Abstract: A particle size distribution measuring apparatus having: a light intensity distribution obtaining unit for obtaining the light intensity distribution that occurs when the sample cell is irradiated with light for measurement from a light source through detection by a detector; and a particle size distribution calculating unit for calculating the particle size distribution of the particles to be measured included in the sample by using the light intensity distribution obtained by the light intensity distribution obtaining unit, the temperature adjusting member for adjusting the temperature of the sample cell is movable between a first location along the light path around the sample cell and a second location that is outside the light path, and the temperature adjusting member is moved to the second location when the sample is irradiated with the light for measurement from the light source.

Abstract: An optical interrogation system, e.g., an OFDR-based system, measures local changes of index of refraction of a medium contained within a light guiding tube and includes an optical interferometric interrogator, optical detection circuitry, and a data processor. The data processor initiates a sweep of the light source and guide light from an interrogating light source into a medium contained by a tube which restricts movement of particles provided into the tube, where the medium is subjected to a driving force that overcomes resistance to movement of particles through the medium in the tube. The optical interferometric interrogator provides an optical interference pattern associated with a group of particles having moved in the tube as a result of the driving force. Based on the optical interference pattern, the data processor identifies a current location of the group of particles in the tube.

Abstract: There is provided a microparticle analysis apparatus including a light detection unit configured to detect forward-scattered light generated from a microparticle that is an analysis target. The light detection unit includes a circuit having a high-pass filter that removes low frequency noise included in light entering the light detection unit and switches to the high-pass filter according to a predetermined frequency of the forward-scattered light.

Abstract: Flow cytometer systems are provided having intermediate angle scatter detection capability. In some aspects, systems are provided that include an intermediate angle scatter (IAS) light detector positioned to measure intermediate angle scatter emitted from a flow cytometer. The system further includes a mask disposed across a portion of the IAS light detector and positioned between the flow cell and the IAS light detector to cover at least a central portion of the IAS light detector so as to block a diffraction pattern observed at the detector. In some instances, the diffraction pattern is created by a flat beam profile irradiating the sample. Methods are also provided for configuring a flow cytometer to block a diffraction pattern created by (1) a flat laser beam profile irradiating a flow cytometer liquid sample, or (2) a mismatched index of refraction between a sheath fluid and a liquid sample in a flow cytometer.

Abstract: An airborne, gas, or liquid particle sensor with a mixed-mode photo-amplifier front-end. The photo-amplifier uses pulse-height for the high-gain channel and integrates the pulse-energy for the low-gain channel to provide for a larger dynamic range for larger size particles.

Abstract: In order to solve the problem in that, when a fundus is irradiated with multiple beams, a load has been placed on a subject, an imaging apparatus for imaging an object to be inspected based on return light from a first area in the object to be inspected, which is irradiated with first light, including: a determination unit for determining a second area being narrower than the first area in the object to be inspected; and a control unit for restricting the irradiation with the first light in the second area, which is irradiated with second light.

Abstract: An apparatus for analyzing biologic fluid is provided that includes a first planar member, a second planar member, and at least three separators. At least one of planar members is transparent. The separators are disposed between the members, and separate the members to form a chamber having a height. At least one of the members or separators is sufficiently flexible to permit the chamber height to approximate the mean size of the separators. During use, the biologic fluid to be analyzed is disposed within the chamber.

Abstract: There is disclosed improved apparatus and methods for detection of shape, size and intrinsic fluorescence properties of a fluid borne particle wherein the apparatus comprises a laser, two light sources, two detectors, and optionally a third detector. The apparatus is particularly suitable for detection of airborne biological particles.

Abstract: Apparatus are described for measuring the characteristics of colloidal particles suspended in transparent media by Dynamic Light Scattering (DLS) and Depolarized Dynamic Light Scattering (DDLS) into regions where conventional measurements are difficult or impractical. Matching the diameter of an illuminating beam and an intersecting diameter of a field stop image extends measurements into regions that include concentrated turbid suspensions that frequently appear so visually opaque that multiple scattering typically gives a falsely low estimate of particle size.

Abstract: The present invention relates to a logging tool for detecting an element present in a fluid surrounding the tool downhole. The element is at least one bubble, particle or debris in the fluid, and the tool has a longitudinal axis and comprising an emitting device for emitting radiation, a lens for transmitting the radiation in a predetermined pattern of radiation, and a receiving device.

Abstract: Apparatus (200) for measuring the particle-size distribution of a sample by light-scattering comprises a focusing optic (202) for producing a converging beam (203) generally along a propagation axis z. The apparatus comprises a mounting system which allows a dry sample cell (208A) and a wet sample cell (208B) to be mounted in the converging beam at different times and in respective planes which are mutually inclined so that in use of the apparatus respective positions (212, 214) at which transmitted light is focused for the two cells have a difference in displacement from the z axis that is less than for the case where the respective planes are substantially parallel. This allows use of a cheaper and less complex translation stage within the apparatus for mounting an optical detector for locating the two focus positions.

Abstract: Apparatus (100) for measuring particle size distribution by light scattering comprises a blue LED (102) and a 633 nm helium neon laser (104). Light output from the LED and laser is separately passed or reflected by a dichroic element (116) onto a common path through a sample cell (122) containing a sample, the particle size distribution of which is to be measured. Light scattered from the sample cell is detected by one or more detectors (112B-H). Light transmitted by the sample cell is detected by detectors 112A, 112J. Output signals from one or more of the detectors are passed to a computation unit (114) which calculates particle size distribution. A small percentage of light from the blue LED is reflected by the dichroic element to a detector (110). Similarly, a small percentage of light from the laser is passed by the dichroic element to the detector. Output signals from the detector are fed back to control units (106, 108) to stabilise the output power of the LED and laser.

Abstract: A method of using LIDAR on an airborne vehicle is described. A beam of radiation is transmitted to target areas at least one of above, below, and in front of the airborne vehicle, the target areas including particles or objects. Scattered radiation is received from the target areas. Respective characteristics of the scattered radiation are determined. An air turbulence factor or characteristics are determined from the respective characteristics. The airborne vehicle is controlled based on the air turbulence factor, such that turbulence experienced by the airborne vehicle is minimized. Alternatively, the airborne vehicle is controlled based on the characteristics to avoid colliding with the one or more objects. In another example, the airborne vehicle is controlled based on the characteristics to reduce headwind or increase tailwind, and substantially reduce a carbon footprint of the aircraft.

Abstract: The invention relates to a flow cytometer system and method to apply a gain to data measurements to improve the display of the data measurements. The method for applying a gain to data detected in a flow cytometer, involves obtaining measurements from a detector in a flow cytometer, applying a gain to the measurements to produce shifted measurements to allow for improved display of the shifted measurements while maintaining the relationship between data points of the shifted measurements and displaying the shifted measurements on a display.

Abstract: Apparatus for determining particle-size distribution of a sample by light-scattering includes a helium neon laser (102), a sample cell having cell windows (120, 122) and a focal plane detector (124). Detectors are also provided for detecting light scattered by a sample within or flowing through the sample cell. The apparatus includes a first (114) and second (116) folding mirrors arranged to fold the optical path from the laser to the sample cell so that the laser is vertically below the sample cell. The folding mirrors are mounted within a dust-proof housing (104), the entrance (106) and exit (108) components thereof being other optical components generally used within light- scattering apparatus. The entrance component is mounted such that its outward normal points downwards and the exit component is mounted substantially vertically so that these components do not accumulate dust.

Abstract: A flow cytometer assembly includes a fluid controller configured to form a hydrodynamically focused flow stream including an outer sheath fluid and an inner core fluid. A coherent light source is configured to illuminate a particle in the inner core fluid. A detector is configured to detect a spatially coherent distribution of elastically scattered light from the particle excited by the coherent light source. An analyzing module configured to extract a three-dimensional morphology parameter of the particle from a spatially coherent distribution of the elastically scattered light.

Abstract: A method of detecting a concentration of a target component by using a reference wavelength includes: defining a wavelength at which a light intensity is insensitive to the variation of the target component concentration as a reference wavelength for the target component; detecting spectra at both the reference wavelength and a further measuring wavelength; processing the spectrum detected at the further measuring wavelength, with the spectrum detected at the reference wavelength as an inner reference, to obtain a characteristic spectrum including specific information of the target component; building a calibration model between the characteristic spectrum and the concentration of the target component; and determining the concentration of the target component based on the calibration model.

Abstract: Disclosed is a fine particle measurement apparatus including a light condensing unit that condenses irradiated light irradiated to a sample flow where fine particles pass through and directly propagates the light without scattering, and scattered light scattered by the fine particles to an optical receiver divided into a plurality of regions; a position controller that controls the relative positions of members of an optical path; and a control unit that detects positions of condensing spots of the irradiated light and the scattered light based on signal intensities of each region of the optical receiver, and controls the position controller such that the positions of the condensing spots of the irradiated light and the scattered light match with each other.

Abstract: A method and a particle analyzer are provided for determining a particle size distribution of a liquid sample including particles of a lower size range, particles of an intermediate size range, and particles of an upper size range. A dark-field image frame is captured in which the particles of the lower size range and the particles of the intermediate size range are resolved, and a bright-field image frame is captured in which the particles of the intermediate size range and the particles of the upper size range are resolved. Absolute sizes of the particles of the intermediate size range and the particles of the upper size range are determined from the bright-field image frame. Calibrated sizes of the particles of the lower size range are determined from the dark-field image frame by using the particles of the intermediate size range as internal calibration standards.

Abstract: A method and apparatus for the illumination of a sample are disclosed. An imaging illumination light source is directed to pass through an absorbing/transmitting structure in order to illuminate the sample and any containing vessel. A diffuser may aid in properly dispersing the light from the imaging illumination source. A light sensitive detector such as a camera records an image therefrom. The beam from a light scattering source is directed through the sample and any containing vessel, and upon exiting the sample/vessel, impinges upon the absorbing/transmitting structure selected to absorb at the wavelength of the light scattering source. Scattered light from the sample is collected by a photo detector. Methods of use for the novel lighting system are also disclosed.

Abstract: A method for distinguishing and sorting cells characterized by comprising distinguishing and sorting a specific cell mass or a part of the cells in the cell mass with the use of transmitted light data reflecting the morphological characteristics of the cells such as size and shape optionally together with side-scattering light data reflecting the characteristics of the internal structure of the cells. The part of the cells in the specific cell mass as described above are at the G1 stage or at a part of the M stage in the cell cycle. A part of the cells at the G1 stage are referred to as the left bottom line in an analytical dispersion diagram of the cells wherein the abscissa indicates the transmitted light data, while a part of the cells at the M stage are referred to as the right bottom line in the analytical dispersion diagram of the cells wherein the abscissa indicates the transmitted light data.

Abstract: There is provided a microparticle measurement apparatus including a first light source configured to irradiate excitation light on a droplet containing a microparticle, the droplet being discharged from an orifice, a second light source configured to irradiate illumination light on the droplet for acquiring an image of the droplet, a light receiving element configured to detect fluorescence generated from the microparticle due to the irradiation of the excitation light, and to acquire an image of the droplet, and a filter member configured to be arranged between the droplet and the light receiving element. The filter member includes a first area through which the fluorescence and the illumination light pass, and a second area that is provided around the first area and that has a wavelength selectivity which lets the fluorescence pass through but blocks the illumination light.

Abstract: An aerosol generation system has a light source arrangement which provides signals at first and second wavelengths, and the detected light signals are recorded. The detected signals are processed to derive at least a measure of the aerosol particle size. This can be used in combination with the other parameters which are conventionally measured, namely the aerosol density and flow velocity. Thus, optical measurement (possibly in combination with an air flow measurement) can be used to estimate the aerosol output rate as well as the particle size.

Abstract: A system and method for performing flow cytometry is disclosed wherein the alignment of the light source with respect to the sensing region of the fluid stream is continuously controlled using a feedback control loop. An imaging apparatus is provided that images the system along the optical axis, between the field stop and the sensing region. In an embodiment, the cytometer includes a field stop having an H-shaped aperture and light diverters over the ends of the aperture that divert a portion of the light to peripheral detectors.

Abstract: A method of using a light detection system for increasing the accuracy of a precision airdrop is described. Radiation is transmitted to target areas between an airborne vehicle and a dropzone target. Scattered radiation is received from the target areas. Respective wind characteristics are determined from the scattered radiation and a wind velocity map is generated, based on the respective wind characteristics, between the airborne vehicle, and at least the dropzone target. An aerial release point for the precision airdrop is computed based on the generated wind velocity map and a location of the dropzone target.

Abstract: In order to reduce a calculation time of a particle size distribution, a particle size distribution measuring apparatus includes an operation part for receiving light intensity signals outputted from photodetectors and calculating a particle size distribution of the particles based on the fact that a vector s is represented by a predetermined expression including a product of a vector q and a coefficient matrix K, and the operation part is adapted to calculate values of a plurality of first parameters that depend on the particle sizes of the particles and a plurality of second parameters that depend on spread angles of the diffracted/scattered lights, wherein the first and second parameters are used for calculating one element among elements of the coefficient matrix K, and at least one of these calculated values is stored to be used for calculating another element of the coefficient matrix K.

Abstract: The particle size distribution measuring device 1 is so configured to calculate the particle size distribution with repeating several times a process to give the particle size distribution calculated by means of one iterative solver to the other iterative solver as an imaginary solution and to update the calculated particle size distribution as a new particle size distribution.

Abstract: A fine particle measurement device includes a 4f optical system in an optical path that causes a beam spot of a laser output from a light source to form an image with respect to fine particles.

Abstract: A method for the determination of the degree of contamination of an examination object, such as a system for filling liquid foodstuffs, or a component or subsection of a system, in particular a pipe, including measuring a property distribution of a first examination medium before and after passage through the examination object.

Abstract: Methods of detecting bacterial contamination in a platelet concentrate are performed using a dynamic light scattering (DLS) instrument and a sample holder. A sample of platelet concentrate can be held vertically or horizontally in a capillary in the sample holder. Alternatively, novel platelet storage bags modified to include an optically translucent window can be held within another variant of the sample holder. Still alternatively, platelet storage bags having one or more tubes detachably appended to the bag can be used. A sample is drawn off into an appended tube for placement directly into the sample holder. This method provides a number of related, non-invasive techniques for detecting whether bacteria has contaminated a platelet concentrate. Contamination indicators include a population of particles different from platelets, microparticles or proteins, bad-quality platelets, i.e. low DLS score, and very high or very low scattering intensity.

Abstract: In one embodiment, the dimensions of nanoparticles are determined by focusing light on a sample of nanoparticles suspended in a solution, collecting light scattered by the nanoparticles, measuring translational and rotational decay rates of the collected light, calculating a ratio of the rotational decay rate to translational decay rate, and estimating a first dimension of the nanoparticles based upon the decay rate ratio.

Abstract: Apparatus are described for measuring the characteristics of colloidal particles suspended in transparent media by Dynamic Light Scattering (DLS) and Depolarized Dynamic Light Scattering (DDLS) into regions where conventional measurements are difficult or impractical. Matching the diameter of an illuminating beam and an intersecting diameter of a field stop image extends measurements into regions that include concentrated turbid suspensions that frequently appear so visually opaque that multiple scattering typically gives a falsely low estimate of particle size.

Abstract: The invention relates to a method for determining the size d of a transparent particle, according to which method the particle is illuminated with light from a light source, a radiation detector measures a time-resolved intensity profile of light of the light source scattered by the particle, a reflection peak (10) and a refraction peak are determined in the intensity profile and the size d of the particle is determined based on a time difference between the reflection peak (10) and the refraction peak.

Abstract: An airborne, gas, or liquid particle sensor with an on-board data acquisition system that can be used to capture detailed particle pulse information. The information can be used both for on-board analysis and reporting as well as off-line analysis and reporting.

Abstract: A chromatographic optical detection system includes an optical detector disposed to receive light scattered from a stream of particles and configured to convert the received light to an electrical signal; a signal-processing unit in signal communication with the optical detector to receive the electrical signal, and configured to convert the electrical signal to digital pulses and count the digital pulses to output a first signal corresponding to a number of particles detected in a time interval, and configured to integrate and digitize the electrical signal to output a second signal corresponding to the number of particles detected in the time interval; and a data station in signal communication with the signal-processing unit, and configured to select the first signal, if the number of particles detected in the time interval is less than a threshold criterion, and to select the second signal if the number of particles detected in the time interval exceeds the threshold criterion.

Abstract: Methods for using focused light scattering techniques for the optical sensing of biological particles suspended in a liquid medium are disclosed. The optical sensing enables one to characterize particles size and/or distribution in a given sample. This, in turn, allows one to identify the biological particles, determine their relative particle density, detect particle shedding, and identify particle aggregation. The methods are also useful in screening and optimizing drug candidates, evaluating the efficacy and dosage levels of such drugs, and in personalized medicine applications.

Abstract: A particle detecting system includes an airborne particle detecting device that detects scattered light and/or fluorescent light produced through illuminating with light a particle included in a gas, a gas inspection flow path that introduces, into the airborne particle detecting device, a particle included in a gas that is subject to inspection, an aerosol generating portion that generates an aerosol from a liquid that is subject to inspection, and a liquids inspection flow path that introduces a particle included in the aerosol into the airborne particle detecting device.

Abstract: Apparatus and methods are described for determining information about at least one particle by measuring light scattered from the particles. Scattered light is detected from a region of a particle dispersion or from a larger region in a generally collimated illumination beam. Scattered light is also detected from a plurality of regions for improvement of repeatability.

Abstract: In-line holography to create images of a specimen, such as one or more particles dispersed in a transparent medium. Analyzing these images with results from light scattering theory yields the particles' sizes with nanometer resolution, their refractive indexes to within one part in a thousand, and their three dimensional positions with nanometer resolution. This procedure can rapidly and directly characterize mechanical, optical and chemical properties of the specimen and its medium.

Abstract: The subject of the present invention is a pure monomeric bovine serum albumin, a method of producing it characterised by the use column chromatography in resin and a method of identifying it using dynamic light scattering.

Abstract: The present disclosure relates to a system for optical detection of particles arranged in a viewing area suitable for being illuminated by radiation with a predetermined wavelength. The system includes an optical detector, and an assembly of metal plasmonic channels arranged in a single plane of which one end is close enough to the viewing area to allow optical information to be transferred from one end to the other of the channels. The channels are arranged such that the assembly forms an array for transferring optical information around the viewing area. The value of at least one spatial characteristic of the array is respectively lower and higher than the wavelength near the ends of the channels that are respectively close to and far away from the viewing area. The system includes an optical decoupler between the ends that are far away from the viewing area and the optical detector.

Abstract: A method of particle separation, wherein a collimated light source operable to generate a collimated light source beam is provided. The collimated light source beam includes a beam cross-section. A body is provided, wherein the body defines a wall and a first channel in a first plane. The first channel includes a first channel cross-section, the first channel being oriented to receive the collimated light source beam such that the beam cross-section completely overlaps the channel cross-section. The collimated light source beam is transmitted through the channel. A fluid sample is transmitted through the channel, fluid sample including a plurality of particles of a same type. All of the particles of the plurality of particles are separated axially along the collimated light source beam. All of the particles of the plurality of particles are retained against the wall in the collimated light source beam.

Abstract: One embodiment of the present invention provides for a method for identifying within a single record the location of each of a plurality of samples suspected of containing particles of interest wherein the single record is obtained from a flowing stream of the plurality of samples passing through a particle analyzer. The method comprises introducing into a conduit the plurality of samples suspected of containing particles of interest wherein each ones of the plurality of samples are separated by fluid gaps to produce a plurality of samples separated by fluid gaps and wherein each of the plurality of samples further comprises marker particles. The plurality of samples separated by fluid gaps are flowed through the conduit as a flowing sample stream to a detector of a particle analyzer. The particle analyzer is for example a flow cytometer. The particles of interest when present and/or marker particles are detected as the plurality of samples pass the detector of the particle analyzer.

Abstract: Method and apparatus are described for improving measurements of scattered light from particles by controlling multiple scattering and coincidence count levels. The scatter path in the particle dispersion and particle concentration are adjusted to reduce multiple scattering in ensemble particle scattering measurement. And the particle dispersion volume and particle concentration are adjusted to reduce coincidence counts in single particle scattering measurements. Alignment of the optical system, for measuring scattered light, is maintained by a reflection apparatus.

Abstract: A method for directly illuminating a Coulter aperture so light scattering can be incorporated into the classical Coulter aperture and 3-diff blood analyzer to realize full functional hematology analyzer by providing a flow chamber which is separated into two portions by a plate having a Coulter aperture; and using a light source to directly coaxial illuminate the Coulter aperture wherein the illuminating beam propagates in the same direction as the axis of the Coulter aperture and the cell's moving direction.

Abstract: The present invention relates to a non-invasive method for surveilling mixing and separation of a suspension in an analytical system using solid phase particles for separation of an analyte by measuring particle distribution with a camera attached to a pipetting device.

Abstract: A method includes determining particle size distribution (PSD) in a fluid flow line based on a range of sizes for at least one particle in the fluid flow line and duration of reflection of a laser beam from the at least one particle. The laser beam is focused from a laser beam instrument in direct contact with the fluid low line.

Abstract: A localized dynamic light scattering measurement system includes a beam displacer for splitting an incident beam having two orthogonal linearly polarized beam components with slightly different frequencies into two orthogonal linearly polarized output beams focused onto an object to be measured. The beam displacer cooperates with an iris to collect and recombine scattering beams each reversely backscattered at 180 degrees from the object so as to form a signal beam, which is polarized by a polarizer to produce two polarization components, thereby generating a heterodyne interference signal associated with the polarization components. A signal processing unit obtains measurement data on the object based on power spectrum or autocorrelation data corresponding to the heterodyne interference signal.

Abstract: Apparatus are described for measuring the characteristics of colloidal particles suspended in transparent media by Dynamic Light Scattering (DLS) and Depolarized Dynamic Light Scattering (DDLS) into regions where conventional measurements are difficult or impractical. Matching the diameter of an illuminating beam and an intersecting diameter of a field stop image extends measurements into regions that include concentrated turbid suspensions that frequently appear so visually opaque that multiple scattering typically gives a falsely low estimate of particle size.

Abstract: Automated islet measurement systems (AIMS) in combination with tissue volume analysis (TVA) software effectively gauges volumetric and size-based data to generate heretofore unavailable information regarding, for example, populations of islet cells, stem cells and related desiderata.