Microcapsule Wall Derived From Synthetic Polymer Patents (Class 264/4.33)
  • Patent number: 10434045
    Abstract: Polyurea capsule compositions. A subset of these compositions contain a plurality of capsules and a capsule formation aid, in which each of the capsules contains a polyurea wall and an oil core; the polyurea wall is formed of a reaction product of a polyisocyanate and a cross-linking agent in the presence of the capsule formation aid; and the oil core contains an active material. The polyisocyanate, cross-linking agent, and capsule formation aids are described herein. Also disclosed are methods of preparing polyurea capsule compositions, as well as consumer products containing one of these compositions.
    Type: Grant
    Filed: July 25, 2018
    Date of Patent: October 8, 2019
    Assignee: International Flavors & Fragrances Inc.
    Inventors: Yabin Lei, Li Xu, Lewis Michael Popplewell
  • Patent number: 10201795
    Abstract: The application describes an aqueous dispersion of microcapsules, wherein the shell of the microcapsules comprises at least one polyurea and the core comprises one or more lipophilic components with the proviso that the core does not contain a fragrance, and having a percentage of the shell weight with reference to the total weight of the capsules of 5 to 40% and wherein the microcapsules have a volume average diameter of 15 to 90 ?m and the dispersion comprises hydroxyalkylcellulose and the use of such a dispersion.
    Type: Grant
    Filed: October 27, 2015
    Date of Patent: February 12, 2019
    Assignee: BASF SE
    Inventors: Ewelina Burakowska-Meise, Wolfgang Denuell, Thomas Soltys, Emmanuel Julien Leon Christian Aussant, Addi Fadel, Ian Harrison
  • Patent number: 9914861
    Abstract: A microcapsule-type curable resin composition enables the mass production of microcapsules each encapsulating a curing agent and therefore can be produced at significantly low cost, and which has an excellent adhesion property and excellent storage stability. Particularly, a microcapsule-type curable resin composition can exhibit excellent low-temperature curability and an excellent curing rate when used for a screw member such as a screw and can exhibit a significantly superior effect when used for preventing the looseness of screws. A microcapsule-type curable resin composition includes microcapsules each encapsulating (a) a compound having at least three thiol groups; (b) a substance capable of being cured by reacting with the compound having at least three thiol groups; and (c) a binder capable of adhering the microcapsules to a material of interest. The curable resin composition can be used preferably for the adhesion of a screw member.
    Type: Grant
    Filed: October 8, 2014
    Date of Patent: March 13, 2018
    Assignee: THREEBOND CO., LTD.
    Inventors: Kunihiko Kamata, Kenji Kuboyama
  • Patent number: 9192908
    Abstract: A process of forming microcapsules is described. The microcapsule population is formed by providing an anionic or cationic, solid hydrophilic core material; providing an oil continuous phase, the oil continuous phase comprising one or more esters with chain length up to about 18 carbons. Emulsification is achieved by subjecting the mixture to high shear agitation and heating the mixture for a time sufficient to enable acid or amine acrylate or methacrylate and multifunctional acrylate or methacrylate to form a prepolymer which migrates to the anionic or cationic solid hydrophilic material, thereby forming prepolymers adhered to the hydrophilic core materials. Temperature is held or heating continued for a time sufficient to enable the prepolymer to flow onto and coalesce into a continuous film surface coating on the hydrophilic core material. Heating is carried out or light exposure or both for a time and temperature sufficient to cross link the prepolymers.
    Type: Grant
    Filed: April 17, 2013
    Date of Patent: November 24, 2015
    Assignee: Encapsys, LLC
    Inventor: Todd Arlin Schwantes
  • Patent number: 9109096
    Abstract: A thermally expandable microcapsule, which shows excellent heat resistance and a high expansion ratio and thereby can be suitably used for molding processes involving high shearing force, such as kneading molding, calender molding, extrusion molding, and injection molding. The thermally expandable microcapsule also provides a foamed product using the thermally expandable microcapsule. The thermally expandable microcapsule contains a shell made of a polymer; and a volatile expansion agent as a core agent encapsulated in the shell, the storage elastic modulus (E?) of the shell at a temperature of 200° C. and a frequency of 10 Hz being 1×105 N/m2 or more, the storage elastic modulus (E?) of the shell at a temperature of 250° C. and a frequency of 10 Hz being 1×105 N/m2 or more, and a maximum displacement amount measured by thermomechanical analysis being 300 ?m or more.
    Type: Grant
    Filed: June 4, 2014
    Date of Patent: August 18, 2015
    Assignee: SEKISUI CHEMICAL CO., LTD.
    Inventors: Yasuhiro Kawaguchi, Yoshiyuki Kosaka
  • Publication number: 20150133591
    Abstract: Anaerobic curing formulations for sealing and/or blocking screws, nuts, bolts and screw or sealing caps are described. The sealing formulation comprises at least one acrylic resin and phenoxy-polyethoxy sulphate. The self-locking formulation comprises at least one diacrylate, an acrylic resin, a microencapsulated polymerisation initiator and a microencapsulated polymerisation accelerator. A method is described for coating a polymerization accelerator to obtain a microencapsulated polymerisation accelerator.
    Type: Application
    Filed: May 18, 2012
    Publication date: May 14, 2015
    Applicant: Tecnologic 3 S.r.l.
    Inventors: Gaspare Aita, Antonio Calasso, JR.
  • Publication number: 20150087517
    Abstract: The present disclosure relates to the manufacturing of specifically targeting microcapsules comprising agrochemicals. More specifically, the disclosure relates to specifically targeting microcapsules, to which targeting agents are covalently linked at a ratio from about 0.01 ?g-to about 1 ?g targeting agents per square centimeter of the surface of the microcapsule, such that the microcapsules are capable of binding the agrochemicals contained in the microcapsules to a surface, and to agrochemical compositions comprising such microcapsules.
    Type: Application
    Filed: October 8, 2012
    Publication date: March 26, 2015
    Inventors: Peter Verheesen, Chris De Jonghe
  • Patent number: 8932714
    Abstract: A method for controlling a particle diameter and a particle diameter distribution of emulsion particles during manufacturing of an emulsion dispersion is provided. The method includes causing two or more types of liquids substantially immiscible with each other to continuously and sequentially pass through net bodies. The net bodies are disposed in a cylindrical flow passage at intervals of 5 to 200 mm, and the number of the net bodies is more than 50 and 200 or less. Each of the net bodies is equivalent to a gauze having a mesh number of 35 mesh to 4000 mesh in accordance with an ASTM standard and has a surface that intersects the direction of the flow passage. An emulsification apparatus used for the method includes a feed pump for feeding two or more types of liquids substantially immiscible with each other; and a cylindrical flow passage to which the two or more types of liquids fed by the feed pump are delivered.
    Type: Grant
    Filed: October 1, 2008
    Date of Patent: January 13, 2015
    Assignee: Nippon Oil Corporation
    Inventors: Toshikatsu Shoko, Yasuo Togami, Akira Takagi, Hideko Hayashi
  • Publication number: 20140314831
    Abstract: Disclosed is a recombinant polypeptide for facilitating membrane fusion. The recombinant polypeptide having a sequence with at least 80% sequence identity with the ectodomain of p14 fusion-associated small transmembrane (FAST) protein and having a functional myristoylation motif, a transmembrane domain from a FAST protein and a sequence with at least 80% sequence identity with the endodomain of p15 FAST protein. A targeting ligand can be added to the recombinant polypeptide for selective fusion. The recombinant polypeptide can be included in the membrane of a liposome, or the like, to facilitate the delivery of bioactive compounds, such as siRNA, or the recombinant polypeptide can be mixed with a lipid carrier and added to cultured cells to induce cell-cell fusion and heterokaryon formation.
    Type: Application
    Filed: September 29, 2011
    Publication date: October 23, 2014
    Applicant: Innovascreen Inc.
    Inventors: Roy Duncan, John Lewis, Roberto Justo De Antueno, Rae-Lynn Nesbitt, Eileen Kathryn Clancy
  • Patent number: 8859641
    Abstract: Particle in the shape of an encapsulated droplet comprising a core material and a shell material surrounding the core material, the shell material containing maleimide groups, preferably a copolymer of maleimide groups. The shell material contains a copolymer of styrene and maleic anhydride derivatives, of which more than 75 mole %, preferably more than 90 mole % is maleimide, and the average particle size is smaller than 300 nm. The particles are obtained by a process comprising by heating between 80° C. and 195° C., more preferably between 120° C. and 190° C. an ammonium salt of a maleic anhydride containing polymer in the presence of the core material.
    Type: Grant
    Filed: July 23, 2007
    Date of Patent: October 14, 2014
    Assignee: Topchim N.V.
    Inventor: Henk Jan Frans Van Den Abbeele
  • Patent number: 8852646
    Abstract: Implantable materials may be used in an iatrogenic site. Applications include radioopaque materials for fiducial marking. Applications include a method of treating a patient with a pharmaceutically acceptable implant system comprising implanting a collection of pharmaceutically acceptable, covalently-crosslinked hydrogel particles, wherein the collection comprises a plurality of sets of the particles, with the sets having different rates of biodegradation.
    Type: Grant
    Filed: January 25, 2013
    Date of Patent: October 7, 2014
    Assignee: Incept, LLC
    Inventors: Patrick Campbell, Amarpreet S. Sawhney
  • Patent number: 8716214
    Abstract: In a fragrance and/or aroma composition for the targeted release of fragrances and/or aromas in the form of a solid lipid nanoparticle (SLN) dispersion, in which lipid-based nanoparticles are present which are stabilized by an emulsifier monolayer, one or more membrane layers or other auxiliaries, the fragrances and/or aromas are included in the nanoparticles and/or in the emulsifier monolayer or the membrane layers.
    Type: Grant
    Filed: May 7, 2003
    Date of Patent: May 6, 2014
    Assignee: OTC GmbH
    Inventors: Gerd Dahms, Andreas Jung, Holger Seidel
  • Patent number: 8715543
    Abstract: A curing agent for unsaturated polyester resins is made by microencapsulating an organic peroxide curing agent in a polyurethane protective coating or shell.
    Type: Grant
    Filed: March 30, 2012
    Date of Patent: May 6, 2014
    Assignee: OCV Intellectual Capital, LLC
    Inventors: Mitsuru Akagawa, Takuya Yasuhara
  • Patent number: 8710958
    Abstract: A container having a radio frequency identification tag attached thereto by means of a stud or a radio frequency identification tag retainer projecting from the exterior surface of the container. The container can be used to contain medical products, and the container can be of various types, such as, for example, a bottle, a micro-well plate, a cartridge, a tube. In one embodiment, the container has a radio frequency identification tag affixed thereto. The container comprises a mouth, a neck, a body, and a bottom. The container can also have a closure, a septum, or an adapter for other components of an automated clinical analyzer. The neck is capable of receiving a closure. A stud or a radio frequency identification tag retainer projecting from the bottom of the container, preferably the center of the bottom of the container, serves to retain the radio frequency identification during the attachment of the radio frequency identification tag to the container.
    Type: Grant
    Filed: July 10, 2008
    Date of Patent: April 29, 2014
    Assignee: Abbott Laboratories
    Inventors: Tahua Yang, Michael A. Berek
  • Patent number: 8586098
    Abstract: A process is described for loading hydrophilic polymer particles with a water-insoluble solvent-soluble drug. The particles are preferably embolic agents. The method provides particles having little or no drug at the surface and in a surface layer, whereby the burst effect is minimised. The drug is precipitated in the core of the particle, leading to extended release. The drug is, for instance, paclitaxel, rapamycin, dexamethasone or ibuprofen.
    Type: Grant
    Filed: June 15, 2011
    Date of Patent: November 19, 2013
    Assignee: Biocompatibles UK Limited
    Inventors: Andrew Lennard Lewis, Yiqing Tang, Maria Victoria Gonzalez Fajardo
  • Publication number: 20130236557
    Abstract: Biocompatible intraocular implants, such as microparticles, include a prostamide component and a biodegradable polymer that is effective in facilitating release of the prostamide component into an eye for an extended period of time. The prostamide component may be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers. Or, the prostamide component may be encapsulated by the ploymeric component. The present implants include oil-in-oil emulsified implants or microparticles. Methods of producing the present implants are also described. The implants may be placed in eye to treat or reduce a at least one symptom of an ocular condition, such as glaucoma.
    Type: Application
    Filed: April 12, 2013
    Publication date: September 12, 2013
    Applicant: Allergan, Inc.
    Inventors: Patrick M. Hughes, Michele Boix, Christian Sarrazin, Marina Do
  • Patent number: 8493648
    Abstract: Provided are a method of fabricating an electrophoretic ink, the electrophoretic ink formed using the method, and an electrophoretic display having the same. The method of fabricating an electrophoretic ink includes dispersing pigment particles into a dielectric fluid; adding at least one monomer and an initiator into the dielectric fluid; and forming polymeric membranes surrounding the pigment particles in the dielectric fluid. Since the pigment particle surrounded by the polymeric membrane and the dielectric fluid in which the pigment particle is dispersed can be utilized as the electrophoretic ink as they are without a follow-up cleaning process, the method of fabricating the electrophoretic ink is simplified.
    Type: Grant
    Filed: April 22, 2010
    Date of Patent: July 23, 2013
    Assignee: Electronics and Telecommunications Research Institute
    Inventors: Chul Am Kim, Hyeonjung Yoo, Kyung Soo Suh, Seung Youl Kang
  • Patent number: 8394497
    Abstract: Microencapsulated particles having improved resistance to moisture and extended release capabilities are produced by microencapsulating the particles in a film-forming, cross-linked, hydrolyzed polymer.
    Type: Grant
    Filed: August 19, 2011
    Date of Patent: March 12, 2013
    Assignee: Encap Technologies, LLC
    Inventor: Robert G. Bayless
  • Publication number: 20130011453
    Abstract: A microcapsule composition comprising at least one polymer substantially disposed as a semi-permeable shell around a buffered solution and at least one therapeutic agent, wherein the therapeutic agent permeates the shell, and wherein the composition is suitable for delivery to a mammal. This invention also provides related compositions, products and methods.
    Type: Application
    Filed: September 14, 2012
    Publication date: January 10, 2013
    Applicant: Premier Dental Products Company
    Inventors: Mark A. Latta, Stephen M. Gross, William A. McHale
  • Patent number: 8349452
    Abstract: Microcapsules, comprising (A) in the range from 50 to 95 parts by weight, lipophilic core material which has a solid/liquid phase transition in the temperature range from ?20 to 120° C., (B) in the range from 4 to 50 parts by weight, capsule wall, and (C) in the range from 0.01 to 10 parts by weight, at least one colored or color-imparting substance selected from oil-soluble dyes and oil-soluble brighteners, where data in parts by weight are based on the total weight of the microcapsules in question.
    Type: Grant
    Filed: February 27, 2009
    Date of Patent: January 8, 2013
    Assignee: BASF SE
    Inventors: Marc Rudolf Jung, Juergen Reichert
  • Patent number: 8323794
    Abstract: Injectable hydrogel microspheres are prepared by forming an emulsion where hydrogel precursors are in a disperse aqueous phase and polymerizing the hydrogel precursors. In a preferred case, the hydrogel precursors are poly(ethylene glycol) diacrylate and N-isopropylacrylamide and the continuous phase of the emulsion is an aqueous solution of dextran and a dextran solubility reducer. The microspheres will load protein, e.g., cytokines, from aqueous solution.
    Type: Grant
    Filed: August 12, 2010
    Date of Patent: December 4, 2012
    Assignee: Cornell Research Foundation, Inc.
    Inventors: Chih-Chang Chu, Xian-Zheng Zhang, Da-Qing Wu
  • Publication number: 20120248639
    Abstract: A curing agent for unsaturated polyester resins is made by microencapsulating an organic peroxide curing agent in a polyurethane protective coating or shell.
    Type: Application
    Filed: March 30, 2012
    Publication date: October 4, 2012
    Inventors: Mitsuru Akagawa, Takuya Yasuhara
  • Patent number: 8246868
    Abstract: A W/O emulsion is produced from an aqueous solution containing a substance to be entrapped in a vesicle in a dissolved or suspended state and an oil phase containing an emulsifier; subsequently, the W/O emulsion is cooled to a temperature at which the aqueous solution of the W/O emulsion becomes a frozen particle and the oil phase maintains a liquid state, and the oil phase is removed; thereafter, an oil phase containing a vesicle constituent lipid is added to the frozen particle, and the obtained mixture is then stirred, so as to substitute the emulsifier on the surface of the frozen particle with the vesicle constituent lipid; and thereafter, an external Water phase is added to the frozen particle coated with a lipid membrane, so as to hydrate the lipid membrane by the external water phase. This process achieves a high entrapment yield of a desired substance while controlling desired physical properties such as particle diameter.
    Type: Grant
    Filed: March 3, 2008
    Date of Patent: August 21, 2012
    Assignee: University of Tsukuba
    Inventors: Sosaku Ichikawa, Takashi Kuroiwa
  • Patent number: 8246869
    Abstract: Photoactivatable prepolymers and methods of use thereof are disclosed for microencapsulation of a substantially water-insoluble material within a nonporous shell. As provided herein, the microencapsulated material is released with no more than a slow release rate. Upon exposure of the nonporous shell to light, the nonporous shell is converted into a porous shell having an increased release rate for the microencapsulated material.
    Type: Grant
    Filed: October 30, 2006
    Date of Patent: August 21, 2012
    Assignee: Solarbre, Inc.
    Inventor: Michael H. B. Stowell
  • Patent number: 8206621
    Abstract: A plasticized polymer of PLGA employing ethanol as the plasticizing agent prepared at a temperature higher than the Tg and lower than the boiling point of ethanol can be used in subcutaneous implants containing active ingredients therein.
    Type: Grant
    Filed: June 24, 2004
    Date of Patent: June 26, 2012
    Assignee: Mediolanum Pharmaceuticals Ltd.
    Inventors: Patrice Mauriac, Pierre Marion
  • Patent number: 8206826
    Abstract: A production method for heat-expandable microspheres, which have high expanding ratio and are thermally expanded into hollow particulates having excellent repeated-compression durability, and application thereof are provided. The method produces heat-expandable microspheres a shell of thermoplastic resin and a blowing agent being encapsulated therein and having a boiling point not higher than the softening point of the thermoplastic resin.
    Type: Grant
    Filed: May 14, 2008
    Date of Patent: June 26, 2012
    Assignee: Matsumoto Yushi-Seiyaku Co., Ltd.
    Inventors: Hiroki Naito, Satoshi Kawanami, Katsushi Miki, Ikuo Yosejima, Kenichi Kitano
  • Patent number: 8187672
    Abstract: Methods for preparing microparticles having reduced residual solvent levels. Microparticles are contacted with a non-aqueous washing system to reduce the level of residual solvent in the microparticles. Preferred non-aqueous washing systems include 100% ethanol and a blend of ethanol and heptane. A solvent blend of a hardening solvent and a washing solvent can be used to harden and wash microparticles in a single step, thereby eliminating the need for a post-hardening wash step.
    Type: Grant
    Filed: December 14, 2010
    Date of Patent: May 29, 2012
    Assignee: Alkermes Pharma Ireland Limited
    Inventors: Michael E. Rickey, J. Michael Ramstack, Rajesh Kumar
  • Patent number: 8076280
    Abstract: The present invention provides an emulsion comprising an organic discontinuous phase which is distributed throughout a continuous aqueous phase, wherein the organic phase comprises, a) an organic solvent which is a liquid at 25° C. and/or, b) an organic phase stabilising material that comprises hydrophobic moieties and is a material which is more soluble in the organic phase than the aqueous phase, and the emulsion further comprises an encapsulated fragrance, said fragrance is encapsulated in microparticles. The present invention also relates to personal care compositions comprising emulsions containing encapsulated fragrances for improved fragrance delivery. The present invention also relates a method of use that comprises application of an effective amount of a liquid or solid personal care composition comprising an emulsion that contains a fragrance encapsulated in microparticles to at least one part of the body.
    Type: Grant
    Filed: December 3, 2007
    Date of Patent: December 13, 2011
    Assignee: BASF SE
    Inventors: Stewart T. Elder, Christina L. Andrianov
  • Publication number: 20110293690
    Abstract: Films containing microsphere particles and processes for forming thereof are disclosed. The microsphere particles encapsulate one or more bioactive agents and may be deposited on a surface of medical devices or be used to form a medical device.
    Type: Application
    Filed: April 7, 2011
    Publication date: December 1, 2011
    Applicant: Tyco Healthcare Group LP
    Inventors: Jeremy Griffin, Amin Elachchabi, Joshua Stopek, Joshua Stopek
  • Patent number: 8057899
    Abstract: A nano-particle composition including a poly(alkenylbenzene) core and a poly (conjugated diene) or a poly(alkylene) surface layer is provided. The nano-particles have a mean average diameter less than about 100 nm. The nano-particles can be modified via, for example, hydrogenation or functionalization. The nano-particles can advantageously be incorporated into rubbers, elastomers, and thermoplastics.
    Type: Grant
    Filed: April 13, 2005
    Date of Patent: November 15, 2011
    Assignee: Bridgestone Corporation
    Inventors: Xiaorong Wang, Chenchy Jeffrey Lin, James Hall, Sandra Warren, James Krom, Hajime Kondo, Koichi Morita
  • Patent number: 8039015
    Abstract: Microcapsules possessing Lewis acid-Lewis base salt walls incorporate water-immiscible materials, such as N,N-diethyl-m-toluamide (DEET), as a core component. Such microcapsules, or similar microcapsules incorporating other core components, may be made by emulsifying a water-immiscible core component in an aqueous solution of one wall-forming reactant, such as the Lewis base, and then mixing that solution with the other wall-forming reactant, such as the Lewis acid. Various adjuvants may be included with the core component to contribute additional characteristics, such as enhancement of a controlled release characteristic or improved mechanical stability.
    Type: Grant
    Filed: December 7, 2005
    Date of Patent: October 18, 2011
    Inventor: Tycho J. Speaker
  • Publication number: 20110229916
    Abstract: The invention provides high enzyme loading nanofibers and processes utilized in their fabrication, the nanofibers suitable for use as a new class of highly sensitive and stable biosensors capable of monitoring glucose at low levels. The biosensors, comprising nanofiber enzyme materials fabricated from organic solvent-based polymer-enzyme systems, can be used effectively in non-invasive transdermal biosensing applications.
    Type: Application
    Filed: August 18, 2008
    Publication date: September 22, 2011
    Applicant: THE UNIVERSITY OF AKRON
    Inventors: Darrell H. Reneker, Songtao Wu, Ping Wang, Hongfei Jia, Ravindrabharathi Narayanan
  • Patent number: 8007831
    Abstract: A process is described for loading hydrophilic polymer particles with a water-insoluble solvent-soluble drug. The particles are preferably embolic agents. The method provides particles having little or no drug at the surface and in a surface layer, whereby the burst effect is minimised. The drug is precipitated in the core of the particle, leading to extended release. The drug is, for instance, paclitaxel, rapamycin, dexamethasone or ibuprofen.
    Type: Grant
    Filed: February 9, 2007
    Date of Patent: August 30, 2011
    Assignee: Biocompatibles UK Limited
    Inventors: Andrew Lennard Lewis, Yiqing Tang, Maria Victoria Gonzalez Fajardo
  • Patent number: 8003211
    Abstract: Microencapsulated particles having improved resistance to moisture and extended release capabilities are produced by microencapsulating the particles in a film-forming, cross-linked, hydrolyzed polymer.
    Type: Grant
    Filed: December 2, 2008
    Date of Patent: August 23, 2011
    Assignee: ENCAP Technologies, LLC
    Inventor: Robert G. Bayless
  • Patent number: 7943067
    Abstract: The present invention includes a method for preparing polymer hydrogel spherical particles on a nanometer scale (nanogels). The method includes encapsulating hydrogel-forming components into liposomes, diluting the large unilamellar liposomes suspension to prevent polymerization outside the liposomes, and polymerizing the encapsulated hydrogel-forming components. The lipid bilayer may be solubilized with detergent. The phospholipid and detergent molecules and their micelles may then be removed by dialysis. The resulting nanogels may then be dried by evaporation in a temperature gradient. Poly(acrylamide), poly(N-isopropylacrylamide), and poly(N-isopropylacrylamide-co-1-vinylimidazole) hydrogel particles with a diameter from 30 to 300 nm were detected and characterized by dynamic light scattering technique. The solvent, temperature, pH, and ionic sensitivities of the nanogels were studied.
    Type: Grant
    Filed: August 14, 2002
    Date of Patent: May 17, 2011
    Assignee: Polytechnic Institute of New York University
    Inventors: Sergey Kazakov, Marian Kaholek, Kalle Levon
  • Patent number: 7883648
    Abstract: Lipobeads (liposome-encapsulated hydrogels) combine properties of hydrogels and liposomes to create systems that are sensitive to environmental conditions and respond to changes in those conditions in a fast time scale. Lipobeads may be produced by polymerizing anchored or unanchored hydrogels within liposomes or by mixing anchored or unanchored hydrogels with liposomes. Giant lipobeads may be produced by shrinking unanchored nanogels in lipobeads and fusing the resulting lipobead aggregates, long-term aging of anchored or unanchored lipobeads, or mixing anchored or unanchored aggregated nanogels with liposomes. Poly(acrylamide), poly(N-isopropylacrylamide), and poly(N-isopropylacrylamide-co-1-vinylimidazole) lipobeads were produced and characterized.
    Type: Grant
    Filed: November 16, 2009
    Date of Patent: February 8, 2011
    Assignee: Polytechnic Institute of New York University
    Inventors: Sergey Kazakov, Marian Kaholek, Kalle Levon
  • Patent number: 7875310
    Abstract: Methods for preparing microparticles having reduced residual solvent levels. Microparticles are contacted with a non-aqueous washing system to reduce the level of residual solvent in the microparticles. Preferred non-aqueous washing systems include 100% ethanol and a blend of ethanol and heptane. A solvent blend of a hardening solvent and a washing solvent can be used to harden and wash microparticles in a single step, thereby eliminating the need for a post-hardening wash step.
    Type: Grant
    Filed: March 20, 2009
    Date of Patent: January 25, 2011
    Assignee: Alkermes, Inc.
    Inventors: Michael E. Rickey, J. Michael Ramstack, Rajesh Kumar
  • Patent number: 7838037
    Abstract: The present invention provides methods for microencapsulation of active ingredients for topical application, whereby double-layer and triple-layer microcapsules are obtained. The microcapsules protect the active ingredients, maintain their original activity throughout processing, formulation and storage, and enable controlled release of the active ingredient only upon application onto the skin.
    Type: Grant
    Filed: August 22, 2005
    Date of Patent: November 23, 2010
    Assignee: Tagra Biotechnologies Ltd.
    Inventors: Emma Kvitnitsky, Yury Shapiro, Olga Privalov, Irena Oleinik, Igor Polisher
  • Patent number: 7833578
    Abstract: A composition and a method for fabricating microcapsules encapsulating phase-change material by interfacial condensation polymerization are provided. In this composition and method, a surfactant and an organic solvent are not needed.
    Type: Grant
    Filed: March 12, 2008
    Date of Patent: November 16, 2010
    Assignee: Taiwan Textile Research Institute
    Inventors: Yen-Hsi Lin, Chi-Shu Wei
  • Patent number: 7807076
    Abstract: An improved process for the preparation of microcapsules consisting essentially of a wall material and a core material in condensing a melamine-formaldehyde precondensate and/or methyl ethers thereof in an aqueous dispersion of a water-insoluble core material and in the presence of an acrylic acid/acrylamide copolymer at acidic pH and at a temperature in the range of from 20° to 100° C., and hardening thereafter the melamine-formaldehyde precondensate to form the walls of the microcapsules at an elevated temperature, wherein the core material is dispersed in the precondensate/copolymer solution without initial partial condensation of the precondensate and copolymer and wherein the hydrophobe point of the precondensate and/or its methyl esters is less than 90° C., as well as microcapsules, paper and pressure-sensitive recording material comprising such microcapsules.
    Type: Grant
    Filed: October 17, 2002
    Date of Patent: October 5, 2010
    Assignee: Ciba Specialty Chemicals Corp.
    Inventors: Ann Hunt, Robert Montgomery O'Neil
  • Patent number: 7776240
    Abstract: Injectable hydrogel microspheres are prepared by forming an emulsion where hydrogel precursors are in a disperse aqueous phase and polymerizing the hydrogel precursors. In a preferred case, the hydrogel precursors are poly(ethylene glycol) diacrylate and N-isopropylacrylamide and the continuous phase of the emulsion is an aqueous solution of dextran and a dextran solubility reducer. The microspheres will load protein, e.g., cytokines, from aqueous solution.
    Type: Grant
    Filed: December 4, 2003
    Date of Patent: August 17, 2010
    Assignee: Cornell Research Foundation, Inc.
    Inventors: Chih-Chang Chu, Xian-Zheng Zhang, Da-Qing Wu
  • Publication number: 20100166876
    Abstract: A process is described for loading hydrophilic polymer particles with a water-insoluble solvent-soluble drug. The particles are preferably embolic agents. The method provides particles having little or no drug at the surface and in a surface layer, whereby the burst effect is minimised. The drug is precipitated in the core of the particle, leading to extended release. The drug is, for instance, paclitaxel, rapamycin, dexamethasone or ibuprofen.
    Type: Application
    Filed: February 9, 2007
    Publication date: July 1, 2010
    Applicant: BIOCOMPATIBLES UK LIMITED
    Inventors: Andrew Lennard Lewis, Yiqing Tang, Maria Victoria Gonzalez Fajardo
  • Publication number: 20100112123
    Abstract: In some embodiments there is a sweetener composition including (a) a co-crystallized/precipitated complex of cyclodextrin and sucralose; and (b) an encapsulant comprising a polymer.
    Type: Application
    Filed: January 7, 2010
    Publication date: May 6, 2010
    Applicant: Cadbury Adams USA LLC
    Inventors: Navroz Boghani, Petros Gebreselassie
  • Patent number: 7691296
    Abstract: The present invention relates to a method for stabilizing enzyme and water- and oil-soluble active components using polyol/polymer microcapsules, and to a cosmetic composition containing the enzyme and the microcapsules. More particularly, the present invention relates to polyol/polymer microcapsules which effectively stabilize the enzyme and active components, which are unstable in the formulations, through increasing the solubility thereof in hydrophobic polymer by using polyol, and to a method for preparing the polyol/polymer microcapsules.
    Type: Grant
    Filed: November 20, 2003
    Date of Patent: April 6, 2010
    Assignee: Amorepacific Corporation
    Inventors: Hee Kyung Ju, Jin Woong Kim, So Mi Lee, Sang Hoon Han, Ih Seop Chang
  • Patent number: 7629394
    Abstract: The present invention describes a process of preparing microcapsules in a UV curable water immiscible phase. The microcapsules formed according to the invention contain an aqueous phase core. The process comprises dispersing a water soluble or dispersible core material along with at least one wall forming prepolymer and a polycondensation polymerization catalyst into an aqueous solution. The aqueous phase is then dispersed into the water immiscible phase comprising UV curable monomers or oligomers forming droplets of the aqueous phase solution in the water immiscible phase. Polycondensation of the prepolymers is initiated to form polymeric wall material or microcapsules at or near the interface of the water immiscible solvent and droplets of aqueous phase solution. Following capsule formation, a UV initiator is dispersed in the water immiscible phase. The UV curable dispersion containing aqueous microcapsules can be coated on a substrate.
    Type: Grant
    Filed: February 21, 2006
    Date of Patent: December 8, 2009
    Assignee: Appleton Papers Inc.
    Inventor: Nianxi Yan
  • Patent number: 7618565
    Abstract: Lipobeads (liposome-encapsulated hydrogels) combine properties of hydrogels and liposomes to create systems that are sensitive to environmental conditions and respond to changes in those conditions in a fast time scale. Lipobeads may be produced by polymerizing anchored or unanchored hydrogels within liposomes or by mixing anchored or unanchored hydrogels with liposomes. Giant lipobeads may be produced by shrinking unanchored nanogels in lipobeads and fusing the resulting lipobead aggregates, long-term aging of anchored or unanchored lipobeads, or mixing anchored or unanchored aggregated nanogels with liposomes. Poly(acrylamide), poly(N-isopropylacrylamide), and poly(N-isopropylacrylamide-co-1-vinylimidazole) lipobeads were produced and characterized.
    Type: Grant
    Filed: August 14, 2002
    Date of Patent: November 17, 2009
    Assignee: Polytechnic Institute of New York University
    Inventors: Sergey Kazakov, Marian Kaholek, Kalle Levon
  • Patent number: 7588780
    Abstract: Embolic polymer particles are described.
    Type: Grant
    Filed: August 9, 2002
    Date of Patent: September 15, 2009
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: Marcia Buiser, Marc Bellisario, David Knapp, Stephan Mangin, Janel Lanphere
  • Publication number: 20090191276
    Abstract: Colloidosomes having tunable properties, methods for making the same, and applications thereof are described. Colloidosomes described herein are responsive to certain external stimulus to alter one or more properties of the colloidosome. Methods for making colloidosomes include forming a shell of colloidal particles on a core material where the colloidal particles and the core material have attractive interactions.
    Type: Application
    Filed: January 24, 2008
    Publication date: July 30, 2009
    Applicant: Fellows and President of Harvard University
    Inventors: Jin W. Kim, David A. Weltz
  • Patent number: 7524530
    Abstract: Methods for preparing microparticles having reduced residual solvent levels. Microparticles are contacted with a non-aqueous washing system to reduce the level of residual solvent in the microparticles. Preferred non-aqueous washing systems include 100% ethanol and a blend of ethanol and heptane. A solvent blend of a hardening solvent and a washing solvent can be used to harden and wash microparticles in a single step, thereby eliminating the need for a post-hardening wash step.
    Type: Grant
    Filed: April 19, 2007
    Date of Patent: April 28, 2009
    Assignee: Alkermes, Inc.
    Inventors: Michael E. Rickey, J. Michael Ramstack, Rajesh Kumar
  • Patent number: 7442410
    Abstract: A process for the microencapsulation of phase transitional paraffin compounds is described. Polypropylene glycols with the average molecule weight over 400 were used as the surface tension modifiers for emulsifying the paraffin compounds. Polyisocyanates capable of being dissolved in the phase change materials were employed to promote the deposition of melamine, partially methylolated melamine and the precondensate of melamine-formaldehyde onto the hydrophobic droplets for the microencapsulation. The prepared emulsion of microencapsulated phase change materials was successfully coated on textile fabrics and the coated products showed improved thermal regulation function.
    Type: Grant
    Filed: December 24, 2002
    Date of Patent: October 28, 2008
    Assignee: Nano-Sports Technologies Ltd.
    Inventors: Jianwei Xing, Yi Li, Edward Newton