Including Eye Photography Patents (Class 351/206)
  • Patent number: 11917167
    Abstract: The present disclosure provides an image compression method, including steps of: acquiring a human-eye fixation point on an original image, and determining a fixation region and a non-fixation region of the original image according to the human-eye fixation point; and compressing the non-fixation region, and generating a compressed image according to the fixation region and the compressed non-fixation region. The present disclosure also provides an image display method, an image compression apparatus, an image display apparatus, and a computer readable medium.
    Type: Grant
    Filed: May 8, 2021
    Date of Patent: February 27, 2024
    Assignees: BEIJING BOE OPTOELECTRONICS TECHNOLOGY CO., LTD., BOE TECHNOLOGY GROUP CO., LTD.
    Inventors: Zhihua Ji, Tiankuo Shi, Xiaomang Zhang, Chingwen Kung, Rui Liu, Yifan Hou, Minglei Chu, Yanhui Xi, Yan Sun, Chenxi Zhao, Xiangjun Peng, Shuo Zhang
  • Patent number: 11900533
    Abstract: An image signal output method including outputting a first image signal to display an eyeball model selection screen for selecting one eyeball model from out of plural eyeball models of different types, converting a two-dimensional fundus image of the subject eye so as to generate a three-dimensional fundus image based on a selected eyeball model, and outputting a second image signal to display a fundus image display screen including the three-dimensional fundus image.
    Type: Grant
    Filed: October 11, 2018
    Date of Patent: February 13, 2024
    Assignee: NIKON CORPORATION
    Inventor: Mariko Hirokawa
  • Patent number: 11896309
    Abstract: A common beam scanning retinal imaging system comprises: a light source module (1), an adaptive optics module (2), a beam scanning module (3), a small field-of-view relay module (5), a large field-of-view relay module (6), a sight beacon module (9), a pupil monitoring module (7), a detection module (8), a control module (10) and an output module (11). The system can perform real-time correction of human eye aberration by adaptive optics technology, and realize the confocal scanning imaging function in a large field of view and the adaptive optics high-resolution imaging function in a small field of view simultaneously by the common beam synchronous scanning configuration combined with the two relay optical path structures for both the small field of view and the large field of view. The system can not only observe disease lesions in a wide range on the retina by the large field-of-view imaging, but also observe fine structures of the lesions by the small field-of-view high-resolution imaging.
    Type: Grant
    Filed: October 22, 2019
    Date of Patent: February 13, 2024
    Assignee: SUZHOU INSTITUTE OF BIOMEDICAL ENGINEERING AND TECHNOLOGY, CHINESE ACADEMY OF SCIENCES
    Inventors: Yi He, Guohua Shi, Feng Gao, Wen Kong, Lina Xing, Wanyue Li, Jing Wang, Xin Zhang
  • Patent number: 11890053
    Abstract: Improved optical coherence tomography systems and methods to measure thickness of the retina are presented. The systems may be compact, handheld, provide in-home monitoring, allow the patient to measure himself or herself, and be robust enough to be dropped while still measuring the retina reliably.
    Type: Grant
    Filed: March 3, 2023
    Date of Patent: February 6, 2024
    Assignee: ACUCELA INC.
    Inventors: Lukas Scheibler, Matthias Pfister, Urban Schnell, Stefan Troller, Ryo Kubota
  • Patent number: 11872162
    Abstract: Methods and apparatus are configures to measure an eye without contacting the eye with a patient interface, and these measurements are used to determine alignment and placement of the incisions when the patient interface contacts the eye. The pre-contact locations of one or more structures of the eye can be used to determine corresponding post-contact locations of the one or more optical structures of the eye when the patient interface has contacted the eye, such that the laser incisions are placed at locations that promote normal vision of the eye. The incisions are positioned in relation to the pre-contact optical structures of the eye, such as an astigmatic treatment axis, nodal points of the eye, and visual axis of the eye.
    Type: Grant
    Filed: August 18, 2022
    Date of Patent: January 16, 2024
    Assignee: AMO Development, LLC
    Inventors: David D. Scott, Javier Gonzalez, David Dewey, Noah Bareket, Georg Schuele
  • Patent number: 11871994
    Abstract: The object of the present invention is to develop an ophthalmologic microscope of a new method that increases the degree of freedom in the optical design in the Galilean ophthalmologic microscope provided with an OCT optical system. The present invention provides an ophthalmologic microscope, wherein an observation optical system, an objective lens, and an OCT optical system are placed in such a way that the optical axis of the OCT optical system does not penetrate through objective lens, and the optical axis of the observation optical system and the optical axis of the OCT optical system are non-coaxial, and wherein the ophthalmologic microscope further comprises a SLO optical system that scans a light ray which is a visible ray, a near infrared ray, or an infrared ray and guides the light to the subject's eye so as to become substantially coaxial with the optical axis of the OCT optical system.
    Type: Grant
    Filed: October 5, 2021
    Date of Patent: January 16, 2024
    Assignee: Topcon Corporation
    Inventors: Yasufumi Fukuma, Kazuhiro Oomori
  • Patent number: 11850001
    Abstract: Meta-lens based ocular imaging, near-eye display, and eye-tracking systems are described. The systems can include a single focusing optic and an integrated circuit that provides illumination light and includes an imaging array. The focusing optic includes meta-atoms formed on a substrate. The systems may have no moving parts and achieve imaging or image-projection fields-of-view approaching or exceeding 180 degrees. Because of their low part count, the systems can be robust and have a very small form factor.
    Type: Grant
    Filed: December 20, 2021
    Date of Patent: December 26, 2023
    Assignee: Massachusetts Institute of Technology
    Inventors: Juejun Hu, Tian Gu, Mikhail Shalaginov, Fan Yang
  • Patent number: 11832885
    Abstract: A physician prescribes an ocular imaging unit to a patient, which the patient sets up in the home to self-monitor his/her ocular anatomy. Typically, the unit connects to a smartphone, and the patient can use an app to operate the system. When the patient experiences a problem with his/her eyes, the patient initiates a remote evaluation, and the system transmits an alert to a remotely located physician, signifying the need for a pre-diagnostic evaluation. The physician then performs an initial evaluation remotely over the Internet using the home ocular imaging unit to obtain images or live video of the patient's ocular anatomy. The physician remotely makes a pre-diagnostic assessment regarding whether an in-person diagnostic examination of the ocular anatomy is warranted, and then communicates this to the patient. In some cases, the imaging unit captures images, both of the retinas and exteriors of the eyes, and also performs vision tests.
    Type: Grant
    Filed: October 26, 2020
    Date of Patent: December 5, 2023
    Assignee: Sanovas Intellectual Property, LLC
    Inventor: Jerry Katzman
  • Patent number: 11800977
    Abstract: A system for obtaining optical coherence tomography of the optical system of a person, comprising: an eyepiece customized for alignment and positioning to contact a person's eye socket and having a lens pocket for receiving a refractive lens customized for the person's eye refraction characteristics; a condensing system for receiving light from the eyepiece; a scanning module optically connected to the condensing system and having a mirror tiltable in two directions for obtaining optical scanning data from the person's optical system; and a spectrometer and camera module optically connected to the scanning module for obtaining and storing the optical scanning data, wherein the eyepiece, condensing system and scanning module are arranged to provide an optical path for delivering a light beam to the person's eye, and receive reflected light to be directed to the scanning module.
    Type: Grant
    Filed: October 31, 2018
    Date of Patent: October 31, 2023
    Assignee: OCTHealth, LLC
    Inventors: Steven Verdooner, John Rogers
  • Patent number: 11786121
    Abstract: Systems and methods for use in measuring sympathetic nervous system activity or blood vessel autoregulation corrected for sympathetic activity. The choroid in the human eye is imaged and, using the resulting image, the vascular perfusion density (VPD) in the choroid is measured. VPD provides a measurement that is directly related to sympathetic nervous system activity. The effect of stimuli on sympathetic nervous system activity can be measured by comparing pre-stimuli VPD measurements with post-stimuli measurements. Quantifying VPD can be performed by determining pixel density within specific areas of the choroid image. Altered sympathetic nervous system activity can be detected in a subject by comparing that subject's VPD measurements to baseline VPD measurements from healthy individuals. Blood vessel autoregulation can be measured by imaging changes in other blood vessels in the eye and correcting with choroid VPD measurements of sympathetic activity.
    Type: Grant
    Filed: May 3, 2018
    Date of Patent: October 17, 2023
    Inventors: Richard Wilson, Nicholas Jendzjowsky, Robert Herman, Willis Tsai, Fiona Costello, Craig Steinback
  • Patent number: 11779206
    Abstract: An OCT axial length measurement device is configured to measure an area of the retina within a range from about 0.05 mm to about 2.0 mm. The area can be measured with a scanned measurement beam or plurality of substantially fixed measurement beams. The OCT measurement device may comprise a plurality of reference optical path lengths, in which a first optical path length corresponds to a first position of a cornea, and a second optical path length corresponds to a second position of the retina, in which the axial length is determined based on a difference between the first position and the second position. An axial length map can be generated to determine alignment of the eye with the measurement device and improve accuracy and repeatability of the measurements. In some embodiments, the OCT measurement device comprises a swept source vertical cavity surface emitting laser (“VCSEL”).
    Type: Grant
    Filed: September 28, 2022
    Date of Patent: October 10, 2023
    Assignee: ACUCELA INC.
    Inventors: Ryo Kubota, Philip M. Buscemi, Matthias Pfister, Stephan Wyder, Amitava Gupta
  • Patent number: 11771317
    Abstract: Ocular surface interferometry devices, systems, and methods are disclosed for imaging an ocular tear film. An imaging device can be focused on the lipid layer of the tear film to capture optical wave interference interactions of specularly reflected light from the tear film combined with a background signal(s) in a first image, wherein the specularly reflected light may be produced from various portions of the ocular tear film by obliquely illuminating various portions of the ocular tear film with a multi-wavelength light source, such as in a tiling pattern(s). The imaging device can also be focused on the lipid layer to capture a second image containing the background signal(s) present in the first image. The second image can be subtracted from the first image to reduce and/or eliminate the background signal(s) in the first image to produce a resulting image, which can used to measure a tear film layer thickness.
    Type: Grant
    Filed: January 12, 2022
    Date of Patent: October 3, 2023
    Assignee: Tearscience, Inc.
    Inventors: Donald R. Korb, William L. Weber, Randal B. Chinnock, Benjamin T. Gravely, Stephen M. Grenon
  • Patent number: 11766170
    Abstract: A system for imaging a retina includes an optical relay system having a first lens for positioning proximate to an eye, a light source positioned to illuminate the eye, an image sensor positioned to capture a retinal image of the retina through the first lens, an aperture disposed between the image sensor and the first lens along an optical path extending from the image sensor through the first lens, and a processing apparatus. The aperture surrounds the optical path and is adapted to block off-axis reflections from the eye.
    Type: Grant
    Filed: September 29, 2021
    Date of Patent: September 26, 2023
    Assignee: Verily Life Sciences LLC
    Inventors: Dhruv Lamba, Sam Kavusi
  • Patent number: 11763490
    Abstract: Method of aligning an imaging device with respect to an object, the imaging device comprising two or more optical channels, is disclosed. The method may include aiming the two or more optical channels at corresponding overlapping zones of the object such that the two or more optical channels are oriented at different angles relative to each other and off-axis relative to a central axis of the imaging device. The method may additionally include guiding or focusing the imaging device relative to the object using composite images created by combining separate images from the two or more optical channels.
    Type: Grant
    Filed: July 23, 2020
    Date of Patent: September 19, 2023
    Assignee: Optos plc
    Inventors: Brendan Hamel-Bissell, Benjamin Adam Jacobson, Clint Suson, Clark Pentico, Andre E. Adams, Tushar M. Ranchod
  • Patent number: 11737665
    Abstract: Aspects of the present disclosure provide improved techniques for imaging a subject's retina fundus. Some aspects relate to an imaging apparatus that may be substantially binocular shaped and/or may house multiple imaging devices configured to provide multiple corresponding modes of imaging the subject's retina fundus. Some aspects relate to techniques for imaging a subject's eye using white light, fluorescence, infrared (IR), optical coherence tomography (OCT), and/or other imaging modalities that may be employed by a single imaging apparatus. Some aspects relate to improvements in white light, fluorescence, IR, OCT, and/or other imaging technologies that may be employed alone or in combination with other techniques. Some aspects relate to multi-modal imaging techniques that enable determination of a subject's health status.
    Type: Grant
    Filed: June 19, 2020
    Date of Patent: August 29, 2023
    Assignee: Tesseract Health, Inc.
    Inventors: Tyler S. Ralston, Maurizio Arienzo, Owen Kaye-Kauderer, Benjamin Rosenbluth, Jonathan M. Rothberg, Lawrence C. West, Paul E. Glenn
  • Patent number: 11730363
    Abstract: Improved optical coherence tomography systems and methods to measure retinal data are presented. The systems may be compact, provide in-home monitoring, and have automation to allow the patient to measure himself or herself.
    Type: Grant
    Filed: September 2, 2020
    Date of Patent: August 22, 2023
    Assignee: ACUCELA INC.
    Inventors: Ryo Kubota, Philip M. Buscemi
  • Patent number: 11726325
    Abstract: Disclosed in the present application are a near-eye optical imaging system, a near-eye optical imaging system based near-eye display device, and a near-eye display device based head-mounted display device. The near-eye optical imaging system comprises: a display, a first array of microlenses, which comprises a plurality of first microlenses; a second array of microlenses, which is arranged side by side with the first array of microlenses. The plurality of first microlenses in the first array of microlenses correspond to the plurality of second microlenses in the second array of microlenses respectively to form multiple optical channels. According to the present invention, an object located within a near-eye range is imaged by means of using a display, and two microlens arrays in concatenation.
    Type: Grant
    Filed: March 23, 2020
    Date of Patent: August 15, 2023
    Inventor: Jing Jiang
  • Patent number: 11706484
    Abstract: A video-processing method includes: obtaining a video frame rate of received video data; determining whether the video frame rate is less than the refreshing frame rate of a screen; and if yes, modifying at least one of the video frame rate of the video data or the refreshing frequency, so that the video frame rate of the video data is greater than or equal to the refreshing frame rate after modification. According to the present application, the effect that the video frame rate of a video file is greater than or equal to the refreshing frequency of the screen can be guaranteed, thus images corresponding to the video file can be displayed when the screen is refreshed, thereby avoiding standstill phenomena of video playback.
    Type: Grant
    Filed: May 20, 2021
    Date of Patent: July 18, 2023
    Assignee: GUANGDONG OPPO MOBILE TELECOMMUNICATIONS CORP., LTD.
    Inventor: Lizhong Wang
  • Patent number: 11690513
    Abstract: A sensor, such as a photoplethysmography sensor, for non-invasively monitoring a characteristic of an organism, such as a vital body sign. The sensor has multiple light sources disposed on a substrate and an array of optical probing channels for conveying light from the light sources to a probed region. Each detector pixel of an array of detector pixels receives light from a respective optical detection channel after interaction with a subregion of the probed region and spatial filtering, and generates a corresponding pixel signal.
    Type: Grant
    Filed: February 13, 2018
    Date of Patent: July 4, 2023
    Assignee: Massachusetts Institute of Technology
    Inventors: Juejun Hu, Tian Gu
  • Patent number: 11666212
    Abstract: A method and system are proposed for imaging the retinal structure of an eye. A light source is provided and a repetitive pattern is projected on the retina by said hght source having illuminated and non-illuminated portions with a spatial frequency larger than 0.5 mm-1. For the illuminated and non-illuminated portions a fluorescence level is measured; and a fluorescence level is derived as a corrected value for illuminated and non-illuminated areas.
    Type: Grant
    Filed: November 24, 2017
    Date of Patent: June 6, 2023
    Assignee: Nederlandse Organisatie voor toegepast-nataurwetenschappelijk onderzoek TNO
    Inventors: Arjen Amelink, Fokko Pieter Wieringa, Michiel Peter Oderwald
  • Patent number: 11670066
    Abstract: An example embodiment includes: a determination unit that, based on an image including an eye of a recognition subject, determines whether or not a colored contact lens is worn; and a matching unit that, when it is determined by the determination unit that the colored contact lens is worn, performs matching of the iris by using a feature amount extracted from a region excluding a predetermined range including an outer circumference of the iris out of a region of the iris included in the image.
    Type: Grant
    Filed: February 23, 2022
    Date of Patent: June 6, 2023
    Assignee: NEC CORPORATION
    Inventors: Mamoru Inoue, Jinit Bhatt
  • Patent number: 11653830
    Abstract: A multi-view diagnostic system includes an OCT engine and a plurality of optical elements defining a plurality of beam paths between the OCT engine and an ophthalmic target, with each beam path corresponding to a different viewing angle of the ophthalmic target. The system also includes a scanner to direct OCT imaging beams generated by the OCT engine toward the ophthalmic target along each respective beam path. Instructions stored in memory are executable by a processor to determine a characteristic of the ophthalmic target based on OCT light reflected by the ophthalmic target along each respective beam path and detected by the OCT engine.
    Type: Grant
    Filed: December 7, 2018
    Date of Patent: May 23, 2023
    Assignee: Alcon Inc.
    Inventors: Martin Gründig, Peter Zieger
  • Patent number: 11627874
    Abstract: Improved optical coherence tomography systems and methods to measure thickness of the retina are presented. The systems may be compact, handheld, provide in-home monitoring, allow the patient to measure himself or herself, and be robust enough to be dropped while still measuring the retina reliably.
    Type: Grant
    Filed: February 10, 2021
    Date of Patent: April 18, 2023
    Assignee: ACUCELA INC.
    Inventors: Lukas Scheibler, Matthias Pfister, Urban Schnell, Stefan Troller, Ryo Kubota
  • Patent number: 11596302
    Abstract: Disclosed is an eye examination apparatus for use with a smartphone. The eye examination apparatus has a body having a first eye opening and a second eye opening for a user to see into the eye examination apparatus using two eyes. In accordance with an embodiment of the disclosure, the eye examination apparatus has a coupling for receiving a smartphone having a display and a camera and for holding the smartphone in a predefined position in relation to the body, such that the camera of the smartphone is positioned to acquire ophthalmic images through the first eye opening, and the display of the smartphone is viewable through the second eye opening. In this manner, it is possible for the user to have an eye examination performed remotely outside of a clinician's office without specialized equipment by instead using their own smartphone.
    Type: Grant
    Filed: May 10, 2022
    Date of Patent: March 7, 2023
    Assignee: Neuroptek Corporation Inc.
    Inventors: Behzad Mansouri, Neda Anssari
  • Patent number: 11589745
    Abstract: Embodiments of the invention include a method to determine a binocular alignment, the method comprising: measuring a disassociated phoria of a first eye and a second eye of a patient at an apparent distance; and determining an accommodative convergence of the first eye and the second eye at the apparent distance using the measured disassociated phoria. In other embodiments, a system to determine a binocular alignment comprises a stereo display, for a projection of images for a first eye and a second eye; an accommodation optics, to modify the projection of the images according to an apparent distance; an eye tracker, to track an orientation of the first eye and the second eye; and a computer, coupled to the stereo display, the accommodation optics and the eye tracker, to manage a determination of the binocular alignment.
    Type: Grant
    Filed: September 23, 2019
    Date of Patent: February 28, 2023
    Assignee: Neurolens, Inc.
    Inventors: Jeffrey P. Krall, Aric Plumley
  • Patent number: 11583179
    Abstract: Sensor data is captured with a sensor. The sensor data includes a lens-position of a prescription lens relative to a reference point of an optical coherence tomography (OCT) system. A mirror of a reference arm of the OCT system is positioned at an optical pathlength between an eye region of the prescription lens based at least in part on the sensor data. An OCT signal is generated while the mirror is positioned at the optical pathlength. At least one depth profile is generated that includes the prescription lens and the eye region.
    Type: Grant
    Filed: July 2, 2020
    Date of Patent: February 21, 2023
    Assignee: Meta Platforms Technologies, LLC
    Inventors: Ruobing Qian, Mohamed Tarek El-Haddad, Robin Sharma
  • Patent number: 11571123
    Abstract: An ophthalmologic processing apparatus according to embodiments acquires data of a fundus of a subject's eye optically. The ophthalmologic apparatus includes a fixation system, an image acquisition unit, a specifying unit, and a determination unit. The fixation system is configured to project fixation light onto an eye of a subject. The image acquisition unit is configured to acquire an image of the fundus of the subject's eye in a state where the fixation light is projected by the fixation system. The specifying unit is configured to analyze the image acquired by the image acquisition unit to specify an image region corresponding to a predetermined site of the fundus. The determination unit is configured to determine whether or not the image region specified by the specifying unit is included within a predetermined range in the image acquired by the image acquisition unit.
    Type: Grant
    Filed: May 28, 2020
    Date of Patent: February 7, 2023
    Assignee: TOPCON CORPORATION
    Inventor: Yusuke Ono
  • Patent number: 11564568
    Abstract: An eye imaging system can include a head-wearable fundus camera positioning helmet with an outer shell and a conformable liner that can include head location fiducials defining a specified plane. An attached articulating fundus camera fixture can include a fundus camera positioning indication system to indicate a position of the fundus camera with respect to an eye of the patient for acquiring one or more fundus camera images at the indicated position such that fundus camera images recorded over a chronic period of time are assessable using the position information from the fundus camera positioning indication system. The articulating fundus camera fixture can include an articulating arm and a fundus camera mount. The system can assist the patient with helmet positioning, and can automatically position the fundus camera for accurate image capture and analysis, such as using a trained machine learning model for patient evaluation, monitoring, or diagnosis.
    Type: Grant
    Filed: May 25, 2022
    Date of Patent: January 31, 2023
    Assignee: Agnya Perceptive Solutions, L.L.C.
    Inventors: Sanjiv Bhatt, Saurin Shah, Dmitriy Yam
  • Patent number: 11559202
    Abstract: System for integrally measuring clinical parameters of the visual function including a display unit (20) for representing a scene with a 3D object having variable characteristics such as virtual position and virtual volume of the 3D object within the scene; movement sensors (60) for detecting the user head position and distance from the display unit (20); tracking sensors (10) for detecting the user pupils position and pupillary distance; an interface (30) for the user interaction on the scene; processing means (42,44) for analysing the user response based on the data coming from sensors (60,10) and the interface (30), with the characteristics variations of the 3D object; and based on the estimation of a plurality of clinical parameters of the visual function related to binocularity, accommodation, ocular motility and visual perception.
    Type: Grant
    Filed: October 27, 2017
    Date of Patent: January 24, 2023
    Assignee: E-HEALTH TECHNICAL SOLUTIONS, S.L.
    Inventor: Eva Garćia Ramos
  • Patent number: 11557020
    Abstract: An eye tracking system for tracking one or more of a user's eyes includes an closed-eye detector operable to detect when a user has closed one or more of their eyes, an eye tracker operable to detect an eye orientation in dependence upon a measured deformation of an eyelid corresponding to the an eye that has been detected to be shut, and an image renderer operable to render a foveated image for display in response to the detected eye orientation.
    Type: Grant
    Filed: February 11, 2019
    Date of Patent: January 17, 2023
    Assignee: Sony Interactive Entertainment Inc.
    Inventor: Patrick John Connor
  • Patent number: 11547293
    Abstract: A method of processing a sequence of images of a retina acquired by an ophthalmic device to generate retinal position tracking information indicative of retina movement during acquisition. The method includes (i) receiving one or more images of the retina; (ii) calculating a cross-correlation between a reference image and an image based on the received image(s) to acquire an offset between the image and reference image; and repeating processes (i) and (ii) to acquire, as the tracking information, respective offsets for images that are based on the respective received image(s). Another step includes modifying the reference image during the repeating, by determining a measure of similarity between correspondingly located regions of pixels in two or more received images and accentuating features in the reference image representing structures of the imaged retina in relation to other features in the reference image based on the determined measure of similarity.
    Type: Grant
    Filed: August 14, 2017
    Date of Patent: January 10, 2023
    Assignee: OPTOS PLC
    Inventor: David Clifton
  • Patent number: 11523735
    Abstract: A headrest for an ophthalmic instrument facilitates fine positioning of the instrument relative to an eye of a test subject without the need to remove a contact element of the headrest from contact with the test subject's face. The ophthalmic instrument may be, for example, a rebound tonometer or a non-contact tonometer. The headrest includes a hollow bulbous contact element formed of resiliently deformable material, for example a thermoplastic elastomer (TPE) or silicone rubber. An outer surface of the contact element may have a spherical shape or a spheroidal shape when the contact element is not deformed.
    Type: Grant
    Filed: June 9, 2020
    Date of Patent: December 13, 2022
    Assignee: Reichert, Inc.
    Inventors: Russell J. Bonaventura, James M. Schweitzer
  • Patent number: 11518408
    Abstract: A driver monitor system and method for predicting impairment of a user of a vehicle. The system includes video cameras, an input device for inputting a list of medications being taken by the driver. Processing circuitry predicts side effects of the medications based on the half-life of the medication, detecting eye gaze movement, eye lid position, and facial expression of the user using images from the video camera, predicting whether the user is transitioning into an impaired physical state that is a side effect of the medications, verifying the side effect of the medications, determining whether the user is fit to drive using the verified side effects of the medications, and outputting to the vehicle an instruction to operate the vehicle in a level of automation that makes up for the at least one side effect or to perform a safe pull over operation of the vehicle.
    Type: Grant
    Filed: November 13, 2020
    Date of Patent: December 6, 2022
    Assignee: TOYOTA RESEARCH INSTITUTE, INC.
    Inventors: Nikos Arechiga-Gonzalez, Soonho Kong, Jonathan Decastro, Frank Permenter, Dennis Park
  • Patent number: 11510567
    Abstract: In accordance with one aspect of the present invention, an optical coherence tomography-based ophthalmic testing center system includes an optical coherence tomography instrument comprising an eyepiece for receiving at least one eye of a user or subject; a light source that outputs light that is directed through the eyepiece into the user's or subject's eye, an interferometer configured to produce optical interference using light reflected from the user's/subject's eye, an optical detector disposed so as to detect said optical interference; and a processing unit coupled to the detector. The ophthalmic testing center system can be configured to perform a multitude of self-administered functional and/or structural ophthalmic tests and output the test data.
    Type: Grant
    Filed: September 14, 2021
    Date of Patent: November 29, 2022
    Assignee: Doheny Eye Institute
    Inventors: Alexander C. Walsh, Paul G. Updike, Srinivas R. Sadda
  • Patent number: 11510568
    Abstract: A fundus imaging apparatus includes an imaging optical system that irradiates a fundus of a subject eye with light through an objective lens system, and enables to capture a fundus image of the subject eye based on return light from the subject eye, and a diopter correction unit that includes an optical element disposed on an optical path of the imaging optical system and a drive unit driving the optical element, and performs a diopter correction with a diopter value corresponding to a drive amount of the optical element. A drive range of the optical element in the diopter correction unit is set to avoid a specific range being a range in which an artifact caused by reflection light in the objective lens system is maximized.
    Type: Grant
    Filed: February 3, 2020
    Date of Patent: November 29, 2022
    Assignee: NIDEK CO., LTD.
    Inventors: Shinya Iwata, Megumi Tsuchiya, Yukihiro Higuchi
  • Patent number: 11503996
    Abstract: The object of the present invention is to develop an ophthalmologic microscope of a new method that increases the degree of freedom in the optical design in the Galilean ophthalmologic microscope provided with an OCT optical system. The present invention provides an ophthalmologic microscope 1 comprising; an illuminating optical system 300, an observation optical system 400; an objective lens 2; and an OCT optical system 500, characterized in that the optical axis O-500 of the OCT optical system does not penetrate through the objective lens 2, it comprises objective lens for OCT 507 through which the optical axis O-500 of the OCT optical system penetrates, and deflection optical elements 503a, 503b for scanning of the OCT optical system and the objective lens for OCT 507 are in a substantially optically conjugate positional relation.
    Type: Grant
    Filed: May 2, 2018
    Date of Patent: November 22, 2022
    Assignee: Topcon Corporation
    Inventors: Yasufumi Fukuma, Kazuhiro Oomori
  • Patent number: 11490805
    Abstract: A new technique is provided to easily grasp the form of the fundus and the like of the eye to be examined being depicted in a tomographic image. An ophthalmic information processing device includes an image rotation circuit and a display control circuit. The image rotation circuit rotates a tomographic image of the eye to be examined acquired by using optical coherence tomography while making a measurement optical axis be eccentric relative to a predetermined site of the eye to be examined, in accordance with an eccentric amount and an eccentric direction of the measurement optical axis relative to the predetermined site. The display control circuit causes a display device to display the tomographic image rotated by the image rotation circuit.
    Type: Grant
    Filed: January 31, 2020
    Date of Patent: November 8, 2022
    Assignee: TOPCON CORPORATION
    Inventors: Ryoichi Hirose, Tatsuo Yamaguchi
  • Patent number: 11471049
    Abstract: An ophthalmologic apparatus comprises eye information obtaining portions, each of the eye information obtaining portions corresponding to each of subject eyes of a subject and configured to obtain information on each of the subject eyes; imaging portions, each of the imaging portions corresponding to each of the eye information obtaining portions and configured to capture a subject eye image of each of the subject eyes; a reference calculator configured to obtain a three-dimensional reference position in each of the subject eye images captured by each of the imaging portions; an inclination calculator configured to obtain inclination information indicating inclination of relative positions of the subject eyes from the obtained three-dimensional reference positions in the subject eye images; and a notification portion configured to notify the obtained inclination information.
    Type: Grant
    Filed: January 27, 2020
    Date of Patent: October 18, 2022
    Assignee: TOPCON CORPORATION
    Inventors: Takafumi Yukimori, Shigeru Okikawa
  • Patent number: 11464407
    Abstract: A method for generating an indicator or biomarker of colour perception in a mammalian subject, where the method may include submitting the mammalian subject to a multicoloured dynamic stimulus comprising displaying, on a display device. The method may include controlling a change over time of at least one of the two colours of the multicolour pattern when displaying the dynamic multicolour stimulus, to vary the displayed luminance of this colour (usually several times). The method may include acquiring, by using an image acquisition device, an oscillatory response of a pupil of the mammalian subject. The method may include generating, from the acquired response, a signal representative of the power of the pupil's oscillatory response as a function of the change over time of at least one of the two colours when displaying the dynamic multicoloured stimulus.
    Type: Grant
    Filed: March 29, 2018
    Date of Patent: October 11, 2022
    Assignees: INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE (ICM), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CRNS), INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS (AP-HP), SORBONNE UNIVERSITE
    Inventors: Pierre Pouget, Alexis Genin
  • Patent number: 11452442
    Abstract: Disclosed are systems and methods for generating wide-field optical coherence tomography angiography (OCTA) images. In embodiments, multiple OCTA scans of a sample are automatically acquired at overlapping locations. The systems and methods include functionality to adaptively control the scanning procedure such that eye blink and eye motion events are detected in real time and accounted for during 3D scan acquisition. Also disclosed are methods for detecting and correcting motion-related artifacts in OCTA datasets which allow for the longer scan times over larger fields of view required for wide-field imaging. These methods may include division of en face angiogram images into a set of motion-free parallel strips, and application of gross and fine registration methods to align overlapping strips into a motion-corrected composite image. A series of overlapping motion-corrected composite images may be combined into a larger montage to enable wide-field OCTA imaging using multiple OCTA scans.
    Type: Grant
    Filed: June 15, 2017
    Date of Patent: September 27, 2022
    Assignee: OREGON HEALTH & SCIENCE UNIVERSITY
    Inventors: David Huang, Gangjun Liu, Yali Jia
  • Patent number: 11421979
    Abstract: The invention relates to a method for creating a two-dimensional interferogram with a Michelson-type free-beam interferometer, comprising an extended, partially spatially coherent light source and a two-dimensional light detector, wherein light from the light source is split by a beam splitter with a semitransparent beam splitter mirror into a sample light beam and a reference light beam and taken to a sample arm and a reference arm, wherein the sample light beam returning from a sample is directed by the beam splitter mirror onto the light detector, wherein the reference light beam emerging from the reference arm makes a predetermined angle greater than zero with the sample light beam on the light detector, and wherein the length of the reference arm is variable, where the reference light beam is directed by means of an odd number of reflections in each reflection plane in at least one reference arm section so that it is displaced laterally to itself and travels antiparallel through a light-deflecting elemen
    Type: Grant
    Filed: January 25, 2019
    Date of Patent: August 23, 2022
    Assignee: VISOTEC GMBH
    Inventors: Michael Münst, Helge Sudkamp, Peter Koch, Gereon Hüttmann
  • Patent number: 11422094
    Abstract: The analysis of data from fluorescence microscopy is disclosed, more especially fluorescence fluctuation microscopy, being a correlation analysis of fluctuation of the fluorescence intensity enabling quantitative and dynamic information capture. In particular the analysis is described of characteristics such as concentrations, mobility, interactions, stoichiometry, etc. of mixtures of particular that are fluorescently labeled with differently colored fluorophores having different excitation/emission spectra using fluctuation microscopy.
    Type: Grant
    Filed: January 11, 2019
    Date of Patent: August 23, 2022
    Assignees: Universiteit Hasselt, Ludwig-Maximilians-Universität München
    Inventors: Jelle Hendrix, Nick Smisdom, Don Lamb, Waldemar Schrimpf
  • Patent number: 11412926
    Abstract: A mobile communication device-based corneal topography system includes an illumination system, a mobile communication device and a corneal topography optical housing. The illumination system is configured to generate an illumination pattern and to generate reflections of the illumination pattern off a cornea of a subject, wherein the illumination system is aligned along an axis of centers of the illumination pattern. The mobile communication device includes an image sensor to capture an image of the reflected illumination pattern. The corneal topography optical housing is coupled to the illumination system and the mobile communication device, wherein the corneal topography optical housing supports and aligns the illumination system with the image sensor of the mobile communication device. The corneal topography optical housing includes an imaging system coupled to the image sensor.
    Type: Grant
    Filed: February 22, 2019
    Date of Patent: August 16, 2022
    Assignee: Intelligent Diagnostics, LLC
    Inventors: David A. Wallace, Stephen Klyce, John R Rogers, R Stephen Mulder, Mark A Kahan, Paul E Glenn
  • Patent number: 11406262
    Abstract: A device, system, and method for operating a nystagmus testing device is disclosed. The device comprising a camera configured to face a test subject to capture eye movements of the test subject, a start button configured to start a nystagmus routine, a front display positioned to face the test subject configured to display a visual stimulus, a rear display positioned to face a test administrator configured to display a visual tracker, and a controller configured to control movements of the visual stimulus and the visual tracker on the front and rear display, respectively, and generate data of the nystagmus routine.
    Type: Grant
    Filed: April 15, 2019
    Date of Patent: August 9, 2022
    Inventor: Peter F. Zahrt
  • Patent number: 11393251
    Abstract: A method for detecting one or more gaze-related parameters of a user is disclosed. In one example, the method includes creating a left image of at least a portion of a left eye of the user using a first camera of a head-wearable device worn by the user, and creating a right image of at least a portion of a right eye of the user using a second camera of the head-wearable device. The left and right images are fed together as an input into a convolutional neural network. One or more gaze-related parameters are obtained from the convolutional neural network as a result of the left and right images input.
    Type: Grant
    Filed: February 9, 2018
    Date of Patent: July 19, 2022
    Assignee: Pupil Labs GmbH
    Inventors: Marc Tonsen, Kai Dierkes, Moritz Kassner, Bernhard Petersch
  • Patent number: 11394896
    Abstract: Provided is a method for obtaining an image includes: obtaining first image data by photographing a first color by means of the image sensor while an IR illumination is turned on; obtaining second image data by photographing the first color by means of the image sensor while an IR illumination is turned off; extracting, from the first image data, first row data obtained from a first pixel of the image sensor; extracting, from the first image data, IR row data corresponding to an IR component of the first pixel; and generating correction data of the first pixel based on a difference between the first row data and the IR row data. According to an embodiment, the artificial intelligence (AI) module may be related to unmanned aerial vehicles (UAVs), robots, augmented reality (AR) devices, virtual reality (VR) devices, and 5G service-related devices.
    Type: Grant
    Filed: May 7, 2020
    Date of Patent: July 19, 2022
    Assignee: LG ELECTRONICS INC.
    Inventors: Jaehyun An, Jiwon Lee
  • Patent number: 11382503
    Abstract: The present invention is an OCT imaging system user interface for efficiently providing relevant image displays to the user. These displays are used during image acquisition to align patients and verify acquisition image quality. During image analysis, these displays indicate positional relationships between displayed data images, automatically display suspicious analysis, automatically display diagnostic data, simultaneously display similar data from multiple visits, improve access to archived data, and provide other improvements for efficient data presentation of relevant information.
    Type: Grant
    Filed: December 14, 2020
    Date of Patent: July 12, 2022
    Assignee: CARL ZEISS MEDITEC, INC.
    Inventors: Jochen Straub, Shahram Shawn Dastmalchi
  • Patent number: 11375892
    Abstract: An exemplary aspect is a method of processing data acquired by applying an optical coherence tomography (OCT) scan to a sample. The method includes preparing a three dimensional data set acquired from a sample, creating a two dimensional map based on representative intensity values of a plurality of pieces of A-scan data included in the three dimensional data set, placing the three dimensional data set based on the two dimensional map, and executing a process based on at least a partial data set of the three dimensional data set on which placement based on the two dimensional map has been performed.
    Type: Grant
    Filed: June 30, 2020
    Date of Patent: July 5, 2022
    Assignee: TOPCON CORPORATION
    Inventors: Hisashi Tsukada, Atsushi Kubota, Yasufumi Fukuma
  • Patent number: 11363947
    Abstract: An optical coherence tomographic device configured to acquire a tomographic image of a subjected eye is disclosed herein. The optical coherence tomographic device may include a light source of wavelength sweeping type; and a measurement optical system configured to irradiate the subjected eye with light outputted from the light source, where D/S×?>1.61 may be satisfied, with a diameter of the light outputted from the light source at an incident position to the subjected eye is D, a wavelength swept frequency of the light source is S, and a center wavelength of the light outputted from the light source is ?.
    Type: Grant
    Filed: January 20, 2021
    Date of Patent: June 21, 2022
    Assignee: TOMEY CORPORATION
    Inventors: Yuji Nozawa, Chihiro Kato, Takashi Kamo
  • Patent number: 11350820
    Abstract: The technology described in this document can be embodied in systems and computer-implemented methods for determining a score representing an amount of staining of the cornea. The methods include obtaining a digital image of the cornea stained with a tracer material, receiving a selection of a portion of the image, and processing, by a processing device, the selection to exclude areas with one or more artifacts to define an evaluation area. For each of a plurality of pixels within the evaluation area, a plurality of Cartesian color components are determined and a hue value in a polar coordinate based color space is calculated from the components. An amount of staining of the cornea is then determined as a function of the hue value. The methods also include assigning a score to the evaluation area based on the amount of staining calculated for the plurality of pixels.
    Type: Grant
    Filed: December 2, 2019
    Date of Patent: June 7, 2022
    Assignee: Massachusetts Eye and Ear Infirmary
    Inventors: Reza Dana, Francisco L. Amparo Pulido, Haobing Wang