of values.
    Type: Grant
    Filed: October 27, 2011
    Date of Patent: February 19, 2019
    Assignee: SMITHS DETECTION MONTREAL INC.
    Inventors: Julian C. Burton, Reno F. DeBono
  • Patent number: 10192729
    Abstract: A method of static gas mass spectrometry is provided. The method includes the steps of: introducing a sample gas comprising two or more isotopes to be analyzed into a static vacuum mass spectrometer at a time, t0; operating an electron impact ionization source of the mass spectrometer with a first electron energy below the ionization potential of the sample gas for a first period of time that is following t0 until a time t1; and operating the electron impact ionization source with a second electron energy at least as high as the ionization potential of the sample gas for a second period of time that is after time t1. The first time period from t0 to t1 is a period corresponding to a period taken for the isotopes of the sample gas to equilibrate in the mass spectrometer. A constant ion source temperature is preferably maintained. Also provided is a static gas mass spectrometer.
    Type: Grant
    Filed: June 2, 2017
    Date of Patent: January 29, 2019
    Assignee: Thermo Fisher Scientific (Bremen) GmbH
    Inventors: Johannes Schwieters, Dougal Hamilton
  • Patent number: 10175197
    Abstract: Apparatus, systems, and methods for reducing or eliminating crosstalk in ion mobility spectrometers are provided. In some aspects, the apparatus, systems, and methods can reduce or eliminate crosstalk without significantly increasing the overall capacitive load of the ion mobility system. In accordance with various aspects of the applicant's teachings, cross talk compensation circuits are disclosed herein that address resulting issues in RF pickup and/or crosstalk in ion mobility spectrometers used with high-sensitivity downstream mass spectrometers such as mass spectrometers having high velocity gas interfaces that can be coupled to the ion mobility spectrometer.
    Type: Grant
    Filed: June 23, 2015
    Date of Patent: January 8, 2019
    Assignee: DH Technologies Development Pte. Ltd.
    Inventors: Manuel Faur, Tiberiu Gera, Bradley B. Schneider, Farshid Tayyeb, John Vandermey
  • Patent number: 9887075
    Abstract: A device for manipulating charged particles using an axial electric field as they travel along a longitudinal axis of the device is disclosed. The method comprises providing an outer electrode for generating an electric field and providing a plurality of inner electrodes that are separated by gaps of different lengths. The electric field generated by the outer electrode penetrates the gaps between the inner electrodes and the gaps are selected such that the desired potential profile is arranged along the longitudinal axis in order to manipulate the charged particles in the desired manner.
    Type: Grant
    Filed: May 28, 2014
    Date of Patent: February 6, 2018
    Assignee: MICROMASS UK LIMITED
    Inventor: John Brian Hoyes
  • Patent number: 9857334
    Abstract: A method of separating ions comprises causing ions to separate according to their ion mobility or differential ion mobility by virtue of their interactions with a buffer gas within an ion mobility or differential ion mobility separation device. The buffer gas comprises one or more organic, organosilicon or silicon-based compounds.
    Type: Grant
    Filed: April 14, 2016
    Date of Patent: January 2, 2018
    Assignee: MICROMASS UK LIMITED
    Inventors: Martin Raymond Green, Keith George Richardson
  • Patent number: 9810664
    Abstract: In a linear drift tube partitioned into a plurality of cascaded drift tube segments each followed by an ion elimination region, a system and method of separating ions includes repeatedly establishing electric drift fields in the drift tube segments and in some of the ion elimination regions while establishing electric repulsive fields in others of the ion elimination regions such that ions having a predefined mobility or range of mobilities are transmitted through the drift tube in one direction, and when the ions reach the end of the drift tube the electric drift fields are reversed and the process is repeated to transmit the ions to the opposite end of the drift tube. Ions may be made to pass back and forth through the drift tube any number of times before being drawn out of the drift tube to an ion detector or into another drift tube.
    Type: Grant
    Filed: March 31, 2016
    Date of Patent: November 7, 2017
    Assignee: Indiana University Research and Technology Corporation
    Inventors: David Edward Clemmer, Michael A. Ewing, Steven M. Zucker, Christopher R. P. Conant
  • Patent number: 9786480
    Abstract: An analytical apparatus for mass spectrometry comprises an electron impact ionizer including an electron emitter and an ionization target zone. The target zone is arranged to be populated with matter to be ionized for analysis. An electron extracting element is aligned with an electron pathway defined between the electron emitter and the ionization target zone. The electron extracting element is configured to accelerate electrons away from the emitter along the electron pathway between the emitter and the extracting element and to decelerate the electrons along the electron pathway between the extracting element and the ionization target zone to enable soft ionization while avoiding the effects of Coulombic repulsion at the electron source.
    Type: Grant
    Filed: August 8, 2016
    Date of Patent: October 10, 2017
    Assignee: MARKES INTERNATIONAL LIMITED
    Inventor: Pierre Schanen
  • Patent number: 9697997
    Abstract: A collision cell for a mass spectrometer arranged to receive ions for fragmentation in a chamber and comprising an activation ion generator configured to irradiate the received ions with activation ions of the same polarity as the received ions. The activation ion generator is preferably a plasma generator, configured to generate a plasma comprising the activation ions.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: July 4, 2017
    Assignee: Thermo Fisher Scientific (Bremen) GmbH
    Inventors: Konstantin Chingin, Roman Zubarev
  • Patent number: 9664657
    Abstract: A detecting method using an IMS apparatus with a preconcentrator outside its inlet aperture. Analyte vapor is adsorbed during a first phase when substantially no gas is admitted to the reaction region. The preconcentrator is then energized to desorb the analyte molecules and create a volume of desorbed molecules outside the IMS housing. Next, a pressure pulser is energized momentarily to drop pressure in the housing and draw in a small sip of the analyte molecules from the desorbed volume through the aperture. This is repeated until the concentration of analyte molecules in the desorbed volume is too low for accurate analysis, following which the apparatus enters another adsorption phase.
    Type: Grant
    Filed: May 22, 2014
    Date of Patent: May 30, 2017
    Assignee: Smiths Detection—Watford Limited
    Inventor: Stephen John Taylor
  • Patent number: 9564303
    Abstract: The invention relates to a low-cost spring steel plate as the sample support on a dimensionally stable and precisely shaped substructure, machined from an aluminum alloy, for example, and using a pattern of embedded magnets so that said plate is removable and that a body is created overall which is suitable for use in robots, for example by giving it the dimensions of a conventional microtitration plate. The planarity of the surface onto which the (organic) samples are applied is provided within the near region by the spring steel plate itself and in the far region over the whole spring steel plate by the substructure. The spring steel plate may be designed for single use in order to satisfy IVD diagnostic regulations also, for example. It can be equipped with identification codes, sample site markings and pre-coatings for different types of analytical tasks, such as MALDI-TOF mass spectrometric analysis.
    Type: Grant
    Filed: September 22, 2015
    Date of Patent: February 7, 2017
    Inventor: Jens Hoehndorf
  • Patent number: 9535051
    Abstract: An investment casting shell substrate sensor method and apparatus comprising a hollow probe 10 having an aperture 30, the aperture 30 covered by a water proof breathable membrane (WPBM) 20 that is constructed and arranged to repel liquid from entering the aperture 30, while remaining permeable so as to allow vapor and air to pass through the aperture 30, thereby creating a liquid free internal void 50 within the hollow probe 10 that receives a sensor 40 for measuring the conditions (i.e. temperature and humidity) within the internal void 50, which are accurately indicative of the conditions at the shell substrate at the aperture 30 location. The disclosed sensor assembly provides target specific information at selected substrates within the shell real time, during the shell building process.
    Type: Grant
    Filed: October 4, 2013
    Date of Patent: January 3, 2017
    Inventor: Julie Markee
  • Patent number: 9528372
    Abstract: An automatic method for providing geological trends and real time mapping of a geological basin using a mass spectrometer. The method provides information from a mass spectrometer on fluid samples from a wellbore into a geochemical surface well log with graphical tracks in real time. The dataset includes geochemical, engineering, and geological. The viewable geochemical well log provides information on well fluids and rock, and displays data in graphical tracks on client devices. The mass spectrometer receives samples from a gas trap connected to the wellbore, performs analysis on the samples, and communicates in real time to a geochemical surface well log with a plurality of graphical tracks which is then further communicated to a client device via a network.
    Type: Grant
    Filed: October 25, 2013
    Date of Patent: December 27, 2016
    Assignee: SELMAN AND ASSOCIATES, LTD.
    Inventors: Thomas H. Selman, Matthew J. Jennings
  • Patent number: 9524858
    Abstract: An analytical apparatus (1) for mass spectrometry comprises an electron impact ioniser including an electron emitter (22) and an ionisation target zone (18). The target zone (18) is arranged to be populated with matter to be ionised for analysis. An electron extracting element (36) is aligned with an electron pathway (34) defined between the electron emitter (22) and the ionisation target zone (18). The electron extracting element (36) is configured to accelerate electrons away from the emitter (22) along the electron pathway (34) between the emitter (22) and the extracting element (36) and to decelerate the electrons along the electron pathway (34) between the extracting element (36) and the ionisation target zone (18) to enable soft ionisation while avoiding the effects of coulombic repulsion at the electron source (22).
    Type: Grant
    Filed: February 19, 2014
    Date of Patent: December 20, 2016
    Assignee: Markes International Limited
    Inventor: Pierre Schanen
  • Patent number: 9494344
    Abstract: A method for converting a cryostat configuration (1) having a first container (2) with a liquid helium bath (3) and a second container (6) which is filled with liquid nitrogen (7) is characterized in that a cooling medium (12) which is in a gaseous state at a temperature of 60K and a pressure of 1 bar, is introduced into the second container and is cooled by a refrigerator (16) by means of a cooling circuit (11), the coolant lines of which are guided into the second container, to an operating temperature of ?60K. With this retrofit for existing cryostat configurations that utilize both liquid helium and also liquid nitrogen for cooling a superconducting coil, use of liquid nitrogen can be completely avoided and the evaporation rate of the liquid helium can also be considerably reduced without having to re-liquefy the cryogens used.
    Type: Grant
    Filed: July 1, 2014
    Date of Patent: November 15, 2016
    Assignee: Bruker BioSpin AG
    Inventors: Andreas Kraus, Robert Schauwecker, Joerg Hinderer
  • Patent number: 9490114
    Abstract: In an ion reflector (4) configured from a plurality of electrodes, electrodes 42 disposed in a second stage region (S2) for reflecting ions after deceleration are formed thinner than electrodes (41) disposed in a first stage region (S1) for decelerating the ions. The thin electrodes suppress unevenness of potential, in particular, in a path away from the center axis of the reflector, which results in improvement of isochronism of an ion packet passing on the path. The thick electrodes (41, 43) disposed in the first stage region (S1) prevents stretching of the grid electrodes (G1, G2) from being affected, and unevenness of potential in the first stage region (S1) hardly affects isochronism of the ions. By appropriately adjusting thicknesses and a pitch of the electrodes (41, 42, 43, 44) adjacent to one another so as to align intervals between the electrodes (41, 42, 43, 44), it is possible to use spacers having the same size in common.
    Type: Grant
    Filed: September 18, 2013
    Date of Patent: November 8, 2016
    Assignee: SHIMADZU CORPORATION
    Inventor: Osamu Furuhashi
  • Patent number: 9417211
    Abstract: A method and apparatus are disclosed for improving ion mobility spectrometry by using a fast and spatially wide ion gate based on local RF field barrier opposed to a switching DC field. The improvement accelerates the ion mobility analysis and improves charge throughput and dynamic range of the IMS. The invention is particularly suited for rapid dual gas chromatography. In one important embodiment, the accelerated IMS is coupled to a multi-reflecting time-of-flight mass spectrometer with a fast encoded orthogonal acceleration. There are described methods of comprehensive and orthogonal separation in multiple analytical dimensions.
    Type: Grant
    Filed: December 30, 2014
    Date of Patent: August 16, 2016
    Assignee: LECO Corporation
    Inventor: Anatoly N. Verenchikov
  • Patent number: 9401514
    Abstract: The present invention provides a fuel cell separator and a method for surface treatment of the same, in which ionized nanoparticles are attached to the surface of a separator to form fine projections such that the surface of the separator exhibits superhydrophobicity. For this purpose, the present invention provides a method for surface treatment of a fuel cell separator which provides nanoparticles for forming fine projections on the surface of the separator to a discharge electrode and ionizes the nanoparticles by an arc discharge generated in the discharge electrode. The ionized nanoparticles are then attached to the surface of the separator by an electric field generated by applying a high voltage between the separator and the discharge electrode, thereby forming fine projections for imparting superhydrophobicity.
    Type: Grant
    Filed: May 12, 2011
    Date of Patent: July 26, 2016
    Assignees: Hyundai Motor Company, Kia Motors Corporation
    Inventors: Haeng Jin Ko, Sae Hoon Kim, Yoo Chang Yang, Yun Seok Kim
  • Patent number: 9366649
    Abstract: An apparatus, system and method for detecting, identifying, classifying and/or quantifying chemical species in a gas flow using a micro-fabricated ion filter coupled to a system adapted to apply drive signals to the ion filter. Coupled to the ion filter is a system adapted to measure the output of the ion filter, which in turn is coupled to a system adapted to extract numerical parameters from the measured output of the ion filter to facilitate chemical detection, identification, classification and/or quantification of the gas flow.
    Type: Grant
    Filed: March 28, 2013
    Date of Patent: June 14, 2016
    Assignee: Owlstone Nanotech Inc
    Inventors: Ashley Wilks, Matthew Hart, Stephen Hartwell, Alison Hart, Lara Jamieson, Max Allsworth, John Somerville
  • Patent number: 9347917
    Abstract: The applicants' teachings provide in some aspects methods and apparatus for mass spectrometric analysis that identify the location of carbon-carbon double bonds, if any, in an analyte by (1) obtaining the m/z ratio of the intact analyte ions, (2) subjecting these ions to collision-induced dissociation and (3) determining relationships between masses and/or mass-to-charge ratios of the intact analyte ions and the fragments produced by such collision-induced dissociation. The methods and apparatus selectively subject analyte ions to ozone-induced dissociation based on those relationships and determine location(s) of carbon-carbon double bonds, if any, from reaction products of ozone-induced dissociation.
    Type: Grant
    Filed: March 28, 2013
    Date of Patent: May 24, 2016
    Assignee: DH Technologies Development Pte. Ltd.
    Inventors: John Lawrence Campbell, Eva Duchoslav, Stephen Blanksby, Todd Mitchell
  • Patent number: 9310335
    Abstract: Devices and techniques for ion analysis, including ion mobility separation and mass spectrometry, are provided using a dual polarity spark ion source and having the flexibility required to optimize the detection performance for a broad range of illicit substances with different physical and chemical properties. In various embodiments, the volatility and electro-chemical aspects may be addressed by the system described herein by performing real-time detection of compounds detectable in both positive and negative polarities and/or prioritizing spectra acquisition in a given polarity due to the high volatility and therefore short residence of certain target compounds.
    Type: Grant
    Filed: June 27, 2014
    Date of Patent: April 12, 2016
    Assignee: Implant Sciences Corporation
    Inventors: Said Boumsellek, Dmitriy V. Ivashin
  • Patent number: 9293313
    Abstract: Provided is a spatial focusing ion mobility tube, including an ionzation source, an ion gate, a grid mesh and a faraday disc. A focusing grid mesh parallel to the ion gate is provided at one side of the ion gate away from the ionization source, and the ion gate and the focusing grid mesh combine into a spatial focusing ion gate assembly which controls the flight of the ions. The mobility tube employs a traditional design and changes the ion gate portion to one or more spatial focusing ion gate assemblies. The spatial focusing assembly can realize the injection function of the ion gate and produce the spatial compression focusing of ions.
    Type: Grant
    Filed: November 18, 2011
    Date of Patent: March 22, 2016
    Assignee: DALIAN INSTITUTE OF CHEMICAL PHYSICS, CHINESE ACADEMY OF SCIENCES
    Inventors: Haiyang Li, Yongzhai Du, Weiguo Wang
  • Patent number: 9267920
    Abstract: For ion mobility spectrometry applications, a desired shape of a sensor structure may be created by forming a desired shape from a ceramic material, such as aluminum nitride. In various embodiments, the sensor structure may be formed using discrete individual ceramic sheets and/or from a preformed ceramic tube. Via holes are formed into the sensor structure to provide for efficient circuitry configurations of the IMS drift tube and/or providing electrical connections between the interior and exterior of the drift tube.
    Type: Grant
    Filed: February 26, 2014
    Date of Patent: February 23, 2016
    Assignee: Implant Sciences Corporation
    Inventors: Andrew G. Anderson, Troy A. Velazquez, Dmitriy V. Ivashin, Said Boumsellek
  • Patent number: 9230773
    Abstract: A plasma chamber having improved controllability of the ion density of the extracted ribbon ion beam is disclosed. A plurality of pairs of RF biased electrodes is disposed on opposite sides of the extraction aperture in a plasma chamber. In some embodiments, one of each pair of RF biased electrodes is biased at the extraction voltage, while the other of each pair is coupled to a RF bias power supply, which provides a RF voltage having a DC component and an AC component. In another embodiment, both of the electrodes in each pair are coupled to a RF biased power supply. A blocker may be disposed in the plasma chamber near the extraction aperture. In some embodiments, RF biased electrodes are disposed on the blocker.
    Type: Grant
    Filed: October 16, 2014
    Date of Patent: January 5, 2016
    Assignee: Varian Semiconductor Equipment Associates, Inc.
    Inventors: Alexandre Likhanskii, Svetlana B. Radovanov, Bon-Woong Koo
  • Patent number: 9188565
    Abstract: Improved methods and devices for analysis of gas phase ions via ion mobility type analyzers, particularly high field asymmetric waveform ion mobility analyzers (FAIMS), by linking gas composition and/or flow rate with the scanning of compensation voltage or asymmetric waveform amplitude are provided. Linking these parameters results in improvements in resolution, sensitivity, and selectivity. The methods and devices according to the presently disclosed subject matter provide for the improvement in resolution for specific ions without affecting the entire FAIMS spectrum.
    Type: Grant
    Filed: May 31, 2012
    Date of Patent: November 17, 2015
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Gary Glish, Mark Ridgeway, Alice Pilo
  • Patent number: 9171711
    Abstract: A mass spectrometer system and method of operating same are provided. The system comprises an ion conduit for receiving ions; a boundary member defining a curtain gas chamber containing the ion conduit; a curtain gas supply for providing a curtain gas to an inlet of the ion conduit to provide a gas flow into the conduit, and a curtain gas outflow out of a curtain gas chamber inlet; a mass spectrometer at least partially sealed to, and in fluid communication with, the conduit for receiving the ions from the conduit; a vacuum chamber surrounding the mass spectrometer operable to draw the gas flow including the ions through the conduit and into the vacuum chamber; and, a gas outlet for drawing a gas outflow from the gas flow located between the conduit and the mass spectrometer to increase the gas flow rate through the conduit.
    Type: Grant
    Filed: August 15, 2013
    Date of Patent: October 27, 2015
    Assignee: DH Technologies Development Pte. Ltd.
    Inventors: Bradley B. Schneider, Thomas R. Covey
  • Patent number: 9110011
    Abstract: Disclosed are a remote measurement system and method for pesticide fog distribution and drifting tendency in aerial pesticide application, which relate to the technical field of hazardous substance monitoring. The system comprises: a collection module, used for collecting infrared radiation in a detected area, and enabling the infrared radiation to be incident on an optical module; the optical module, used for obtaining, according to the incident infrared radiation, an infrared imaging spectrum in the detected area where a pesticide fog cloud cluster is distributed, and sending the infrared imaging spectrum to a processing module; the processing module, used for analyzing the infrared imaging spectrum, identifying the pesticide fog cloud, obtaining a concentration image of the pesticide fog cloud through inversion, and predicting a drifting tendency of the pesticide fog according to the concentration image.
    Type: Grant
    Filed: October 13, 2011
    Date of Patent: August 18, 2015
    Assignee: BEIJING RESEARCH CENTER FOR INFORMATION TECHNOLOGY IN AGRICULTURE
    Inventors: Chunjiang Zhao, Wengang Zheng, Daming Dong, Xiande Zhao, Changjun Shen, Wenbiao Wu, Hua Yan, Shirui Zhang, Feng Bao
  • Patent number: 9093254
    Abstract: A mass spectrometer (MS) that is adapted to allow rapid gas-phase hydrogen/deuterium exchange (HDX) labeling of ions in one or more traveling wave ion guides (TWIGs) with or without ion mobility separation. The addition of isotopic labeling by gas-phase HDX offers a sensitive alternative dimension for conformational detection, which enables high resolution detection of gaseous conformations based on shape and surface reactivity. Gas-phase, isotopic HDX labeling or “curtain” labeling, can be performed by infusing a reactive, isotopic labeling gas, e.g., ND3, into one or more of the traveling-ion wave guides (TWIG) in the MS. Analyte ions retained in the potential wells of a traveling wave generated by one or more of the TWIGs can be isotopic labeled at adjustable gas pressures. Labeling times can also be controlled by adjusting the speed of the traveling wave and can be performed within milliseconds of ionizations, probing protein conformations present in solution.
    Type: Grant
    Filed: April 14, 2010
    Date of Patent: July 28, 2015
    Assignees: Northeastern University, Micromass UK Limited
    Inventors: Kasper D. Rand, John R. Engen, Robert H. Bateman
  • Patent number: 9082596
    Abstract: A method of mass spectrometry is disclosed comprising passing ions through an ion mobility spectrometer and acquiring first ion mobility drift time data. A calibration function is applied to the first ion mobility drift time data to determine a physico-chemical property (e.g. CCS) of the ions. Second ion mobility drift time data is then acquired and the calibration function is applied to the second ion mobility drift time data to determine the physico-chemical property of one or more known or reference ions. The calibration function is then adjusted.
    Type: Grant
    Filed: June 1, 2012
    Date of Patent: July 14, 2015
    Assignee: Micromass UK Limited
    Inventors: Jeffery Mark Brown, Kevin Giles
  • Patent number: 9063086
    Abstract: A method and apparatus for compressing ions inside an ion mobility device is disclosed. Ions are introduced into the mobility device. The ions are subjected to a non-constant electric field to form a potential gradient along a portion of the device so that ions with similar mobilities bunch together into sharper peaks while maintaining separation between other ions. The potential gradient progressively increases or decreases along the length of the device.
    Type: Grant
    Filed: February 12, 2014
    Date of Patent: June 23, 2015
    Assignee: BATTELLE MEMORIAL INSTITUTE
    Inventors: Sandilya V. B. Garimella, Yehia M. Ibrahim, Gordon A. Anderson, Richard D. Smith
  • Patent number: 9035242
    Abstract: An improved nanoparticle sizing apparatus comprised of a unipolar charger operatively coupled to a radial differential mobility analyzer in combination with a condensation particle counter and powered by a power source such as a battery or solar cell, thereby providing a portable sizing device.
    Type: Grant
    Filed: January 18, 2013
    Date of Patent: May 19, 2015
    Assignee: TSI INCORPORATED
    Inventors: Robert Caldow, Jason Johnson
  • Patent number: 9035239
    Abstract: The invention generally relates to systems and methods for mass spectrometry analysis of microorganisms in samples.
    Type: Grant
    Filed: January 12, 2015
    Date of Patent: May 19, 2015
    Assignee: Purdue Research Foundation
    Inventors: Robert Graham Cooks, Ahmed Mohamed Hamid, Alan Keith Jarmusch, Zheng Ouyang
  • Patent number: 9018596
    Abstract: A device for imparting an orbital angular momentum to a charged particle wave propagating along a beam axis in a charged particle beam generating apparatus is described. The device comprises a support element having a target region adapted for transmitting a charged particle wave propagating along a beam axis and an induction means for inducing a magnetic flux along an elongated profile having a free end portion located in the target region and the induction means is adapted for providing a magnetic flux in the elongated profile in order to induce an angular gradient, relative to the beam axis, of the phase of the charged particle wave when transmitted through the target region. A corresponding method is also disclosed, as well as the use thereof in electron microscopy.
    Type: Grant
    Filed: December 19, 2012
    Date of Patent: April 28, 2015
    Assignee: Universiteit Antwerpen
    Inventors: Johan Verbeeck, Gustaaf Van Tendeloo
  • Publication number: 20150108345
    Abstract: Shutter gate grid is a structure wherein first and second disc-shaped members made of metal with an insulation sheet member sandwiched therebetween are integrally joined by means of insulative screws. Gate grids with conductive wires secured to the central openings thereof are fused onto the disc-shaped members; screw insertion holes formed in the second disc-shaped member are fan-shaped and have play in the direction of rotation, making it possible to adjust the parallelism of the conductive wires of the two members by finely adjusting the rotational position when tightening the screws. Moreover, diffusion gas can be made to flow through ventilation holes provided at common locations on each member, thus making it possible to provide uniformity of diffusion gas flow in the drift region.
    Type: Application
    Filed: October 6, 2014
    Publication date: April 23, 2015
    Applicant: SHIMADZU CORPORATION
    Inventor: Ryo FUJITA
  • Patent number: 9000363
    Abstract: The present invention provides a radio frequency (RF) power supply in a mass spectrometer. The power supply provides an RF signal to electrodes of a storage device to create a trapping field. The RF field is usually collapsed prior to ion ejection. In an illustrative embodiment the RF power supply includes a RF signal supply; a coil arranged to receive the signal provided by the RF signal supply and to provide an output RF signal for supply to electrodes of an ion storage device; and a shunt including a switch operative to switch between a first open position and a second closed position in which the shunt shorts the coil output.
    Type: Grant
    Filed: November 7, 2013
    Date of Patent: April 7, 2015
    Assignee: Thermo Finnigan LLC
    Inventors: Alexander A. Makarov, Eduard V. Denisov, Alexander Kholomeev
  • Patent number: 8975577
    Abstract: LC/MS data generated by an LC/MS system is analyzed to determine groupings of ions associated with originating molecules. Ions are grouped initially according to retention time, for example, using retention time or chromatographic peaks in mass chromatograms. After initial groupings are determined based on retention time, ion peak shapes are compared to determine whether ions should be excluded. Ions having peak shapes not matching other ions, or alternatively a reference peak shape, are excluded from the group.
    Type: Grant
    Filed: August 8, 2014
    Date of Patent: March 10, 2015
    Assignee: Waters Technologies Corporation
    Inventors: Scott J. Geromanos, Jeffrey Cruz Silva, Guo-Zhong Li, Marc Victor Gorenstein
  • Patent number: 8975579
    Abstract: A mass spectrometer having a mass filter which applies a transient voltage profile to accelerate ion packets. The voltage profile is chosen to have a functional form which imparts each ion species with a kinetic energy which is larger the larger the mass-to-charge ratio and a velocity which is smaller the larger the mass-to-charge ratio. The ions are detected in an ion detector which discriminates between different ion species based on their kinetic energy and taking account of the functional form of the voltage profile. Suitable voltage profiles include periodic functions such as sinusoids, triangles and sawtooths, which allow the amplification of drive pulses in the mass filter to be carried out with narrow band amplification stages, which are simple and inexpensive to construct.
    Type: Grant
    Filed: March 2, 2011
    Date of Patent: March 10, 2015
    Assignee: Ilika Technologies Limited
    Inventors: David Bream, Christopher Newman, Brian Christopher Webb
  • Patent number: 8969797
    Abstract: The length of a delay time d from a suspension period starting point t1 until the application of a pulse voltage is begun is changed according to the length of the suspension period during which no data is collected at the time of m/z switching. It is thus ensured that the amount of product ions can be reliably restored at a suspension period termination point t2. In addition, the peak value of the pulse voltage is also changed according to the ionic strength immediately before entering the suspension period. The ion removal rate is thus increased when the amount of remaining ions is high, and the amount of remaining ions is reliably brought to zero within the same pulse width. As a result, crosstalk can be completely removed.
    Type: Grant
    Filed: October 28, 2012
    Date of Patent: March 3, 2015
    Assignee: Shimadzu Corporation
    Inventor: Shinjiro Fujita
  • Patent number: 8969796
    Abstract: The present invention provides a timing device, especially a timing device for use in mass spectrometers, for example TOF mass spectrometers, for processing trigger signal data containing a trigger signal indicating the occurrence of a trigger event, the timing device having: a trigger signal deserializer configured to receive trigger signal data containing a trigger signal indicating the occurrence of a trigger event as serial data and to output the trigger signal data as parallel data, and wherein suitably the timing device has a processing means configured to process trigger signal data outputted by the trigger signal deserializer as parallel data.
    Type: Grant
    Filed: March 12, 2014
    Date of Patent: March 3, 2015
    Assignee: Kratos Analytical Limited
    Inventor: Ian Sherwood
  • Patent number: 8963076
    Abstract: In a mass cytometer or mass spectrometer, a sample of elemental tagged particles is transferred from a dispersion to a gas flow through a carrier aerosol spray for atomization and ionization by inductively coupled plasma (ICP) source. The configuration of the sample transfer apparatus allow for total consumption of the sample by passing the sample spray through a deceleration stage to decelerate the spray of particles from its high velocity expansion. Following the deceleration stage, the decelerated sample of particles can be accelerated and focused through an acceleration stage for transferring into the ICP. This effectively improves the particle transfer between the sample spray and the ICP.
    Type: Grant
    Filed: October 26, 2012
    Date of Patent: February 24, 2015
    Assignee: Fluidigm Canada Inc.
    Inventor: Raymond Jong
  • Patent number: 8963079
    Abstract: The invention generally relates to systems and methods for transferring ions for analysis. In certain embodiments, the invention provides a system for analyzing a sample including an ionizing source for converting molecules of a sample into gas phase ions in a region at about atmospheric pressure, an ion analysis device, and an ion transfer member operably coupled to a gas flow generating device, in which the gas flow generating device produces a laminar gas flow that transfers the gas phase ions through the ion transfer member to an inlet of the ion analysis device.
    Type: Grant
    Filed: August 8, 2014
    Date of Patent: February 24, 2015
    Assignee: Purdue Research Foundation
    Inventors: Zheng Ouyang, Robert Graham Cooks, Sandilya Venkata Garimella, Jason David Harper, Nicholas Alan Charipar
  • Patent number: 8941056
    Abstract: A mass spectrometer is disclosed wherein an ion signal is split into a first and second signal. The first and second signals are multiplied by different gains and are digitized. Arrival time and intensity pairs are calculated for both digitized signals and the resulting time and intensity pairs are combined to form a high dynamic range spectrum. The spectrum is then combined with other corresponding spectra to form a summed spectrum.
    Type: Grant
    Filed: May 6, 2014
    Date of Patent: January 27, 2015
    Assignee: Micromass UK Limited
    Inventors: Martin Raymond Green, Steven Derek Pringle, Jason Lee Wildgoose
  • Patent number: 8933399
    Abstract: When a specimen from a specimen ionizing unit is not sufficiently ionized, is caused to remain in sites other than a pore in an introducing section and be deposited as a product such as an oxide or carbide, which causes a deterioration in the performance of the mass spectrometry device. The mass spectrometry device has a specimen ionizing section for ionizing a specimen, a specimen-introduction regulating chamber into which ions of the ionized specimen are introduced, a differential evacuation chamber located downstream of the specimen-introduction regulating chamber, and an analyzing section located at the downstream side of the differential evacuation chamber, in which a discharge generating means is formed for generating an electric discharge inside the specimen-introduction regulating chamber and/or the differential evacuation chamber.
    Type: Grant
    Filed: April 9, 2012
    Date of Patent: January 13, 2015
    Assignee: Hitachi High-Technologies Corporation
    Inventor: Makoto Sampei
  • Patent number: 8921775
    Abstract: A Time of Flight mass analyser is disclosed comprising one or more devices arranged and adapted to correct for tilt in an isochronous plane of ions and to adjust the isochronous plane of the ions so as to be parallel with the plane of detection in an ion detector.
    Type: Grant
    Filed: March 13, 2012
    Date of Patent: December 30, 2014
    Assignee: Micromass UK Limited
    Inventors: David J. Langridge, Jason Lee Wildgoose, John Brian Hoyes
  • Patent number: 8884220
    Abstract: An ion detector for a Time of Flight mass spectrometer is disclosed comprising a single Microchannel Plate 1 which is arranged to receive ions 2 and output electrons 3. The electrons 3 are directed onto an array of photodiodes 4 which directly detects the electrons 3. The output from each photodiode 4 is connected to a separate Time to Digital Converter provided on an ASIC 5.
    Type: Grant
    Filed: September 28, 2012
    Date of Patent: November 11, 2014
    Assignee: Micromass UK Limited
    Inventors: John Brian Hoyes, Anthony James Gilbert, Motohiro Suyama
  • Patent number: 8866074
    Abstract: An ion trap is provided between a collision cell and a time-of-flight mass separator. During a time period in which precursor ions derived from the same compound are selected with a quadrupole mass filter, a collision energy is changed from one to another. Various product ions that are produced by dissociation respectively under collision energies of the plurality of stages and precursor ions that are not dissociated are temporarily trapped in the ion trap, and are ejected in a packet form in the state where these ions are mixed, and are introduced into the time-of-flight mass separator 6 to be subjected to a mass spectrometry. Thereby, in a data processing unit, one MS/MS spectrum in which product ions produced in various dissociation modes under various CID conditions appear is created.
    Type: Grant
    Filed: February 24, 2014
    Date of Patent: October 21, 2014
    Assignee: Shimadzu Corporation
    Inventor: Daisuke Okumura
  • Patent number: 8853623
    Abstract: A method, apparatus and algorithms are disclosed for operating an open electrostatic trap (E-trap) or a multi-pass TOF mass spectrometer with an extended flight path. A string of start pulses with non equal time intervals is employed for triggering ion packet injection into the analyzer, a long spectrum is acquired to accept ions from the entire string and a true spectrum is reconstructed by eliminating or accounting overlapping signals at the data analysis stage while using logical analysis of peak groups. The method is particularly useful for tandem mass spectrometry wherein spectra are sparse. The method improves the duty cycle, the dynamic range and the space charge throughput of the analyzer and of the detector, so as the response time of the E-trap analyzer. It allows flight extension without degrading E-trap sensitivity.
    Type: Grant
    Filed: April 14, 2011
    Date of Patent: October 7, 2014
    Assignee: LECO Corporation
    Inventor: Anatoly N. Verenchikov
  • Patent number: 8835837
    Abstract: LC/MS data generated by an LC/MS system is analyzed to determine groupings of ions associated with originating molecules. Ions are grouped initially according to retention time, for example, using retention time or chromatographic peaks in mass chromatograms. After initial groupings are determined based on retention time, ion peak shapes are compared to determine whether ions should be excluded. Ions having peak shapes not matching other ions, or alternatively a reference peak shape, are excluded from the group.
    Type: Grant
    Filed: April 10, 2013
    Date of Patent: September 16, 2014
    Assignee: Waters Technologies Corporation
    Inventors: Scott J. Geromanos, Jeffrey Cruz Silva, Guo-Zhong Li, Marc Victor Gorenstein