Abstract: Some embodiments of the disclosure provide a diabetic retinopathy recognition system (S) based on fundus image. According to an embodiment, the system includes an image acquisition apparatus (1) configured to collect fundus images. The fundus images include target fundus images and reference fundus images taken from a person. The system further includes an automatic recognition apparatus (2) configured to process the fundus images from the image acquisition apparatus by using a deep learning method. The automatic recognition apparatus automatically determines whether a fundus image has a lesion and outputs the diagnostic result. According to another embodiment, the diabetic retinopathy recognition system (S) utilizes a deep learning method to automatically determine the fundus images and output the diagnostic result.

Abstract: A system and method for eye tracking includes receiving an input image including at least a portion of a person's retina, finding a spatial transformation between the input image and a reference image, the reference image including at least a portion of the person's retina and calculating a change in orientation of an eye of the person corresponding to the spatial transformation. A processor may calculate, from the change in orientation an orientation of the person's eye associated with the input image, a direction of gaze associated with the input image, a gaze target associated with the input image and/or a ray of gaze associated with the input image.

Abstract: Provided is a method for controlling a display apparatus. In the method, the display apparatus receives at least two pieces of data to be displayed from at least two terminals respectively, wherein the at least two pieces of data to be displayed include screen projection data and status parameters of the at least two terminals, and then displays the status parameter, and performs a screen projection based on the screen projection data.

Abstract: The invention provides methods of diagnosing neuropathic corneal pain by the detection of neuromas, such as micro-neuromas, on the cornea. The invention also features systems for detecting the presence of anatomical features located on an ocular tissue surface that may be a marker for neuropathic corneal pain. The systems feature an in vivo confocal microscope and a computer N programmed with a neural network to automate the analysis of the microscope images. The invention provides methods of using the system to identify a micro-neuroma in images collected of an ocular surface and methods of diagnosing neuropathic corneal pain and monitoring treatment of neuropathic corneal pain using a system of the invention.

Abstract: An information processing apparatus includes a processor configured to acquire an image obtained by imaging a space by one imaging device fixed in the space, specify, in the image, a two-dimensional coordinate of a bright spot indicating light emission of a light emitting device moving in the space, acquire output information output by the light emitting device, and specify a three-dimensional coordinate in the space of the light emitting device based on the output information and the two-dimensional coordinate.

Abstract: Disclosed herein are systems, methods, and devices for classifying ophthalmic images according to disease type, state, and stage. The disclosed invention details systems, methods, and devices to perform the aforementioned classification based on weighted-linkage of an ensemble of machine learning models. In some parts, each model is trained on a training data set and tested on a test dataset. In other parts, the models are ranked based on classification performance, and model weights are assigned based on model rank. To classify an ophthalmic image, that image is presented to each model of the ensemble for classification, yielding a probabilistic classification score—of each model. Using the model weights, a weighted-average of the individual model-generated probabilistic scores is computed and used for the classification.

Abstract: A near eye display system is provided. The near eye display system includes: a frame comprising a main body and two temple arms; at least one near eye sensor mounted on the main body and configured to measure user eye parameters; a first near eye display mounted on the main body and configured to form a first image projected on a first retina of a first eye; a second near eye display mounted on the main body and configured to form a second image projected on a second retina of a second eye; and a processing unit located at least at one of the two temple arms and configured to generate a display control signal based at least on the user eye parameters, wherein the display control signal drives the first near eye display and the second near eye display.

Abstract: Systems and methods for improved interferometric imaging are presented. One embodiment is a partial field frequency-domain interferometric imaging system in which a light beam is scanned in two directions across a sample and the light scattered from the object is collected using a spatially resolved detector. The light beam could illuminate a spot, a line or a two-dimensional area on the sample. Additional embodiments with applicability to partial field as well as other types of interferometric systems are also presented.

Abstract: An ophthalmic apparatus that includes an image capturing unit configured to capture a target part of a subject eye; a processor; and a memory storing computer-readable instructions therein. The computer-readable instructions, when executed by the processor, may cause the ophthalmic apparatus to execute: acquiring a first image of the target part captured at a first timing by the image capturing unit and a second image of the target part captured at a second timing different from the first timing; and combining the first image with the second image to generate one combined image of the target part.

Abstract: The technology described herein is directed to a fundus camera and, more specifically, to a fundus camera having a display that projects active visual alignment stimuli onto an eye of an examinee via one or more components of an optimal assembly. The active visual alignment stimuli are dynamically adjusted to guide an examinee toward optical alignment for fundus imaging.

Abstract: A retinal imaging system includes an eyepiece lens assembly, an image sensor, a dynamic fixation target viewable through the eyepiece lens assembly, and a controller coupled to the image sensor and the dynamic fixation target. The controller includes logic that causes the retinal imaging system to perform operations including: acquiring a first image of the eye, analyzing the first image to determine whether a misalignment between the eye and the eyepiece lens assembly is present; in response to determining the misalignment is present, adjusting a visual position of the dynamic fixation target to encourage the eye to rotate in a direction that compensates for the misalignment, and acquiring the retinal image of the eye after adjusting the visual position of the dynamic fixation target.

Abstract: A method for capturing biometric measurement data of a patient's eye, in which the fixation is monitored during the entire biometric measurement. Information in respect of the fixation is extracted, depending on the different recording modes, from already available or additionally captured recordings and/or data. Central retinal OCT scans with absolute fixation information and frontal images with relative fixation information with or without at least partial diffuse lighting are used. On the basis of this extracted fixation information, the subsequent evaluation only uses the captured biometric measurement data captured just before, at the same time as or just after frontal images with the correct fixation. The method can also be applied to different measurement tasks, in which use is made of different measurement modes and in which the alignment of the measurement object is important for the measurement results.

Abstract: In some embodiments, readily understandable information displays are provided to help an operator guide an eye of a subject into an eyebox of a retinal imaging system. In some embodiments, a three-dimensional position of the eye with respect to the retinal imaging system is determined, and an interface that includes a three-dimensional representation of the position of the eye with respect to the eyebox is generated. In some embodiments, the gaze direction may also be determined and presented in the interface, so that the operator can also prompt the subject to correct issues with incorrect gaze direction.

Abstract: A system, method, and apparatus for guiding a needle into a target location of a patient's body are provided. The system includes a planned needle guide trajectory and a guide for removable attachment to a smartphone. The guide includes at least one needle guiding aperture extending substantially perpendicularly to a screen of the smartphone. The needle guiding aperture defines an actual needle guide trajectory. An inclinometer application is running on the smartphone. The inclinometer application indicates to a user conformance of the actual needle guide trajectory to the planned needle guide trajectory.

Abstract: A visual sense examination device includes: a beam source that emits a visible beam and an invisible beam; a visible beam optical system that includes a first scanner scanning the visible beam; an invisible beam optical system that includes a second scanner scanning the invisible beam; a detector that detects the invisible beam reflected by a retina of a subject; a controller that performs a first control; a synthesizer that synthesizes the visible beam scanned by the first scanner and the invisible beam scanned by the second scanner; and wherein scanning angles of the visible beam by the first scanner and the invisible beam by the second scanner are substantially the same, and projectable ranges of the visible beam scanned by the first scanner and the invisible light scanned by the second scanner are substantially the same on the retina of the subject.

Abstract: A method of leakage-compensated global illumination comprises obtaining position data for at least one of a head or an eye of a user of a display system by an application processor, rendering image data for an image frame by the application processor based on the position data, modifying the image data to compensate for leakage associated with a global illumination by a display of the display system, and sending the image data to a display driver circuit of the display system for displaying the image frame on the display through the global illumination.

Abstract: An apparatus for recording and displaying a three-dimensional OCT video includes an OCT system and a data processing unit configured to combine OCT volumes recorded sequentially in time to form a combined OCT volume, to generate display data which facilitate the display of the combined OCT volume, to register a current OCT volume of the OCT volumes, to combine the registered current OCT volume with the previous combined OCT volume to generate an updated combined OCT volume, to carry out a check for combining the registered current OCT volume with the previous combined OCT volume and in respect of which volume regions of the current OCT volume have changed in comparison with the corresponding volume regions of the previous combined OCT volume, and only to combine those volume regions of the current OCT volume that have not changed with the corresponding volume regions of the previous combined OCT volume.

Abstract: Provided is an ophthalmic apparatus for examining an examinee's eye, including: an examination device configured to examine the examinee's eye; an approacher in the examination device, configured to approach the examinee; a detector configured to detect approach of the approacher to the examinee; and a controller configured to switch an operation mode between a first mode where an avoidance operation for avoiding the approach is performed and a second mode where the avoidance operation is not performed, upon the detector detecting the approach.

Abstract: The present invention is a lighting device attached to the front of a camera device, such as a smartphone, and connected to the camera device to produce an appropriate lighting environment for the acquisition of good quality animal nose pattern images by taking into consideration such factors and ambient lighting as well as the color of the nose.

Abstract: In an ophthalmic system of some embodiments, ophthalmic imaging apparatuses include slit lamp microscopes, and information processing system is connected to each ophthalmic imaging apparatus via a communication path. Each ophthalmic imaging apparatus is configured to acquire a three dimensional image by photographing a subject's eye, and transmit the three dimensional image to the information processing system. The information processing system is configured to receive the three dimensional image, store three dimensional images received, perform machine learning and/or data mining based on the three dimensional images, store knowledge acquired by the machine learning and/or data mining, and generate diagnosis support information by performing inference based on a three dimensional image of a subject's eye transmitted from one of the slit lamp microscopes knowledge stored in the knowledge storage.

Abstract: A line-of-sight measurement device includes: an imaging unit that images a face of a subject; a light illumination unit that illuminates light to an eye of the subject; a camera coordinate system eyeball center coordinate calculation unit that estimates coordinates of an eyeball center, from a face image imaged by the imaging unit; a pupil center calculation unit that estimates coordinates of an apparent pupil center, from a pupil center position on the face image; an eyeball position orientation estimation unit that calculates an optical axis vector toward the pupil center from the eyeball center on the basis of the coordinates of the eyeball center and the apparent pupil center; a corneal reflection image calculation unit that obtains coordinates of a corneal reflection image on the basis of the coordinates of the eyeball center, the optical axis vector, and a predetermined eyeball model; and an image coordinate calculation unit that estimates image coordinates of a corneal reflection image on the face imag

Abstract: Exemplary light control devices and methods provide a regional variation of visual information and sampling (“V-VIS”) of an ocular field of view that improves or stabilizes vision, ameliorates a visual symptom, reduces the rate of vision loss, or reduces the progression of an ophthalmic or neurologic condition, disease, injury or disorder. The V-VIS devices and methods generate a moving aperture effect anterior to a retina that samples and delivers to the retina environmental light from an ocular field of view at a sampling rate between 50 hertz and 50 kilohertz. Certain of these V-VIS devices and methods may be combined with augmented or virtual reality, vision measurement, vision monitoring, or other therapies including, but not limited to, pharmacological, gene, retinal replacement and stem cell therapies.

Abstract: Exemplary light control devices and methods provide a regional variation of visual information and sampling (“V-VIS”) of an ocular field of view that improves or stabilizes vision, ameliorates a visual symptom, reduces the rate of vision loss, or reduces the progression of an ophthalmic or neurologic condition, disease, injury or disorder. The V-VIS devices and methods generate a moving aperture effect anterior to a retina that samples and delivers to the retina environmental light from an ocular field of view at a sampling rate between 50 hertz and 50 kilohertz. Certain of these V-VIS devices and methods may be combined with augmented or virtual reality, vision measurement, vision monitoring, or other therapies including, but not limited to, pharmacological, gene, retinal replacement and stem cell therapies.

Abstract: Disclosed herein are devices and methods for generating stereoscopic views of the eye (or any desired anatomic structure) using a dual-camera portable computing device. The locations of the two cameras are fixed, and the camera lenses may have different focal lengths. For example, the focal length of the second camera lens may be longer than the focal length of the first camera lens. One variation of a detachable imaging system comprises an objective lens and a relay lens that are disposed over the two cameras. The relay lens may be disposed over the first and second cameras, and have a focal length that is greater than the focal length of the first camera lens and less than or equal to the focal length of the second camera lens.

Abstract: An image processing method, which is executed by a processor, comprises acquiring choroid information from an image of a fundus of an examined eye, and comparing the choroid information against a choroid normative database and determining whether or not there is an abnormality in the fundus.

Abstract: The present disclosure provides a system and method for maintaining the position of a suction cone on an eye during laser ophthalmic surgery that includes determining a distance and direction the suction cone or a support must be adjusted to maintain the position of the suction cone within an optimal working range, based on a detected position of the suction cone. The disclosure further provides a method for maintaining the position of a suction cone by determining a distance and direction the suction cone or a support must be adjusted to maintain the position of the suction cone within an optimal working range, based on a detected position of the suction cone. In the system and the method, a control signal is generated to adjust the position of the suction cone and/or the support to maintain the suction cone within the optimal working range.

Abstract: An eye measuring apparatus includes a stimulator including multiple stimulator light points for projecting a plurality of light rays onto a surface of the cornea of an eye; a camera system for capturing reflected images of the stimulator light points; and a computational unit arranged to analyse the posterior surface of the cornea and/or to obtain a characteristic of the eye on the basis of the reflected images. The control unit is arranged to activate subsequently different subsets of the multiple stimulator light points; and to carry out the following steps: selecting, for each of the different subsets of the multiple stimulator light points, at least one reflected image that corresponds with activation of the respective subset of the multiple stimulator light points, and combining the selected reflected images with each other to analyse the posterior surface of the cornea and/or to obtain the characteristic of the eye.

Abstract: An image processing device processes an image of a subject eye. The image processing device includes an image acquisition unit that acquires an image of the subject eye, a diagnosis unit that obtains a diagnosis result of the subject eye based on the image acquired by the image acquisition unit, and a display control unit that changes a display mode of a display unit based on the diagnosis result.

Abstract: Measuring fluorescence within a zone on a surface of biological tissue uses a probe that comprises first and second sensors that are constituents of corresponding first and second optical systems and that are fixed relative to each other. The first sensor is configured to detect fluorescent light emitted at said surface and the second sensor detects visible light. The measurement includes projecting a mark onto the zone, and, based on a position of an image of the mark on the second sensor, localizing and locating fluorescence detected by the first sensor in an image of the zone. The image is produced in visible light. The mark is a light mark that is detectable by said second sensor.

Abstract: An ophthalmologic apparatus includes a data acquisition unit, a movement mechanism, an image acquisition unit, an analyzer, and a controller. The data acquisition unit is configured to optically acquire data of a fundus of a subject's eye. The movement mechanism is configured to change relative position between the subject's eye and the data acquisition unit. The image acquisition unit is configured to acquire an image of the fundus. The analyzer is configured to specify at least one of a relative movement direction and relative movement amount of the data acquisition unit with respect to the subject's eye based on a flare region in the image and a reference position in the image. The controller is configured to control the movement mechanism based on the at least one of the relative movement direction and the relative movement amount.

Abstract: Performance of enhanced visually directed procedures under low ambient lighting conditions. An imaging system includes a first high resolution photosensor configured to acquire at least one first real-time high resolution video signal representing at least one view of the eye in at least one wavelength of light outside of the wavelengths of visible light. A second high resolution photosensor is configured to acquire at least one second real-time high resolution video signal representing the at least one view of the eye inside of the wavelengths of visible light. A control unit is configured to acquire the at least one first real-time high resolution video signal and the at least one second real-time high resolution video signal after the light conditions are low enough such that a pupil of the eye does not constrict substantially from its maximum pupillary diameter, via the first and the second high resolution photosensor, respectively.

Abstract: An ophthalmic device comprising a light source to emit fixation target light, and a reflecting face to reflect scanning light emitted by an emission section and scan the scanning light in a specific direction by changing orientation, the emission section being a scanning light source different to the light source. A concave mirror face is disposed so scanning light reflected by the reflecting face is incident on a subject's eye ocular fundus when the eye is at the concave mirror's focal point, and is arranged such that, when the eye is at the concave mirror's focal point, and when the light source emits fixation target light, that light and scanning light are simultaneously incident on the ocular fundus via different optical paths propagating via the concave mirror face and focal point, the target fixation light following a predetermined optical path for fixing the subject's eye gaze.

Abstract: An ophthalmological device according to one aspect of the present disclosure includes a support structure, an illumination light source, an observation optical system, and a controller. The support structure is configured to support a subject's face. The illumination light source is configured to illuminate a subject's eye. The observation optical system includes an imaging element configured to receive light reflecting off the subject's eye. The controller is configured to acquire, from the imaging element, a first image captured when the illumination light source is on and a second image captured when the illumination light source is off and determine whether the subject's face is placed on the support structure based on a difference between the first image and the second image.

Abstract: A fundus imaging apparatus acquires a fundus image based on a signal from a light receiving element that receives fundus reflection light of illumination light with which a fundus of a subject eye is irradiated through an objective lens. The fundus imaging apparatus includes an information acquisition unit that acquires information relating to a refractive power of a subject eye, and a process that executes an artifact suppressing process for suppressing occurrence of an artifact due to reflection of the illumination light at the objective lens. The processor switches an imaging mode based on the refractive power between an invalid mode in which the artifact suppressing process is not executed and a valid mode in which the artifact suppressing process is executed.

Abstract: A method including determining a maximum luminance location of a display based on a field of view of an eye of a user of the display, and driving a plurality of light sources in the display based on locations of the plurality of light sources with respect to the maximum luminance location of the display. The plurality of light sources is controlled to have different luminance levels in different display zones corresponding to different zones on the retina of the eye of the user. In some examples, the display zones of the display system that have higher luminance levels can be dynamically changed based on the field of view or the gaze direction of the eye of the user.

Abstract: An ophthalmologic apparatus includes a data acquisition unit, a movement mechanism, an image acquisition unit, an analyzer, and a controller. The data acquisition unit includes an optical system for optically acquiring data of a fundus of a subject's eye. The movement mechanism is configured to change relative position between the subject's eye and the data acquisition unit. The image acquisition unit is configured to acquire an image of the fundus. The analyzer is configured to specify a relative movement direction and relative movement amount of the data acquisition unit with respect to the subject's eye based on a flare region formed all around a fundus region in the image. The controller is configured to control the movement mechanism based on the relative movement direction and the relative movement amount to change relative position between the subject's eye and the data acquisition unit in an optical axis direction of the optical system.

Abstract: A technical object is to provide an ophthalmic apparatus and an ophthalmic apparatus control program that are capable of appropriately performing alignment in a wide range.

Abstract: A portable retinal imaging device for imaging the fundus of the eye. The device includes an ocular imaging device containing ocular lensing and filters, a fixation display, and a light source, and is configured for coupling to a mobile device containing a camera, display, and application programming for controlling retinal imaging. The light source is configured for generating a sustained low intensity light (e.g., IR wavelength) during preview, followed by a light flash during image capture. The ocular imaging device works in concert with application programming on the mobile device to control subject gaze through using a fixation target when capturing retinal imaging on the mobile device, which are then stitched together using imaging processing into an image having a larger field of view.

Abstract: A goggle type display device with a goggle-shaped frame and a display mounted on said frame includes: an image-capturing unit disposed inside of the frame; and an eye gaze position estimator that estimates an eye gaze position on the basis of images of an eye and a ridge of a nose included in a facial image captured by said image-capturing unit.

Abstract: An OCT apparatus includes an OCT optical system that splits light from an OCT light source into a measurement optical path and a reference optical path and detects a spectral interference signal between measurement light and reference light, an image processor that processes the spectral interference signal to acquire OCT data of an examinee's eye, an optical scanner that deflects the measurement light and performs scanning on tissue of the examinee's eye, and a light guiding optical system that includes an objective optical system curving a concentrating plane such that the concentrating plane has a convex shape toward a side of a fundus, and forms the concentrating plane of the measurement light in an anterior chamber.

Abstract: The invention provides a method of noninvasively treating a condition associated with reduced integrity or increased permeability of an epithelial layer by a series of magnetic pulses having a magnitude of up to 3 T, wherein the magnetic pulses are designed to induce an electric field having a magnitude of up to 250 Volt per meter adjacent to a target treatment area, the condition particularly being ocular condition associated with reduced barrier function of the cornea. The invention provides a device for effecting the tissue treatment, creating series of pulses exhibiting a rate of change of more than 200 T/s in the absolute value.

Abstract: The present disclosure relates to an optical coherence tomography (OCT) including: an OCT device, an OCT calculation method, and an OCT calculation program, enabling correlation between images to be easily performed; more specifically it relates to a case where a functional OCT image such as a motion contrast is acquired by using the OCT; acquiring the functional OCT image through a calculation process of an OCT signal is a time-consuming process, for this reason, a long time elapses until the point that a functional OCT image can be observed after OCT imaging is completed, and thus this causes stress to a subject and an examiner; the present disclosure provides an OCT device, an OCT calculation method, and an OCT calculation program, enabling a functional OCT image to be rapidly acquired and enables an examiner to easily perform diagnosis.

Abstract: System and method for providing diagnostic, imaging procedures and surgical laser treatments generating patterns of laser light on target tissue of a patient. The system includes aiming and treatment light beams originating from the same visible laser emitting diode, a scanner for generating patterns of points of light of the generated light, a controller, and a user interface that allows the user to select one of several possible point of light patterns, adjusts the point of light intensity and/or duration.

Abstract: Ophthalmic imaging devices and related methods employ self-alignment of a user with an optical axis of the imaging device. An ophthalmic imaging device includes an imaging assembly having an optical axis, a housing assembly, and a viewer assembly. The housing assembly is configured to rest on a horizontal surface during operation of the imaging assembly. The optical axis is oriented at an angle from 45 degrees to 85 degrees from the horizontal surface. The viewer assembly includes an interface surface shaped to engage a user's head to stabilize a position and an orientation of the user's head relative to the optical axis. The viewer assembly accommodates different positions and/or orientations of the user's head relative to the optical axis so as to enable alignment, by the user, of one of the user's eyes with the optical axis.

Abstract: A method, computer system, and computer program product for real-time pediatric eye health monitoring and assessment are provided. The embodiment may include receiving a plurality of real-time data related to an individual's eye health from a user device. The embodiment may also include assessing biometric indications relating to eye health based on the plurality of real-time data. The embodiment may further include generating a report on the assessed biometric indications. The embodiment may also include collecting clinical information from one or more databases. The embodiment may further include determining whether the assessed biometric indications reach pre-configured threshold conditions. The embodiment may also include generating alerts and recommendations based on analysis of the collected clinical information and the assessed biometric indications based on the assessed biometric indications satisfying the pre-configured threshold conditions.

Abstract: The technology described herein is directed to a fundus camera and, more specifically, to a fundus camera having a display that projects active visual alignment stimuli onto an eye of an examinee via one or more components of an optimal assembly. The active visual alignment stimuli are dynamically adjusted to guide an examinee toward optical alignment for fundus imaging.

Abstract: Diagnostic tool for eye disease detection using a smartphone. At least some of the example embodiments are methods including capturing, by way of a camera lens on a device, an image of an eye to create a raw specimen; processing the raw specimen to create a processes specimen; performing edge detection on the processed specimen to detect a boundary of a cornea; extracting a region of interest of the cornea; identifying a boundary of the region of interest using a boundary tracing technique to identify a second boundary; analyzing the second boundary of the region of interest, by measuring a slope of the second boundary; and classifying the region of interest as including an eye disease, based on the analyzing the second boundary.

Abstract: According to some embodiments, a system and method of determining visual acuity is disclosed. The system and method of determining visual acuity comprises initiating a visual acuity test on a first computing device, linking a program on a second computing device with the visual acuity test on the first computing device, determining a distance from the first computing device using the second computing device, and transmitting answers to the visual acuity test using the second computing device wherein the questions associated with the visual acuity test are displayed on the first computing device.

Abstract: This disclosure provides a pupil localization method, a device, an apparatus and a storage medium. The method comprises: preprocessing a pupil image; generating a first projection curve and a second projection curve on horizontal and vertical axes of two-dimensional coordinate axes respectively according to the preprocessed image; determining a first pair of dividing points and a second pair of dividing points on the first projection curve and the second projection curve respectively according to a pre-configured threshold; and determining center coordinates of the pupil according to the first pair of dividing points and the second pair of dividing points. This disclosure obtains projection curves through a simple operation of the preprocessed image on the two-dimensional coordinate axes, and then intercepts the dividing point on the projection curves according to the preconfigured threshold to determine the center coordinates of the pupil.

Abstract: The present invention provides an ophthalmic device capable of minimizing the generation of flare at a lower cost and in a shorter time than in the prior arts when photographing in a state where an optical axis of an examination optical system is deviated from a reference position of a subject eye.