Abstract: A method and apparatus for producing nanometer-sized particles, the method including the steps of forming of mixture by mixing a first precursor reactant, a second precursor reactant, a surface-stabilizing surfactant, and a high boiling point liquid to form a mixture, forming a mist of droplets of the mixture, heating the droplets to cause a reaction between species of the first and second precursor reactants within the heated droplets, and collecting the nanometer-sized products.

Abstract: Apparatus for the granulation of a predetermined substance provided in fluid, semi-fluid and similar state, comprising a prilling tower.

Abstract: Provided is an aerosol method, and accompanying apparatus, for preparing powdered products of a variety of materials involving the use of an ultrasonic aerosol generator (106) including a plurality of ultrasonic transducers (120) underlying and ultrasonically energizing a reservoir of liquid feed (102) which forms droplets of the aerosol. Carrier gas (104) is delivered to different portions of the reservoir by a plurality of gas delivery ports (136) delivering gas from a gas delivery system. The aerosol is pyrolyzed to form particles, which are then cooled and collected. The invention also provides powders made by the method and devices made using the powders.

Abstract: Metal-carbon composite powders and methods for producing metal-carbon composite powders. The powders have a well-controlled microstructure and morphology and preferably have a small average particle size. The method includes forming the particles from an aerosol of powder precursors. The invention also includes novel devices and products formed from the composite powders.

Abstract: Method for preparing a target substance in particulate form, comprising introducing into a particle formation vessel, through separate first and second fluid inlets respectively, (a) a “target solution/suspension” of the substance in a fluid vehicle and (b) a compressed fluid anti-solvent, and allowing the anti-solvent to extract the vehicle so as to form particles of the substance, wherein the anti-solvent fluid has a sonic, near-sonic or supersonic velocity as it enters the vessel, and wherein the anti-solvent and the target solution/suspension enter the vessel at different locations and meet downstream (in the direction of anti-solvent flow) of the second fluid inlet. Also provided is apparatus for use in such a method.

Abstract: Provided is an aerosol method, and accompanying apparatus, for preparing powdered products of a variety of materials involving the use of an ultrasonic aerosol generator (106) including a plurality of ultrasonic transducers (120) underlying and ultrasonically energizing a reservoir of liquid feed (102) which forms droplets of the aerosol. Carrier gas (104) is delivered to different portions of the reservoir by a plurality of gas delivery ports (136) delivering gas from a gas delivery system. The aerosol is pyrolyzed to form particles, which are then cooled and collected. The invention also provides powders that include particles made by the method and devices made using the particles.

Abstract: A method and an apparatus for continuously producing particles from an emulsion by supercritical fluid extraction. The emulsion includes a solute suspended or dissolved in the supercritical fluid soluble first phase. The supercritical fluid and the emulsion contact each other such that the first phase dissolves from the emulsion into the supercritical fluid and the solute precipitates to form a suspension in a non supercritical fluid soluble second phase of the emulsion. The supercritical fluid carries away the dissolved first phase. The solvent bearing supercritical fluid, together with the solute suspended in the second phase, is removed from an extraction chamber at a rate that is about the same as a rate that the emulsion and the supercritical fluid flow into the extraction chamber. Thus, a constant mass and pressure is maintained in the extraction chamber and the particles are produced continuously.

Abstract: A crucible is formed of a cylindrical body member and a disk-shaped nozzle member fitted to the bottom portion of the body member, and the nozzle member is provided with a nozzle hole for discharging out a semiconductor molten solution dropwise therethrough. The semiconductor molten solution drops discharged out of the crucible through the nozzle hole are cooled and solidified during falling to become semiconductor grains. Silicon grains having high crystal quality can be manufactured at low cost.

Abstract: A method for forming polymer microspheres includes dispensing polymeric material from an orifice of a drop-on-demand ink jet printhead while the orifice is immersed in a solvent extraction media.

Abstract: A binder B for inorganic powders comprises a mixture of b1 from 80 to 99.5% by weight of a polyoxymethlene homopolymer or copolymer B1 and b2 from 0.5 to 20% by weight of a polymer system B2 which is not miscible with B1 and comprises b21 from 5 to 100% by weight of polytetrahydrofuran B21 and b22 from 0 to 95% by weight of at least one polymer B22 of C2-8-olefins, vinylaromatic monomers, vinyl esters of aliphatic C1-8-carboxylic acids, vinyl C1-8-alkyl ethers or C1-12-alkyl (meth)acrylates.

Abstract: Processes for preparing surfactant granules, wherein the processes comprise: (a) passing a water-containing surfactant preparation through a casting plate, wherein the casting plate vibrates, such that droplets of the preparation are formed; and (b) contacting the droplets with a gaseous drying agent; are described.

Abstract: Among the conventional processes for producing solid dispersion, the solid dispersion obtained by a solvent method is excellent in terms of solubility and bioavailability of a poorly soluble drug. However, due to frequent uses of organic solvents in the solvent method, problems have arisen such as organic solvent residue in products, environmental pollution and operational safety as well as corporate problems such as capital investment and the like required to avoid such events. The present invention provides a process for preparing pharmaceutical solid preparations without use of organic solvents frequently used in conventional solvent methods.

Abstract: The invention relates to a process and an apparatus for forming molten drops of precursors of thermoplastic polyesters or copolyesters as molten monomer, oligomer, monomer/glycol mixture or after partial polycondensator [sic] and melting to give a molten precursor, in which the precursor formed into drops is introduced into a gaseous medium, and the gaseous medium, after entry of the precursor formed into drops into the gaseous medium, accelerates the crystallization process by holding the drop-form precursor at a temperature above 100° C. and below its melting point for a limited time until crystallization of the drop at the surface of the precursor is complete. To this end, the apparatus has a fall tower, through which the gaseous medium flows in countercurrent from bottom to top, while the drops fall in the vertical direction from top to bottom into a collecting funnel with a precrystallized surface.

Abstract: Metal-carbon composite powders and methods for producing metal-carbon composite powders. The powders have a well-controlled microstructure and morphology and preferably have a small average particle size. The method includes forming the particles from an aerosol of powder precursors. The invention also includes novel devices and products formed from the composite powders.

Abstract: A process for producing inorganic spheres, which comprises injecting an aqueous liquid containing an inorganic compound into a laminar flow of an organic liquid which runs at a flow rate of from 0.001 to 2 m/s in a flow path through a porous membrane to form a W/O type emulsion and solidifying the aqueous liquid containing an inorganic compound in the W/O type emulsion.

Abstract: A process, and a suitable apparatus, for production of particles of a material in which stream of a dispersion of the material in a solvent and a stream of a compressible fluid antisolvent substance are mixed under conditions such that the substance is in compressible fluid antisolvent state. The mixture then flows along a conduit (17) toward an orifice (18), from which it flows into a downstream region in which the compressible fluid antisolvent substance decompresses and the material is isolated in a particulate state. Preferably the antisolvent substance is a supercritical fluid. The process and apparatus can generate a co-formulation of the material with additives which can be introduced in a suitable aqueous or solvent based carrier vehicle.

Abstract: A method of forming substantially spherical ceramic beads that includes conveying an aqueous ceramic slurry to a nozzle tip that is immersed in an inert water-immiscible fluid layer. The nozzle tip is spaced a predetermined distance away from a rotating disk that is also immersed in the immiscible fluid layer. The rotating disk creates a shear force that at the nozzle tip that dislodges droplets of the aqueous ceramic slurry from the nozzle tip into the immiscible fluid layer. Once dislodged, the droplets assume a substantially spherical shape and a substantially mono-modal size distribution. The droplets are permitted to pass from the immiscible fluid layer into an aqueous gelling solution wherein the droplets are converted into rigid beads. In a preferred embodiment of the invention, the rigid beads are recovered from the gelling solution, washed, and then sintered to obtain a density of greater than about 98% of theoretical density and a sphericity of greater than about 0.95.

Abstract: A method and apparatus to process a diverted molten polymer waste stream directs the polymer stream to one of at least two passages, separates it into individual segments while containing and discharging it from a containment exit, cools each segment with a quench fluid to form a solid or semi-solid polymer, and transports the solidified segments away from the exit and into a container using the quench fluid. The apparatus includes a cross-section transition connector, a moveable block with two passages, a block oscillator, a cut-off plate, and open space above an inclined transporting device, a quench fluid jet, and a quench fluid transporting trough.

Abstract: A method of making a spherical seamless capsule formed by encapsulating a filler material such as a medicine with a capsule shell material shell such as gelatin. A liquid capsule shell material is stored in a tank at a low temperature, and supplied to a concentric multiple nozzle while it temperature is raised to a predetermined temperature upon being gradually heated while being transferred to the concentric multiple nozzle. This prevents deterioration in the capsule shell material and excessive decrease in its viscosity. When the liquid filler material and the capsule shell material flow out of the concentric multiple nozzle, their flows are cut by imparting a vibration thereto, to form a droplet in which the filler material and the capsule shell material are disposed at the center and on the outside, respectively. Such droplets are dropped into a curing liquid while in a dispersed state to cure the surface of the capsule shell material.

Abstract: An apparatus and a method for manufacturing granules includes a spray nozzle disposed within a granulating chamber of an apparatus body. The spray nozzle feeds by spraying into the granulating chamber a liquid material comprising at least one of mixture having solid and liquid in a mixed state and solution including solid dissolved therein. An air blowoff portion is provided at a lower region of the granulating chamber for feeding air for floating and fluidizing the liquid material and fine particles under granulation inside the granulating chamber. An air exhaust port is provided at an upper region of the granulating chamber for exhausting the air present inside the granulating chamber. The spray nozzle is designed to spray the liquid material upwardly.

Abstract: A plastic particle is formed of a plastic material having at least one integral protruding ring disposed on its outer surface. The ring may be continuous or intermittent around a perimeter of the plastic particle. Preferably, the particles have an outer diameter in the range of 0.007 inches to 0.040 inches.

Abstract: A method and an apparatus are provided for efficiently manufacturing microspheres having a uniform particle diameter. The apparatus comprises: case 1 having a lower body 1a and an upper body 1b. A seal ring 3, a first plate 4 which is comprised of a transparent plate such as a glass plate or a plastic plate, an annular spacer 5, an intermediate plate 6 which is comprised of a silicon substrate or the like, an annular spacer 7, a second plate 8 and a seal ring 9 are inserted in this order into a concave portion 2 formed in the lower body 1a. The upper body 1b is superposed thereon. Further, the upper body 1b is attached to the lower body 1a with bolts or the like.

Abstract: The invention relates to the formulation of deltamethrin as water-dispersible granules which comprise wetting agents, dispersants, solid inert substances and one or more acids in an amount sufficient to adjust the pH of the mixture to a value in the range from 1 to 7. The granules are particularly useful for controlling animal pests.

Abstract: Provided are a cosmetic particle having a silky feel, a method of producing the cosmetic particle at a low cost and a cosmetic containing the particle. The present invention resides in a method of producing a cosmetic particle having a hardness of 4 or less, the method comprising heating a base material containing wax at a temperature greater than or equal to the melting point of the base material and spraying the base material into a vapor phase at a temperature at which the viscosity of the base material is 600 mPa•s or less, the method of producing a cosmetic particle wherein the base material further contains a silicone compound, a cosmetic particle obtained by these production methods and a cosmetic containing the cosmetic particle.

Abstract: The present invention relates to a process for the production of particles from solutions or melts of heat-activatable polyurethanes by i) dissolving a compressible auxiliary agent at a pressure of between 50 and 1000 bar into a conveyable solution or melt of a heat-activatable polyurethane to obtain a mixture of polyurethane, compressible auxiliary agent and optionally solvent, ii) optionally adjusting of the temperature of the resulting mixture to a temperature of from 40° K below to 150° K above the crystallite melting point of the polyurethane, iii) expanding the mixture by means of an expansion device into a container, while adjusting the temperature in the container to at least 5° K below the softening temperature of the polyurethane to maintain the open jet particles in a form in which they do not agglomerate, and iv) separating the formed particles from the stream of decompressed compressible auxiliary agent and optionally solvent.

Abstract: Method for making polymer particulates, such as spherical powder and whiskers, by melting a polymer material under conditions to avoid thermal degradation of the polymer material, atomizing the melt using gas jet means in a manner to form atomized droplets, and cooling the droplets to form polymer particulates, which are collected for further processing. Atomization parameters can be controlled to produce polymer particulates with controlled particle shape, particle size, and particle size distribution. For example, atomization parameters can be controlled to produce spherical polymer powders, polymer whiskers, and combinations of spherical powders and whiskers. Atomizing apparatus also is provided for atoomizing polymer and metallic materials.

Abstract: A continuous process and apparatus for the production of at least approximately spherical, substantially solid particles, in which the particles are granulated in a circulating fluidized bed. This can be achieved by spraying a suspension or a solution of the solid which forms the particles into a chamber. A drying gas is passed through the chamber at a velocity which is sufficient to effect pneumatic conveying of already partially dried or agglomerated particles. The particles conveyed by the drying gas stream are separated from the exhaust gas stream and returned, at least in part, to the chamber. Particles with a size within the desired particle size range are continuously discharged from the chamber, such that the mass present in the chamber remains constant.

Abstract: The invention relates to a process and an apparatus for forming molten drops of precursors of thermoplastic polyesters or copolyesters as molten monomer, oligomer, monomer/glycol mixture or after partial polycondensator [sic] and melting to give a molten precursor, in which the precursor formed into drops is introduced into a gaseous medium, and the gaseous medium, after entry of the precursor formed into drops into the gaseous medium, accelerates the crystallization process by holding the drop-form precursor at a temperature above 100° C. and below its melting point for a limited time until crystallization of the drop at the surface of the precursor is complete. To this end, the apparatus has a fall tower, through which the gaseous medium flows in countercurrent from bottom to top, while the drops fall in the vertical direction from top to bottom into a collecting funnel with a precrystallized surface.

Abstract: The process comprises forming drops of a liquid to be configured, introducing said drops into a configurator liquid at high temperature in order to produce the coagulation of the drops and to obtain granules; to this effect, the jet of configuration liquid is subjected to the action of periodical pulses which are symmetrical to the axis of the effluent jet of configuration liquid thereby obtaining a controlled disintegration of the liquid into drops. The device for implementing such process includes a pulse chamber (2) with an elastic membrane (4) which produces pressure pulses to the liquid thereby disintegrating the liquid into drops (10) which fall into a receiver (12) and which, together with a configuration liquid flow, are introduced into a column (13) containing the configuration liquid at high temperature. The process and device enable to obtain granulated products such as caviar-like product, granulated meat products, chemical, pharmaceuticals and the like.

Abstract: This invention is for an improved process to formulate polymeric microspheres/nanospheres and encapsulate therapeutic proteins and other useful substances. Non-toxic supercritical or near-critical fluids with/without polar cosolvents are utilized to solubilize biodegradable polymers and form uniform polymer microspheres and nanospheres to encapsulate proteins with controlled-release characteristics.

Abstract: Spherical particles having a diameter between 0.007″ and 0.040″ are formed from melt extruded thermo-plastic material suitable for casting on a heated mold surface and melting thereon to form a thin layer of material having a nominal thickness of 0.040″ that is cooled and removed from the mold surface as a part having a porosity less than a visually observable threshold. The process includes the steps of providing microspheres formed of blended and melt extruded thermo-plastic, plasticizers and pigment additives that constitute less than 5% by weight of the blend and shaped as a smooth round spherical particle; providing a heated casting surface and distributing a predetermined charge of such microspheres against the heated casting surface; melting the microspheres as a layer of thermoplastic material having a porosity less than 0.003 inches and thereafter cooling and removing the non-porous layer from the casting surface.

Abstract: A method of producing magnesium chloride granules with a particle size in the range from 0.4 to 3.0 mm suitable for fluidization, air drying and chlorinating to anhydrous state, by preparing a feed solution of MgCl2 having a 30-55% by weight of MgCl2, feeding the solution and keeping it at high temperatures from the feeding tank to the nozzles, atomisation of the feed solution into the bed of already dried particles by pressure or compressed air, passing preheated air upwardly through the bed, maintaining the particles in a fluidizing state and a bed temperature between 100-170° C., continuously recovering entrained particles in a cyclone, discharging magnesium chloride particles continuously, classifying discharged material and recycling of any undersized fraction and crushed oversize fraction together with fines from the cyclone to the fluid bed for further granulation.

Abstract: A method of transforming a molten material or melt into discrete solid particles comprises forming the melt into prills by passing the melt through a perforated member, dropping the prills onto a bed of powdered material, such as silica flour, to coat the prills with the material in the bed and permitting the prills to cool, thereby to solidify into discrete solid particles. In one embodiment, the melt comprises at least two components such as elemental sulphur and an olefinic hydrocarbon, which are subjected to a chemical reaction, such as the polymerization of the olefinic hydrocarbon with the sulphur to form a sulphur polymer stabilizer. A method of producing a sulphur concrete incorporating the sulphur polymer stabilizer is also provided.

Abstract: A flash-spun material comprised of at least 90% by weight of polymers selected from the groups A, B, and C; wherein group A comprises polymers with a melting point above 280° C. that are comprised of halocarbon polymers in which at least 20% of the total number of halogen atoms in each halocarbon polymer are fluorine atoms; wherein group B comprises polymers with a melting point above 280° C. that are comprised of oxyhalocarbon polymers in which at least 20% of the total number of halogen atoms in each oxyhalocarbon polymer are fluorine atoms; and wherein group C comprises fully halogenated, highly fluorinated ion exchange polymers. A process for producing such flash-spun material and a solvent for producing such flash-spun material are also provided.

Abstract: There is disclosed an improved, energy-saving granulation method, wherein use is made of a granulator (1) having a bottom floor (9) of a granulation section whose bottom is a perforated plate, an upper air feed pipe (23) for feeding air for fluidization to the bottom floor of the granulation section, a lower air feed pipe (2), air feed pipes (3, 4, 5) branched from the lower air feed pipe for jetting air into the granulation section, and jetting nozzles (6, 7, 8) provided at the centers of the air outlets for jetting a molten raw material; which involves the steps of jetting a molten raw material from the jetting nozzles to approximately spherical nuclei in the granulation section, which have been fed after the particle diameter has been caused to be an average particle diameter of 0.4 to 3.0 mm, to form granules. There is also disclosed an improved granulator.

Abstract: Method for the production of seamless capsules in which capsule forming material passes from a heated carrier fluid to a cooled carrier fluid during formation and solidification of the capsules.

Abstract: The present invention is a unique process and apparatus for making a new matrix material called a shearform matrix which results in transformation of the morphology of a feedstock. The process is characterized by increasing the temperature of a nonsolubilized feedstock carrier to a point where it will undergo internal flow, followed by upwardly ejecting a stream of the feedstock and then subjecting it to disruptive fluid shear force which separates it into separate parts or masses which have a transformed morphology. The shearform matrix may include other ingredients such as oleaginous material and actives.

Abstract: A process for making pellets from a viscous material includes the steps of extruding the viscous material from a first conduit into a pelletizing fluid in a first zone; and passing the extruded viscous material and pelletizing fluid into a second zone having an increase in the velocity of the pelletizing fluid and a step-wise reduction in the pressure relative to the first zone. Advantageously, this step change combination produces sufficient forces by the pelleting fluid on the viscous material sufficiently to form discrete pellets of a substantially uniform size distribution.

Abstract: The present invention relates to an atomization apparatus and method for the formation of substantially uniform, at least nearly spherical particles, particularly for the formation of metal particles. The present invention provides an atomization apparatus having a nozzle positioned at the bottom of a cooling chamber. Rayleigh wave instability may be induced by imparting vibrations to a stream of molten material which is released in an upward direction. This produces uniform droplets having an initial velocity sufficient to increase the residence time of the droplets in an inert atmosphere. The parabolic trajectory of the droplets over a 2 m vertical displacement is approximately five times longer than a freefall, thus significantly increasing the cooling time without increasing the cooling chamber height. Further the kinetic energy of each droplet is much lower throughout its trajectory which serves to improve the formation of spherical shaped particles and to lower the impact velocity.

Abstract: Pearls of an active principle exhibiting an indefinite crystallization point, wherein said pearls exhibit a prolonged, immediate or combination release profiles, are made by melting the active principle and a crystallization excipient to create a molten mixture; introducing the mixture into feed receptacles of a prilling tower; passing the mixture through a nozzle which is vibrated to form pearls; and allowing the pearls to fall in the tower countercurrentwise to cold air, where the tower is provided with a fluidized bed proximate the bottom of the tower and the temperature conditions of the said fluidized bed are maintained depending on the release profile desired.

Abstract: Prills are prepared by melting a salt and introducing the molten salt into carrier liquid. Oxidizing salts of ammonia, ammonium nitrate (AN) and ammonium dinitramide (ADN) are melted with a stabilizer and introduced by dry nitrogen pressure into an inert, perfluorinated carrier liquid of greater specific gravity than the molten salts. In a first embodiment, the carrier liquid is quiescent and below the salt solidification temperature so that prills solidify from drops of the salt rising through a column which substantially retains the liquid. In a second and continuous embodiment, the carrier liquid is initially above the solidification temperature, and the salt is injected into the moving liquid which passes with the molten salt in turbulent flow through a heated conduit, in which stationary vanes disperse the salt into droplets, and then through a cooled conduit for solidification of the salt into prills without agglomeration.

Abstract: The present invention provides a process for preparing granular urea, which solves the problem of removing moisture in a prilling tower method and the problem of concentrating diluted formaldehyde in granulation by a fluidized, spouted bed method when urea is granulated in the presence of formaldehyde. That is, the present invention provides a process for preparing granular urea from liquid drops or sprayed drops of a urea solution, wherein the urea solution is divided into two portions of a urea solution A and a urea solution B, and a urea solution prepared by mixing an aqueous formaldehyde solution with the urea solution A, concentrating the above mixed solution and then mixing it with the urea solution B is used.

Abstract: Aramid sheet material and parts molded therefrom comprising m-aramid fibrids containing up to 10% by weight dyes that are thermally stable up to the glass transition temperature of the m-aramid polymer and p-aramid or m-aramid short fibers.

Abstract: New alkali metal cyanide granulates based on sodium cyanide or potassium cyanide and a method for their preparation are disclosed. Commercially available alkali metal cyanide granulates consist of irregular particles; disadvantages are in particular the tendencies to form dust and to cake. The disclosed alkali metal cyanide granulates demonstrate a reduced tendency to cake and virtually no abrasion. The granulates are characterized by essentially spherical particles with particle diameters in the range 0.1 to 20 mm, a bulk density of more than 600 g/dm.sup.3, an abrasion of less than 1%, and a caking index of at most 4. The granulates can be prepared by fluidized bed spray granulation involving spraying an aqueous solution containing alkali metal cyanide onto alkali metal cyanide nuclei in a fluidized bed and evaporating the water.

Abstract: A process and an apparatus for producing a preform for plastic optical fiber having a refractive index distribution in which the refractive index is gradually decreased from the center of the preform toward the outer periphery thereof, by depositing a deposition layer comprising a polymer A (refractive index: N.sub.a) and a refractive index modifier having a refractive index different from that of the polymer A onto a surface of a rod member rotating about an axis thereof, by use of vapor-phase deposition based on a CVD (Chemical Vapor Deposition) process, or a coating process. A plastic optical fiber preform including deposition layers having a gradually decreasing refractive index distribution is formed by changing the mixing ratio between the polymer A and the refractive index modifier constituting the deposition layer.

Abstract: A method and an apparatus useful for the production of microparticles and nanoparticles are disclosed in which a compressed fluid and a solution including a solvent and a solute are introduced into a nozzle to produce a mixture. The mixture is then passed out of the nozzle to produce a spray of atomized droplets. The atomized droplets are contacted with a supercritical antisolvent to cause depletion of the solvent in the droplets so that particles are produced from the solute. Preferably, these particles have an average diameter of 0.6 .mu.m or less. The invention can be used in the pharmaceutical, food, chemical, electronics, catalyst, polymer, pesticide, explosives, and coating industries, all of which have a need for small-diameter particles.

Abstract: The disclosure is a more economical process for producing fibrets of superior quality by directing a dope comprising a cellulose derivative and a suitable solvent therefor into a coagulant and exposing it there to a shearing field to coagulate of the dope and form the fibrets. The fibrets, the solvent and the coagulant are then separated off. The suspension formed from the dope and the coagulant is alternately accelerated and decelerated in the shearing field at least once, preferably at least twice. This makes it possible to maintain a high average degree of turbulence over a long distance, so that a dope of high viscosity can be processed. In the apparatus for producing fibrets, the at least one nozzle (46-49) is disposed within a dispersing facility (40) comprising rotor (44) and stator (43, 45) and further comprising at least two sprockets (50-53), of which at least one sprocket (50) is part of the rotor (44) of the dispersing facility (40).

Abstract: The present invention relates to a process for the preparation of particles each comprising an excipient forming a matrix and at least one active ingredient uniformly distributed in the mass of said matrix, said process, which comprises the operations of extrusion and then lyophilization, being characterized in that it comprises the steps consisting of(1.) the preparation of a homogeneous mixture from(a) at least one active ingredient,(b) a physiologically acceptable hydrophilic excipient, and(c) waterto give a pasty mixture with a viscosity below 1 Pa.s, measured at room temperature (15.degree.-20.degree. C.);(2.) the extrusion of the resulting homogeneous mixture and the cutting of the extrudate to give moist particles;(3.) the freezing of the resulting particles as they fall under gravity through a stream of inert gas at a temperature below 0.degree. C.; and(4.) the freeze drying of said particles.

Abstract: Improved methods and apparatus for particle precipitation and coating using near- or supercritical fluid conditions are described. A fluid dispersion having a continuous phase dispersant and at least one precipitatable substance therein is contacted with a supercritical fluid (SCF) antisolvent so as to generate focused high frequency antisolvent sonic waves, breaking up the dispersion into extremely small droplets; the enhanced mass transfer rates between the droplets and the antisolvent causes precipitation of very small particles on the order of 0.1-10 .mu.m. In coating processes, a turbulent fluidized flow of core particles is created using an SCF antisolvent in an enclosed zone. The core particles are contacted therein at near- or supercritical conditions by a fluid dispersion containing a dispersant together with a precipitatable substance. The antisolvent depletes the dispersant and the substance is precipitated onto the fluidized core particles.

Abstract: To provide an oil supplying means for an oil coating roller, by which oil can be supplied stably for a long time while preventing offset, a cylindrical non-sintered molded body which is a mixture of ceramic fiber and clay is used as an oil holding member in an oil coating roller.