Abstract: Microparticles containing a core of therapeutic protein and a cortex of a biocompatible and biodegradable polymer, and methods of making and using the microparticles are provided. The extended release of a therapeutic protein from the microparticles in a physiological solution is demonstrated over an extended period of time.

Abstract: The present invention relates to a method for heat-treating water-absorbing polymeric particles at a temperature in the range of from 100 to 250° C. in a fluidized bed dryer under specifically adapted apparatus and method conditions, the use of a fluidized bed dryer for heat-treating water-absorbing polymeric particles in continuous or batch mode as well as to the heat-treated polymeric particles obtained by the method of the present invention.

Abstract: A vapor atmosphere spray dryer can include a closed-loop circuit having a dryer, a bag house filter system, a fan, and a heater system which are fluidly connected together for circulating a mass of superheated vapor therethrough. A centrifugal atomizer is disposed within the dryer. A feed system delivers a supply of feed slurry to the centrifugal atomizer which discharges a supply of atomized feed slurry in the dryer for combination with the circulated mass of superheated vapor within the dryer. The closed loop circuit is constructed such that the circulated mass of superheated vapor has an operating pressure of at least 1 psi which is generated by the evaporation of the fluid in the atomized feed slurry in the dryer resulting from the combination of the supply of atomized feed slurry and the circulated mass of superheated vapor.

Abstract: Apparatus and methods for the dispersion of material into a drying gas stream are disclosed. The material dispersion apparatus can have a nozzle and a venturi positioned downstream of the nozzle. The drying gas stream can be generated by pulse combustion dryer or by spray dryer and pass over at least a portion of the nozzle.

Abstract: An abrasive is fabricated to obtain sliding and grinding effects. In the abrasive, grinding particles are wrapped by a wrapping material. Various sizes and shapes of molds and micro components can be finely polished to obtain mirror-grade surfaces.

Abstract: Spray dried particles having specified aerodynamic characteristics are produced by atomizing a liquid feed and contacting the liquid feed with a drying gas, such as, for example, air or nitrogen. The humidity of the drying gas is controlled to a value, expressed, for instance, as dew point, which is known to produce particles having a specified tap density or aerodynamic diameter. Particles having a volume median geometric diameter greater than about 5 microns and a tap density less than about 0.4 g/cm3 are preferred.

Abstract: Small crystals are made by mixing a solution of a desired substance with an anti-solvent in a fluidic vortex mixer in which the residence time is less than 1s, for example 10 ms. The liquid within the fluidic vortex mixer (12) is subjected to high intensity ultrasound from a transducer (20, 22). The solution very rapidly becomes supersaturated, and the ultrasound can induce a very large number of nuclei for crystal growth. Small crystals, for example less than 5 ?m, are formed. The resulting suspension is treated so as to add or remove ingredients, and then spray dried using an atomizer tuned to create small droplets in such a way that each droplet should contain not more than one crystal. Crystal agglomeration is hence prevented.

Abstract: Conventional spray-drying methods are improved by incorporation of a pressure nozzle and a diffuser plate to improve the flow of drying gas and a drying chamber extension to increase drying time, such improvements leading to the formation of homogeneous solid dispersions of drugs in concentration-enhancing polymers.

Abstract: Processes for preparing alkali metal alkoxide granules and alkaline earth metal alkoxide granules of aliphatic, saturated or unsaturated, unbranched or branched alcohols, preferably having 1 to 12, in particular 1 to 6, carbon atoms. A preferred process for preparing the alkoxides utilizes fluidized-bed spray granulation.

Abstract: Spray dried particles having specified aerodynamic characteristics are produced by atomizing a liquid feed and contacting the liquid feed with a drying gas, such as, for example, air or nitrogen. The humidity of the drying gas is controlled to a value, expressed, for instance, as dew point, which is known to produce particles having a specified tap density or aerodynamic diameter. Particles having a volume median geometric diameter greater than about 5 microns and a tap density less than about 0.4 g/cm3 are preferred.

Abstract: Conventional spray-drying methods are improved by incorporation of a pressure nozzle and a diffuser plate to improve the flow of drying gas and a drying chamber extension to increase drying time, such improvements leading to the formation of homogeneous solid dispersions of drugs in concentration-enhancing polymers.

Abstract: In a compact combined spray drying and after-treatment apparatus having internal gas filters and an internal fluidized bed in the drying chamber and a fluidized bed in the after-treatment zone, pipe means are used for conducting a stream of particle-loaded gas formed in the after-treatment zone to suitable locations in the drying chamber without disturbing the normal operation of the drying chamber and the fluidized bed therein.

Abstract: Processes for preparing alkali metal alkoxide granules and alkaline earth metal alkoxide granules of aliphatic, saturated or unsaturated, unbranched or branched alcohols having 1 to 12, in particular 1 to 6, carbon atoms. A preferred process for preparing the alkoxides utilizes fluidized-bed spray granulation.

Abstract: Improved spray drying apparati, and methods of use thereof, have been developed. The spray drying equipment includes a primary drying chamber and a secondary drying apparatus which includes tubing having a length sufficient to increase the contact time between the drying gas and the droplets/particles to dry the particles to the extent desired, at a drying rate and temperature which would be too low to provide adequate drying without the secondary drying apparatus. The secondary drying apparatus increases the drying efficiency of the spray dryer system without increasing the drying rate, while minimizing loss in yield. Te secondary drying apparatus can include multiple secondary apparati, which are independently controlled for temperature and/or have different dimensions (cross-sectional areas and/or lengths), to allow for optimization of drying conditions.

Abstract: Reduction of moisture in harvested crop particles. Waste heat from an internal engine carried by a harvester is applied to the crop during the harvesting process. Microwave energy is applied to the crop, concurrently with application of the heat, or separately from it. The objective is to reduce the moisture to a level acceptable to a storage facility, or at least to reduce the cost of further reduction.

Abstract: A continuous process for the drying and gel formation of solvent-containing gel-forming polymers, in particular polysaccharide derivatives, by flash cooling of suspensions of the polymers, and an apparatus for the drying of solvent-containing products are described. The process comprises the steps: metering the solvent-containing polymer having a solids content of 1 to 65% by weight and at a pressure of in particular ambient pressure to 6000 hPa, at a polymer temperature of 20 to 100° C. into an evaporation zone (1), the evaporation zone (1) having a pressure of 0.1 hPa to 800 hPa, cooling the polymer, in particular to a temperature of <93° C.

Abstract: In a spray drying process utilizing a spray dryer having internal gas filters and an internal fluidized bed and comprising an after-treatment of the product in a separate unit outside the spray drying chamber, which treatment produces a particle-loaded gas stream, said particle-loaded gas stream is conducted from the separate unit to the spray drying chamber. The stream passes, together with the spent drying gas in the drying chamber, the filters integrated in said chamber. Several plant modifications are suggested for performing the process which involves substantial savings by making external particle collectors superfluous.

Abstract: A continuous process for the drying and gel formation of solvent-containing gel-forming polymers, in particular polysaccharide derivatives, by flash cooling of suspensions of the polymers, and an apparatus for the drying of solvent-containing products are described. The process comprises the steps: metering the solvent-containing polymer having a solids content of 1 to 65% by weight and at a pressure of in particular ambient pressure to 6000 hPa, at a polymer temperature of 20 to 100° C. into an evaporation zone (1), the evaporation zone (1) having a pressure of 0.1 hPa to 800 hPa, cooling the polymer, in particular to a temperature of <93° C.

Abstract: A continuous process for the drying and gel formation of solvent-containing gel-forming polymers, in particular polysaccharide derivatives, by flash cooling of suspensions of the polymers, and an apparatus for the drying of solvent-containing products are described. The process comprises the steps: metering the solvent-containing polymer having a solids content of 1 to 65% by weight and at a pressure of in particular ambient pressure to 6000 hPa, at a polymer temperature of 20 to 100° C. into an evaporation zone (1), the evaporation zone (1) having a pressure of 0.1 hPa to 800 hPa, cooling the polymer, in particular to a temperature of <93° C.

Abstract: Free-flowing solid particles are dried in a moving bed dryer by passing the particles adjacent to a heat exchanger plate containing a heated fluid while passing a dehumidified gas into the solid particles from a gas flow manifold in the heat exchanger plate.

Abstract: Improved spray drying methods of have been developed. The spray drying method includes use of a primary drying chamber and a secondary drying apparatus which includes tubing having a length sufficient to increase the contact time between the drying gas and the droplets/particles to dry the particles to the extent desired, at a drying rate and temperature which would be too low to provide adequate drying without the secondary drying apparatus. The secondary drying apparatus increases the drying efficiency of the spray dryer system without increasing the drying rate, while minimizing loss in yield. The ratio of the length of tubing to the length of the primary drying chamber is at least 2:1. The tubing diameter is substantially smaller than the diameter of the primary drying chamber, such that the particles move at higher velocity through the tubing to minimize product losses.

Abstract: Spray drying is performed at increased pressure whereby advantages are obtained as to product characteristics and production capacity. Particulate materials of an amorphous structure and non-dusting high-bulk density powders can be obtained.

Abstract: In a process and an apparatus (1) for spray drying or spray cooling of the so-called Filtermat.RTM. type, a more uniform product layer (7) is achieved by collecting and/or treating the product on a screen means (8, 14, 19) providing a pressure difference being at least 1.5, preferably from 1.5 to 30 and particularly from about 2 to about 20 times that provided by the product layer, when collected.

Abstract: In a method of drying a moist bulk material, such as sewage sludge, and treating the malodorous moisture-laden gas resulting from the drying process, the moisture-laden gas is introduced into waste water contained in a waste water clarifying basin of a waste water treatment plant. A system for carrying out the method includes a drying apparatus and at least one waste water basin of a waste water treatment plant, connected so that the moisture-laden gas emitted from the drying apparatus can be introduced, for example through an aerator, into the waste water. Thereby, the gas is cooled, demoisturized and deodorized, and moisture and volatile components are condensed and/or dissolved out of the gas into the waste water. The waste water is beneficially oxygenated, heated, and enriched with organic substances.

Abstract: A method for treating material comprising starch and starch-bearing products wherein the products are introduced to a thermal processor comprising a housing defining an inner wall surface, an inlet end, an outlet end, and an agitator rotatable within the housing adapted to direct the material into contact with the inner wall surface. The inner wall surface is heated and nozzles associated with the agitator are used for discharging fluid from the nozzles into contact with the material during rotation of the agitator. Heating to obtain treatment of the material is provided by contact with the inner wall surface and by controlling the fluid discharge from the nozzles to create turbulence for spreading the material over a broad surface area of the inner wall surface to enhance and render substantially uniform the heat exchange between the material, the fluid, and the inner wall surface, and to control mass transfer between the fluid and the material.

Abstract: In an apparatus for drying a moist material in a stream of drying gas the residence time is increased by inserting one or more perforated plates, above which fluidized particle layers are created, and through which a portion of the drying gas and material to be dried are passed, whereas the remaining part of the drying gas and material is by-passed said perforated plates. Improved drying capacity, heat economy and operational flexibility and decreased risk for heat damage of the material to be dried are obtained.

Abstract: The present invention is directed to drying and heating processes and to an apparatus incorporating a pulse combustion device that can be used in a drying system or in a heating system. In general, the apparatus includes a pulse combustion device for the combustion of a fuel to produce a pulsating flow of combustion products and an acoustic pressure wave. The pulse combustion device has a combustion chamber connected to at least one resonance tube. A resonance chamber surrounds at least a portion of the pulse combustion device and includes a nozzle downstream from the resonance tube. The nozzle accelerates the combustion products flowing therethrough and creates a pulsating velocity head. In a drying system, the nozzle exits into a drying chamber where the combustion products contact a feed stream.

Abstract: In a drying or cooling chamber (1) having a mainly cylindrical upper section (2) joining an underlying mainly conical or frusto-conical lower section (3), an inlet (6) for processing gas is provided at the upper end of the cylindrical section (2) and an outlet (7) for the processing gas at the lower or upper end of the chamber. Deposition of products on the inner surfaces of the chamber is minimized by injection by nozzle means (8) of at least one jet of pressurized gas at a high flow velocity but a low flow rate compared to the flow velocity and the flow rate of the processing gas at a level of the cylindrical section (2) remote from the processing gas outlet (7) and at a point close to a circumferential wall (9) of the cylindrical section (2).

Abstract: An arrangement for reducing the moisture content of sludge includes a spray dryer to which the sludge, a dispersion medium in the form of gas or vapor as well as hot gas can be supplied. The arrangement further includes a separating unit with solids discharge arranged following the spray dryer via a transfer line and a heater for raising the temperature level of the gas entering the separating unit, wherein the heater is arranged in a connecting line between the separating unit and the spray dryer.