Including Eye Photography Patents (Class 351/206)
  • Patent number: 11324398
    Abstract: A method is provided for observing structure and function of individual cells in a living human eye, comprising: using an adaptive optics optical coherence tomography (AO-OCT) system to image a volume of a retinal patch including numerous cells of different types, as for example, ganglion cells; using 3D subcellular image registration to correct for eye motion, including digitally dissecting the imaged volume; and using organelle motility inside the cell to increase cell contrast and to measure cell temporal dynamics.
    Type: Grant
    Filed: July 25, 2019
    Date of Patent: May 10, 2022
    Assignee: Indiana University Research and Technology Corporation
    Inventors: Donald Thomas Miller, Zhuolin Liu, Kazuhiro Suzuki, Furu Zhang
  • Patent number: 11307330
    Abstract: A variable focal length optical system includes: an imaging lens configured to condense a parallel beam of light from an objective lens to form an intermediate image; a relay system including, in sequence from an object side, a first relay lens and a second relay lens and configured to relay the intermediate image to infinity; and a lens system of a liquid resonant type which is located between the first relay lens and the second relay lens. A front principal point of the lens system is located to be conjugated with an exit pupil of the objective lens and an expression, 1.90?fTube/fR1?2.15, is satisfied. In the expression, fTube denotes a focal length of the imaging lens and fR1 denote a focal length of the first relay lens.
    Type: Grant
    Filed: January 14, 2021
    Date of Patent: April 19, 2022
    Assignee: MITUTOYO CORPORATION
    Inventors: Koji Kubo, Yuko Shishido
  • Patent number: 11298019
    Abstract: An ophthalmologic apparatus includes an acquisition unit and a controller. The acquisition unit includes an optical scanner capable of deflecting light in a predetermined deflection angle range. The acquisition unit is configured to acquire data of a subject's eye by performing A-scan on the subject's eye using optical coherence tomography by measurement light deflected by the optical scanner. The controller is configured to cause the acquisition unit to perform A-scan based on a deflection operation state of the optical scanner.
    Type: Grant
    Filed: December 18, 2019
    Date of Patent: April 12, 2022
    Assignee: TOPCON CORPORATION
    Inventors: Ryoichi Hirose, Tatsuo Yamaguchi
  • Patent number: 11294174
    Abstract: The present application provides a virtual image display apparatus. The virtual image display apparatus includes an image source configured to produce imaging illumination; an optical relay configured to receive the imaging illumination from the image source, and configured to transmit a detection light having an aberrated wavefront representing imaging distortion in a virtual image displayed by the virtual image display apparatus; a wavefront sensor configured to receive the detection light, and configured to detect wavefront aberration information from the detection light; and a wavefront correction processor configured to receive the wavefront aberration information from the wavefront sensor, and configured to adjust in real time the imaging illumination produced by the image source to reduce the imaging distortion in real time.
    Type: Grant
    Filed: June 8, 2018
    Date of Patent: April 5, 2022
    Assignee: BOE Technology Group Co., Ltd.
    Inventor: Yanjun Chen
  • Patent number: 11291363
    Abstract: An automatic strabismus detection mechanism includes a housing and an eyepiece arranged on the housing. A lens mechanism located on a same axis as the eyepiece is arranged in the housing. The lens mechanism is provided with a rotating mechanism for adjusting an angle of refraction. The automatic strabismus detection mechanism includes technical effects of being composed of the lens mechanism and automatically controlled to generate 0 to 50 prism degrees; the volume is small and the weight is light, which is lighter than that of a triangular prism block made of ordinary glass; and the manufacturing cost is low, which is about one fifth of the price of a lens row. Therefore, with the automatic strabismus detection mechanism, a variety of equipment and instruments based on the principle of triangular prism spectroscopic detection or dispersion is greatly improved, and development of related instruments and equipment is facilitated.
    Type: Grant
    Filed: November 29, 2018
    Date of Patent: April 5, 2022
    Inventor: Dongguang Liu
  • Patent number: 11295128
    Abstract: An example embodiment includes: a determination unit that, based on an image including an eye of a recognition subject, determines whether or not a colored contact lens is worn; and a matching unit that, when it is determined by the determination unit that the colored contact lens is worn, performs matching of the iris by using a feature amount extracted from a region excluding a predetermined range including an outer circumference of the iris out of a region of the iris included in the image.
    Type: Grant
    Filed: August 30, 2018
    Date of Patent: April 5, 2022
    Assignee: NEC CORPORATION
    Inventors: Mamoru Inoue, Jinit Bhatt
  • Patent number: 11283975
    Abstract: An imaging device includes a housing having a surface that can engage the face of a patient. A cavity is at least partially defined by the surface. An anterior imaging system includes an optical lens barrel positioned inside the cavity, and the optical lens barrel includes a variable focus lens at one end and an image sensor array at an opposite end. One or more illumination LEDs are positioned around the periphery of the optical lens barrel at opposite sides of the variable focus lens, and are configured to illuminate the cavity to capture images of an anterior of the eye.
    Type: Grant
    Filed: December 21, 2018
    Date of Patent: March 22, 2022
    Assignee: Welch Allyn, Inc.
    Inventors: Thomas A. Myers, Christian H. Reinke, Carlos A. Suarez, Ynjiun P. Wang
  • Patent number: 11262184
    Abstract: An optical coherence tomography (OCT) system for profilometry measurements of a specimen with a lateral resolution across the profilometry measurements is provided. The OCT system includes a line-field generator, an interferometer, and a spectrometer. The line-field generator includes a filter arranged in a focal plane of a lens for spatially filtering extended line-field light into a line-field light of a width equal to the lateral resolution. The interferometer is configured to interfere the line-field light reflected from the specimen illuminated with a line-shaped focus with a reference signal of the line-field light to produce an interference pattern. The spectrometer configured to analyze spectral components of the interference pattern in a digital domain to produce the profilometry measurements of the specimen.
    Type: Grant
    Filed: October 28, 2020
    Date of Patent: March 1, 2022
    Assignee: Mitsubishi Electric Research Laboratories, Inc.
    Inventors: David Millar, Celalettin Yurdakul, Pu Wang, Kieran Parsons
  • Patent number: 11259700
    Abstract: Ocular surface interferometry devices, systems, and methods are disclosed for imaging an ocular tear film. An imaging device can be focused on the lipid layer of the tear film to capture optical wave interference interactions of specularly reflected light from the tear film combined with a background signal(s) in a first image, wherein the specularly reflected light may be produced from various portions of the ocular tear film by obliquely illuminating various portions of the ocular tear film with a multi-wavelength light source, such as in a tiling pattern(s). The imaging device can also be focused on the lipid layer to capture a second image containing the background signal(s) present in the first image. The second image can be subtracted from the first image to reduce and/or eliminate the background signal(s) in the first image to produce a resulting image, which can used to measure a tear film layer thickness.
    Type: Grant
    Filed: February 5, 2020
    Date of Patent: March 1, 2022
    Assignee: TearScience Inc
    Inventors: Donald R. Korb, William L. Weber, Randal B. Chinnock, Benjamin T. Gravely, Stephen M. Grenon
  • Patent number: 11253198
    Abstract: The present invention is a Miniature Vein Enhancer that includes a Miniature Projection Head. The Miniature Projection Head may be operated in one of three modes, AFM, DBM and RTM. The Miniature Projection Head of the present invention projects an image of the veins of a patient which aids the practitioner in pinpointing a vein for an intravenous drip, blood test, and the like. The Miniature projection head may have a cavity for a power source or it may have a power source located in a body portion of the Miniature Vein Enhancer. The Miniature Vein Enhancer may be attached to one of several improved needle protectors, or the Miniature Vein Enhancer may be attached to a body similar to a flashlight for hand held use. The Miniature Vein Enhancer of the present invention may also be attached to a magnifying glass, a flat panel display, and the like.
    Type: Grant
    Filed: November 16, 2017
    Date of Patent: February 22, 2022
    Assignee: AccuVein, Inc.
    Inventors: Fred Wood, Ron Goldman, Stephen P. Conlon, Vincent Luciano
  • Patent number: 11253151
    Abstract: A multispectral or hyperspectral ocular surface evaluating device is disclosed, comprising an illumination projector, which comprises a broadband illumination source panel and a polarizing structure to illuminate an ocular surface and adjacent structures of an eye and project a pattern on the ocular surface; an imaging system to form images; a detection system to record the images with a plurality of spectral channels in visible and near infrared spectra; and a computer to display and analyze the images. Also disclosed is a method of evaluating ocular surface health using a multispectral or hyperspectral ocular surface evaluating device, which comprises illuminating an ocular surface and adjacent structures of an eye with polarized light from an illumination projector; forming images with the imaging system; recording images formed on the detection system; digitally processing the recorded images; and analyzing the recorded images to evaluate ocular surface health with the computer.
    Type: Grant
    Filed: September 8, 2019
    Date of Patent: February 22, 2022
    Inventor: Aizhong Zhang
  • Patent number: 11246481
    Abstract: The present disclosure provides systems and methods for characterizing thin films, such as, for example, diagnosis of dry eye syndrome, thin-film optical metrology testing, etc. The present disclosure may be embodied as a tearscope, which is sometimes referred to herein as a Macroscopic Imaging Ellipsometer (MIE) because it may be considered to be an imaging ellipsometer with, for example, a field-of-view on the order of tens of millimeters or more (i.e., macroscopic), compared with conventional imaging ellipsometers, which usually employ microscope objectives and have fields-of-view of up to several hundred microns.
    Type: Grant
    Filed: May 29, 2019
    Date of Patent: February 15, 2022
    Assignee: University of Rochester
    Inventors: James M. Zavislan, Aizhong Zhang
  • Patent number: 11238279
    Abstract: According to various embodiments, an electronic device may include a first light emitter comprising first light emitting circuitry configured to output light of a first wave bandwidth, a second light emitter comprising second light emitting circuitry configured to output light of a second wave bandwidth, a camera including an image sensor configured to arrange one or more first pixels for sensing the light corresponding to the first wave bandwidth and the second wave bandwidth and one or more second pixels for sensing the light corresponding to the second wave bandwidth, and a processor. The processor may be configured to control the electronic device to output the first wave bandwidth light using a first light source and the second wave bandwidth light using a second light source, and a control circuit electrically coupled to the image sensor and connected to an application processor through a designated interface.
    Type: Grant
    Filed: March 1, 2019
    Date of Patent: February 1, 2022
    Assignee: Samsung Electronics Co., Ltd.
    Inventors: Woontahk Sung, Hwayong Kang, Jongsun Kim, Kihuk Lee, Bongchan Kim
  • Patent number: 11224342
    Abstract: The invention relates to a device and a method for examining the retinal vascular endothelial function of the vessels of the retina at the fundus (F) of a patient's eye. Using a fundus camera, the vessels of the retina are stimulated with flicker light during a stimulation phase and sequences of images of areas of the fundus (F) are recorded, from which vascular parameters are derived which describe the retinal vascular endothelial function of the vessels. By imaging a macula stop (MB), which covers the macula, onto the fundus (F), the fundus (F) can be illuminated with a higher light intensity, which improves the stimulation effect and the image quality and/or reduces the strain on the patient.
    Type: Grant
    Filed: July 26, 2018
    Date of Patent: January 18, 2022
    Assignee: IMEDOS SYSTEMS GMBH
    Inventors: Walthard Vilser, Jens Haueisen, Sascha Klee, Dietmar Link, Thomas Riemer, Martin Skorsetz
  • Patent number: 11222187
    Abstract: A scanner is provided having an integrated or retrofitted amber filter placed in front of white illumination LEDs. When an object/item is placed within a field of view of a lens of the scanner, the white illumination LEDs are illuminated and pass through the amber filter, which filters out light in the light spectrum of approximately 340-500 nm. The object/item is illuminated with light approximately above 500 nm and reflected back through a portion of the lens that covers an imaging sensor resulting in an object/item image in the light spectrum approximately above 500 nm, which improves the user experience by removing the glaring blue light component of the white LEDs illumination while not impacting the performance of the object/item recognition when processed for a transaction being conducted at a transaction terminal that is interfaced to the scanner.
    Type: Grant
    Filed: June 29, 2020
    Date of Patent: January 11, 2022
    Assignee: NCR Corporation
    Inventor: Frank Shearer
  • Patent number: 11219366
    Abstract: According to an embodiment of the present disclosure, there is provided a retina photographing apparatus including: a body unit including a case providing an outer appearance of the retina photographing apparatus, and a holder connected to the case and being mountable on an examinee's head; a retina photographing unit installed inside the case, and configured to irradiate light onto a retina of the examinee's left or right eye and to detect the light reflected from the retina to acquire an image of the retina; and a driving unit configured to move a position of the retina photographing unit inside the case in order to photograph both of the examinee's eyes.
    Type: Grant
    Filed: January 30, 2018
    Date of Patent: January 11, 2022
    Assignee: ROOTEEHEALTH, INC.
    Inventors: Kyung Min Kook, Su Ryeon Kim
  • Patent number: 11219365
    Abstract: The present subject matter relates to an ophthalmologic imaging apparatus, which can capture reflex-free retinal images of a subject's eye. The imaging apparatus comprises light sources arranged on an illumination axis. A first shield placed at a distance from a first condenser lens, which is placed in front of a photographic light source on the illumination axis. The first shield has a central opaque portion on which an observation light source is mounted, and an outer pair of coaxial annular transparent regions. A diffuser is placed in front of the observation light source. A second shield has a central opening portion and mounted on the diffuser. The imaging apparatus further comprises a porosity mirror mounted on a porosity tube.
    Type: Grant
    Filed: September 4, 2017
    Date of Patent: January 11, 2022
    Assignee: REMIDIO INNOVATIVE SOLUTIONS PVT. LTD.
    Inventors: Shanmuganathan Nagarajan, Anand Sivaraman
  • Patent number: 11213202
    Abstract: An ophthalmologic apparatus includes an SLO system, a projection system, a first image former, a second image former, a displacement processor, and a controller. The SLO system is configured to scan a target eye with first light deflected by an first optical scanner. The projection system is configured to project second light deflected by an second optical scanner onto the target eye. The first image former is configured to form a first image of the target eye based on a scan result of a first scan region using the first optical scanner. The second image former is configured to form a second image of the target eye based on a scan result of a second scan region using the first optical scanner, the second scan region being narrower than the first scan region. The displacement processor is configured to calculate a displacement between a partial image in the first image and the second image, the partial image corresponding to the second image.
    Type: Grant
    Filed: September 26, 2019
    Date of Patent: January 4, 2022
    Assignee: TOPCON CORPORATION
    Inventors: Masahiro Shibutani, Tatsuo Yamaguchi, Toshihiro Mino, Ryoichi Hirose
  • Patent number: 11213208
    Abstract: A multispectral imaging device in accordance with one embodiment comprises: an illumination unit for emitting LED lighting to the skin for skin illumination; and a detection unit for causing light reflected from the skin to be incident on a camera, wherein the illumination unit is arranged on the outer side of the detection unit, so that a path of the LED lighting emitted from the illumination unit is formed on the outer side of the detection unit, and a path of the light reflected from the skin is formed on the inner side of the detection unit.
    Type: Grant
    Filed: March 7, 2017
    Date of Patent: January 4, 2022
    Assignee: DAEGU GYEONGBUK INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Jae Youn Hwang, Jae Eun Jang, Man Jae Kim
  • Patent number: 11206978
    Abstract: Meta-lens based ocular imaging, near-eye display, and eye-tracking systems are described. The systems can include a single focusing optic and an integrated circuit that provides illumination light and includes an imaging array. The focusing optic includes meta-atoms formed on a substrate. The systems may have no moving parts and achieve imaging or image-projection fields-of-view approaching or exceeding 180 degrees. Because of their low part count, the systems can be robust and have a very small form factor.
    Type: Grant
    Filed: February 1, 2021
    Date of Patent: December 28, 2021
    Assignee: Massachusetts Institute of Technology
    Inventors: Juejun Hu, Tian Gu, Mikhail Shalaginov, Fan Yang
  • Patent number: 11191429
    Abstract: A device to determine a state of the lacrimal layer of the eye includes at least one light source arranged to form a pattern of source points for projecting a plurality of light rays onto a cornea surface; a lens-camera system arranged to receive a respective plurality of reflected light rays reflected on the cornea surface, thereby forming a pattern of image points; and a computational unit arranged to determine on the basis of the image points the state of the lacrimal layer of the eye and/or to determine on the basis of the image points data representative for the state of the lacrimal layer of the eye and to provide the data representative for the state of the lacrimal layer of the eye to a user.
    Type: Grant
    Filed: February 23, 2018
    Date of Patent: December 7, 2021
    Assignee: Cassini Technologies B.V.
    Inventors: Maarten Pieter Huijbregtse, Haaije Rimmer De Vries
  • Patent number: 11185221
    Abstract: An ophthalmologic apparatus includes an OCT measurement unit, a corneal shape measurement unit, an eyeball model generator, and a site specifying unit. The OCT measurement unit is configured to acquire data of a subject's eye by deflecting measurement light using an optical scanner to project onto the subject's eye and detecting interference light between returning light of the measurement light from the subject's eye and reference light. The corneal shape measurement unit is configured to obtain curvature radius distribution on a cornea by detecting returning light of a measurement pattern projected onto a cornea of the subject's eye. The eyeball model generator is configured to generate an eyeball model using the curvature radius distribution on the cornea.
    Type: Grant
    Filed: August 14, 2019
    Date of Patent: November 30, 2021
    Assignee: TOPCON CORPORATION
    Inventors: Makoto Saika, Tsutomu Kikawa
  • Patent number: 11185222
    Abstract: A method for imaging vertebrate translucent retinal structures includes: imaging a translucent retinal structure at a first imaging plane in the retina with a light source focused at such first imaging plane, and detecting reflected light with a non-confocal off-axis detector, wherein the detector is axially displaced from a plane conjugate to the first imaging plane to a plane conjugate to a reflective layer deeper in the retina along a path of illumination from the light source.
    Type: Grant
    Filed: November 30, 2018
    Date of Patent: November 30, 2021
    Assignee: University of Rochester
    Inventors: Raul Andres Guevara-Torres, Jesse Schallek
  • Patent number: 11164313
    Abstract: The present invention relates to a method of assisting in diagnosis of a target heart disease using a retinal image, the method including: obtaining a target retinal image which is obtained by imaging a retina of a testee; on the basis of the target retinal image, obtaining heart disease diagnosis assistance information of the testee according to the target retinal image, via a heart disease diagnosis assistance neural network model which obtains diagnosis assistance information that is used for diagnosis of the target heart disease according to the retinal image; and outputting the heart disease diagnosis assistance information of the testee.
    Type: Grant
    Filed: March 3, 2020
    Date of Patent: November 2, 2021
    Assignee: MEDI WHALE INC.
    Inventors: Tae Geun Choi, Geun Yeong Lee, Hyung Taek Rim
  • Patent number: 11164322
    Abstract: Disclosed is an eyeball movement analysis system. The eyeball movement analysis system includes an image capturing unit configured to acquire a first image of an eyeball at a reference location and acquire a second image of the eyeball at a moved location, and an eyeball movement analyzing unit configured to calculate a rotational angle of the eyeball and a translational distance of the eyeball in a process of moving the eyeball from the reference location to the moved location through comparison of the first image and the second image.
    Type: Grant
    Filed: September 4, 2019
    Date of Patent: November 2, 2021
    Assignee: IUCF-HYU (INDUSTRY-UNIVERSITY COOPERATION FOUNDATION HANYANG UNIVERSITY)
    Inventors: Han Woong Lim, Won June Lee, Yumi Song
  • Patent number: 11160449
    Abstract: A method of imaging an interior of an eye includes illuminating the interior of the eye with one or more beams of light from a light source, and said illuminating is configured to trigger a change to a pupil of the eye. An image sensor captures a sequence of images of light reflected by the interior of the eye during an expected timeframe when a width of the pupil is changing in response to said illuminating. A processing apparatus combines images in the sequence of images to form a composite image having a larger depth of field than a depth of field of each of the images in the sequence of images. The depth of field for each of the images corresponds to the width of the pupil when each of the images is captured.
    Type: Grant
    Filed: July 26, 2018
    Date of Patent: November 2, 2021
    Assignee: Verily Life Sciences LLC
    Inventors: Dhruv Lamba, Sam Kavusi
  • Patent number: 11147489
    Abstract: Various embodiments provide systems and methods for identifying impairment using measurement devices.
    Type: Grant
    Filed: March 17, 2020
    Date of Patent: October 19, 2021
    Assignee: BI Incorporated
    Inventors: Duke Hanson, Jr., Dustin Pettit, Joseph P. Newell
  • Patent number: 11147446
    Abstract: An information processing apparatus including an acquisition unit configured to acquire a first three-dimensional optical coherence tomography (OCT) image of a target eye, and a display control unit configured to display, on a display unit, the first three-dimensional OCT image and an interface configured to receive an instruction for acquiring a second three-dimensional OCT image of the target eye, which is an image captured with a fixation target position the same as a fixation target position used in capturing the first three-dimensional OCT image and is to be combined with the first three-dimensional OCT image.
    Type: Grant
    Filed: August 31, 2018
    Date of Patent: October 19, 2021
    Assignee: Canon Kabushiki Kaisha
    Inventor: Hiroshi Imamura
  • Patent number: 11150469
    Abstract: In one implementation, a method includes emitting light with modulating intensity from a plurality of light sources towards an eye of a user. The method includes receiving light intensity data indicative of an intensity of the plurality of glints reflected by the eye of the user in the form of a plurality of glints and determining an eye tracking characteristic of the user based on the light intensity data. In one implementation, a method includes generating, using an event camera comprising a plurality of light sensors at a plurality of respective locations, a plurality of event messages, each of the plurality of event messages being generated in response to a particular light sensor detecting a change in intensity of light and indicating a particular location of the particular light sensor. The method includes determining an eye tracking characteristic of a user based on the plurality of event messages.
    Type: Grant
    Filed: September 27, 2018
    Date of Patent: October 19, 2021
    Inventors: Branko Petljanski, Raffi A. Bedikian, Daniel Kurz, Thomas Gebauer, Li Jia
  • Patent number: 11138305
    Abstract: Users can be authenticated based on pupil dilation response to a challenge prompt. In response to an authentication request, a registered challenge prompt and an expected pupil dilation response can be retrieved. The challenge prompt can include one or more images or a video designed to cause a pupil dilation response in a user. The challenge prompt is displayed to the user and the user's pupil dilation response is captured. The user's pupil dilation response is compared to the expected pupil dilation response. The user is authenticated based on the pupil dilation response and the expected pupil dilation response being substantially similar.
    Type: Grant
    Filed: May 28, 2020
    Date of Patent: October 5, 2021
    Assignee: WELLS FARGO BANK, N.A.
    Inventors: Noah L. Hughes, John Ervin Eisenhauer
  • Patent number: 11129529
    Abstract: An ophthalmologic apparatus includes a refractometry optical system, an OCT optical system, a fixation projection system, and a controller. The refractometry optical system is configured to project light onto a subject's eye and to detect returning light from the subject's eye. The OCT optical system is configured to split light from an OCT light source into measurement light and reference light, to project the measurement light onto the subject's eye, and to detect interference light between returning light of the measurement light from the subject's eye and the reference light. The fixation projection system is configured to simultaneously project a first fixation target and a second fixation target onto the subject's eye, a visual angle of the second fixation target being narrower than a visual angle of the first fixation target. The controller is configured to control the refractometry optical system and the OCT optical system to simultaneously perform a refractometry and an OCT measurement.
    Type: Grant
    Filed: June 6, 2019
    Date of Patent: September 28, 2021
    Assignee: TOPCON CORPORATION
    Inventor: Yoko Tatara
  • Patent number: 11131539
    Abstract: A system and method for acquiring imaging data of an object. The system includes a beam splitter for directing a derivative sample beam towards the object and a derivative reference beam towards a reflective element; a detector for detecting at least one of the returned reference beam and the returned sample beam; a mode switching module for selecting an operating mode between an optical coherence tomography (OCT) mode and a hyperspectral imaging (HSI) mode; and a computing module for receiving the detection from the detector and the mode from the mode switching module, wherein in the OCT mode, the computing device generates OCT imaging data by determining an interference pattern produced by a superposition of the returned reference beam and the returned sample beam, and wherein in the HSI mode, the computing module generating hyperspectral imaging data by determining hyperspectral information of the returned sample beam.
    Type: Grant
    Filed: June 12, 2018
    Date of Patent: September 28, 2021
    Assignee: SIGHTLINE INNOVATION INC.
    Inventors: Wallace Trenholm, Lorenzo Pons
  • Patent number: 11116394
    Abstract: Apparatus and methods are described for performing tear film structure measurement on a tear film of an eye of a subject. A broadband light source (100) is configured to generate broadband light. A spectrometer (250) is configured to measure a spectrum of light of the broadband light that is reflected from at least one spot on the tear film, the spot having a diameter of between 100 microns and 240 microns. A computer processor (28) is coupled to the spectrometer and configured to determine a characteristic of the tear film based upon the spectrum of light measured by the spectrometer. Other applications are also described.
    Type: Grant
    Filed: August 2, 2017
    Date of Patent: September 14, 2021
    Assignee: AdOM, ADVANCED OPTICAL TECHNOLOGIES LTD.
    Inventors: Yoel Arieli, Yoel Cohen, Shlomi Epstein, Dror Arbel, Ra'anan Gefen
  • Patent number: 11118894
    Abstract: In some embodiments, systems, methods, and media for multiple reference arm spectral domain optical coherence tomography are provided which, in some embodiments, includes: a sample arm coupled to a light source; a first reference arm having a first path length; a second reference arm having a longer second path length; a first optical coupler that combines light from the sample arm and the first reference arm; a second coupler that combines light from the sample arm and the second reference arm; and an optical switch comprising: a first input port coupled to the first optical coupler; a second input coupled to the second coupler via an optical waveguide that induces a delay at least equal to an acquisition time of an image sensor; and an output coupled to the image sensor.
    Type: Grant
    Filed: October 12, 2018
    Date of Patent: September 14, 2021
    Assignee: THE GENERAL HOSPITAL CORPORATION
    Inventors: Guillermo J. Tearney, Yogesh Verma, David Odeke Otuya, Romain Luu
  • Patent number: 11107214
    Abstract: A method and device for evaluating the dynamics of a tear fluid layer to objectively and accurately evaluate breakdown of the tear fluid layer, which is a core mechanism of dry eye, are provided. The method includes a step of acquiring color information of each pixel in a predetermined region of a tear fluid layer interference fringe image, which is a moving image or a plurality of static images, a step of calculating a numerical value indicating the diversity of color from the acquired color information, a step of calculating the average value of the color information, and a step of calculating a coefficient of variation on the basis of the calculated numerical value indicating the diversity of color and the calculated average value of the color information. The coefficient of variation is used as an index for evaluating the dynamics of the tear fluid layer.
    Type: Grant
    Filed: April 27, 2018
    Date of Patent: August 31, 2021
    Assignees: KYOTO PREFECTURAL PUBLIC UNIVERSITY CORPORATION, KOWA COMPANY, LTD.
    Inventors: Norihiko Yokoi, Katsumi Yabusaki
  • Patent number: 11108977
    Abstract: An eye is illuminated with a first non-visible light wavelength and a second non-visible light wavelength. A first ocular image is captured from first reflected light having the first non-visible light wavelength and a second ocular image is captured from second reflected light having the second non-visible light wavelength.
    Type: Grant
    Filed: February 20, 2020
    Date of Patent: August 31, 2021
    Assignee: Facebook Technologies, LLC
    Inventors: Robin Sharma, Andrew John Ouderkirk, Qi Zhang, Christopher Yuan-Ting Liao, Karol Constantine Hatzilias
  • Patent number: 11096826
    Abstract: An ophthalmological apparatus comprises a laser source for producing a pulsed laser beam, a scanner system for deflecting the pulsed laser beam at a treatment speed in the eye tissue along a scanning treatment line, a first scanning apparatus connected upstream of the scanner system for deflecting the pulsed laser beam and for producing a first scanning movement component superposed on the scanning treatment line in a first scanning direction at a first scanning speed that is higher as compared to the treatment speed, and a second scanning apparatus connected upstream of the scanner system for deflecting the pulsed laser beam and for producing a second scanning movement component, which is superposed on the first scanning movement component in a second scanning direction, which is at an angle to the first scanning direction, at a second scanning speed that is higher as compared to the first scanning speed.
    Type: Grant
    Filed: December 19, 2018
    Date of Patent: August 24, 2021
    Assignee: Ziemer Ophthalmic Systems AG
    Inventor: Christian Rathjen
  • Patent number: 11079491
    Abstract: Systems and methods are provided for provided for determining the presence of an object within a region of interest. A broadband laser is projected at a selected location in the region of interest. Reflected light from the selected location in the region of interest is received at a receiver. The received light is dispersed by wavelength across a first axis at a dispersive element. The received light is dispersed by return angle across a second axis at a defocuser. The received light is imaged to provide an image, and a metric representing a correlation between the wavelength and the return angle is measured in the image to determine the presence of the object.
    Type: Grant
    Filed: August 13, 2018
    Date of Patent: August 3, 2021
    Assignee: NORTHROP GRUMMAN SYSTEMS CORPORATION
    Inventor: Alan Heins
  • Patent number: 11080850
    Abstract: Disclosed herein are a glaucoma diagnosis method using a fundus image and an apparatus for the same. The glaucoma diagnosis method includes performing data amplification of generating multiple transformed images for an original fundus image based on a preprocessed image of the original fundus image, allowing multiple individual learning models of different types to be learned based on the multiple transformed images and generating a glaucoma determination model based on respective outputs of the learned multiple individual learning models, and diagnosing a class of glaucoma for the original fundus image based on the glaucoma determination model.
    Type: Grant
    Filed: January 11, 2019
    Date of Patent: August 3, 2021
    Assignees: ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTE, Konyang University Industry-Academic Cooperation Foundation
    Inventors: Hyeon-Sung Cho, Jae-Hoon Jeong, Jong-Yeup Kim, Ji-Sang Park
  • Patent number: 11064879
    Abstract: A method for holoscopic, optical coherence tomography for an object, wherein the method includes providing source radiation and splitting the source radiation into illumination radiation and reference radiation, illuminating an illumination field on the object with illumination radiation, said illumination field having an areal extent transverse to the direction of incidence, collecting illumination radiation scattered back from the object as measurement radiation, separating the measurement radiation collected from the object from the illumination radiation, and overlaying the measurement radiation with reference radiation and detecting an interference signal of the overlaid radiations with at least one areal detector with a two-dimensional extent, wherein the object in the illumination field is simultaneously illuminated by more than one spatial radiation mode, wherein the radiation modes of the illumination in the illumination field are spatially and temporally coherent with one another but have a fixed ph
    Type: Grant
    Filed: June 13, 2019
    Date of Patent: July 20, 2021
    Assignee: Carl Zeiss Meditec AG
    Inventor: Daniel Bublitz
  • Patent number: 11058293
    Abstract: An image processing apparatus includes an identification unit configured to identify periodicity of a fundus image obtained by capturing an image of a fundus of an eye, and an information acquisition unit configured to acquire information indicating an imaging state of photoreceptor cells in the fundus image based on the periodicity.
    Type: Grant
    Filed: February 27, 2019
    Date of Patent: July 13, 2021
    Assignee: Canon Kabushiki Kaisha
    Inventors: Keiko Yonezawa, Kazuhide Miyata
  • Patent number: 11058295
    Abstract: An ophthalmic measurement device and measurement system include a projection unit projecting an image on tear fluid accumulated at an edge of an eyelid and a surface of a cornea and conjunctiva; an imager takes a picture of the tear fluid accumulated at an edge of an eyelid and the surface of a cornea and conjunctiva; and a calculator determines a physical quantity of the tear fluid accumulated at an edge of an eyelid. The calculator acquires a physical quantity of a first reflection of the image projected on the tear fluid accumulated at an edge of an eyelid, and calculates a curvature radius of the surface of the tear fluid, from a distance between the projection unit and the surface of the tear fluid obtained by distance measurement, a physical quantity of the image, and the physical quantity of the first reflection.
    Type: Grant
    Filed: August 2, 2018
    Date of Patent: July 13, 2021
    Assignee: ELRISE CORPORATION
    Inventors: Yoshiro Okazaki, Mamoru Iwabuchi, Toshiyuki Ookubo, Tatsuki Takenaga, Taku Miyake, Norihiko Yokoi
  • Patent number: 11062801
    Abstract: Systems and methods are disclosed for processing an electronic image corresponding to a specimen. One method for processing the electronic image includes: receiving a target electronic image of a slide corresponding to a target specimen, the target specimen including a tissue sample from a patient, applying a machine learning system to the target electronic image to determine deficiencies associated with the target specimen, the machine learning system having been generated by processing a plurality of training images to predict stain deficiencies and/or predict a needed recut, the training images including images of human tissue and/or images that are algorithmically generated; and based on the deficiencies associated with the target specimen, determining to automatically order an additional slide to be prepared.
    Type: Grant
    Filed: December 30, 2020
    Date of Patent: July 13, 2021
    Assignee: PAIGE.AI, INC.
    Inventors: Rodrigo Ceballos Lentini, Christopher Kanan, Patricia Raciti, Leo Grady, Thomas Fuchs
  • Patent number: 11058296
    Abstract: A storage device of an ophthalmologic image display device of an embodiment stores a three dimensional data set acquired by scanning a subject's eye using OCT. An image processor forms, based on the three dimensional data set, a B-mode image, front images, and composite front image obtained from the front images. A display controller displays the B-mode image, front images and composite front image in a predetermined layout. The display controller displays distinguishment color information for distinguishment between the front images by colors and slice area information that indicates a partial region of the B-mode image corresponding to a slice area of the three dimensional data set represented by each front image in a color according to the distinguishment color information, and displays a composite front image based on the front images, each of which is expressed by a color according to the distinguishment color information.
    Type: Grant
    Filed: October 25, 2016
    Date of Patent: July 13, 2021
    Assignee: TOPCON CORPORATION
    Inventors: Taiki Aimi, Masahiro Akiba, Atsushi Kubota
  • Patent number: 11058298
    Abstract: Disclosed is a polarization fundus camera including: an illumination unit emitting light; a diffusion lens; an illumination lens irradiating the light introduced from the diffusion lens; a mirror reflecting light introduced from the illumination lens; a polarization beam splitter; an objective lens enlarging an image of a fundus formed by the light introduced from the polarization beam splitter; a short-range eyepiece lens reducing an image of the fundus enlarged by the objective lens; a linear polarization filter; a narrowband optical filter; and an imaging device.
    Type: Grant
    Filed: July 6, 2018
    Date of Patent: July 13, 2021
    Assignee: AIINSIGHT INC.
    Inventors: Han Jo Kwon, Keun Heung Park
  • Patent number: 11062444
    Abstract: The invention relates to an artificial intelligence cataract analysis system, including a pattern recognition module for recognizing a photo mode of an input eye image, wherein the photo mode is divided according to the slit width of the illuminating slit during photographing of the eye image and/or whether a mydriatic treatment is carried out; a preliminary analysis module used for selecting a corresponding deep learning model for eye different photo modes, analyzing the characteristics of lens in the eye image by using a deep learning model, and further performing classification in combination with cause and severity degree of a disease. The invention can perform cataract intelligent analysis on eye images with different photo modes by using deep learning models, so that the analysis accuracy is improved.
    Type: Grant
    Filed: August 8, 2019
    Date of Patent: July 13, 2021
    Assignee: ZHONGSHAN OPHTHALMIC CENTER OF SUN YAT-SEN UNIVERSITY
    Inventors: Haotian Lin, Xiaohang Wu, Weiyi Lai
  • Patent number: 11051690
    Abstract: An ophthalmological image processing apparatus includes an image obtaining portion for obtaining ophthalmological image data, which is captured by an imaging unit, of a subject eye, and an image processing portion for processing the ophthalmological image data. The image processing portion uses a first front image of the subject eye in a first depth region to correct a second front image of the subject eye captured in a second depth region which is different from the first depth region. The first front image and the second front image are constructed based on the ophthalmological image data. The ophthalmological image processing apparatus can reduce an artifact which is generated in an ophthalmological image.
    Type: Grant
    Filed: February 22, 2019
    Date of Patent: July 6, 2021
    Assignee: NIDEK CO., LTD.
    Inventors: Ryosuke Shiba, Tetsuya Kano, Naoki Takeno
  • Patent number: 11055846
    Abstract: The disclosure provides a method for obtaining a fluorescent fundus image, the method including the following steps: receiving a to-be-detected color fundus image; obtaining a color feature of the to-be-detected color fundus image; encoding the color feature of the to-be-detected color fundus image according to a fundus image transformation model to transform the to-be-detected color fundus image into a to-be-detected fluorescent fundus image; and outputting the to-be-detected fluorescent fundus image.
    Type: Grant
    Filed: May 14, 2019
    Date of Patent: July 6, 2021
    Assignees: Acer Incorporated, National Taiwan University
    Inventors: Ming-Ke Chen, Chin-Han Tsai, Yi-Ting Hsieh
  • Patent number: 11048101
    Abstract: A wearable ophthalmic device is disclosed. The device may include an outward facing head-mounted light field camera to receive light from a user's surroundings and to generate numerical light field image data. The device may also include a light field processor to generate modified numerical light field image data by computationally introducing an amount of optical power to the numerical light field image data based on a viewing distance from the user to an object. The device may also include a head-mounted light field display to generate a physical light field corresponding to the modified numerical light field image data.
    Type: Grant
    Filed: September 6, 2019
    Date of Patent: June 29, 2021
    Assignee: Magic Leap, Inc.
    Inventors: John Graham Macnamara, Nicole Elizabeth Samec, Nastasja U. Robaina, Eric Baerenrodt, Christopher M. Harrises
  • Patent number: RE49023
    Abstract: A fundus observation apparatus that is capable of assisting an examiner in judging the presence or absence of abnormality in an examinee's eye based on a fundus tomographic image. The fundus observation apparatus includes an optical coherence tomography device that has an optical scanner for setting an image pickup position on a fundus of an examinee's eye, and is arranged to obtain a tomographic image of the fundus, and an information display unit that is arranged to display on a monitor the tomographic image obtained by the optical coherence tomography device and assisting information for assisting an examiner in performing judgment on the tomographic image, and the information display unit is arranged to change the assisting information based on image pickup information on the tomographic image.
    Type: Grant
    Filed: April 8, 2015
    Date of Patent: April 12, 2022
    Assignee: NIDEK CO., LTD.
    Inventors: Naoki Isogai, Toshio Murata