Abstract: A sensor is proposed for authenticity identification of luminescent identification features on documents, in which the identification feature is illuminated with an excitation wavelength and may respond at a different wavelength, with the response wavelength being detected and evaluated by a radiation receiver. The focused beam emitted from a beam source is converted by focusing optics in such a manner that a scanning line, which is approximately in the form of a bar, is projected on the surface of the document to be investigated, which causes the signet, which is arranged on the document, to fluoresce at least in one subregion, and the fluorescence signal produced in this way is passed via detection objects to an evaluation unit, which evaluates the fluorescence signal.

Abstract: A new hand-held spectrophotometer-based is provided for identifying and discriminating the presence of labels which provide a characteristic emission spectrum upon illumination and further include algorithms for the analysis of data from a collected spectrum and comparing it against previously stored data to determine whether there is a match.

Abstract: An air shower head of an exposure device of photolithography equipment is free of chemical substances that could otherwise contaminate a photoresist layer on a semiconductor wafer and degrade the profile of the photoresist pattern. The air shower head is interposed between a lens system of the exposure device and a wafer stage, and has a hole in the middle thereof through which exposure light can pass to a wafer supported on the stage. The air shower head includes an upper frame defining a cavity open at the bottom thereof, and a porous bottom member covering the bottom of the upper frame. The porous member is mechanically secured to bottom ends of both the inner and outer side walls of the upper frame, i.e., without the use of chemical binders, to reduce the ability of the air shower head to serve as a source of contamination.

Abstract: A method and apparatus for determining the fluorescence, luminescence, or absorption of a sample is provided. The sample may either be contained within a cuvette or within one or more sample wells within a multi-assay plate. A combination of a broadband source, a monochromator, and a series of optical filters are used to tune the excitation wavelength to a predetermined value within a relatively wide wavelength band. A similar optical configuration is used to tune the detection wavelength. An optical scanning head assembly is used that includes mirrored optics for coupling the excitation source to the sample and the emitted light to the detector. An elliptical focussing mirror is used to magnify and focus the light projected from an optical fiber coupled to the source subassembly onto the sample. A portion of the source light is reflected by a beamsplitter onto a reference detector used to monitor the output of the source.

Abstract: A method and apparatus for determining the fluorescence, luminescence, or absorption of a sample is provided. The sample may either be contained within a cuvette or within one or more sample wells within a multi-assay plate. A combination of a broadband source, a monochromator, and a series of optical filters are used to tune the excitation wavelength to a predetermined value within a relatively wide wavelength band. A similar optical configuration is used to tune the detection wavelength. In one aspect, multiple optical fibers are coupled to the excitation source subassembly, thus allowing the system to be quickly converted from one optical configuration to another. In another aspect, the excitation light and the detected sample emissions pass to and from an optical head assembly via a pair of optical fibers. The optical head assembly is scanned across one axis of the sample multi-assy plate.

Abstract: An ultraviolet (UV) catadioptric imaging system, with broad spectrum correction of primary and residual, longitudinal and lateral, chromatic aberrations for wavelengths extending into the deep UV (as short as about 0.16 &mgr;m), comprises a focusing lens group with multiple lens elements that provide high levels of correction of both image aberrations and chromatic variation of aberrations over a selected wavelength band, a field lens group formed from lens elements with at least two different refractive materials, such as silica and a fluoride glass, and a catadioptric group including a concave reflective surface providing most of the focusing power of the system and a thick lens providing primary color correction in combination with the focusing lens group. The field lens group is located near the intermediate image provided by the focusing lens group and functions to correct the residual chromatic aberrations. The system is characterized by a high numerical aperture (typ. greater than 0.

Abstract: Miniaturized UV detection apparatus is disclosed comprising a low voltage UV bulb and detector. Bulb and detector are arranged in juxtaposition with their optical axes essentially parallel. Optical means are provided to focus the light from the bulb onto, for example, a forged banknote (bill). The paper onto which most banknotes are printed does not fluoresce under TV light but that commonly used by forgers does. If the note fluoresces, it is probably a forgery and the flouresced light is focused by the optical means onto the detector causing an output signal to be generated and passed to discriminating circuitry which operates means to accept genuine notes and reject forgeries, according to the magnitude of the signal. The PCB on which the components are mounted also acts as a screen between bulb and detector to stop light from the bulb reaching the detector. The components are located in a sleeve and are protected by insulating and thermally conducting potting compounds.

Abstract: A system and method is disclosed for chromatography and electrophoresis using circular optical scanning. One or more rectangular microchannel plates or radial microchannel plates has a set of analysis channels for insertion of molecular samples. One or more scanning devices repeatedly pass over the analysis channels in one direction at a predetermined rotational velocity and with a predetermined rotational radius. The rotational radius may be dynamically varied so as to monitor the molecular sample at various positions along a analysis channel. Sample loading robots may also be used to input molecular samples into the analysis channels. Radial microchannel plates are built from a substrate whose analysis channels are disposed at a non-parallel angle with respect to each other. A first step in the method accesses either a rectangular or radial microchannel plate, having a set of analysis channels, and second step passes a scanning device repeatedly in one direction over the analysis channels.

Abstract: The apparatus has an illuminating device for illuminating sheet material with clocked excitation light. Both during the light phase of clocked excitation light and during the dark phase of clocked excitation light a sensor detects an intensity of the light emitted by the sheet material in each case. In an evaluation device an intensity of fluorescently emitted light and an intensity of phosphorescently emitted light are derived from the intensities detected in the light phase and in the dark phase of clocked excitation light. In order to ensure long preillumination with high intensity, the sensor preferably detects the intensities of emitted light within, and toward the end (in the transport direction) of, the area of the sheet material illuminated by the illuminating device. Additionally the illuminated area of the sheet material is selected to be so great that it is a multiple of the desired resolution.

Abstract: A process and apparatus for monitoring the cleaning of a surface (1) by laser irradiation includes illuminating the surface (1) to be cleaned, being cleaned or having been cleaned by ultra-violet irradiation provided either by the cleaning laser or by a further source (5) sufficient to excite into fluorescence contaminants (10, 11) on the surface (1) which fluoresce under ultra-violet irradiation.

Abstract: The present invention relates to the exploration for and exploitation of formation hydrocarbons. According to the invention, a sample of material, representative of the impregnation with hydrocarbons of the rocks passed through, is taken during a drilling operation, with which sample a value of an emission flux, representative of the concentration of the fluorescent elements in the sample, and a value of a fluorescence quotient, which reflects the nature of the hydrocarbons present in the sample, are determined by spectrofluorimetry. The invention finds its application in analytical laboratories and on the drilling sites of petroleum production fields.

Abstract: A hand held, self-contained, automatic, low power and rapid sensor platform for detecting and quantifying a plurality of analytes. A sample solution potentially containing an unknown amount of an analyte is passed through an affinity column which contains antibodies to which the analyte binds thereby extracting the analyte. The affinity column is then rinsed to remove any other chemicals that may fluoresce. The rinsed affinity column is then eluted with a known volume of elution fluid causing the analyte to release from the antibody and dissolve in the fluid (eluant). The eluant is then placed in the quartz cuvette of a fluorometer. The analyte suspended in the eluant fluoresces at a waveband which is different than that of the light source that excites it. The amount of fluorescence is measured and the level of analyte determined.

Abstract: An optical apparatus, especially a scanning microscope (1), wherein an expanded laser beam (2) is divided into several partial beams (4) by micro lenses (5) arranged next to one another. Each partial beam (4) is focused onto a focal point (11) by a common objective lens (7) to optically excite a sample (8). Fluorescent light emanating from the individual focal points (11) of the sample (8) is registered by a photo sensor (13) arranged behind the objective lens (7) as seen from the sample (8). Each photon of the fluorescent light coming from the sample (8) and being registered by the photo sensor (13) is excited by at least two photons of the laser beam (2).

Abstract: In scanned optical systems such as confocal laser microscopes wherein a beam of light is focused to a spot in a specimen to excite a fluorescent species or other excitable species in the spot, the effective size of the excitation is made smaller than the size of the spot by providing a beam of light of wavelength adapted to quench the excitation of the excitable species, shaping this second beam into a pattern with a central intensity minimum, and overlapping this central minimum with the central intensity maximum of the focused spot, so that within the spot the intensity of quenching light increases with distance from the center of the spot, thereby preferentially quenching excitation in the peripheral parts of the spot, and thereby reducing the effective size of the excitation and thus improving the resolution of the system.

Abstract: A new class of ultraviolet dosimeters is made possible by exposing caged dye molecules, which generate a dye molecule on exposure to ultraviolet radiation, to an exterior environment. Applications include sunburn monitors, characterizing the UV exposure history of UV-sensitive materials, especially including structural plastics, and use in disposable ‘one-use’ optical equipment, especially medical devices.

Abstract: A method and apparatus for detection of a particular material, such as photo-resist material, on a sample surface. A narrow beam of light is projected onto the sample surface and the fluoresced and/or reflected light intensity at a particular wavelength band is measured by a light detector. The light intensity is converted to a numerical value and transmitted electronically to a logic circuit which determines the proper disposition of the sample. The logic circuit controls a sample-handling robotic device which sequentially transfers samples to and from a stage for testing and subsequent disposition. The method is particularly useful for detecting photo-resist material on the surface of a semiconductor wafer.

Abstract: A fluorescence cube comprising a housing; an exciter filter which allows passage of an incident light comprising a spectral range of from about 200 nanometers to about 400 nanometers; and either a beam splitter or a dichroic mirror which directs the incident light in a desired direction, and which transmits an emitted light in a desired direction. Also disclosed is a method of using the fluorescence cube for acquiring multicolor fluorescence images, the method comprising fluorescence labeling of a substrate with more than one species of water-soluble nanocrystals; and imaging the labeled substrate with a detection system comprising the fluorescence cube by exposing the labeled substrate to an incident light comprising an excitation spectral range, and detecting a transmitted light comprising an emission spectral range.

Abstract: The present invention provides, a 3 or 4-amino-1,8-naphthalimide compound having polyether substituent groups at the 3 or 4-position and the imide position. The polyether groups are linked to a hydrocarbon directly linked at the 3 or 4-amino position and the imide position. The polyether groups render the 3 or 4-amino-1,8-naphthalimide compound sufficiently soluble in a fluid such that visualization of the fluid by color or fluoresence is allowed. In one advantageous embodiment, the 3 or 4-amino-1,8-naphthalimide is obtained from the mixture of 4-chloro-1,8-naphthalic anhydride with monoamine polyether.

Abstract: A method and apparatus for imaging a sample are provided. An electromagnetic radiation source generates excitation radiation which is sized by excitation optics to a line. The line is directed at a sample resting on a support and excites a plurality of regions on the sample. Collection optics collect response radiation reflected from the sample I and image the reflected radiation. A detector senses the reflected radiation and is positioned to permit discrimination between radiation reflected from a certain focal plane in the sample and certain other planes within the sample.

Abstract: A method and apparatus for measuring the thickness of a coating on a coated surface. The method uses a solid state array of light-sensitive elements to measure light emitted from a fluorescing coating composition. The intensity of the emitted light corresponds to the thickness of the coating composition, and provides a fast and accurate measure of coating thickness.

Abstract: A system for determining the presence and optionally the position of an ophthalmic product such as a contact lens in a container.

Abstract: This invention relates to a fluorescence-based immunoassay method for the detection of an analyte, or for the measurement of its concentration in a biological sample. The method is based on the ability of a multivalent analyte to induce aggregation of receptor molecules labeled with a fluorophore, which molecules are anchored to and are freely mobile on a lipid membrane, and thereby cause changes in the fluorescence.

Abstract: A glucose monitor, and related method, determines the concentration of glucose in a sample with water, using a predictive regression model. The glucose monitor illuminates the sample with ultraviolet excitation light that induces the water and any glucose present in the sample to emit return light that includes raman scattered light and glucose emission or fluorescence light. The return light is monitored and processed using a predictive regression model to determine the concentration of glucose in the sample. The predictive regression model accounts for nonlinearities between the glucose concentration and intensity of return light within different wavelength bands at a predetermined excitation light energy or the intensity of return light within a predetermined wavelength band at different excitation energy levels. A fiber-optic waveguide is used to guide the excitation light from a laser excitation source to the sample and the return light from the sample to a sensor.

Abstract: A micro-circuit for performing analyses of multimolecular interactions and for performing molecular syntheses, comprising: (a) a support; (b) at least one micro-electrode attached to the support, the micro-electrode being selectively electronically activated and the micro-electrode having a protective layer which is removable; (c) a binding entity for attachment to the at least one micro-electrode, the binding entity being capable of attachment to at least one micro-electrode when the protective layer has been removed; and (d) a power source being operatively connected to at least one micro-electrode for electronically activating at least one micro-electrode. The micro-circuit of the present invention also includes embodiments featuring a micro-circuit reader for detecting the interaction of the binding entity to a complementary probe, as well as methods for making and using the micro-circuit of the present invention.

Abstract: A device for increasing the visibility of bicyclists and others “at risk” at night and during other low visibility conditions, and the chemical method of producing the same, wherein the device is a luminescent, planar portion of material manufactured using a mixture of PVC, phosphorescent, brightener, and fluorescent color that results in bonding of the phosphorescent and fluorescent ingredients. The luminescent portion provides continuous, visible light emission in the dark and at other times of low visibility, given intermittent exposure to an external light source. A fastener for attaching the luminescent material to the spokes of a bicycle wheel is also provided. An anchor pin projecting through the luminescent portion has a slotted end for receiving the spoke of a bicycle wheel. A lock washer fits over the tapered end of the anchor pin and retains the spoke between the closed end of the slot and a flange.

Abstract: An apparatus for storing and disinfecting a fluid includes a container (12) and a cap member (16) for containing the fluid and a cap member (16). The container (12) defines an opening (14) through which the fluid is dispensed therein and is removed therefrom and has at least two electrical contacts which mate with at least two electrical contacts in the cap member. The cap member (16) removably seals the opening of the container (12). An ultraviolet source (24) is mounted to at least one of the container (12) and the cap member (16). The ultraviolet source (24) emits ultraviolet radiation to disinfect the fluid contained in the container (12). A power source is electrically coupled to the at least two electrical contacts of the container (12).

Abstract: A lamp system is for use in non-destructive testing to illuminate luminescent materials, such as fluorescent dyes. The lamp system has a control unit and a lamp. The lamp has a bulb and a filter. The bulb generates at least a first wavelength of invisible energy and the filter limits other visible wavelength light from the lamp. The lamp has a handle with a trigger. The control unit pulses the lamp on and off when the trigger is depressed. The lumiescent material absorbs the first wavelength of energy and pulses in response when the lamp illuminates the material. The system can be AC or DC operated. It can be operated from an automotive battery. A fault locating system for use with fluorescent dyes to detect faults in a body has a handheld D-type battery flashlight configuration with a casing having a handle at one end and a flared lamp housing at the other. A reflector fits within the lamp housing, and a bulb rests in the reflector.

Abstract: Multi-photon excitation fluorescence microscopy is carried out by focusing an excitation beam by an objective lens onto a specimen and collecting the multi-photon fluorescence light emitted from the specimen to the objective lens and directing the fluorescent light on an optical path to a detector. Fluorescent light emissions from the specimen collected by a condenser lens on the opposite side of the specimen from the objective lens are directed to a dichoic mirror, which reflects the light photons back into the condenser lens and thence into and through the objective lens where they are directed on an optical path to the detector. Significantly increased fluorescent photon collection efficiency is obtained as well as improved image intensity of the detected fluorescent light.