With Sample Supply Means Patents (Class 250/288)
  • Patent number: 10991562
    Abstract: An ion source for a mass spectrometer is disclosed comprising an ultrasonic transducer which focuses ultrasonic energy onto a surface of a sample fluid without directly contacting the sample fluid.
    Type: Grant
    Filed: July 22, 2019
    Date of Patent: April 27, 2021
    Assignee: Micromass UK Limited
    Inventors: Michael Raymond Morris, Steven Derek Pringle, Keith Richardson, Ian Sinclair
  • Patent number: 10991560
    Abstract: A method of mass or ion mobility spectrometry is disclosed that uses the Leidenfrost effect to cause a liquid to be repelled away from a heated surface so as to levitate above there-above. The repelled liquid is urged so as to move along the surface in a predetermined direction, for example, by the geometric configuration of the heated surface.
    Type: Grant
    Filed: May 30, 2019
    Date of Patent: April 27, 2021
    Assignee: Micromass UK Limited
    Inventors: Jeffery Mark Brown, Steve Bajic, Steven Derek Pringle
  • Patent number: 10989690
    Abstract: The invention is related to a trapped ion mobility spectrometer (TIMS device) and proposes to use higher order (order N>2) linear multipole RF systems to accumulate and analyze ions at an electric DC field barrier, either pure higher order RF multipole systems or multipole RF systems with transitions from higher order towards lower order, e.g. from a linear octopolar RF system (N=4) to a linear quadrupole RF system (N=2) in front of the apex of the electric DC field barrier.
    Type: Grant
    Filed: October 16, 2019
    Date of Patent: April 27, 2021
    Inventors: Oliver Räther, Thomas Betz, Melvin Andrew Park
  • Patent number: 10991558
    Abstract: This invention relates to graphical user-interactive displays for use in MS-based analysis of protein impurities, as well as methods and software for generating and using such. One aspect provides a user-interactive display comprising interactive and dynamic selection of one or more masses and concurrent display of peaks (points) corresponding to that predicted mass value across other displays (MS1, deconvolved mass spectrum, etc.).
    Type: Grant
    Filed: January 27, 2020
    Date of Patent: April 27, 2021
    Assignee: Protein Metrics Inc.
    Inventors: Marshall Bern, Yong Joo Kil
  • Patent number: 10991563
    Abstract: An apparatus for molecular imaging of biological samples includes a first optical port configured to receive a first pulsed optical beam that is directed in an optical path along an optical axis. A transparent target that include a first surface having an electrically conductive surface that supports a biological sample under analysis and a second surface is positioned in the optical path along the optical axis. A moveable target mount is configured to translate the transparent target to a plurality of predetermined locations. A first optical focusing element is configured to focus the first pulsed optical beam to a first predetermined diameter at the first surface of the transparent target. A second optical port is configured to receive a second pulsed optical beam that is directed in a second optical path along the optical axis.
    Type: Grant
    Filed: August 27, 2019
    Date of Patent: April 27, 2021
    Assignee: Virgin Instruments Corporation
    Inventors: Marvin L. Vestal, Kevin Hayden
  • Patent number: 10991565
    Abstract: Provided is an ion analyzer characterized by: an ionization chamber (10) to be maintained at atmospheric pressure; an analysis chamber (11) for analyzing an ion generated in the ionization chamber (10); a vacuum pump (15, 16) for evacuating the inside of the analysis chamber (11); a capillary (102) for allowing the ionization chamber (10) and the analysis chamber (11) to communicate with each other; a conductance changer (103, 104) for changing the conductance of the capillary (102); and a controller (20) for operating the conductance changer (103, 104) in such a manner as to decrease the conductance of the capillary (102) when the degree of vacuum in the analysis chamber (11) is lower than a predetermined degree of vacuum.
    Type: Grant
    Filed: December 17, 2015
    Date of Patent: April 27, 2021
    Assignee: SHIMADZU CORPORATION
    Inventor: Wataru Fukui
  • Patent number: 10985004
    Abstract: A mass spectrometer (10) includes a housing (19) that houses a plurality of devices including a mass analyzer (110) including an ionization unit, a mass separation unit, and an ion detection unit, a first heat generation device (11), and a second heat generation device (12) which has an allowable maximum temperature lower than that of the first heat generation device (11) or an allowable temperature variation amount smaller than that of the first heat generation device (11), an intake port (14) of the housing (19) which is provided at a position closer to the second heat generation device (12) with respect to the first heat generation device (11), and an exhaust fan (15) of the housing (19) which is provided at a position farther from the second heat generation device (12) with respect to the first heat generation device (11).
    Type: Grant
    Filed: July 18, 2017
    Date of Patent: April 20, 2021
    Assignee: SHIMADZU CORPORATION
    Inventor: Tomoya Kudo
  • Patent number: 10978282
    Abstract: A liquid sample introduction system for a plasma spectrometer includes a sample container for holding a liquid sample, a surface acoustic wave (SAW) nebulizer, arranged to receive a liquid sample from the sample container, an electronic controller for supplying electrical power to the SAW nebulizer so as to produce a surface acoustic wave on a surface of the SAW nebulizer, for generating an aerosol from the supplied sample liquid, and an aerosol transport arrangement for receiving the aerosol from the SAW nebulizer and carrying it into a plasma or flame of a spectrometer. The electronic controller is further configured to control the electrical power to the SAW nebulizer so as to permit adjustment of the aerosol parameters, and to control the aerosol transport arrangement so as to permit adjustment of the aerosol delivery into the plasma or flame of the spectrometer.
    Type: Grant
    Filed: December 7, 2016
    Date of Patent: April 13, 2021
    Assignee: Thermo Fisher Scientific (Bremen) GMBH
    Inventor: Ayrat Murtazin
  • Patent number: 10978849
    Abstract: A high-power laser beam with an arbitrary intensity profile is produced. Such beam has a variety of uses including for laser materials processing such as powder bed fusion additive manufacturing. Several challenges in additive manufacturing are mitigated with the present non-uniform intensity laser profiles. Nonuniform shapes include a set of intensity pixels in a line that could print a wide stripe area instead of just a single line. One example uses the multimode interference pattern from the output of a ribbon fiber which is imaged onto a work piece. The interference pattern is controlled to allow turning on or off of ‘pixels’ along a line which can be used to shape the beam and form the additively manufactured part.
    Type: Grant
    Filed: January 31, 2019
    Date of Patent: April 13, 2021
    Assignee: LAWRENCE LIVERMORE NATIONAL SECURITY, LLC
    Inventors: Derrek R. Drachenberg, Jay W. Dawson, Gabriel M. Guss, Paul H. Pax, Alexander M. Rubenchik, Manyilibo J. Matthews
  • Patent number: 10978289
    Abstract: A method of fragmenting ions comprises: injecting first ions of a first charge into an ion trap that includes an elongate multipole electrode assembly defining an elongate ion channel; radially confining the first ions within the ion channel by applying an RF pseudopotential to the electrode assembly and axially confining said ions to a first volume within the ion channel by applying a first potential well to the ion channel; injecting second ions of a second charge opposite to the first charge into the ion trap; axially confining the second ions to a second volume within the ion channel by applying a second potential well to the ion channel, the first potential well being within the second potential well; cooling the first and second ions in the ion trap; and allowing the ions to interact such that the first ions and/or second ions are fragmented to produce product ions.
    Type: Grant
    Filed: October 23, 2018
    Date of Patent: April 13, 2021
    Assignee: Thermo Fisher Scientific (Bremen) GmbH
    Inventor: Hamish Stewart
  • Patent number: 10971348
    Abstract: Disclosed herein is an apparatus for supplying reagent ions, for example ETD or PTR reagent ions, to a mass spectrometer. The apparatus includes a reagent material reservoir, coupled to a carrier gas supply, which delivers an entrained reagent vapor flow to an inlet of a mixing junction through a first flow restrictor. A control gas flow of carrier gas is delivered to another inlet of the mixing junction via a variable pressure regulator and a second flow restrictor. The outlet of the mixing junction is coupled via a third flow restrictor and a reagent transfer junction to an inlet of an ionizer, such as a glow-discharge ionizer. By dynamic adjustment of the output pressure of the variable pressure regulator, the flow rate of reagent vapor may be controlled over a broad range, even for reagent materials of relatively high volatility.
    Type: Grant
    Filed: July 11, 2018
    Date of Patent: April 6, 2021
    Assignee: Thermo Finnigan
    Inventor: Christopher Mullen
  • Patent number: 10960341
    Abstract: An air filter including a filter support that supports polymeric sorbent particles. The polymeric sorbent is the reaction product of a divinylbenzene/maleic anhydride precursor polymeric material with a nitrogen-containing compound.
    Type: Grant
    Filed: March 10, 2017
    Date of Patent: March 30, 2021
    Assignee: 3M Innovative Properties Company
    Inventors: Michael S. Wendland, Michael W. Kobe, Himanshu Jasuja, Andrew R. Fox
  • Patent number: 10930488
    Abstract: A mass spectrometer, includes: a sampling probe that irradiates a specimen disposed in the atmosphere with an electron and obtains a sample separated from the specimen; and a measurement unit that performs mass spectrometry of the sample obtained by the sampling probe, wherein the sampling probe comprises: a casing having an opening which is opened to the atmosphere and an outlet through which the sample is discharged to the measurement unit; and a surface emission type electron emission element housed in the casing such that an electron emission surface thereof opposes to the opening.
    Type: Grant
    Filed: March 10, 2020
    Date of Patent: February 23, 2021
    Assignee: SHIMADZU CORPORATION
    Inventors: Osamu Furuhashi, Tomomi Tamura, Kiyoshi Ogawa
  • Patent number: 10919285
    Abstract: A method for inspection of additive manufactured parts and monitoring operational performance of an additive manufacturing apparatus is provided. The method includes a step of obtaining, in real-time during an additively manufactured build process, a backscatter x-ray scan of an area of a build platform. The build platform is configured for supporting at least one part during the build process. An evaluating step evaluates, by a processor, the backscatter x-ray scan. A determining step determines, based on the evaluating, whether an operational flaw with the additive manufacturing apparatus has occurred or a defect in the at least one part has occurred. A backscatter x-ray system has an emitter that emits x-rays and a detector that receives backscattered x-rays. The emitter and detector are located on a movable support located above the build platform, and the movable support raises and lowers the emitter and detector with respect to the build platform.
    Type: Grant
    Filed: November 7, 2016
    Date of Patent: February 16, 2021
    Assignee: General Electric Company
    Inventors: Ehsan DehghanNiri, Srikanth Chandrudu Kottilingam, Claude Leonard Going, Jr.
  • Patent number: 10923338
    Abstract: The invention generally relates to apparatuses for focusing ions at or above ambient pressure and methods of use thereof. In certain embodiments, the invention provides an apparatus for focusing ions that includes an electrode having a cavity, at least one inlet within the electrode configured to operatively couple with an ionization source, such that discharge generated by the ionization source is injected into the cavity of the electrode, and an outlet. The cavity in the electrode is shaped such that upon application of voltage to the electrode, ions within the cavity are focused and directed to the outlet, which is positioned such that a proximal end of the outlet receives the focused ions and a distal end of the outlet is open to ambient pressure.
    Type: Grant
    Filed: August 7, 2020
    Date of Patent: February 16, 2021
    Assignee: Purdue Research Foundation
    Inventors: Robert Graham Cooks, Zane Baird, Wen-Ping Peng
  • Patent number: 10916415
    Abstract: An apparatus for mass spectrometry and/or ion mobility spectrometry is disclosed comprising a first device arranged and adapted to generate aerosol, smoke or vapor from a target and one or more second devices arranged and adapted to aspirate aerosol, smoke, vapor and/or liquid to or towards an analyzer. A liquid trap or separator is provided to capture and/or discard liquid aspirated by the one or more second devices.
    Type: Grant
    Filed: March 7, 2016
    Date of Patent: February 9, 2021
    Assignee: Micromass UK Limited
    Inventors: Tamas Karancsi, Lajos Godorhazy, Daniel Szalay, Zoltan Takats, Julia Balog, Steven Derek Pringle, Daniel Simon
  • Patent number: 10914713
    Abstract: This disclosure provides quantitative, rapid, and reliable LC-MS/MS methods for analyzing panels of pesticides and mycotoxins in various samples, including very hydrophobic and chlorinated compounds normally analyzed on a GC-MS/MS system. The methods can be carried out using a single instrument and can detect and quantify levels of the pesticides and mycotoxins that are well below action limits specified by U.S. states (e.g., California) and other countries (e.g., Canada) for these compounds in cannabis products.
    Type: Grant
    Filed: January 23, 2019
    Date of Patent: February 9, 2021
    Assignee: PerkinElmer Health Sciences, Inc.
    Inventor: Avinash Dalmia
  • Patent number: 10910208
    Abstract: Systems and approaches for semiconductor metrology and surface analysis using Secondary Ion Mass Spectrometry (SIMS) are disclosed. In an example, a secondary ion mass spectrometry (SIMS) system includes a sample stage. A primary ion beam is directed to the sample stage. An extraction lens is directed at the sample stage. The extraction lens is configured to provide a low extraction field for secondary ions emitted from a sample on the sample stage. A magnetic sector spectrograph is coupled to the extraction lens along an optical path of the SIMS system. The magnetic sector spectrograph includes an electrostatic analyzer (ESA) coupled to a magnetic sector analyzer (MSA).
    Type: Grant
    Filed: April 23, 2020
    Date of Patent: February 2, 2021
    Assignee: NOVA MEASURING INSTRUMENTS, INC.
    Inventors: David A. Reed, Bruno W. Schueler, Bruce H. Newcome, Rodney Smedt, Chris Bevis
  • Patent number: 10910204
    Abstract: A cleanliness monitor for monitoring a cleanliness of a vacuum chamber. The cleanliness monitor may include a mass spectrometer, a molecule aggregation and release unit and an analyzer. The molecule aggregation and release unit is configured to (a) aggregate, during an aggregation period, organic molecules that are present in the vacuum chamber and (b) induce, during a release period, a release of a subset of the organic molecules towards the mass spectrometer. The mass spectrometer is configured to monitor an environment within the vacuum chamber and to generate detection signals indicative of a content of the environment; wherein a first subset of the detection signals is indicative of a presence of the subset of the organic molecules. The analyzer is configured to determine the cleanliness of the vacuum chamber based on the detection signals.
    Type: Grant
    Filed: September 19, 2019
    Date of Patent: February 2, 2021
    Assignee: Applied Materials Israel Ltd.
    Inventors: Irit Ruach-Nir, Michal Eilon, Guy Eytan, Magen Yaacov Schulman
  • Patent number: 10903045
    Abstract: The disclosed technology relates to a method and apparatus for atomic probe tomography (APT). The APT relates to the 3-dimensional reconstruction of the material of a sample having a free-standing tip, wherein an image is repeatedly obtained of the tip area through ptychography or ankylography, in the course of the APT analysis. In one aspect, imaging of the tip is achieved by directing a coherent light beam in the soft X-ray energy range at the tip during the APT analysis. The photons of the X-ray beam are not affected by the strong electric field around the tip, and thereby allow to determine the image of the tip through the application of a ptychography or ankylography algorithm to the data obtained from a photon detector. The photon detector is positioned to detect interference patterns created by photons which have interacted with the tip area, at different overlapping spots of the tip area, when the X-ray beam is scanned across a plurality of such overlapping areas.
    Type: Grant
    Filed: February 20, 2019
    Date of Patent: January 26, 2021
    Assignee: IMEC vzw
    Inventor: Paul van der Heide
  • Patent number: 10886117
    Abstract: The invention is a method for capturing biological species present in a body tissue. The method comprises an arrangement of tissue on a support, referred to as a capture support, capable of selectively capturing one or more biological species, referred to as species of interest. The method comprises; —a step of depositing a lysis reagent on the tissue; —a step of droplet formation, on the surface of the tissue, each droplet comprising the solubilized lysis reagent; —a formation of lysis sites, in the tissue, between each droplet and the capture support, such that at each lysis site, species of interest are freed and captured by the capture support.
    Type: Grant
    Filed: December 13, 2017
    Date of Patent: January 5, 2021
    Assignee: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
    Inventors: Adrien Mombrun, Mohamed-Ali Bouamrani, Celine Le Clec'h
  • Patent number: 10872752
    Abstract: A method and system for injecting an unconcentrated sample into a receiving LC/MS/MS system that is configured to determine a concentration of GenX within the unconcentrated sample, wherein the LC/MS/MS includes ESI. The unconcentrated sample is subjected to the following ESI conditions: i) a probe gas temperature of approximately 120° C. to approximately 160° C.; ii) a sheath gas heater setting of approximately 150° C. to approximately 275° C.; and iii) a sheath gas flow of approximately 6 L/min to approximately 11 L/min. The concentration of GenX is determined within the unconcentrated sample, wherein the concentration of GenX within the unconcentrated sample has a minimum reporting level of approximately 0.010 ?g/L.
    Type: Grant
    Filed: January 21, 2020
    Date of Patent: December 22, 2020
    Assignee: SUFFOLK COUNTY WATER AUTHORITY
    Inventor: Amanda Comando
  • Patent number: 10861689
    Abstract: Methods, systems and devices that generate differential axial transport in a fluidic device having at least one fluidic sample separation flow channel and at least one ESI emitter in communication with the at least one sample separation flow channel. In response to the generated differential axial transport, the at least one target analyte contained in a sample reservoir in communication with the sample separation channel is selectively transported to the at least one ESI emitter while inhibiting transport of contaminant materials contained in the sample reservoir toward the at least one ESI emitter thereby preferentially directing analyte molecules out of the at least one ESI emitter. The methods, systems and devices are particularly suitable for use with a mass spectrometer.
    Type: Grant
    Filed: June 3, 2019
    Date of Patent: December 8, 2020
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: John Scott Mellors, John Michael Ramsey, Nicholas George Batz
  • Patent number: 10854437
    Abstract: The present invention relates to improving the ability of a hyphenated instrument to analyze a sample benefiting from having the first instrument's analysis of the same sample. A fast switching mechanism can be used as the interface between an ion mobility spectrometer (IMS) and a mass spectrometer (MS) such that the obtained IMS spectrum is converted into a timing diagram that controls the vacuum inlet's size dynamically during analysis of a neutral and/or charged chemical and/or biological species such that a smaller pumping system can be used.
    Type: Grant
    Filed: August 13, 2018
    Date of Patent: December 1, 2020
    Assignee: Excellims Corporation
    Inventors: Mark A Osgood, Ching Wu
  • Patent number: 10854440
    Abstract: A method of ionising a sample is provided, comprising providing a fluid sample, wherein the fluid sample contains an analyte, applying one or more pulses of acoustic energy to the fluid sample to cause a spray of the fluid sample to eject from the surface of the fluid sample, and applying an AC, RF or alternating voltage to the fluid sample using an electrode.
    Type: Grant
    Filed: January 17, 2020
    Date of Patent: December 1, 2020
    Assignee: Micromass UK Limited
    Inventors: Michael Raymond Morris, Steven Derek Pringle, Richard Ellson, Richard Stearns, Lars Majlof, Ian Sinclair
  • Patent number: 10850273
    Abstract: There is provided a master for micro flow path creation, a transfer copy, and a method for producing a master for micro flow path creation by which transfer copies having an area with high hydrophilicity can be easily mass-produced, the master for micro flow path creation including: a base material; a main concave-convex portion provided on a surface of the base material and extending in a planar direction of the base material; and a fine concave-convex portion provided on a surface of the main concave-convex portion and having a narrower pitch than the main concave-convex portion. The fine concave-convex portion has an arithmetic average roughness of 10 nm to 150 nm and has a specific surface area ratio of 1.1 to 3.0.
    Type: Grant
    Filed: October 26, 2015
    Date of Patent: December 1, 2020
    Assignee: DEXERIALS CORPORATION
    Inventors: Shinya Suzuki, Kazuya Hayashibe, Akihiro Shibata
  • Patent number: 10847354
    Abstract: The present disclosure relates generally to rapid authentication methods using surface desorption ionization and mass spectrometry detection. In particular, the disclosure relates to rapid methods of authentication of commercial or consumer products using portable, low cost ambient ionization and a single quadrupole mass spectrometer.
    Type: Grant
    Filed: April 14, 2017
    Date of Patent: November 24, 2020
    Assignee: Waters Technologies Corporation
    Inventors: Gareth E. Cleland, Kari L. Organtini
  • Patent number: 10845344
    Abstract: Respective peaks detected on chromatograms created based on data obtained by conducting GC-MS analysis on a target sample are identified based on information stored in a compound database (S1, S2). A retention time list indicating relationships between compounds and measured peak retention times is created based on results of identification of the peak. Then a plurality of compounds in which the measured retention times are identical to each other or are within an allowable range are extracted and are combined into one group (S3, S4). A determination is made whether overlapping identifications exist by determining whether a single group includes a plurality of compounds (S5, S6). Retention times, mass spectrums, and confirmation ion ratio reference values stored in the compound database are used for the respective groups in which overlapping identifications are likely to exist so that a most likely compound candidate is selected (S7).
    Type: Grant
    Filed: July 8, 2016
    Date of Patent: November 24, 2020
    Assignee: SHIMADZU CORPORATION
    Inventor: Yukihiko Kudo
  • Patent number: 10832897
    Abstract: A method of analyzing a sample, the method includes separating precursor ions from the sample into narrow mass range groups based on mass-to-charge ratio; fragmenting the ions from each group to create groups of fragment ions; and mass analyzing fragment ions from each group of fragment ions using a long transient time mass analyzer, wherein the separation and fragmentation are decoupled from the mass analyzing and the cycle time of the high transient mass analyzer is greater than about five times longer than the cycle time of a narrow mass range scan time, and wherein the separation and fragmentation has a high duty cycle and the mass analyzing has a high duty cycle.
    Type: Grant
    Filed: October 19, 2018
    Date of Patent: November 10, 2020
    Assignee: THERMO FINNIGAN LLC
    Inventor: Viatcheslav V. Kovtoun
  • Patent number: 10832899
    Abstract: A mass and/or ion mobility spectrometer 100 comprises a sample plate 102 that supports a target sample 104. The spectrometer 100 further comprises a laser source 110 that generates a series of laser pulses 112 and a control system 118 that moves a focal point of the laser source 110 substantially continuously across the sample plate 102 such that respective packets of ions are generated by respective laser pulses 112 impinging upon respective locations on the target sample 104. The control system 118 performs plural cycles of ion analysis that each produce a set of spectral data corresponding to one or more of the packets of ions. The spectrometer 100 can provide mass and/or ion mobility spectrometry having increased speed and efficiency.
    Type: Grant
    Filed: February 11, 2019
    Date of Patent: November 10, 2020
    Assignee: Micromass UK Limited
    Inventors: Paul Murray, Mark William Towers, Matthew Havard
  • Patent number: 10825676
    Abstract: A quadrupole mass analyzer according to the present invention optimizes a stability band formation mode of a quadrupole system, so as to facilitate passing of ions and blocking of excessive ions, thereby improving the mass resolution without reducing the ion transmission efficiency. The solution of the present invention avoids the superimposition of high-frequency AC signals needed in the ion two-direction resonance frequency control in the prior art, and can effectively reduce the risk of quadrupole working performance reduction caused by the non-linear distortion of an RF voltage caused by bandwidth limitation in a fast RF circuit. In addition, a scanning speed of an ion-controlled electric field required by the quadrupole mass spectrometry can also be controlled faster because of reduction of limit bandwidth of various needed AC excitation signals. It is advantageous to obtain high-speed quadrupole scanning mass spectrometry performance.
    Type: Grant
    Filed: July 16, 2019
    Date of Patent: November 3, 2020
    Assignee: SHIMADZU CORPORATION
    Inventors: Gongyu Jiang, Wenjian Sun
  • Patent number: 10825674
    Abstract: An apparatus for mass spectrometry includes a plate on which a semiconductor wafer including an organic matter is disposed. A hybrid provider provides a ZnO-graphene hybrid to a predetermined region on the semiconductor wafer. A mass analyzer detects the organic matter in the predetermined region using laser desorption/ionization mass spectrometry (LDI-MS).
    Type: Grant
    Filed: February 28, 2019
    Date of Patent: November 3, 2020
    Assignees: SAMSUNG ELECTRONICS CO., LTD., INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY
    Inventors: Kook Joo Kim, KiJu Um, Cheol Sang Yoon, KangTaek Lee
  • Patent number: 10811240
    Abstract: The invention relates to an apparatus and a method for analysing a chemical composition of aerosol particles. The apparatus comprises an extractive electrospray ionisation source for extracting components, in particular organic compounds, from the aerosol particles and for ionising the components to ions, and a mass analyser, in particular a time of flight mass analyser, for analysing the ions, the mass analyser fluidly coupled to the extractive electrospray ionisation source. The method includes the steps of extracting components, in particular organic compounds, from the aerosol particles with an extractive electrospray ionisation source and ionising the components with the extractive electrospray ionisation source to ions, transferring the ions to a mass analyser, in particular a time of flight mass analyser, the mass analyser being fluidly coupled to the extractive electrospray ionisation source, and analysing the ions with the mass analyser.
    Type: Grant
    Filed: September 7, 2017
    Date of Patent: October 20, 2020
    Assignee: TOFWERK AG
    Inventors: Felipe Lopez-Hilfiker, Marc Gonin, Mike Cubison
  • Patent number: 10811242
    Abstract: Methods and systems are provided for ionizing molecules for the purpose of analysis by mass spectrometry, in which gaseous material from a sample substrate is generated using laser desorption. The laser is provided having a pulse range of about 1-1000 picoseconds to produce the gaseous material. The gaseous material is heated to generate ions from the molecules present in the gaseous material where the amount of heat that is applied is in the temperature range of 45° C. to 250° C. and the applied heat results in soft ionization of the molecules. The ionized molecules are transported to a mass spectrometer for analysis.
    Type: Grant
    Filed: June 9, 2017
    Date of Patent: October 20, 2020
    Assignee: University Health Network
    Inventors: Arash Zarrine-Afsar, Howard Joeseph Ginsberg, Michael Woolman
  • Patent number: 10799165
    Abstract: The invention generally relates to enclosed desorption electrospray ionization probes, systems, and methods. In certain embodiments, the invention provides a source of DESI-active spray, in which a distal portion of the source is enclosed within a transfer member such that the DESI-active spray is produced within the transfer member.
    Type: Grant
    Filed: December 19, 2019
    Date of Patent: October 13, 2020
    Assignee: Purdue Research Foundation
    Inventors: Robert Graham Cooks, Zheng Ouyang, Chien-hsun Chen, Ziqing Lin, Livia Schiavinato Eberlin
  • Patent number: 10796878
    Abstract: Provided are elements for an ion implanter and an ion generating device including the same. The elements include a repeller, a cathode, a chamber wall, and a slit member constituting an arc chamber of an ion generating device for ion implantation used in the fabrication of a semiconductor device. A coating structure including a semicarbide layer is provided to each of the elements in order to stabilize the element against thermal deformation, protect the element from wear, and prevent a deposition product from being peeled off. The coating structure enables precise ion implantation without a change in the position of ion generation or distortion of the equipment. The coating structure allows electrons to be uniformly reflected into the arc chamber to increase the uniformity of plasma, resulting in an improvement in the dissociation efficiency of an ion source gas. The coating structure significantly improves the service life of the element compared to those of existing elements.
    Type: Grant
    Filed: September 25, 2019
    Date of Patent: October 6, 2020
    Assignee: VALUE ENGINEERING, LTD.
    Inventor: Kyou Tae Hwang
  • Patent number: 10796895
    Abstract: Devices, systems and methods including a spray chamber are described. In certain examples, the spray chamber may be configured with an outer chamber configured to provide tangential gas flows. In other instances, an inner tube can be positioned within the outer chamber and may comprise a plurality of microchannels. In some examples, the outer chamber may comprise dual gas inlet ports. In some instances, the spray chamber may be configured to provide tangential gas flow and laminar gas flows to prevent droplet formation on surfaces of the spray chamber. Optical emission devices, optical absorption devices and mass spectrometers using the spray chamber are also described.
    Type: Grant
    Filed: August 26, 2019
    Date of Patent: October 6, 2020
    Assignee: PerkinElmer Health Sciences Canada, Inc.
    Inventors: Chady Stephan, Hamid Badiei, Serguei Savtchenko, Samad Bazargan
  • Patent number: 10792661
    Abstract: A device includes a first structure with a sheet layer with a plurality of discrete through-holes and a second structure coupled to the first structure. At least a portion of a first surface of the sheet layer of the first structure is exposed from the second structure. A top portion of the sheet layer, including the exposed portion of the first surface of the sheet layer, includes fluorocarbon. The second structure includes a material of a higher surface tension than the top of the sheet layer. A second surface of the sheet layer, opposite to the first surface of the sheet layer, is embedded in the second structure. The second structure extends at least partially into the plurality of discrete through-holes of the first structure.
    Type: Grant
    Filed: April 11, 2018
    Date of Patent: October 6, 2020
    Assignee: CURIOX BIOSYSTEMS PTE LTD.
    Inventors: Eng Seng Lim, Siah Chong Cheong, Namyong Kim
  • Patent number: 10796892
    Abstract: A sample mounting plate which is used for mass spectrometry according to MALDI process and which is provided with at least one sample loading spot for mounting a sample on a substrate, wherein: a hydrophilic surface produced by a first hydrophilic film is formed within the sample loading spot on a surface of the substrate provided with the sample loading spot; a hydrophobic surface produced by a hydrophobic film is formed on the outside of the hydrophilic surface; and a boundary part, in which a hydrophilic member or a second hydrophilic film having a higher hydrophilicity than the first hydrophilic film is exposed, is formed at the boundary between the hydrophilic surface and the hydrophobic surface.
    Type: Grant
    Filed: September 17, 2018
    Date of Patent: October 6, 2020
    Assignees: CITIZEN FINEDEVICE CO., LTD., CITIZEN WATCH CO., LTD.
    Inventors: Kazuhiro Toriumi, Tomoki Kuratomi
  • Patent number: 10796896
    Abstract: The invention relates to time-of-flight mass spectrometers with pulsed ionization of samples, for example by matrix-assisted laser desorption (MALDI), where the samples are located on a sample support and are irradiated and ionized one after the other in a grid by a position-controlled desorption beam. An ion-optical puller lens arrangement is positioned in front of the sample support, with at least one of the lens diaphragms in the arrangement being subdivided into segments, and a voltage supply being able to supply the segments, or some of them, with different voltages, depending on the impact position of the desorption beam on the support plate. It is then possible to virtually shift the effective ion-optical focusing center of the lens away from the axis, and to focus an ion beam, which is generated off the real lens axis, into a beam which runs essentially parallel to the real lens axis, with no time phase shift for ions of the same mass.
    Type: Grant
    Filed: May 24, 2019
    Date of Patent: October 6, 2020
    Inventor: Sebastian Böhm
  • Patent number: 10777400
    Abstract: The invention generally relates to apparatuses for focusing ions at or above ambient pressure and methods of use thereof. In certain embodiments, the invention provides an apparatus for focusing ions that includes an electrode having a cavity, at least one inlet within the electrode configured to operatively couple with an ionization source, such that discharge generated by the ionization source is injected into the cavity of the electrode, and an outlet. The cavity in the electrode is shaped such that upon application of voltage to the electrode, ions within the cavity are focused and directed to the outlet, which is positioned such that a proximal end of the outlet receives the focused ions and a distal end of the outlet is open to ambient pressure.
    Type: Grant
    Filed: February 27, 2020
    Date of Patent: September 15, 2020
    Assignee: Purdue Research Foundation
    Inventors: Robert Graham Cooks, Zane Baird, Wen-Ping Peng
  • Patent number: 10763095
    Abstract: In the mass spectrometer system, a tip portion of a cylindrical portion (891) of a capillary (89) is coated with a coating material (892), the tip portion being an injection part for injecting a sample solution to an ionization section. Therefore, it is possible to suppress, by the coating material (892), the deformation of the capillary (89) when the sample solution is injected. In addition, it is possible to suppress the corrosion and the deformation of the capillary (89) by the coating material (892). As a result, the stability of the analysis operation in mass spectrometer system (1) can be improved.
    Type: Grant
    Filed: June 2, 2016
    Date of Patent: September 1, 2020
    Assignee: SHIMADZU CORPORATION
    Inventors: Manabu Ueda, Wataru Fukui
  • Patent number: 10755913
    Abstract: A package-level, integrated high-vacuum ion-chip enclosure having improved thermal characteristics is disclosed. Enclosures in accordance with the present invention include first and second chambers that are located on opposite sides of a chip carrier, where the chambers are fluidically coupled via a conduit through the chip carrier. The ion trap is located in the first chamber and disposed on the chip carrier. A source for generating an atomic flux is located in the second chamber. The separation of the source and ion trap in different chambers affords thermal isolation between them, while the conduit between the chambers enables the ion trap to receive the atomic flux.
    Type: Grant
    Filed: March 26, 2018
    Date of Patent: August 25, 2020
    Assignee: Duke University
    Inventors: Jungsang Kim, Kai Hudek, Geert Vrijsen, Robert Spivey, Peter Maunz
  • Patent number: 10755915
    Abstract: Mass spectrometry systems or assemblies therefore include an ionizer that includes at least one planar conductor, a mass analyzer with a planar electrode assembly, and a detector comprising at least one planar conductor. The ionizer, the mass analyzer and the detector are attached together in a compact stack assembly. The stack assembly has a perimeter that bounds an area that is between about 0.01 mm2 to about 25 cm2 and the stack assembly has a thickness that is between about 0.1 mm to about 25 mm.
    Type: Grant
    Filed: May 6, 2019
    Date of Patent: August 25, 2020
    Assignee: The University of North Carolina at Chapel Hill
    Inventor: John Michael Ramsey
  • Patent number: 10748751
    Abstract: In a simultaneous multicomponent analysis for a number of target compounds, an MRM transition which does not give the highest signal intensity but gives a lower signal intensity is selected for a compound having a high measurement sensitivity or a compound having a high measurement target concentration. If the signal intensity is still high, the level of collision energy (CE) is changed from an optimum level. The MRM transition, CE level and other measurement conditions determined for each compound in this manner are stored in a compound-related information storage 41. In the process of preparing a control sequence for the simultaneous multicomponent analysis, the measurement conditions stored in the storage section 41 are used. The use of those conditions prevents the saturation of the signal for a high-concentration compound while ensuring a sufficiently high level of sensitivity for a low-concentration compound.
    Type: Grant
    Filed: March 12, 2020
    Date of Patent: August 18, 2020
    Assignee: SHIMADZU CORPORATION
    Inventor: Riki Kitano
  • Patent number: 10734216
    Abstract: A pneumatic method, and associated apparatus, for injecting a discrete sample plug into the separation channel of an electrophoresis microchip (100) is disclosed. In a first step, pressurized gas (90) is applied to the sample (30) and background electrolyte (20) reservoirs such that the pressure is higher there than at the sample waste reservoir (35) to create a focused sample stream at the junction between the sample and separation channels. In a second step, the pressure at the sample reservoir (30) is reduced in order to pneumatically inject the sample plug into the separation channel. The waste reservoir (35) may be connected to a pressure reducing device (91). The methods, systems and devices are particularly suitable for use with a mass spectrometer (200i).
    Type: Grant
    Filed: May 10, 2016
    Date of Patent: August 4, 2020
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: John Scott Mellors, Erin Anne Redman, John Michael Ramsey
  • Patent number: 10734214
    Abstract: An ion source adapter configured to enable a mass spectrometer, used with a voltage applied to a nebulizer side of an ion source configured to generate an ion, to be used with the nebulizer side grounded, the ion source adapter comprising a tube inserted between an ion introduction port of a capillary of the mass spectrometer and the nebulizer, the tube being formed of an insulator and allowing ions to pass through an interior thereof; a fixing tool configured to align and fix a mass spectrometer side of the tube and the ion introduction port of the capillary; and an electrode configured to apply a voltage to a nebulizer side of the tube, wherein outer peripheries of the nebulizer side and/or the mass spectrometer side of the tube are coated with a conductor, and are used for electric conduction.
    Type: Grant
    Filed: March 24, 2017
    Date of Patent: August 4, 2020
    Assignee: HUMAN METABOLOME TECHNOLOGIES, INC.
    Inventors: Hitoshi Sagawa, Kazunori Sasaki
  • Patent number: 10725006
    Abstract: Methods and apparatus for monitoring air samples for the presence of the explosive TATP are disclosed. A preferred approach employs proton transfer reaction mass spectrometry PTR-MS). The system may be operated continuously on a real time or near real time basis. A delivery tube of specific dimensions and materials is employed to introduce the sample into the ionization chamber which in turn generates the ions which are delivered to the mass spectrometer for determining the m/z values. The system may employ a plurality of ionization chambers to reduce the amount of false negative identifiers. A multiple inlet ion funnel may be employed to combine the ions from each of the ionization chambers. Chemical ionization may be employed. A validation module may be employed to reduce the amount of false positive identifiers.
    Type: Grant
    Filed: February 26, 2018
    Date of Patent: July 28, 2020
    Assignee: RJ LEE GROUP, INC.
    Inventors: Heinz J. Huber, Richard J. Lee
  • Patent number: 10727037
    Abstract: A mass spectrometer for performing a selected ion monitoring (SIM) measurement and/or multiple reaction monitoring (MRM) measurement on each of one or a plurality of target components contained in a sample under one or a plurality of measurement conditions is provided. The mass spectrometer includes: a storage section 41 in which SIM measurement conditions and/or MRM measurement conditions are previously stored for a plurality of components; a measurement condition selection receiver 43 for performing the following operations when a command to create a method file in which measurement conditions are described is issued by a user: reading the selected ion monitoring measurement conditions and/or multiple reaction monitoring measurement conditions of the plurality of components, displaying the measurement conditions on a screen, and receiving a selection by the user; and a method file creator 48 for creating a method file in which a measurement condition selected by the user is described.
    Type: Grant
    Filed: February 22, 2018
    Date of Patent: July 28, 2020
    Assignee: SHIMADZU CORPORATION
    Inventor: Yuka Fujito
  • Patent number: 10720316
    Abstract: The invention generally relates to sample analysis systems and methods of use thereof. In certain aspects, the invention provides a system for analyzing a sample that includes an ion generator configured to generate ions from a sample. The system additionally includes an ion separator configured to separate at or above atmospheric pressure the ions received from the ion generator without use of laminar flowing gas, and a detector that receives and detects the separated ions.
    Type: Grant
    Filed: August 14, 2018
    Date of Patent: July 21, 2020
    Assignee: Purdue Research Foundation
    Inventors: Robert Graham Cooks, Zane Baird, Pu Wei