Laterally Resonant Ion Path Patents (Class 250/292)
  • Patent number: 10978288
    Abstract: A miniature mass spectrometer is disclosed comprising an atmospheric pressure ionisation source 701, a first vacuum chamber having an atmospheric pressure sampling orifice or capillary, a second vacuum chamber located downstream of the first vacuum chamber and a third vacuum chamber located downstream of the second vacuum chamber. A first vacuum pump 707 is arranged and adapted to pump the first vacuum chamber, wherein the first vacuum pump is arranged and adapted to maintain the first vacuum chamber at a pressure <10 mbar. A first RF ion guide 702 is located within the first vacuum chamber and an ion detector 705 is located in the third vacuum chamber. The ion path length from the atmospheric pressure sampling orifice or capillary to an ion detecting surface of the ion detector 705 is ?400 mm.
    Type: Grant
    Filed: August 15, 2019
    Date of Patent: April 13, 2021
    Assignee: Micromass UK Limited
    Inventors: David Gordon, Daniel James Kenny
  • Patent number: 10957525
    Abstract: A method of mass and/or ion mobility spectrometry is disclosed that comprises accumulating ions for a first period of time (T1) one or more times so as to form one or more first groups of ions, accumulating ions for a second period of time (T2) one or more times so as to form one or more second groups of ions, wherein the second period of time (T2) is less that the first period of time (T1), analysing the one or more first groups of ions to generate one or more first data sets, analysing the one or more second groups of ions to generate one or more second data sets, and determining whether the one or more first data sets comprise saturated and/or distorted data. If it is determined that the one or more first data sets comprise saturated and/or distorted data, then the method further comprises replacing the saturated and/or distorted data from the one or more first data sets with corresponding data from the one or more second data sets.
    Type: Grant
    Filed: December 24, 2019
    Date of Patent: March 23, 2021
    Assignee: Micromass UK Limited
    Inventors: Martin Raymond Green, Jason Lee Wildgoose, Steven Derek Pringle, Kevin R. Howes
  • Patent number: 10937640
    Abstract: A miniature electrode apparatus is disclosed for trapping charged particles, the apparatus includes, along a longitudinal direction, a first end cap electrode, a central electrode having an aperture, and a second end cap electrode. The aperture is elongated in the lateral plane and extends through the central electrode along the longitudinal direction and the central electrode surrounds the aperture in a lateral plane perpendicular to the longitudinal direction to define a transverse cavity for trapping charged particles. Electric fields can be applied in a y-direction of the lateral plane across one or more planes perpendicular to the longitudinal axis to translocate and/or manipulate ion trajectories.
    Type: Grant
    Filed: March 25, 2019
    Date of Patent: March 2, 2021
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: John Michael Ramsey, Andrew Hampton, Kevin Schultze
  • Patent number: 10930487
    Abstract: Certain configurations of devices are described herein that include a DC multipole that is effective to doubly bend the ions in an entering particle beam. In some instances, the devices include a first multipole configured to provide a DC electric field effective to direct first ions of an entering particle beam along a first internal trajectory at an angle different from the entry trajectory of the particle beam. The first multipole may also be configured to direct the ions in the first multipole along a second internal trajectory that is different than the angle of the first internal trajectory of the particle beam.
    Type: Grant
    Filed: August 9, 2019
    Date of Patent: February 23, 2021
    Assignee: PerkinElmer Health Sciences Canada, Inc.
    Inventors: Hamid Badiei, Samad Bazargan
  • Patent number: 10840077
    Abstract: An ion transfer device that receives ions from an ion inlet and delivers the ions to an ion outlet of the ion transfer device, the ion transfer device including: a plurality of electrodes disposed at least in part inside an enclosure such that one or more electrodes of the plurality of electrodes are configured to be flexible or flexibly connected to each other, and such that the ion transfer device is configured to be flexible and is configured to form one or more curvatures while transferring the ions.
    Type: Grant
    Filed: July 12, 2018
    Date of Patent: November 17, 2020
    Assignee: Trace Matters Scientific LLC
    Inventor: Mazdak Taghioskoui
  • Patent number: 10832900
    Abstract: A mass filter is disclosed having at least one electrode (42-48) comprising an aperture (43) or recess. Voltages are applied to the electrodes (42-48) of the mass filter such that ions having mass to charge ratios in a desired range are confined by the electrodes and are transmitted along and through the mass filter, whereas ions (47,49) having mass to charge ratios outside of said desired range are unstable and pass into the aperture (43) or recess such that they are filtered out by the mass filter. The aperture (43) or recess reduces or eliminates the number of ions that would otherwise impact the electrode surface facing the ion transmission axis and hence reduces degradation of the ion transmission properties of the mass filter.
    Type: Grant
    Filed: September 6, 2019
    Date of Patent: November 10, 2020
    Assignee: Micromass UK Limited
    Inventors: Martin Green, Jason Wildgoose, Keith Richardson, Kevin Giles, Daniel Kenny, David Langridge, Richard Moulds
  • Patent number: 10811243
    Abstract: Disclosed herein is an ion supply system, having an ion source emitting ions into a fore vacuum chamber, an ion transport device having stacked electrodes arranged in the fore vacuum chamber, a control system supplying an oscillatory voltage to the electrodes of the ion transport device and a vacuum chamber, arranged downstream from the ion transport device. A vacuum gauge is arranged in the vacuum chamber. The pressure signal of the vacuum gauge is supplied to the control system supplying the oscillatory voltage to electrodes of the ion transport device. The control system adjusts the amplitude of the oscillatory voltage in accordance with the pressure signal.
    Type: Grant
    Filed: December 19, 2018
    Date of Patent: October 20, 2020
    Assignee: Thermo Fisher Scientific (Bremen) GMBH
    Inventors: Amelia Corinne Peterson, Denis Chernyshev, Jan-Peter Hauschild, Erik Couzijn
  • Patent number: 10804089
    Abstract: A switch for coupling a first ion manipulation device to a second ion manipulation device comprises a first surface and a second surface, at least one first electrode coupled to each of the first and second surface and configured to receive a first voltage and generate a first potential, and at least one second electrode coupled to each of the first and second surface and configured to receive a second voltage and generate a second potential, wherein the first potential inhibits the motion of ions along a first direction and the second potential inhibits the motion of ions along a second direction different from the first direction.
    Type: Grant
    Filed: July 11, 2018
    Date of Patent: October 13, 2020
    Assignee: Batelle Memorial Institute
    Inventors: Yehia M. Ibrahim, Richard D. Smith
  • Patent number: 10796893
    Abstract: RF ion guides are configured as an array of elongate electrodes arranged symmetrically about a central axis, to which RF voltages are applied. The RF electrodes include at least a portion of their length that is semi-transparent to electric fields. Auxiliary electrodes are then provided proximal to the RF electrodes distal to the ion guide axis, such that application of DC voltages to the auxiliary electrodes causes an auxiliary electric field to form between the auxiliary electrodes and the ion guide RF electrodes. A portion of this auxiliary electric field penetrates through the semi-transparent portions of the RF electrodes, such that the potentials within the ion guide are modified. The auxiliary electrode structures and voltages can be configured so that a potential gradient develops along the ion guide axis due to this field penetration, which provides an axial motive force for collision damped ions.
    Type: Grant
    Filed: October 3, 2019
    Date of Patent: October 6, 2020
    Assignee: PerkinElmer Health Sciences, Inc.
    Inventor: David G. Welkie
  • Patent number: 10770279
    Abstract: An ion transfer apparatus for transferring ions from an ion source at an ion source pressure, which ion source pressure is greater than 500 mbar, along a path towards a mass analyser at a mass analyser pressure that is lower than the ion source pressure. The apparatus includes a plurality of pressure controlled chambers, wherein each pressure controlled chamber in the ion transfer apparatus includes an ion inlet opening for receiving ions from the ion source on the path and an ion outlet opening for outputting the ions on the path. The plurality of pressure controlled chambers are arranged in succession along the path from an initial pressure controlled chamber to a final pressure controlled chamber, wherein an ion outlet opening of each pressure controlled chamber other than the final pressure controlled chamber is in flow communication with the ion inlet opening of a successive adjacent pressure controlled chamber.
    Type: Grant
    Filed: October 20, 2016
    Date of Patent: September 8, 2020
    Assignee: SHIMADZU CORPORATION
    Inventors: Roger Giles, Alina Giles
  • Patent number: 10724990
    Abstract: A mass spectrometer is disclosed comprising an ion mobility spectrometer or separator and an ion guide arranged downstream of the ion mobility spectrometer or separator. A plurality of axial potential wells are created in the ion guide so that ions received from the ion mobility spectrometer or separator become confined in separate axial potential wells. The potential wells maintain the fidelity and/or composition of ions received from the ion mobility spectrometer or separator. The potential wells are translated along the length of the ion guide.
    Type: Grant
    Filed: August 8, 2016
    Date of Patent: July 28, 2020
    Assignee: MICROMASS UK LIMITED
    Inventors: Robert Harold Bateman, Kevin Giles, Steven Derek Pringle, Jason Lee Wildgoose
  • Patent number: 10727038
    Abstract: Certain configurations of devices are described herein that include DC multipoles that are effective to direct ions. In some instances, the devices include a first multipole configured to provide a DC electric field effective to direct first ions of an entering particle beam along a first exit trajectory that is substantially orthogonal to an entry trajectory of the particle beam. The devices may also include a second multipole configured to provide a DC electric field effective to direct the received first ions from the first multipole along a second exit trajectory that is substantially orthogonal to the first exit trajectory.
    Type: Grant
    Filed: January 20, 2019
    Date of Patent: July 28, 2020
    Assignee: PerkinElmer Health Sciences Canada, Inc.
    Inventors: Kaveh Kahen, Hamid Badiei
  • Patent number: 10707066
    Abstract: Four main rod electrodes included in a main electrode section are disposed in a rotationally symmetric manner around an ion optical axis. Among four pre-rod electrodes included in a pre-electrode section disposed in front of the main electrode section, two are in contact with a circle of a radius r0, whereas the other two are disposed to be in contact with a circle of a radius R0 larger than r0, resulting in rotational asymmetry around the ion optical axis. Accordingly, a shape of acceptance on an x-y plane regarding positions of ions in the pre-electrode section becomes elliptical. This allows the shape of the acceptance to become gradually flat as the ions travel along the ion optical axis, reducing a mismatch between emittance of incoming ions and the acceptance on a receiving side, and relieving ion loss during ion introduction.
    Type: Grant
    Filed: December 2, 2015
    Date of Patent: July 7, 2020
    Assignee: SHIMADZU CORPORATION
    Inventors: Shinji Miyauchi, Hiroko Ueda, Yoshihiro Ueno
  • Patent number: 10622202
    Abstract: The invention generally relates to ion traps that operate by applying an inverse Mathieu q scan. In certain embodiments, the invention provides systems that include a mass spectrometer having an ion trap and a central processing unit (CPU). The CPU includes storage coupled to the CPU for storing instructions that when executed by the CPU cause the system to apply an inverse Mathieu q scan to the ion trap.
    Type: Grant
    Filed: October 20, 2017
    Date of Patent: April 14, 2020
    Assignee: Purdue Research Foundation
    Inventors: Robert Graham Cooks, Dalton Snyder
  • Patent number: 10615018
    Abstract: Certain embodiments described herein are directed to collision cells that comprise one or more integrated lenses. In some examples, a lens is coupled to two sections of a sectioned quadrature rod assembly, the lens comprising an aperture and a plurality of separate conductive elements disposed each one side of the lens, in which a respective disposed conductive element on one side of the lens is configured to electrically couple to a first, second, third, and fourth pole segments of the sectioned quadrature rod assembly.
    Type: Grant
    Filed: September 28, 2018
    Date of Patent: April 7, 2020
    Assignee: PerkinElmer Health Sciences, Inc.
    Inventor: Urs Steiner
  • Patent number: 10566169
    Abstract: A charged particle buncher includes a series of spaced apart electrodes arranged to generate a shaped electric field. The series includes a first electrode, a last electrode and one or more intermediate electrodes. The charged particle buncher includes a waveform device attached to the electrodes and configured to apply a periodic potential waveform to each electrode independently in a manner so as to form a quasi-electrostatic time varying potential gradient between adjacent electrodes and to cause spatial distribution of charged particles that form a plurality of nodes and antinodes. The nodes have a charged particle density and the antinodes have substantially no charged particle density, and the nodes and the antinodes are formed from a charged particle beam with an energy less than or equal to 500 keV.
    Type: Grant
    Filed: June 30, 2009
    Date of Patent: February 18, 2020
    Assignee: NexGen Semi Holding, Inc.
    Inventors: Mark Joseph Bennahmias, Michael John Zani, Jeffrey Winfield Scott
  • Patent number: 10559455
    Abstract: The invention generally relates to mass spectrometry probes and systems for ionizing a sample. In certain embodiments, the invention provides a mass spectrometry probe including a substrate in which a portion of the substrate is coated with a material, a portion of which protrudes from the substrate.
    Type: Grant
    Filed: July 19, 2019
    Date of Patent: February 11, 2020
    Assignee: Purdue Research Foundation
    Inventors: Robert Graham Cooks, Depanjan Sarkar, Thalappil Pradeep, Rahul Narayanan
  • Patent number: 10553415
    Abstract: An ion manipulation device is disclosed comprising: an ion receiving region (30) for receiving ions; a pair of electrodes (14,16) adjacent the ion receiving region (30); and an AC or RF voltage supply (18) arranged to apply an AC or RF voltage to said electrodes (14,16), or arranged and configured to generate an electromagnetic field that couples to said electrodes (14,16) in use, such that an electromagnetic standing wave (24) is generated between said electrodes (14,16). A first of the electrodes (14) comprises one or more apertures through which an electric field from the standing wave (24) penetrates and enters the ion receiving region (30), in use, for urging said ions away from the one or more apertures.
    Type: Grant
    Filed: July 5, 2017
    Date of Patent: February 4, 2020
    Assignee: Micromass UK Limited
    Inventor: John Brian Hoyes
  • Patent number: 10504712
    Abstract: A mass spectrometry device comprises a reaction gas introduction device and a gas phase molecule-ion reaction mass spectrometry analysis device, wherein the reaction gas introduction device is connected to the gas phase molecule-ion reaction mass spectrometry analysis device; the reaction gas introduction device is configured to introduce reaction gas into the gas phase molecule-ion reaction mass spectrometry analysis device; and the gas phase molecule-ion reaction mass spectrometry analysis device is configured to enable molecules or ions to be subjected to a reaction and carry out mass spectrometry analysis on a reaction result. The reaction gas introduction device comprises a reaction gas container, the reaction gas container being configured to contain gas or volatile liquid or solid and generate gas molecules needed by a reaction; and a reaction gas quantitation device, configured to carry out flow control on the gas molecules.
    Type: Grant
    Filed: March 23, 2016
    Date of Patent: December 10, 2019
    Assignee: National Institute of Metrology, China
    Inventors: You Jiang, Xiang Fang, Xing-Chuang Xiong, Ze-Jian Huang
  • Patent number: 10497551
    Abstract: An ion storage device is provided which is arranged and adapted: (i) to receive first ions which have been temporally separated according to a first physico-chemical property during a first cycle of operation; (ii) to store the first ions in a first plurality of separate sections of the ion storage device so that first ions having different first physico-chemical properties are stored in different sections of the ion storage device; (iii) to receive second ions which have been temporally separated according to the first physico-chemical property during a second subsequent cycle of operation; and (iv) to store the second ions in the ion storage device so that the first and second ions are simultaneously stored within the ion storage device and so that at least some of the first and second ions having substantially the same first physico-chemical property are stored in the same section of the ion storage device.
    Type: Grant
    Filed: December 18, 2014
    Date of Patent: December 3, 2019
    Assignee: Micromass UK Limited
    Inventor: Jason Lee Wildgoose
  • Patent number: 10453667
    Abstract: A mass filter is disclosed having at least one electrode (42-48) comprising an aperture (43) or recess. Voltages are applied to the electrodes (42-48) of the mass filter such that ions having mass to charge ratios in a desired range are confined by the electrodes and are transmitted along and through the mass filter, whereas ions (47,49) having mass to charge ratios outside of said desired range are unstable and pass into the aperture (43) or recess such that they are filtered out by the mass filter. The aperture (43) or recess reduces or eliminates the number of ions that would otherwise impact the electrode surface facing the ion transmission axis and hence reduces degradation of the ion transmission properties of the mass filter.
    Type: Grant
    Filed: May 31, 2016
    Date of Patent: October 22, 2019
    Assignee: Micromass UK Limited
    Inventors: Martin Green, Jason Wildgoose, Keith Richardson, Kevin Giles, Daniel Kenny, David Langridge, Richard Moulds
  • Patent number: 10453666
    Abstract: RF ion guides are configured as an array of elongate electrodes arranged symmetrically about a central axis, to which RF voltages are applied. The RF electrodes include at least a portion of their length that is semi-transparent to electric fields. Auxiliary electrodes are then provided proximal to the RF electrodes distal to the ion guide axis, such that application of DC voltages to the auxiliary electrodes causes an auxiliary electric field to form between the auxiliary electrodes and the ion guide RF electrodes. A portion of this auxiliary electric field penetrates through the semi-transparent portions of the RF electrodes, such that the potentials within the ion guide are modified. The auxiliary electrode structures and voltages can be configured so that a potential gradient develops along the ion guide axis due to this field penetration, which provides an axial motive force for collision damped ions.
    Type: Grant
    Filed: July 23, 2018
    Date of Patent: October 22, 2019
    Assignee: PerkinElmer Health Sciences, Inc.
    Inventor: David G. Welkie
  • Patent number: 10444185
    Abstract: A reference value selection unit selects a reference value that lies in a predetermined margin from reference sample data corresponding to a set reference sample. A data acquisition unit acquires mass spectrum data in a data acquisition range including a set analysis range and the margin. A data correction unit corrects the mass spectrum data based on the reference value and a measured value on the reference sample in the data acquisition range. When no reference value lies in the margin, the reference value selection unit selects a reference value that lies outside the analysis range but closest to the margin. The data acquisition unit acquires mass spectrum data in a data acquisition range expanded to allow the reference value to lie in the data acquisition range. The data correction unit corrects the mass spectrum data based on the reference value and the measured value in the data acquisition range.
    Type: Grant
    Filed: April 11, 2016
    Date of Patent: October 15, 2019
    Assignee: SHIMADZU CORPORATION
    Inventors: Atsushige Ikeda, Tohru Shiohama
  • Patent number: 10446381
    Abstract: A method of introducing and ejecting ions from an ion entry/exit device (4) is disclosed. The ion entry/exit device (4) has at least two arrays of electrodes (20,22). The device is operated in a first mode wherein DC potentials are successively applied to successive electrodes of at least one of the electrode arrays ((20,22) in a first direction such that a potential barrier moves along the at least one array in the first direction and drives ions into and/or out of the device in the first direction. The device is also operated in a second mode, wherein DC potentials are successively applied to successive electrodes of at least one of the electrode arrays (20,22) in a second, different direction such that a potential barrier moves along the array in the second direction and drives ions into and/or out of the device in the second direction. The device provides a single, relatively simple device for manipulating ions in multiple directions.
    Type: Grant
    Filed: May 15, 2018
    Date of Patent: October 15, 2019
    Assignee: Micromass UK Limited
    Inventors: Kevin Giles, David J. Langridge, Jason Lee Wildgoose
  • Patent number: 10438787
    Abstract: The disclosure features mass spectrometry systems that include: an ion source; a module featuring an ion trap, an ion detector, and a module housing that at least partially surrounds the ion trap and the ion detector; and a vacuum pump featuring a housing having a recess dimensioned to receive the module, so that when the module is positioned within the recess of the vacuum pump housing, a portion of the module is surrounded by the vacuum pump housing, and during operation of the system, the ion source, ion trap, ion detector, and vacuum pump are connected along a common gas flow path and heat is transferred from the vacuum pump to the module.
    Type: Grant
    Filed: June 30, 2017
    Date of Patent: October 8, 2019
    Assignee: 908 Devices Inc.
    Inventors: Tony Liepert, Kevin McCallion, Christopher D. Brown, Kevin J. Knopp, Michael Jobin
  • Patent number: 10431442
    Abstract: A method of mass spectral analysis in an analytical electrostatic trap (14) is disclosed. The electrostatic trap (14) defines an electrostatic field volume and includes trap electrodes having static and non-ramped potentials. The method comprises injecting a continuous ion beam into the electrostatic field volume.
    Type: Grant
    Filed: August 7, 2017
    Date of Patent: October 1, 2019
    Assignee: LECO Corporation
    Inventor: Anatoly N. Verenchikov
  • Patent number: 10424472
    Abstract: A first rod electrode set has a first center axis, into which ions and air current are introduced. A second rod electrode set has a second center axis at a distance from the first center axis, from which the ions are discharged. A power supply applies voltages to the first rod electrode set and the second rod electrode set. The first rod electrode set and the second rod electrode set have a region where the sets overlap each other in the longitudinal direction, and form a single multipole ion guide by being combined to each other in the region. Different offset DC voltages are applied to the first rod electrode set and the second rod electrode set, respectively, and a DC potential for moving the ions to the second rod electrode set in the region is formed, the ions having been guided by the first rod electrode set.
    Type: Grant
    Filed: December 21, 2018
    Date of Patent: September 24, 2019
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Masuyuki Sugiyama, Hideki Hasegawa, Masao Suga, Hiroyuki Satake, Yuichiro Hashimoto
  • Patent number: 10424475
    Abstract: A method of operating an electrostatic trapping mass analyzer, comprising: introducing a sample of ions into a trapping region of the mass analyzer, wherein a trapping field within the trapping region is such that the ions exhibit radial motion with respect to a central longitudinal axis of the trapping region while undergoing harmonic motion in a dimension defined by the central longitudinal axis, the frequency of harmonic motion of a particular ion being a function of its mass-to-charge ratio; superimposing a modulation field onto the trapping field within the trapping region, the modulation field acting to either increase or reduce the harmonic motion energies of the ions by an amount varying according to the frequency of harmonic motion; and acquiring a mass spectrum of the ions in the trapping region by measuring a signal representative of an image current induced by the harmonic motion of the ions.
    Type: Grant
    Filed: December 17, 2018
    Date of Patent: September 24, 2019
    Assignee: THERMO FINNIGAN LLC
    Inventors: Chad R. Weisbrod, Michael W. Senko, Jesse D. Canterbury, John E. P. Syka
  • Patent number: 10395914
    Abstract: An ion trapping system is disclosed comprising an ion urging system for urging ions to spread out within an ion trapping region. Alternatively, the ion trapping system may deflect ions such that ions enter the ion trapping region at different locations. Alternatively, an ion deflector may be arranged upstream of, or at the entrance to, the ion trapping region, for deflecting ions such that ions enter the ion trapping region with different speeds so that the ions spread out within the ion trapping region.
    Type: Grant
    Filed: May 24, 2017
    Date of Patent: August 27, 2019
    Assignee: MICROMASS UK LIMITED
    Inventors: Martin Raymond Green, Kevin Giles, David J. Langridge
  • Patent number: 10381210
    Abstract: Certain configurations of devices are described herein that include a DC multipole that is effective to doubly bend the ions in an entering particle beam. In some instances, the devices include a first multipole configured to provide a DC electric field effective to direct first ions of an entering particle beam along a first internal trajectory at an angle different from the entry trajectory of the particle beam. The first multipole may also be configured to direct the ions in the first multipole along a second internal trajectory that is different than the angle of the first internal trajectory of the particle beam.
    Type: Grant
    Filed: May 25, 2016
    Date of Patent: August 13, 2019
    Assignee: PerkinElmer Health Sciences Canada, Inc.
    Inventors: Hamid Badiei, Samad Bazargan
  • Patent number: 10381213
    Abstract: A linear ion trap includes a quadrupole having four substantially parallel conductive rods that are substantially coextensive in the axial direction. The rods include two diagonally arranged pairs including one continuous, rod pair and one pair of rods that are segmented such that the two segments in a rod are capacitively coupled to facilitate an RF drop when an RF signal is applied to one longer segment and capacitively provided to the other shorter segment. An RF signal is provided to the continuous rods and tire longer segment of the segmented rods.
    Type: Grant
    Filed: September 23, 2016
    Date of Patent: August 13, 2019
    Assignee: DH Technologies Development Pte. Ltd.
    Inventor: Mircea Guna
  • Patent number: 10354855
    Abstract: An apparatus 41 and operation method are provided for an electrostatic trap mass spectrometer with measuring frequency of multiple isochronous ionic oscillations. For improving throughput and space charge capacity, the trap is substantially extended in one Z-direction forming a reproduced two-dimensional field. Multiple geometries are provided for trap Z-extension. The throughput of the analysis is improved by multiplexing electrostatic traps. The frequency analysis is accelerated by the shortening of ion packets and either by Wavelet-fit analysis of the image current signal or by using a time-of-flight detector for sampling a small portion of ions per oscillation. Multiple pulsed converters are suggested for optimal ion injection into electrostatic traps.
    Type: Grant
    Filed: December 10, 2018
    Date of Patent: July 16, 2019
    Assignee: LECO Corporation
    Inventor: Anatoly N. Verenchikov
  • Patent number: 10332736
    Abstract: An object of the invention is to provide a mass spectrometer system capable of obtaining a mass spectrum with high resolution as the mass number of an ion becomes higher. In the mass spectrometer system of the invention, a control unit 8 controls a mass spectrometry unit 4 so that a direct current voltage U, an amplitude V of a radio-frequency voltage, and a frequency F of the radio-frequency voltage, which are applied to a quadrupole electrode 13, are increased as a mass-to-charge ratio m/z of an ion of a target for mass spectrometry becomes larger. By controlling in this manner, the ion frequency when the ion passes through the inside of the mass spectrometry unit 4 is increased as the mass number of an ion becomes higher, and therefore, it is possible to obtain the mass spectrum with higher resolution.
    Type: Grant
    Filed: January 24, 2014
    Date of Patent: June 25, 2019
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Kiyomi Yoshinari, Yasushi Terui
  • Patent number: 10276357
    Abstract: A method is described that involves simplification of UVPD mass spectra and comprises selecting precursor ions for UVPD fragmentation, performing UVPD fragmentation on selected precursor ions to give UVPD fragment ions. PTR may then be performed on the UVPD fragment ions with optional ion parking to yield charge-state reduced UVPD fragment ions. The UVPD-PTR steps may be repeated above n times where n=1 to 50. Ion parking may enhance the intensity of selected lower fragment ion charge states or to increase the intensity of peaks in selected m/z ranges. After a number of PTR-UVPD iterations, fragment ions are mass analyzed. The method provides a way of simplifying UVPD mass spectral product ions by lowering fragment ion charge states and spreading out resulting product ions in m/z mass spectral space when compared to using UVPD fragmentation alone.
    Type: Grant
    Filed: December 20, 2017
    Date of Patent: April 30, 2019
    Assignee: THERMO FINNIGAN LLC
    Inventors: Vladimir Zabrouskov, Chad R. Weisbrod, Christopher Mullen, Seema Sharma
  • Patent number: 10204773
    Abstract: A first rod electrode set has a first center axis, into which ions and air current are introduced. A second rod electrode set has a second center axis at a distance from the first center axis, from which the ions are discharged. A power supply applies voltages to the first rod electrode set and the second rod electrode set. The first rod electrode set and the second rod electrode set have a region where the sets overlap each other in the longitudinal direction, and form a single multipole ion guide by being combined to each other in the region. Different offset DC voltages are applied to the first rod electrode set and the second rod electrode set, respectively, and a DC potential for moving the ions to the second rod electrode set in the region is formed, the ions having been guided by the first rod electrode set.
    Type: Grant
    Filed: February 23, 2015
    Date of Patent: February 12, 2019
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Masuyuki Sugiyama, Hideki Hasegawa, Masao Suga, Hiroyuki Satake, Yuichiro Hashimoto
  • Patent number: 10192730
    Abstract: A method of operating an electrostatic trapping mass analyzer, comprising: introducing a sample of ions into a trapping region of the mass analyzer, wherein a trapping field within the trapping region is such that the ions exhibit radial motion with respect to a central longitudinal axis of the trapping region while undergoing harmonic motion in a dimension defined by the central longitudinal axis, the frequency of harmonic motion of a particular ion being a function of its mass-to-charge ratio; superimposing a modulation field onto the trapping field within the trapping region, the modulation field acting to either increase or reduce the harmonic motion energies of the ions by an amount varying according to the frequency of harmonic motion; and acquiring a mass spectrum of the ions in the trapping region by measuring a signal representative of an image current induced by the harmonic motion of the ions.
    Type: Grant
    Filed: August 30, 2016
    Date of Patent: January 29, 2019
    Assignee: Thermo Finnigan LLC
    Inventors: Chad R. Weisbrod, Michael W. Senko, Jesse D. Canterbury, John E. P. Syka
  • Patent number: 10186413
    Abstract: An ion reflector has a configuration in which multiple plate electrodes having a rectangular opening are arranged. The components are arranged so that a central axial line extending in the longitudinal direction of the opening lies on a plane which contains a straight line (Y-axis) connecting the centroidal position of an ion distribution in an ion trap and a central position on the detection surface of a detector, and a central axial line (X-axis) of an ion-ejecting direction. If the potential distribution along the central axis of the ion reflector is modified so that a portion of the reflecting field becomes a non-uniform electric field intended for improving isochronism for a group of ions to be detected, an area having an ideal potential distribution for realizing the isochronism is spread in the Y-axis direction.
    Type: Grant
    Filed: December 24, 2014
    Date of Patent: January 22, 2019
    Assignee: SHIMADZU CORPORATION
    Inventor: Osamu Furuhashi
  • Patent number: 10163618
    Abstract: The invention proposes a mass spectrometry apparatus for ultraviolet light ionization of neutral lost molecules, and a method for operating same. The mass spectrometry apparatus for ultraviolet light ionization of neutral lost molecules includes a quadrupole tandem special linear ion trap mass analyzer, a vacuum ultraviolet lamp, a lamp front shutter, a gradient vacuum system and other necessary components for the mass spectrometry apparatus. In addition, the invention also proposes a method for operating the apparatus to efficiently store ions, fragment and analyze the ions, perform ultraviolet efficient ionization on lost neutral molecules, and then analyze the ions.
    Type: Grant
    Filed: November 19, 2015
    Date of Patent: December 25, 2018
    Assignee: NATIONAL INSTITUTE OF METROLOGY CHINA
    Inventors: Xingchuang Xiong, Xiang Fang, You Jiang, Xiaoyun Gong, Zejian Huang, Meiying Liu
  • Patent number: 10153146
    Abstract: The invention provides methods, systems and algorithms for identifying high-resolution mass spectra. In some embodiments, an analyte is ionized and analyzed using high-resolution mass spectrometry (MS) at high mass accuracy (such as ?75 ppm or ?30 ppm) and the obtained mass spectra are matched with one or more prospective candidate molecules or chemical formulas. The invention provide, for example, methods and systems wherein the possible fragments that can be generated from the candidate molecules or chemical formulas are determined as well as the masses of each of these fragments. The invention provide, for example, methods and systems wherein the high-resolution mass spectra are then compared with the calculated fragment masses for each of the candidate molecules or chemical formula, and the portion of the high-resolution mass spectra that corresponds or can be explained by the calculated fragment masses is determined.
    Type: Grant
    Filed: March 27, 2015
    Date of Patent: December 11, 2018
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Nicholas W. Kwiecien, Derek J. Bailey, Michael S. Westphall, Joshua J. Coon
  • Patent number: 10134574
    Abstract: A method of fragmenting ions is disclosed comprising providing a linear ion trap comprising: (i) a first electrode set comprising a plurality of first electrodes; (ii) a second electrode set arranged downstream of the first electrode set and comprising a plurality of second electrodes; and (iii) a third electrode set arranged downstream of the second electrode set and comprising a plurality of third electrodes. Ions are axially confined within the linear ion trap. Either: (i) a potential difference between at least some of the first electrodes and at least some of the second electrodes; and/or (ii) a potential difference between at least some of the second electrodes and at least some of the third electrodes, is varied in order to accelerate at least some ions confined within the linear ion trap in order to cause the ions to fragment so as to form fragment or daughter ions.
    Type: Grant
    Filed: March 21, 2016
    Date of Patent: November 20, 2018
    Assignee: MICROMASS UK LIMITED
    Inventors: Daniel James Kenny, Martin Raymond Green
  • Patent number: 10128094
    Abstract: A mass spectrometer includes a collision cell and a system controller. The collision cell includes a plurality of rod pairs configured to generate pseudopotential well through the application of radio frequency potentials to the rod pairs. The collision cell configured to generate a target fragment from a parent ion by colliding the parent ion with one or more gas molecules. The system controller is configured to set a radio frequency amplitude of the radio frequency potentials to a default amplitude; monitor the production of a target fragment ion while adjusting the collision energy; set the collision energy to optimize the production of the target fragment ion; apply a linear full range ramp to the radio frequency amplitude to determine an optimal radio frequency amplitude; and set the radio frequency amplitude to the optimal radio frequency amplitude for the parent ion, target fragment ion pair.
    Type: Grant
    Filed: March 1, 2017
    Date of Patent: November 13, 2018
    Assignee: THERMO FINNIGAN LLC
    Inventors: Bennett S. Kalafut, Harald Oser
  • Patent number: 10126265
    Abstract: The methods herein provide for analysis of ion populations. Certain aspects include: directing a continuous gas phase ion beam into an entrance of a drift tube configured within an ion mobility spectrometer; perturbing the flow of the continuous gas phase ion beam within a perturbation time range so as to cause one or more configured perturbations; configuring the drift tube to allow the one or more perturbations to separate due to the differences in mobilities; receiving the plurality of ions and the one or more perturbations at the entrance of a mass spectrometer; recording raw data indicative of the plurality of ions; and reconstructing the raw data to obtain one or more mass to charge and one or more ion mobility spectrum of the plurality of ions.
    Type: Grant
    Filed: March 2, 2017
    Date of Patent: November 13, 2018
    Assignee: WASHINGTON STATE UNIVERSITY
    Inventors: Wenjie Liu, Herbert H. Hill, Jr., William F. Siems
  • Patent number: 10109471
    Abstract: A sample inlet device and methods for use of the sample inlet device are described that include an ion funnel having a plurality of electrodes with apertures arranged about an axis extending from an inlet of the ion funnel to an outlet of the ion funnel, the ion funnel including a plurality of spacer elements disposed coaxially with the plurality of electrodes, each of the plurality of spacer elements being positioned between one or two adjacent electrodes, each of the plurality of spacer elements having an aperture with a diameter that is greater than a diameter of each adjacent electrode. The ion funnel is configured to pass an ion sample through the apertures of the electrodes and the spacer elements to additional portions of a detection system, such as to a mass analyzer system and detector.
    Type: Grant
    Filed: February 6, 2017
    Date of Patent: October 23, 2018
    Assignee: Smith Detection, Inc.
    Inventors: Vadym Berkout, Jan Hendrikse
  • Patent number: 10103013
    Abstract: Certain embodiments described herein are directed to collision cells that comprise one or more integrated lenses. In some examples, a lens is coupled to two sections of a sectioned quadrature rod assembly, the lens comprising an aperture and a plurality of separate conductive elements disposed each one side of the lens, in which a respective disposed conductive element on one side of the lens is configured to electrically couple to a first, second, third, and fourth pole segments of the sectioned quadrature rod assembly.
    Type: Grant
    Filed: May 15, 2016
    Date of Patent: October 16, 2018
    Assignee: PerkinElmer Health Sciences, Inc.
    Inventor: Urs Steiner
  • Patent number: 10062558
    Abstract: A technique for improving the efficiency of injecting ions into the electrode unit of a funnel structure having high ion-transport efficiency is provided to improve the overall ion-transport efficiency. From an ionization chamber 1 for ionizing a sample under atmospheric pressure, ions are injected through a straight capillary pipe 3 into the inner space of the electrode unit 10 of a funnel structure composed of ring electrodes in a first intermediate vacuum chamber 4. The space for setting the capillary pipe 3 is formed by replacing one or more ring electrodes with C-shaped electrodes whose circumference portion is partially removed. Each C-shaped electrode is arranged so that the ions will be injected perpendicularly to the ion-transport direction.
    Type: Grant
    Filed: January 25, 2011
    Date of Patent: August 28, 2018
    Assignee: Shimadzu Co.
    Inventor: Motohide Yasuno
  • Patent number: 10051722
    Abstract: When accelerating first ions, radio frequency power is fed to a drift tube linear accelerator so that the phase difference between an accelerating half cycle for accelerating the first ions in one of the plurality of drift tube gaps and the accelerating half cycle for accelerating the accelerated first ions reaching the next drift tube gap is set to a first accelerating cycle phase difference; and when accelerating second ions having a charge-to-mass ratio lower than the first ions, the radio frequency power is fed to the drift tube linear accelerator so that the phase difference between an accelerating half cycle for accelerating the second ions in the one drift tube gap and the accelerating half cycle for the accelerated second ions reaching the next drift tube gap is set to a second accelerating cycle phase difference that is larger than the first accelerating cycle phase difference.
    Type: Grant
    Filed: July 10, 2015
    Date of Patent: August 14, 2018
    Assignee: MITSUBISHI ELECTRIC CORPORATION
    Inventors: Kazuo Yamamoto, Sadahiro Kawasaki, Hiromitsu Inoue
  • Patent number: 10022152
    Abstract: An external fixation assembly for bone fusion or separation is disclosed. The assembly includes a fracture fusion tube, with a bracket slidably engaged thereon. The assembly further includes a collet clamp connected to the bracket, with a ball collet rotatably seated within the clamp, the ball collet having an aperture for receiving a bone bin therethrough and perforations for a compression engagement with a bone pin. The assembly uses a single screw for threadably engaging the ball collet, the clamp and the bracket such that the position of the bone pin, ball collet and bracket are all fixed.
    Type: Grant
    Filed: May 18, 2016
    Date of Patent: July 17, 2018
    Assignee: DNE, LLC
    Inventor: Nicholas Riccione
  • Patent number: 10020181
    Abstract: An ion transport optical system is disposed between a collision cell and an orthogonal acceleration unit. When releasing ions that are held in the collision cell, an accelerating electric field in which a large potential difference exists is created between an exit-side end of an ion guide and a first stage of the ion transport optical system, and a decelerating electric field in which a relatively small potential difference exists is created between a final stage of the ion transport optical system and an entrance end of the orthogonal acceleration unit. In the accelerating electric field, the velocity of ions is increased overall by imparting a large amount of energy to the ions, and spreading of ions in the ion travel direction that is caused by differences between the mass-to-charge ratios of the ions is reduced.
    Type: Grant
    Filed: August 19, 2014
    Date of Patent: July 10, 2018
    Assignee: SHIMADZU CORPORATION
    Inventor: Daisuke Okumura
  • Patent number: 10014168
    Abstract: An ion guiding device (3) and method, the ion guiding device (3) having: a group of electrode arrays distributed along an axis in space, and a power supply providing an asymmetric alternating current (AC) electric field substantially along the axis; the AC field asymmetrically alternates between positive and negative along the axis to drive the ions move in the direction corresponding to said AC electric field such that ions are guided into said ion guiding device (3) in a continuous or quasi-continuous flow manner while being guided out in a pulsed manner along the axis.
    Type: Grant
    Filed: March 26, 2014
    Date of Patent: July 3, 2018
    Assignee: SHIMADZU RESEARCH LABORATORY (SHANGHAI) CO., LTD.
    Inventors: Xiaoqiang Zhang, Wenjian Sun
  • Patent number: 10002741
    Abstract: An electron microscope includes a stage, a charged particle beam generator, a plurality of elemental spectrum detectors and a reader. The stage is configured for carrying a sample. The charged particle beam generator is configured for generating a charged particle beam to bombard the sample. The elemental spectrum detectors is configured for detecting X ray emitted from the sample being bombarded by the charged particle beam and outputting a plurality of corresponding spectrum detecting signals. The reader is configured for calibrating a plurality of counting signals generated by the spectrum detecting signals and summing the calibrated counting signals to obtain an elemental spectrum of the sample. The collection time of elemental spectrum of the above-mentioned electron microscope can be shortened. A reader and an acquiring elemental spectrum method applied to the above-mentioned electron microscope are also disclosed.
    Type: Grant
    Filed: December 26, 2014
    Date of Patent: June 19, 2018
    Assignee: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
    Inventors: Fu-Rong Chen, Tsu-Wei Huang, Chin-Liang Hsu