Sample Holder Structure Patents (Class 324/321)
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Publication number: 20120313644Abstract: Disclosed is a reference material for NMR, including a nitrogen-containing compound or oxygen-containing compound and a reagent for shifting a chemical shift for the nitrogen-containing compound or oxygen-containing compound. Disclosed is a sample tube for NMR, being obtainable by providing a reference material for NMR to a first tube closed at one end, providing a second tube closed at one end into the first tube, and fusing the other end of the first tube and the other end of the second tube and sealing a gap between the other end of the first tube and the other end of the second tube.Type: ApplicationFiled: December 28, 2010Publication date: December 13, 2012Applicant: SHISEIDO COMPANY, LTD.Inventors: Haruo Shimada, Keiko Ootake
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Publication number: 20120313639Abstract: This invention relates generally to detection devices having one or more small wells each surrounded by, or in close proximity to, an NMR micro coil, each well containing a liquid sample with magnetic nanoparticles that self-assemble or disperse in the presence of a target analyte, thereby altering the measured NMR properties of the liquid sample. The device may be used, for example, as a portable unit for point of care diagnosis and/or field use, or the device may be implanted for continuous or intermittent monitoring of one or more biological species of interest in a patient.Type: ApplicationFiled: June 25, 2012Publication date: December 13, 2012Applicant: T2 Biosystems, Inc.Inventor: W. David LEE
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Patent number: 8310235Abstract: The subject apparatus is a fuel cell toroid cavity detector for in situ analysis of samples through the use of nuclear magnetic resonance. The toroid cavity detector comprises a gas-tight housing forming a toroid cavity where the housing is exposed to an externally applied magnetic field B0 and contains fuel cell component samples to be analyzed. An NMR spectrometer is electrically coupled and applies a radiofrequency excitation signal pulse to the detector to produce a radiofrequency magnetic field B1 in the samples and in the toroid cavity. Embedded coils modulate the static external magnetic field to provide a means for spatial selection of the recorded NMR signals.Type: GrantFiled: November 16, 2007Date of Patent: November 13, 2012Assignee: U.S. Department of EnergyInventors: Rex E. Gerald, II, Jerome W. Rathke
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Publication number: 20120268131Abstract: A measuring apparatus for a magnetic resonance apparatus is proposed. The measuring apparatus has a charging apparatus and a mobile sensor unit for detecting a physiological signal of a patient. The mobile sensor unit includes a sensor element and an energy storage element which supplies electrical energy to the sensor element in an operating mode. The charging apparatus in a charging process increases a charging state of the energy storage element of the mobile sensor unit so that the mobile sensor unit can be coupled to the charging apparatus which has an energy buffering unit.Type: ApplicationFiled: April 18, 2012Publication date: October 25, 2012Inventors: Bernd Assmann, Michael Frank, Sven Heggen, Ernst Mustafa, Jürgen Rössler
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Publication number: 20120262178Abstract: A device for performing chromatographic separations and nuclear magnetic resonance analysis has trapping means for holding a separated sample and to form a held separated sample and placing said held separated sample in said nuclear magnetic resonance assembly. One preferred trapping means forms a held separated sample and a passed separated sample. The passed separated sample is discharged from the device. Preferred trapping means comprise a trapping column or a separated sample loop.Type: ApplicationFiled: October 4, 2011Publication date: October 18, 2012Applicant: WATERS TECHNOLOGIES CORPORATIONInventors: Theodore A. Dourdeville, Charles H. Phoebe, JR.
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Publication number: 20120256099Abstract: A mobile diagnostic imaging system includes a battery system and charging system. The battery system is located in the rotating portion of the imaging system, and includes one or more battery packs, comprising electrochemical cells. Each battery pack includes a control circuit that controls the state of charge of each of the electrochemical cells, and implements a control scheme that causes the electrochemical cells to have a similar charge state. The battery system communicates with a charging system on the non-rotating portion to terminate charge when one or more of the electrochemical cells reach a full state of charge. The imaging system also includes a docking system that electrically connects the charging system to the battery system during charging and temporarily electrically disconnects the rotating and non-rotating portions during imaging, a drive mechanism for rotating the rotating portion relative to the non-rotating portion.Type: ApplicationFiled: April 6, 2012Publication date: October 11, 2012Applicant: MOBIUS IMAGING, LLCInventors: Eugene A. GREGERSON, Michael Connor, Michael Allen, Paul Sebring, Robert Powell, Russell Stanton, Scott Coppen
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Publication number: 20120256632Abstract: A sample container (2) for NMR measurements defines a volume (V) of sample substance. The sample container (2) has a first interface (G1) towards an environment (1) and a second interface (G2) towards the sample substance (3). A susceptibility jump at the second interface G2 is sufficiently large that the maximum value of |B?G2/B0| within the volume (V) is at least 0.5 ppm. The geometry of the sample container (2) is selected in such a fashion that, when a homogeneous magnetic field B0 has been applied, a location-dependent relative field change F is present in the volume (V), which is larger than 20 ppb at least at one point in a center partial volume (V1) and a first residual field (R1) in the center partial volume (V1) is smaller than 1.6 ppb. A second residual field (R2a) in the lower partial volume (V2a) is smaller than 30 ppb.Type: ApplicationFiled: March 11, 2012Publication date: October 11, 2012Inventors: Dirk Wilhelm, Thomas Speck, Oskar Schett
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Publication number: 20120242336Abstract: An NMR measuring system with an NMR probehead has at least one cooling device (5a, b) generating a vibration spectrum of individual selective frequencies. The cooling device is mechanically connected to a vibration absorber (9a, 9b) having an oscillating mass element (27), whose resonance frequency is adjusted to the vibration frequency of the cooling device and/or to one of its harmonics. The cooling device has a cooling head which is thermally connected to an NMR resonator of the probehead via a flexible mechanical element. A vacuum housing of the probehead is designed in two parts which are mechanically connected via at least one damping element (30a-d). The lower part and the upper part of the vacuum housing are additionally mechanically flexibly connected to each other in a vacuum-tight fashion via a corrugated bellows (8a, 8b). The system minimizes sidebands in NMR spectra.Type: ApplicationFiled: March 1, 2012Publication date: September 27, 2012Inventors: Philippe Stauffenegger, Klemens Kessler, Marco Tomaselli, Sven Radke, Bernhard Felber
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Patent number: 8269497Abstract: An NMR probe which includes a probe matrix (24) having a void sample (28) volume therein. A conductive coil (16, 26) can be at least partially embedded in the probe matrix (24). By embedding the conductive coil (16, 26) in the probe matrix (24), the fill-factor can be significantly increased. NMR probes can be formed by a method which includes wrapping a conductive wire (16) around a coil form (18) to produce a coil precursor assembly. The probe matrix (24) can be formed around the conductive wire and coil form with a matrix material using any suitable technique such as soft lithography and/or molding. The coil form can be removed from the probe matrix leaving a void sample volume (28) in the probe matrix. Advantageously, the NMR probes of the present invention allow for fill-factors approaching and achieving 100%.Type: GrantFiled: January 4, 2007Date of Patent: September 18, 2012Assignee: University of Utah Research FoundationInventors: James C. Stephenson, Bruce K. Gale, Cynthia Furse
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Patent number: 8264225Abstract: A bore tube for use in an imaging apparatus has a first tube and a second tube. The first tube is a complete cylinder of electrically conductive material; and the second tube is segmented into separate elements, each separately attached to the first tube.Type: GrantFiled: July 22, 2011Date of Patent: September 11, 2012Assignee: Siemens PLCInventor: Marcel Jan Marie Kruip
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Publication number: 20120223716Abstract: A sample holder structure is provided with which it is possible to reduce current noise derived from electromagnetic induction, etc. in electricity-detection electron spin resonance spectroscopy. Also provided is a process for producing the structure. The material of the sample holder, which is used in an electricity-detection electron spin resonance device, is an FR-4 resin, alumina, glass, or Teflon. The sample holder has four wiring leads formed on the surface thereof. The four wiring leads each has a three-layer structure composed of a nickel layer, a gold layer, and a resist layer which have been arranged in the order from the sample holder surface, and the sample holder has the shape of the letter T. The sample holder has, formed in the end thereof, a gold pad for affixing a sample, and the gold pad has a multilayer structure composed of a nickel layer and a gold layer arranged in this order from the sample holder surface.Type: ApplicationFiled: October 1, 2010Publication date: September 6, 2012Inventors: Yoshiki Yonamoto, Naotoshi Akamatsu
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Publication number: 20120194194Abstract: A kit and methods of using including a package with at least one NMR tube comprising an elongate cylindrical body with an open proximal end and a band around an outside of the cylindrical body, the band positioned adjacent the open proximal end and having a width extending along a length of the elongate cylindrical body. The kit also including at least one closure configured to slidably engage the outside of the elongate cylindrical body so that when the closure is fully placed on the NMR tube, a distal end of the closure extends a length along the cylindrical body and is within about the width of the band.Type: ApplicationFiled: January 31, 2011Publication date: August 2, 2012Applicant: Norell, Inc.Inventor: Gregory B. Norell
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Patent number: 8217655Abstract: A transport device for conveying an object to be transported (18) between an input point (A) and a supply point (Z), where the object to be transported (18) can be supplied to an RT tube (4) of a cryostat (1), wherein the input point (A) is both horizontally and also vertically spaced apart from the supply point (Z), wherein a transport tube (14) is provided for pneumatically conveying the object to be transported within the transport tube (14) from a first transfer point (B) to a second transfer point (C), is characterized in that the transport tube (14) is vertically arranged, a first transport container (TB1) and a second transport container (TB2) are provided for receiving the object to be transported (18), a first transfer device is disposed between the input point (A) and the first transfer point (B), and a second transfer device is provided between the second transfer point (C) and the supply point (Z).Type: GrantFiled: December 15, 2009Date of Patent: July 10, 2012Assignee: Bruker BioSpin AGInventors: Jonathan De Vries, Daniel Guy Baumann, Oskar Schett, Werner Maas
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Patent number: 8212566Abstract: A sensor for sensing an angular position of an instrument relative to a static magnetic field includes a flexible beam, an electromagnetic device, and a measuring device. The beam at one end may be coupled to the instrument, and lies along a sensor axis when the beam is in a non -flexed state. The electromagnetic device is coupled to the beam and is configured for generating a magnetic sensor field aligned with the sensor axis. The measuring device communicates with the beam and is configured for measuring a property of the beam related to an amount of flexure of the beam. The sensor may be utilized to set the instrument at a desired angle prior to operating the instrument, and to determine whether the instrument has deviated from the desired angle during operation. The instrument may include a probe spinning module such as may be utilized in magnetic resonance experiments.Type: GrantFiled: July 24, 2009Date of Patent: July 3, 2012Assignee: Agilent Technologies, Inc.Inventor: Charles Glen Mullen
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Patent number: 8212559Abstract: A nuclear magnetic resonance (NMR) magic angle spinning (MAS) probe head (1; 61) for measuring a measuring substance in an MAS rotor (21a-21c), comprises a bottom box (3) and a tube (2) mounted to the bottom box (3) and projecting from the bottom box, wherein, in the area of the end (5) of the tube (2) facing away from the bottom box (3), an MAS stator (7; 62) is disposed within the tube (2) for receiving an MAS rotor (21a-21c), and with a pneumatic sample changing system for supplying and discharging an MAS rotor (21a-21c) to/from the MAS stator (7; 62). A transport conduit (10) is provided for pneumatically transferring an MAS rotor (21a-21c) within the transport conduit (10), wherein the transport conduit (10) extends in the inside of the tube (2) from the bottom box (3) to the MAS stator (7; 62). The probe head realizes fast change between different MAS rotors and facilitates RF shielding and keeping of defined extreme temperature conditions.Type: GrantFiled: October 13, 2009Date of Patent: July 3, 2012Assignee: Bruker BioSpin GmbHInventors: Martin Armbruster, Benno Knott
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Patent number: 8212565Abstract: Each NMR rotor bearing in an NMR magic angle spinning assembly is constructed of a porous ceramic material and has no inlet channels or nozzles. Instead, pressurized gas is forced through pores in the bearing ceramic material from an annular groove at the bearing periphery to the central aperture. Since the pores are small and very numerous, the gas pressure is effectively balanced around the periphery of the central aperture. In addition, if contaminants block one or more pores during operation, the pores are so numerous that the balanced pressure can still be maintained in the central aperture, thereby preventing an imbalance that could destroy the rotor.Type: GrantFiled: October 29, 2009Date of Patent: July 3, 2012Assignee: Bruker Biospin CorporationInventor: Eckhard Bez
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Publication number: 20120161770Abstract: Apparatuses, methods, and other embodiments associated with determining organ viability are described. According to one embodiment, an apparatus includes logic configured to apply nuclear magnetic resonance (NMR) energy to a kidney positioned in a hypothermic pulsative perfusion (HPP) apparatus. The NMR energy is produced according to an MRS 31P specific pulse sequence. The HPP apparatus has an integrated RF coil. The HPP may also have an integrated magnet. The RF coil is positioned and oriented to facilitate optimizing 31P MRS of the kidney. The apparatus also includes logic configured to receive spectrum data from the kidney. The spectrum data is produced in response to applying the NMR energy to the kidney. The apparatus also includes logic configured to provide objective, quantitative kidney viability data (e.g., PME/Pi, ATP/ADP) from the spectrum data. More generally, MRI/MRS compatible HPP apparatuses are configured to interact with dedicated NMR spectroscopy apparatuses.Type: ApplicationFiled: December 27, 2010Publication date: June 28, 2012Inventors: Hiroyuki FUJITA, John L. Patrick, Ronald B. Richard
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Patent number: 8203339Abstract: An apparatus comprising a magnetic field generator for generating a magnetic field of a predetermined orientation, an element provided in the apparatus at a location that, in use, is within a region of the magnetic field having the predetermined orientation generated by the generator, and a device for determining an angle between the element and the magnetic field, the device comprising a Hall Effect sensor.Type: GrantFiled: October 19, 2007Date of Patent: June 19, 2012Assignee: University of SouthamptonInventors: Ole Gustav Johannessen, Malcolm Harris Levitt
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Publication number: 20120146636Abstract: A high-pressure magic angle spinning (MAS) rotor is detailed that includes a high-pressure sample cell that maintains high pressures exceeding 150 bar. The sample cell design minimizes pressure losses due to penetration over an extended period of time.Type: ApplicationFiled: July 28, 2011Publication date: June 14, 2012Applicant: BATTELLE MEMORIAL INSTITUTEInventors: David W. Hoyt, Jesse A. Sears, JR., Romulus V. F. Turcu, Kevin M. Rosso, Jian Zhi Hu
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Publication number: 20120100546Abstract: This invention features systems and methods for the detection of analytes, and their use in the treatment and diagnosis of disease.Type: ApplicationFiled: October 22, 2010Publication date: April 26, 2012Applicant: T2 Biosystems, Inc.Inventors: Thomas Jay Lowery, JR., Mark John Audeh, Matthew Blanco, James Franklin Chepin, Vasiliki Demas, Rahul Dhanda, Marilyn Lee Fritzemeier, Isaac Koh, Sonia Kumar, Lori Anne Neely, Brian Mozeleski, Daniella Lynn Plourde, Charles William Rittershaus, Parris Wellman
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Patent number: 8153084Abstract: A sample tube for an NMR probe head, which extends along a z axis and has an internal cavity that extends in an axial direction of the z axis, is open to the outside at the axially upper end, is closed at the axially lower end and contains a liquid NMR sample substance during operation, wherein the cross-sectional surface of this cavity extending perpendicularly to the z axis and parallel to the xy coordinate plane has an elongated shape in the direction of the x axis with maximum dimensions a in the y direction and b in the x direction, wherein a<b, is characterized in that the cross-sectional surface of the sample tube, which extends perpendicularly to the z axis and is parallel to the xy coordinate plane has a circular outer shape. Sample tubes of this type provide a particularly large signal-to-noise ratio, can be easily inserted into a conventional cryogenic probe head and be axially and radially positioned therein by existing precision centering devices.Type: GrantFiled: November 24, 2006Date of Patent: April 10, 2012Assignee: Bruker BioSpin AGInventors: Philippe Stauffenegger, Oskar Schett
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Patent number: 8148989Abstract: An apparatus for increasing the ability to detect ferromagnetic objects by increasing the magnetization of the objects. The apparatus includes at least one coil to generate a magnetic field positioned in the area of the object to be detected. The apparatus includes an electrical energy storage capacitor bank capable of quickly releasing stored energy. The apparatus includes a high speed, high current electronic switch capable of quickly transferring the stored energy from the capacitor bank to the coil thereby producing in the coil a short duration, single polarity magnetic field pulse. The apparatus includes a sample and hold circuit capable of acquiring magnetic field sensor data during periods when the pulsed magnetic field is not present. The apparatus includes a microprocessor controller to control timing and sequence of the magnetic pulse generation and the sensor data sample and hold process. The apparatus may be for portal handheld or head mounted applications.Type: GrantFiled: January 27, 2009Date of Patent: April 3, 2012Inventor: Keith Kopp
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Publication number: 20120068710Abstract: A magnetic resonance device with a measurement chamber, an antenna arrangement that has a plurality of antenna elements arranged at least in certain areas around the measurement chamber, a gradient coil system arranged outside the antenna arrangement as seen from the measurement chamber, and a high-frequency shield system arranged between the antenna arrangement and the gradient coil system are provided. The high-frequency shield system has a reflector array with a plurality of passive reflector resonance circuits, each of which is configured such that resonance frequencies of the plurality of passive reflector resonance circuits lie below an operating magnetic resonance frequency of the magnetic resonance device and that the plurality of passive reflector resonance circuits has an inductive overall impedance.Type: ApplicationFiled: September 22, 2011Publication date: March 22, 2012Inventors: Stephan Biber, Jürgen Nistler, Markus Vester
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Publication number: 20120062226Abstract: Devices and related methods for nuclear magnetic resonance (NMR) analysis of particulate materials are provided including a detector chamber configured for insertion into an NMR spectrometer and configured to receive particulate materials in a fluid. A circulation chamber is attached to and in fluid communication with a first end of the detector chamber. A transition region is between the detector chamber and the circulation chamber, and a fluid supply interface is at a second end of the detector chamber that is configured to attach to a fluid source. The detector chamber, the circulation chamber and the transition region are sized and configured such that, when fluid flows from the fluid supply interface into the second end of the detector region, a circulating current is formed in the transition region and/or the circulation chamber such that the particulate matter is contained in the circulation chamber by the circulating current.Type: ApplicationFiled: March 31, 2010Publication date: March 15, 2012Inventors: Gary J. Pielak, Christopher Barnes, Naima G. Sharaf, Gregory Young, Freddy Pinero, Lisa Charltonl, Christopher Seagle
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Patent number: 8129991Abstract: Fixtures for immobilizing a patient during magnetic resonance imaging.Type: GrantFiled: September 15, 2005Date of Patent: March 6, 2012Assignee: Fonar CorporationInventors: Hugh Wahl, Arto Cinoglu, Cristian Balica, William H. Wahl
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Patent number: 8125224Abstract: A method of and miniaturized apparatus adapted for in-situ measurement of degradation of automotive fluids and the like by micro-electron spin resonance (ESR) spectrometry, wherein the use of a modulated constant magnetic field in an RF resonating variable frequency microwave cavity resonator through which a fluid sample is passed, enables direct detection of molecular changes in such fluid sample resulting from fluid degradation during use.Type: GrantFiled: December 9, 2008Date of Patent: February 28, 2012Assignee: Active Spectrum, Inc.Inventors: James R. White, Christopher J. White
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Patent number: 8106657Abstract: The present invention concerns an apparatus (1?) for NMR spectroscopy and/or NMR imaging of a sample. The apparatus comprises a static probe comprising an outer coil for excitation of nuclei of the sample by generating an incident radio frequency field at the Larmor frequency of the nuclei, and for reception of a return radio frequency field emitted by the sample, and a sensitive inner coil (6a?) which is mounted closely around or in contact with the sample container and which is wirelessly coupled to the outer coil by an electromagnetic radio frequency field. The sensitive inner coil is embedded in an inner spinning rotor (2) which is rotatively mounted inside the static probe and which is integral with the sample container, so that the filling factor and the radio frequency field amplitude in the sensitive coil are maximized.Type: GrantFiled: July 5, 2006Date of Patent: January 31, 2012Assignee: Commissariat a l'Energie AtomiqueInventors: Dimitrios Sakellariou, Jacques-François Jacquinot
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Patent number: 8106656Abstract: New MRI coil and resonators are disclosed based solely on superconducting inductive element and built-in capacitive elements as well as hybrid superconducting-metal inductive and capacitive elements having superior SNR. Single and multiple small animal MRI imaging units are also disclosed including one or more resonators of this invention surrounding one or more small animal cavities. Methods for making and using the MRI coils and/or arrays are also disclosed.Type: GrantFiled: November 18, 2010Date of Patent: January 31, 2012Assignee: The University of Houston SystemInventors: Jaroslaw Wosik, Krzysztof Nesteruk, Lei Ming P Xie
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Publication number: 20120007599Abstract: An upper stack for a nuclear magnetic resonance spectrometer apparatus includes a cryostat having one or more chambers for holding samples in a frozen state. A sample loading tube that also allows He delivery extends to the cryostat, and a sample changer mechanism is disposable at least in part proximate to the cryostat for moving specimens from the cryostat to an NMR probe where they can be heated and melted using inductive heating. A sample ejection tube extends from the sample changer mechanism allowing a clear path for heating a sample in an NMR probe using a laser beam.Type: ApplicationFiled: January 7, 2009Publication date: January 12, 2012Applicant: THE UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INCInventor: James H. Prestegard
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Patent number: 8093899Abstract: A magnetic field probe comprises a sample that exhibits magnetic resonance at an operating frequency, an electrically conductive structure surrounding the sample for receiving a magnetic resonance signal therefrom, and a solid jacket encasing the sample and the conductive structure. The jacket is made of a hardened two-component epoxy system containing a paramagnetic dopant dissolved therein, with the concentration of the dopant being chosen such that the jacket has a magnetic susceptibility that is substantially identical to the magnetic susceptibility of the conductive structure.Type: GrantFiled: April 19, 2007Date of Patent: January 10, 2012Assignee: Eidgenössische Technische Hochschule (ETH) and Universität ZürichInventors: Christoph Barmet, Nicola De Zanche, Klass Prüssmann
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Publication number: 20120001636Abstract: A shim coil assembly for positioning shim coils in a narrow gap between magnetic poles of miniature NMR devices around the magnetic center includes electric traces on multiple levels of printed circuit board layers in various, overlapping configurations. Mirror image shim coils can be connected in series in a symmetric sense or connected in series in a antisymmetric sense.Type: ApplicationFiled: June 28, 2011Publication date: January 5, 2012Inventors: John C. Price, Michael Steinbach, Chris Jonkman
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Patent number: 8067937Abstract: ESR imaging probe, system, and method are described. The probe is an ex-situ probe, the system comprises the probe and configured for operating the probe, and the method comprises detecting ESR from outside a resonator of the probe. An exemplary embodiment of a probe according to the invention comprises a cooled dielectric resonator, and one sided gradient coils. An exemplary embodiment of the system comprises source current that is configured to supply to the gradient coils currents of up to 100 A in pulses shorter than 1 ?sec.Type: GrantFiled: June 14, 2007Date of Patent: November 29, 2011Assignee: Technion Research & Development Foundation Ltd.Inventors: Aharon Blank, Lazar Shtirberg
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Patent number: 8063639Abstract: An NMR probe comprising an RF resonator 48 serves in a first mode for conventional sensitivity optimized studies of abundant samples at frequency ?0, and in a second mode for independent sensitivity optimized studies of micro sample quantities at frequency ?0 through use of a removably insertable self-resonant micro-coil 50 within the RF resonator 48 and closely surrounding a micro sample, that is preferably independently removably insertable within the micro-coil. The NMR probe exhibits an enhanced tuning range to resonate in its first mode and in the second mode to inductively couple to the self-resonant micro-coil 50 to induce self-resonance of the micro-coil 50 at ?0.Type: GrantFiled: July 31, 2009Date of Patent: November 22, 2011Assignee: Agilent Technologies, Inc.Inventor: Albert P. Zens
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Patent number: 8063640Abstract: A method for measuring an sample in an NMR spectrometer uses a coupling configuration (1; 30) comprising a coupling element (3) and a supply capillary (2), wherein the coupling element (3) has a funnel-shaped section (5) which clamps an end (6) of the supply capillary (2). An envelope capillary (10) is provided into which the supply capillary (2) is inserted, wherein the end (6) of the supply capillary (2) projects past an end (11) of the envelope capillary (10), and the end (11) of the envelope capillary (10) is also clamped in the funnel-shaped section (5).Type: GrantFiled: September 15, 2010Date of Patent: November 22, 2011Assignee: Bruker BioSpin GmbHInventors: Martin Hofmann, Thorsten Marquardsen
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Patent number: 8040132Abstract: A method and apparatus for identifying a sample in a container, provide for the container with the sample being disposed relative to a resonator, a high-frequency signal being coupled into the resonator for exciting a resonant mode of the resonator, the resonant electric field of the resonator penetrating part of the sample in the container, the resonance curve of at least one resonant mode being measured with and without the sample, and the sample being identified based on the determined change in the resonance frequency compared to a measurement without sample.Type: GrantFiled: September 24, 2007Date of Patent: October 18, 2011Assignee: Forschungszentrum Juelich GmbHInventors: Norbert Klein, Hans-Joachim Krause, Willi Zander
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Patent number: 8013608Abstract: A high-resolution NMR probe is offered which is simple in structure and can be fabricated at low cost. The inside of the probe is maintained in a vacuum to adiabatically isolate the inside from the outside. Liquid helium is sent into a first heat exchanger located immediately close to a measurement portion via the innermost region of a triple tube placed in the vacuum. The helium is evaporated in the exchanger to cool a transmit-receive coil and a variable capacitor. The evaporated helium gas is returned via the outermost region of the triple tube. At this time, a radiation shield placed in the vacuum is cooled by a second heat exchanger placed in the return path.Type: GrantFiled: June 19, 2009Date of Patent: September 6, 2011Assignee: JEOL Resonance Inc.Inventors: Kiyonori Takegoshi, Takashi Mizuno
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Publication number: 20110204894Abstract: An analysis system (1) for the analysis of a sample, comprises a gel permeation chromatograph (14) that is coupled with a nuclear magnetic resonance(=NMR) spectrometer. The chromatograph (14) has a gel permeation chromatography(=GPC) separating column system (6a) that is filled with porous particles (21). The GPC separating column system (6a) includes at least the one GPC separating column (6), the GPC separating columns (6) of the GPC separating column system (6a) having an overall combined internal volume of at least 45 cm3, preferably at least 100 cm3. The NMR spectrometer is configured as a low-field NMR spectrometer (8) with a permanent magnet system (9) for generating a B0 field of the NMR spectrometer. The low-field NMR spectrometer (8) comprises a shim system (10) with which homogeneity of the B0 field of 0.5 ppm or better, preferably 0.1 ppm or better, can be achieved in a right circular cylindrical sample volume (27) having a diameter of at least 5 mm and a length of at least 15 mm.Type: ApplicationFiled: February 14, 2011Publication date: August 25, 2011Inventors: Andreas Kamlowski, Thorsten Hofe, Markus Cudaj, Manfred Wilhelm, Gisela Guthausen
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Publication number: 20110199086Abstract: Provided is an open-type MRI apparatus comprising a pair of magnetic field generating means arranged to face each other across a space for imaging an object, static magnetic field generating means holding means for holding the pair of static magnetic field generating means at a predetermined interval, and a pair of tabular gradient magnetic coil structures arranged on the imaging space side of the static magnetic field generating means. The open-type MRI apparatus is characterized in that the individual tabular gradient magnetic coil structures are fixed on their individually facing static magnetic field generating means at a plurality of positions for suppressing the deformations, which occur in the gradient magnetic coil structures, by the Lorentz forces which act, when driving electric currents are fed to gradient magnetic coils, on the coil conductors.Type: ApplicationFiled: August 25, 2008Publication date: August 18, 2011Inventors: Munetaka Tsuda, Kenji Sakaisara
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Patent number: 7990148Abstract: An object of the present invention is to provide a cooled NMR probe including an antenna coil and capable of decreasing an operation temperature of the antenna coil by effectively cooling the antenna coil, thereby increasing detection sensitivity of an NMR signal. To attain this, a probe head according to the present invention includes a coil support member which supports the antenna coil, and a cooling member arranged around at least a portion of the coil support member, the cooling member providing a cooling space between the cooling member and the coil support member, the cooling space allowing a refrigerant to circulate therethrough. The cooling member is coupled to the coil support member such that the refrigerant flowing in the cooling space directly contacts an outer peripheral surface of the coil support member.Type: GrantFiled: August 10, 2007Date of Patent: August 2, 2011Assignee: Kobe Steel Ltd.Inventor: Takashi Miki
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Publication number: 20110156703Abstract: A hybrid MRI-particle-based therapy system can include as components both a particle radiation therapy system configured to apply a charged particle beam to a region of application in a predetermined direction and also a MRI system including a magnetic field generator for generating a magnetic field in an imaging volume which includes the region of application at the same time that the charged particle beam is applied. The MRI system can be configured with two torroidal magnets or a magnet having apertures to provide access to the region of application for the charged particle beam, and to provide a homogeneous magnetic field in the region of application of the charged particle beam. The particle beam can be positioned to pass through a relatively low-strength portion of the main magnetic B0 field of the MRI system. Related methods of image-guided therapy are also provided by embodiments of the present disclosure.Type: ApplicationFiled: December 31, 2009Publication date: June 30, 2011Inventor: John P. O'Connor
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Patent number: 7944208Abstract: A Magnetic Resonance Imaging System consisting of a magnet (10) with a U-shaped frame (15), whose pole faces define an open magnetic imaging area [R] for a patient, and a magnetic field generator (17) that is controlled to generate magnetic fields inside the magnetic imaging area; a transport system (30) associated with the magnet has a support structure (20) that defines a movement path through the magnetic imaging area. The transport system (30) also includes a bench (40) to support the patient. The transport system (30) can slide the bench (40) along the support structure so that the patient can be introduced into and extracted from the magnetic imaging area. The bench (40) may further include a non-reclinable support part (41) coupled to reclinable support parts (42 and 43) at opposing ends to allow the position of patient to be rotatably changed on the bench (40).Type: GrantFiled: November 24, 2008Date of Patent: May 17, 2011Assignee: Paramed Medical Systems, Inc.Inventors: Roberto Dutto, Marco Monaldi
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Patent number: 7940045Abstract: An in vitro method of determining an analyte concentration of a sample includes placing the sample into a low-field, bench-top time-domain nuclear magnetic resonance (TD-NMR) spectrometer. The NMR spectrometer is tuned to measure a selected type of atom. A magnetic field is applied to the sample using a fixed, permanent magnet. At least one 90 degree radio-frequency pulse is applied to the sample. The radio-frequency pulse is generally perpendicular to the magnetic field. The 90 degree radio-frequency pulse is removed from the sample so as to produce a decaying NMR signal. The decaying NMR signal is measured at a plurality of times while applying a plurality of 180 degree refocusing radio-frequency pulses to the sample. The analyte concentration is calculated from the plurality of measurements associated with the decaying NMR signal and a selected model.Type: GrantFiled: May 13, 2009Date of Patent: May 10, 2011Assignee: Bayer Healthcare LLCInventors: Scott E. Carpenter, Thomas P. Benson
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Patent number: 7924008Abstract: The present utility model discloses a patient table for a magnetic resonance system, said magnetic resonance system also comprises a body coil, and said patient table comprises a table board and supporting means for supporting said table board, which table board is located in said body coil, and said supporting means supports said table board in such a way that the table board has no contact with said body coil. By using said patient table according to the present utility model, it is possible to eliminate the vibration of the table board caused by the vibration of a gradient coil, thus improving the imaging quality.Type: GrantFiled: January 27, 2009Date of Patent: April 12, 2011Assignee: Siemens AktiengesellschaftInventors: Ke Cheng Liu, Xiao Guang Liu
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Publication number: 20110074424Abstract: An MRT acquisition can be simplified by a method, an MRT apparatus and a support, for example a cushion, for a magnetic resonance tomography examination, that has at least one positioning aid for a heel of the patient and that has at least one positioning aid for the head.Type: ApplicationFiled: September 14, 2010Publication date: March 31, 2011Inventor: Yvonne Candidus
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Patent number: 7915893Abstract: All critical circuit components, including the sample coils, are located along with the spinner assembly in a region that may be evacuated to high vacuum for thermal insulation and high-voltage operation. A hermetically sealed spinner assembly simultaneously satisfies the requirements of hermeticity, low total emissivity, rf compatibility, spinning performance, magnetic compatibility, and high filling factor by utilizing metal construction except for the central region near the rf sample coils. Hence, it is possible to maintain high vacuum in the region external to the MAS spinner assembly even over a broad range of bearing and drive gas temperatures. A bundle of optical fibers is provided for tachometry for spin rates up to 60 kHz. The use of alumina disc capacitors allows the noise contributions from the most critical capacitors to be reduced to a minor fraction of the total and simplifies high voltage operation.Type: GrantFiled: November 18, 2007Date of Patent: March 29, 2011Assignee: Doty Scientific, Inc.Inventors: Siddarth Shevgoor, F David Doty
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Patent number: 7906967Abstract: An apparatus includes a bore tube inside which an imaging space is formed to place a subject, a static field generating section which is placed outside the tube and generates a static field in the imaging space, a gradient field generating section which is placed between the tube and the static field generating section and generates a gradient field to superimpose on the static field, a cover which is mounted to a side end of the static field generating section and forms a vacuum space in a surrounding of the gradient field generating section together with the tube and the static field generating section, wherein the cover is fixed by fixation parts thereof to the static field generating section and a load of an air pressure to be applied on the cover at a different part from the fixation part is received by the static field generating section.Type: GrantFiled: August 8, 2008Date of Patent: March 15, 2011Assignees: Kaibushiki Kaisha Toshiba, Toshiba Medical Systems CorporationInventors: Ayumi Katsunuma, Kiyoshi Yamashita
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Patent number: 7906966Abstract: An antenna for magnetic resonance imaging. The antenna preferably comprises a base, a first coil and a second coil. The first coil is mounted to the base and oriented to form an opening for receiving a foot of a patient such that the first coil extends around the foot along a lengthwise direction and defines a first coil vector that is perpendicular to the lengthwise direction. The second coil is preferably mounted to the base and oriented to extend along a widthwise direction of the foot and preferably defines a second coil vector that is parallel to the length wise direction of the foot.Type: GrantFiled: November 22, 2006Date of Patent: March 15, 2011Assignee: Fonar CorporationInventor: Jan Votruba
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Patent number: 7898256Abstract: An NMR measurement apparatus adopts a circulation flow scheme using a sample solution containing a high molecular compound representing a measuring object and a low molecular compound solution containing a low molecular compound representing a ligand. The measurement apparatus comprises a mixing filter 32 for mixing the sample solution and the low molecular compound solution, a separation filter 34 for performing separation therebetween, a flow channel 1 through which the sample solution drained out of the separation filter 34 is injected to the mixing filter 32, a flow channel 2 through which the low molecular compound solution drained out of the separation filter 34 is injected to the mixing filter 32, and a flow channel 3 through which the mixture solution drained out of the mixing filter 32 is injected to the separation filter 34 by way of a reservoir 10.Type: GrantFiled: February 17, 2009Date of Patent: March 1, 2011Assignee: Hitachi, Ltd.Inventors: Isao Kitagawa, Michiya Okada, Kazuo Saitoh
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Patent number: 7884608Abstract: A radio frequency coil unit includes a plurality of surface coils and a distributing/combining unit. The plurality of surface coils are arranged in a body-axis direction. The distributing/combining unit distributes and combines reception signals output from the plurality of surface coils to generate a new reception signal.Type: GrantFiled: April 22, 2008Date of Patent: February 8, 2011Assignees: Kabushiki Kaisha Toshiba, Toshiba Medical Systems CorporationInventor: Kazuya Okamoto
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Patent number: 7884609Abstract: To provide an RF coil of an MRI apparatus and improve the irradiation efficiency and the reception sensitivity of a circular polarized magnetic field with a simple structure. An RF coil has a set of input/output terminals and two loops. The two loops are disposed and capacitors in the loops are adjusted so that the linearly polarized magnetic fields generated and detected by the loops are perpendicular to each other, and the combined magnetic field of the linearly polarized magnetic fields is a circular polarized magnetic field.Type: GrantFiled: February 27, 2008Date of Patent: February 8, 2011Assignee: Hitachi, Ltd.Inventors: Yoshihisa Soutome, Hideta Habara, Yoshitaka Bito