Abstract: Methods and systems are provided for measuring a velocity of a droplet passing through a microfluidic channel.

Abstract: A system for detecting and analyzing particles in an air stream includes an inlet, a particle concentrator and a particle discriminator having an air channel with a cross-sectional geometry that changes within at least one of the inlet, particle concentrator and particle discriminator. The system may have a sheath air stage including a port for providing sample air, at least one sheath air inlet port for providing sheath air, and a sheath air combining region. The system may include an airflow compression stage having a varying air channel that narrows as the air stream traverses the airflow compression stage to pre-concentrate particles within an interior region of the air stream. The system may include an airflow expansion stage having an air channel that widens to slow the airstream and particle velocities. A portion of the air channel height may be narrowed to allow a larger thermophoretic force to be generated.

Abstract: An extreme ultraviolet light generation system according to one aspect of the present disclosure includes: a pulse laser apparatus configured to output a pulse laser beam, the pulse laser beam being supplied to a predetermined region in a chamber in which plasma containing extreme ultraviolet light is to be generated; a sensor configured to detect a beam size of the pulse laser beam; an actuator configured to change the beam size; and a controller. The controller performs, based on a first algorithm, first control that controls the actuator by a first control amount in a beam size minifying direction when the beam size has exceeded a first upper limit threshold in one burst duration, and then performs, based on a second algorithm, second control that controls the actuator by a second control amount smaller than the first control amount so that the beam size becomes closer to a target value.

Abstract: This invention relates to a method for separating blood cells comprising the steps of: (a) lysing red blood cells of a blood sample and diluting said sample; (b) providing a microfluidic device comprising a spiral-shaped flow channel having at least a first end and a second end, wherein said flow channel has two inlet ports at or near said first end and at least two outlet ports at or near said second end, wherein one of the two inlet ports is located at the inner wall of the spiral-shaped flow channel and the other inlet port is located at the outer wall of the spiral-shaped flow channel and at least one of the outlet ports is connected to a container allowing the storage of blood cells; (c) introducing the sample of step (a) into the inlet port located at the outer wall of the spiral-shaped flow channel and introducing a sheath fluid into the inlet port located at the inner wall of the spiral-shaped flow channel; (d) driving said sample and the sheath fluid through the spiral-shaped flow channel; and (e) re

Abstract: Provided are methods of assessing the cleanliness of a flow cell of a flow cytometric system. The provided methods include computing a ratio of post-flow cell and pre-flow cell light beam intensities and using such a ratio to assess the cleanliness of the flow cell. Flow cytometric systems capable of monitoring the cleanliness of a flow cell contained within the system are also provided.

Abstract: A particle counter and classification system and method wherein a first stage magnetometer sensor subsystem for the fluid is tuned to detect and determine the size of ferrous and/or conducting particles in the fluid above a predetermined size. A pump is configured to drive a volume of the fluid through the first stage magnetometer sensor subsystem. A processing subsystem is responsive to the first stage magnetometer sensor subsystem and is configured to count the number of ferrous and/or conducting particles above the predetermined size based on the output of the first stage magnetometer sensor subsystem and to determine and report the concentration of the ferrous and/or conducting particles above the predetermined size as a function of the size of the particles, their number, and the volume of the fluid.

Abstract: An electrochemical microarray chip to detect specific sequences of single-stranded DNA (ssDNA) or single-stranded RNA (ssRNA) target molecules in solution using a microarray of microspots of probe molecules immobilized on an electrode. The chip pertains to both regulating the immunospecific binding to the array of probes on the electrode and their subsequent detection on the microarray spots on the monolith electrode by electrochemical methods. The device can quantitatively measure the concentration of target molecules of specific sequence at high specificity and high sensitivity.

Abstract: A system for determining a particle contamination and a method for determining a particle contamination in a measurement environment is provided in which individual particles in the measurement environment are detected (S1), wherein a) an estimate of the number of particles per volume in the measurement environment is ascertained (S2), b) an estimate of the number of particles per volume and characterization information describing the particle source in the measurement information are taken as a basis for ascertaining an output value for the particle contamination in the measurement environment (S3), and c) context-related data are made available and the characterization information is estimated on the basis of the available context-related data (S4).

Abstract: A device for determining the water content in the atmosphere comprising: a laser transmitter suitable for transmitting a laser beam for illuminating particles of water and/or ice present in the atmosphere, a first out-of-focus imager having a first collection angle suitable for capturing at least one first representative image of the particles, and processing unit in communication connection with the first image. The device further comprises a second out-of-focus imager having a second collection angle suitable for capturing at least one second image. The processing unit is in communication connection with the second imager, the processing unit being suitable for processing the first and second images in order to determine the water content in the atmosphere.

Abstract: Embodiments include devices and methods for detecting particles in a wafer processing tool. In an embodiment, a particle monitoring device having a wafer form factor includes several micro sensors capable of operating in all pressure regimes, e.g., under vacuum conditions. The particle monitoring device may include a clock to output a time value when a parameter of a micro sensor changes in response to receiving a particle within a chamber of the wafer processing tool. A location of the micro sensor or the time value may be used to determine a source of the particle. Other embodiments are also described and claimed.

Abstract: An airborne or liquid particle sensor with a number of advanced features is disclosed. The sensor includes an output channel generating an electrical signal for a particle passing through the sensor, where the electrical signal includes information related to the pulse. The information is processed by the sensor to determine a value that indicates a more accurate particle mass for a sample period than the average mass.

Abstract: Described are systems and methods for optical characterization of inclusions, such as solids and liquids, in liquid samples. An inclusion characterization system may include a radiation source, a radiation detector, a sample optical cell, and a sample delivery mechanism. The radiation detector may be configured to perform time resolved measurements. The sample may be delivered to the sample optical cell by the sample delivery mechanism at a flow rate set for preserving the sample integrity (i.e., the transport rate). The inclusion characterization in the sample may be performed at flow rates set for sample analysis (i.e., the analysis rate). The analysis rate may differ from the transport rate. The rate difference may be achieved by diverting only a portion of the overall sample into the sample optical cell. Also provided are examples of disengagement of sample transport and analysis flow rates.

Abstract: There is provided a urine analysis device for bed side monitoring of a patient, comprising: an inlet sized and shaped for fluid communication with a urine collecting tube that receives urine from a patient; a drip chamber through which the urine flows towards an outlet; at least one sensor that analyzes each drop of urine and estimates a respective volume of each drop; a timing element that measures a reference time for each drop; a program store storing code; and at least one processing unit coupled to the program store for implementing the stored code, the code comprising: code to calculate a urine output flow rate of the urine output flowing through the chamber according to the estimated volume of each drop of the urine and the reference time for each drop; and code to output the urine output flow rate.

Abstract: A technology of measuring an electrical characteristic of a blood sample is provided that allows easy introduction, into an existing blood test system, a technique of obtaining information on a blood sample from an electrical characteristic of the blood sample. The technology provides a device for measuring an electrical characteristic of a blood sample, the device including: a mixing unit configured to mix a blood cell component and a plasma component on the basis of the composition ratio between the blood cell component and the plasma component in a blood sample; and a blood sample measurement unit configured to measure an electrical characteristic of a blood sample obtained by mixing by the mixing unit.

Abstract: This disclosure describes a magnetic-field image sensor and method of use. In accordance with implementations of the magnetic-field image sensor, a sample can be placed on top of the magnetic field image sensor. An image of the magnetic nanoparticles or superparamagnetic nanoparticles can be created immediately afterwards based upon detection of a change in magnetic field caused by the magnetic nanoparticles or superparamagnetic nanoparticles. From this image, computer imaging algorithms can determine attributes (e.g., size, shape, type, quantity, distribution, etc.) of the target entity.

Abstract: For test/calibration of an electro-optic range-finding device, one or more fiber bundles each are selected to have a length corresponding to predetermined time-of-flight for light pulses. An input end is positioned proximate to the laser aperture of the range-finding device to receive a portion of light emitted through the laser aperture, and the output end is positioned to emit light from the respective fiber bundle through the detector aperture of the range-finding device. A fiber attenuator is connected along each fiber of the one or more fiber bundles to attenuate an amplitude of light propagating through the respective fiber by an amount corresponding to a target of known reflectance and distance. The one or more fiber bundles are each coiled to reduce a linear distance over which the one or more fiber bundles extend. The one or more fiber bundles may each comprise a plurality of fibers.

Abstract: The use of at least one colorant is provided in order to improve the detection of a signal corresponding to the presence of an analyte in a dot analysis method, in particular when the detection of the signal takes place in the presence of a liquid phase. Also provided is a dot analysis method that can be used to improve the detection of a signal corresponding to the presence of an analyte, in the presence of a liquid phase containing at least one colorant.

Abstract: An optical relay system includes four or more reflective optical elements oriented in a tilted configuration. Each of the four or more reflective optical elements is tilted about one of four or more tilt axes. Further, the four or more tilt axes are oriented to correct for aberrations induced by the tilted configuration.

Abstract: A movement detection device, including a multi-element photodiode, the multi-element photodiode comprising a plurality of pixels, referred to as megapixels, and, for at least one megapixel of the multi-element photodiode, a mask partially obscuring a sensitive zone of said megapixel, the mask consisting of a plurality of zones including at least one opaque zone and at least one transparent zone, an opaque zone being able to prevent a light beam from fully reaching portions of the sensitive zone of the megapixel corresponding to the opaque zone, a transparent zone being able to allow a light beam to reach a portion of the sensitive surface of the megapixel corresponding to the transparent zone, each opaque zone having at least one adjacent transparent zone so as to obtain an alternation of opaque zones and transparent zones in the mask.

Abstract: An optoelectronic sensor for measuring a distance comprises a light transmitter (20) for transmitting a sequence of individual light pulses (22) and a light receiver (26) for receiving the individual light pulses (24). An individual time of flight measuring unit (28) determines a sequence of individual times of flight of the individual light pulses (22, 24) as the duration between a transmission point in time and its reception point in time. An evaluation unit (30, 32) accumulates individual times of flight and determines a common measurement value for the distance from the accumulated individual times of flight. The evaluation unit (30) comprises a filter (36) for accumulating an individual time of flight only if it coincides, within a time window, with a preceding individual time of flight.

Abstract: A flow cell for particle processing such as particle sorting, may be operatively engaged to a particle processing apparatus. The fluid contact surfaces of the flow cell may be fully enclosed. Further, the flow cell may encapsulate all fluid contact surfaces in the particle processing apparatus. The enclosing or encapsulation of the fluid contact surfaces insures, improves or promotes operator isolation and/or product isolation. The flow cell may employ any suitable technique for processing particles. The flow cell may be disposable and suitable for use in droplet sorting. The flow cell may include an operatively sealed sort chamber having a particle stream focusing region, an orifice, an interrogation zone and a sorting region.

Abstract: An airborne, gas, or liquid particle sensor with multiple particle sensor blocks in a single particle counter. Each sensor would sample a portion of the incoming airstream, or possibly a separate airstream. The various counters could be used separately or in concert.

Abstract: A dynamic light scattering apparatus includes a source configured for irradiating a sample with primary electromagnetic radiation, a detector configured for detecting secondary electromagnetic radiation generated by scattering the primary electromagnetic radiation at the sample, a refraction index determination unit including a movable optical element and configured to determine information indicative of a refraction index of the sample based on measurements of the secondary electromagnetic radiation for a plurality of different positions of the movable optical element, and a particle size determining unit configured to determine information indicative of particle size of particles in the sample by analyzing the detected secondary electromagnetic radiation and taking into account the refraction index determined by the refraction index determining unit.

Abstract: A chamberless indoor air quality monitor system includes a detector body. A resistive heater is operatively connected to the detector body. An active temperature sensor operatively connected to the resistive heater and operatively connected to an outer surface of the detector body configured to take an active temperature measurement. A method for measuring temperature in a chamberless indoor air quality monitor system includes generating an active temperature measurement with an active temperature sensor operatively connected to an outer surface of the detector body. The method includes heating the active temperature sensor with a resistive heater operatively connected to the detector body. The method includes comparing the active temperature measurements to one another to generate a corrected active temperature measurement based on a temperature difference over time between one or more of the active temperature measurements.

Abstract: A kneader includes a kneader main body including a casing including a kneading chamber and a kneading portion that is disposed in the casing and kneads a material in the kneading chamber. The material supplied to the kneading chamber includes a resin material, an inorganic additive added to the resin material, and a coupling agent for enhancing affinity of the inorganic additive for the resin material. The kneader further includes a kneading monitoring portion that monitors a kneading state of the material by detecting a reaction product that is generated by a reaction between the coupling agent and the inorganic additive.

Abstract: A method for measuring particle size distribution in a fluid material, involving inserting a laser beam instrument directly in the fluid flow line, wherein the laser beam instrument focuses a laser beam on a window directly coupled with the fluid flow line, wherein the fluid flow line comprises a fluid having a plurality of particles of different sizes, measuring a diameter of at least one particle in the fluid flow line by reflectance of the at least one particle as the at least one particle passes through the focused laser beam, and determining a duration of reflection of the at least one particle, and obtaining a count of particles in each of a pre-set range group of particle sizes, wherein the count of particles is used to determine particle size distribution in the fluid flow line.

Abstract: Methods and systems are provided for measuring a velocity of a droplet passing through a microfluidic channel.

Abstract: A system is described to facilitate the characterization of particles within a fluid contained in a vessel using an illumination system that directs source light through each vessel. One or more optical elements may be implemented to refract the source light and to illuminate the entire volume of the vessel. As the refracted source light passes through the vessel and interacts with particles suspended in the fluid, scattered light is produced and directed to an imager, while the refracted source light is diverted away from the imager to prevent the source light from drowning out the scattered light. The system can therefore advantageously utilize an imager with a large depth of field to accurately image the entire volume of fluid at the same time, facilitating the determination of the number and size of particles suspended in the fluid.

Abstract: This invention relates to a device for detecting an analyte in a sample comprising: a radiation source adapted to generate a series of pulses of electromagnetic radiation; a transducer having a pyroelectric or piezoelectric element and electrodes which is capable of transducing energy generated by non-radiative decay into an electrical signal; a detector which is capable of detecting the electrical signal generated by the transducer; a first reagent proximal to the transducer, the first reagent having a binding site which is capable of binding a labelled reagent proportionally to the concentration of the analyte in the sample, which labelled reagent being capable of absorbing the electromagnetic radiation generated by the radiation source to generate energy by non-radiative decay; a second reagent proximal to the transducer, the second reagent having a lower affinity for the labelled reagent under the conditions of the assay than the first reagent; and a third reagent proximal to the transducer, the third rea

Abstract: This invention relates to optical particle counters and methods capable of effectively distinguishing signals generated from particle light scattering from sources of noise. Embodiments of the invention, for example, use multisensory detector configurations for identifying and distinguishing signals corresponding to fluctuations in laser intensity from signals corresponding to particle light scattering for the detection and characterization of submicron particles. In an embodiment, for example, methods and systems of the invention compare signals from different detector elements of a detector array to identify and characterize noise events, such as noise generated from laser intensity instability, thereby allow for the detection and characterization of smaller particles. The system and methods of the present invention, thus, provide an effective means of reducing false positives caused by noise or interference while allowing for very sensitive particle detection.

Abstract: A fiber optic sensor to determine a property in an environment with a temperature exceeding 150 degrees Celsius includes a light source to emit broadband light, an etendue of the light source being less than 1000 square micro meter-steradians (?m2 sr), and an optical fiber to carry incident light based on the broadband light and a reflection resulting from the incident light. A photodetector detects a resultant light based on the reflection and outputs an electrical signal, and a processor processes the electrical signal from the photodetector to determine the property.

Abstract: A particle detecting apparatus has a condensing and growing unit to condense and grow a condensing component over particles contained in a gas while the gas imported through an inflow port is transported from a low temperature portion to a high temperature portion, a particle detector to detect a concentration of the particles contained in the gas discharged from an outflow port of the condensing and growing unit, a particle feeder to feed, to the inflow port of the condensing and growing unit, a test gas containing test particles whose particle diameter and the number of particles per unit volume are known, and a first determinator to determine whether a concentration of the test particles contained in the test gas detected by the particle detector has a predetermined value.

Abstract: A method for automated identification of a state of a sample such as, for example, for identifying whether or not the sample was centrifuged is presented. A device for analyzing samples and a laboratory automation system are also presented in which the method is applied.

Abstract: A method and system for separating multicomponent fluids into components having different buoyancies. A flow shaping member has a helical channel that imparts a helical motion to the fluid, and a separation chamber for separating the moving fluid into a helically moving heavier flow portion and a more buoyant portion along the central axis. A flow receiving member has a first collection horn with a mouth arranged to collect the higher buoyancy fluid and direct the fluid to an outlet. At least one other fluid passageway for carrying lower buoyancy fluid has an inlet surrounding of the collection horn, and directs the fluid to a separate outlet at an end of the separator. Additional collection horns can be arranged concentrically around the first collection horn to collect intermediate buoyancy flows. Cascaded fluid separators can concentrate the higher buoyancy fluid or the denser fluid.

Abstract: Embodiments herein include swept-source interferometric imaging systems employing arbitrary sweep patterns in which a swept-source is swept over a continuous spectral range where the variation of wavelength over time is noncontinuous. Embodiments include sweep patterns that result in reduction of signals from moving scatterers and where the sweep is synchronized with the dead time of the camera.

Abstract: An embodiment provides a method, including: operating a motor to position sample fluid within a fluid channel of a cuvette; transmitting light through an optical chamber of the cuvette; measuring a value of received light that has been transmitted through the optical chamber; comparing the measured value of light to one or more thresholds; determining a position of the sample fluid within the fluid channel based on a comparison from the comparing step; and generating a response based upon the position of the sample fluid with the fluid channel. Other aspects are described and claimed.

Abstract: Systems and methods for automatically determining a content item size may be based on a size of a viewport and a width of a parent element. A script may be configured to determine a size of a viewport, determine a width of a parent element of a resource, and determine a content item size based, at least in part, on the size of the view port and the width of the parent element. A dimension of the determined content item size may be used by a content item selection system to determine a set of content items. A content item selection system may select a content item from the determined set of content items and serve data to effect display of the selected content item in the parent element with the resource.

Abstract: A particle detecting device includes: a light measuring instrument that measures measured values for intensities of first, second, and third lights of mutually differing wavelengths, produced by particles to be measured; a boundary information storing portion that stores a non-linear discriminating boundary for separating a class of a first classification of particles and a class of a second classification of particles; and a particle classifying portion that classifies the particle being measured into either of the classifications for the first and second classifications of particles, based on measured values for the intensities of the first through third lights and on the discriminating boundary.

Abstract: A compressive imaging system includes an illumination system arranged to illuminate an object of interest with illumination light, and a detection system configured to detect at least a portion of the illumination light after being at least one of reflected from, scattered from, or transmitted through the object of interest or to detect fluorescent light from the object of interest and to provide an imaging signal. The compressive imaging system further includes an image processing system configured to communicate with the detection system to receive the imaging signal. The illumination light from the illumination system comprises a plurality of light pulses such that each light pulse has a preselected spectrum that is distinguishable from spectra of all other pulses. The image processing system is configured to form an image of the object of interest using information concerning the preselected spectra of the plurality of light pulses.

Abstract: Systems and methods are described that protect intellectual property rights in connection with 3-dimensional printing processes. In certain embodiments, an object a user would like to render with a 3-dimensional printing device may be compared with one or more managed objects having certain associated intellectual property rights. If the object is found to be similar to a managed object (e.g., similar in shape, function, composition, etc.), policy associated with the managed object may be enforced in connection with rendering the object. In this manner, intellectual property rights associated with the managed objects may be enforced.

Abstract: An optical sensing system for detecting objects passing through a volume of interest, wherein the sensing system has an emitter and a detector. The detector detects motion of object shadows generated as the object passes through the volume of interest between the emitter and detector. Motion detection algorithms, using computed motion vectors of the detected object, logically determine whether an object has traveled completely through the detection space, and can be used to discriminate a specific outcomes and/or impediments.

Abstract: A method and apparatus for measuring dissolved residue concentrations and particulate residue particle concentrations and size distribution in liquids, particularly colloidal suspensions. The method involves separating dissolved and particulate residues in liquids for subsequent analysis of the residue species. The method includes the steps of forming an aerosol from the liquid sample to be analyzed, evaporating the droplets in the aerosol to dryness, detecting and sizing the particles, and determining the liquid volumetric inspection rate. An apparatus for separating dissolved and particulate residues in liquids for determination of the concentrations of the two residue species as well as the size distribution of the particulate species is also disclosed. The apparatus includes a droplet former, a dryer communicatively connected to the droplet former, and a detector communicatively connected to the evaporator for detecting and sizing particles.

Abstract: A wavefront sensing technique using Polarization Rotation INTerferometry (PRINT) provides a self-referencing, high-resolution, direct measurement of the spatially dependent phase profile of a given optical beam. A self-referencing technique is used to create a reference beam in the orthogonal polarization and a polarization measurement to measure the spatial-dependent polarization parameters to directly determine the absolute phase profile of the beam under test. A high-resolution direct measurement of the spatially-resolved phase profile of one or more optical beams is realized.

Abstract: A surrogate challenge set including a plurality of containers containing a fluid, wherein at least one of the containers contains particulate matter; and reference probability-of-detection (POD) data for the at least one container containing the particulate matter is described. The fluid may be water containing at least about 0.5 wt % of a preservative, such as benzyl alcohol. The containers may be pharmaceutically acceptable containers such as vials, bottles, syringes, ampules and intravenous bags. The particulate matter may consist of a single particle having a particle size of at least about 50 ?m. A method of making the challenge set may include: disposing particulate matter in at least one of a plurality of containers comprising a fluid; generating probability-of-detection (POD) data for the plurality of containers; and including the probability-of-detection (POD) data in the challenge set. Methods of using the surrogate challenges sets are also provided.

Abstract: An optical sensing system for detecting objects passing through a volume of interest, wherein the sensing system has an emitter and a detector. The detector detects motion of object shadows generated as the object passes through the volume of interest between the emitter and detector. Motion detection algorithms, using computed motion vectors of the detected object, logically determine whether an object has traveled completely through the detection space, and can be used to discriminate a specific outcomes and/or impediments.

Abstract: Devices for detecting particle sizes and distributions using focused light scattering techniques, by passing a sample through a focused beam of light, are disclosed. In one embodiment, the devices include one or more lasers, whose light is focused into a narrow beam and into a flow cell, and dispersions are passed through the flow cell using hydrodynamic sample injection. In another embodiment, a plurality of lasers is used, optionally with hydrodynamic sample injection. Particles pass through and scatter the light. The scattered light is then detected using scatter and extinction detectors, and, optionally, fluorescence detectors, and the number and size of the particles is determined. Particles in the size range of 0.1 to 10 ?m can be measured. Using the device, significantly smaller particles can be detected than if techniques such as EQELS, flow cytometry, and other conventional devices for measuring biological particles.

Abstract: A microparticle sorting apparatus includes a detection unit which detects microparticles flowing through a flow path; an imaging device which images a droplet containing the microparticles which is discharged from an orifice provided on an edge portion of the flow path; a charge unit which applies a charge to the droplets; and a control unit which determines a delay time as from a time that the microparticles are detected by the detection unit to the time at which a number of bright spots in a standard region, which is set beforehand, of image information imaged by the imaging device reaches the maximum, making it possible for the charge unit to apply a charge to the microparticles once the delay time has lapsed after the microparticles are detected by the detection unit.

Abstract: A method and video sensor for precipitation microphysical features measurement based on particle image velocimetry. The CCD camera is placed facing towards the light source, which forms a three-dimensional sampling space. As the precipitation particles fall through the sampling space, double-exposure images of precipitation particles illuminated by pulse light source are recorded by CCD camera. Combined with the telecentric imaging system, the time between the two exposures are adaptive and can be adjusted according to the velocity of precipitation particles. The size and shape can be obtained by the images of particles; the fall velocity can be calculated by particle displacement in the double-exposure image and interval time; the drop size distribution and velocity distribution, precipitation intensity, and accumulated precipitation amount can be calculated by time integration.

Abstract: The particle size distribution measuring device 1 is so configured to calculate the particle size distribution with repeating several times a process to give the particle size distribution calculated by means of one iterative solver to the other iterative solver as an imaginary solution and to update the calculated particle size distribution as a new particle size distribution.

Abstract: A flow cytometer assembly includes a fluid controller configured to form a hydrodynamically focused flow stream including an outer sheath fluid and an inner core fluid. A coherent light source is configured to illuminate a particle in the inner core fluid. A detector is configured to detect a spatially coherent distribution of elastically scattered light from the particle excited by the coherent light source. An analyzing module configured to extract a three-dimensional morphology parameter of the particle from a spatially coherent distribution of the elastically scattered light.