Abstract: The disclosed technology relates to a formulation for a unit does cleansing product without the use of a film package, which contains a basic cleansing composition and a structurant comprising C6-C30 fatty acid or mixtures thereof and at least one water soluble polymer or water dispersible polymer.

Abstract: Disclosed are various embodiments for forming spinal rod members for use in pedicle screw systems for spinal fixation surgery and systems. A system can include a pedicle screw having a pedicle screw head and a pedicle screw shaft, the pedicle screw head comprising an aperture for receiving and retaining a spinal rod member relative to the pedicle screw. The spinal rod member can include an elongated tubular membrane having a flexible body and a spinal rod body formed of a compound, where the spinal rod body is formed by insertion of a liquid compound into the elongated tubular membrane and a hardening of the liquid compound or other similar process for conversion of the flexible rod to a rigid rod. The pedicle screw head can include a channel configured to receive and retain the spinal rod member.

Abstract: Disclosed are controlled release particles including: (a) a core including at least one vitamin which is oil-soluble or oil-dispersible; and (b) a wall at least partially surrounding the core, wherein the controlled release particles are produced by reacting (i) a first composition including a hydrophobic oil, the at least one vitamin, an anti-oxidant and a wax with (ii) a second composition including a water soluble emulsifier, a corn protein and a solvent to form an intermediate product, which is mixed with (iii) a third composition including a cellulosic polymer in water, and dehydrated to provide the controlled release particles. A method for preparing the particles and compositions containing the particles are also disclosed.

Abstract: A method and apparatus for generating droplets with a high level of uniformity in liquid systems that present a low interfacial tension. This method and apparatus utilize the breakup of the dispersed phase in a controlled fashion by periodically varying the pressure that drives the fluids so as to successfully generate emulsions with a good control over the size. The method and apparatus can be used for the formation of simple emulsion or double emulsion where a larger droplet contains one or more smaller droplets.

Abstract: Methods of making and resultant acidulent/carbohydrate agglomerates. The acidulent may be citric acid having particle sizes ranging from about 1 micron to 20 microns agglomerated with a soluble carbohydrate co-agglomerate to formulate the various acidulent/carbohydrate agglomerates. In certain embodiments, the carbohydrate co-agglomerate may be maltodextrin to formulate citric acid/maltodextrin agglomerates. These citric acid/maltodextrin agglomerates are shelf stable when dry, have improved flowability, compressibility, mixability; dissolve easily and quickly in water; and provide an easy ready-to-use formulation that is suitable for use in compounding various food and pharmaceutical products.

Abstract: Inorganic infrared attenuation agent blends have been developed to improve the thermal insulation properties of polymeric foams such as polystyrene low density foams. The inorganic infrared attenuation agent blends can include two or more metal oxides such as silicon dioxide, manganese (IV) oxide, iron (III) oxide, magnesium oxide, bismuth (III) oxide, cobalt oxide, zirconium (IV) oxide, molybdenum (III) oxide, titanium oxide, and calcium oxide. In some preferred embodiments, the inorganic infrared attenuation agent blends can include four or more of these metal oxides.

Abstract: Provided is a flexible cell unit and a method of manufacturing the same. The cell unit includes first and second substrates separated by a controlled distance maintained by spacers, filled with an electro-optic material and enclosed by a border seal. The method includes providing two sheets to form the first and second substrates, where at least one of the sheets is flexible, depositing an electro-optic material on at least one substrate, and roll-filling the cell by using one or more lamination rollers to pair the first and second substrates to within the controlled distance of each other and filling the controlled distance with the electro-optic material.

Abstract: An apparatus for manufacturing a flavor capsule of tobacco according to an embodiment of the present disclosure may comprise: a membrane tank for storing a membrane; a flavored liquid tank for storing a flavored liquid; and a nozzle to which the membrane is supplied from the membrane tank, to which the flavored liquid is supplied from the flavored liquid tank, and through which the flavored liquid is discharged while being enveloped in the membrane, so as to form the initial shape of a flavor capsule, wherein the membrane tank is equipped with a temperature adjustment unit for lowering the temperature of the membrane tank over time in order to preserve the viscosity of the membrane.

Abstract: Biocompatible hydrogel capsules encapsulating mammalian cells having a diameter of greater than 1 mm, and optionally a cell free core, are disclosed which have reduced fibrotic overgrowth after implantation in a subject. Methods of treating a disease in a subject are also disclosed that involve administering a therapeutically effective amount of the disclosed encapsulated cells to the subject.

Abstract: A liquid crystal light-adjusting film includes a polymer material substrate and a plurality of elliptical crystal cells. The polymer material substrate has a light incident surface and a light exiting surface opposite to each other. A direction from the light incident surface to the light exiting surface is a thickness direction of the polymer material substrate. The elliptical crystal cells are disposed in the polymer material substrate. A long axis direction of each of the elliptical crystal cells is arranged along a first direction perpendicular to the thickness direction, and each of the elliptical crystal cells comprises a plurality of liquid crystal molecules. A manufacturing method of the liquid crystal light-adjusting film and a backlight module using the liquid crystal light-adjusting film are also provided.

Abstract: An aerosol liposome of a marine extract and a method of producing the same are introduced. The marine extract is extracted from cell membranes of marine processing streams, including phosphatidylserine (PS), phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylinositol (PI), and lysophosphatidylcholine (LysoPC), further including at least phosphatidylserine (PS). The aerosol liposome is of a particle diameter of less than 2,000 nm. The surface of the aerosol liposome carries phosphatidylserine (PS) molecules. The aerosol liposome of a marine extract, thus provided, is simple and stable and can be absorbed through the mouth, nose, upper respiratory tract, and epidermis and engulfed by macrophages therein to quickly alleviate or regulate systematic inflammatory responses and prevent inflammation-related diseases.

Abstract: Disclosed herein is a stable, encapsulated reactive amine composition, having a particle size about 100 microns or less comprising; water soluble amine; polymeric surfactant/stabilizer; polyisocynate; and fumed silica; wherein, the reactive amine is released from the encapsulated amine in aqueous and non-aqueous environment, for use in industries such as painting, cosmetics, paper, lubricants, printing, plastics, petrochemicals etc. Further, the invention provides process for the preparation of stable microcapsule composition, without converting the water soluble amine into its salt or adduct and its characterization thereof.

Abstract: Disclosed herein are methods, compositions, kits, and agents useful for inducing ? cell maturation, and isolated populations of SC-? cells for use in various applications, such as cell therapy.

Abstract: The system can include: a conduit having a first dimension with an inlet and outlet; an extruder having an inlet and an outlet located within the conduit, an extruder orifice having a second dimension that is smaller than the first dimension; a carrier fluid reservoir coupled with the conduit inlet; an extruder reservoir coupled with the extruder inlet; and a particle collector fluidly coupled with the conduit outlet, wherein the particle collector has a collector inlet with a first temperature and a collector outlet with a second temperature. The method can include flowing carrier fluid through the extrudate conduit; extruding wax with the extruder into the carrier fluid that is flowing through the extrudate conduit such that the extrudate separates into extrudate segments separated from each other by carrier fluid segments; and flowing the extrudate into the particle collector so as to form wax particles.

Abstract: This disclosure relates to a multi-stage method and apparatus for purifying extracellular vesicles using an aqueous two-phase system, in which extracellular vesicles mixed and contaminated with proteins can be isolated and purified in a large amount at high purity within a short time through a multi-stage purification process using an aqueous two-phase system, thereby removing 95% or more of proteins and obtaining high-purity extracellular vesicles, resulting in very high processing efficiency compared to conventional techniques. In particular, the method of the disclosure does not require an expensive device or material such as an ultracentrifuge or an antibody, and can be performed at low cost and is thus economical and highly competitive. Furthermore, the extracellular vesicles thus isolated and purified can be employed in analysis methods such as RT-PCR or western blot, and can be utilized for research fields and disease diagnosis using the same.

Abstract: A composition for solar cell electrodes and a solar cell electrode fabricated using the composition, the composition including a conductive powder; a glass frit; an organic vehicle; and a surface tension modifier, wherein the surface tension modifier has a surface tension of about 40 mN/m to about 65 mN/m, and the composition has a thixotropic index (TI) of about 3 to about 10 as represented by Equation 1: TI=(viscosity at 10 rpm/viscosity at 100 rpm),??[Equation 1] in Equation 1, the thixotropic index is calculated using viscosity values of the composition measured at 10 rpm and 100 rpm and at 23° C. with a No. 14 Spindle using a rotary viscometer.

Abstract: Capsular dosage forms containing polyunsaturated fatty acid (PUFA) compositions are provided herein. In certain embodiments, unit dosage forms comprising a plurality of millicapsules containing a PUFA composition therein are provided as well as their methods of use and manufacture. In certain embodiments, capsular dosage forms are provided herein that include a unit dosage form comprising a plurality of millicapsules containing a polyunsaturated free fatty acid substantially in free acid form. In some embodiments, the PUFA composition is Epanova®.

Abstract: A microbubble creating method using a forming machine for creating microbubbles by: installed a microbubble generating member in a mold, feed screw or barrel for enabling a perforated tip of the microbubble generating member to be surrounded by the applied fluid polymer so that when a high pressure high temperature gas is delivered through the perforated tip of the microbubble generating member, microbubbles are created with well mixed with the fluid polymer, and the expected foamed polymer product is thus obtained after cooling.

Abstract: A capsule forming apparatus comprising a plurality of outputs configured to output capsule materials, a tank for housing a first capsule material and being configured to supply the first capsule material to the outputs and at least one conduit being configured to convey a second capsule material to the outputs. A method for forming capsules is also described.

Abstract: A microbubble creating method using a forming machine for creating microbubbles by: installed a microbubble generating member in a mold, feed screw or barrel for enabling a perforated tip of the microbubble generating member to be surrounded by the applied fluid polymer so that when a high pressure high temperature gas is delivered through the perforated tip of the microbubble generating member, microbubbles are created with well mixed with the fluid polymer, and the expected foamed polymer product is thus obtained after cooling.

Abstract: A microbubble creating method using a forming machine for creating microbubbles by: installed a microbubble generating member in a mold, feed screw or barrel for enabling a perforated tip of the microbubble generating member to be surrounded by the applied fluid polymer so that when a high pressure high temperature gas is delivered through the perforated tip of the microbubble generating member, microbubbles are created with well mixed with the fluid polymer, and the expected foamed polymer product is thus obtained after cooling.

Abstract: Systems and methods for registering and tracking multiple anatomical structures, e.g., multiple vertebrae, as a single functional unit for surgical procedures are disclosed herein. In some embodiments, the system can include a bone bridge for attaching a navigation marker to multiple vertebrae and for limiting or preventing movement between the multiple vertebrae. Various ways of attaching the bone bridge are disclosed, including fasteners that extend through gaps or throughholes formed in the bridge, bridges having a jaw portion that clamps the underlying bone, and bridges formed of adhesive or cement and directly attached to the bone. Various adjustment features are also disclosed, including joints that allow the position and/or orientation of the bridge to be adjusted in one or more degrees of freedom, and bridges that include telescoping portions or other features for adjusting a length of the bridge.

Abstract: Biomedical devices for implantation with decreased pericapsular fibrotic overgrowth are disclosed. The device includes biocompatible materials and has specific characteristics that allow the device to elicit less of a fibrotic reaction after implantation than the same device lacking one or more of these characteristic that are present on the device. Biocompatible hydrogel capsules encapsulating mammalian cells having a diameter of greater than 1 mm, and optionally a cell free core, are disclosed which have reduced fibrotic overgrowth after implantation in a subject. Methods of treating a disease in a subject are also disclosed that involve administering a therapeutically effective amount of the disclosed encapsulated cells to the subject.

Abstract: A renewable material for releasing a self-healing agent includes a renewable polymeric substrate with capsules and a reactant dispersed in the renewable polymeric substrate. The capsules may be formed from a first renewable shell polymer and may enclose the renewable self-healing agent. The reactant may be suitable for reacting with the renewable self-healing agent to form a polymer.

Abstract: Disclosed are novel methods for making cochleates and cochleate compositions that include introducing a cargo moiety to a liposome in the presence of a solvent. Also disclosed are cochleates and cochleate compositions that include an aggregation inhibitor, and optionally, a cargo moiety. Additionally, anhydrous cochleates that include a protonized cargo moiety, a divalent metal cation and a negatively charge lipid are disclosed. Methods of using the cochleate compositions of the invention, including methods of administration, are also disclosed.

Abstract: An object is to provide a method of manufacturing a soft capsule that is enteric and excellent in formulation properties. An enteric soft capsule is manufactured by the following steps (a) and (b): (a) preparing an enteric capsule shell liquid comprising gelatin and low methoxyl pectin having a degree of amidation of 5 to 25%, and (b) encapsulating capsule fills using the enteric capsule shell liquid prepared in the step (a) by stamping. Preferably, the jelly strength of the gelatin is 160 to 300 Bloom, the degree of esterification of the low methoxy pectin is 20 to 40%, and the enteric capsule shell liquid comprises 30 to 35 parts by mass of the low methoxy pectin per 100 parts by mass of the gelatin.

Abstract: An electronic device comprising a carrier having a mounting surface, at least one electronic chip mounted on the mounting surface, an encapsulant at least partially encapsulating the carrier and the at least one electronic chip, and a plurality of capsules in the encapsulant, wherein the capsules comprise a core comprising an additive and comprise a shell, in particular a crackable shell, enclosing the core.

Abstract: An object is to provide a method of manufacturing a seamless soft capsule that is enteric and excellent in formulation properties. An enteric seamless soft capsule is manufactured by the following steps (a) and (b): (a) preparing an enteric capsule shell liquid comprising gelatin and low methoxy pectin having a degree of esterification of 0 to 40% and a degree of amidation of 0 to 25%, the enteric capsule shell liquid having a viscosity at 50° C. of 60 to 127 mPa·s; and (b) encapsulating capsule fills with the enteric capsule shell liquid prepared in the step (a) by dripping. Preferably, the jelly strength of the gelatin is 180 to 330 Bloom, an aqueous solution of the low methoxy pectin at a concentration of 2 mass % has a viscosity at 35° C. of 8 to 15 mPa·s, and the enteric capsule shell liquid comprises 10 to 20 parts by mass of the low methoxy pectin per 100 parts by mass of gelatin.

Abstract: Methods of making and resultant acidulent/carbohydrate agglomerates. The acidulent may be citric acid having particle sizes ranging from about 1 micron to 20 microns agglomerated with a soluble carbohydrate co-agglomerate to formulate the various acidulent/carbohydrate agglomerates. In certain embodiments, the carbohydrate co-agglomerate may be maltodextrin to formulate citric acid/maltodextrin agglomerates. These citric acid/maltodextrin agglomerates are shelf stable when dry, have improved flowability, compressibility, mixability; dissolve easily and quickly in water; and provide an easy ready-to-use formulation that is suitable for use in compounding various food and pharmaceutical products.

Abstract: A seamless capsule comprises at least one core and a shell layer. The capsule can further comprise an intermediate layer which surrounds the core(s) and is surrounded by the shell layer. The shell layer comprises a material selected from the group consisting of water-soluble polymers, water-dispersible polymer, hydrogels. The shell layer can further comprise a disintegration aid.

Abstract: The present invention provides a lithium secondary battery and the preparation thereof, more specifically a lithium secondary battery comprising an electrode assembly having a cathode, an anode, and a separator interposed between the cathode and the anode; and a non-aqueous electrolyte solution impregnated in the electrode assembly, wherein the separator further comprises a layer having a plurality of destroyed capsules dispersed therein, the layer being formed on at least one surface of the separator coming into contact with the cathode and the anode, and the destroyed capsules has a film formed from a binder polymer and inorganic particles dispersed therebetween. The lithium secondary battery of the present invention can be prepared without the separate introducing process of a non-aqueous electrolyte solution, and has a separator exhibiting improved mechanical property and safety.

Abstract: The method of the present disclosure is directed towards the formation of a three-dimensional carbon structure and includes the steps of adding a radical initiator to an amount of carbon starting material, forming a mixture, placing the mixture in a mold, maintaining the mixture and the mold at an elevated temperature for a period of time to form a thermally cross-linked molded mixture and removing the thermally cross-linked molded mixture from the mold. The disclosure also includes a three-dimensional carbon structure, with that structure including a thermally cross-linked carbon base material in a predetermined formation.

Abstract: The invention provides delivery systems comprised of stabilized multilamellar vesicles, as well as compositions, methods of synthesis, and methods of use thereof. The stabilized multilamellar vesicles may comprise prophylactic, therapeutic and/or diagnostic agents.

Abstract: The present invention is related to a seamless capsule which easily dissolves in the oral cavity etc. The present invention provides a seamless capsule comprising a capsule content solution, and a capsule shell enclosing the capsule content solution, wherein the capsule shell comprises a gelatin having a bloom value of 50 to 190 and wherein the seamless capsule has a capsule shell-dissolution time of 60 seconds or less when the dissolution time is determined by a disintegration test using water as a test solution.

Abstract: The present invention relates to a method for producing beads comprising a material capable of gelation, said method comprising the steps of: (i) combining (a) a liquid composition comprising a material capable of gelation; and (b) a first hydrophobic phase; (ii) subjecting the liquid composition and the first hydrophobic phase, to means for emulsification in a first reactor by addition of external mechanical energy creating an emulsion comprising individual droplets comprising the material capable of gelation in the first hydrophobic phase (wherein the material capable of gelation provides a discontinuous phase and the first hydrophobic phase provides a continuous phase); (iii) stabilizing the droplets by transferring the emulsion from the first reactor to a stabilization reactor wherein the emulsion obtained in step (ii) is subjected to means for gelation in order to obtain gelation within 5 minutes or less, and the beads are formed.

Abstract: The present invention relates to perfume-containing microcapsules having both an aqueous inner phase and an oily inner phase, which can be used in home or personal care products, as well as to the process for producing these microcapsules and the consumer products comprising them.

Abstract: A process allowing the encapsulation of a polymerization accelerator comprising the steps of: a) providing an reverse emulsion containing, in an oil phase, a water solution/dispersion containing the polymerization activator, the oil phase including a heat curable mixture of an isocyanate and a polyalkyldiene hydroxylated or polyol, b) pouring the reverse emulsion in a water phase to make a multiple emulsion water/oil/water, containing drops of activators as the internal water phase, and then, c) heating the multiple emulsion obtained in step b) at a temperature of between 50 and 95° C., in order to cure the polyisocyanate in polyurethane and obtain drops of activator enclosed in shells of polyurethane dispersed in water. The invention also relates to aqueous gelling systems comprising the encapsulated polymerization accelerator with water soluble or dispersable monomers and a polymerization initiator dispersed in said monomers, useful i.a.

Abstract: The invention provides delivery systems comprised of stabilized multilamellar vesicles, as well as compositions, methods of synthesis, and methods of use thereof. The stabilized multilamellar vesicles comprise terminal-cysteine-bearing antigens or cysteine-modified antigens, at their surface and/or internally.

Abstract: The present application discloses solid compositions for the oral administration of dyes, and diagnostic use thereof. Preferably, such diagnostic use is aimed at the diagnostic evaluation of the gastrointestinal tract.

Abstract: The present application discloses solid compositions for the oral administration of dyes, and diagnostic use thereof. Preferably, such diagnostic use is aimed at the diagnostic evaluation of the gastrointestinal tract.

Abstract: The present invention is related to a lipid composition comprising at least a first lipid component, at least a first helper lipid, and a shielding compound which is removable from the lipid composition under in vivo conditions.

Abstract: The invention provides delivery systems comprised of stabilized multilamellar vesicles, as well as compositions, methods of synthesis, and methods of use thereof. The stabilized multilamellar vesicles may comprise prophylactic, therapeutic and/or diagnostic agents.

Abstract: The invention relates to a contact release capsule comprising a particle, a chemical payload, and a polymer coating, wherein the particle is impregnated with the chemical payload, and the chemical payload is held inside the particle by the polymer coating until the contact release capsule contacts a surface and a shearing force removes the polymer coating allowing the chemical payload to release outside the particle. The contact release capsule is useful in chemical mechanical planarization slurries. Particularly, the contact release capsule may comprise a glycine impregnated silica nanoparticle coated with a polymer, wherein the contact release capsule is dispersed in an aqueous solution and used in the copper chemical mechanical planarization process. Use of the contact release capsule in a slurry for copper chemical mechanical planarization may significantly improve planarization efficiency, decrease unwanted etching and corrosion, and improve dispersion stability.

Abstract: The present disclosure relates to a staining methodology employing a particle contrast agent composition capable of rapidly staining cells in a single step. The particle contrast agent composition can be comprised of a combination of one or more particle contrast agents and one or more permeabilizing agents, optionally including one or more fixing agents and other components. The particle contrast agent composition can include Crystal Violet, 5PD-Lytic, and Proclin 300.

Abstract: A method produces and fills containers (1) made of thermoplastic plastic, in which an extruded plastic hose is inserted into an open mold having movable mold parts. The mold parts forming the container (1) are closed. The hose is expanded by a pressure gradient acting on the hose to form the container (1), preferably in the form of a bellows. The container is filled with filling material. The level of the filling material is raised by reducing container volume in the direction of the container opening. A container closure (5) for the container opening is formed from the hose by closing head jaws of the mold. In the region of the container closure (5), one section of the plastic hose remains unclosed to form a venting cannula (3). When the container volume is reduced, the level of the filling material is raised such that at least air is displaced from the container (1) through venting cannula (3). The venting cannula (3) is closed by closing auxiliary head jaws.

Abstract: The present invention is directed to electrophoretic displays comprising microcups of a first shape and the microcups of a second shape, wherein each of the microcups of the first shape is surrounded by the microcups of the second shape, and the second shape is 90% or less of the first shape in area. The present electrophoretic displays comprise novel microcup designs, which may reduce the appearance of defects in the display images.

Abstract: The invention provides a process for the preparation of essential oil microcapsules comprising dissolving a di- or polyisocyanate into an essential oil, emulsifying the resulting mixture in an aqueous solution containing a di- or polyamine, and or a di or polyhydroxy compound to effect encapsulation of said essential oil through interfacial polymerization, whereby there is formed a polyurea and/or polyurethane film around the essential oil droplets which film enhances the stability of said essential oil, reduces its evaporation rate and controls its release rate when applied to a substrate.

Abstract: The invention generally relates to the ultrasmall MOx nanoparticles that are made in a solvothermal method using water soluble inorganic ammonium salt precursors of the MOx and organic amines, and slow heating to generate uniform ultrasmall MOx nanoparticles of 5 nm or less, as well as methods to make and use same.

Abstract: Encapsulated solids are made by first encapsulating precursor materials in a polymer shell. The precursors are some combination of solids, liquids, gases, and/or gels. The precursors are then transformed into solids by emplacement of the capsule in an environment where gas or fluid transport into or out of the polymer shell causes transformation into solids.

Abstract: A seamless capsule manufacturing apparatus (1) manufactures a seamless capsule by means of nozzles (2a-2d). A core liquid (5) and a coating liquid (6) are supplied to each of the nozzles (2a-2d) from pumps (16, 18) through distributors (21, 22). The distributors (21, 22) and the nozzles (2a-2d) are connected to each other by core liquid distributing tubes (23a-23d) and coating liquid distributing tubes (25a-25d), and each of the core liquid distributing tubes (23a-23d) and each of the coating liquid distributing tubes (25a-25d) have the same length. A vibrator (24) is mounted to the distributor (21), and the core liquid (5) is supplied to the nozzles (2a-2d) while being vibrated. Each of the distributors (21, 22) is provided with an air vent device (35), and air vent is performed appropriately.