Cyclically Varying Ion Selecting Field Means Patents (Class 250/290)
  • Patent number: 10804088
    Abstract: A mass spectrometry method comprises: generating ions; directing the ions through an ion optical component within a first chamber having a first vacuum pressure, the ion optical component maintained at a first electrical potential; transferring the ions through an ion guide within a second chamber having a second vacuum pressure less than the first vacuum pressure, the ion guide maintained at a second electrical potential, wherein a difference between the first and second potentials imparts kinetic energy that causes collision-induced ion fragmentation within the second chamber that removes adduct species; and transferring the ions into another ion guide within a third chamber having a third vacuum pressure less than the second vacuum pressure, the other ion guide maintained at a third electrical potential, wherein a difference between the third and second potentials reduces a portion of the imparted kinetic energy of the ions passing into the third chamber.
    Type: Grant
    Filed: May 30, 2019
    Date of Patent: October 13, 2020
    Assignee: Thermo Finnigan LLC
    Inventors: Michael P. Goodwin, Michael W. Senko, Graeme C. McAlister
  • Patent number: 10593534
    Abstract: An ion guide includes electrodes and an RF generator. The electrodes extend in a Z-axis that is straight or curved with a radius that is larger than a distance between the electrodes. The electrodes are made of carbon filled ceramic resistors, silicon carbide, or boron carbide to form bulk resistance with specific resistance between 1 and 1000 Ohm*cm. Conductive Z-edges are disposed on each electrode. An insulating coating is disposed on one side of each electrode and oriented away from an inner region of the ion guide surrounded by said electrodes. At least one conductive track per electrode is attached on a top side of the insulating coating. The conductive track is connected to one conductive electrode edge. The RF generator has at least two sets of secondary coils with DC supplies connected to central taps of the sets of secondary coils to provide at least four distinct signals.
    Type: Grant
    Filed: February 18, 2019
    Date of Patent: March 17, 2020
    Assignee: LECO Corporation
    Inventors: Anatoly N. Verenchikov, Viatcheslav Artaev
  • Patent number: 10573504
    Abstract: A multipole ion guide (30) including a plurality of rod electrodes arranged at an angle to the central axis (C) is placed within a collision cell (13) located in the previous stage of an orthogonal accelerator (16). Radio-frequency voltages with opposite phases are applied to the rod electrodes of the ion guide (30) so that any two rod electrodes neighboring each other in the circumferential direction have opposite phases of the voltage. A depth gradient of the pseudopotential is thereby formed from the entrance end toward the exit end within the space surrounded by the rod electrodes, and ions are accelerated by this gradient. During an ion-accumulating process, a direct voltage having the same polarity as the ions is applied to the exit lens electrode (132) to form a potential barrier for accumulating ions. Among the ions repelled by the potential barrier, ions having smaller m/z return closer to the entrance end.
    Type: Grant
    Filed: January 15, 2016
    Date of Patent: February 25, 2020
    Assignee: SHIMADZU CORPORATION
    Inventors: Osamu Furuhashi, Daisuke Okumura, Tomoyuki Oshiro
  • Patent number: 10422896
    Abstract: Improved, high count rate thermal neutron counters and electronics enabling new, higher measurement capabilities are disclosed. Next generation 3He and 10B tubes may include an electronics package capable of operating at higher count rates and in higher gamma fields and providing more efficient use of 3He gas. Conventional detector systems may also be upgraded, providing a possible solution to measure spent nuclear fuel with high neutron efficiency previously not possible in 235U fission counter systems. Switching the number of tubes per amplifier allows use of the measured nuclear material for a calibration standard for dead time correction, increasing accuracy of neutron measurements systems. An optimized detector geometry and advanced electronics with double pulse filtering and a dual channel readout may be provided. A bipolar shaper may improve dead time, provide efficient detector use, reduce double pulsing, facilitate high count rate measurements, and allow remote threshold setting.
    Type: Grant
    Filed: October 23, 2017
    Date of Patent: September 24, 2019
    Assignee: Triad National Security, LLC
    Inventors: Kiril Ianakiev, Metodi Iliev, Martyn Swinhoe, Michael Browne, Adrienne LaFleur
  • Patent number: 10424474
    Abstract: Methods and devices for ion separations or manipulations in gas phase are disclosed. The device includes a non-planar surface having a first, second and third region. An inner arrays of electrodes is positioned on the first region. A first set of electrodes of the inner array of electrodes is configured to receive RF voltages and generate a first potential upon the receipt of the RF voltage. A first and second outer arrays of electrodes are coupled to the second and third region, respectively. The first and second outer arrays are configured to receive a first DC voltage and generate a second potential upon the receipt of the first DC voltages. The first and second generated potential manipulate movement of ions.
    Type: Grant
    Filed: May 2, 2016
    Date of Patent: September 24, 2019
    Assignee: Battelle Memorial Institute
    Inventors: Yehia M. Ibrahim, Sandilya V. B. Garimella, Richard D. Smith
  • Patent number: 10408791
    Abstract: The invention relates to a method for operating an ion gate having at least a first, a second, and a third electrode, which are arranged one after the other in an intended drifting direction of ions to be influenced by the ion gate, in such a way that the second electrode is arranged after the first electrode and the third electrode is arranged after the second electrode in the drifting direction, wherein the ion gate can be switched between a closed state, in which ions cannot drift through the ion gate in the intended drifting direction, and an open state, in which ions can drift through the ion gate in the intended drifting direction, by applying potentials that alternate over time to one or more of the electrodes mentioned above, wherein, in a switching cycle of the ion gate, which comprises the open state and the closed state of the ion gate, two different closed states of the ion gate are produced in that, in a first closed state, the ion gate is closed by applying a first potential difference between t
    Type: Grant
    Filed: August 2, 2016
    Date of Patent: September 10, 2019
    Assignee: GOTTFRIED WILELM LEIBNIZ UNIVERSITAET HANNOVER
    Inventors: Stefan Zimmermann, Ansgar Kirk
  • Patent number: 10317364
    Abstract: Methods and apparatuses for ion manipulations, including ion trapping, transfer, and mobility separations, using traveling waves (TW) formed by continuous alternating current (AC) are disclosed. An apparatus for ion manipulation includes a surface to which are coupled a first plurality of continuous electrodes and a second plurality of segmented electrodes. The second plurality of segmented electrodes is arranged in longitudinal sets between or adjacent to the first plurality of electrodes. An RF voltage applied to adjacent electrodes of the first plurality of electrodes is phase shifted by approximately 180° to confine ions within the apparatus. An AC voltage waveform applied to adjacent electrodes within a longitudinal set of the second plurality of segmented electrodes is phase shifted on the adjacent electrodes by 1°-359° to move ions longitudinally through the apparatus for separation.
    Type: Grant
    Filed: August 15, 2016
    Date of Patent: June 11, 2019
    Assignee: Battelle Memorial Institute
    Inventors: Venkata B S Garimella, Ahmed M. Hamid, Yehia M. Ibrahim, Richard D. Smith
  • Patent number: 10203305
    Abstract: The tandem differential mobility spectrometer (DMS)-ion modulator instrument provides improved resolution relative to traditional DMS for molecules with larger masses. The instrument includes multiple ion-bunching electrodes, each with an AC field synchronized to the transit time of the ion flow which is positioned downstream of a DMS. The ion bunching electrodes produce each a mobility-dependent modulation of the ion current. The ratio of AC to DC current provides a measure of the mobility of a large ion, even if it has little differential mobility, thereby extending the useful range of mobility characterization of a DMS system. The instrument does not require high voltages or high frequencies. Modulation before DMS separation or between tandem DMS separations produces a variable range of analyte and reactant ion densities as well as spatially separating negative and positive ions to reduce ion recombination.
    Type: Grant
    Filed: July 26, 2017
    Date of Patent: February 12, 2019
    Inventors: David R. Hall, Dan Allen, Joe Fox
  • Patent number: 10134573
    Abstract: A voltage supply system for supplying an RF voltage to an RF resonant load comprising an ion-optical component of a mass spectrometer is disclosed. The system comprises a Direct Digital Synthesiser (“DDS”) arranged and adapted to output an RF voltage. The voltage supply system is arranged and adapted: (i) to vary the frequency of the RF voltage output by the Direct Digital Synthesiser, (ii) to determine a first resonant frequency of the RF resonant load comprising the ion-optical component, and (iii) to determine whether or not the generation of an RF voltage at the first resonant frequency by the Direct Digital Synthesiser would also result in the generation of a spur frequency close to the first resonant frequency.
    Type: Grant
    Filed: September 17, 2014
    Date of Patent: November 20, 2018
    Assignee: MICROMASS UK LIMITED
    Inventors: David Gordon, Richard Barrington Moulds, Kenneth Russell Worthington
  • Patent number: 10101335
    Abstract: Applications of ion-ion reaction chemistry are disclosed in which proton transfer reactions (PTR) combined with higher-collision-energy dissociation (HCD) are used to (1) simplify complex mixture analysis of samples introduced into a mass spectrometer, and (2) improve resolution and sensitivity for the analysis of large proteins in excess of 50 kDa by removing charge, reducing the collisional cross section, and, in several cases, enhancing the sequence coverage obtained.
    Type: Grant
    Filed: January 13, 2017
    Date of Patent: October 16, 2018
    Assignee: Thermo Finnigan LLC
    Inventors: William M. McGee, Helene L. Cardasis
  • Patent number: 9972483
    Abstract: A method of separating ions according to their time of flight is provided comprising: a. providing an analyzer comprising two opposing ion mirrors, each mirror comprising inner and outer field-defining electrode systems elongated along an analyzer axis with the outer field-defining electrode system surrounding the inner field-defining electrode system and creating therebetween an analyzer volume; b. injecting ions into the analyzer volume or creating ions within the analyzer volume so that they separate according to their time of flight as they travel along a main flight path while undergoing a plurality of axial oscillations in the direction of the analyzer axis and a plurality of radial oscillations while orbiting about one or more inner field-defining electrodes; c. the plurality of axial oscillations and plurality of radial oscillations causing the separated ions to intercept an exit port after a predetermined number of orbits.
    Type: Grant
    Filed: November 24, 2011
    Date of Patent: May 15, 2018
    Assignee: Thermo Fisher Scientific (Bremen) GmbH
    Inventor: Alexander A. Makarov
  • Patent number: 9966244
    Abstract: An ion manipulation method and device is disclosed. The device includes a pair of substantially parallel surfaces. An array of inner electrodes is contained within, and extends substantially along the length of, each parallel surface. The device includes a first outer array of electrodes and a second outer array of electrodes. Each outer array of electrodes is positioned on either side of the inner electrodes, and is contained within and extends substantially along the length of each parallel surface. A DC voltage is applied to the first and second outer array of electrodes. A RF voltage, with a superimposed electric field, is applied to the inner electrodes by applying the DC voltages to each electrode. Ions either move between the parallel surfaces within an ion confinement area or along paths in the direction of the electric field, or can be trapped in the ion confinement area.
    Type: Grant
    Filed: October 23, 2017
    Date of Patent: May 8, 2018
    Assignee: Battelle Memorial Institute
    Inventors: Gordon A. Anderson, Erin M. Baker, Richard D. Smith, Yehia M. Ibrahim
  • Patent number: 9953821
    Abstract: An ion guide system includes an ion guide with pole rods, a device for laterally introducing an ion species, and a mass spectrometer for analyzing product ions of reactions between different ion species. The device is configured and positioned such that an RF field with at least two-fold rotational symmetry with respect to the axis is generated. The device includes shortened pole rods and/or further electrodes. The pole rods and the further electrodes have at least two-fold rotational symmetry. The symmetry of the RF field allows ions to travel straight ahead through the ion guide with no hindrance. Such arrangements are particularly suitable for bringing together largely loss-free positive and negative ion species for reacting them. The reactions may be used to fragment multiply charged biopolymer ions by electron transfer or to remove excess charges of multiply charged biopolymer ions.
    Type: Grant
    Filed: April 25, 2017
    Date of Patent: April 24, 2018
    Assignee: Bruker Daltonik GmbH
    Inventor: Carsten Stoermer
  • Patent number: 9922812
    Abstract: An analyzer for separating ions according to their time of flight comprising two opposing ion mirrors abutting at a first plane, each mirror comprising inner and outer field-defining electrode systems elongated along an analyzer axis, the outer field-defining electrode system surrounding the inner field-defining electrode system. The outer field-defining electrode system of one mirror comprises two sections, the sections abutting at a second plane, comprising a first section between the first plane and the second plane, and a second section adjacent to the first section. The first section has at least a portion which extends radially from the analyzer axis a greater extent than an adjacent portion of the second section at the second plane. The outer field-defining electrode system comprises an exit port and the analyzer comprises a detector located downstream of the exit port.
    Type: Grant
    Filed: November 8, 2016
    Date of Patent: March 20, 2018
    Assignee: Thermo Fisher Scientific (Bremen) GmbH
    Inventor: Alexander Makarov
  • Patent number: 9899204
    Abstract: A method is described for the analysis of biological polymers, for example, intact proteins or oligonucleotides, by mass spectrometry. This method produces sample ions from a sample containing biological polymers, and ion species are selected that correspond to different charge states of a biological polymer molecule. The ion species are concurrently isolated from the sample ions to generate precursor ions in an ion trap mass spectrometer or in a quadrupole mass filter mass spectrometer. Precursor ions or product ions derived from the precursor ions may then be mass analyzed. The mass analysis step may include fragmenting the precursor ions to form product ions.
    Type: Grant
    Filed: June 3, 2016
    Date of Patent: February 20, 2018
    Assignee: Thermo Finnigan LLC
    Inventor: Aaron O. Bailey
  • Patent number: 9805920
    Abstract: A method of mass spectrometry is disclosed comprising automatically correcting the mass or mass to charge ratio resolution of a quadrupole mass filter or mass analyser one or more times during an experimental run or acquisition based upon a measurement, determination or estimation of the mass or mass to charge ratio resolution of one or more reference ions observed in a mass spectrum or mass spectral data acquired either during the same experimental run or acquisition or during a previous experimental run or acquisition.
    Type: Grant
    Filed: April 25, 2016
    Date of Patent: October 31, 2017
    Assignee: Micromass UK Limited
    Inventor: Daniel James Kenny
  • Patent number: 9734998
    Abstract: The present invention uses an AC voltage instead of DC voltage on an ion gate to filter/selectively pass ions. The ions that pass through the AC ion gate can be further separated in a spectrometric instrument. An ion mobility spectrometer using the AC ion gate can achieve better gating performance. For a time of flight ion mobility spectrometer with an AC ion gate, a narrow pulse of selected ions can be passed into a drift tube where they are separated based on their low field ion mobility. Moreover, when the AC voltage at the AC ion gate has a waveform as used for differential ion mobility spectrometry, the time of flight ion mobility spectrometer is converted into a two dimensional separation spectrometer, where ions are first separated based on their high field ion mobility and then further separated based on their low field ion mobility.
    Type: Grant
    Filed: January 11, 2016
    Date of Patent: August 15, 2017
    Assignee: Excellims Corporation
    Inventors: Ching Wu, Mark A Osgood
  • Patent number: 9726611
    Abstract: An ICP emission spectrometer is schematically configured to include an inductively coupled plasma generation unit, a light condensing unit, a spectroscope, a detector, and a controller. The detector includes a photomultiplier and has a detector controller and an input unit. The photomultiplier has voltage dividing resistors, which make an amplification factor not to become constant immediately due to a change in an application voltage applied to the photomultiplier, but the detector controller controls an idle voltage and an idle voltage application time so that a multiplication factor becomes constant, during a period from when analysis conditions are input to the input unit in advance until a sample containing an analysis-targeted element is introduced into the inductively coupled plasma generation unit.
    Type: Grant
    Filed: March 25, 2015
    Date of Patent: August 8, 2017
    Assignee: Hitachi High-Tech Science Corporation
    Inventor: Yoshitomo Nakagawa
  • Patent number: 9570279
    Abstract: A mass analyzer includes two rotating electric field (REF) units, sinusoidal signal generators and a means for separation of dispersed ions. The REF units include a plurality of elongated electrodes surrounding a central axis, and are lined in tandem at elongated direction. Sinusoidal signals are applied to the electrodes to rotate electric fields within each REF unit. The means for separation is placed adjacent the downstream end of the 2nd REF unit. Ions enter the 1st REF unit, diverge outwards and leave the 1st REF unit on off-axis positions. The ions successively enter the 2nd REF unit and converge inwards because of 180 degrees phase difference from the 1st REF unit. Specified mass ions return to and travel along the central axis. However, unspecified mass ions deviate from the central axis and travel apart from the central axis. The means for separation separates specified ions from unspecified ions.
    Type: Grant
    Filed: February 7, 2014
    Date of Patent: February 14, 2017
    Assignee: OFFICE TANDEM L.L.C.
    Inventors: Masanao Hotta, Tatsuya Adachi
  • Patent number: 9558925
    Abstract: A device for separating non-ions from ions is disclosed. The device includes a plurality of electrodes positioned around a center axis of the device and having apertures therein through which the ions are transmitted. An inner diameter of the apertures varies in length. At least a portion of the center axis between the electrodes is non-linear.
    Type: Grant
    Filed: April 18, 2014
    Date of Patent: January 31, 2017
    Assignee: Battelle Memorial Institute
    Inventors: Yehia M. Ibrahim, Richard D. Smith
  • Patent number: 9490115
    Abstract: Techniques are provided for scanning frequency and voltages of a multipole mass filter while maintaining substantially the same number of AC cycles per mass during a scan across a range of masses. For example, a mass spectrum can be obtained by controlling a DC axial voltage that accelerates ions into a mass filter, a DC resolving voltage applied to the mass filter, an AC voltage amplitude applied to the mass filter, and an AC frequency of the AC voltage. The settings can be controlled such that ions of different mass-to-charge ratios are within the mass filter for substantially a same number of AC cycles. To achieve the same number of AC cycles, the AC frequency is changed during the scan. For low masses, a higher AC frequency can be used. For high masses, a lower AC frequency can be used.
    Type: Grant
    Filed: December 18, 2014
    Date of Patent: November 8, 2016
    Assignee: Thermo Finnigan LLC
    Inventor: Johnathan W. Smith
  • Patent number: 9412578
    Abstract: A method of separating charged particles using an analyzer is provided, the method comprising: causing a beam of charged particles to fly through the analyzer and undergo within the analyzer at least one full oscillation in the direction of an analyzer axis (z) of the analyzer whilst orbiting about the axis (z) along a main flight path; constraining the arcuate divergence of the beam as it flies through the analyzer; and separating the charged particles according to their flight time. An analyzer for performing the method is also provided. At least one arcuate focusing lens is preferably used to constrain the divergence, which may comprise a pair of opposed electrodes located either side of the beam.
    Type: Grant
    Filed: January 31, 2014
    Date of Patent: August 9, 2016
    Assignee: Thermo Fisher Scientific (Bremen) GmbH
    Inventors: Alexander A. Makarov, Anastassios Giannakopulos
  • Patent number: 9412576
    Abstract: The present invention relates to an ion trap mass spectrometer using a cold electron source, in a production of a portable mass spectrometer, in which a microchannel plate (MCP) module is used, initial electrons are induced by injecting ultraviolet photons emitted from an ultraviolet diode to a front surface of the MCP module, electron beams amplified from the electrons are amplified using a channeltron electron multiplier (CEM), the amplified electron beams are accurately adjusted and injected into an ion trap, thus increasing the amplification rate, and since a quadrupole field is used as an ion filter which returns the initially injected electrons to the inside of an ion trap mass separator, the ionization rate increases.
    Type: Grant
    Filed: December 2, 2014
    Date of Patent: August 9, 2016
    Assignee: KOREA BASIC SCIENCE INSTITUTE
    Inventors: Seung Yong Kim, Mo Yang, Hyunsik Kim
  • Patent number: 9384953
    Abstract: A measurement condition memory stores a CID gas condition table indicating a relation between the scan speed of a mass scan by a front-stage quadrupole mass filter and a CID gas supply pressure. If the scan speed is high, an influence of a decrease in speed of ions due to collisions with a CID gas inside a collision cell is relatively large. An appropriate CID gas supply pressure that reduces the decay of a peak waveform on a mass spectrum and makes the ion intensity as high as possible is examined in advance for each scan speed, and is stored in advance. During measurement of a target sample, if a precursor ion scan measurement mode or the like is designated, a CID gas supply pressure corresponding to the currently set scan speed is obtained based on the CID gas condition table, and the CID gas supplier is controlled.
    Type: Grant
    Filed: November 13, 2012
    Date of Patent: July 5, 2016
    Assignee: SHIMADZU CORPORATION
    Inventor: Shinjiro Fujita
  • Patent number: 9330894
    Abstract: An ion transport device can include a plurality of pole rod pairs arranged in parallel, and a controller. The controller can be configured to apply voltages in a repeating voltage pattern to the pole rod pairs thereby creating a plurality of potential wells capable of capturing ions, and move the repeating voltage pattern along the pole rod pairs to move captured ions along the ion transport device. The ion transport device can be incorporated into a mass spectrometer.
    Type: Grant
    Filed: February 3, 2015
    Date of Patent: May 3, 2016
    Assignee: Thermo Finnigan LLC
    Inventor: Viatcheslav V. Kovtoun
  • Patent number: 9324550
    Abstract: The present disclosure is directed to an ion mobility drift tube fabricated using flex-circuit technology in which every other drift electrode is on a different layer of the flex-circuit and each drift electrode partially overlaps the adjacent electrodes on the other layer. This results in a self-shielding effect where the drift electrodes themselves shield the interior of the drift tube from unwanted electro-magnetic noise. In addition, this drift tube can be manufactured with an integral flex-heater for temperature control. This design will significantly improve the noise immunity, size, weight, and power requirements of hand-held ion mobility systems such as those used for explosive detection.
    Type: Grant
    Filed: February 5, 2015
    Date of Patent: April 26, 2016
    Assignee: Sandia Corporation
    Inventor: David Alexander Jones
  • Patent number: 9324543
    Abstract: A method of mass spectrometry is disclosed comprising automatically correcting the mass or mass to charge ratio resolution of a quadrupole mass filter or mass analyser one or more times during an experimental run or acquisition based upon a measurement, determination or estimation of the mass or mass to charge ratio resolution of one or more reference ions observed in a mass spectrum or mass spectral data acquired either during the same experimental run or acquisition or during a previous experimental run or acquisition.
    Type: Grant
    Filed: March 7, 2012
    Date of Patent: April 26, 2016
    Assignee: Micromass UK Limited
    Inventor: Daniel James Kenny
  • Patent number: 9214322
    Abstract: A detection system and a method for detecting ions which have been separated in a time-of-flight (TOF) mass analyzer, comprising an amplifying arrangement for converting ions into packets of secondary particles and amplifying the packets of secondary particles, wherein the amplifying arrangement is arranged so that each packet of secondary particles produces at least a first output and a second output separated in time and so that during the delay between producing the first and second output the first output produced by a packet of secondary particles is used for modulating the second output produced by the same packet. An increased dynamic range of detection and protection of the detection system against intense ion pulses is thereby provided.
    Type: Grant
    Filed: December 13, 2011
    Date of Patent: December 15, 2015
    Assignee: Thermo Fisher Scientific (Bremen) GmbH
    Inventors: Alexander Kholomeev, Alexander A. Makarov
  • Patent number: 9107581
    Abstract: The present invention relates to a device for determining mechanical, particularly elastic, parameters of an examination object, comprising a) at least one arrangement for determining the spatial distribution of magnetic particles in at least one examination area of the examination object, comprising a means for generating a magnetic field with a spatial profile of the magnetic field strength such that there is produced in at least one examination area a first part-area having a low magnetic field strength and a second part-area having a higher magnetic field strength, a means for detecting signals which depend on the magnetization in the examination object, particularly in the examination area, that is influenced by a spatial change in the particles, and a means for evaluating the signals so as to obtain information about the, in particular temporally changing, spatial distribution of the magnetic particles in the examination area; and b) at least one means for generating mechanical displacements, in particu
    Type: Grant
    Filed: April 15, 2004
    Date of Patent: August 18, 2015
    Assignee: Koninklijke Philips N.V.
    Inventors: Bernhard Gleich, Jürgen Weizenecker
  • Patent number: 9111741
    Abstract: The invention “Ion Trap Array (ITA)” pertains generally to the field of ion storage and analysis technologies, and particularly to the ion storing apparatus and mass spectrometry instruments which separate ions by its character such as mass-to-charge ratio. The aim of this invention is providing an apparatus for ion storage and analysis comprising at least two or more rows of parallel placed electrode array wherein each electrode array includes at least two or more parallel bar-shaped electrodes, by applying different phase of alternating current voltages on different bar electrodes to create alternating electric fields inside the space between two parallel electrodes of different rows of electrode arrays, multiple linear ion trapping fields paralleled constructed in the space between the different rows of electrode arrays which are open to adjacent each other without a real barrier.
    Type: Grant
    Filed: April 13, 2007
    Date of Patent: August 18, 2015
    Assignee: FUDAN UNIVERSITY
    Inventors: Chuanfan Ding, Li Ding
  • Patent number: 9070543
    Abstract: An ion mobility separator or spectrometer is disclosed comprising an inner cylinder and an outer cylinder defining an annular volume through which ions are transmitted. Spiral electrodes a-f are arranged on a surface of the inner cylinder and/or on a surface of the outer cylinder. A first device is arranged and adapted to maintain a DC electric field and/or a pseudo-potential force which acts to urge ions from a first end of the ion mobility separator or spectrometer to a second end of the ion mobility separator or spectrometer. A second device is arranged and adapted to apply transient DC voltages to the one or more spiral electrodes in order to urge ions towards the first end of the ion mobility separator or spectrometer. The net effect is to extend the effective path length of the ion mobility separator.
    Type: Grant
    Filed: September 8, 2014
    Date of Patent: June 30, 2015
    Assignee: Micromass UK Limited
    Inventors: Martin Raymond Green, David J. Langridge, Jason Lee Wildgoose
  • Patent number: 9064679
    Abstract: An ion spectrometer is provided, comprising: an ion source, arranged to generate ions continuously with a first range of mass to charge ratios; and an ion trap, arranged to receive ions from the ion source along an axis, and to eject ions with a second range of mass to charge ratios orthogonally to that axis, the second range of mass to charge ratios being narrower than the first range of mass to charge ratios. In some embodiments, ions generated by the ion source continuously flow into the ion trap. Additionally or alternatively, ion optics receive ions ejected from the ion trap and cool the ions without substantial fragmentation. An ion analyzer receives ions ejected from the ion trap or ion optics and separates the ions in accordance with at least one characteristic of the ions.
    Type: Grant
    Filed: November 26, 2012
    Date of Patent: June 23, 2015
    Assignee: Thermo Fisher Scientific (Bremen) GmbH
    Inventor: Alexander Alekseevich Makarov
  • Patent number: 9053918
    Abstract: A mass spectrometer is disclosed comprising a RF confinement device, a beam expander and a Time of Flight mass analyzer. The beam expander is arranged to expand an ion beam emerging from the RF confinement device so that the ion beam is expanded to a diameter of at least 3 mm in the orthogonal acceleration extraction region of the Time of Flight mass analyzer.
    Type: Grant
    Filed: August 11, 2014
    Date of Patent: June 9, 2015
    Assignee: Micromass UK Limited
    Inventors: Jeffery Mark Brown, Anthony James Gilbert, John Brian Hoyes, David J. Langridge, Jason Lee Wildgoose
  • Patent number: 9052284
    Abstract: The present invention discloses an asymmetric field ion mobility spectrometer. It comprises an ionization source, for generating ions; an electrode plate; a plurality of electrode filaments, arranged in opposite to and spaced apart from the electrode plate by an analysis gap, wherein a high voltage of electrical field is applied between the electrode plate and the electrode filaments to form an ion migration area, the electrode filaments used to collect the ions that do not pass through the ion migration area; and a collection electrode, disposed at a rear end of the ion migration area, and collecting the ions that have passed through the ion migration area. The present asymmetric field ion mobility spectrometer is capable of improving accuracy of identifying peak positions of the ions, reducing scanning time of DC voltage and types of compensation voltage, thereby increasing ion detection efficiency.
    Type: Grant
    Filed: December 28, 2012
    Date of Patent: June 9, 2015
    Assignee: Nuctech Company Limited
    Inventors: Shiping Cao, Qingjun Zhang, Zhiqiang Chen, Ziran Zhao, Yuanjing Li, Yinong Liu, Shuqiang Dong
  • Publication number: 20150144784
    Abstract: A novel scanning method of a mass spectrometer apparatus is introduced so as to relate by simple time shifts, rather than time dilations, the component signal (“peak”) from each ion even to an arbitrary reference signal produced by a desired homogeneous population of ions. Such a method and system, as introduced herein, is enabled in a novel fashion by scanning exponentially the RF and DC voltages on a quadrupole mass filter versus time while maintaining the RF and DC in constant proportion to each other. In such a novel mode of operation, ion intensity as a function of time is the convolution of a fixed peak shape response with the underlying (unknown) distribution of discrete mass-to-charge ratios (mass spectrum). As a result, the mass distribution can be reconstructed by deconvolution, producing a mass spectrum with enhanced sensitivity and mass resolving power.
    Type: Application
    Filed: December 9, 2014
    Publication date: May 28, 2015
    Inventor: Robert A. GROTHE, Jr.
  • Publication number: 20150144780
    Abstract: A method of mass spectrometry is disclosed comprising alternating between a first mode in which parent ions are mass analysed and a second mode in which the parent ions are subjected to Electron Capture Dissociation (“ECD”) at atmospheric pressure so as to produce fragment ions which are then mass analysed. The parent ions are associated with their fragment ions based on the times at which they were detected. This method enables parent ions to be associated with their fragment ions, even when the ECD fragmentation is performed at atmospheric pressure.
    Type: Application
    Filed: May 16, 2013
    Publication date: May 28, 2015
    Inventors: Jeffery Mark Brown, Martin Raymond Green, Steven Derek Pringle
  • Publication number: 20150115147
    Abstract: A drift tube ion mobility spectrometry sample introduction scheme allows introduction of a sample packet at ground voltages. The sample packet of ionized particles is captured by subjecting particles within a defined region to an electric field at an elevated voltage. The ionized particles in the captured packet then migrate through the drift tube down the voltage gradient according to their electrical mobility. The particles are directed to a high sensitivity detector, such as a condensation particle counter (CPC), for detection.
    Type: Application
    Filed: May 14, 2013
    Publication date: April 30, 2015
    Inventors: Derek Robert Oberreit, Christopher Joseph Hogan, Jr.
  • Publication number: 20150108348
    Abstract: The larger an m/z to be adjusted, the wider a peak width which represents change in intensity in relation to change in voltage. This allows voltage step size to be increased during a search for an optimum voltage without overlooking a maximum intensity. Thus, a relational expression which gives a narrow voltage step size for a low m/z and gives a wide voltage step size for a high m/z is prestored in a voltage step information storage unit (32), an optimum voltage adjustment controller (31) finds an optimum voltage step size for the m/z to be adjusted, during automatic voltage adjustment using the stored information, and controls a power supply unit 21 so as to change a voltage applied to a first ion guide (8) stepwise. Ion intensity obtained each time the applied voltage changes is determined, and a voltage value which gives a maximum ion intensity is found and stored in an optimum voltage information storage unit (33).
    Type: Application
    Filed: March 22, 2012
    Publication date: April 23, 2015
    Applicant: SHIMADZU CORPORATION
    Inventor: Kazuo Mukaibatake
  • Patent number: 9012840
    Abstract: A mass spectrometer is disclosed comprising a first quadrupole rod set mass filter, a collision cell, an ion mobility spectrometer or separator, an ion guide or collision cell arranged downstream of the ion mobility spectrometer or separator, a second quadrupole rod set mass filter and an ion detector.
    Type: Grant
    Filed: December 7, 2005
    Date of Patent: April 21, 2015
    Assignee: Micromass UK Limited
    Inventors: Robert Harold Bateman, Kevin Giles
  • Publication number: 20150102219
    Abstract: Prior to multiple reaction monitoring (MRM) measurement condition optimization, an analysis operator prepares, for each precursor ion of an objective compound, two lists on a product-ion selection condition setting screen 200, i.e. a list 203 which shows ions to be preferentially selected as product ions for which the optimization needs to be performed and a list 202 which shows ions to be excluded from the optimization. When a measurement is performed, a product-ion scan measurement for the precursor ion of the objective compound is performed and a spectrum is obtained. Among the ions extracted from this spectrum, any ion registered in the excludable-ion list 202 is excluded, while any ion registered in the preferred-ion list 203 is preferentially selected as a product ion. For each combination of the m/z values of the precursor ion and the product ions thus determined, optimum conditions of the MRM measurement are searched for.
    Type: Application
    Filed: October 7, 2014
    Publication date: April 16, 2015
    Applicant: SHIMADZU CORPORATION
    Inventor: Hideki YAMAMOTO
  • Patent number: 9006649
    Abstract: Mass spectrometers and methods for measuring information about samples using mass spectrometry are disclosed.
    Type: Grant
    Filed: December 31, 2012
    Date of Patent: April 14, 2015
    Assignee: 908 Devices Inc.
    Inventors: Andrew J. Bartfay-Szabo, Christopher D. Brown, Michael Jobin, Kevin J. Knopp, Evgeny Krylov, Scott Miller
  • Patent number: 9006647
    Abstract: A collision or fragmentation cell is disclosed comprising a plurality of electrodes wherein a first RF voltage is applied to an upstream group of electrodes and a second different RF voltage is applied to a downstream group of electrodes. The radial confinement of parent ions entering the collision or fragmentation cell is optimized by the first RF voltage applied to the upstream group of electrodes and the radial confinement of daughter or fragment ions produced within the collision or fragmentation cell is optimized by the second different RF voltage applied to the downstream group of electrodes.
    Type: Grant
    Filed: January 16, 2014
    Date of Patent: April 14, 2015
    Assignee: Micromass UK Limited
    Inventors: Daniel James Kenny, Robert Harold Bateman, Martin Raymond Green, Jason Lee Wildgoose, Steven Derek Pringle
  • Patent number: 9006650
    Abstract: Apparatus and methods for performing mass spectrometry of a nanoparticle or virus analyte. Apparatus may include a laser desorption plate, a mass analyzer configured to measure mass over the range of m/z from 105 to 1010, an electrical shield surrounding the mass analyzer, and a charge sensitive detector, wherein the laser firing is phase lock synchronized with the applied radiofrequency voltages.
    Type: Grant
    Filed: May 10, 2014
    Date of Patent: April 14, 2015
    Assignee: Academia Sinica
    Inventors: Chung-Hsuan Chen, Jung-Lee Lin, Huan Chang Lin
  • Patent number: 9000363
    Abstract: The present invention provides a radio frequency (RF) power supply in a mass spectrometer. The power supply provides an RF signal to electrodes of a storage device to create a trapping field. The RF field is usually collapsed prior to ion ejection. In an illustrative embodiment the RF power supply includes a RF signal supply; a coil arranged to receive the signal provided by the RF signal supply and to provide an output RF signal for supply to electrodes of an ion storage device; and a shunt including a switch operative to switch between a first open position and a second closed position in which the shunt shorts the coil output.
    Type: Grant
    Filed: November 7, 2013
    Date of Patent: April 7, 2015
    Assignee: Thermo Finnigan LLC
    Inventors: Alexander A. Makarov, Eduard V. Denisov, Alexander Kholomeev
  • Patent number: 8987661
    Abstract: A mass spectrometer is disclosed comprising a quadrupole rod set ion trap wherein a potential field is created at the exit of the ion trap which decreases with increasing radius in one radial direction. Ions within the on trap are mass selectively excited in a radial direction. Ions which have been excited in the radial direction experience a potential field which no longer confines the ions axially within the ion trap but which instead acts to extract the ions and hence causes the ions to be ejected axially from the ion trap.
    Type: Grant
    Filed: January 17, 2014
    Date of Patent: March 24, 2015
    Assignee: Micromass UK Limited
    Inventors: Martin Raymond Green, Daniel James Kenny, David J. Langridge, Jason Lee Wildgoose
  • Publication number: 20150076343
    Abstract: An ion manipulation method and device to prevent loss of ions is disclosed. The device includes a pair of surfaces. An inner array of electrodes is coupled to the surfaces. A RF voltage and a DC voltage are alternately applied to the inner array of electrodes. The applied RF voltage is alternately positive and negative so that immediately adjacent or nearest neighbor RF applied electrodes are supplied with RF signals that are approximately 180 degrees out of phase.
    Type: Application
    Filed: October 30, 2014
    Publication date: March 19, 2015
    Applicant: BATTELLE MEMORIAL INSTITUTE
    Inventors: Aleksey Tolmachev, Richard D. Smith, Yehia M. Ibrahim, Gordon A. Anderson, Erin M. Baker
  • Patent number: 8981287
    Abstract: The present invention is concerned with an ion analysis apparatus comprising an ion guide having an ion optical axis extending from an ion inlet to an ion outlet, the ion guide being configured to guide ions from the ion inlet to the ion outlet along the ion optical axis, wherein the ion guide comprises at least one extraction region located between the ion inlet and the ion outlet, the at least one extraction region being configured to extract ions moving along the ion optical axis of the ion guide in an extraction direction, the extraction direction being substantially orthogonal to the ion optical axis of the ion guide, wherein the apparatus includes ion radial confinement means that in use confine the ions in the radial direction within the ion guide.
    Type: Grant
    Filed: March 16, 2012
    Date of Patent: March 17, 2015
    Assignee: Shimadzu Corporation
    Inventors: Roger Giles, Matthew Clive Gill
  • Patent number: 8981290
    Abstract: Apparatus and methods are provided that enable the interaction of low energy electrons and positrons with sample ions to facilitate electron capture dissociation (EGO) and positron capture dissociation (PGO), respectively, within multipole ion guide structures.
    Type: Grant
    Filed: March 28, 2014
    Date of Patent: March 17, 2015
    Assignee: PerkinElmer Health Sciences, Inc.
    Inventors: Craig M. Whitehouse, David G. Welkie, Gholamreza Javahery, Lisa Cousins, Sergey Rakov
  • Patent number: 8975579
    Abstract: A mass spectrometer having a mass filter which applies a transient voltage profile to accelerate ion packets. The voltage profile is chosen to have a functional form which imparts each ion species with a kinetic energy which is larger the larger the mass-to-charge ratio and a velocity which is smaller the larger the mass-to-charge ratio. The ions are detected in an ion detector which discriminates between different ion species based on their kinetic energy and taking account of the functional form of the voltage profile. Suitable voltage profiles include periodic functions such as sinusoids, triangles and sawtooths, which allow the amplification of drive pulses in the mass filter to be carried out with narrow band amplification stages, which are simple and inexpensive to construct.
    Type: Grant
    Filed: March 2, 2011
    Date of Patent: March 10, 2015
    Assignee: Ilika Technologies Limited
    Inventors: David Bream, Christopher Newman, Brian Christopher Webb
  • Patent number: 8975578
    Abstract: A linear ion trap is disclosed wherein an asymmetric voltage waveform is applied to electrodes forming the ion trap which causes ions to become radially separated according to their differential ion mobility. An axial potential barrier is arranged at the exit of the ion trap such that ions having a first differential ion mobility and a first radial displacement are retained axially within the ion trap but ions having a second differential ion mobility and a second radial displacement are ejected axially from the ion trap.
    Type: Grant
    Filed: October 26, 2011
    Date of Patent: March 10, 2015
    Assignee: Micromass UK Limited
    Inventors: Martin Raymond Green, Kevin Giles, David J. Langridge