Encapsulating Normally Liquid Material Patents (Class 264/4)
  • Patent number: 11413071
    Abstract: Disclosed are various embodiments for forming spinal rod members for use in pedicle screw systems for spinal fixation surgery and systems. A system can include a pedicle screw having a pedicle screw head and a pedicle screw shaft, the pedicle screw head comprising an aperture for receiving and retaining a spinal rod member relative to the pedicle screw. The spinal rod member can include an elongated tubular membrane having a flexible body and a spinal rod body formed of a compound, where the spinal rod body is formed by insertion of a liquid compound into the elongated tubular membrane and a hardening of the liquid compound or other similar process for conversion of the flexible rod to a rigid rod. The pedicle screw head can include a channel configured to receive and retain the spinal rod member.
    Type: Grant
    Filed: April 11, 2019
    Date of Patent: August 16, 2022
    Assignee: WONDERHEALTH LLC
    Inventor: Kenneth Hill
  • Patent number: 11344502
    Abstract: Disclosed are controlled release particles including: (a) a core including at least one vitamin which is oil-soluble or oil-dispersible; and (b) a wall at least partially surrounding the core, wherein the controlled release particles are produced by reacting (i) a first composition including a hydrophobic oil, the at least one vitamin, an anti-oxidant and a wax with (ii) a second composition including a water soluble emulsifier, a corn protein and a solvent to form an intermediate product, which is mixed with (iii) a third composition including a cellulosic polymer in water, and dehydrated to provide the controlled release particles. A method for preparing the particles and compositions containing the particles are also disclosed.
    Type: Grant
    Filed: February 27, 2019
    Date of Patent: May 31, 2022
    Assignee: TRUCAPSOL LLC
    Inventors: Jiten Odhavji Dihora, Caroline Rachel Multari
  • Patent number: 11154824
    Abstract: A method and apparatus for generating droplets with a high level of uniformity in liquid systems that present a low interfacial tension. This method and apparatus utilize the breakup of the dispersed phase in a controlled fashion by periodically varying the pressure that drives the fluids so as to successfully generate emulsions with a good control over the size. The method and apparatus can be used for the formation of simple emulsion or double emulsion where a larger droplet contains one or more smaller droplets.
    Type: Grant
    Filed: August 22, 2018
    Date of Patent: October 26, 2021
    Assignee: VERSITECH LIMITED
    Inventors: Ho Cheung Shum, Alban Sauret, Zida Li, Yang Song
  • Patent number: 11033497
    Abstract: Methods of making and resultant acidulent/carbohydrate agglomerates. The acidulent may be citric acid having particle sizes ranging from about 1 micron to 20 microns agglomerated with a soluble carbohydrate co-agglomerate to formulate the various acidulent/carbohydrate agglomerates. In certain embodiments, the carbohydrate co-agglomerate may be maltodextrin to formulate citric acid/maltodextrin agglomerates. These citric acid/maltodextrin agglomerates are shelf stable when dry, have improved flowability, compressibility, mixability; dissolve easily and quickly in water; and provide an easy ready-to-use formulation that is suitable for use in compounding various food and pharmaceutical products.
    Type: Grant
    Filed: August 24, 2017
    Date of Patent: June 15, 2021
    Assignee: The MBP Company LLC
    Inventors: Matthew M. Pearson, William Valentine, William K. Valentine
  • Patent number: 10934409
    Abstract: Inorganic infrared attenuation agent blends have been developed to improve the thermal insulation properties of polymeric foams such as polystyrene low density foams. The inorganic infrared attenuation agent blends can include two or more metal oxides such as silicon dioxide, manganese (IV) oxide, iron (III) oxide, magnesium oxide, bismuth (III) oxide, cobalt oxide, zirconium (IV) oxide, molybdenum (III) oxide, titanium oxide, and calcium oxide. In some preferred embodiments, the inorganic infrared attenuation agent blends can include four or more of these metal oxides.
    Type: Grant
    Filed: August 20, 2018
    Date of Patent: March 2, 2021
    Assignee: Owens Coming Intellectual Capital, LLC
    Inventors: Xiangmin Han, Nigel Ravenscroft, Jose Mendez-Andino, Chase J. Boudreaux, Yadollah Delaviz, John R. Green, Heather Alspaugh
  • Patent number: 10914991
    Abstract: Provided is a flexible cell unit and a method of manufacturing the same. The cell unit includes first and second substrates separated by a controlled distance maintained by spacers, filled with an electro-optic material and enclosed by a border seal. The method includes providing two sheets to form the first and second substrates, where at least one of the sheets is flexible, depositing an electro-optic material on at least one substrate, and roll-filling the cell by using one or more lamination rollers to pair the first and second substrates to within the controlled distance of each other and filling the controlled distance with the electro-optic material.
    Type: Grant
    Filed: August 30, 2019
    Date of Patent: February 9, 2021
    Assignee: ALPHAMICRON INCORPORATED
    Inventors: Roy E. Miller, IV, Christine Baker, Ludmila Sukhomlinova, Eui-Yeul Park, William Ryan, Bahman Taheri, Paul Luchette
  • Patent number: 10874135
    Abstract: An apparatus for manufacturing a flavor capsule of tobacco according to an embodiment of the present disclosure may comprise: a membrane tank for storing a membrane; a flavored liquid tank for storing a flavored liquid; and a nozzle to which the membrane is supplied from the membrane tank, to which the flavored liquid is supplied from the flavored liquid tank, and through which the flavored liquid is discharged while being enveloped in the membrane, so as to form the initial shape of a flavor capsule, wherein the membrane tank is equipped with a temperature adjustment unit for lowering the temperature of the membrane tank over time in order to preserve the viscosity of the membrane.
    Type: Grant
    Filed: April 4, 2016
    Date of Patent: December 29, 2020
    Assignee: KT & G Corporation
    Inventors: Ick Joong Kim, Jung Seop Hwang, Chang Gook Lee, Mi Jeong Bang, Jae Gon Lee, Han Joo Chung
  • Patent number: 10835486
    Abstract: Biocompatible hydrogel capsules encapsulating mammalian cells having a diameter of greater than 1 mm, and optionally a cell free core, are disclosed which have reduced fibrotic overgrowth after implantation in a subject. Methods of treating a disease in a subject are also disclosed that involve administering a therapeutically effective amount of the disclosed encapsulated cells to the subject.
    Type: Grant
    Filed: December 15, 2016
    Date of Patent: November 17, 2020
    Assignees: Massachusetts Institute of Technology, The Children's Medical Center Corporation
    Inventors: Minglin Ma, Daniel G. Anderson, Robert S. Langer, Omid Veiseh, Arturo Jose Vegas, Joshua Charles Doloff, Delai Chen, Christian J. Kastrup
  • Patent number: 10823899
    Abstract: A liquid crystal light-adjusting film includes a polymer material substrate and a plurality of elliptical crystal cells. The polymer material substrate has a light incident surface and a light exiting surface opposite to each other. A direction from the light incident surface to the light exiting surface is a thickness direction of the polymer material substrate. The elliptical crystal cells are disposed in the polymer material substrate. A long axis direction of each of the elliptical crystal cells is arranged along a first direction perpendicular to the thickness direction, and each of the elliptical crystal cells comprises a plurality of liquid crystal molecules. A manufacturing method of the liquid crystal light-adjusting film and a backlight module using the liquid crystal light-adjusting film are also provided.
    Type: Grant
    Filed: March 22, 2019
    Date of Patent: November 3, 2020
    Assignee: Coretronic Corporation
    Inventors: Hsiung-Chun Hsu, Chih-Jen Tsang, Ping-Yeng Chen, Chong-Yang Fang
  • Patent number: 10786454
    Abstract: An aerosol liposome of a marine extract and a method of producing the same are introduced. The marine extract is extracted from cell membranes of marine processing streams, including phosphatidylserine (PS), phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylinositol (PI), and lysophosphatidylcholine (LysoPC), further including at least phosphatidylserine (PS). The aerosol liposome is of a particle diameter of less than 2,000 nm. The surface of the aerosol liposome carries phosphatidylserine (PS) molecules. The aerosol liposome of a marine extract, thus provided, is simple and stable and can be absorbed through the mouth, nose, upper respiratory tract, and epidermis and engulfed by macrophages therein to quickly alleviate or regulate systematic inflammatory responses and prevent inflammation-related diseases.
    Type: Grant
    Filed: October 20, 2016
    Date of Patent: September 29, 2020
    Assignee: FISHERIES RESEARCH INSTITUTE, COUNCIL OF AGRICULTURE
    Inventors: Yi-Feng Kao, Yi-Chen Chen, Chwen-Herng Wu
  • Patent number: 10655106
    Abstract: Disclosed herein are methods, compositions, kits, and agents useful for inducing ? cell maturation, and isolated populations of SC-? cells for use in various applications, such as cell therapy.
    Type: Grant
    Filed: July 23, 2018
    Date of Patent: May 19, 2020
    Assignee: President and Fellows of Harvard College
    Inventors: Quinn P. Peterson, Felicia J. Pagliuca, Douglas A. Melton, Jeffrey R. Millman, Michael Saris Segel, Mads Gurtler
  • Patent number: 10653134
    Abstract: Disclosed herein is a stable, encapsulated reactive amine composition, having a particle size about 100 microns or less comprising; water soluble amine; polymeric surfactant/stabilizer; polyisocynate; and fumed silica; wherein, the reactive amine is released from the encapsulated amine in aqueous and non-aqueous environment, for use in industries such as painting, cosmetics, paper, lubricants, printing, plastics, petrochemicals etc. Further, the invention provides process for the preparation of stable microcapsule composition, without converting the water soluble amine into its salt or adduct and its characterization thereof.
    Type: Grant
    Filed: November 10, 2015
    Date of Patent: May 19, 2020
    Assignee: Council of Scientific and Industrial Research
    Inventors: Parshuram Gajanan Shukla, Arun Savalaram Jadhav
  • Patent number: 10639607
    Abstract: The system can include: a conduit having a first dimension with an inlet and outlet; an extruder having an inlet and an outlet located within the conduit, an extruder orifice having a second dimension that is smaller than the first dimension; a carrier fluid reservoir coupled with the conduit inlet; an extruder reservoir coupled with the extruder inlet; and a particle collector fluidly coupled with the conduit outlet, wherein the particle collector has a collector inlet with a first temperature and a collector outlet with a second temperature. The method can include flowing carrier fluid through the extrudate conduit; extruding wax with the extruder into the carrier fluid that is flowing through the extrudate conduit such that the extrudate separates into extrudate segments separated from each other by carrier fluid segments; and flowing the extrudate into the particle collector so as to form wax particles.
    Type: Grant
    Filed: June 12, 2018
    Date of Patent: May 5, 2020
    Assignee: MATRALIX PTE LTD
    Inventors: Siew Keong Loke, Kit Ying Soo
  • Patent number: 10590372
    Abstract: This disclosure relates to a multi-stage method and apparatus for purifying extracellular vesicles using an aqueous two-phase system, in which extracellular vesicles mixed and contaminated with proteins can be isolated and purified in a large amount at high purity within a short time through a multi-stage purification process using an aqueous two-phase system, thereby removing 95% or more of proteins and obtaining high-purity extracellular vesicles, resulting in very high processing efficiency compared to conventional techniques. In particular, the method of the disclosure does not require an expensive device or material such as an ultracentrifuge or an antibody, and can be performed at low cost and is thus economical and highly competitive. Furthermore, the extracellular vesicles thus isolated and purified can be employed in analysis methods such as RT-PCR or western blot, and can be utilized for research fields and disease diagnosis using the same.
    Type: Grant
    Filed: March 3, 2016
    Date of Patent: March 17, 2020
    Assignee: POSTECH ACADEMY-INDUSTRY FOUNDATION
    Inventors: Jae Sung Park, Hyun Woo Shin
  • Patent number: 10544314
    Abstract: A composition for solar cell electrodes and a solar cell electrode fabricated using the composition, the composition including a conductive powder; a glass frit; an organic vehicle; and a surface tension modifier, wherein the surface tension modifier has a surface tension of about 40 mN/m to about 65 mN/m, and the composition has a thixotropic index (TI) of about 3 to about 10 as represented by Equation 1: TI=(viscosity at 10 rpm/viscosity at 100 rpm),??[Equation 1] in Equation 1, the thixotropic index is calculated using viscosity values of the composition measured at 10 rpm and 100 rpm and at 23° C. with a No. 14 Spindle using a rotary viscometer.
    Type: Grant
    Filed: December 31, 2014
    Date of Patent: January 28, 2020
    Assignee: SAMSUNG SDI CO., LTD.
    Inventors: Tae Joon Kim, Sang Hee Park, Myung Sung Jung, Koon Ho Kim, Hyun Jin Ha
  • Patent number: 10512611
    Abstract: Capsular dosage forms containing polyunsaturated fatty acid (PUFA) compositions are provided herein. In certain embodiments, unit dosage forms comprising a plurality of millicapsules containing a PUFA composition therein are provided as well as their methods of use and manufacture. In certain embodiments, capsular dosage forms are provided herein that include a unit dosage form comprising a plurality of millicapsules containing a polyunsaturated free fatty acid substantially in free acid form. In some embodiments, the PUFA composition is Epanova®.
    Type: Grant
    Filed: February 19, 2016
    Date of Patent: December 24, 2019
    Assignee: Omthera Pharmaceuticals Inc.
    Inventors: Hironori Kubota, Etienne Thierry Charles Rogeau, Tohru Amemiya, Julien Georges Meissonnier, Anders Gillis Holmén, Andreas Rådevik, Hans Carlsson, Bengt Staffan Schantz
  • Patent number: 10279523
    Abstract: A microbubble creating method using a forming machine for creating microbubbles by: installed a microbubble generating member in a mold, feed screw or barrel for enabling a perforated tip of the microbubble generating member to be surrounded by the applied fluid polymer so that when a high pressure high temperature gas is delivered through the perforated tip of the microbubble generating member, microbubbles are created with well mixed with the fluid polymer, and the expected foamed polymer product is thus obtained after cooling.
    Type: Grant
    Filed: October 1, 2015
    Date of Patent: May 7, 2019
    Assignee: EVERFOCUS INTERNATIONAL CO., LTD.
    Inventors: Wei-Chih Liao, Cristina Chang
  • Patent number: 10239244
    Abstract: A microbubble creating method using a forming machine for creating microbubbles by: installed a microbubble generating member in a mold, feed screw or barrel for enabling a perforated tip of the microbubble generating member to be surrounded by the applied fluid polymer so that when a high pressure high temperature gas is delivered through the perforated tip of the microbubble generating member, microbubbles are created with well mixed with the fluid polymer, and the expected foamed polymer product is thus obtained after cooling.
    Type: Grant
    Filed: June 7, 2018
    Date of Patent: March 26, 2019
    Assignee: Everfocus International Co., Ltd.
    Inventors: Wei-Chih Liao, Cristina Chang
  • Patent number: 10239243
    Abstract: A microbubble creating method using a forming machine for creating microbubbles by: installed a microbubble generating member in a mold, feed screw or barrel for enabling a perforated tip of the microbubble generating member to be surrounded by the applied fluid polymer so that when a high pressure high temperature gas is delivered through the perforated tip of the microbubble generating member, microbubbles are created with well mixed with the fluid polymer, and the expected foamed polymer product is thus obtained after cooling.
    Type: Grant
    Filed: June 7, 2018
    Date of Patent: March 26, 2019
    Assignee: Everfocus International Co., Ltd.
    Inventors: Wei-Chih Liao, Cristina Chang
  • Patent number: 10238141
    Abstract: A capsule forming apparatus comprising a plurality of outputs configured to output capsule materials, a tank for housing a first capsule material and being configured to supply the first capsule material to the outputs and at least one conduit being configured to convey a second capsule material to the outputs. A method for forming capsules is also described.
    Type: Grant
    Filed: July 27, 2012
    Date of Patent: March 26, 2019
    Assignee: BRITISH AMERICAN TOBACCO (INVESTMENTS) LIMITED
    Inventor: Robert Seon Whiffen
  • Patent number: 10194995
    Abstract: Systems and methods for registering and tracking multiple anatomical structures, e.g., multiple vertebrae, as a single functional unit for surgical procedures are disclosed herein. In some embodiments, the system can include a bone bridge for attaching a navigation marker to multiple vertebrae and for limiting or preventing movement between the multiple vertebrae. Various ways of attaching the bone bridge are disclosed, including fasteners that extend through gaps or throughholes formed in the bridge, bridges having a jaw portion that clamps the underlying bone, and bridges formed of adhesive or cement and directly attached to the bone. Various adjustment features are also disclosed, including joints that allow the position and/or orientation of the bridge to be adjusted in one or more degrees of freedom, and bridges that include telescoping portions or other features for adjusting a length of the bridge.
    Type: Grant
    Filed: December 12, 2016
    Date of Patent: February 5, 2019
    Assignee: Medos International Sarl
    Inventors: Masashi Neo, J. Riley Hawkins, Aniruddha Raina
  • Patent number: 10172791
    Abstract: Biomedical devices for implantation with decreased pericapsular fibrotic overgrowth are disclosed. The device includes biocompatible materials and has specific characteristics that allow the device to elicit less of a fibrotic reaction after implantation than the same device lacking one or more of these characteristic that are present on the device. Biocompatible hydrogel capsules encapsulating mammalian cells having a diameter of greater than 1 mm, and optionally a cell free core, are disclosed which have reduced fibrotic overgrowth after implantation in a subject. Methods of treating a disease in a subject are also disclosed that involve administering a therapeutically effective amount of the disclosed encapsulated cells to the subject.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: January 8, 2019
    Assignee: Massachusetts Institute of Technology
    Inventors: Minglin Ma, Daniel G. Anderson, Robert S. Langer, Omid Veiseh, Joshua Charles Doloff, Delai Chen, Christian J. Kastrup, Arturo Jose Vegas
  • Patent number: 10066105
    Abstract: A renewable material for releasing a self-healing agent includes a renewable polymeric substrate with capsules and a reactant dispersed in the renewable polymeric substrate. The capsules may be formed from a first renewable shell polymer and may enclose the renewable self-healing agent. The reactant may be suitable for reacting with the renewable self-healing agent to form a polymer.
    Type: Grant
    Filed: April 14, 2016
    Date of Patent: September 4, 2018
    Assignee: International Business Machines Corporation
    Inventors: Dylan J. Boday, Jason T. Wertz
  • Patent number: 9974745
    Abstract: Disclosed are novel methods for making cochleates and cochleate compositions that include introducing a cargo moiety to a liposome in the presence of a solvent. Also disclosed are cochleates and cochleate compositions that include an aggregation inhibitor, and optionally, a cargo moiety. Additionally, anhydrous cochleates that include a protonized cargo moiety, a divalent metal cation and a negatively charge lipid are disclosed. Methods of using the cochleate compositions of the invention, including methods of administration, are also disclosed.
    Type: Grant
    Filed: January 30, 2014
    Date of Patent: May 22, 2018
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Raphael J. Mannino, Susan Gould-Fogerite, Sara L. Krause-Elsmore, David Delmarre, Ruying Lu
  • Patent number: 9962335
    Abstract: An object is to provide a method of manufacturing a soft capsule that is enteric and excellent in formulation properties. An enteric soft capsule is manufactured by the following steps (a) and (b): (a) preparing an enteric capsule shell liquid comprising gelatin and low methoxyl pectin having a degree of amidation of 5 to 25%, and (b) encapsulating capsule fills using the enteric capsule shell liquid prepared in the step (a) by stamping. Preferably, the jelly strength of the gelatin is 160 to 300 Bloom, the degree of esterification of the low methoxy pectin is 20 to 40%, and the enteric capsule shell liquid comprises 30 to 35 parts by mass of the low methoxy pectin per 100 parts by mass of the gelatin.
    Type: Grant
    Filed: October 6, 2015
    Date of Patent: May 8, 2018
    Assignee: FUJI CAPSULE CO., LTD.
    Inventors: Kazuhiko Watanabe, Hiroaki Hasegawa, Nahonori Inaba, Yoshiyuki Shimokawa, Kenji Kato
  • Patent number: 9852918
    Abstract: An electronic device comprising a carrier having a mounting surface, at least one electronic chip mounted on the mounting surface, an encapsulant at least partially encapsulating the carrier and the at least one electronic chip, and a plurality of capsules in the encapsulant, wherein the capsules comprise a core comprising an additive and comprise a shell, in particular a crackable shell, enclosing the core.
    Type: Grant
    Filed: August 26, 2015
    Date of Patent: December 26, 2017
    Assignee: Infineon Technologies AG
    Inventors: Peh Hean Teh, Jagen Krishnan, Swee Kah Lee, Poh Cheng Lim, Joachim Mahler, Chew Theng Tai, Yik Yee Tan, Soon Lock Goh
  • Patent number: 9820947
    Abstract: An object is to provide a method of manufacturing a seamless soft capsule that is enteric and excellent in formulation properties. An enteric seamless soft capsule is manufactured by the following steps (a) and (b): (a) preparing an enteric capsule shell liquid comprising gelatin and low methoxy pectin having a degree of esterification of 0 to 40% and a degree of amidation of 0 to 25%, the enteric capsule shell liquid having a viscosity at 50° C. of 60 to 127 mPa·s; and (b) encapsulating capsule fills with the enteric capsule shell liquid prepared in the step (a) by dripping. Preferably, the jelly strength of the gelatin is 180 to 330 Bloom, an aqueous solution of the low methoxy pectin at a concentration of 2 mass % has a viscosity at 35° C. of 8 to 15 mPa·s, and the enteric capsule shell liquid comprises 10 to 20 parts by mass of the low methoxy pectin per 100 parts by mass of gelatin.
    Type: Grant
    Filed: October 6, 2015
    Date of Patent: November 21, 2017
    Assignee: FUJI CAPSULE CO., LTD.
    Inventors: Koji Masuda, Naoki Nishimura, Akihiko Hayano, Yoshiyuki Shimokawa, Kenji Kato
  • Patent number: 9820944
    Abstract: Methods of making and resultant acidulent/carbohydrate agglomerates. The acidulent may be citric acid having particle sizes ranging from about 1 micron to 20 microns agglomerated with a soluble carbohydrate co-agglomerate to formulate the various acidulent/carbohydrate agglomerates. In certain embodiments, the carbohydrate co-agglomerate may be maltodextrin to formulate citric acid/maltodextrin agglomerates. These citric acid/maltodextrin agglomerates are shelf stable when dry, have improved flowability, compressibility, mixability; dissolve easily and quickly in water; and provide an easy ready-to-use formulation that is suitable for use in compounding various food and pharmaceutical products.
    Type: Grant
    Filed: July 23, 2014
    Date of Patent: November 21, 2017
    Assignee: THE MBP COMPANY LLC
    Inventors: Matthew M. Pearson, William Valentine, William K. Valentine
  • Patent number: 9725684
    Abstract: A seamless capsule comprises at least one core and a shell layer. The capsule can further comprise an intermediate layer which surrounds the core(s) and is surrounded by the shell layer. The shell layer comprises a material selected from the group consisting of water-soluble polymers, water-dispersible polymer, hydrogels. The shell layer can further comprise a disintegration aid.
    Type: Grant
    Filed: February 25, 2011
    Date of Patent: August 8, 2017
    Assignee: Milliken & Company
    Inventors: Gregory E. Fernandes, Robert M. MacMeccan
  • Patent number: 9711821
    Abstract: The present invention provides a lithium secondary battery and the preparation thereof, more specifically a lithium secondary battery comprising an electrode assembly having a cathode, an anode, and a separator interposed between the cathode and the anode; and a non-aqueous electrolyte solution impregnated in the electrode assembly, wherein the separator further comprises a layer having a plurality of destroyed capsules dispersed therein, the layer being formed on at least one surface of the separator coming into contact with the cathode and the anode, and the destroyed capsules has a film formed from a binder polymer and inorganic particles dispersed therebetween. The lithium secondary battery of the present invention can be prepared without the separate introducing process of a non-aqueous electrolyte solution, and has a separator exhibiting improved mechanical property and safety.
    Type: Grant
    Filed: March 13, 2015
    Date of Patent: July 18, 2017
    Assignee: LG Chem, Ltd.
    Inventors: Chul-Haeng Lee, Doo Kyung Yang
  • Patent number: 9630848
    Abstract: The method of the present disclosure is directed towards the formation of a three-dimensional carbon structure and includes the steps of adding a radical initiator to an amount of carbon starting material, forming a mixture, placing the mixture in a mold, maintaining the mixture and the mold at an elevated temperature for a period of time to form a thermally cross-linked molded mixture and removing the thermally cross-linked molded mixture from the mold. The disclosure also includes a three-dimensional carbon structure, with that structure including a thermally cross-linked carbon base material in a predetermined formation.
    Type: Grant
    Filed: April 4, 2013
    Date of Patent: April 25, 2017
    Assignee: The Research Foundation for The State of New York
    Inventors: Balaji Sitharaman, Gaurav Lalwani
  • Patent number: 9616020
    Abstract: The invention provides delivery systems comprised of stabilized multilamellar vesicles, as well as compositions, methods of synthesis, and methods of use thereof. The stabilized multilamellar vesicles may comprise prophylactic, therapeutic and/or diagnostic agents.
    Type: Grant
    Filed: April 13, 2016
    Date of Patent: April 11, 2017
    Assignee: Massachusetts Institute of Technology
    Inventors: Darrell J. Irvine, Jaehyun Moon
  • Patent number: 9510609
    Abstract: The present invention is related to a seamless capsule which easily dissolves in the oral cavity etc. The present invention provides a seamless capsule comprising a capsule content solution, and a capsule shell enclosing the capsule content solution, wherein the capsule shell comprises a gelatin having a bloom value of 50 to 190 and wherein the seamless capsule has a capsule shell-dissolution time of 60 seconds or less when the dissolution time is determined by a disintegration test using water as a test solution.
    Type: Grant
    Filed: September 21, 2012
    Date of Patent: December 6, 2016
    Assignee: MORISHITA JINTAN CO., LTD.
    Inventors: Ryosei Kamaguchi, Osami Nakano, Hisaaki Hatanaka
  • Patent number: 9511336
    Abstract: The present invention relates to a method for producing beads comprising a material capable of gelation, said method comprising the steps of: (i) combining (a) a liquid composition comprising a material capable of gelation; and (b) a first hydrophobic phase; (ii) subjecting the liquid composition and the first hydrophobic phase, to means for emulsification in a first reactor by addition of external mechanical energy creating an emulsion comprising individual droplets comprising the material capable of gelation in the first hydrophobic phase (wherein the material capable of gelation provides a discontinuous phase and the first hydrophobic phase provides a continuous phase); (iii) stabilizing the droplets by transferring the emulsion from the first reactor to a stabilization reactor wherein the emulsion obtained in step (ii) is subjected to means for gelation in order to obtain gelation within 5 minutes or less, and the beads are formed.
    Type: Grant
    Filed: October 19, 2015
    Date of Patent: December 6, 2016
    Assignee: DPx Holdings B.V.
    Inventors: Allan Otto Fog Lihme, Marie Bendix Hansen, Rene Oehlenschlaeger Holte, Brian A. Larsen
  • Patent number: 9498411
    Abstract: The present invention relates to perfume-containing microcapsules having both an aqueous inner phase and an oily inner phase, which can be used in home or personal care products, as well as to the process for producing these microcapsules and the consumer products comprising them.
    Type: Grant
    Filed: June 3, 2014
    Date of Patent: November 22, 2016
    Assignee: Firmenich SA
    Inventors: Lahoussine Ouali, Marlène Jacquemond
  • Patent number: 9499719
    Abstract: A process allowing the encapsulation of a polymerization accelerator comprising the steps of: a) providing an reverse emulsion containing, in an oil phase, a water solution/dispersion containing the polymerization activator, the oil phase including a heat curable mixture of an isocyanate and a polyalkyldiene hydroxylated or polyol, b) pouring the reverse emulsion in a water phase to make a multiple emulsion water/oil/water, containing drops of activators as the internal water phase, and then, c) heating the multiple emulsion obtained in step b) at a temperature of between 50 and 95° C., in order to cure the polyisocyanate in polyurethane and obtain drops of activator enclosed in shells of polyurethane dispersed in water. The invention also relates to aqueous gelling systems comprising the encapsulated polymerization accelerator with water soluble or dispersable monomers and a polymerization initiator dispersed in said monomers, useful i.a.
    Type: Grant
    Filed: March 8, 2012
    Date of Patent: November 22, 2016
    Assignee: RHODIA OPERATIONS
    Inventors: Arnaud Cadix, Rabih Rached, Pierre Ardaud
  • Patent number: 9445994
    Abstract: The invention provides delivery systems comprised of stabilized multilamellar vesicles, as well as compositions, methods of synthesis, and methods of use thereof. The stabilized multilamellar vesicles comprise terminal-cysteine-bearing antigens or cysteine-modified antigens, at their surface and/or internally.
    Type: Grant
    Filed: June 17, 2015
    Date of Patent: September 20, 2016
    Assignee: Massachusetts Institute of Technology
    Inventors: Darrell J. Irvine, Jaehyun Moon
  • Patent number: 9402923
    Abstract: The present application discloses solid compositions for the oral administration of dyes, and diagnostic use thereof. Preferably, such diagnostic use is aimed at the diagnostic evaluation of the gastrointestinal tract.
    Type: Grant
    Filed: July 1, 2013
    Date of Patent: August 2, 2016
    Assignee: COSMO TECHNOLOGIES INC.
    Inventors: Luigi Moro, Mauro Severino Ajani, Roberto Villa, Giuseppe Celasco, Alessandro Repici
  • Patent number: 9402922
    Abstract: The present application discloses solid compositions for the oral administration of dyes, and diagnostic use thereof. Preferably, such diagnostic use is aimed at the diagnostic evaluation of the gastrointestinal tract.
    Type: Grant
    Filed: July 1, 2013
    Date of Patent: August 2, 2016
    Assignee: COSMO TECHNOLOGIES INC.
    Inventors: Luigi Moro, Mauro Severino Ajani, Roberto Villa, Giuseppe Celasco, Alessandro Repici
  • Patent number: 9387262
    Abstract: The present invention is related to a lipid composition comprising at least a first lipid component, at least a first helper lipid, and a shielding compound which is removable from the lipid composition under in vivo conditions.
    Type: Grant
    Filed: October 6, 2014
    Date of Patent: July 12, 2016
    Assignee: SILENCE THERAPEUTICS GMBH
    Inventors: Oliver Keil, Jorg Kaufmann
  • Patent number: 9339462
    Abstract: The invention provides delivery systems comprised of stabilized multilamellar vesicles, as well as compositions, methods of synthesis, and methods of use thereof. The stabilized multilamellar vesicles may comprise prophylactic, therapeutic and/or diagnostic agents.
    Type: Grant
    Filed: December 23, 2014
    Date of Patent: May 17, 2016
    Assignee: Massachusetts Institute of Technology
    Inventors: Darrell J. Irvine, Jaehyun Moon
  • Patent number: 9334422
    Abstract: The invention relates to a contact release capsule comprising a particle, a chemical payload, and a polymer coating, wherein the particle is impregnated with the chemical payload, and the chemical payload is held inside the particle by the polymer coating until the contact release capsule contacts a surface and a shearing force removes the polymer coating allowing the chemical payload to release outside the particle. The contact release capsule is useful in chemical mechanical planarization slurries. Particularly, the contact release capsule may comprise a glycine impregnated silica nanoparticle coated with a polymer, wherein the contact release capsule is dispersed in an aqueous solution and used in the copper chemical mechanical planarization process. Use of the contact release capsule in a slurry for copper chemical mechanical planarization may significantly improve planarization efficiency, decrease unwanted etching and corrosion, and improve dispersion stability.
    Type: Grant
    Filed: January 20, 2015
    Date of Patent: May 10, 2016
    Assignee: General Engineering & Research, L.L.C.
    Inventor: Robin Ihnfeldt
  • Patent number: 9322753
    Abstract: The present disclosure relates to a staining methodology employing a particle contrast agent composition capable of rapidly staining cells in a single step. The particle contrast agent composition can be comprised of a combination of one or more particle contrast agents and one or more permeabilizing agents, optionally including one or more fixing agents and other components. The particle contrast agent composition can include Crystal Violet, 5PD-Lytic, and Proclin 300.
    Type: Grant
    Filed: March 17, 2014
    Date of Patent: April 26, 2016
    Assignee: IRIS International, Inc.
    Inventor: Jack Cremins
  • Patent number: 9302794
    Abstract: A method produces and fills containers (1) made of thermoplastic plastic, in which an extruded plastic hose is inserted into an open mold having movable mold parts. The mold parts forming the container (1) are closed. The hose is expanded by a pressure gradient acting on the hose to form the container (1), preferably in the form of a bellows. The container is filled with filling material. The level of the filling material is raised by reducing container volume in the direction of the container opening. A container closure (5) for the container opening is formed from the hose by closing head jaws of the mold. In the region of the container closure (5), one section of the plastic hose remains unclosed to form a venting cannula (3). When the container volume is reduced, the level of the filling material is raised such that at least air is displaced from the container (1) through venting cannula (3). The venting cannula (3) is closed by closing auxiliary head jaws.
    Type: Grant
    Filed: June 30, 2011
    Date of Patent: April 5, 2016
    Inventor: Bernd Hansen
  • Patent number: 9291872
    Abstract: The present invention is directed to electrophoretic displays comprising microcups of a first shape and the microcups of a second shape, wherein each of the microcups of the first shape is surrounded by the microcups of the second shape, and the second shape is 90% or less of the first shape in area. The present electrophoretic displays comprise novel microcup designs, which may reduce the appearance of defects in the display images.
    Type: Grant
    Filed: February 6, 2013
    Date of Patent: March 22, 2016
    Assignee: E INK CALIFORNIA, LLC
    Inventors: Craig Lin, Robert A. Sprague
  • Patent number: 9079152
    Abstract: The invention provides a process for the preparation of essential oil microcapsules comprising dissolving a di- or polyisocyanate into an essential oil, emulsifying the resulting mixture in an aqueous solution containing a di- or polyamine, and or a di or polyhydroxy compound to effect encapsulation of said essential oil through interfacial polymerization, whereby there is formed a polyurea and/or polyurethane film around the essential oil droplets which film enhances the stability of said essential oil, reduces its evaporation rate and controls its release rate when applied to a substrate.
    Type: Grant
    Filed: May 6, 2004
    Date of Patent: July 14, 2015
    Assignee: BEN GURION UNIVERSITY OF THE NEGEV RESEARCH AND DEVELOPMENT AUTHORITY
    Inventors: Arie Markus, Charles Linder
  • Patent number: 9061268
    Abstract: The invention generally relates to the ultrasmall MOx nanoparticles that are made in a solvothermal method using water soluble inorganic ammonium salt precursors of the MOx and organic amines, and slow heating to generate uniform ultrasmall MOx nanoparticles of 5 nm or less, as well as methods to make and use same.
    Type: Grant
    Filed: June 9, 2011
    Date of Patent: June 23, 2015
    Assignee: William Marsh Rice University
    Inventors: Nikolaos Soultanidis, Michael S. Wong
  • Publication number: 20150115487
    Abstract: Encapsulated solids are made by first encapsulating precursor materials in a polymer shell. The precursors are some combination of solids, liquids, gases, and/or gels. The precursors are then transformed into solids by emplacement of the capsule in an environment where gas or fluid transport into or out of the polymer shell causes transformation into solids.
    Type: Application
    Filed: October 29, 2013
    Publication date: April 30, 2015
    Applicant: Lawrence Livermore National Security, LLC
    Inventors: William L. Bourcier, III, Roger D. Aines, Sarah E. Baker, Eric B. Duoss, Amitesh Maiti, Jeffery J. Roberts, Christopher M. Spadaccini, Joshuah K. Stolaroff, John J. Vericella, Jennifer A. Lewis, James O. Hardin, IV, William C. Floyd, III
  • Patent number: 8992196
    Abstract: A seamless capsule manufacturing apparatus (1) manufactures a seamless capsule by means of nozzles (2a-2d). A core liquid (5) and a coating liquid (6) are supplied to each of the nozzles (2a-2d) from pumps (16, 18) through distributors (21, 22). The distributors (21, 22) and the nozzles (2a-2d) are connected to each other by core liquid distributing tubes (23a-23d) and coating liquid distributing tubes (25a-25d), and each of the core liquid distributing tubes (23a-23d) and each of the coating liquid distributing tubes (25a-25d) have the same length. A vibrator (24) is mounted to the distributor (21), and the core liquid (5) is supplied to the nozzles (2a-2d) while being vibrated. Each of the distributors (21, 22) is provided with an air vent device (35), and air vent is performed appropriately.
    Type: Grant
    Filed: October 9, 2009
    Date of Patent: March 31, 2015
    Assignee: Freund Corporation
    Inventors: Masayuki Ikeda, Hiroshi Nagao
  • Publication number: 20150086613
    Abstract: Disclosed herein are novel lipids and liposomal compositions prepared using such compounds and related methods of neutralizing or otherwise modifying such liposomal compositions. The lipids described herein are useful for example, as liposomal vehicles to facilitate the delivery of encapsulated polynucleotides to target cells and the subsequent transfection of such target cells. In certain embodiments, one or more of the compounds that comprise the liposomal delivery vehicle may be neutralized or further modified such that the properties of the liposomal delivery vehicle are modified.
    Type: Application
    Filed: March 29, 2013
    Publication date: March 26, 2015
    Inventors: Frank DeRosa, Braydon Charles Guild, Michael Heartlein