With Sample Supply Means Patents (Class 250/288)
  • Patent number: 11412953
    Abstract: Described are methods and uses employing metabolomic data to diagnose an asthma disease state or a Chronic Obstructive Pulmonary Disease (COPD) state. Further described are methods of uses of employing metabolomic data to distinguish between asthma and COPD. In particular, urinary metabolomic profiles are employed to enable differential diagnosis of asthma and COPD.
    Type: Grant
    Filed: August 31, 2020
    Date of Patent: August 16, 2022
    Assignee: University of Saskatchewan
    Inventors: Darryl Adamko, Anas El-Aneed
  • Patent number: 11417507
    Abstract: The present invention relates to improving the ability of a hyphenated instrument to analyze a sample benefiting from having the first instrument's analysis of the same sample. A fast switching mechanism can be used as the interface between an ion mobility spectrometer (IMS) and a mass spectrometer (MS) such that the obtained IMS spectrum is converted into a timing diagram that controls the vacuum inlet's size dynamically during analysis of a neutral and/or charged chemical and/or biological species such that a smaller pumping system can be used. In various operational modes of the IMS-MS device, mobility-separated ions are allowed to pass through an ion gate and the vacuum inlet for mass analysis.
    Type: Grant
    Filed: November 30, 2020
    Date of Patent: August 16, 2022
    Inventors: Mark A Osgood, Ching Wu
  • Patent number: 11406768
    Abstract: The invention is concerned with a simple and reliable manner of monitoring a handling or use of injection devices by means of a reusable electronic module. According to the invention, a displacement of a component of the injection device between an initial position and an intermediate position, and a subsequent displacement of the same component between the intermediate position and a final position essentially identical with the initial position is observed by one and the same sensor comprised in an electronic module separate from the injection device. A status or state of the injection device is then inferred in the electronic module from these two observations by way of digitally processing sensor output information. The invention thus enables secure, easy and cost-effective operation of components, devices and systems for the generation, collection and distribution of data associated with the handling or use of the injection devices.
    Type: Grant
    Filed: March 25, 2019
    Date of Patent: August 9, 2022
    Assignee: Ypsomed AG
    Inventors: Michael Gentz, Ursina Streit, Marcel Derungs, Leos Urbanek, Daniel Burgener, Jonas Rihs
  • Patent number: 11410843
    Abstract: Provided are a mass spectrometry system and a measuring method thereof. The mass spectrometry system comprises an ion source subsystem, an ion accelerator subsystem, a high-energy analyzer subsystem and a particle identification and detector subsystem which are sequentially connected. The ion source subsystem comprises a sampler component and a super-strong ionization ion source component connected with the sampler component; the high-energy analyzer subsystem comprises an analyzer component connected with the ion accelerator subsystem and a beam measuring component connected with the analyzer component; and the detector subsystem comprises a film connected with the beam measuring component and a detector connected with the film. A super-strong ionization technology is employed to eliminate interference of molecular ions; and an atomic number Z can be detected by using a particle identification technology, so as to obtain isobaric ions and information of ions with different mass numbers but the same M/q.
    Type: Grant
    Filed: January 23, 2022
    Date of Patent: August 9, 2022
    Inventor: Shan Jiang
  • Patent number: 11402385
    Abstract: A method of mass spectrometry determines if a mutated variant of a target protein is present in a sample. The method includes subjecting the sample to fragmentation so as to cause the target protein to fragment to form second generation fragment ions, and then mass analysing these fragment ions to obtain spectral data. The method determines if a mutated variant is present in the sample by determining that an ion in the spectral data has a mass to charge ratio that differs from the mass to charge ratio of an ion that would be observed if the target protein was a normal unmutated version of the target protein, and by an amount that corresponds to a mass difference that would be caused by the target protein being a mutated variant of the target protein.
    Type: Grant
    Filed: October 1, 2015
    Date of Patent: August 2, 2022
    Assignee: MICROMASS UK LIMITED
    Inventors: Jeffery Mark Brown, Michael Raymond Morris, Jonathan Williams, Brian Green
  • Patent number: 11397168
    Abstract: Mass spectrometry for a specimen is repeatedly performed while stepwise changing a parameter (for example, a current value) of an emitter current. Based on a plurality of chromatograms generated by this process, an evaluation value table including a plurality of evaluation values is generated. An individual evaluation value shows a degree of tailing for individual peak included in each chromatogram. A parameter function is generated based on the evaluation value table. The parameter of the emitter current is controlled according to the parameter function.
    Type: Grant
    Filed: November 20, 2019
    Date of Patent: July 26, 2022
    Assignee: JEOL Ltd.
    Inventor: Masaaki Ubukata
  • Patent number: 11393669
    Abstract: A mass spectrometer includes: an ion source; a collision cell into which a predetermined gas is introduced, for allowing an ion generated in the ion source to be in contact with the predetermined gas; and a quadruple mass filter for performing mass spectrometry on the ion ejected from the collision cell. The mass spectrometer further includes: an inlet electrode provided at an ion injection port through which the ion is incident in the collision cell; a voltage generator for applying a direct-current voltage to the inlet electrode; and a voltage controller and a controller for controlling the voltage generator to apply, to the inlet electrode, a direct-current voltage with a polarity same as a polarity of an unnecessary ion generated in the ion source, during at least a part of a standby period of time in which no analysis-target ion is analyzed.
    Type: Grant
    Filed: October 8, 2019
    Date of Patent: July 19, 2022
    Assignee: SHIMADZU CORPORATION
    Inventor: Tomoyoshi Matsushita
  • Patent number: 11387091
    Abstract: A method of ionisation is disclosed in which a sample is heated such that analyte is released from the sample. Analyte released from the sample is accumulated, and then the accumulated analyte is passed to an ionisation region where the analyte is ionised.
    Type: Grant
    Filed: June 20, 2019
    Date of Patent: July 12, 2022
    Assignee: Micromass UK Limited
    Inventors: Stevan Bajic, David Douce, Scott Pritchard
  • Patent number: 11387087
    Abstract: A method, apparatus, and computer-readable storage medium for analyzing component separation/mass spectrometer data for a sample having known characteristic includes analyzing reference ion data for a relationship between ion mass, retention time, and intensity. The analyzed data is added to a repository, wherein each ion therein has an intensity maxima within a characteristic retention time range for a characteristic ion mass. If the reference ion is in the repository, the range is modified according to the characteristic retention time of the reference ion intensity maxima. Based on the known characteristic, an ion expected in the sample is selected from the repository, and sample data is compared to data for the ion selected from the repository to determine whether the ion is present in the sample. The range in the repository is then modified according to the characteristic retention time of the intensity maxima for the ion present in the sample.
    Type: Grant
    Filed: June 12, 2020
    Date of Patent: July 12, 2022
    Assignee: Metabolon, Inc.
    Inventors: William Lefew, David V. Foster, Rex A. Dwyer, Shelby S. Matlock, Casson Stallings, Michael Humphrey, Michael Heiser
  • Patent number: 11371970
    Abstract: The present invention relates to a method for analyzing the molecular weight of each polymer comprised in a polymer compound, and an analysis system used therefor. More specifically, the present invention relates to an analysis method of components of polymer compounds and molecular weight by component using a system in which size-exclusion chromatography (SEC)-pyrolysis gas chromatography (Py-GC)-mass spectrometry (MS) are connected in series and to an analysis system used in the method.
    Type: Grant
    Filed: September 16, 2019
    Date of Patent: June 28, 2022
    Inventors: Rin Jang, Byoung Hyoun Kim
  • Patent number: 11366066
    Abstract: Apparatus include an atmospheric pressure glow discharge (APGD) analyte electrode defining an analyte discharge axis into an APGD volume, and a plurality of APGD counter electrodes having respective electrical discharge ends directed to the APGD volume, wherein the APGD analyte electrode and the APGD counter electrodes are configured to produce an APGD plasma in the APGD volume with a voltage difference between the APGD analyte electrode and one or more of the AGPD counter electrodes. An electrode can be integrated into an ion inlet. Apparatus can be configured to perform auto-ignition and/or provide multi-modal operation through selectively powering electrodes. Electrode holder devices are disclosed. Related methods are disclosed.
    Type: Grant
    Filed: October 11, 2019
    Date of Patent: June 21, 2022
    Assignees: Battelle Memorial Institute, Clemson University Research Foundation, GAA Custom Engineering LLC
    Inventors: David W. Koppenaal, Ying Zhu, Edward D. Hoegg, R. Kenneth Marcus, Gordon A. Anderson, Chris Anderson, Tyler Williams
  • Patent number: 11367604
    Abstract: In an embodiment, a laser ablation system can include a laser ablation cell and at least a pair of particle-collection-to-transport-tubing interfaces. The laser ablation cell can be configured for ablating a sample or another material, and the laser ablation cell can include a laser unit. The at least a pair of particle-collection-to-transport-tubing interfaces can be configured to gather an ablated sample and direct the ablated sample to an analysis unit. A selected particle-collection-to-transport-tubing interface can be received by the laser ablation cell directly above the laser unit. The at least a pair of particle-collection-to-transport-tubing interfaces can be configured to be interchangeable with one another.
    Type: Grant
    Filed: January 11, 2021
    Date of Patent: June 21, 2022
    Assignee: Elemental Scientific Lasers, LLC
    Inventors: Ciaran J. O'Connor, Leif C. Summerfield
  • Patent number: 11361955
    Abstract: A synchronization condition setting processing unit receives a user's selection regarding an MRM transition for which the timing of starting voltage application to a probe is to be synchronized with the timing of starting analysis. A mass spectrometry control unit controls a mass spectrometric unit to repeat a cycle of executing MRM measurement of a plurality of preset MRM transitions, while an ionization control unit controls a PESI ion source to alternately repeat an up-and-down movement of the probe and high voltage application to the probe, and at that time, a synchronization control unit controls control operations of a mass spectrometry control unit and an ionization control unit such that timings of start of the MRM measurement for the MRM transition selected by the user and start of application of voltage to the probe match.
    Type: Grant
    Filed: January 26, 2018
    Date of Patent: June 14, 2022
    Assignee: SHIMADZU CORPORATION
    Inventor: Tasuku Murata
  • Patent number: 11361954
    Abstract: The invention generally relates to systems and methods for conducting reactions and screening for reaction products.
    Type: Grant
    Filed: March 22, 2018
    Date of Patent: June 14, 2022
    Assignee: Purdue Research Foundation
    Inventor: Robert Graham Cooks
  • Patent number: 11355309
    Abstract: The present invention relates to a sensor for electron detection emitted from an object to be used with a charged particle beam column being operated at a certain column and wafer voltage. The sensor is configured and operable to at least reduce interaction of negative ions with the active area of the sensor while minimizing electrons energy loss. The sensor is also configured and operable to minimize both gradual degradation of a cathodoluminescence efficiency of the active area and dynamic change of cathodoluminescence generated during operation of the sensor and evolving throughout the scintillator's lifetime.
    Type: Grant
    Filed: August 1, 2019
    Date of Patent: June 7, 2022
    Assignee: APPLIED MATERIALS ISRAEL LTD.
    Inventors: Itay Assulin, Jacob Levin, Guy Eytan
  • Patent number: 11355334
    Abstract: Methods and systems are provided herein for selectively removing product ions resulting from an ECD dissociation event from the interaction region of an ECD reaction cell, while other precursor peptide ions continue to undergo ECD within the interaction region, thereby reducing or preventing the occurrence of multiple electron capture events by the product ions. In some aspects, the preferential extraction of product ions from the interaction region during the ECD reaction can occur without an auxiliary AC field being generated within the interaction region. Additionally, in some aspects, the methods and systems disclosed herein can subject the various product ions to a non-dissociative charge reduction via exposure to reagent ions of the opposite polarity so as to selectively concentrate product ions to a lower charge state.
    Type: Grant
    Filed: June 20, 2017
    Date of Patent: June 7, 2022
    Assignee: DH Technologies Development Pte. Ltd.
    Inventor: Takashi Baba
  • Patent number: 11348780
    Abstract: An ultrasonic transmitter (95) and detector (e.g., integrated as an ultrasound transducer) utilized in a feedback control system automatically monitors and/or detects surface profile (e.g., shape) of the liquid-air interface and adjusts the flow rate of sampling liquid to ensure that experimental conditions remain consistent at the time of sample introduction during serial samplings. The feedback control can provide for automated adjustment of the surface profile of the liquid-air interface in accordance with changes in desired set point according to an experimental workflow (e.g., automated adjustment between an interface corresponding to a vortex sampling set point and an overflow cleaning set point).
    Type: Grant
    Filed: November 20, 2018
    Date of Patent: May 31, 2022
    Assignee: DH Technologies Development Pte. Ltd.
    Inventors: Don W Arnold, Thomas R. Covey, Chang Liu
  • Patent number: 11346807
    Abstract: There are provided an ion mobility spectrometer and a sniffer. The ion mobility spectrometer includes: an ion migration tube; a sampling gas path having a sampling device configured to temporarily store a sample gas collected by a sampling head in a sampling pipe; a sample introduction gas path having two ends in communication with the gas inlet and outlet of the ion migration tube respectively, and configured to introduce a carrier gas within the ion migration tube into the sampling pipe and to carry a sample gas temporarily stored in the sampling pipe into the ion migration tube; and a valve assembly configured to only allow gas to flow from the sampling device to the sampling pipe in a sampling state, and to only allow gas to flow from the ion migration tube through the sampling pipe back to the ion migration tube in a sample introduction state.
    Type: Grant
    Filed: June 12, 2019
    Date of Patent: May 31, 2022
    Assignee: Nuctech Company Limited
    Inventors: Qingjun Zhang, Yuanjing Li, Zhiqiang Chen, Jianmin Li, Yinong Liu, Yaohong Liu, Lili Yan, Biao Cao, Weiping Zhu, Ge Li, Qiufeng Ma, Qi Mao, Nan Bai
  • Patent number: 11335546
    Abstract: A laser desorption/ionization method, includes: a first step of preparing a sample support body including a substrate on which a plurality of through holes opening to a first surface and a second surface facing each other are formed, a conductive layer provided on at least the first surface, and a solvent provided in the plurality of through holes with refractoriness in a vacuum; a second step of mounting a sample on a mounting surface of a mounting portion, and of disposing the sample support body on the sample such that the second surface is in contact with the sample; and a third step of ionizing a component of the sample that is mixed with the solvent and is moved to the first surface side from the second surface side through the through hole by irradiating the first surface with laser beam while applying a voltage to the conductive layer.
    Type: Grant
    Filed: October 5, 2018
    Date of Patent: May 17, 2022
    Assignee: HAMAMATSU PHOTONICS K.K.
    Inventors: Yasuhide Naito, Takayuki Ohmura, Masahiro Kotani
  • Patent number: 11328915
    Abstract: A mass spectrometry method comprising steps of generating an ion beam from an ion source; directing the ion beam into a collision cell; introducing into the collision cell through a gas inlet on the collision cell a charge-neutral analyte gas or reaction gas; ionizing the analyte gas or reaction gas in the collision cell by means of collisions between the analyte gas or reaction gas and the ion beam; transmitting ions from the ionized analyte gas or reaction gas from the collision cell into a mass analyzer; and mass analyzing the transmitted ions of the ionized analyte or reaction gas. The methods can be applied in isotope ratio mass spectrometry to determine the isotope abundance or isotope ratio of a reaction gas used in mass shift reactions between the gas and sample ions, to determine a corrected isotope abundance or ratio of the sample ions.
    Type: Grant
    Filed: April 23, 2020
    Date of Patent: May 10, 2022
    Assignee: Thermo Fisher Scientific (Bremen) GmbH
    Inventors: Johannes Schwieters, Henning Wehrs, Jamie Lewis
  • Patent number: 11315779
    Abstract: A mass spectrometric system comprises an RF-device for transversely confining ions in an ion region using: (a) a first set of electrodes arranged parallel to one another along a direction of ion travel to define a first transverse boundary of the ion region, and that are supplied with a first RF-voltage such that opposite phases of the first RF-voltage are applied to adjacent electrodes of the first set; and (b) a second set of electrodes arranged parallel to one another along said direction of ion travel to define a second transverse boundary of the ion region, and that are supplied with a second RF-voltage such that opposite phases of the second RF-voltage are applied to adjacent electrodes of the second set, the first and second transverse boundaries being opposite each other in a transverse direction of the ion region and the first and second RF voltages having different frequencies.
    Type: Grant
    Filed: March 22, 2021
    Date of Patent: April 26, 2022
    Inventor: Melvin Andrew Park
  • Patent number: 11315778
    Abstract: Devices, systems and methods including a spray chamber are described. In certain examples, the spray chamber may be configured with an outer chamber configured to provide tangential gas flows. In other instances, an inner tube can be positioned within the outer chamber and may comprise a plurality of microchannels. In some examples, the outer chamber may comprise dual gas inlet ports. In some instances, the spray chamber may be configured to provide tangential gas flow and laminar gas flows to prevent droplet formation on surfaces of the spray chamber. Optical emission devices, optical absorption devices and mass spectrometers using the spray chamber are also described.
    Type: Grant
    Filed: September 18, 2020
    Date of Patent: April 26, 2022
    Assignee: PerkinElmer Health Sciences Canada, Inc.
    Inventors: Chady Stephan, Hamid Badiei, Serguei Savtchenko, Samad Bazargan
  • Patent number: 11304637
    Abstract: The invention generally relates to enclosed desorption electrospray ionization probes, systems, and methods. In certain embodiments, the invention provides a source of DESI-active spray, in which a distal portion of the source is enclosed within a transfer member such that the DESI-active spray is produced within the transfer member.
    Type: Grant
    Filed: October 9, 2020
    Date of Patent: April 19, 2022
    Assignee: Purdue Research Foundation
    Inventors: Robert Graham Cooks, Zheng Ouyang, Chien-hsun Chen, Ziqing Lin, Livia Schiavinato Eberlin
  • Patent number: 11293422
    Abstract: A system comprises: a vacuum chamber disposed within a housing and having a vacuum port; a vacuum pump within the housing and having a gas inlet port that is fluidically coupled to the vacuum port; and a fluid circuit that comprises: one or more fluidic tubing lines, channels or conduits in thermal contact with a housing of the vacuum pump; a liquid pump fluidically coupled to an inlet of the one or more fluidic tubing lines, channels or conduits; and a heat exchanger having a heat exchanger inlet and a heat exchanger outlet, wherein the heat exchanger inlet is fluidically coupled to an outlet of the one or more fluidic tubing lines, channels or conduits and the heat exchanger outlet is fluidically coupled to the liquid pump. The fluid circuit may also include a portion that is in thermal contact with the vacuum chamber.
    Type: Grant
    Filed: August 2, 2019
    Date of Patent: April 5, 2022
    Assignee: THERMO FINNIGAN LLC
    Inventors: Jaime A. Carrera, Dustin J. Kreft
  • Patent number: 11287414
    Abstract: The invention generally relates to a sample dispenser including an internal standard and methods of use thereof.
    Type: Grant
    Filed: July 23, 2020
    Date of Patent: March 29, 2022
    Assignee: Purdue Research Foundation
    Inventors: Zheng Ouyang, He Wang, Nicholas E. Manicke, Robert Graham Cooks, Qian Yang, Jiangjiang Liu
  • Patent number: 11287402
    Abstract: An analytical system including a mass spectrometer (MS) coupled to liquid chromatography (LC) via an ionization source (IS), and an automated method of maintaining the analytical system in a QC-compliant status are described. The method comprises determining a deviation of the analytical system from a QC-compliant status by determining a deviation of one or more predetermined parameters in an m/z spectrum above one or more predetermined thresholds, triggering an IS and/or MS maintenance procedure upon determining a deviation from the QC-compliant status, determining a return or a failed return to the QC-compliant status during and/or after the IS and/or MS maintenance procedure by determining a return or a failed return respectively of the one or more predetermined parameters in an m/z spectrum below the one or more predetermined thresholds, triggering another IS and/or MS maintenance procedure upon determining a failed return to the QC-compliant status.
    Type: Grant
    Filed: December 7, 2020
    Date of Patent: March 29, 2022
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Stefan Quint, Marian Roetzer, Florian Schweinberger, Benjamin Tiemann, Marius Wagner, Ralf Zimmermann
  • Patent number: 11282691
    Abstract: A method of ionizing a sample is disclosed that comprises heating a sample so that analyte is released from the sample, producing charged particles such as charged droplets downstream of the sample, and using the charged particles to ionize at least some of the analyte released from the sample so as to produce analyte ions.
    Type: Grant
    Filed: December 21, 2018
    Date of Patent: March 22, 2022
    Assignee: Micromass UK Limited
    Inventors: Stevan Bajic, David S. Douce
  • Patent number: 11275029
    Abstract: A laser-ablation-based analytical system can include a sample chamber input, a make-up gas input, a vacuum pump, and an output flow. The sample chamber input can be configured to deliver a sample chamber gas flow comprised of combination of a laser-ablated sample and a sample-carrier gas from a sample chamber. The make-up gas input can be configured to provide an amount of make-up gas to supplement the combination of the laser-ablated sample and the sample-carrier gas. The vacuum pump can be fluidly connected to the sample chamber input and the make-up gas input, the vacuum pump configured to create a negative pressure in a sample transport gas downstream of the vacuum pump, the sample transport gas including the make-up gas, the laser-ablated sample, and the sample-carrier gas. The output flow can be configured to deliver the sample transport gas from the vacuum pump to a detection device.
    Type: Grant
    Filed: December 6, 2019
    Date of Patent: March 15, 2022
    Assignee: ELEMENTAL SCIENTIFIC LASERS, LLC
    Inventors: Robert W. Hutchinson, David N. Douglas
  • Patent number: 11264226
    Abstract: Disclosed herein is an ion guide for guiding an ion beam along an ion path, said ion guide having a longitudinal axis which corresponds to said ion path. Said ion guide comprises a plurality of electrode plates which are arranged perpendicularly to the longitudinal axis, each electrode plate having an opening and being arranged such that said longitudinal axis extends through its respective opening, wherein said openings collectively define an ion guide volume. The ion guide extends or is configured to extend through a separation wall separating adjacent first and second pumping chambers. The ion guide has a first portion, in which gaps are formed between at least some of said electrode plates such that uncharged gas can escape from said ion guide volume, wherein said first portion is completely located in said first pumping chamber.
    Type: Grant
    Filed: April 5, 2019
    Date of Patent: March 1, 2022
    Assignee: TECHNISCHE UNIVERSITÄT MÜNCHEN
    Inventors: Tobias Kaposi, Hartmut Schlichting, Johannes Barth, Andreas Walz
  • Patent number: 11264221
    Abstract: The present invention relates to the high resolution imaging of samples using imaging mass spectrometry (IMS) and to the imaging of biological samples by imaging mass cytometry (IMCTM) in which labelling atoms are detected by IMS. LA-ICP-MS (a form of IMS in which the sample is ablated by a laser, the ablated material is then ionised in an inductively coupled plasma before the ions are detected by mass spectrometry) has been used for analysis of various substances, such as mineral analysis of geological samples, analysis of archaeological samples, and imaging of biological substances. However, traditional LA-ICP-MS systems and methods may not provide high resolution. Described herein are methods and systems for high resolution IMS and IMC.
    Type: Grant
    Filed: June 18, 2019
    Date of Patent: March 1, 2022
    Assignee: FLUIDIGM CANADA INC.
    Inventors: Paul Corkum, Alexander V. Loboda
  • Patent number: 11257654
    Abstract: To provide an ion milling apparatus adapted to suppress the contamination of a beam forming electrode. The ion milling apparatus includes: an ion gun containing therein a beam forming electrode for forming an ion beam; a specimen holder for fixing a specimen to be processed by irradiation of an ion beam; a mask for shielding a part of the specimen from the ion beam; and an ion gun controller for controlling the ion gun.
    Type: Grant
    Filed: July 14, 2016
    Date of Patent: February 22, 2022
    Assignee: HITACHI HIGH-TECH CORPORATION
    Inventors: Kengo Asai, Hiroyasu Shichi, Toru Iwaya, Hisayuki Takasu
  • Patent number: 11249059
    Abstract: An automated method of monitoring a state of an analyzer is provided including a mass spectrometer (MS) with an electrospray ionization (ESI) source coupled to a liquid chromatography (LC) stream, including monitoring an electrospray ionization current of the ESI source and identifying a condition of multiple conditions of the analyzer based on the monitored ionization current of the ESI source, one of the conditions being a presence of a dead volume in a liquid chromatography stream of the analyzer downstream of an LC column of the LC stream.
    Type: Grant
    Filed: August 14, 2020
    Date of Patent: February 15, 2022
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Stefan Quint, Benjamin Tiemann, Florian Schweinberger, Martin Stingl
  • Patent number: 11251032
    Abstract: A sample support body is a sample support body for ionizing a sample, including: a substrate having an irregular porous structure formed to communicate a first surface and a second surface opposite to each other; and a conductive layer provided at least on the first surface.
    Type: Grant
    Filed: November 30, 2018
    Date of Patent: February 15, 2022
    Assignee: HAMAMATSU PHOTONICS K.K.
    Inventors: Masahiro Kotani, Takayuki Ohmura, Takamasa Ikeda
  • Patent number: 11239065
    Abstract: Method and devices are provided for assessing tissue samples from a plurality of tissue sites in a subject using molecular analysis. In certain aspects, devices of the embodiments allow for the collection of liquid tissue samples and delivery of the samples for mass spectrometry analysis.
    Type: Grant
    Filed: November 30, 2020
    Date of Patent: February 1, 2022
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Livia Schiavinato Eberlin, Thomas Milner, Jialing Zhang, John Lin, John Rector, Nitesh Katta, Aydin Zahedivash
  • Patent number: 11222778
    Abstract: An electrospray ion source for a mass spectrometer comprises: (i) a plurality of N electrospray emitters within an ionization compartment, wherein N?2; (ii) a mixing chamber; (iii) a plurality of N inlets, each inlet comprising a conduit configured to receive charged particles from a respective one of the electrospray emitters and to emit the charged particles into the mixing chamber; (iv) an outlet port either facing or within an intermediate-vacuum compartment; and (v) a heater in thermal contact with at least a portion of the mixing chamber.
    Type: Grant
    Filed: October 30, 2019
    Date of Patent: January 11, 2022
    Assignee: THERMO FINNIGAN LLC
    Inventors: Viatcheslav V. Kovtoun, Eloy R. Wouters
  • Patent number: 11219393
    Abstract: A method for analyzing biological samples using mass spectrometry or ion mobility spectrometry that includes producing gas-phase ions and neutrals from the sample in a proximity of the sample; transferring the produced ions from the sample to a distance via a flexible or re-configurable ion transfer device such that the flexible or re-configurable ion transfer device includes a plurality of electrodes configured to be flexible or flexibly connected to each other, and the ion transfer device is configured to be flexible while transferring the ions to allow the ion transfer device to form one or more curvatures; and separating the produced ions with a mass spectrometer or a mobility analyzer located at the distance to provide spectrometric results.
    Type: Grant
    Filed: July 11, 2019
    Date of Patent: January 11, 2022
    Assignee: Trace Matters Scientific LLC
    Inventor: Mazdak Taghioskoui
  • Patent number: 11215589
    Abstract: A multivariate analysis operation unit (43) represents each of chromatogram data at a specific wavelength ?1 in data acquired by a PDA detector (2) and mass spectrum data repeatedly obtained by a mass spectrometer (3) in the form of a matrix, and then calculates a regression coefficient matrix by performing a PLS operation with a two-dimensional matrix based on the mass spectrum data as an explanatory variable and a one-dimensional matrix based on the chromatogram data as an explained variable. A regression coefficient is obtained with respect to each m/z value, and an m/z value having a high regression coefficient indicates an m/z value of which the chromatogram wavelength at a specific wavelength is similar to an extracted ion chromatogram (XIC). Accordingly, an m/z-value extracting unit (44) compares the regression coefficient with a threshold and extracts a significant m/z value, and an XIC creating unit (46) creates an XIC of the extracted m/z value.
    Type: Grant
    Filed: November 9, 2016
    Date of Patent: January 4, 2022
    Assignee: SHIMADZU CORPORATION
    Inventor: Shinichi Yamaguchi
  • Patent number: 11204337
    Abstract: The invention relates to a method for targeted analysis of ions according to mobility which uses a trapping ion mobility separator (TIMS) comprising a gas flow and an electric DC field barrier within an RF ion guide. The method comprises the steps of introducing ions into the trapping ion mobility separator, pushing the ions by the gas flow against the counteracting electric DC field barrier wherein the height of the electric DC field barrier and the velocity of the gas flow are set such that target ions are trapped near a plateau of the trapping ion mobility separator along which the effective force acting on the ions is substantially constant, and adjusting the height of the electric DC field barrier and/or the velocity of the gas flow in a single step such that the target ions pass the electric DC field barrier.
    Type: Grant
    Filed: May 30, 2019
    Date of Patent: December 21, 2021
    Inventor: Mark Ridgeway
  • Patent number: 11201041
    Abstract: A photomultiplier includes a housing including a proximal end and a distal end, an optical window disposed at the proximal end of the housing, an end-wall plate disposed at the distal end of the housing, a feedthrough that penetrates through the end-wall plate, and a gas electron multiplier (GEM) board disposed between the optical window and the end-wall plate.
    Type: Grant
    Filed: January 26, 2021
    Date of Patent: December 14, 2021
    Assignee: BAKER HUGHES HOLDINGS LLC
    Inventors: Kevin Scott McKinny, Casey Hale, Christopher Freeman, Jonas Burke, Matthew Steinhart, Matthew Mcpheeters
  • Patent number: 11189477
    Abstract: Systems and methods for atmospheric pressure chemical ionization are provided herein. In various aspects, the APCI apparatus, systems, and methods can provide an asymmetric sample spray into a vaporization chamber asymmetrically (e.g., off axis from the longitudinal axis of the vaporization chamber) so as to increase the interaction of the molecules in the sample spray with the vaporization chamber's sidewalls (and expose more of the molecules to the heat generated thereby), which can thereby result in improved consistency and/or efficiency of ion formation, and/or increased sensitivity relative to conventional APCI techniques.
    Type: Grant
    Filed: August 10, 2018
    Date of Patent: November 30, 2021
    Assignee: DH Technologies Development Pte. Ltd.
    Inventors: Thomas R. Covey, Peter Kovarik
  • Patent number: 11183378
    Abstract: In a laser assisted spectroscopy system, an apparatus for bypassing the fluid conduit and a method of bypassing the fluid conduit, opening the sample chamber and replacing the sample, closing and purging the sample chamber, and removing the fluid conduit bypass and returning to online status is addressed by the present disclosure.
    Type: Grant
    Filed: June 5, 2019
    Date of Patent: November 23, 2021
    Assignee: ELEMENTAL SCIENTIFIC LASERS, LLC
    Inventors: Jay N. Wilkins, Leif C. Summerfield, Shane Hilliard, Ciaran J. O'Connor
  • Patent number: 11164735
    Abstract: The invention provides an ion mobility analyzer apparatus and analysis method. The analyzer apparatus includes an ion source, two groups of parallel electrodes, a power supply unit and a detector. The drift region is formed between the two groups of parallel electrodes, and has an ion entrance connected to the ion source and an ion exit. Each group of parallel electrodes is located in a plane respectively, and the two planes are parallel to each other. The power supply unit is configured to apply direct current potentials on the two groups of parallel electrodes to form a direct current electric field that applies an opposing force on ions against the gas flow so that ions with different mobilities are trapped under the combined effect of the gas flow and the direct current electric field. The detector is connected to the ion exit to detect ions.
    Type: Grant
    Filed: June 15, 2018
    Date of Patent: November 2, 2021
    Assignee: SHIMADZU RESEARCH LABORATORY (SHANGHAI) CO., LTD.
    Inventors: Kent James Gillig, Keke Wang, Wenjian Sun, Xiaoqiang Zhang, Yupeng Cheng
  • Patent number: 11152925
    Abstract: A method of performing a computational process using a quantum computer includes generating a laser pulse sequence comprising a plurality of laser pulse segments used to perform an entangling gate operation on a first trapped ion and a second trapped ion of a plurality of trapped ions that are aligned in a first direction, each of the trapped ions having two frequency-separated states defining a qubit, and applying the generated laser pulse sequence to the first and second trapped ions. Each of the plurality of laser pulse segments has a pulse shape with ramps formed using a spline at a start and an end of each of the plurality of laser pulse segments.
    Type: Grant
    Filed: August 11, 2020
    Date of Patent: October 19, 2021
    Assignee: IONQ, INC.
    Inventors: Shantanu Debnath, Jason M. Amini, Jwo-Sy Chen, Neal Pisenti
  • Patent number: 11133170
    Abstract: A solution-cathode glow discharge mass spectrometry (SCGD-MS) apparatus comprises a SCGD source and a mass spectrometer. The SCGD source may comprise conductive rods, a power source, and a capillary. A method for ionizing an analyte comprises flowing an electrically conductive liquid onto a conductive rod, applying an electric potential to a second conductive rod such that a plasma discharge forms between the first conductive rod and the electrically conductive liquid to produce ions, and separating the ions in a mass spectrometer. The analyte may be a polypeptide that may be contacted with trypsin. The analyte may be a solid, liquid, gas, chemical complex, or ion in solution. The method may comprise sequencing the polypeptide.
    Type: Grant
    Filed: August 19, 2020
    Date of Patent: September 28, 2021
    Assignees: Indiana University Research and Technology Corporation, Kent State University
    Inventors: Jacob T. Shelley, Kelsey L. Williams, Gary M. Hieftje, Andrew J. Schwartz
  • Patent number: 11133160
    Abstract: Systems, methods, and devices to dissociate ions using one or more light emitting diodes (LEDs). A mass spectrometer for ion dissociation includes an ion source for providing ions for dissociation, a mass analyzer, and a photodissociation (PD) device. The PD device includes an ion transport device. The ion transport device is configured perform one or more of: transporting the ions through the PD device, and trapping the ions within a region of the PD device. The PD device also includes one or more LEDs positioned to irradiate the ions in the PD device, resulting in fragmentation of the ions.
    Type: Grant
    Filed: June 2, 2017
    Date of Patent: September 28, 2021
    Assignees: BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM, THERMO FISHER SCIENTIFIC (BREMEN) GMBH, THERMO FINNIGAN LLC
    Inventors: Dustin D. Holden, Jens Griep-Raming, Alexander A. Makarov, Jennifer S. Brodbelt, Yevgeniy Zhuk, Jae C. Schwartz
  • Patent number: 11133169
    Abstract: Apparatus is disclosed comprising a first ion source (210) arranged and adapted to emit a spray of charged droplets (211) and a detector or sensor (203) arranged and adapted automatically to detect, sense or determine one or more first parameters or properties of the spray of charged droplets (211) as the spray of charged droplets (211) impacts upon a surface of the detector or sensor 203. The apparatus further comprises a control system (204) arranged and adapted to adjust, correct and/or optimise one or more second parameters or properties of the spray of charged droplets (211) based on the one or more first parameters or properties of the spray of charged droplets (211) detected, sensed or determined by the detector or sensor (203).
    Type: Grant
    Filed: June 5, 2017
    Date of Patent: September 28, 2021
    Assignee: Micromass UK Limited
    Inventors: Emrys Jones, Richard Chapman, Steven Pringle
  • Patent number: 11133146
    Abstract: A solution electrode glow discharge apparatus has a housing that contains a solid electrode. The solid electrode has a head and a tip. The tip of the solid electrode extends outwards from the housing. At least a portion of the head of the solid electrode is positioned with an electrical and thermal conducting block. An adjustable-polarity power supply is provided in communication with the solid electrode. A cooling mechanism is provided for cooling the electrical and thermal conducting block.
    Type: Grant
    Filed: June 5, 2020
    Date of Patent: September 28, 2021
    Assignee: 2S WATER INCORPORATED
    Inventors: Neil Johnson, Ander Palmgren
  • Patent number: 11120981
    Abstract: A laser desorption/ionization method includes: a first process of preparing a sample support body that includes a substrate in which a plurality of through-holes are formed and a conductive layer that is provided on the first surface of the substrate; a second process of mounting a frozen sample on a mounting surface of a mount under a sub-freezing atmosphere, and fixing the sample support body to the mount in a state in which the second surface is in contact with the frozen sample; a third process of thawing the sample, and moving components of the thawed sample toward the first surface via the plurality of through-holes due to a capillary phenomenon; and a fourth process of irradiating the first surface with a laser beam while applying a voltage to the conductive layer, and ionizing the components that have moved toward the first surface.
    Type: Grant
    Filed: July 31, 2018
    Date of Patent: September 14, 2021
    Assignee: HAMAMATSU PHOTONICS K.K.
    Inventors: Masahiro Kotani, Takayuki Ohmura
  • Patent number: 11114290
    Abstract: An ion transport system comprises: (I) an ion transfer tube extending between an atmospheric-pressure ionization chamber and a partially evacuated chamber; and (II) an ion funnel within the chamber comprising: (1) an exit electrode that has an exit aperture configured to deliver the gas and charged particles to a high-vacuum chamber; and (2) a funnel portion comprising a plurality of plate electrodes configured as a stack, each electrode comprising a respective aperture, wherein an aperture diameter of each of the plurality of electrodes is greater than or equal to three times an inter-electrode pitch and wherein no DC electrical potential gradient is applied between the exit electrode and an adjacent one of the plurality of plate electrodes.
    Type: Grant
    Filed: May 7, 2020
    Date of Patent: September 7, 2021
    Assignees: THERMO FINNIGAN LLC, Thermo Fisher Scientific (Bremen) GmbH
    Inventors: Joshua A. Silveira, Eloy R. Wouters, Alexander A. Makarov, Mikhail G. Skoblin, Viacheslav I. Kozlovskiy
  • Patent number: 11107669
    Abstract: A system and method for sample analysis using sub-atmospheric pressure (sub-AP) laser ionization. The sub-AP ion source includes a holder with a sample containing analyte molecules, a pulsed laser beam configured to generate ionized species from the sample, an ion extractor adjacent to the holder configured to extract analyte ions from the ionized species by an extraction electric field Es near the sample, an ion funnel structure composed of orifice electrodes located along an ion funnel pathway direction z. The ion funnel structure has an entrance and an exit, the exit being the electrode with the smallest aperture in the structure. This structure is configured for accepting the analyte ions from the ion extractor at the entrance and dragging them toward the exit using an axial electric field Ez along the direction z. The extraction electric field Es is at least partly electrically shielded from the axial electric field Ez.
    Type: Grant
    Filed: September 5, 2018
    Date of Patent: August 31, 2021
    Assignee: SCIENCE AND ENGINEERING SERVICES, LLC
    Inventors: Vladimir M. Doroshenko, Victor V. Laiko, Eugene Moskovets