Sample Holder Structure Patents (Class 324/321)
  • Patent number: 11474172
    Abstract: A transfer device is provided for shuttling an NMR sample container between at least two coaxially arranged NMR magnet systems of an NMR spectrometer comprising a guide tube positioned in a central bore of the magnet systems, a shuttle assembly arranged inside the guide tube for securely holding and shuttling the sample container and a drive system comprising a pulling drive and a winch cord attached to the drive system on one side and to the shuttle assembly on the other side, such that the shuttle assembly can travel inside the guide tube. The transfer device has a pneumatic pressurizing arrangement with an entry for pressurized gas arranged on a gas-tight body above the shuttle assembly that is adapted to maintain the winch cord under tension. The shuttle assembly comprises a piston design being moveable along the common axis of the coaxial magnet systems under the influence of the pressure.
    Type: Grant
    Filed: April 7, 2022
    Date of Patent: October 18, 2022
    Inventors: Philipp Aders, Andreas Tilch, Thorsten Marquardsen, Jean-Max Tyburn
  • Patent number: 11397226
    Abstract: A scanning ferromagnetic resonance (FMR) measurement system is disclosed with a radio frequency (RF) probe and one or two magnetic poles mounted on a holder plate and enable a perpendicular-to-plane or in-plane magnetic field, respectively, at test locations. While the RF probe tip contacts a magnetic film on a whole wafer under test (WUT), a plurality of microwave frequencies (fR) is sequentially transmitted through the probe tip. Simultaneously, a magnetic field (HR) is applied to the contacted region thereby causing a FMR condition in the magnetic film for each pair of (HR, fR) values. RF output signals are transmitted through or reflected from the magnetic film to a RF diode and converted to voltage signals which a controller uses to determine effective anisotropy field, linewidth, damping coefficient, and/or inhomogeneous broadening for a sub-mm area. The WUT is moved to preprogrammed locations to enable multiple FMR measurements at each test location.
    Type: Grant
    Filed: August 31, 2020
    Date of Patent: July 26, 2022
    Inventors: Guenole Jan, Son Le, Luc Thomas, Santiago Serrano Guisan
  • Patent number: 11360167
    Abstract: Among the various aspects of the present disclosure is the provision of systems and spherical rotors suitable for use in magic angle spinning (MAS) nuclear magnetic resonance (NMR) spectroscopy and methods of use thereof.
    Type: Grant
    Filed: November 29, 2018
    Date of Patent: June 14, 2022
    Assignee: Washington University
    Inventor: Alexander Barnes
  • Patent number: 11340199
    Abstract: Provided are two-dimensional chromatography systems and methods for separating and/or analyzing complex mixtures of organic compounds. In particularly, a two-dimensional reversed-phase liquid chromatography (RPLC)—supercritical fluid chromatography (SFC) system is described including a trapping column at the interface which collects the analytes eluted from the first dimension chromatography while letting the RPLC mobile phase pass through. The peaks of interest from the RPLC dimension column are effectively focused as sharp concentration pulses on the trapping column, which is subsequently injected onto the second dimension SFC column. The system can be used for simultaneous achiral and chiral analysis of pharmaceutical compounds. The first dimension RPLC separation provides the achiral purity result, and the second dimension SFC separation provides the chiral purity result (enantiomeric excess).
    Type: Grant
    Filed: August 27, 2020
    Date of Patent: May 24, 2022
    Assignee: Genentech, Inc.
    Inventors: Cadapakam Venkatramani, Mohammad Al-Sayah
  • Patent number: 11215686
    Abstract: Electrochemical devices with metal casings have been considered incompatible with nuclear magnetic resonance (NMR) spectroscopy because the oscillating magnetic fields (“rf fields”) responsible for excitation and detection of NMR active nuclei do not penetrate metals. According to the present invention, rf fields can still efficiently penetrate into nonmetallic layers of electrochemical cells (such as a coin cell battery configuration) provided the magnetic field is oriented tangentially to the electrochemical cell electrodes in a “skimming” orientation. As an example, noninvasive high field in situ 7Li and 19F NMR of an unmodified commercial off-the-shelf rechargeable coin cell was demonstrated using a traditional external NMR coil setup. The in operando NMR measurements revealed that irreversible physical changes accumulate at the anode during electrochemical cycling.
    Type: Grant
    Filed: February 2, 2021
    Date of Patent: January 4, 2022
    Assignees: National Technology & Engineering Solutions of Sandia, LLC, ABQMR, Inc.
    Inventors: Eric Glenn Sorte, Mark S. Conradi, Brennan J. Walder, Todd M. Alam
  • Patent number: 11209479
    Abstract: Various aspects of the present invention disclose a test device that includes a retaining element retaining one or more nuclear radiation sources for performing a nuclear radiation stress test of data storage structures of integrated circuits on a wafer in a wafer prober. The retaining element includes one or more apertures for applying nuclear radiation from the one or more nuclear radiation sources to the data storage structures. The retaining element is configured for controlling the nuclear radiation applied via the one or more apertures. The controlling includes a varying of relative positions of the one or more nuclear radiation sources and the one or more apertures. Additional aspects of the present invention disclose a testing method, computer program product, and computer system for performing the nuclear radiation stress test. In an example aspect, embodiments of the present invention disclose a test device for a wafer prober.
    Type: Grant
    Filed: October 29, 2019
    Date of Patent: December 28, 2021
    Assignee: International Business Machines Corporation
    Inventors: Martin Eckert, Matthias Pflanz, Otto Andreas Torreiter, Juergen Pille
  • Patent number: 11187767
    Abstract: An MAS probehead (1) positioned in a magnet bore (2) includes a sample chamber (3) with a stator (4) for receiving a rotor and an RF coil that radiates RF pulses into and/or receives RF signals from an NMR sample (5). A temperature-control apparatus guides gas at a first variable temperature T1 into the sample chamber and through the stator during an NMR measurement, and guides a pressurized gas stream at a second variable temperature T2 around the sample chamber. The sample chamber is surrounded by an encapsulation device (6), at least in the azimuthal direction around the axis of the magnet bore and counter to the flow direction of the pressurized gas, and is oriented to provide an air gap (7?) between the sample chamber and the magnet bore. This prevents dissipation of the gas temperature to outer parts of the probehead, and yields larger NMR measurement temperature ranges.
    Type: Grant
    Filed: February 14, 2020
    Date of Patent: November 30, 2021
    Inventors: David Osen, Alexander Krahn, Constantin Schalck
  • Patent number: 11175361
    Abstract: A method for performing an NMR measurement on a sample contained in a sample tube by using an NMR spectrometer includes: a) feeding a first measuring sample tube in a guiding direction to a pre-measuring area being located, in the guiding direction, before a measuring area of the NMR spectrometer, the pre-measuring area being arranged and designed for measuring a sample parameter of a sample contained in the first measuring sample tube to determine or to estimate an NMR parameter; b) feeding the first measuring sample tube in the guiding direction towards the measuring area; c) setting the NMR parameter previously determined or estimated; and d) carrying out an NMR measurement of the sample contained in the first measuring sample tube on the basis of the set NMR parameter.
    Type: Grant
    Filed: March 6, 2017
    Date of Patent: November 16, 2021
    Assignee: numares AG
    Inventors: Fritz Huber, Volker Pfahlert, Martin Reinhard Arnold
  • Patent number: 11156680
    Abstract: The present disclosure discloses a novel assembled nuclear magnetic resonance (NMR) sample tube and an assembly method thereof. The structure includes a common NMR sample tube, a first open-top screw cap and a second open-top screw cap. The first screw cap is sleeved on the common NMR sample tube, and an open end of the first screw cap is tightly connected to an outer wall of the common NMR sample tube. The second screw cap is in threaded connection with the screw thread on the top of the short tube. A short tube is sleeved on the common NMR sample tube, and the screw thread at the bottom of the short tube is in threaded connection with the first screw cap. A silicone rubber septum is located between the open end of the second screw cap and the screw thread on the top of the short tube.
    Type: Grant
    Filed: March 26, 2020
    Date of Patent: October 26, 2021
    Inventors: Changsheng Cao, Yanhui Shi
  • Patent number: 11073583
    Abstract: An NMR spectrometer (1) with a magnet system (2), which has a bore (3) through the magnet center (4) for inserting a measuring sample (5) in a transport container (7), and with a transport device for pneumatic transport of the sample through a transport channel (8) into and out of the magnet system. The transport device includes a mechanical interface (9) with a mounted exchange system (10) which has parking receptacles (11) temporarily storing the transport containers. In a transport position, the parking receptacle is inserted into the transport channel, to be loaded with a transport container, removed from the transport channel for temporarily storing the transport container, and reinserted into the transport channel for further transport of the transport container. In the transport position, the parking receptacle forms a part of the transport channel, which permits a faster automated change of the measuring samples in short measurement cycle times.
    Type: Grant
    Filed: March 24, 2020
    Date of Patent: July 27, 2021
    Inventors: Roger Meister, Reto Schmid, Sven Sieber
  • Patent number: 11061088
    Abstract: A container has a sample installation unit and an NMR circuit therein, and is connected to a bearing gas supply path and a drive gas supply path for supplying gas to the inside of that container. This container is also connected to an exhaust path that exhausts the gas from the inside of the container. The exhaust path has a pressure control valve as an adjustment mechanism for adjusting the pressure in the container.
    Type: Grant
    Filed: August 22, 2019
    Date of Patent: July 13, 2021
    Assignees: Osaka University, JEOL Ltd.
    Inventors: Toshimichi Fujiwara, Yoh Matsuki, Yuki Endo, Shinji Nakamura, Hiroki Takahashi
  • Patent number: 11015264
    Abstract: A diamond substrate according to an embodiment includes a diamond layer including at least one first element selected from the group consisting of nitrogen (N), phosphorus (P), arsenic (As), antimony (Sb), and bismuth (Bi), the number of threefold coordinated atoms of the at least one first element in the diamond layer being larger than the number of fourfold coordinated atoms of the at least one first element in the diamond layer, a surface of the diamond layer having an off angle of 10 degrees or less with respect to a (111) face.
    Type: Grant
    Filed: February 8, 2019
    Date of Patent: May 25, 2021
    Assignee: Kabushiki Kaisha Toshiba
    Inventor: Tatsuo Shimizu
  • Patent number: 11009573
    Abstract: A liquid-state nuclear-magnetic-resonance measurement cell includes a reservoir for a liquid medium; a fluidic circuit connected to the reservoir and comprising a measurement chamber; a gas injector opening into the fluidic circuit, at a distance from the measurement chamber; and a coil encircling the measurement chamber; wherein it also comprises at least one capacitive element forming, with the coil, an electromagnetic resonator; and in that it has a shape allowing its introduction into a nuclear-magnetic-resonance probe in replacement of an assembly formed by a nuclear-magnetic-resonance tube and a spinner bearing the tube, the coil encircling the measurement chamber being then positioned so as to couple by induction to at least one radiofrequency coil of the probe. Nuclear-magnetic-resonance measurement system comprising such a measurement cell. Magnetic-resonance measurement method using such a cell is also provided.
    Type: Grant
    Filed: March 8, 2018
    Date of Patent: May 18, 2021
    Inventors: Guillaume Carret, Thomas Berthelot, Patrick Berthault
  • Patent number: 10890448
    Abstract: The invention pertains to the field of gyroscopes, in particular—to quantum gyroscopes. The invention provides a gyroscope employing an ensemble of NV-centers in diamond, which includes a diamond plate, a source of green light, an optical system for directing the green light to the diamond plate, a photodetector for registering fluorescence of the color centers in the diamond plate, optical elements that direct the fluorescence from the diamond plate to the photodetector, a source of microwave radiation, a source of radiofrequency radiation, and a source of constant magnetic field, the gyroscope being different from the prior art in that it comprises an energy-efficient antenna that creates a strong longitudinal homogeneous field in the entire volume of the diamond plate with the possibility of frequency adjustment, as well as a system for locking the frequency of the microwave field to that of the transition in the color centers.
    Type: Grant
    Filed: April 24, 2017
    Date of Patent: January 12, 2021
    Assignee: Q-Sensorix LLC
    Inventors: Vadim Vladislavovich Vorobyov, Vladimir Vladimirovich Soshenko, Stepan Viktorovich Bolshedvorskii, Alexey Vladimirovich Akimov, Andrey Nikolaevich Smolyaninov
  • Patent number: 10874368
    Abstract: An animal carrying bed includes a tubular unit, an electrical connector and an end cover unit. The electrical connector is arranged on one end of the tubular unit, and the end cover unit is arranged at another end thereof. The end cover unit is formed of an intake channel and a discharge channel therein and separated from each other. The end cover unit is formed of an intake opening inside the tubular unit and connected to the intake channel. The end cover unit is formed of a plurality of discharge openings inside the tubular unit and connected to the discharge channel. The intake channel and the discharge channel are connected to the electrical connector via guide tubes respectively, and the guide tubes are installed inside the tubular unit.
    Type: Grant
    Filed: January 13, 2018
    Date of Patent: December 29, 2020
    Inventors: Yi-Da Tsai, Chih-Yuan Hsu
  • Patent number: 10802102
    Abstract: A pulsed electron paramagnetic resonance spectrometer comprises: a microwave excitation generating unit for generating at least one microwave pulse; a microwave conducting unit comprising a resonant cavity and a microwave transmission line for transmitting microwaves, wherein the microwave transmission line is connected between the microwave excitation generating unit and the resonant cavity, and the resonant cavity is for placing a sample; a cryostat and magnet unit comprising a cryostat that performs ultra-low temperature cooling for the microwave resonant cavity, the microwave transmission line being disposed to pass through the cryostat and connected to the resonant cavity; the cryostat and magnet unit further comprises a magnet that provides a resonance test magnetic field around the sample, the resonant cavity being disposed in a room temperature gap of the magnet. The device of the present disclosure characteristics in ultra-low sample temperature (0.
    Type: Grant
    Filed: March 8, 2018
    Date of Patent: October 13, 2020
    Assignee: University of Science and Technology of China
    Inventors: Zongquan Zhou, Peiyun Li, Chao Liu, Xiao Liu, Chuanfeng Li, Guangcan Guo
  • Patent number: 10788467
    Abstract: Provided are two-dimensional chromatography systems and methods for separating and/or analyzing complex mixtures of organic compounds. In particularly, a two-dimensional reversed-phase liquid chromatography (RPLC)—supercritical fluid chromatography (SFC) system is described including a trapping column at the interface which collects the analytes eluted from the first dimension chromatography while letting the RPLC mobile phase pass through. The peaks of interest from the RPLC dimension column are effectively focused as sharp concentration pulses on the trapping column, which is subsequently injected onto the second dimension SFC column. The system can be used for simultaneous achiral and chiral analysis of pharmaceutical compounds. The first dimension RPLC separation provides the achiral purity result, and the second dimension SFC separation provides the chiral purity result (enantiomeric excess).
    Type: Grant
    Filed: September 7, 2018
    Date of Patent: September 29, 2020
    Assignee: Genentech, Inc.
    Inventors: Cadapakam Venkatramani, Mohammad Al-Sayah
  • Patent number: 10782369
    Abstract: Transport apparatus pneumatically conveying NMR test samples (2) from or to an NMR spectrometer (1) through a tubular transport channel (3) includes a device (4) generating positive pressure in the end of the transport channel that is remote from the spectrometer. The transport channel has a tube system which has a gas-tight outer tube (5) having an outer diameter Da and an inner diameter da and an inner tube (6), arranged coaxially with respect to the outer tube, having an outer diameter Di<da and an inner diameter di. The inner diameter di of the inner tube is greater than or equal to the outer diameter DP of the test samples, and the inner tube includes mutually spaced cross-holes (7) designed as through-holes. This provides accurate current position determinations for the sample in the transport channel, and reduced risk of damaging the sample during transport.
    Type: Grant
    Filed: April 11, 2019
    Date of Patent: September 22, 2020
    Inventors: Reto Schmid, Sven Sieber
  • Patent number: 10768248
    Abstract: An NMR probe head (1) having an RF coil arrangement (2a) in a coil region (2) and an RF shielding tube (3) for supply lines leading from a connection region (4) to the coil region. An elongated backbone (5) is arranged inside the shielding tube and has an inherently rigid, mechanically stiff structure having continuous bores and/or connecting channels (5a) which run parallel to the tube axis and accommodate the supply lines. The backbone has a continuously electrically conductive outer surface which leads from the connection region to the coil region and is electrically conductively connected to the conductive inner surface of the shielding tube via connecting elements (6). A continuous electrically conductive contour is formed thereby between the backbone and the shielding tube. This shields against externally incident RF fields and spatially separates the stable mechanical supporting construction and the supply lines from the electronic and RF components.
    Type: Grant
    Filed: February 26, 2019
    Date of Patent: September 8, 2020
    Inventors: Priyanga Bandara, Ralf Haueisen, Juergen Ganz, David Osen, Martin Armbruster, Alexander Krahn
  • Patent number: 10697910
    Abstract: A porous material with liquid in the pores is examined by submerging the material in a bathing liquid, possibly a perfluorocarbon, which is immiscible with the liquid in the pores, is non-wetting towards the material, is immiscible with and differs in density from any liquid on the outside of the material, and does not contain a resonant element found in the bathing liquid. This bathing liquid displaces fluid from the surface of the porous material but not the liquid in the pores. Nuclear magnetic resonance signals from liquid in the pores give a measurement of pore volume. Volume of bathing liquid displaced by the porous material gives the bulk volume and porosity can be derived from these measurements. Sample preparation is minimal and a benchtop spectrometer can be used, making the method practical for examination of drill cuttings from a borehole while drilling.
    Type: Grant
    Filed: September 14, 2016
    Date of Patent: June 30, 2020
    Inventors: Jonathan Mitchell, Edmund John Fordham
  • Patent number: 10649047
    Abstract: An MAS NMR probe head arrangement has a stator (2) aligned along an axis of rotation (RA) to support a rotor (1), a stator mount (32), and a RF coil arrangement (21) to emit/receive RF pulses into/from the measurement substance (40) in the rotor. The stator mount has a stator bearing (41) into which the stator can be axially inserted and extracted. The stator, when inserted, passes through the RF coil arrangement (21), and can be fed through the RF coil arrangement (21). A mechanism fixes the stator axially in the stator bearing (41) when inserted. This arrangement enhances both ease of assembly and maintenance of the arrangement.
    Type: Grant
    Filed: November 19, 2018
    Date of Patent: May 12, 2020
    Inventors: Nicolas Freytag, Fabian Kuehler, David Osen
  • Patent number: 10620227
    Abstract: An automatic fluid sampler works in conjunction with a conventional oil well test system. The sampler utilizes a rotating platter which aligns the mouth of a sampling container with a conduit for delivery of a composite sample which is provided in incremental volumes over the duration of a well test event. Upon completion of the well test, a fresh container is rotated to be in position to receive a composite sample for a new well test event.
    Type: Grant
    Filed: September 26, 2019
    Date of Patent: April 14, 2020
    Inventor: Paul Wade
  • Patent number: 10550889
    Abstract: Snap-in bushings are disclosed that enable sealing of sample chambers in MAS-NMR rotors for high pressure and/or high temperature operation that enhance pressure limits up to about 400 bar and temperature limits up to at least about 250° C.
    Type: Grant
    Filed: August 1, 2016
    Date of Patent: February 4, 2020
    Assignee: Battelle Memorial Institute
    Inventors: Eric D. Walter, Jesse A. Sears, Jr., Hardeep S. Mehta, David W. Hoyt
  • Patent number: 10459044
    Abstract: A method for operating an NMR probehead (10) with an MAS stator (11) receiving a circular-cylindrical hollow MAS rotor (13) with an outer jacket. The MAS rotor is mounted on pressurized gas in a measuring position within the MAS stator via a gas supply device with a bearing nozzle (12?) and rotates about the cylinder axis of the MAS rotor at a rotation frequency f?30 kHz. During a measurement, a temperature control gas is blown by a temperature control nozzle (12) onto the outer jacket of the rotor at an angle ?<90° with respect to the longitudinal axis of the cylinder-symmetrical rotor. The flow speed of the temperature control gas corresponds in the nozzle cross section to at least half the circumferential speed of the outer jacket of the rotating rotor and to at most the speed of sound in the temperature control gas.
    Type: Grant
    Filed: September 28, 2017
    Date of Patent: October 29, 2019
    Inventors: David Osen, Armin Purea, Benno Knott, Fabian Kuehler, Florian Helbing, Alia Hassan, Jevgeni Guidoulianov, Nicolas Freytag
  • Patent number: 10230273
    Abstract: An electricity transmission sending device includes: a transmission circuit and a coil, where the transmission circuit includes a signal sending unit and a controlling unit, and the coil includes at least two mutually perpendicular subcoils. The signal sending unit is configured to receive a required power signal and an actually received power signal that are sent by the electricity transmission receiving device; and the controlling unit is configured to adjust a magnetic field direction in which wireless electricity transmission to the electricity transmission receiving device is performed and control the coil to transmit electric energy to the electricity transmission receiving device in an optimal magnetic field direction, where the optimal magnetic field direction refers to a corresponding magnetic field direction when a power value of electric energy actually received by the electricity transmission receiving device is maximum in a case of specific output power of the coil.
    Type: Grant
    Filed: December 24, 2014
    Date of Patent: March 12, 2019
    Assignee: Huawei Technologies Co., Ltd.
    Inventors: Fuchao Wang, Fan Tian, Yuchao Zhang
  • Patent number: 10218160
    Abstract: Systems and methods are disclosed herein for an electrical harness. The electrical harness may include a high temperature segment, a low temperature segment, and a transition segment between the high temperature segment and the low temperature segment. The electrical harness may include a conductor disposed within the electrical harness.
    Type: Grant
    Filed: December 19, 2017
    Date of Patent: February 26, 2019
    Inventor: Ryan K Snyder
  • Patent number: 10191027
    Abstract: This invention concerns methods of determining properties of oil, especially crude oil with a spectrometer. This invention also concerns a crude oil analytical and single or multi-stream sampling device which is particularly suitable for the online measurement of crude oil properties with a spectrometer (8). This invention further concerns a crude oil sampling procedure which is particularly suitable for the online measurement of crude oil properties with a spectrometer.
    Type: Grant
    Filed: August 3, 2015
    Date of Patent: January 29, 2019
    Inventors: Didier Lambert, Claude Saint Martin, Miguel Sanchez, Bernard Ribero, Pierre Barere
  • Patent number: 10126380
    Abstract: A selectively removable closure for closing the open end of an NMR sample tube having an open end and a closed end of the invention includes a cylindrical proximal first and a distal second portion, both portions substantially congruent to a central axis, the second portion has a hollow bore extending therethrough, the hollow bore has: a first and a second distal section, a central section and a proximal section. The first distal section has an inside diameter sized to accept the outside diameter of a preselected size NMR sample tube substantially without an interference, the second distal section has an interference that ends into the central section with a ramp with an angle to the central axis greater than 70 degrees, the central section corresponds in a locked position on the NMR sample tube with a locking ring at least partially surrounding the NMR locking tube to form a secondary locking seal.
    Type: Grant
    Filed: June 15, 2015
    Date of Patent: November 13, 2018
    Inventor: Gregory B. Norell
  • Patent number: 10120044
    Abstract: An NMR DNP-MAS probe head (10) has an MAS stator (2) for receiving an MAS rotor (3) having a sample substance in a sample volume (4), and a hollow microwave waveguide (5)? for feeding microwave radiation through an opening (5a) of the microwave waveguide into the sample volume, an axially expanded rod-shaped microwave coupler (6) located in the opening made of dielectric material, characterized in that the microwave waveguide has a conically tapered hollow transition piece for coupling in an HE 11 mode, into which the microwave coupler projects at an all-round radial distance to the opening of the microwave waveguide. It is thus possible, in a surprisingly simple manner and by means of readily available technical means, to irradiate a considerably higher microwave energy in the HE 11 mode into the NMR measuring sample than by means of the known arrangements.
    Type: Grant
    Filed: July 23, 2014
    Date of Patent: November 6, 2018
    Assignee: Bruker BioSpin GmbH
    Inventors: Armin Purea, Frank Engelke, Alexander Krahn
  • Patent number: 10101416
    Abstract: The method comprises an initial cooling step (E0) during which the temperature (T_ECH) of the heat exchanger (30) is lowered and, at the same time, the flow rate of the said first flow (FLS) is set to an initial flow rate. Following the initial cooling step (E0), an operation of circulating the first flow (FLS) is initiated (E1) and during this the said first flow (FLS) passes through a heat exchange (30) at a first flow rate which is higher than the initial flow rate. The initial flow rate of the first flow may be set to zero or to a value set so that the pressure inside the said circuit is greater than or equal to the pressure outside the said circuit.
    Type: Grant
    Filed: February 18, 2016
    Date of Patent: October 16, 2018
    Inventors: Eric Bouleau, Pierre Saint-Bonnet
  • Patent number: 10088538
    Abstract: An inner container including a tube body is provided in an outer container. With this structure, the inside of the outer container is separated into a primary airtight chamber and a sub airtight chamber (upper airtight chamber and lower airtight chamber). A detection circuit is placed in the primary airtight chamber. The detection circuit is a tuning and matching circuit having a transmission and reception coil serving as an NMR detection element and a variable capacitor. An additional member including an additional element such as a capacitor is inserted into the upper airtight chamber, and the additional member is set on a top terminal mounting member and a bottom terminal mounting member. With this structure, the additional element is electrically connected to the detection circuit and a characteristic of the detection circuit is changed.
    Type: Grant
    Filed: February 3, 2016
    Date of Patent: October 2, 2018
    Assignee: JEOL Ltd.
    Inventors: Takashi Mizuno, Kiyonori Takegoshi, Koji Fujioka
  • Patent number: 10067214
    Abstract: A new imaging phantom called a “fusion phantom” enhances the efficiency of performance testing and quality control. The phantom relocates the test elements of a standard MRI phantom, and provides a configuration of inner containers that enables simultaneous performance testing on magnetic resonance imaging and magnetic resonance spectroscopy within a predetermined error range. The fusion phantom is useful for multi-purpose performance testing of magnetic resonance imaging equipment, including correlation analysis, performance testing, system management and the like in the diagnosis field. The fusion phantom enhances efficiency of time and reliability in testing performance of the magnetic resonance imaging equipment, adjusts incorrect position accuracy and improves quality of images.
    Type: Grant
    Filed: February 24, 2015
    Date of Patent: September 4, 2018
    Assignee: The Catholic University of Korea Industry-Academic Cooperation Foundation
    Inventors: Bo Young Choe, Kyu-Ho Song, Sang-Young Kim, Do-Wan Lee
  • Patent number: 10031196
    Abstract: A nuclear magnetic resonance (NMR) probe cassette, with a removable conduit body made of a non-magnetic material having a longitudinal axis with an opening at one end, centered on the axis. The conduit body is reversibly connected to a heat exchanger to substantially maintain the conduit body at a predetermined temperature. The NMR probe cassette also includes a second conduit made of a non-magnetic material. The second conduit extends through the central opening in the first conduit body and is configured to receive and contain a sample. Still further, the NMR probe cassette includes a processor and computer readable media with instructions for controlling the heat exchanger.
    Type: Grant
    Filed: October 2, 2014
    Date of Patent: July 24, 2018
    Assignee: Aspect AI Ltd.
    Inventors: Itzchak Rabinovitz, Tal Cohen
  • Patent number: 9983277
    Abstract: A sample holder that can withstand high pressures and temperatures is disclosed. The sample holder can be used to subject a geological sample to the same temperature and pressure that the sample would experience in its native underground environment. The sample holder provides a mechanism for hydrostatically confining the rock core sample to simulate the below ground pressure, while simultaneously allowing fluid to be directed through the core, as needed. The material used for the housing of the sample holder, specifically ceramic zirconia, and the mechanism by which the end fixtures are mounted in the housing, e.g., a square thread or modified square thread, allow for operation at higher pressures and temperatures than is offered by currently available systems. The sample holder can be used to analyze rock core samples via NMR spectroscopy or MRI.
    Type: Grant
    Filed: March 5, 2015
    Date of Patent: May 29, 2018
    Inventor: Ronald W. Peterson
  • Patent number: 9903923
    Abstract: A transport device for transporting an NMR sample to the probe head (16) of an NMR spectrometer by means of a transport system (12) is characterized in that the transport device comprises a shuttle (15) adapted for use with a transport system. The transport system is structured to transport an HR-NMR sample spinner or an NMR MAS rotor (5). The shuttle includes a locking device for the NMR MAS rotor, the locking device being formed such that the NMR MAS rotor is released by unlocking the locking device and can be transferred to and received by the NMR MAS probe head. It is therefore possible to rapidly change from NMR spectroscopy of liquids to NMR spectroscopy of solids, and vice versa, simply by exchanging the probe head, without converting the transport system.
    Type: Grant
    Filed: January 19, 2015
    Date of Patent: February 27, 2018
    Assignee: Bruker BioSpin AG
    Inventors: Oskar Schett, Daniel Guy Baumann, Franco Sestito, Markus Mayer
  • Patent number: 9835698
    Abstract: A high-pressure magic angle spinning (MAS) rotor is detailed that includes a high-pressure sample cell that maintains high pressures exceeding 150 bar. The sample cell design minimizes pressure losses due to penetration over an extended period of time.
    Type: Grant
    Filed: January 27, 2014
    Date of Patent: December 5, 2017
    Assignee: Battelle Memorial Institute
    Inventors: David W. Hoyt, Jesse A. Sears, Romulus V. F. Turcu, Kevin M. Rosso, Jian Zhi Hu
  • Patent number: 9817094
    Abstract: A nuclear magnetic resonance (NMR) apparatus includes at least one magnet configured to induce a static magnetic field in a sample of material to be analyzed. At least one radio frequency antenna is configured to induce a radio frequency magnetic field in the sample of material to be analyzed. The sample chamber is disposed in a substantially longitudinally continuous sample holder separated into discrete sample chambers. Each sample chamber has an internal opening dimension such that substantially all of each sample is affected by surface contact phenomena with an internal wall of each sample chamber.
    Type: Grant
    Filed: November 5, 2014
    Date of Patent: November 14, 2017
    Inventor: Gersh Z. Taicher
  • Patent number: 9791584
    Abstract: The presence of hydrocarbons in a subsurface formation fluid may be inferred from a determined salt concentration. A sodium nuclear magnetic resonance (NMR) measurement of a subsurface formation is obtained and a salt concentration of the fluid in the subsurface formation is determined from the sodium NMR measurement. Various operations may be performed using the determined salt concentration such as tracking injected water, monitoring flood fronts, improving reserves estimation, and designing enhanced oil recovery. A sodium index may be determined and used in conjunction with one or more other logs to determine a saturation of the subsurface formation. The one or more other logs may include a resistivity log, a dielectric log, a capture cross section (sigma) log, and a proton NMR log. Differentiation between bound water and free water can also be achieved using the sodium nuclear magnetic resonance measurement.
    Type: Grant
    Filed: May 13, 2014
    Date of Patent: October 17, 2017
    Inventor: Chanh Cao Minh
  • Patent number: 9778331
    Abstract: An NMR MAS probe head (1) has an MAS stator (7) with a base bearing (8) and a front bearing (75) for receiving a substance to be measured at a measurement position within an MAS rotor. The front bearing has an opening for inserting the MAS rotor into the space between the base bearing and the front bearing. The opening can be closed by a closing device that, in a loading state, opens and, in a measuring state, closes the opening by means of a movement that is transverse with respect to an axis (a) through the centers of the base bearing and the opening of the front bearing of the MAS stator. This enables automated loading and unloading of the MAS rotor in the space between the base bearing and the front bearing inside the MAS stator in a simple way.
    Type: Grant
    Filed: January 16, 2014
    Date of Patent: October 3, 2017
    Inventors: Andreas Hunkeler, Benno Knott, David Osen
  • Patent number: 9778332
    Abstract: A spinning controller has an arithmetic unit (18) and a controller (20). The arithmetic unit (18) establishes gate periods Tg for a pulse sequence signal (110) produced concomitantly with spinning of a sample tube (40) and obtains a count value (Ns) by counting the number of pulses falling within each gate period Tg. The arithmetic unit (18) has functions of finding differences in time from each gate period Tg to the pulse sequence signal (110) occurring around the starting point and ending point of each gate period Tg by making use of a high-speed clock signal (120) and of correcting the duration of the gate period Tg, based on the differences in time.
    Type: Grant
    Filed: April 16, 2014
    Date of Patent: October 3, 2017
    Assignee: JEOL Ltd.
    Inventors: Tomio Ozaku, Yusuke Nishiyama
  • Patent number: 9638776
    Abstract: Embodiments of the invention are utilized to improve shimming capability while reducing radial space and the volume required to contain active shim coils by nesting the coils of different degrees and orders inside each other and limiting the azimuthal span of the individual saddle coils. This allows two or more radial shim sets to be combined together in the same layer resulting in a significant radial savings that increases the useable portion of an MRI system.
    Type: Grant
    Filed: August 22, 2014
    Date of Patent: May 2, 2017
    Assignee: General Electric Company
    Inventors: Michael Parizh, Derek Allan Seeber, Seung-Kyun Lee, Jean-Baptiste Mathieu
  • Patent number: 9547052
    Abstract: There is disclosed an NMR (nuclear magnetic resonance) spinner having a turbine structure and a rotor whose spinning rate can be increased. A vortical channel (44) is formed around the rotor (12). The vortical channel (44) consists of a chamber (66) and a nozzle array (68) mounted inside the chamber (66). The chamber (66) has a cross-sectional area that decreases in an upstream to downstream direction. The cross-sectional area of each nozzle also decreases in an upstream to downstream direction. Gas is introduced into the chamber (66), creating a rotating flow (76, 78, 80) in the chamber (66). Plural inwardly swirling streams are created from the inside of the rotating flow. The inwardly swirling streams are ejected from the exits of the nozzles. This results in jet streams, which are blown against the impeller of the rotor, spinning the rotor at high speed.
    Type: Grant
    Filed: October 8, 2013
    Date of Patent: January 17, 2017
    Assignee: JEOL Ltd.
    Inventor: Yuki Endo
  • Patent number: 9448291
    Abstract: The present invention is related to systems and methods for chemical and biological analysis and, in particular, to systems, apparatus, and methods of sample conditioning and analysis.
    Type: Grant
    Filed: October 4, 2012
    Date of Patent: September 20, 2016
    Assignee: Pressure BioSciences, Inc.
    Inventors: Edmund Y. Ting, Alexander Lazarev
  • Patent number: 9448192
    Abstract: A monitoring cell, used to perform a measurement in an NMR spectrometer of a reaction fluid produced by a reaction vessel, has a body having inlet and outlet transport coaxial capillaries for transporting the reaction fluid between the body and the reaction vessel. Cooling lines are also positioned coaxially with the transport capillaries to transport cooling liquid between the body and the reaction vessel. The cell further has a hollow sample probe for insertion into the NMR spectrometer and a coupler section that removably connects the sample probe to the body so that the inlet transport capillary extends through the body into the interior of the sample probe and the outlet transport capillary is sealed to the sample probe to allow reaction fluid that enters the sample probe via the inlet transport capillary to exit the sample probe via the outlet transport capillary.
    Type: Grant
    Filed: March 31, 2014
    Date of Patent: September 20, 2016
    Assignee: Bruker Biospin Corporation
    Inventors: Brian Marquez, Michael Fey, Kimberly L. Colson, Robert Krull, Eckhard Bez, Don Piroli, Werner E. Maas
  • Patent number: 9389287
    Abstract: In a nuclear magnetic resonance (NMR) spectrometer, a sample spins about an axis tilted at a magic angle, a corrective magnetic field generating portion produces a corrective magnetic field, and a control portion controls the operation of the corrective magnetic field generating portion. An arithmetic unit included in the control portion uses at least one of BZ(1), B1(1)e, and B1(1)o or the linear sum of at least two of them as the first-order magnetic field component of the corrective magnetic field, uses at least one of B2(2)e, B2(2)o, B2(1)e, and B2(1)o or the linear sum of at least two of them as the second-order magnetic field component of the corrective magnetic field, and uses at least one of BZ(3), B3(1)e, B3(1)o, B3(2)e, B3(2)o, B3(3)e, and B3(3)o or the linear sum of at least two of them as the third-order magnetic field component of the corrective magnetic field.
    Type: Grant
    Filed: February 6, 2012
    Date of Patent: July 12, 2016
    Assignee: JEOL Ltd.
    Inventor: Yusuke Nishiyama
  • Patent number: 9372246
    Abstract: The flow-through NMR analyzer comprises: a solution feeding pipe for flowing a sample; a superconducting magnet that encloses a housing space, which is surrounded by a side wall of the solution feeding pipe, around an axis of the solution feeding pipe such that a static magnetic field is generated along the axis of the solution feeding pipe; a vacuum container which houses the superconducting magnet in a cooled state and which encloses the housing space around the axis of the solution feeding pipe; and an RF coil which applies high-frequency electromagnetic waves to the sample inside the housing space and which detects an NMR signal from the sample. The RF coil is integrally formed with the side wall of the solution feeding pipe in a region of the solution feeding pipe that is enclosed by the superconducting magnet and the magnetic field correcting coil.
    Type: Grant
    Filed: March 25, 2011
    Date of Patent: June 21, 2016
    Assignee: Kobe Steel, Ltd.
    Inventor: Takashi Miki
  • Patent number: 9366736
    Abstract: A magic-angle-spinning (MAS) nuclear magnetic resonance (NMR) probe is described that includes double containment enclosures configured to seal and contain hazardous samples for analysis. The probe is of a modular design that ensures containment of hazardous samples during sample analysis while preserving spin speeds for superior NMR performance and convenience of operation.
    Type: Grant
    Filed: December 13, 2013
    Date of Patent: June 14, 2016
    Inventors: Herman M. Cho, Nancy M. Washton, Karl T. Mueller, Jesse A. Sears, Jr., Mark R. Townsend, R. James Ewing
  • Patent number: 9279869
    Abstract: An NMR probe has a sample tube insertion port for introducing and withdrawing the sample tube into and from the probe, a sample tube support providing support of the sample tube during NMR measurements, a tubular sample tube passage connecting together the sample tube insertion port and the sample tube support and capable of transporting the sample tube between them, and a gas stream generator for producing a gas stream in the sample tube passage to move the sample tube between the sample tube insertion port and the tube support. The gas stream generator is mounted at an intermediate (non-end) position in the sample tube passage.
    Type: Grant
    Filed: February 13, 2013
    Date of Patent: March 8, 2016
    Assignee: JEOL Resonance Inc.
    Inventors: Hideyuki Shinagawa, Tadashi Shimizu, Shinobu Ohki, Takahiro Nemoto, Eijiro Baba, Katsuya Hioka
  • Patent number: 9190707
    Abstract: The invention relates to a method for manufacturing an RF filter comprising several resonator cavities and an RF filter manufactured by the method. The resonator cavities are formed into shape from a copper plate in a first manufacturing phase. In a second manufacturing phase the formed resonator cavities are inserted or integrated into a chassis material of the RF filter.
    Type: Grant
    Filed: November 11, 2011
    Date of Patent: November 17, 2015
    Assignee: Prism Microwave, Inc.
    Inventors: Mika Hedemaki, John Kevin Pryor, William Baldwin Johnson
  • Patent number: 9110132
    Abstract: Imaging signals from one or more surface coils are directed outwardly through a rear end portion of an imaging bore of an imaging machine, such as a magnetic resonance imaging machine (MRI). Initial processing of the imaging signals can be carried out within the imaging bore and transmitted through a pair of releasable connectors to external imaging processing equipment. By routing the surface coil imaging signals through the open rear end of an imaging bore, wires and other signal processing components need not be squeezed through the relatively limited space available around the front portion of an imaging bore. Fluid passages can be provided through the pair of releasable connectors for the passage of heating fluids, cooling fluids, and pressurized gasses including anesthesia gasses.
    Type: Grant
    Filed: August 3, 2012
    Date of Patent: August 18, 2015
    Inventor: Chris Chiodo