For Size Of Particles Patents (Class 356/335)
  • Patent number: 11403747
    Abstract: A fine ratio measuring device that measures the fine ratio of fines adhering to the surface of the material in the form of lumps includes: an illumination unit that illuminates the material in the form of lumps; an imaging unit that captures an image of the material in the form of lumps and produces image data; and an arithmetic unit including a computation unit that computes a characteristic quantity of the image data produced by the imaging unit and a conversion unit that converts the characteristic quantity computed by the computation unit to the fine ratio.
    Type: Grant
    Filed: November 29, 2017
    Date of Patent: August 2, 2022
    Assignee: JFE Steel Corporation
    Inventors: Naoshi Yamahira, Takahiro Nishino, Takehide Hirata, Kazuro Tsuda, Toshiki Tsuboi
  • Patent number: 11403751
    Abstract: A method and system for classification of cells and particles in a biological sample using an automated image-based feature extraction and classification architecture. A method operates by applying a mask or series of masks to an image, extracting features from the unmasked portions of the image based on the content and location of colored pixels, selecting a subset of the extracted features, and mapping the subset of the extracted features into a classifier architecture. In a majority of cases, the first level model architecture provides an accurate identification of the cell or particle. In a minority of cases, the classification of the cell or particle requires a second level step requiring the use of numerical or categorical values from the first level in combination with a second level model.
    Type: Grant
    Filed: August 22, 2017
    Date of Patent: August 2, 2022
    Assignee: Iris International, Inc.
    Inventors: Carlos Ramirez, Steven Cadavid, Jindan Zhou
  • Patent number: 11268894
    Abstract: A flow cell includes a body and a flow channel. The body is formed out of blocks made of an uniaxial crystal material and joined to one another. The flow channel is formed inside the body, so that the flow cell is configured to be used to measure particles passing through the flow channel based on reception of scattered light generated from the particles. A crystallographic c-axis in a predetermined part of the body is configured to being substantially perpendicular to both a receiving direction and a polarization direction of the scattered light.
    Type: Grant
    Filed: December 24, 2020
    Date of Patent: March 8, 2022
    Assignee: RION CO., LTD.
    Inventors: Hiroaki Yaguchi, Yuki Yamakawa, Masaki Shimmura, Tomonobu Matsuda
  • Patent number: 11193872
    Abstract: A method of aligning a plurality of targets is provided. The method includes generating a plurality of targets. A third phase includes the plurality of targets. The method further includes combining a first phase, a second phase, and the third phase in a volume. The first phase, the second phase, and the third phase are substantially immiscible, and the third phase is in fluid communication with the first phase and the second phase, and the first phase, the second phase, and the third phase are operable to be in a configuration of the third phase between the first phase and the second phase in the volume.
    Type: Grant
    Filed: December 17, 2018
    Date of Patent: December 7, 2021
    Assignee: Life Technologies Corporation
    Inventors: Mark Andersen, Michael Pallas, Haopeng Wang
  • Patent number: 11175223
    Abstract: A system for measuring with the aid of light absorption spectrometry the concentration of one or more analytes in porewater in soil, the system comprising: one or more monitoring unit(s), each monitoring unit comprising a porewater sampler (1), an optical flow cell (2) with a tube connecting the liquid inlet port of said optical flow cell to said porewater sampler; and vacuum arrangement to enable extraction of porewater; at least one light source (5) for generating a light beam to be transmitted through said optical flow cell (2); and at least one detector (8) for obtaining spectral information from the beam exiting said optical flow cell. A method of measurement is also provided.
    Type: Grant
    Filed: December 5, 2017
    Date of Patent: November 16, 2021
    Inventors: Ofer Dahan, Shlomi Arnon, Elad Yeshno
  • Patent number: 11111595
    Abstract: The object of the present invention is such that a surface exchange of metal fine particles by Cu ions, or the like is inhibited in order to prevent formation of Artificial CuS or the like, in extraction and analysis of the metal fine particles (inclusions and precipitates) in a metal material by electrolytic corrosion in a solvent-based electrolytic solution, without significantly changing conventional extraction and analysis methods, and such that the metal deposited on the cathode is actively attached to the cathode so that the deposited metal does not become a contamination source.
    Type: Grant
    Filed: February 17, 2017
    Date of Patent: September 7, 2021
    Inventor: Kazumi Mizukami
  • Patent number: 11035774
    Abstract: A biosensor for detecting the presence of a target compound in a test solution is disclosed. The biosensor includes upper and lower carrier plates, a spacer film with a micro-channel, an inlet port upstream of the micro-channel, an outlet port downstream of the micro-channel, a micro-machined transceiver, and a first molecularly imprinted polymer layer for recognizing and binding the target compound. The micro-machined transceiver includes a micro-machined transmitter for generating an acoustic wave, and micro-machined receiver for generating an acoustic wave-induced voltage. An amplitude of the acoustic wave-induced voltage is varied in response to the concentration of the target compound.
    Type: Grant
    Filed: March 29, 2019
    Date of Patent: June 15, 2021
    Inventors: Chien-Chong Hong, Jheng-Ying Wu
  • Patent number: 10962563
    Abstract: Methods and systems are provided for measuring a velocity of a droplet passing through a microfluidic channel.
    Type: Grant
    Filed: January 11, 2019
    Date of Patent: March 30, 2021
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: Aaron Weber, Tony Hung, Sepehr Kiani
  • Patent number: 10921224
    Abstract: A system for detecting and analyzing particles in an air stream includes an inlet, a particle concentrator and a particle discriminator having an air channel with a cross-sectional geometry that changes within at least one of the inlet, particle concentrator and particle discriminator. The system may have a sheath air stage including a port for providing sample air, at least one sheath air inlet port for providing sheath air, and a sheath air combining region. The system may include an airflow compression stage having a varying air channel that narrows as the air stream traverses the airflow compression stage to pre-concentrate particles within an interior region of the air stream. The system may include an airflow expansion stage having an air channel that widens to slow the airstream and particle velocities. A portion of the air channel height may be narrowed to allow a larger thermophoretic force to be generated.
    Type: Grant
    Filed: November 13, 2018
    Date of Patent: February 16, 2021
    Inventors: David Woolsey, David William Burns
  • Patent number: 10908429
    Abstract: An extreme ultraviolet light generation system according to one aspect of the present disclosure includes: a pulse laser apparatus configured to output a pulse laser beam, the pulse laser beam being supplied to a predetermined region in a chamber in which plasma containing extreme ultraviolet light is to be generated; a sensor configured to detect a beam size of the pulse laser beam; an actuator configured to change the beam size; and a controller. The controller performs, based on a first algorithm, first control that controls the actuator by a first control amount in a beam size minifying direction when the beam size has exceeded a first upper limit threshold in one burst duration, and then performs, based on a second algorithm, second control that controls the actuator by a second control amount smaller than the first control amount so that the beam size becomes closer to a target value.
    Type: Grant
    Filed: April 20, 2020
    Date of Patent: February 2, 2021
    Assignee: Gigaphoton Inc.
    Inventors: Takayuki Yabu, Yuichi Nishimura
  • Patent number: 10894255
    Abstract: This invention relates to a method for separating blood cells comprising the steps of: (a) lysing red blood cells of a blood sample and diluting said sample; (b) providing a microfluidic device comprising a spiral-shaped flow channel having at least a first end and a second end, wherein said flow channel has two inlet ports at or near said first end and at least two outlet ports at or near said second end, wherein one of the two inlet ports is located at the inner wall of the spiral-shaped flow channel and the other inlet port is located at the outer wall of the spiral-shaped flow channel and at least one of the outlet ports is connected to a container allowing the storage of blood cells; (c) introducing the sample of step (a) into the inlet port located at the outer wall of the spiral-shaped flow channel and introducing a sheath fluid into the inlet port located at the inner wall of the spiral-shaped flow channel; (d) driving said sample and the sheath fluid through the spiral-shaped flow channel; and (e) re
    Type: Grant
    Filed: June 30, 2016
    Date of Patent: January 19, 2021
    Assignee: Nanyang Technological University
    Inventors: Han Wei Hou, Bernhard Otto Boehm, Hui Min Tay, Say Chye Joachim Loo
  • Patent number: 10866187
    Abstract: Provided are methods of assessing the cleanliness of a flow cell of a flow cytometric system. The provided methods include computing a ratio of post-flow cell and pre-flow cell light beam intensities and using such a ratio to assess the cleanliness of the flow cell. Flow cytometric systems capable of monitoring the cleanliness of a flow cell contained within the system are also provided.
    Type: Grant
    Filed: April 14, 2020
    Date of Patent: December 15, 2020
    Assignee: Abbott Laboratories
    Inventors: Svitlana Y. Berezhna, JrHung T Tsai, David Spalding, Mahesh R. Junnarkar, Chia-Fa Hsu
  • Patent number: 10815521
    Abstract: An electrochemical microarray chip to detect specific sequences of single-stranded DNA (ssDNA) or single-stranded RNA (ssRNA) target molecules in solution using a microarray of microspots of probe molecules immobilized on an electrode. The chip pertains to both regulating the immunospecific binding to the array of probes on the electrode and their subsequent detection on the microarray spots on the monolith electrode by electrochemical methods. The device can quantitatively measure the concentration of target molecules of specific sequence at high specificity and high sensitivity.
    Type: Grant
    Filed: March 12, 2018
    Date of Patent: October 27, 2020
    Inventors: Ravi Saraf, Abhijeet Prasad, Shobana Raghunath, Rahul Tevatia
  • Patent number: 10816450
    Abstract: A particle counter and classification system and method wherein a first stage magnetometer sensor subsystem for the fluid is tuned to detect and determine the size of ferrous and/or conducting particles in the fluid above a predetermined size. A pump is configured to drive a volume of the fluid through the first stage magnetometer sensor subsystem. A processing subsystem is responsive to the first stage magnetometer sensor subsystem and is configured to count the number of ferrous and/or conducting particles above the predetermined size based on the output of the first stage magnetometer sensor subsystem and to determine and report the concentration of the ferrous and/or conducting particles above the predetermined size as a function of the size of the particles, their number, and the volume of the fluid.
    Type: Grant
    Filed: December 14, 2018
    Date of Patent: October 27, 2020
    Assignee: Spectro Scientific, Inc.
    Inventors: Thomas G. Barraclough, Yuegang Zhao, Daniel Walsh
  • Patent number: 10782221
    Abstract: A system for determining a particle contamination and a method for determining a particle contamination in a measurement environment is provided in which individual particles in the measurement environment are detected (S1), wherein a) an estimate of the number of particles per volume in the measurement environment is ascertained (S2), b) an estimate of the number of particles per volume and characterization information describing the particle source in the measurement information are taken as a basis for ascertaining an output value for the particle contamination in the measurement environment (S3), and c) context-related data are made available and the characterization information is estimated on the basis of the available context-related data (S4).
    Type: Grant
    Filed: October 21, 2019
    Date of Patent: September 22, 2020
    Inventors: Stefan Weiss, Alexander Herrmann, Robert Wolf, Alexander Van Der Lee, Wolfram Johannes Martin Lyda, Balazs Jatekos, Robert Weiss, Sören Sofke, Hans Spruit, Jens-Alrik Adrian, Matthias Falk, Dominik Moser
  • Patent number: 10723466
    Abstract: A device for determining the water content in the atmosphere comprising: a laser transmitter suitable for transmitting a laser beam for illuminating particles of water and/or ice present in the atmosphere, a first out-of-focus imager having a first collection angle suitable for capturing at least one first representative image of the particles, and processing unit in communication connection with the first image. The device further comprises a second out-of-focus imager having a second collection angle suitable for capturing at least one second image. The processing unit is in communication connection with the second imager, the processing unit being suitable for processing the first and second images in order to determine the water content in the atmosphere.
    Type: Grant
    Filed: March 23, 2016
    Date of Patent: July 28, 2020
    Inventors: Manuel Thorez, Laurent Paszkiewicz
  • Patent number: 10718703
    Abstract: An airborne or liquid particle sensor with a number of advanced features is disclosed. The sensor includes an output channel generating an electrical signal for a particle passing through the sensor, where the electrical signal includes information related to the pulse. The information is processed by the sensor to determine a value that indicates a more accurate particle mass for a sample period than the average mass.
    Type: Grant
    Filed: June 12, 2017
    Date of Patent: July 21, 2020
    Assignee: Particles Plus, Inc.
    Inventors: David Pariseau, Adam Giandomenico
  • Patent number: 10718719
    Abstract: Embodiments include devices and methods for detecting particles in a wafer processing tool. In an embodiment, a particle monitoring device having a wafer form factor includes several micro sensors capable of operating in all pressure regimes, e.g., under vacuum conditions. The particle monitoring device may include a clock to output a time value when a parameter of a micro sensor changes in response to receiving a particle within a chamber of the wafer processing tool. A location of the micro sensor or the time value may be used to determine a source of the particle. Other embodiments are also described and claimed.
    Type: Grant
    Filed: July 31, 2018
    Date of Patent: July 21, 2020
    Assignee: Applied Materials, Inc.
    Inventors: Leonard Tedeschi, Kartik Ramaswamy
  • Patent number: 10705009
    Abstract: Described are systems and methods for optical characterization of inclusions, such as solids and liquids, in liquid samples. An inclusion characterization system may include a radiation source, a radiation detector, a sample optical cell, and a sample delivery mechanism. The radiation detector may be configured to perform time resolved measurements. The sample may be delivered to the sample optical cell by the sample delivery mechanism at a flow rate set for preserving the sample integrity (i.e., the transport rate). The inclusion characterization in the sample may be performed at flow rates set for sample analysis (i.e., the analysis rate). The analysis rate may differ from the transport rate. The rate difference may be achieved by diverting only a portion of the overall sample into the sample optical cell. Also provided are examples of disengagement of sample transport and analysis flow rates.
    Type: Grant
    Filed: February 4, 2019
    Date of Patent: July 7, 2020
    Inventor: Rashid Mavliev
  • Patent number: 10638966
    Abstract: There is provided a urine analysis device for bed side monitoring of a patient, comprising: an inlet sized and shaped for fluid communication with a urine collecting tube that receives urine from a patient; a drip chamber through which the urine flows towards an outlet; at least one sensor that analyzes each drop of urine and estimates a respective volume of each drop; a timing element that measures a reference time for each drop; a program store storing code; and at least one processing unit coupled to the program store for implementing the stored code, the code comprising: code to calculate a urine output flow rate of the urine output flowing through the chamber according to the estimated volume of each drop of the urine and the reference time for each drop; and code to output the urine output flow rate.
    Type: Grant
    Filed: August 4, 2016
    Date of Patent: May 5, 2020
    Assignee: ART Healthcare Ltd.
    Inventors: Liron Elia, Gavriel J. Iddan
  • Patent number: 10634660
    Abstract: A technology of measuring an electrical characteristic of a blood sample is provided that allows easy introduction, into an existing blood test system, a technique of obtaining information on a blood sample from an electrical characteristic of the blood sample. The technology provides a device for measuring an electrical characteristic of a blood sample, the device including: a mixing unit configured to mix a blood cell component and a plasma component on the basis of the composition ratio between the blood cell component and the plasma component in a blood sample; and a blood sample measurement unit configured to measure an electrical characteristic of a blood sample obtained by mixing by the mixing unit.
    Type: Grant
    Filed: February 29, 2016
    Date of Patent: April 28, 2020
    Inventors: Marcaurele Brun, Isao Hidaka
  • Patent number: 10605816
    Abstract: This disclosure describes a magnetic-field image sensor and method of use. In accordance with implementations of the magnetic-field image sensor, a sample can be placed on top of the magnetic field image sensor. An image of the magnetic nanoparticles or superparamagnetic nanoparticles can be created immediately afterwards based upon detection of a change in magnetic field caused by the magnetic nanoparticles or superparamagnetic nanoparticles. From this image, computer imaging algorithms can determine attributes (e.g., size, shape, type, quantity, distribution, etc.) of the target entity.
    Type: Grant
    Filed: December 17, 2015
    Date of Patent: March 31, 2020
    Inventors: Ronald B. Koo, Henry Grage
  • Patent number: 10564156
    Abstract: The use of at least one colorant is provided in order to improve the detection of a signal corresponding to the presence of an analyte in a dot analysis method, in particular when the detection of the signal takes place in the presence of a liquid phase. Also provided is a dot analysis method that can be used to improve the detection of a signal corresponding to the presence of an analyte, in the presence of a liquid phase containing at least one colorant.
    Type: Grant
    Filed: April 8, 2015
    Date of Patent: February 18, 2020
    Inventors: Bertrand Merandon, Christophe Vedrine
  • Patent number: 10564269
    Abstract: For test/calibration of an electro-optic range-finding device, one or more fiber bundles each are selected to have a length corresponding to predetermined time-of-flight for light pulses. An input end is positioned proximate to the laser aperture of the range-finding device to receive a portion of light emitted through the laser aperture, and the output end is positioned to emit light from the respective fiber bundle through the detector aperture of the range-finding device. A fiber attenuator is connected along each fiber of the one or more fiber bundles to attenuate an amplitude of light propagating through the respective fiber by an amount corresponding to a target of known reflectance and distance. The one or more fiber bundles are each coiled to reduce a linear distance over which the one or more fiber bundles extend. The one or more fiber bundles may each comprise a plurality of fibers.
    Type: Grant
    Filed: February 14, 2018
    Date of Patent: February 18, 2020
    Assignee: Raytheon Company
    Inventors: John Crawford, John Millard
  • Patent number: 10527830
    Abstract: An optical relay system includes four or more reflective optical elements oriented in a tilted configuration. Each of the four or more reflective optical elements is tilted about one of four or more tilt axes. Further, the four or more tilt axes are oriented to correct for aberrations induced by the tilted configuration.
    Type: Grant
    Filed: December 27, 2016
    Date of Patent: January 7, 2020
    Assignee: KLA-Tencor Corporation
    Inventors: Andrew V. Hill, Gregory R. Brady
  • Patent number: 10455127
    Abstract: A movement detection device, including a multi-element photodiode, the multi-element photodiode comprising a plurality of pixels, referred to as megapixels, and, for at least one megapixel of the multi-element photodiode, a mask partially obscuring a sensitive zone of said megapixel, the mask consisting of a plurality of zones including at least one opaque zone and at least one transparent zone, an opaque zone being able to prevent a light beam from fully reaching portions of the sensitive zone of the megapixel corresponding to the opaque zone, a transparent zone being able to allow a light beam to reach a portion of the sensitive surface of the megapixel corresponding to the transparent zone, each opaque zone having at least one adjacent transparent zone so as to obtain an alternation of opaque zones and transparent zones in the mask.
    Type: Grant
    Filed: July 16, 2015
    Date of Patent: October 22, 2019
    Inventor: Marc Bousquet
  • Patent number: 10401482
    Abstract: An optoelectronic sensor for measuring a distance comprises a light transmitter (20) for transmitting a sequence of individual light pulses (22) and a light receiver (26) for receiving the individual light pulses (24). An individual time of flight measuring unit (28) determines a sequence of individual times of flight of the individual light pulses (22, 24) as the duration between a transmission point in time and its reception point in time. An evaluation unit (30, 32) accumulates individual times of flight and determines a common measurement value for the distance from the accumulated individual times of flight. The evaluation unit (30) comprises a filter (36) for accumulating an individual time of flight only if it coincides, within a time window, with a preceding individual time of flight.
    Type: Grant
    Filed: November 4, 2016
    Date of Patent: September 3, 2019
    Assignee: SICK AG
    Inventors: Stefan Kienzler, Martin Köhl, Kai Waslowski, Ulrich Zwölfer
  • Patent number: 10379029
    Abstract: A flow cell for particle processing such as particle sorting, may be operatively engaged to a particle processing apparatus. The fluid contact surfaces of the flow cell may be fully enclosed. Further, the flow cell may encapsulate all fluid contact surfaces in the particle processing apparatus. The enclosing or encapsulation of the fluid contact surfaces insures, improves or promotes operator isolation and/or product isolation. The flow cell may employ any suitable technique for processing particles. The flow cell may be disposable and suitable for use in droplet sorting. The flow cell may include an operatively sealed sort chamber having a particle stream focusing region, an orifice, an interrogation zone and a sorting region.
    Type: Grant
    Filed: September 18, 2013
    Date of Patent: August 13, 2019
    Assignee: CYTONOME/ST, LLC
    Inventors: Johnathan Charles Sharpe, Rudolf Hulspas, Kristopher Scott Buchanan
  • Patent number: 10352841
    Abstract: A dynamic light scattering apparatus includes a source configured for irradiating a sample with primary electromagnetic radiation, a detector configured for detecting secondary electromagnetic radiation generated by scattering the primary electromagnetic radiation at the sample, a refraction index determination unit including a movable optical element and configured to determine information indicative of a refraction index of the sample based on measurements of the secondary electromagnetic radiation for a plurality of different positions of the movable optical element, and a particle size determining unit configured to determine information indicative of particle size of particles in the sample by analyzing the detected secondary electromagnetic radiation and taking into account the refraction index determined by the refraction index determining unit.
    Type: Grant
    Filed: November 20, 2015
    Date of Patent: July 16, 2019
    Assignee: Anton Paar GmbH
    Inventor: Christian Moitzi
  • Patent number: 10352844
    Abstract: An airborne, gas, or liquid particle sensor with multiple particle sensor blocks in a single particle counter. Each sensor would sample a portion of the incoming airstream, or possibly a separate airstream. The various counters could be used separately or in concert.
    Type: Grant
    Filed: March 15, 2014
    Date of Patent: July 16, 2019
    Assignee: Particles Plus, Inc.
    Inventor: David Pariseau
  • Patent number: 10339778
    Abstract: A chamberless indoor air quality monitor system includes a detector body. A resistive heater is operatively connected to the detector body. An active temperature sensor operatively connected to the resistive heater and operatively connected to an outer surface of the detector body configured to take an active temperature measurement. A method for measuring temperature in a chamberless indoor air quality monitor system includes generating an active temperature measurement with an active temperature sensor operatively connected to an outer surface of the detector body. The method includes heating the active temperature sensor with a resistive heater operatively connected to the detector body. The method includes comparing the active temperature measurements to one another to generate a corrected active temperature measurement based on a temperature difference over time between one or more of the active temperature measurements.
    Type: Grant
    Filed: January 15, 2018
    Date of Patent: July 2, 2019
    Assignee: Kidde Technologies, Inc.
    Inventors: Michael J. Birnkrant, David L. Lincoln
  • Patent number: 10265884
    Abstract: A kneader includes a kneader main body including a casing including a kneading chamber and a kneading portion that is disposed in the casing and kneads a material in the kneading chamber. The material supplied to the kneading chamber includes a resin material, an inorganic additive added to the resin material, and a coupling agent for enhancing affinity of the inorganic additive for the resin material. The kneader further includes a kneading monitoring portion that monitors a kneading state of the material by detecting a reaction product that is generated by a reaction between the coupling agent and the inorganic additive.
    Type: Grant
    Filed: February 26, 2014
    Date of Patent: April 23, 2019
    Assignee: Kobe Steel, Ltd.
    Inventor: Hodaka Miura
  • Patent number: 10228315
    Abstract: A method for measuring particle size distribution in a fluid material, involving inserting a laser beam instrument directly in the fluid flow line, wherein the laser beam instrument focuses a laser beam on a window directly coupled with the fluid flow line, wherein the fluid flow line comprises a fluid having a plurality of particles of different sizes, measuring a diameter of at least one particle in the fluid flow line by reflectance of the at least one particle as the at least one particle passes through the focused laser beam, and determining a duration of reflection of the at least one particle, and obtaining a count of particles in each of a pre-set range group of particle sizes, wherein the count of particles is used to determine particle size distribution in the fluid flow line.
    Type: Grant
    Filed: April 14, 2015
    Date of Patent: March 12, 2019
    Inventors: Egil Ronaes, Michael A. Freeman
  • Patent number: 10215771
    Abstract: Methods and systems are provided for measuring a velocity of a droplet passing through a microfluidic channel.
    Type: Grant
    Filed: November 4, 2015
    Date of Patent: February 26, 2019
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: Aaron Weber, Tony Hung, Sepehr Kiani
  • Patent number: 10088660
    Abstract: A system is described to facilitate the characterization of particles within a fluid contained in a vessel using an illumination system that directs source light through each vessel. One or more optical elements may be implemented to refract the source light and to illuminate the entire volume of the vessel. As the refracted source light passes through the vessel and interacts with particles suspended in the fluid, scattered light is produced and directed to an imager, while the refracted source light is diverted away from the imager to prevent the source light from drowning out the scattered light. The system can therefore advantageously utilize an imager with a large depth of field to accurately image the entire volume of fluid at the same time, facilitating the determination of the number and size of particles suspended in the fluid.
    Type: Grant
    Filed: February 10, 2017
    Date of Patent: October 2, 2018
    Assignee: AMGEN INC.
    Inventors: Dmitry Fradkin, Graham F. Milne, Thomas Clark Pearson
  • Patent number: 10078079
    Abstract: This invention relates to a device for detecting an analyte in a sample comprising: a radiation source adapted to generate a series of pulses of electromagnetic radiation; a transducer having a pyroelectric or piezoelectric element and electrodes which is capable of transducing energy generated by non-radiative decay into an electrical signal; a detector which is capable of detecting the electrical signal generated by the transducer; a first reagent proximal to the transducer, the first reagent having a binding site which is capable of binding a labelled reagent proportionally to the concentration of the analyte in the sample, which labelled reagent being capable of absorbing the electromagnetic radiation generated by the radiation source to generate energy by non-radiative decay; a second reagent proximal to the transducer, the second reagent having a lower affinity for the labelled reagent under the conditions of the assay than the first reagent; and a third reagent proximal to the transducer, the third rea
    Type: Grant
    Filed: April 5, 2012
    Date of Patent: September 18, 2018
    Assignee: Vivacta Limited
    Inventors: Steve Ross, Julie Richards, Tim Carter
  • Patent number: 9989462
    Abstract: This invention relates to optical particle counters and methods capable of effectively distinguishing signals generated from particle light scattering from sources of noise. Embodiments of the invention, for example, use multisensory detector configurations for identifying and distinguishing signals corresponding to fluctuations in laser intensity from signals corresponding to particle light scattering for the detection and characterization of submicron particles. In an embodiment, for example, methods and systems of the invention compare signals from different detector elements of a detector array to identify and characterize noise events, such as noise generated from laser intensity instability, thereby allow for the detection and characterization of smaller particles. The system and methods of the present invention, thus, provide an effective means of reducing false positives caused by noise or interference while allowing for very sensitive particle detection.
    Type: Grant
    Filed: April 1, 2016
    Date of Patent: June 5, 2018
    Inventors: James Lumpkin, Matthew Melton
  • Patent number: 9885648
    Abstract: A particle detecting apparatus has a condensing and growing unit to condense and grow a condensing component over particles contained in a gas while the gas imported through an inflow port is transported from a low temperature portion to a high temperature portion, a particle detector to detect a concentration of the particles contained in the gas discharged from an outflow port of the condensing and growing unit, a particle feeder to feed, to the inflow port of the condensing and growing unit, a test gas containing test particles whose particle diameter and the number of particles per unit volume are known, and a first determinator to determine whether a concentration of the test particles contained in the test gas detected by the particle detector has a predetermined value.
    Type: Grant
    Filed: March 9, 2016
    Date of Patent: February 6, 2018
    Assignee: Toshiba Memory Corporation
    Inventors: Masaki Hirano, Yuichi Kuroda, Kenichi Otsuka
  • Patent number: 9885591
    Abstract: A fiber optic sensor to determine a property in an environment with a temperature exceeding 150 degrees Celsius includes a light source to emit broadband light, an etendue of the light source being less than 1000 square micro meter-steradians (?m2 sr), and an optical fiber to carry incident light based on the broadband light and a reflection resulting from the incident light. A photodetector detects a resultant light based on the reflection and outputs an electrical signal, and a processor processes the electrical signal from the photodetector to determine the property.
    Type: Grant
    Filed: March 18, 2016
    Date of Patent: February 6, 2018
    Assignee: BAKER HUGHES, a GE company, LLC
    Inventor: Rocco DiFoggio
  • Patent number: 9851301
    Abstract: A method for automated identification of a state of a sample such as, for example, for identifying whether or not the sample was centrifuged is presented. A device for analyzing samples and a laboratory automation system are also presented in which the method is applied.
    Type: Grant
    Filed: March 25, 2016
    Date of Patent: December 26, 2017
    Assignee: Roche Diagnostics Operations, Inc.
    Inventor: Steffen Mueller
  • Patent number: 9833795
    Abstract: A method and system for separating multicomponent fluids into components having different buoyancies. A flow shaping member has a helical channel that imparts a helical motion to the fluid, and a separation chamber for separating the moving fluid into a helically moving heavier flow portion and a more buoyant portion along the central axis. A flow receiving member has a first collection horn with a mouth arranged to collect the higher buoyancy fluid and direct the fluid to an outlet. At least one other fluid passageway for carrying lower buoyancy fluid has an inlet surrounding of the collection horn, and directs the fluid to a separate outlet at an end of the separator. Additional collection horns can be arranged concentrically around the first collection horn to collect intermediate buoyancy flows. Cascaded fluid separators can concentrate the higher buoyancy fluid or the denser fluid.
    Type: Grant
    Filed: May 23, 2016
    Date of Patent: December 5, 2017
    Assignee: The United States of America, as represented by the Secretary of the Navy
    Inventors: John E. Tucker, Paul L. Howard, John F. Reintjes
  • Patent number: 9778018
    Abstract: Embodiments herein include swept-source interferometric imaging systems employing arbitrary sweep patterns in which a swept-source is swept over a continuous spectral range where the variation of wavelength over time is noncontinuous. Embodiments include sweep patterns that result in reduction of signals from moving scatterers and where the sweep is synchronized with the dead time of the camera.
    Type: Grant
    Filed: February 3, 2015
    Date of Patent: October 3, 2017
    Inventors: Tilman Schmoll, Matthew J. Everett
  • Patent number: 9719914
    Abstract: An embodiment provides a method, including: operating a motor to position sample fluid within a fluid channel of a cuvette; transmitting light through an optical chamber of the cuvette; measuring a value of received light that has been transmitted through the optical chamber; comparing the measured value of light to one or more thresholds; determining a position of the sample fluid within the fluid channel based on a comparison from the comparing step; and generating a response based upon the position of the sample fluid with the fluid channel. Other aspects are described and claimed.
    Type: Grant
    Filed: October 2, 2015
    Date of Patent: August 1, 2017
    Assignee: Hach Company
    Inventors: Jim Duncan, Aria Farjam, Jim Harbridge, Brian Harmon, Ulrich Lundgreen, Darren MacFarland, Leon Moore, Perry Palumbo, William Louis Pherigo, Jr., Robert Stoughton, Luke Waaler
  • Patent number: 9703757
    Abstract: Systems and methods for automatically determining a content item size may be based on a size of a viewport and a width of a parent element. A script may be configured to determine a size of a viewport, determine a width of a parent element of a resource, and determine a content item size based, at least in part, on the size of the view port and the width of the parent element. A dimension of the determined content item size may be used by a content item selection system to determine a set of content items. A content item selection system may select a content item from the determined set of content items and serve data to effect display of the selected content item in the parent element with the resource.
    Type: Grant
    Filed: October 8, 2013
    Date of Patent: July 11, 2017
    Assignee: Google Inc.
    Inventors: Graeme John Rimmer, Lewis Jay Hemens
  • Patent number: 9683940
    Abstract: A particle detecting device includes: a light measuring instrument that measures measured values for intensities of first, second, and third lights of mutually differing wavelengths, produced by particles to be measured; a boundary information storing portion that stores a non-linear discriminating boundary for separating a class of a first classification of particles and a class of a second classification of particles; and a particle classifying portion that classifies the particle being measured into either of the classifications for the first and second classifications of particles, based on measured values for the intensities of the first through third lights and on the discriminating boundary.
    Type: Grant
    Filed: June 25, 2015
    Date of Patent: June 20, 2017
    Inventors: Tomoki Hosoi, Daisuke Obara, Masashi Furuya, Seiichirou Kinugasa
  • Patent number: 9645377
    Abstract: A compressive imaging system includes an illumination system arranged to illuminate an object of interest with illumination light, and a detection system configured to detect at least a portion of the illumination light after being at least one of reflected from, scattered from, or transmitted through the object of interest or to detect fluorescent light from the object of interest and to provide an imaging signal. The compressive imaging system further includes an image processing system configured to communicate with the detection system to receive the imaging signal. The illumination light from the illumination system comprises a plurality of light pulses such that each light pulse has a preselected spectrum that is distinguishable from spectra of all other pulses. The image processing system is configured to form an image of the object of interest using information concerning the preselected spectra of the plurality of light pulses.
    Type: Grant
    Filed: February 8, 2016
    Date of Patent: May 9, 2017
    Inventors: Bryan T. Bosworth, Mark A. Foster, Jasper R. Stroud, Trac Tran, Sang Chin, Dung Tran
  • Patent number: 9626489
    Abstract: Systems and methods are described that protect intellectual property rights in connection with 3-dimensional printing processes. In certain embodiments, an object a user would like to render with a 3-dimensional printing device may be compared with one or more managed objects having certain associated intellectual property rights. If the object is found to be similar to a managed object (e.g., similar in shape, function, composition, etc.), policy associated with the managed object may be enforced in connection with rendering the object. In this manner, intellectual property rights associated with the managed objects may be enforced.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: April 18, 2017
    Assignee: Intertrust Technologies Corporation
    Inventor: Jarl A. Nilsson
  • Patent number: 9542793
    Abstract: An optical sensing system for detecting objects passing through a volume of interest, wherein the sensing system has an emitter and a detector. The detector detects motion of object shadows generated as the object passes through the volume of interest between the emitter and detector. Motion detection algorithms, using computed motion vectors of the detected object, logically determine whether an object has traveled completely through the detection space, and can be used to discriminate a specific outcomes and/or impediments.
    Type: Grant
    Filed: November 27, 2013
    Date of Patent: January 10, 2017
    Assignee: Softronics, Ltd.
    Inventors: Robert Sternowski, James G. Sliney, Jr.
  • Patent number: 9513198
    Abstract: A method and apparatus for measuring dissolved residue concentrations and particulate residue particle concentrations and size distribution in liquids, particularly colloidal suspensions. The method involves separating dissolved and particulate residues in liquids for subsequent analysis of the residue species. The method includes the steps of forming an aerosol from the liquid sample to be analyzed, evaporating the droplets in the aerosol to dryness, detecting and sizing the particles, and determining the liquid volumetric inspection rate. An apparatus for separating dissolved and particulate residues in liquids for determination of the concentrations of the two residue species as well as the size distribution of the particulate species is also disclosed. The apparatus includes a droplet former, a dryer communicatively connected to the droplet former, and a detector communicatively connected to the evaporator for detecting and sizing particles.
    Type: Grant
    Filed: September 19, 2013
    Date of Patent: December 6, 2016
    Assignee: CT Associates, Inc.
    Inventors: Donald C. Grant, Mark R. Litchy
  • Patent number: 9500531
    Abstract: A wavefront sensing technique using Polarization Rotation INTerferometry (PRINT) provides a self-referencing, high-resolution, direct measurement of the spatially dependent phase profile of a given optical beam. A self-referencing technique is used to create a reference beam in the orthogonal polarization and a polarization measurement to measure the spatial-dependent polarization parameters to directly determine the absolute phase profile of the beam under test. A high-resolution direct measurement of the spatially-resolved phase profile of one or more optical beams is realized.
    Type: Grant
    Filed: March 25, 2014
    Date of Patent: November 22, 2016
    Assignee: University of Rochester
    Inventors: Zhimin Shi, Robert W. Boyd, Mohammad Mirhosseini, Mehul Malik