By Particle Light Scattering Patents (Class 356/336)
  • Patent number: 11020058
    Abstract: A system for calculating blood pressure may include a sensor system and a control system. The control system may be capable of controlling one or more sensors of the sensor system to take at least two measurements, the at least two measurements including at least one measurement taken at each of two or more different measurement elevations of a subject's limb. In some examples, the control system may be capable of determining a blood flow difference based on the at least two measurements, of determining a hydrostatic pressure difference based on the two or more different elevations of the at least two measurements and of estimating a blood pressure based on one or more values of blood flow, the hydrostatic pressure difference and the blood flow difference.
    Type: Grant
    Filed: June 17, 2016
    Date of Patent: June 1, 2021
    Assignee: QUALCOMM Incorporated
    Inventors: Lars Lading, David Boettcher Baek
  • Patent number: 11009445
    Abstract: An in-fluid floating substance measurement flow cell includes: a main body having at least a predetermined portion made of a material having translucency; and a flow passage formed inside the main body, having both end openings at an outer surface of the main body in a substantially identical direction, and configured such that fluid flows in the flow passage. The flow passage has a predetermined section arranged between two opposing flat wall surfaces facing each other, and the predetermined portion includes the predetermined section.
    Type: Grant
    Filed: January 22, 2020
    Date of Patent: May 18, 2021
    Assignee: RION Co., Ltd.
    Inventors: Tomonobu Matsuda, Takashi Minakami, Daisuke Sakaue, Daisuke Shinozaki
  • Patent number: 10948625
    Abstract: A system, method, and device for determining volume concentration with diffraction of electromagnetic radiation. A device for determining a volume concentration of a fluid in a sample comprises a transducer, a transmitter, a detector, and a processor. The transducer generates a standing acoustic wave through the sample. The transmitter emits electromagnetic (EM) radiation into the sample such that the EM radiation is diffracted by the sample. The detector is responsive to the diffracted EM radiation and generates a signal indicative of a wavelength of an acoustic wave corresponding to the standing acoustic wave. The processor analyzes the signal to determine the volume concentration of the fluid in the sample.
    Type: Grant
    Filed: September 27, 2016
    Date of Patent: March 16, 2021
    Assignee: Halliburton Energy Services, Inc.
    Inventors: Satyan Gopal Bhongale, Wolfgang Hartmut Nitsche, John Laureto Maida, Michel Joseph LeBlanc
  • Patent number: 10895532
    Abstract: An airborne microorganism measurement device includes a housing including a first body and a second body, an air passage formed between the first body and the second body such that air containing airborne microorganisms pass therethrough, a charging part and a collecting part disposed in the air passage to charge and collect the airborne microorganisms, a high voltage generating device provided in the first body to supply a high voltage to the charging part and the collecting part, and a light emitting unit and a light receiving part provided in the second body to detect a fluorescent signal generated by irradiating the airborne microorganisms collected in the collecting unit with light.
    Type: Grant
    Filed: December 6, 2017
    Date of Patent: January 19, 2021
    Assignee: LG ELECTRONICS INC.
    Inventors: Sujin Lee, Bongjo Sung, Ilna Son, Sanggu Lee
  • Patent number: 10895500
    Abstract: An optical measurement method and system. The system includes, and method applies, a light source, a beamsplitter, at least one filter, a output photodetector for acquiring data of a sample, and a correction photodetector for correcting and maintaining output intensity from the light source. The filter is located between the light source and the correction photodetector for normalizing the spectrum of the input light being applied to input light correction. The filter may be incorporated into the beamsplitter and may be tuned to filter light from the light source for providing non-zero transmission of light with a near-zero gradient for wavelengths in a portion of the spectrum of the input light being applied to the sample and read by the output photodetector. The filter may also or alternatively be located downstream of the beamsplitter to correct for wavelength sensitivity of the correction photodetector.
    Type: Grant
    Filed: April 29, 2020
    Date of Patent: January 19, 2021
    Assignee: ALBERTA BIOPHOTONICS INC.
    Inventors: Elmar Prenner, Kirat Singh
  • Patent number: 10876948
    Abstract: A particle sensing device according to one embodiment comprises: a light-emitting unit for emitting light; a first flow path unit arranged under the light-emitting unit so as to be vertical to an optical shaft of the light-emitting unit, and through which air including particles flows; a light-receiving unit arranged at the optical shaft under the first flow path unit, and on which light that has passed through the first flow path is incident; and a light-absorbing unit arranged at the optical shaft under the light-receiving unit and absorbing light that has passed through the light-receiving unit.
    Type: Grant
    Filed: March 29, 2018
    Date of Patent: December 29, 2020
    Assignee: LG INNOTEK CO., LTD.
    Inventors: Jae Hyun Kim, Ji Hoon Kim
  • Patent number: 10866180
    Abstract: A particle diameter acquisition device includes an intensity distribution acquisition unit configured to acquire an intensity distribution of scattered light scattered from a multi-phase flow including dispersed phase at the time of irradiating the multi-phase flow with irradiation light, an attenuation gradient acquisition unit configured to acquire an attenuation gradient in the intensity distribution on the basis of the intensity distribution of the scattered light, a concentration acquisition unit configured to acquire a concentration of the dispersed phase in the multi-phase flow, a database configured to store intensity distribution data which is an intensity distribution of scattered light for each particle diameter and concentration of a dispersed phase, and a particle diameter acquisition unit configured to acquire a particle diameter of the dispersed phase on the basis of the acquired attenuation gradient, concentration, and intensity distribution data with reference to the intensity distribution da
    Type: Grant
    Filed: February 11, 2020
    Date of Patent: December 15, 2020
    Assignee: MITSUBISHI HEAVY INDUSTRIES, LTD.
    Inventors: Yoshiyuki Kondo, Yoshiteru Komuro, Atsushi Kodama, Koichi Tanimoto
  • Patent number: 10852187
    Abstract: The disclosure provides a Raman spectrum detection apparatus, including: a laser configured to emit laser light to an object to be detected; a Raman spectrometer configured to receive Raman light from the object; an imaging device configured to obtain an image of the object; and a controller configured to control an operation of the detection apparatus based on grayscales of the image. There is further provided a Raman spectrum detection method.
    Type: Grant
    Filed: December 19, 2018
    Date of Patent: December 1, 2020
    Assignee: Nuctech Company Limited
    Inventors: Haihui Liu, Hongqiu Wang, Jianhong Zhang, Jiaqian Zuo
  • Patent number: 10845287
    Abstract: Disclosed herein is a method of characterizing particles in a sample. The method comprises illuminating the sample in a sample cell with a light beam, so as to produce scattered light by the interaction of the light beam with the sample; obtaining a time series of measurements of the scattered light from a single detector; determining, from the time series of measurements from the single detector, which measurements were taken at times when a large particle was contributing to the scattered light; determining a particle size distribution, including correcting for light scattered by the large particle.
    Type: Grant
    Filed: May 17, 2019
    Date of Patent: November 24, 2020
    Assignee: Malvern Panalytical Limited
    Inventors: Jason Corbett, Alex Malm
  • Patent number: 10843526
    Abstract: An air-conditioning system of a motor vehicle may include a channel system configured to allow air to flow therethrough during operation and at least one heat exchanger positioned within the main channel and configured to air-condition air supplied to a motor vehicle interior of the motor vehicle. The channel system may include a main channel. The system may include a sensor device configured to measure an air characteristic of air to be analysed. The sensor device may include an analysis channel which the air to be analysed can flow through, a generation device configured to generate electromagnetic waves penetrating the analysis channel, a sensor temperature-control space separated from the analysis channel, and a temperature-control channel configured to apply air-conditioned air to the generation device to control a temperature of the generation device. The generation device is at least partially arranged in the sensor temperature-control space.
    Type: Grant
    Filed: September 3, 2018
    Date of Patent: November 24, 2020
    Assignee: Mahle International GmbH
    Inventors: Rainer Knoeller, Markus Michael, Anja Reiter, Walter Wolf
  • Patent number: 10837889
    Abstract: Apparatus (200) for measuring the particle-size distribution of a sample by light-scattering comprises a focusing optic (202) for producing a converging beam (203) generally along a propagation axis z. The apparatus comprises a mounting system which allows a dry sample cell (208A) and a wet sample cell (208B) to be mounted in the converging beam at different times and in respective planes which are mutually inclined so that in use of the apparatus respective positions (212, 214) at which transmitted light is focused for the two cells have a difference in displacement from the z axis that is less than for the case where the respective planes are substantially parallel. This allows use of a cheaper and less complex translation stage within the apparatus for mounting an optical detector for locating the two focus positions.
    Type: Grant
    Filed: September 11, 2012
    Date of Patent: November 17, 2020
    Assignee: Malvern Panalytical Limited
    Inventor: David Michael Spriggs
  • Patent number: 10835313
    Abstract: Systems and methods for performing RF ablation while monitoring the procedure using low coherence interferometry (LCI) data are described. A catheter includes a distal section, a proximal section, a multiplexer, and a sheath coupled between the distal section and the proximal section. The distal section includes one or more electrodes configured to apply RF energy to a portion of a sample in contact with the electrode. The distal section also includes a plurality of optical elements configured to transmit one or more beams of exposure radiation away from the distal section of the catheter. The proximal section includes an optical source configured to generate a source beam of radiation and a detector configured to generate depth-resolved optical data. The multiplexer is configured to generate the one or more beams of exposure radiation from the source beam of radiation.
    Type: Grant
    Filed: January 28, 2015
    Date of Patent: November 17, 2020
    Assignee: MEDLUMICS S.L.
    Inventors: Eduardo Margallo Balbás, José Luis Rubio Guivernau, Santiago Jiménez Valero, Alejandro Barriga Rivera, Justo Contreras Bermejo, Juan Lloret Soler
  • Patent number: 10795062
    Abstract: A system and method are provided for forming one-way light transmissive layers implementing optical light scattering techniques in those layers, and to objects, object portions, lenses, filters, screens and the like that are formed of, or that otherwise incorporate, such one-way light transmissive layers. Processes are provided by which to form, or otherwise incorporate, one or more one-way light transmissive, or substantially transparent, object portions or layers in solid or hollow objects Individual one-way light transmissive layers are formed of substantially-transparent sub-micrometer spheres, including micro-particles and/or nano-particles, with nano-voids incorporated between them.
    Type: Grant
    Filed: January 26, 2016
    Date of Patent: October 6, 2020
    Assignee: Face International Corporation
    Inventors: Clark D Boyd, Bradbury R Face, Jeffrey D Shepard
  • Patent number: 10764518
    Abstract: The present invention pertains to a pixel for use in a system for determining a distance to an object by range gating, said pixel comprising: a first charge storage well (221) and a second charge storage well (222) for accumulating electrical charges representative of amounts of light impinging on said pixel during respective sets of exposure intervals, wherein said first charge storage well (221) has a charge capacity that is at least 50% greater than a charge capacity of said second charge storage well (222). The invention also pertains to a range gating system comprising such a pixel.
    Type: Grant
    Filed: April 23, 2018
    Date of Patent: September 1, 2020
    Assignee: XENOMATIX NV
    Inventors: Dirk Van Dyck, Rik Paesen
  • Patent number: 10761008
    Abstract: A particle detecting device includes a chamber 30; a first introduction flow path 225 for introducing a particle-containing fluid into the chamber 30; a second introduction flow path 235 for introducing a particle-free fluid into the chamber 30; a light source 10 configured to illuminate fluid in the chamber 30 to detect particles contained in the fluid; a discharge flow path 260 for discharging fluid from the chamber 30; an introduction flow meter 245 configured to measure a flow rate of fluid flowing through the second introduction flow path 235; and a control unit 301 configured to perform control such that a fluid having a total flow rate obtained by adding a predetermined flow rate of fluid flowing through the first introduction flow path 225 to a flow rate of fluid flowing through the second introduction flow path 235, the flow rate being measured by the introduction flow meter 245, flows through the discharge flow path 260.
    Type: Grant
    Filed: May 23, 2017
    Date of Patent: September 1, 2020
    Assignee: AZBIL CORPORATION
    Inventor: Seiichiro Kinugasa
  • Patent number: 10753843
    Abstract: Provided is a gel particle measuring apparatus for detecting scattered light generated by light irradiation at a production start time point of a gel particle, and performing measurement promptly and accurately while suppressing attenuation of the scattered light in a solvent in which the phenomenon occurs.
    Type: Grant
    Filed: December 26, 2016
    Date of Patent: August 25, 2020
    Assignee: PROJECT KBF CO., LTD.
    Inventors: Toru Obata, Juichiro Ukon
  • Patent number: 10690694
    Abstract: A device (10) for determining a parameter of a fluid flow includes an elastically deformable boom (23, 28, 33, 42, 47), with an inflow area (29, 31, 32, 37, 38, 39, 40, 44, 45, 46, 49, 50) for fluid and a measurement apparatus (16) measuring deformation of the boom. A section of the inflow area is aligned askew and/or curved to a main fluid inflow direction (25). The boom has an inflow structure (24, 30, 34, 43, 48) on one free end. The inflow structure has the fluid inflow area. To determine the parameter of the fluid flow at high resolution, in particular a high angle resolution, the boom has a reflection surface (27) on a side facing away from the inflow structure and the measurement apparatus (16) has a laser (17). A beam axis (26) of the laser (17) is directed to the reflection surface (27) of the boom.
    Type: Grant
    Filed: January 12, 2016
    Date of Patent: June 23, 2020
    Assignee: CARL VON OSSIETZKY UNIVERSITÄT OLDENBURG
    Inventors: Joachim Peinke, Michael Hölling, Stephan Barth, Jaroslaw Puczylowski
  • Patent number: 10598603
    Abstract: Provided is an inspection lighting device with which, even when changes in light that occur at respective feature points on an object to be inspected are small, the amounts of those changes in light can be determined across the entire field-of-view range, and the feature points can be detected under exactly the same conditions. An inspection lighting device 100 includes a surface light source 1 and a lens 2 that is disposed between the surface light source 1 and an inspection object W, the lens 2 being disposed nearer to the inspection object W such that at least one of a shielding mask M1 and a filtering means F1 is located centered around a focal distance position of the lens. An irradiation solid angle of light emitted from the surface light source 1 and irradiated onto the inspection object W by the lens 2 is configured to have solid angle regions as desired, the solid angle regions having specific optical attributes.
    Type: Grant
    Filed: September 23, 2015
    Date of Patent: March 24, 2020
    Assignee: MACHINE VISION LIGHTING INC.
    Inventor: Shigeki Masumura
  • Patent number: 10571386
    Abstract: Light from a light source is directed at a flow path of particles of a flow cytometer. The directed light results in a light pattern having a plurality of lobes. A first signal is detected exceeding a first threshold. A second signal exceeding a second threshold is detected, wherein the second threshold is greater than the first threshold. Based on detecting the second trigger after detecting the first trigger, is determined that the first and second signals were created by a relatively large particle.
    Type: Grant
    Filed: October 23, 2017
    Date of Patent: February 25, 2020
    Assignee: Stratedigm, Inc.
    Inventors: Shervin Javadi, Arjuna Ragunath Karunaratne
  • Patent number: 10559072
    Abstract: An image detection device executing a detection process for images of a subject obtained by illuminating cyclically the subject with light having different spectral properties and capturing the subject at timings synchronizing with illuminating cycles of the light, the image detection device comprising a shift vector detection means that detects a shift vector of the subject based on a comparison result between an image of the subject captured at a current cycle and an image of the subject which is captured at a past cycle and is illuminated with the light having a same spectral property as that of the light illuminated at the current cycle.
    Type: Grant
    Filed: June 1, 2016
    Date of Patent: February 11, 2020
    Assignee: HOYA CORPORATION
    Inventor: Takao Makino
  • Patent number: 10539496
    Abstract: Devices for detecting particle sizes and distributions using focused light scattering techniques, by passing a sample through a focused beam of light, are disclosed. In one embodiment, the devices include one or more lasers, whose light is focused into a narrow beam and into a flow cell, and dispersions are passed through the flow cell using hydrodynamic sample injection. In another embodiment, a plurality of lasers is used, optionally with hydrodynamic sample injection. Particles pass through and scatter the light. The scattered light is then detected using scatter and extinction detectors, and, optionally, fluorescence detectors, and the number and size of the particles is determined. Particles in the size range of 0.1 to 10 ?m can be measured. Using the device, significantly smaller particles can be detected than if techniques such as EQELS, flow cytometry, and other conventional devices for measuring biological particles.
    Type: Grant
    Filed: August 23, 2016
    Date of Patent: January 21, 2020
    Assignee: Invitrox, Inc.
    Inventor: Don Gabriel
  • Patent number: 10539490
    Abstract: An apparatus of ultrafast particle dynamics measurement based on photon ensemble correlation spectroscopy include steps of: dispersing a particle sample to be detected; establishing a plurality of sampling volumes, and collecting dynamic scattered light signals in parallel; and constructing sample ensembles based on scattered signals of the sampling volumes, analyzing time correlations between the sample ensembles, and detecting particle dynamic characteristics. A period for a single measurement of particles according to the method can be in the range of several milliseconds to several tens of milliseconds, which is conducive to real-time detection. More accurate and reliable correlation characterization can be obtained by combining the detected complex-valued scattered signals with both amplitude and phase information. Furthermore, the particle detection is able to be spatially resolved, so as to achieve spatially resolved particle dynamic characteristics.
    Type: Grant
    Filed: February 8, 2017
    Date of Patent: January 21, 2020
    Assignee: ZHEJIANG UNIVERSITY
    Inventors: Peng Li, Pei Li
  • Patent number: 10527543
    Abstract: The technology disclosed in this application provide for non-destructive and non-contact optical characterization of fiber reinforced plastic composites and other structures under test based on optical transmission scanning.
    Type: Grant
    Filed: February 26, 2018
    Date of Patent: January 7, 2020
    Assignee: General Photonics Corporation
    Inventors: Anton Khomenko, Xiaotian Steve Yao, Oleksii Karpenko, Xiaojun James Chen
  • Patent number: 10520412
    Abstract: Disclosed herein is a method of characterizing particles in a sample. The method comprises illuminating the sample in a sample cell with a light beam, so as to produce scattered light by the interaction of the light beam with the sample; obtaining a time series of measurements of the scattered light from a single detector; determining, from the time series of measurements from the single detector, which measurements were taken at times when a large particle was contributing to the scattered light; determining a particle size distribution, including correcting for light scattered by the large particle.
    Type: Grant
    Filed: February 4, 2019
    Date of Patent: December 31, 2019
    Assignee: Malvern Panalytical Limited
    Inventors: Jason Corbett, Alex Malm
  • Patent number: 10495562
    Abstract: In flow cytometry, particles (2) can be distinguished between populations (8) by combining n-dimensional parameter data, which may be derived from signal data from a particle, to mathematically achieve numerical results representative of an alteration (48). An alteration may include a rotational alteration, a scaled alteration, or perhaps even a translational alteration. Alterations may enhance separation of data points which may provide real-time classification (49) of signal data corresponding to individual particles into one of at least two populations.
    Type: Grant
    Filed: December 1, 2017
    Date of Patent: December 3, 2019
    Assignee: Beckman Coulter, Inc.
    Inventors: George C. Malachowski, Paul Barclay Purcell, Edward Allan Stanton, Kenneth Michael Evans
  • Patent number: 10488313
    Abstract: A particle mass concentration in an aerosol volume can be detected by an optical particle sensor. In order to ensure that different degrees of contamination of the optical particle sensor can be detected by the sensor and can be taken into consideration, the optical particle sensor identifies individual particles at low particle concentrations of up to 1000 particle s/cm3.
    Type: Grant
    Filed: February 5, 2018
    Date of Patent: November 26, 2019
    Assignee: PARAGON AG
    Inventor: Ralf Moenkemoeller
  • Patent number: 10481004
    Abstract: A light wavelength measurement method of measuring a wavelength of target light includes: receiving target light on a second dispersion device that disperses the target light into a plurality of second beams which reach a plurality of positions corresponding to the wavelength of the target light; and measuring the wavelength of the target light, by using the plurality of the second beams as a vernier scale for measuring the wavelength of the target light within a wavelength range specified by a main scale.
    Type: Grant
    Filed: November 14, 2017
    Date of Patent: November 19, 2019
    Assignee: OSAKA UNIVERSITY
    Inventors: Tsuyoshi Konishi, Takema Satoh, Tomotaka Nagashima
  • Patent number: 10458896
    Abstract: The present invention relates to methods and systems for image cytometry analysis, typically at low optical magnification, where analysis is based on detection of biological particles using UV bright field, dark field or one or more sources of excitation light. The system comprises illumination means (11, 112), a sample holder (100), a sample compartment (101), imaging means (120), collection means (121), light modulation means (122, 123), and detection means (130) with active detection elements (131).
    Type: Grant
    Filed: May 28, 2014
    Date of Patent: October 29, 2019
    Assignee: ChemoMetec A/S
    Inventors: Martin Glensbjerg, Johan Holm, Søren Kjaerulff, Frans Ejner Ravn Hansen
  • Patent number: 10379114
    Abstract: A method for determining a radius of elements suspended in a medium includes binding the elements to nanoparticles to form bound element-nanoparticle aggregates, superposing first and second Doppler-shifted optical waves having a variable frequency shift between them in the medium such that there is a gain in energy of the first optical wave with respect to the second optical wave, varying the frequency shift and measuring the gain while varying the frequency shift to determine the value of the frequency shift at which there is a peak in the gain, determining the radius of the bound element-nanoparticle aggregates based on the value of the frequency shift at which there is a peak in the gain, and determining the radius of the elements based on the radius of the bound element-nanoparticle aggregates.
    Type: Grant
    Filed: October 10, 2017
    Date of Patent: August 13, 2019
    Assignee: Solaris Nanosciences, Inc.
    Inventor: Nabil Lawandy
  • Patent number: 10368775
    Abstract: Systems and methods for evaluating neuromodulation via hemodynamic responses are disclosed herein. A system configured in accordance with embodiments of the present technology can include, for example, a neuromodulation catheter comprising an elongated shaft having a distal portion, and a plurality of electrodes spaced along a distal portion. The system can further include a controller communicatively coupled to the electrodes. The controller can be configured to apply first and second stimuli at and/or proximate to a target site within a blood vessel before and after delivering neuromodulation energy to the target site, and detect, via at least one of the electrodes, vessel impedance resulting from the first and second stimuli to determine a baseline impedance and a post-neuromodulation impedance. The controller can further be configured to assess the efficacy of the neuromodulation based, at least in part, on a comparison of the baseline impedance and the post-neuromodulation impedance.
    Type: Grant
    Filed: October 1, 2015
    Date of Patent: August 6, 2019
    Assignee: Medtronic Ardian Luxembourg S.a.r.l.
    Inventors: Douglas A. Hettrick, Avram Scheiner
  • Patent number: 10369776
    Abstract: An additive manufacturing system that retains a print head for printing a three-dimensional part in a layer-by-layer manner using an additive manufacturing technique, where the retained print head is configured to receive a consumable material, melt the consumable material, and extrude the molten material. The system also includes a velocimetry assembly configured to determine flow rates of the molten material, and a controller assembly configured to manage the extrusion of the molten material from the print head, and to receive signals from the velocimetry assembly relating to the determined flow rates.
    Type: Grant
    Filed: December 21, 2016
    Date of Patent: August 6, 2019
    Assignee: STRATASYS, INC.
    Inventor: J. Samuel Batchelder
  • Patent number: 10365197
    Abstract: An optical particle sensor has at least first and second threshold settings applied to an optical sensor or a sensor signal to obtain first and second optical sensor readings. The first and second optical sensor readings are processed to determine a parameter which is dependent on a type of pollution event. The parameter is used to determine from at least one of the first and second optical sensor readings a mass of all particles below a first particle size. In this way the mass of all particles below a desired size can be evaluated, even though the optical sensor may not be responsive to the smallest particles.
    Type: Grant
    Filed: June 6, 2016
    Date of Patent: July 30, 2019
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Michiel Johannes Jongerius, Gerben Kooijman, Koray Karakaya, Okke Ouweltjes
  • Patent number: 10359350
    Abstract: Disclosed herein is a novel optical particle characterization system and method of use that can be applied to harsh environments. By separating the sensing components from the electronics unit and using optical fibers for interconnection, only the sensing components need to endure harsh environmental conditions. This reduces the design constraints on the electronics unit and permits the incorporation of optical components into the sensing probe that can withstand high-temperature and high-pressure environments.
    Type: Grant
    Filed: January 23, 2018
    Date of Patent: July 23, 2019
    Inventors: Hai Lin, Gregor Arthur Waldherr
  • Patent number: 10267722
    Abstract: A flow cytometry system including a measuring chamber, an injection device arranged to inject a flow of biological particles to be analyzed in the measuring chamber, an evacuation device arranged to evacuate outside of the cytometry system the flow of biological particles injected in the measuring chamber, a measuring set arranged to measure at least one optical property of the biological particles to be analyzed, the measuring set including an emission device arranged to emit a light beam in the direction of the measuring chamber and capable of crossing the flow of biological particles, and at least one collecting device arranged to collect light rays coming from the measuring chamber, where the flow cytometry system further includes a support on which the injection device, the evacuation device, the emission device and the at least one collecting device are mounted.
    Type: Grant
    Filed: June 23, 2015
    Date of Patent: April 23, 2019
    Assignee: ARTEION
    Inventor: Alain Rousseau
  • Patent number: 10264237
    Abstract: As to N images captured at different focus positions, which are arrayed in order of focus positions, N/2 images are set as feature point extraction images so that at least one of two adjacent images becomes a feature point extraction image; corresponding points corresponding to a feature point, extracted from the feature point extraction image, are searched for from the other images; a correction parameter, with which corresponding positions of the N images are matched, is calculated from a positional relation of the feature point and the corresponding points; and, with an image whose view angle is the smallest among the N images as a reference, the other images are corrected.
    Type: Grant
    Filed: November 4, 2014
    Date of Patent: April 16, 2019
    Assignee: SHARP KABUSHIKI KAISHA
    Inventors: Keisuke Omori, Kei Tokui
  • Patent number: 10210643
    Abstract: An image processing apparatus generates an image from a captured image, in which an influence of fine particles in an atmosphere has been reduced. The image processing apparatus acquires the captured image, performs correction processing (i) to correct the captured image to reduce the influence of fine particles in the atmosphere, based on a pixel value of a pixel in which a scattered light component is enhanced due to the fine particles, and (ii) to generate a corrected captured image, and outputs an image based on the corrected captured image. The pixel value of the pixel, in which the scattered light component is enhanced due to the fine particles, is determined based on a lower pixel value, except for a minimum pixel value, within a predetermined block that includes the pixel in the captured image.
    Type: Grant
    Filed: January 12, 2017
    Date of Patent: February 19, 2019
    Assignee: Canon Kabushiki Kaisha
    Inventor: Yasuhiro Itoh
  • Patent number: 10197485
    Abstract: Disclosed herein is a method of characterizing particles in a sample. The method comprises illuminating the sample in a sample cell with a light beam, so as to produce scattered light by the interaction of the light beam with the sample; obtaining a time series of measurements of the scattered light from a single detector; determining, from the time series of measurements from the single detector, which measurements were taken at times when a large particle was contributing to the scattered light; determining a particle size distribution, including correcting for light scattered by the large particle.
    Type: Grant
    Filed: September 9, 2016
    Date of Patent: February 5, 2019
    Assignee: MALVERN PANALYTICAL LIMITED
    Inventors: Jason Corbett, Alex Malm
  • Patent number: 10184144
    Abstract: A method for identification and/or characterization of a microbial agent present in a sample includes a step of analytical test data (e.g., obtaining intrinsic fluorescence values over a range of emission wavelengths) from the microbial agent. The analytical test data is transformed thereby minimizing strain to strain variations within an organism group. With the aid of a programmed computer, a multi-level classification algorithm coded as a set of processing instructions operates on the transformed analytic test data. The multiple levels correspond to different levels in a taxonomic hierarchy for microbial agents suspected of being in the sample.
    Type: Grant
    Filed: January 16, 2014
    Date of Patent: January 22, 2019
    Assignee: bioMerieux, Inc.
    Inventors: Michael Ullery, Erin Mathias, Jones M. Hyman, John D. Walsh
  • Patent number: 10145776
    Abstract: A system for analyzing fluid includes a housing having first and second opposing surfaces spaced to form a fluid chamber, a light source disposed to direct light at the first surface of the housing; and a digital imaging circuit disposed to detect light at the second surface of the housing. The digital imaging circuit includes a pixel array configured to capture one or more digital images of an illuminated fluid. The system also includes a processor configured to: capture multiple digital images of the fluid at different camera exposure levels, calculate a net radiant energy value at a plurality of different integration times within at least two images, calculate a slope of the net radiant energy value with respect to integration time in a selected image, and determine size distribution and volume fraction of particles within the fluid based on the calculated slope.
    Type: Grant
    Filed: April 12, 2016
    Date of Patent: December 4, 2018
    Assignee: Massachusetts Institute of Technology
    Inventors: Pranay Jain, Sanjay E. Sarma
  • Patent number: 10132716
    Abstract: The present invention discloses a method for measuring a mode field diameter (MFD) of a single-mode fiber using an optical integration technique employing a gradually variable aperture. The method transforms, according to Petermann II definition, an integral operation in a formula of an MFD of a single-mode fiber into elementary arithmetic operations to be performed on a mean square value of the numerical aperture of the fiber. By using an optical integrator having a gradually variable aperture, the mean square value of the numerical aperture of the single-mode fiber can be precisely measured by one of the following three methods: translation, rotation and beam splitting, thus accordingly solving the MFD of the test fiber. The aforementioned measurement an MFD of a single-mode fiber is characterized by precision, high speed and convenience, and can be widely applied in various applications, such as measurement standards, automated test equipment, and engineering instruments.
    Type: Grant
    Filed: June 3, 2018
    Date of Patent: November 20, 2018
    Inventors: Jin Zhou, Wenjun Zhou
  • Patent number: 10113945
    Abstract: The present invention comprises methods and apparatus for measuring light scattering from particles and images of particles, and for combining size distributions from the measurements to produce a single size distribution over a larger size range.
    Type: Grant
    Filed: February 19, 2018
    Date of Patent: October 30, 2018
    Assignee: MICROTRAC INC.
    Inventor: Michael Trainer
  • Patent number: 10101258
    Abstract: A novel filter effectiveness detection method for AMCs (Airborne Molecular Contaminations) is provided herein, which is on-line, economical and applicable for diverse AMCs, using gas-to-particle conversion with soft X-ray irradiation radiation. In one embodiment, this method was conducted through AMC filter evaluations comparing two granular activated carbons (GACs), which are widely used AMC filter media, challenged with sulfur dioxide (SO2), which is one of the major known AMCs in cleanrooms. Using this method, the concentration of gaseous SO2 was assessed in terms of particle volume concentrations after the gas-to-particle conversion assisted by the soft X-ray irradiation. The results of this detection method showed high sensitivity to SO2, down to parts per trillion-levels, which are levels that are too low to be detectable by currently available commercial gas sensors.
    Type: Grant
    Filed: August 27, 2015
    Date of Patent: October 16, 2018
    Assignee: TSI, Incorporated
    Inventors: Stanley L. Kaufman, David Y. H. Pui, Chang Hyuk Kim
  • Patent number: 10054529
    Abstract: An irradiation optical system 12 irradiates a fluid flowing in a flow passage 2a with one light among a plurality of lights obtained by branching light from a light source 1 and forms the detection area. A detection optical system 13 makes scattered light with a different direction from an optical axis of the irradiation optical system enter a beam splitter 17 among the scattered lights from particles contained in the fluid in this detection area. Meanwhile, a beam expander 16 makes another light among the plurality of lights enter the beam splitter 17 as reference light. A detector 4 receives an interference light, by the scattered light and the reference light, obtained by the beam splitter 17 by light receiving elements and generates a detection signal corresponding to the interference light. A counting unit 6 counts the particles based on this detection signal.
    Type: Grant
    Filed: March 4, 2016
    Date of Patent: August 21, 2018
    Assignee: RION Co., Ltd.
    Inventors: Tomonobu Matsuda, Masaki Shimmura, Yuki Yamakawa
  • Patent number: 10054532
    Abstract: This invention provides methods and devices to measure particle suspension concentrations in the presence of potential interferents. Particle back-scatter readings are taken at light wavelengths that are absorbed by the medium before interacting with surrounding objects. Source-detector spacings are minimized compared to the mean absorbance path length of light, thereby maximizing the range of sensitivity to particle concentration. Discrimination against potentially interfering particles, such as bubbles, is provided by mapping the signal distribution against the central signal value and/or by the use of statistical measures with reduced dependence on outliers. The methods and devices allow accurate particle concentration readings over a wide range of concentration in environments crowded with potentially interfering objects and in the presence of variable concentrations and sizes of potentially interfering particles.
    Type: Grant
    Filed: August 17, 2017
    Date of Patent: August 21, 2018
    Inventors: Martin P. Debreczeny, Joseph A. Christman, Gerald P. Coleman
  • Patent number: 10036698
    Abstract: An image flow cytometer for observing a microparticulate sample includes a flow chamber having a flow channel that permits the microparticulate sample to travel in a flow direction. An irradiation system scans an irradiation spot across a sensing area of the flow channel in a scan direction different from the flow direction. A detection system detects resultant light from the sensing area and provides a detection signal. An alignment system alters a location of the sensing area with respect to the flow chamber. A control unit causes the irradiation system to scan the irradiation spot during a first measurement interval and operates the alignment system to translate the location of the sensing area along the flow direction. The flow chamber can be mounted to a movable stage in some examples, and the alignment system can move the flow chamber substantially opposite the flow direction using the stage.
    Type: Grant
    Filed: June 20, 2016
    Date of Patent: July 31, 2018
    Assignee: CAPTL LLC
    Inventors: Masanobu Yamamoto, J. Paul Robinson
  • Patent number: 10018549
    Abstract: Devices and methods are described for measuring formed blood component sedimentation rate. Some of the methods may use (1) centrifugal techniques for separating red blood cells from plasma and (2) video and/or still imaging capability. Both may be used alone or in combination to accelerate formed blood component sedimentation and to measure its rate. In one example, the method may advantageously enable rapid measurement of sedimentation rate using small blood sample volumes. Automated image analysis can be used to determine both sedimentation rate and hematocrit. Automated techniques may be used to compensate for effects of hematocrit on uncorrected sedimentation rate data.
    Type: Grant
    Filed: April 19, 2016
    Date of Patent: July 10, 2018
    Assignee: Theranos IP Company, LLC
    Inventors: Mark Dayel, Samartha Anekal, Elizabeth A. Holmes
  • Patent number: 9964495
    Abstract: Near-field spray characteristics are established from local measurements which are acquired by data acquisition sub-system capable of complete scanning of the area (volume) of interest in the spray which uses different laser-based probes (shadowgraphy, PIV, diffraction) to obtain drops related measurements. A mechanical patternator measures volume flux distribution of the spray under study. The measurement data are post-processed to obtain spatially-resolved spray characteristics which are mapped in a spherical coordinate system consistent with the kinematics of the spray. A data compression scheme is used to generate compact analytical functions describing the nozzle spray based on the measurement data. These analytical functions may be useful for initiating the nozzle spray in computational fluid dynamics (CFD) based spray dispersion and fire suppression modeling.
    Type: Grant
    Filed: November 4, 2013
    Date of Patent: May 8, 2018
    Assignee: University of Maryland
    Inventors: Andre W. Marshall, Ning Ren
  • Patent number: 9937895
    Abstract: A vehicle disabling apparatus for remotely disabling a vehicle having an engine comprises a source (4) of high frequency energy for generating a high frequency signal and a modulator (1) for modulating the high frequency signal by applying an effects signals package. The effects signal package comprises a plurality of respective effects signals and each effects signal comprises a pulse train, the effects signals package being non-vehicle specific. An antenna (6) directs the effects signal package modulated signal at a remote vehicle to disrupt the vehicle engine by affecting the target vehicle engine management system.
    Type: Grant
    Filed: March 9, 2015
    Date of Patent: April 10, 2018
    Assignee: E2V TECHNOLOGIES (UK) LIMITED
    Inventors: Gary Stimson, Stuart Guy, Matthew Hicks
  • Patent number: 9927343
    Abstract: An apparatus for detecting a size of particles in a spray jet includes a substantially square frame. A first emitter unit and a first detection unit, and a second emitter unit and a second detection unit, are respectively provided at opposite corners of the frame. Two light beams that cross each other in a focus are generated by the respective emitter units. Passage of a particle through the focus is detected based on light intensity signals from the first and second detection units. Using another set of light beams that cross each other and that are separated from the above-noted light beams in the direction of flight of the particle, passage of the particle through a second common focus can be detected. Particle velocity and particle size can be obtained based on the time difference between the passage of the particle through the two foci.
    Type: Grant
    Filed: June 10, 2016
    Date of Patent: March 27, 2018
    Assignee: SENSOR INSTRUMENTS ENTWICKLUNGS—UND VERTRIEBS GMBH
    Inventor: Walter Braumandl
  • Patent number: 9921144
    Abstract: Devices and methods for detecting particulate matter are described herein. One device includes a laser, a reflector, an ellipsoidal reflector, and a detector, wherein the laser is configured to emit a beam, the reflector is configured to reflect the beam toward the ellipsoidal reflector, and the ellipsoidal reflector has a first focal region located on a path of the reflected beam, and a second focal region located at a surface of the detector.
    Type: Grant
    Filed: June 29, 2016
    Date of Patent: March 20, 2018
    Assignee: Honeywell International Inc.
    Inventors: Barrett E. Cole, Robert P. Costello