With Treatment Subsequent To Solid Wall Formation (e.g., Coating, Hardening, Etc.) Patents (Class 264/4.3)
  • Patent number: 11052158
    Abstract: Provided are liposome constructs for delivery of urea to the vitreoretinal interface of the eye. The liposome constructs are agglomerates of small lamellar vesicles (SUVs) and have a greater density than the vitreal fluid, such that they sink to the back of the eye rather than dispersing throughout the vitreous.
    Type: Grant
    Filed: August 18, 2017
    Date of Patent: July 6, 2021
    Inventor: Troy Bremer
  • Patent number: 11033520
    Abstract: Provided herein includes methods and compositions for the treatment of cancer. Described herein are liposome encapsulated chemotherapeutic agents, encompassing a weakly basic anticancer compound and an acid or salt thereof, wherein the acid is oxalic acid or tartaric acid and methods for preparing and utilizing the same.
    Type: Grant
    Filed: September 1, 2017
    Date of Patent: June 15, 2021
    Assignee: IRISYS, INC.
    Inventors: Igor Nikoulin, Gerald Yakatan, Yevgeniya Plekhov, Robert Giannini
  • Patent number: 10913968
    Abstract: The invention relates to a mass-spectrometric method to determine microbial resistances to antibiotics, in which the microbes are cultured in a medium comprising an antibiotic, and a mass spectrum of the microbes is acquired after they have been cultured. The method is characterized by the fact that any microbial growth taking place during the culture is mass-spectrometrically determined with the aid of a reference substance, which is added in a dosed amount and is co-measured in the mass spectrum, wherein a growth in microbes indicates the resistance to the antibiotic.
    Type: Grant
    Filed: June 15, 2018
    Date of Patent: February 9, 2021
    Inventors: Christoph Lange, Katrin Sparbier
  • Patent number: 10772841
    Abstract: Described herein are abuse deterrent controlled release oral pharmaceutical compositions comprising and methods for making the same. In particular, an abuse deterrent controlled release oral pharmaceutical composition comprising a soft capsule and an abuse deterrent controlled release matrix comprising an active pharmaceutical ingredient are described.
    Type: Grant
    Filed: April 6, 2015
    Date of Patent: September 15, 2020
    Assignee: PATHEON SOFTGELS INC.
    Inventors: Saujanya Gosangari, George Vamvakas, Tatyana Dyakonov, Aqeel Fatmi
  • Patent number: 10772842
    Abstract: Described herein are abuse deterrent controlled release oral pharmaceutical compositions comprising and methods for making the same. In particular, an abuse deterrent controlled release oral pharmaceutical composition comprising a soft capsule and an abuse deterrent controlled release matrix comprising an active pharmaceutical ingredient are described.
    Type: Grant
    Filed: October 7, 2015
    Date of Patent: September 15, 2020
    Assignee: PATHEON SOFTGELS INC.
    Inventors: Saujanya Gosangari, Justin Hughey, Tatyana Dyakonov, George Vamvakas, Aqeel A. Fatmi
  • Patent number: 10751418
    Abstract: The present invention is embodied by a composition capable of chaperoning a typically non-orally available therapeutic or diagnostic agent through the environment of the digestive tract such that the therapeutic or diagnostic agent is bioavailable. The composition may or may not be targeted to specific cellular receptors, such as hepatocytes. Therapeutic agents include, but are not limited to, insulin, calcitonin, serotonin, and other proteins. Targeting is accomplished with biotin or metal based targeting agents.
    Type: Grant
    Filed: March 5, 2013
    Date of Patent: August 25, 2020
    Assignee: SDG, Inc.
    Inventors: W. Blair Geho, John R. Lau
  • Patent number: 10660960
    Abstract: An ophthalmic drug delivery system that contains phospholipid and cholesterol for prolonging drug lifetime in the eyes.
    Type: Grant
    Filed: February 5, 2018
    Date of Patent: May 26, 2020
    Assignees: TAIWAN LIPOSOME CO., LTD., TLC BIOPHARMACEUTICALS, INC.
    Inventors: Sheue-Fang Shih, Po-Chun Chang, Yun-Long Tseng, Luke S. S. Guo, Keelung Hong
  • Patent number: 10653780
    Abstract: The present invention provides superior compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells in vivo. The compositions of the present invention are highly potent, thereby allowing effective knock-down of specific target proteins at relatively low doses. In addition, the compositions and methods of the present invention are less toxic and provide a greater therapeutic index compared to compositions and methods previously known in the art.
    Type: Grant
    Filed: August 28, 2015
    Date of Patent: May 19, 2020
    Assignees: THE UNIVERSITY OF BRITISH COLUMBIA, ARBUTUS BIOPHARMA CORPORATION
    Inventors: Michael J. Hope, Sean C. Semple, Jianxin Chen, Thomas D. Madden, Pieter R. Cullis, Marco A. Ciufolini, Barbara Low Shoud Mui
  • Patent number: 10646613
    Abstract: The present invention refers to a composition, comprising hemoglobin or myoglobin, wherein in at least 40% of said hemoglobin or myoglobin the oxygen binding site is charged by a non-O2 ligand, and at least one further ingredient, a method for preparing said composition and the use of hemoglobin or myoglobin charged with a non-oxygen ligand for external treatment of wounds.
    Type: Grant
    Filed: July 23, 2012
    Date of Patent: May 12, 2020
    Assignee: MÖLNLYCKE HEALTH CARE AB
    Inventors: Michael Sander, Harald Potzschke
  • Patent number: 10624860
    Abstract: Materials and methods for preparing a payload-containing microcapsule with walls that have hexahydrotriazine (HT) and/or hemiaminal (HA) structures are disclosed. To an HT small molecule or a HA small molecule, or a combination thereof, in a solvent is added a cross-linking agent, NH4Cl, and a copolymer. The solution is acidified, and a payload agent is added. The HT small molecule and HA small molecule may have orthogonal functionality.
    Type: Grant
    Filed: March 21, 2017
    Date of Patent: April 21, 2020
    Assignee: International Business Machines Corporation
    Inventors: Dylan J. Boday, Jeannette M. Garcia, James L. Hedrick, Brandon M. Kobilka, Jason T. Wertz, Rudy J. Wojtecki
  • Patent number: 10596081
    Abstract: A composition includes: an aqueous composition (A) including a buffer having a pKa between 4.0 and 8.0 and having no more than one carboxylic acid function; and at least one capsule including a core and a gelled shell including a polyelectrolyte in the gelled state chelated by divalent cations, the shell fully encapsulating the core on the periphery thereof, the capsule being free of eukaryote cells.
    Type: Grant
    Filed: November 14, 2014
    Date of Patent: March 24, 2020
    Assignee: CAPSUM
    Inventors: Thomas Delmas, Mathieu Goutayer
  • Patent number: 10584245
    Abstract: A renewable material for releasing a self-healing agent includes a renewable polymeric substrate with capsules and a reactant dispersed in the renewable polymeric substrate. The capsules may be formed from a first renewable shell polymer and may enclose the renewable self-healing agent. The reactant may be suitable for reacting with the renewable self-healing agent to form a polymer.
    Type: Grant
    Filed: July 24, 2018
    Date of Patent: March 10, 2020
    Assignee: International Business Machines Corporation
    Inventors: Dylan J. Boday, Jason T. Wertz
  • Patent number: 10584246
    Abstract: A renewable material for releasing a self-healing agent includes a renewable polymeric substrate with capsules and a reactant dispersed in the renewable polymeric substrate. The capsules may be formed from a first renewable shell polymer and may enclose the renewable self-healing agent. The reactant may be suitable for reacting with the renewable self-healing agent to form a polymer.
    Type: Grant
    Filed: July 24, 2018
    Date of Patent: March 10, 2020
    Assignee: International Business Machines Corporation
    Inventors: Dylan J. Boday, Jason T. Wertz
  • Patent number: 10449149
    Abstract: The disclosure provides methods for preparation of carbohydrate replacement therapies (CRT) that include nanocarriers of carbohydrates and glycolipids for pharmaceutical delivery to cell interior, endoplasmic reticulum, and Golgi for treating CDG type I and CDG type II diseases as well as other metabolic disorders.
    Type: Grant
    Filed: October 19, 2017
    Date of Patent: October 22, 2019
    Assignee: Glycomine, Inc.
    Inventors: Agnes Rafalko, Tatyana Chernenko
  • Patent number: 10391056
    Abstract: The present invention provides a pharmaceutical composition comprising at least one hydrophobic camptothecin derivative or a pharmaceutically acceptable salt of said derivative and a polyethylene glycol (PEG) conjugated phospholipid. Also provided is a method to inhibit cancer cells in a subject in need thereof by administering the pharmaceutical composition of the present invention.
    Type: Grant
    Filed: November 2, 2012
    Date of Patent: August 27, 2019
    Assignees: Taiwan Lipsome Company, LTD., TLC Biopharmaceuticals, Inc.
    Inventors: Pei Kan, ChiaHung Hung, KeeIung Hong, Yun-Long Tseng, Yung-Hsu Chan
  • Patent number: 10293367
    Abstract: The present invention provides a waterproof tape having improved adhesion which comprises a filler layer having formed on one side of a base film to exhibit excellent viscosity while being thin and has excellent shock resistance and an excellent waterproof property, and a manufacturing method.
    Type: Grant
    Filed: February 25, 2015
    Date of Patent: May 21, 2019
    Assignee: NDFOS CO., LTD.
    Inventor: Chang Hoo Lee
  • Patent number: 10293366
    Abstract: The present invention provides a waterproof tape for an automobile battery which comprises a filler layer having formed on one side of a base film to exhibit excellent viscosity while being thin and has excellent shock resistance and an excellent waterproof property, and a manufacturing method.
    Type: Grant
    Filed: February 25, 2015
    Date of Patent: May 21, 2019
    Assignee: NDFOS CO., LTD.
    Inventor: Chang Hoo Lee
  • Patent number: 10278898
    Abstract: Disclosed is a method for shortening the drying time for drying an encapsulated material including a coating material containing water without causing deformation of the coating when drying. The method employs a fluidized bed dryer for drying coating materials that contain water and that form a coating when the water evaporates. A first drying step involves floating and fluidizing the encapsulated material and limiting a theorisable evaporating water content ?W so that dimples or deformation do not occur in the coating of the encapsulated granular material while measuring a water content or temperature of gas exhausted from the fluidized bed dryer; and a second drying step, performed after the measure water content is reduced below a prescribed amount or the measured temperature has increased, of blowing in gas to the fluidized bed dryer so that the theorisable evaporating water content ?W rises above that during the first drying step.
    Type: Grant
    Filed: June 26, 2014
    Date of Patent: May 7, 2019
    Assignee: R.P. Scherer Technologies, LLC
    Inventors: Naoji Sawaguchi, Yuji Amano, Yuichiro Sakurai
  • Patent number: 10272043
    Abstract: The present invention comprises methods and compositions for the reduction of oxalate in humans. For example, the invention provides methods and compositions for the delivery of one or more oxalate-reducing enzymes embedded in particle compositions. The compositions of the present invention are suitable in methods of treatment or prevention of oxalate-related conditions including, but not limited to, hyperoxaluria, absorptive hyperoxaluria, enteric hyperoxaluria, primary hyperoxaluria, idiopathic calcium oxalate kidney stone disease (urolithiasis), vulvodynia, oxalosis associated with end-stage renal disease, cardiac conductance disorders, inflammatory bowel disease, Crohn's disease, ulcerative colitis, and patients who have undergone gastrointestinal surgery and bariatric surgery (surgery for obesity), and/or who have undergone antibiotic treatment.
    Type: Grant
    Filed: October 27, 2014
    Date of Patent: April 30, 2019
    Assignee: OXTHERA INTELLECTUAL PROPERTY AB
    Inventors: Qingshan Li, Harmeet Sidhu
  • Patent number: 10258629
    Abstract: Provided herein are compositions methods of using liposomally encapsulated therapeutic drugs, such as staurosporine. Further provided herein are methods of using the liposome compositions to treat a cancer.
    Type: Grant
    Filed: March 27, 2015
    Date of Patent: April 16, 2019
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Santosh Kesari, Rajesh Mukthavaram, Milan T. Makale, Wolfgang J. Wrasidlo
  • Patent number: 10182997
    Abstract: The present invention provides a compositions and methods for the treatment of cancer, including pancreatic cancer, breast cancer and melanoma, in a human patient. The methods and compositions of the present invention employ curcumin or a curcumin analog encapsulated in a colloidal drug delivery system, preferably a liposomal drug delivery system. Suitable colloidal drug delivery systems also include nanoparticles, nanocapsules, microparticles or block copolymer micelles. The colloidal drug delivery system encapsulating curcumin or a curcumin analog is administered parenterally in a pharmaceutically acceptable carrier.
    Type: Grant
    Filed: March 14, 2016
    Date of Patent: January 22, 2019
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Razelle Kurzrock, Lan Li, Kapil Mehta, Bharat Aggarwal
  • Patent number: 10159688
    Abstract: The present invention includes methods and compositions to enhance, inter alia, wound repair by administration of 2,3-biphosphoglycerate, myo-inositol trispyrophosphate, or a functional variant thereof.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: December 25, 2018
    Assignee: M. ALPHABET 3, L.L.C.
    Inventors: Howard Fein, Joshua M. Berlin
  • Patent number: 10131901
    Abstract: Methods, systems and apparatus for automated extraction, purification, and processing of nucleic acids from biological samples are presented. In some embodiments, hydrogel supports are used to immobilize particulate biological input samples and extract nucleic acids during operations. The use of hydrogel facilitates automated sample processing on robotic liquid handling systems. Devices, methods, and systems are also provided for electrophoretic sample preparation.
    Type: Grant
    Filed: October 15, 2015
    Date of Patent: November 20, 2018
    Assignee: SAGE SCIENCE, INC.
    Inventors: Ezra S. Abrams, Danny Yun, Todd J. Barbera, Douglas Grosvenor Sabin, T. Christian Boles
  • Patent number: 10111871
    Abstract: The invention provides pharmaceutical formulations of inhibitors for poly (ADP-ribose) polymerase (PARP) enzyme. The formulations can be used in the treatment and prevention of cancer as well as the treatment of neurotrauma and neurodegenerative diseases. The PARP inhibitor is delivered in the form of nanoparticles that provide efficient delivery of the inhibitor into cancer cells or other cells and release of the inhibitor within the cells. In treating cancer, the result is killing of tumor cells, whereas in treatment of neurotrauma and neurodegenerative disease, the result is preservation of cell function.
    Type: Grant
    Filed: August 27, 2014
    Date of Patent: October 30, 2018
    Assignee: Northeastern University
    Inventors: Shifalika Tangutoori, Srinivas Sridhar
  • Patent number: 10034819
    Abstract: The invention relates to a method of making multilayer core/shell microcapsules for delivery of active agents such as fragrance components of perfume oils. The method includes forming an outer shell by coacervation surrounding an internal phase which contains the active agent; and forming an inner shell by interfacial polymerization at the interface between the internal phase and the outer shell. The internal phase contains the active agent. The microcapsules are typically incorporated in a consumer product wherein the multilayer shell prevents the active agent from release until desired, generally during use of the consumer product.
    Type: Grant
    Filed: September 23, 2013
    Date of Patent: July 31, 2018
    Assignee: Firmenich SA
    Inventors: Grégory Dardelle, Marlène Jacquemond, Philipp Erni
  • Patent number: 10030091
    Abstract: Compositions may include a monomer, an organic crosslinker, an inorganic crosslinker, and an initiator. Furthermore, compositions may include at least one monomer and triethoxyvinylsilane (TEVS) to provide crosslinking among the at least one monomer.
    Type: Grant
    Filed: September 11, 2014
    Date of Patent: July 24, 2018
    Assignee: M-I L.L.C.
    Inventors: Changping Sui, Balakrishnan Panamarathupalayam
  • Patent number: 10022349
    Abstract: Cadotril particles suitable for solid or liquid dosage forms are the subject of this application.
    Type: Grant
    Filed: October 29, 2015
    Date of Patent: July 17, 2018
    Assignee: Johnson & Johnson Consumer Inc.
    Inventors: Saumitra Bagchi, Murali K. Vuppala
  • Patent number: 10011860
    Abstract: The invention relates to a mass-spectrometric method to determine microbial resistances to antibiotics, in which the microbes are cultured in a medium comprising an antibiotic, and a mass spectrum of the microbes is acquired after they have been cultured. The method is characterized by the fact that any microbial growth taking place during the culture is mass-spectrometrically determined with the aid of a reference substance, which is added in a dosed amount and is co-measured in the mass spectrum, wherein a growth in microbes indicates the resistance to the antibiotic.
    Type: Grant
    Filed: April 3, 2014
    Date of Patent: July 3, 2018
    Inventors: Christoph Lange, Katrin Sparbier
  • Patent number: 9976008
    Abstract: The present invention relates to porous inorganic/organic homogenous copolymeric hybrid material materials, including particulates and monoliths, methods for their manufacture, and uses thereof, e.g., as chromatographic separations materials.
    Type: Grant
    Filed: December 14, 2015
    Date of Patent: May 22, 2018
    Assignee: Waters Technologies Corporation
    Inventors: Zhiping Jiang, John E. O'Gara, Raymond P. Fisk, Kevin D. Wyndham, Darryl W. Brousmiche
  • Patent number: 9962321
    Abstract: Consumer products including compositions that include coated microcapsules, said coated microcapsules including a polymeric shell and a liquid core material encapsulated therein; and a metallic coating surrounding said microcapsules and methods related thereto.
    Type: Grant
    Filed: December 16, 2015
    Date of Patent: May 8, 2018
    Assignee: Noxell Corporation
    Inventors: Elaine Alice Marie Baxter, Simon Richard Biggs, Olivier Jean Cayre, Zoë Dyter, James Paul Hitchcock, Lynette Anne Makins Holland, Madhuri Jayant Khanolkar, Raul Rodrigo Gomez, Alison Louise Tasker, David William York
  • Patent number: 9951294
    Abstract: Accordingly, there are provided coated microcapsules including: a microcapsule including a polymeric shell and a liquid core material encapsulated therein; and a metallic coating surrounding said microcapsule, wherein the metallic coating includes particles of a first metal adsorbed on said polymeric shell and a film of a second metal formed thereon; wherein the particles of the first metal are sterically-stabilized nanoparticles; processes for preparing the coated microcapsules, as well as formulations related thereto are also provided.
    Type: Grant
    Filed: December 16, 2015
    Date of Patent: April 24, 2018
    Assignee: Noxell Corporation
    Inventors: James Paul Hitchcock, Elaine Alice Marie Baxter, Simon Richard Biggs, Olivier Jean Cayre, Lynette Anne Makins Holland, Alison Louise Tasker
  • Patent number: 9951293
    Abstract: Accordingly, there are provided coated microcapsules including: a microcapsule including a polymeric shell and a liquid core material encapsulated therein; and a metallic coating surrounding said microcapsule, wherein the metallic coating comprises particles of a first metal adsorbed on said polymeric shell and a film of a second metal formed thereon; wherein said particles of the first metal are charge-stabilized nanoparticles; processes for preparing the coated microcapsules, as well as formulations related thereto are also included.
    Type: Grant
    Filed: December 16, 2015
    Date of Patent: April 24, 2018
    Assignee: Noxell Corporation
    Inventors: James Paul Hitchcock, Elaine Alice Marie Baxter, Simon Richard Biggs, Olivier Jean Cayre, Lynette Anne Makins Holland, Alison Louise Tasker
  • Patent number: 9944886
    Abstract: Accordingly, there are provided coated microcapsules including a microcapsule, said microcapsules including a polymeric shell and a liquid core material encapsulated therein; and a metallic coating surrounding said microcapsules; wherein the metallic coating includes particles of a first metal adsorbed on said polymeric shell and a film of a second metal formed thereon; and wherein the metallic coating has a maximum thickness of 1000 nm; and methods and formulations related thereto.
    Type: Grant
    Filed: December 16, 2015
    Date of Patent: April 17, 2018
    Assignee: Noxell Corporation
    Inventors: James Paul Hitchcock, Elaine Alice Marie Baxter, Simon Richard Biggs, Olivier Jean Cayre, Zoë Dyter, Lynette Anne Makins Holland, Madhuri Jayant Khanolkar, Raul Rodrigo Gomez, Alison Louise Tasker, David William York
  • Patent number: 9944887
    Abstract: Accordingly, there are provided coated microcapsules including: a microcapsule including a polymeric shell and a liquid core material encapsulated therein; and a metallic coating surrounding said microcapsule, wherein the metallic coating includes particles of a first metal adsorbed on said polymeric shell and a film of a second metal formed thereon; wherein the particles of the first metal are adsorbed on said polymeric shell by contacting the polymeric shell with a reducing agent and a solution comprising ions of the first metal, thereby reducing said ions and forming particles of the first metal adsorbed on said polymeric shell; method and formulations related thereto are also provided.
    Type: Grant
    Filed: December 16, 2015
    Date of Patent: April 17, 2018
    Assignee: Noxell Corporation
    Inventors: Alison Louise Tasker, Elaine Alice Marie Baxter, Simon Richard Biggs, Olivier Jean Cayre, James Paul Hitchcock
  • Patent number: 9835618
    Abstract: Provided herein are systems for and methods of capturing, detecting, quantifying, and characterizing target moieties that are characterized by having a lipophilic portion of sufficient size and chemical composition whereby the target moiety inserts (or partitions) into a lipid assembly. Examples of such assays employ synthetic lipid constructs such as supported bilayers which are used to capture target moieties; other example assays exploit the natural absorption of compounds into natural lipid constructs such as HDL or LDL particles or cell membranes to capture target moieties. In specific embodiments, the target moieties are bacterial pathogen associated molecular pattern (PAMP) molecules or compounds not yet identified as PAMP molecules.
    Type: Grant
    Filed: June 21, 2012
    Date of Patent: December 5, 2017
    Assignee: Los Alamos National Security, LLC
    Inventors: Basil I. Swanson, Harshini Mukundan, Rama Murthy Sakamuri
  • Patent number: 9775789
    Abstract: Liposomal topical compositions containing phenolic anti-inflammatory agents, and methods for making thereof, are presented. These compositions are generally used for helping to prevent solar radiation-induced skin damage and helping to prevent and/or treat inflammatory dry skin conditions caused by eczema and contact dermatitis.
    Type: Grant
    Filed: December 6, 2013
    Date of Patent: October 3, 2017
    Assignee: D & J Rosée Inc.
    Inventor: Donald L. Simmons
  • Patent number: 9668974
    Abstract: The invention provides extended release pro-liposomal, non-aqueous, pharmaceutical formulations of a local anesthetic in the form of a clear oily solution and methods for making same. The formulations can be administered by infiltration into an incision, or by injection.
    Type: Grant
    Filed: May 9, 2013
    Date of Patent: June 6, 2017
    Assignee: PAINREFORM LTD.
    Inventors: Shimon Amselem, Michael Naveh
  • Patent number: 9579261
    Abstract: Disclosed is a method for preparing a liposome formulation. In the disclosed method, a lipid fraction is dissolved in an organic solvent. The solution including a bioactive component and the lipid fraction, together with a carrier, is put in a reaction vessel, and a supercritical fluid is introduced thereto, so as to prepare particles coated with the bioactive component-lipid. The supercritical fluid is discharged by compression to obtain proliposome particles, and then the proliposome particles are hydrated by an aqueous solution including water so as to form a liposome solution. Preferably, the formulation may include one or more bioactive components. As required, the liposome formulation may be further processed by methods such as particle size reduction, removal of organic solvent, and freeze-drying. The preparation method can be easily carried out at a laboratory scale. Furthermore, the same method can be employed in liposome formulation preparation in mass production, or at a commercial scale.
    Type: Grant
    Filed: February 24, 2011
    Date of Patent: February 28, 2017
    Assignee: BCWORLD PHARM. CO., LTD.
    Inventors: Sung Joo Hwang, Hee Jun Park, Wonkyung Cho, Kwang-Ho Cha, Junsung Park, Chanhyuk Park, Donggeon Gu
  • Patent number: 9572755
    Abstract: The present invention is directed to a granulated composition comprising a salt encapsulated by a composition that comprises at least one wax.
    Type: Grant
    Filed: June 11, 2014
    Date of Patent: February 21, 2017
    Assignee: RECKITT BENCKISER (BRANDS) LIMITED
    Inventors: Verity Adams, Maida Ponchateau, Aimee Peachey, James Scott
  • Patent number: 9504651
    Abstract: The present invention provides apparatus and processes for producing liposomes. By providing a buffer solution in a first reservoir, and a lipid solution in a second reservoir, continuously diluting the lipid solution with the buffer solution in a mixing chamber produces a liposome. The lipid solution preferably comprises an organic solvent, such as a lower alkanol.
    Type: Grant
    Filed: June 13, 2014
    Date of Patent: November 29, 2016
    Assignee: PROTIVA BIOTHERAPEUTICS, INC.
    Inventors: Ian MacLachlan, Lloyd Jeffs, Lorne R. Palmer, Cory Giesbrecht
  • Patent number: 9468591
    Abstract: A sunscreen composition comprised of one or more sunscreen active agents encapsulated in a cellulose derived capsule wherein the composition can contain one or more additional agents. A sunscreen composition can be mixed with a bodywash, shampoo, conditioner, lotion, gel, soap, cream, hand sanitizer, spray or mousse and can be used by an individual during their normal hygiene processes, such as during a shower or bath or while applying a body product to their skin or hair.
    Type: Grant
    Filed: May 3, 2014
    Date of Patent: October 18, 2016
    Assignee: CoLabs International Corporation
    Inventor: Laura E. Cohen
  • Patent number: 9456967
    Abstract: A sunscreen composition comprised of one or more sunscreen active agents encapsulated in a cellulose derived capsule wherein the composition can contain one or more additional agents. A sunscreen composition can be mixed with a bodywash, shampoo, conditioner, lotion, gel, soap, cream, hand sanitizer, spray or mousse and can be used by an individual during their normal hygiene processes, such as during a shower or bath or while applying a body product to their skin or hair.
    Type: Grant
    Filed: May 3, 2014
    Date of Patent: October 4, 2016
    Assignee: CoLabs International Corporation
    Inventor: Laura E. Cohen
  • Patent number: 9456968
    Abstract: A sunscreen composition comprised of one or more sunscreen active agents encapsulated in a cellulose derived capsule wherein the composition can contain one or more additional agents. A sunscreen composition can be mixed with a bodywash, shampoo, conditioner, lotion, gel, soap, cream, hand sanitizer, spray or mousse and can be used by an individual during their normal hygiene processes, such as during a shower or bath or while applying a body product to their skin or hair.
    Type: Grant
    Filed: May 3, 2014
    Date of Patent: October 4, 2016
    Assignee: CoLabs International Corporation
    Inventor: Laura E. Cohen
  • Patent number: 9441070
    Abstract: Compositions containing a divinylarene dioxide and a hydroxy-substituted dioxide compound and having relatively low viscosity and reduced volatility are used as underfills in the manufacture of electronic assemblies.
    Type: Grant
    Filed: September 11, 2013
    Date of Patent: September 13, 2016
    Assignee: Rohm and Haas Electronic Materials LLC
    Inventor: Paul L. Morganelli
  • Patent number: 9333191
    Abstract: Provided herein are mast cell stabilizers used to prevent, treat, or mitigate severity of laminitis. Mast cell stabilizers can be combined with antihistamines and other medicaments to prevent, treat, or mitigate severity of laminitis.
    Type: Grant
    Filed: August 19, 2015
    Date of Patent: May 10, 2016
    Assignee: WILLOWCROFT PHARM INC.
    Inventor: Charles F. Owen
  • Patent number: 9220929
    Abstract: The invention relates to the use of a haemoglobin for the preparation of dressings and to the resulting dressings.
    Type: Grant
    Filed: June 10, 2008
    Date of Patent: December 29, 2015
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS, Hemarina, UNIVERSITE PIERRE ET MARIE CURE
    Inventors: Franck Zal, Morgane Rousselot
  • Patent number: 9187577
    Abstract: A filled nanoparticle includes a nanosized polymer shell encapsulating a reactive chemical. In another aspect, a filled nanoparticle includes a nanosized polymer shell encapsulating a core which includes a reactive functional group attached to a polymer. A miniemulsion polymerization process of producing filled nanoparticles includes: providing a mixture comprising monomer, initiator or catalyst to aid polymerization, reactive chemical, surfactant and water; shearing the mixture to form a miniemulsion of nanosized particles dispersed in water, the nanosized particles comprising the monomer combined with the reactive chemical; and then heating the miniemulsion to polymerize the monomer and produce filled nanoparticles comprising a nanosized polymer shell encapsulating the reactive chemical.
    Type: Grant
    Filed: May 12, 2009
    Date of Patent: November 17, 2015
    Assignee: Battelle Memorial Institute
    Inventors: Ramanathan S. Lalgudi, Jeff J. Boyce, Barry L. McGraw
  • Patent number: 9155764
    Abstract: Red blood cell membrane derived microparticles (RMP) are safe, economical, effective hemostatic agents in the treatment of a wide range of bleeding conditions and can be considered as universal hemostatic agents. RMP are produced from red blood cells using a high-pressure extrusion membrane shear process and can be lyophilized after production and retain activity even when stored at room temperature. RMP can be administered to original donors (autologous treatment), thus avoiding transfusion complications, or can be administered to blood type compatible recipients. RMP produced from type O, Rh negative red cells can be given to any person regardless of blood type. RMP can be administered to reduce excessive bleeding resulting from trauma, surgeries, invasive procedures and various bleeding disorders such as platelet disorders, either congenital or acquired, and coagulation disorders, either congenital or acquired.
    Type: Grant
    Filed: January 24, 2012
    Date of Patent: October 13, 2015
    Assignee: University of Miami
    Inventors: Yeon S. Ahn, Wenche Jy, Lawrence L. Horstman
  • Publication number: 20150137399
    Abstract: An extrusion process comprises extruding a material that is flowable when heated and passing the extrudate thus formed through a nozzle 10 to shape the extrudate into a plurality of substantially uniformly shaped elements such as minispheres or minicapsules.
    Type: Application
    Filed: December 30, 2014
    Publication date: May 21, 2015
    Applicant: SIGMOID PHARMA LTD.
    Inventor: Ivan Coulter
  • Publication number: 20150130096
    Abstract: The polarization of nuclear spins of a material may be enhanced by encapsulating the material within a reverse micelle.
    Type: Application
    Filed: May 9, 2013
    Publication date: May 14, 2015
    Inventor: Andrew Joshua Wand