Laterally Resonant Ion Path Patents (Class 250/292)
  • Patent number: 11480544
    Abstract: Apparatus comprise an electrode arrangement comprising a plurality of electrodes defining a volume, an ion entrance, and an ion exit, and a voltage source coupled to the plurality of electrodes and configured to apply a nonlinear DC voltage sequence to the electrodes between the ion entrance and the ion exit that directs ions through the volume with the volume at a pressure of at least 1 Torr. Ions can be focused using nonlinear DC voltage sequences, including at atmospheric pressure. Related methods are also disclosed.
    Type: Grant
    Filed: February 5, 2020
    Date of Patent: October 25, 2022
    Assignee: Battelle Memorial Institute
    Inventors: Adam L. Hollerbach, Yehia M. Ibrahim, Sandilya V. B. Garimella
  • Patent number: 11443933
    Abstract: An inductively coupled plasma-mass spectrometry (ICP-MS) system includes an ion trap, in which ions are trapped and subsequent ejected by mass-selective ejection (MSE). The system may have a linear quadrupole configuration, in which the ion trap is a linear ion trap (LIT) that is preceded by a pre-LIT linear quadrupole device and/or a post-LIT quadrupole device. The pre-LIT and/or post-LIT quadrupole device may be configured or operated as an RF-only ion guide or as a mass filter or mass analyzer, with or without mass scanning. The system may be utilized in particular for multi-element analysis of fast transient signals produced from ion pulses, where the sample under analysis is a single particle, single biological cell, or a cloud or aerosol produced for example by single-shot laser ablation.
    Type: Grant
    Filed: November 23, 2020
    Date of Patent: September 13, 2022
    Assignee: Agilent Technologies, Inc.
    Inventor: Noriyuki Yamada
  • Patent number: 11436518
    Abstract: A method of performing an entangling operation between two trapped ions in a quantum computer includes selecting a gate duration value of a pulse to be applied to a first ion and a second ion in a chain of trapped ions, determining one or more tones of the pulse, each tone comprising an amplitude value and a detuning frequency value, based on the selected gate duration value and frequencies of the motional modes of the chain of trapped ions, generating the pulse having the one or more tones, each tone comprising the determined amplitude and the determined detuning frequency values, and applying the generated pulse to the first and second ions for the gate duration value. Each of the trapped ions has two frequency-separated states defining a qubit, and motional modes of the chain of trapped ions each have a distinct frequency.
    Type: Grant
    Filed: September 20, 2019
    Date of Patent: September 6, 2022
    Assignee: IONQ, INC.
    Inventors: Yunseong Nam, Reinhold Blumel, Nikodem Grzesiak
  • Patent number: 11385202
    Abstract: A mass spectrometer is disclosed comprising an ion mobility spectrometer or separator and an ion guide arranged downstream of the ion mobility spectrometer or separator. A plurality of axial potential wells are created in the ion guide so that ions received from the ion mobility spectrometer or separator become confined in separate axial potential wells. The potential wells maintain the fidelity and/or composition of ions received from the ion mobility spectrometer or separator. The potential wells are translated along the length of the ion guide.
    Type: Grant
    Filed: July 13, 2020
    Date of Patent: July 12, 2022
    Assignee: Micromass UK Limited
    Inventors: Robert Harold Bateman, Kevin Giles, Steven Derek Pringle, Jason Lee Wildgoose
  • Patent number: 11373852
    Abstract: Aspects of the present disclosure describe techniques for mitigating charging on optical windows. For example, a device for mitigating charges inside a chamber of a trapped ion system is described that includes an array of parallel wires formed from a single, conductive plate by cutting elongated gaps through an entire thickness of the conductive plate that separate the wires, an outer portion of the conductive plate to which the wires are attached is configured to position the wires to run parallel to one or more trapped ions in the chamber and to position the wires between a dielectric component of the chamber and the one or more trapped ions. A chamber with such an array of parallel wires and a method of using such an array of parallel wires are also described.
    Type: Grant
    Filed: June 23, 2020
    Date of Patent: June 28, 2022
    Assignee: IONQ, INC.
    Inventors: Jonathan Albert Mizrahi, Kenneth Wright, Jason Madjdi Amini
  • Patent number: 11348778
    Abstract: The invention generally relates to systems and methods for precursor and neutral loss scan in an ion trap. In certain aspects, the invention provides a system that includes a mass spectrometer having an ion trap, and a central processing unit (CPU). The CPU includes storage coupled to the CPU for storing instructions that when executed by the CPU cause the system to excite a precursor ion and eject a product ion in the single ion trap.
    Type: Grant
    Filed: November 2, 2016
    Date of Patent: May 31, 2022
    Assignee: Purdue Research Foundation
    Inventors: Robert Graham Cooks, Dalton Snyder, Christopher Pulliam
  • Patent number: 11336290
    Abstract: Control of an amplitude of a signal applied to rods of a quadrupole is described. In one aspect, a mass spectrometer includes an amplifier circuit that causes a radio frequency (RF) signal to be applied to the rods of the quadrupole based on an amplifier RF input signal. An analog-to-digital converter (ADC) can generate a digital representation of the RF signal. A controller circuit can receive the digital representation and adjust an amplitude of the amplifier RF input signal based on differences between an amplitude of a fundamental frequency of the RF signal being different than an expected amplitude.
    Type: Grant
    Filed: March 30, 2020
    Date of Patent: May 17, 2022
    Assignee: Thermo Finnigan LLC
    Inventors: Johnathan W. Smith, Scott T. Quarmby, Dustin J. Kreft, Michael W. Senko
  • Patent number: 11295928
    Abstract: The invention provides a multi-pole deflector for a charged particle beam, and a charged particle beam imaging apparatus. The deflector includes a plurality of poles, including at least two pairs of poles, each pole in each pair of poles including a main body constructed in the form of a circular arc-shaped section and a protrusion projecting from an radial inner side of the main body.
    Type: Grant
    Filed: August 28, 2020
    Date of Patent: April 5, 2022
    Assignee: Zhongke Jingyuan Electron Limited, Beijing (CN)
    Inventors: Qinglang Meng, Weiqiang Sun, Yan Zhao
  • Patent number: 11270874
    Abstract: Control of an amplitude of a signal applied to rods of a quadrupole is described. In one aspect, a mass spectrometer includes an amplifier circuit that causes a radio frequency (RF) signal to be applied to the rods of the quadrupole. A controller circuit can determine that the actual amplitude of the RF signal differs than the expected amplitude and, in response, identify current and past environmental and performance parameters to adjust the amplitude.
    Type: Grant
    Filed: March 30, 2020
    Date of Patent: March 8, 2022
    Assignee: Thermo Finnigan LLC
    Inventors: Johnathan W. Smith, Scott T. Quarmby, Dustin J. Kreft, Michael W. Senko
  • Patent number: 11264225
    Abstract: Certain configurations of devices are described herein that include DC multipoles that are effective to direct ions. In some instances, the devices include a first multipole configured to provide a DC electric field effective to direct first ions of an entering particle beam along a first exit trajectory that is substantially orthogonal to an entry trajectory of the particle beam. The devices may also include a second multipole configured to provide a DC electric field effective to direct the received first ions from the first multipole along a second exit trajectory that is substantially orthogonal to the first exit trajectory.
    Type: Grant
    Filed: July 23, 2020
    Date of Patent: March 1, 2022
    Assignee: PerkinElmer Health Sciences Canada, Inc.
    Inventors: Kaveh Kahen, Hamid Badiei
  • Patent number: 11264220
    Abstract: A method for producing an atom trap (20) comprising the steps: (a) applying an electrically conductive starting layer (2) onto a substrate (1), (b) applying at least one electric conductor element (4) to the starting layer (2) by means of electro-chemical deposition and/or a lift-off method, (c) applying at least one contacting element (6) by means of electro-chemical deposition and/or a lift-off method, such that the at least one contacting element (6) is connected to the at least one electric conductor element (4) in an electrically conductive manner, (d) removing the starting layer (2) in regions in which no electric conductor element (4) has been applied, (e) applying an insulation layer (7) that at least partially covers the at least one electric conductor element (4) and the at least one contacting element (6), (f) planarizing the insulation layer (7) and exposing the at least one contacting element (6), and (g) applying at least one additional electric conductor (14) element by means of electro-chemica
    Type: Grant
    Filed: March 4, 2019
    Date of Patent: March 1, 2022
    Assignee: Bundesrepublik Deutschland, vertreten durch das Bundesministerium fuer Wirtschaft und Energie, dieses vertreten durch den Praesidenten der Physikalisch-Technischen Bundesanstalt
    Inventors: Amado Bautista-Salvador, Christian Ospelkaus, Martina Wahnschaffe, Jonathan Morgner
  • Patent number: 11222777
    Abstract: Disclosed herein is an ion guide for guiding an ion beam along an ion path, said ion guide having a longitudinal axis corresponding to said ion path, said ion guide-comprising a plurality of elongate electrodes arranged around and extending along said longitudinal axis wherein an inner envelope of the plurality of electrodes defines an ion guide volume. Said elongate electrodes are formed by electrode wires, wherein adjacent electrode wires are arranged at an inter-wire distance. The ion guide comprises holding structures for supporting and for straightening the electrode wires by applying a tension or maintaining a tension applied to them. Any portion of said holding structures which is separated from said ion guide volume by less than the local inter-wire distance is made from a material having a resistivity of less than 1012 Ohm·cm, preferably of less than 109 Ohm·cm, or has a sheet resistivity of less than 1014 Ohm, preferably of less than 1010 Ohm on a surface facing said ion guide volume.
    Type: Grant
    Filed: April 5, 2019
    Date of Patent: January 11, 2022
    Assignee: TECHNISCHE UNIVERSITÄT MÜNCHEN
    Inventors: Tobias Kaposi, Hartmut Schlichting, Johannes Barth, Andreas Walz
  • Patent number: 11189478
    Abstract: Four rod electrodes (50a to 50d) for separating ions according to a mass-to-charge ratio are held by a rod holder (51). The rod holder (51) is placed on a metal holder sustaining stand (52) provided on a bottom surface of a vacuum housing (1), and is fixed while being pressed by a fixation band (53) fixed to the holder sustaining stand (52) with screws (56). The fixation band (53) has a coating film layer (532) formed by a black nickel plating process on the entire surface of a main member (531) made from phosphor bronze. The coating film layer (532) has high emissivity, and thus heat transferred from the rod holder (51) to the fixation band (53) is efficiently radiated into the vacuum housing (1). Therefore, heat generated in the rod holder (51) due to dielectric loss is efficiently dissipated, and deformation of the rod holder can be reduced.
    Type: Grant
    Filed: February 7, 2018
    Date of Patent: November 30, 2021
    Assignee: SHIMADZU CORPORATION
    Inventors: Manabu Ueda, Kota Nagasao
  • Patent number: 11152199
    Abstract: An ion optic assembly includes a set of conductive rods, a first insulator, and a second insulator. The rods are inserted into through-holes of the first insulator, which are arranged about an axis along which the rods are elongated. The rods are then inserted through a bore of the second insulator and become located in notches of the bore, which are arranged about the axis. Accordingly, the first insulator positions one end of the rods at a first distance from the axis, and the second insulator positions the other end of the rods at a second distance from the axis, which may equal to or different from the first distance. The rods contact, and may be spring-biased against, the notches. The assembly may include an electrical contact with fingers spring-biased into contact with the rods. Each insulator may include both through-holes and notches for additional rods.
    Type: Grant
    Filed: December 17, 2019
    Date of Patent: October 19, 2021
    Assignee: Agilent Technologies, Inc.
    Inventors: Robert M. Roberts, James L. Bertsch
  • Patent number: 11114292
    Abstract: A linear ion trap system includes a linear ion trap having at least two discrete trapping regions for processing ions. An RF electrical potential generator produces two RF waveforms applied to a pair of pole electrodes of the linear ion trap forming a RF trapping field component to trap ions radially. A multi-output DC electrical potential generator produces a first set of multiple DC field components superimposed to the RF trapping field component and distributed across the length of the linear ion trap to control ions axially. A control unit is configured to switch the DC electrical potentials and DC field components collectively forming a first trapping region of the at least two discrete trapping regions that is populated with ions to alter ion potential energy from a first level to a second level, and to enable at least a first ion processing step in at least one of the first and second levels.
    Type: Grant
    Filed: July 10, 2019
    Date of Patent: September 7, 2021
    Assignee: FASMATECH SCIENCE & TECHNOLOGY LTD.
    Inventors: Dimitris Papanastasiou, Emmanuel Raptakis
  • Patent number: 11114293
    Abstract: A space-time buffer includes a plurality of discrete trapping regions and a controller. The plurality of discrete trapping regions is configured to trap ions as individual trapping regions or as combinations of trapping regions. The controller is configured to combine at least a portion of the plurality of trapping regions into a larger trap region; fill the larger trap region with a plurality of ions; split the larger trap region into individual trapping regions each containing a portion of the plurality of ions; and eject ions from the trapping regions.
    Type: Grant
    Filed: December 11, 2019
    Date of Patent: September 7, 2021
    Assignee: THERMO FINNIGAN LLC
    Inventors: Philip M. Remes, Michael W. Senko
  • Patent number: 11062895
    Abstract: A method of operating a mass spectrometer, comprising: generating ions from a sample; mass filtering the ions using a quadrupole mass filter having a set of selection parameters to transmit ions within at least one selected range of mass-to-charge ratios narrower than an initial range, wherein the quadrupole comprises four parallel elongate electrodes arranged in opposing pairs to which are applied RF and DC, wherein an attractive DC voltage is applied to one pair of opposing electrodes and a repulsive DC voltage is applied to the other pair; mass analysing or detecting the ions transmitted by the quadrupole mass filter; repeating the steps of generating ions, mass filtering and mass analysing or detecting multiple times; switching a configuration of the pairs of opposing electrodes to which the attractive DC voltage and the repulsive DC voltage are applied multiple times over the course of repeating the steps so that over long term operation the build-up of contamination on each pair of opposing electrodes i
    Type: Grant
    Filed: April 8, 2020
    Date of Patent: July 13, 2021
    Assignee: Thermo Fisher Scientific (Bremen) GmbH
    Inventors: Amelia Corinne Peterson, Jan-Peter Hauschild, Oliver Lange, Alexander A. Makarov
  • Patent number: 11049713
    Abstract: Various embodiments provide methods, apparatuses, systems, or computer program products for deterministically reordering a group of atomic objects within an atomic object confinement apparatus. The group of atomic objects comprises Object A, Object B, Object C, and Object D, where Object B and Object C are of a first atomic type, and Object A and Object D are not of the first atomic type. The atomic object confinement apparatus comprises a plurality of potential generating elements which are controlled to create a time-dependent potential field within the atomic object confinement apparatus. The time-dependent potential field experienced by the group of atomic objects causes Object A, Object B, Object C, and Object D to move along corresponding reordering trajectories such that the group of atomic objects is deterministically reshaped and/or reordered.
    Type: Grant
    Filed: May 12, 2020
    Date of Patent: June 29, 2021
    Assignee: Honeywell International Inc.
    Inventors: Mark Kokish, Nathaniel Burdick, James Hostetter, Daniel Gresh
  • Patent number: 11043371
    Abstract: Four rod electrodes (50a to 50d) for separating ions according to a mass-to-charge ratio are held by two rod holders (51). The rod holders (51) are attached to metal holder sustaining stands (52) provided on a bottom surface of a vacuum housing (1). A coating film layer (10) is formed by a black nickel plating process on parts of wall surfaces in the vacuum housing (1), an inlet lens (4), and an outlet lens (6), the parts facing a quadrupole mass filter unit (5). The emissivity of the coating film layer (10) is higher than that of Al or the like, and thus radiant heat from the quadrupole mass filter unit (5) is efficiently absorbed by the coating film layer (10). Therefore, heat generated in the rod holders (51) due to dielectric loss is efficiently dissipated, and deformation of the rod holders can be reduced.
    Type: Grant
    Filed: February 7, 2018
    Date of Patent: June 22, 2021
    Assignee: SHIMADZU CORPORATION
    Inventors: Manabu Ueda, Kota Nagasao
  • Patent number: 11037775
    Abstract: An ion guide is disclosed comprising a first array of electrodes and a second array of electrodes and one or more apertures or ion exit regions. The first array of electrodes comprises a first plurality of arcuate electrodes arranged in parallel with one another and such that said first plurality of arcuate electrodes at least partially surround said one or more apertures or ion exit regions and/or wherein said second array of electrodes comprises a second plurality of arcuate electrodes arranged in parallel with one another and such that said second plurality of arcuate electrodes at least partially surround said one or more apertures or ion exit regions.
    Type: Grant
    Filed: June 9, 2015
    Date of Patent: June 15, 2021
    Assignee: Micromass UK Limited
    Inventors: Kevin Giles, Jason Lee Wildgoose, Martin Raymond Green
  • Patent number: 11017994
    Abstract: An ion guide is disclosed that comprises a plurality of electrodes arranged to form a multipole ion guide and one or more rigid support members. The plurality of electrodes comprises one or more groups of electrodes, and each group of electrodes comprises plural electrodes that are axially spaced apart from one another. The electrodes of one or more groups of electrodes are attached to one of the one or more rigid support members. One or more of the electrodes comprises a curved metal sheet, plate or strip.
    Type: Grant
    Filed: July 6, 2018
    Date of Patent: May 25, 2021
    Assignee: MICROMASS UK LIMITED
    Inventors: Oliver John Malpas, James Paul Harrison, Bharat Chande, John Iveson
  • Patent number: 10991564
    Abstract: The invention generally relates to mass spectrometry probes and systems for ionizing a sample. In certain embodiments, the invention provides a mass spectrometry probe including a substrate in which a portion of the substrate is coated with a material, a portion of which protrudes from the substrate.
    Type: Grant
    Filed: January 2, 2020
    Date of Patent: April 27, 2021
    Assignee: Purdue Research Foundation
    Inventors: Robert Graham Cooks, Depanjan Sarkar, Thalappil Pradeep, Rahul Narayanan
  • Patent number: 10984997
    Abstract: A switch circuit is turned ON and switch circuits are turned OFF to apply a negative direct-current voltage from a negative voltage generating unit to a flight tube, and while a measurement is conducted, a switch circuit is turned ON, and a capacitor is charged by an auxiliary positive voltage generating unit. When the polarity of the applied voltage is switched from negative to positive, the switch circuit is turned OFF and the switch circuit is turned ON to supply a large current from the capacitor to the flight tube, thus the capacitance of the flight tube is charged to a positive potential quickly. After that, the switch circuit is turned OFF and the switch circuit is turned ON to apply a stable positive direct-current voltage from a positive voltage generating unit to the flight tube.
    Type: Grant
    Filed: October 4, 2016
    Date of Patent: April 20, 2021
    Assignee: SHIMADZU CORPORATION
    Inventor: Yasushi Aoki
  • Patent number: 10978288
    Abstract: A miniature mass spectrometer is disclosed comprising an atmospheric pressure ionisation source 701, a first vacuum chamber having an atmospheric pressure sampling orifice or capillary, a second vacuum chamber located downstream of the first vacuum chamber and a third vacuum chamber located downstream of the second vacuum chamber. A first vacuum pump 707 is arranged and adapted to pump the first vacuum chamber, wherein the first vacuum pump is arranged and adapted to maintain the first vacuum chamber at a pressure <10 mbar. A first RF ion guide 702 is located within the first vacuum chamber and an ion detector 705 is located in the third vacuum chamber. The ion path length from the atmospheric pressure sampling orifice or capillary to an ion detecting surface of the ion detector 705 is ?400 mm.
    Type: Grant
    Filed: August 15, 2019
    Date of Patent: April 13, 2021
    Assignee: Micromass UK Limited
    Inventors: David Gordon, Daniel James Kenny
  • Patent number: 10957525
    Abstract: A method of mass and/or ion mobility spectrometry is disclosed that comprises accumulating ions for a first period of time (T1) one or more times so as to form one or more first groups of ions, accumulating ions for a second period of time (T2) one or more times so as to form one or more second groups of ions, wherein the second period of time (T2) is less that the first period of time (T1), analysing the one or more first groups of ions to generate one or more first data sets, analysing the one or more second groups of ions to generate one or more second data sets, and determining whether the one or more first data sets comprise saturated and/or distorted data. If it is determined that the one or more first data sets comprise saturated and/or distorted data, then the method further comprises replacing the saturated and/or distorted data from the one or more first data sets with corresponding data from the one or more second data sets.
    Type: Grant
    Filed: December 24, 2019
    Date of Patent: March 23, 2021
    Assignee: Micromass UK Limited
    Inventors: Martin Raymond Green, Jason Lee Wildgoose, Steven Derek Pringle, Kevin R. Howes
  • Patent number: 10937640
    Abstract: A miniature electrode apparatus is disclosed for trapping charged particles, the apparatus includes, along a longitudinal direction, a first end cap electrode, a central electrode having an aperture, and a second end cap electrode. The aperture is elongated in the lateral plane and extends through the central electrode along the longitudinal direction and the central electrode surrounds the aperture in a lateral plane perpendicular to the longitudinal direction to define a transverse cavity for trapping charged particles. Electric fields can be applied in a y-direction of the lateral plane across one or more planes perpendicular to the longitudinal axis to translocate and/or manipulate ion trajectories.
    Type: Grant
    Filed: March 25, 2019
    Date of Patent: March 2, 2021
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: John Michael Ramsey, Andrew Hampton, Kevin Schultze
  • Patent number: 10930487
    Abstract: Certain configurations of devices are described herein that include a DC multipole that is effective to doubly bend the ions in an entering particle beam. In some instances, the devices include a first multipole configured to provide a DC electric field effective to direct first ions of an entering particle beam along a first internal trajectory at an angle different from the entry trajectory of the particle beam. The first multipole may also be configured to direct the ions in the first multipole along a second internal trajectory that is different than the angle of the first internal trajectory of the particle beam.
    Type: Grant
    Filed: August 9, 2019
    Date of Patent: February 23, 2021
    Assignee: PerkinElmer Health Sciences Canada, Inc.
    Inventors: Hamid Badiei, Samad Bazargan
  • Patent number: 10840077
    Abstract: An ion transfer device that receives ions from an ion inlet and delivers the ions to an ion outlet of the ion transfer device, the ion transfer device including: a plurality of electrodes disposed at least in part inside an enclosure such that one or more electrodes of the plurality of electrodes are configured to be flexible or flexibly connected to each other, and such that the ion transfer device is configured to be flexible and is configured to form one or more curvatures while transferring the ions.
    Type: Grant
    Filed: July 12, 2018
    Date of Patent: November 17, 2020
    Assignee: Trace Matters Scientific LLC
    Inventor: Mazdak Taghioskoui
  • Patent number: 10832900
    Abstract: A mass filter is disclosed having at least one electrode (42-48) comprising an aperture (43) or recess. Voltages are applied to the electrodes (42-48) of the mass filter such that ions having mass to charge ratios in a desired range are confined by the electrodes and are transmitted along and through the mass filter, whereas ions (47,49) having mass to charge ratios outside of said desired range are unstable and pass into the aperture (43) or recess such that they are filtered out by the mass filter. The aperture (43) or recess reduces or eliminates the number of ions that would otherwise impact the electrode surface facing the ion transmission axis and hence reduces degradation of the ion transmission properties of the mass filter.
    Type: Grant
    Filed: September 6, 2019
    Date of Patent: November 10, 2020
    Assignee: Micromass UK Limited
    Inventors: Martin Green, Jason Wildgoose, Keith Richardson, Kevin Giles, Daniel Kenny, David Langridge, Richard Moulds
  • Patent number: 10811243
    Abstract: Disclosed herein is an ion supply system, having an ion source emitting ions into a fore vacuum chamber, an ion transport device having stacked electrodes arranged in the fore vacuum chamber, a control system supplying an oscillatory voltage to the electrodes of the ion transport device and a vacuum chamber, arranged downstream from the ion transport device. A vacuum gauge is arranged in the vacuum chamber. The pressure signal of the vacuum gauge is supplied to the control system supplying the oscillatory voltage to electrodes of the ion transport device. The control system adjusts the amplitude of the oscillatory voltage in accordance with the pressure signal.
    Type: Grant
    Filed: December 19, 2018
    Date of Patent: October 20, 2020
    Assignee: Thermo Fisher Scientific (Bremen) GMBH
    Inventors: Amelia Corinne Peterson, Denis Chernyshev, Jan-Peter Hauschild, Erik Couzijn
  • Patent number: 10804089
    Abstract: A switch for coupling a first ion manipulation device to a second ion manipulation device comprises a first surface and a second surface, at least one first electrode coupled to each of the first and second surface and configured to receive a first voltage and generate a first potential, and at least one second electrode coupled to each of the first and second surface and configured to receive a second voltage and generate a second potential, wherein the first potential inhibits the motion of ions along a first direction and the second potential inhibits the motion of ions along a second direction different from the first direction.
    Type: Grant
    Filed: July 11, 2018
    Date of Patent: October 13, 2020
    Assignee: Batelle Memorial Institute
    Inventors: Yehia M. Ibrahim, Richard D. Smith
  • Patent number: 10796893
    Abstract: RF ion guides are configured as an array of elongate electrodes arranged symmetrically about a central axis, to which RF voltages are applied. The RF electrodes include at least a portion of their length that is semi-transparent to electric fields. Auxiliary electrodes are then provided proximal to the RF electrodes distal to the ion guide axis, such that application of DC voltages to the auxiliary electrodes causes an auxiliary electric field to form between the auxiliary electrodes and the ion guide RF electrodes. A portion of this auxiliary electric field penetrates through the semi-transparent portions of the RF electrodes, such that the potentials within the ion guide are modified. The auxiliary electrode structures and voltages can be configured so that a potential gradient develops along the ion guide axis due to this field penetration, which provides an axial motive force for collision damped ions.
    Type: Grant
    Filed: October 3, 2019
    Date of Patent: October 6, 2020
    Assignee: PerkinElmer Health Sciences, Inc.
    Inventor: David G. Welkie
  • Patent number: 10770279
    Abstract: An ion transfer apparatus for transferring ions from an ion source at an ion source pressure, which ion source pressure is greater than 500 mbar, along a path towards a mass analyser at a mass analyser pressure that is lower than the ion source pressure. The apparatus includes a plurality of pressure controlled chambers, wherein each pressure controlled chamber in the ion transfer apparatus includes an ion inlet opening for receiving ions from the ion source on the path and an ion outlet opening for outputting the ions on the path. The plurality of pressure controlled chambers are arranged in succession along the path from an initial pressure controlled chamber to a final pressure controlled chamber, wherein an ion outlet opening of each pressure controlled chamber other than the final pressure controlled chamber is in flow communication with the ion inlet opening of a successive adjacent pressure controlled chamber.
    Type: Grant
    Filed: October 20, 2016
    Date of Patent: September 8, 2020
    Assignee: SHIMADZU CORPORATION
    Inventors: Roger Giles, Alina Giles
  • Patent number: 10724990
    Abstract: A mass spectrometer is disclosed comprising an ion mobility spectrometer or separator and an ion guide arranged downstream of the ion mobility spectrometer or separator. A plurality of axial potential wells are created in the ion guide so that ions received from the ion mobility spectrometer or separator become confined in separate axial potential wells. The potential wells maintain the fidelity and/or composition of ions received from the ion mobility spectrometer or separator. The potential wells are translated along the length of the ion guide.
    Type: Grant
    Filed: August 8, 2016
    Date of Patent: July 28, 2020
    Assignee: MICROMASS UK LIMITED
    Inventors: Robert Harold Bateman, Kevin Giles, Steven Derek Pringle, Jason Lee Wildgoose
  • Patent number: 10727038
    Abstract: Certain configurations of devices are described herein that include DC multipoles that are effective to direct ions. In some instances, the devices include a first multipole configured to provide a DC electric field effective to direct first ions of an entering particle beam along a first exit trajectory that is substantially orthogonal to an entry trajectory of the particle beam. The devices may also include a second multipole configured to provide a DC electric field effective to direct the received first ions from the first multipole along a second exit trajectory that is substantially orthogonal to the first exit trajectory.
    Type: Grant
    Filed: January 20, 2019
    Date of Patent: July 28, 2020
    Assignee: PerkinElmer Health Sciences Canada, Inc.
    Inventors: Kaveh Kahen, Hamid Badiei
  • Patent number: 10707066
    Abstract: Four main rod electrodes included in a main electrode section are disposed in a rotationally symmetric manner around an ion optical axis. Among four pre-rod electrodes included in a pre-electrode section disposed in front of the main electrode section, two are in contact with a circle of a radius r0, whereas the other two are disposed to be in contact with a circle of a radius R0 larger than r0, resulting in rotational asymmetry around the ion optical axis. Accordingly, a shape of acceptance on an x-y plane regarding positions of ions in the pre-electrode section becomes elliptical. This allows the shape of the acceptance to become gradually flat as the ions travel along the ion optical axis, reducing a mismatch between emittance of incoming ions and the acceptance on a receiving side, and relieving ion loss during ion introduction.
    Type: Grant
    Filed: December 2, 2015
    Date of Patent: July 7, 2020
    Assignee: SHIMADZU CORPORATION
    Inventors: Shinji Miyauchi, Hiroko Ueda, Yoshihiro Ueno
  • Patent number: 10622202
    Abstract: The invention generally relates to ion traps that operate by applying an inverse Mathieu q scan. In certain embodiments, the invention provides systems that include a mass spectrometer having an ion trap and a central processing unit (CPU). The CPU includes storage coupled to the CPU for storing instructions that when executed by the CPU cause the system to apply an inverse Mathieu q scan to the ion trap.
    Type: Grant
    Filed: October 20, 2017
    Date of Patent: April 14, 2020
    Assignee: Purdue Research Foundation
    Inventors: Robert Graham Cooks, Dalton Snyder
  • Patent number: 10615018
    Abstract: Certain embodiments described herein are directed to collision cells that comprise one or more integrated lenses. In some examples, a lens is coupled to two sections of a sectioned quadrature rod assembly, the lens comprising an aperture and a plurality of separate conductive elements disposed each one side of the lens, in which a respective disposed conductive element on one side of the lens is configured to electrically couple to a first, second, third, and fourth pole segments of the sectioned quadrature rod assembly.
    Type: Grant
    Filed: September 28, 2018
    Date of Patent: April 7, 2020
    Assignee: PerkinElmer Health Sciences, Inc.
    Inventor: Urs Steiner
  • Patent number: 10566169
    Abstract: A charged particle buncher includes a series of spaced apart electrodes arranged to generate a shaped electric field. The series includes a first electrode, a last electrode and one or more intermediate electrodes. The charged particle buncher includes a waveform device attached to the electrodes and configured to apply a periodic potential waveform to each electrode independently in a manner so as to form a quasi-electrostatic time varying potential gradient between adjacent electrodes and to cause spatial distribution of charged particles that form a plurality of nodes and antinodes. The nodes have a charged particle density and the antinodes have substantially no charged particle density, and the nodes and the antinodes are formed from a charged particle beam with an energy less than or equal to 500 keV.
    Type: Grant
    Filed: June 30, 2009
    Date of Patent: February 18, 2020
    Assignee: NexGen Semi Holding, Inc.
    Inventors: Mark Joseph Bennahmias, Michael John Zani, Jeffrey Winfield Scott
  • Patent number: 10559455
    Abstract: The invention generally relates to mass spectrometry probes and systems for ionizing a sample. In certain embodiments, the invention provides a mass spectrometry probe including a substrate in which a portion of the substrate is coated with a material, a portion of which protrudes from the substrate.
    Type: Grant
    Filed: July 19, 2019
    Date of Patent: February 11, 2020
    Assignee: Purdue Research Foundation
    Inventors: Robert Graham Cooks, Depanjan Sarkar, Thalappil Pradeep, Rahul Narayanan
  • Patent number: 10553415
    Abstract: An ion manipulation device is disclosed comprising: an ion receiving region (30) for receiving ions; a pair of electrodes (14,16) adjacent the ion receiving region (30); and an AC or RF voltage supply (18) arranged to apply an AC or RF voltage to said electrodes (14,16), or arranged and configured to generate an electromagnetic field that couples to said electrodes (14,16) in use, such that an electromagnetic standing wave (24) is generated between said electrodes (14,16). A first of the electrodes (14) comprises one or more apertures through which an electric field from the standing wave (24) penetrates and enters the ion receiving region (30), in use, for urging said ions away from the one or more apertures.
    Type: Grant
    Filed: July 5, 2017
    Date of Patent: February 4, 2020
    Assignee: Micromass UK Limited
    Inventor: John Brian Hoyes
  • Patent number: 10504712
    Abstract: A mass spectrometry device comprises a reaction gas introduction device and a gas phase molecule-ion reaction mass spectrometry analysis device, wherein the reaction gas introduction device is connected to the gas phase molecule-ion reaction mass spectrometry analysis device; the reaction gas introduction device is configured to introduce reaction gas into the gas phase molecule-ion reaction mass spectrometry analysis device; and the gas phase molecule-ion reaction mass spectrometry analysis device is configured to enable molecules or ions to be subjected to a reaction and carry out mass spectrometry analysis on a reaction result. The reaction gas introduction device comprises a reaction gas container, the reaction gas container being configured to contain gas or volatile liquid or solid and generate gas molecules needed by a reaction; and a reaction gas quantitation device, configured to carry out flow control on the gas molecules.
    Type: Grant
    Filed: March 23, 2016
    Date of Patent: December 10, 2019
    Assignee: National Institute of Metrology, China
    Inventors: You Jiang, Xiang Fang, Xing-Chuang Xiong, Ze-Jian Huang
  • Patent number: 10497551
    Abstract: An ion storage device is provided which is arranged and adapted: (i) to receive first ions which have been temporally separated according to a first physico-chemical property during a first cycle of operation; (ii) to store the first ions in a first plurality of separate sections of the ion storage device so that first ions having different first physico-chemical properties are stored in different sections of the ion storage device; (iii) to receive second ions which have been temporally separated according to the first physico-chemical property during a second subsequent cycle of operation; and (iv) to store the second ions in the ion storage device so that the first and second ions are simultaneously stored within the ion storage device and so that at least some of the first and second ions having substantially the same first physico-chemical property are stored in the same section of the ion storage device.
    Type: Grant
    Filed: December 18, 2014
    Date of Patent: December 3, 2019
    Assignee: Micromass UK Limited
    Inventor: Jason Lee Wildgoose
  • Patent number: 10453667
    Abstract: A mass filter is disclosed having at least one electrode (42-48) comprising an aperture (43) or recess. Voltages are applied to the electrodes (42-48) of the mass filter such that ions having mass to charge ratios in a desired range are confined by the electrodes and are transmitted along and through the mass filter, whereas ions (47,49) having mass to charge ratios outside of said desired range are unstable and pass into the aperture (43) or recess such that they are filtered out by the mass filter. The aperture (43) or recess reduces or eliminates the number of ions that would otherwise impact the electrode surface facing the ion transmission axis and hence reduces degradation of the ion transmission properties of the mass filter.
    Type: Grant
    Filed: May 31, 2016
    Date of Patent: October 22, 2019
    Assignee: Micromass UK Limited
    Inventors: Martin Green, Jason Wildgoose, Keith Richardson, Kevin Giles, Daniel Kenny, David Langridge, Richard Moulds
  • Patent number: 10453666
    Abstract: RF ion guides are configured as an array of elongate electrodes arranged symmetrically about a central axis, to which RF voltages are applied. The RF electrodes include at least a portion of their length that is semi-transparent to electric fields. Auxiliary electrodes are then provided proximal to the RF electrodes distal to the ion guide axis, such that application of DC voltages to the auxiliary electrodes causes an auxiliary electric field to form between the auxiliary electrodes and the ion guide RF electrodes. A portion of this auxiliary electric field penetrates through the semi-transparent portions of the RF electrodes, such that the potentials within the ion guide are modified. The auxiliary electrode structures and voltages can be configured so that a potential gradient develops along the ion guide axis due to this field penetration, which provides an axial motive force for collision damped ions.
    Type: Grant
    Filed: July 23, 2018
    Date of Patent: October 22, 2019
    Assignee: PerkinElmer Health Sciences, Inc.
    Inventor: David G. Welkie
  • Patent number: 10444185
    Abstract: A reference value selection unit selects a reference value that lies in a predetermined margin from reference sample data corresponding to a set reference sample. A data acquisition unit acquires mass spectrum data in a data acquisition range including a set analysis range and the margin. A data correction unit corrects the mass spectrum data based on the reference value and a measured value on the reference sample in the data acquisition range. When no reference value lies in the margin, the reference value selection unit selects a reference value that lies outside the analysis range but closest to the margin. The data acquisition unit acquires mass spectrum data in a data acquisition range expanded to allow the reference value to lie in the data acquisition range. The data correction unit corrects the mass spectrum data based on the reference value and the measured value in the data acquisition range.
    Type: Grant
    Filed: April 11, 2016
    Date of Patent: October 15, 2019
    Assignee: SHIMADZU CORPORATION
    Inventors: Atsushige Ikeda, Tohru Shiohama
  • Patent number: 10446381
    Abstract: A method of introducing and ejecting ions from an ion entry/exit device (4) is disclosed. The ion entry/exit device (4) has at least two arrays of electrodes (20,22). The device is operated in a first mode wherein DC potentials are successively applied to successive electrodes of at least one of the electrode arrays ((20,22) in a first direction such that a potential barrier moves along the at least one array in the first direction and drives ions into and/or out of the device in the first direction. The device is also operated in a second mode, wherein DC potentials are successively applied to successive electrodes of at least one of the electrode arrays (20,22) in a second, different direction such that a potential barrier moves along the array in the second direction and drives ions into and/or out of the device in the second direction. The device provides a single, relatively simple device for manipulating ions in multiple directions.
    Type: Grant
    Filed: May 15, 2018
    Date of Patent: October 15, 2019
    Assignee: Micromass UK Limited
    Inventors: Kevin Giles, David J. Langridge, Jason Lee Wildgoose
  • Patent number: 10438787
    Abstract: The disclosure features mass spectrometry systems that include: an ion source; a module featuring an ion trap, an ion detector, and a module housing that at least partially surrounds the ion trap and the ion detector; and a vacuum pump featuring a housing having a recess dimensioned to receive the module, so that when the module is positioned within the recess of the vacuum pump housing, a portion of the module is surrounded by the vacuum pump housing, and during operation of the system, the ion source, ion trap, ion detector, and vacuum pump are connected along a common gas flow path and heat is transferred from the vacuum pump to the module.
    Type: Grant
    Filed: June 30, 2017
    Date of Patent: October 8, 2019
    Assignee: 908 Devices Inc.
    Inventors: Tony Liepert, Kevin McCallion, Christopher D. Brown, Kevin J. Knopp, Michael Jobin
  • Patent number: 10431442
    Abstract: A method of mass spectral analysis in an analytical electrostatic trap (14) is disclosed. The electrostatic trap (14) defines an electrostatic field volume and includes trap electrodes having static and non-ramped potentials. The method comprises injecting a continuous ion beam into the electrostatic field volume.
    Type: Grant
    Filed: August 7, 2017
    Date of Patent: October 1, 2019
    Assignee: LECO Corporation
    Inventor: Anatoly N. Verenchikov
  • Patent number: 10424475
    Abstract: A method of operating an electrostatic trapping mass analyzer, comprising: introducing a sample of ions into a trapping region of the mass analyzer, wherein a trapping field within the trapping region is such that the ions exhibit radial motion with respect to a central longitudinal axis of the trapping region while undergoing harmonic motion in a dimension defined by the central longitudinal axis, the frequency of harmonic motion of a particular ion being a function of its mass-to-charge ratio; superimposing a modulation field onto the trapping field within the trapping region, the modulation field acting to either increase or reduce the harmonic motion energies of the ions by an amount varying according to the frequency of harmonic motion; and acquiring a mass spectrum of the ions in the trapping region by measuring a signal representative of an image current induced by the harmonic motion of the ions.
    Type: Grant
    Filed: December 17, 2018
    Date of Patent: September 24, 2019
    Assignee: THERMO FINNIGAN LLC
    Inventors: Chad R. Weisbrod, Michael W. Senko, Jesse D. Canterbury, John E. P. Syka