Abstract: The present invention relates to apparatus for the imaging of single molecules.

Abstract: Disclosed is an observable centrifugal apparatus capable of checking in real time a state of a sample during reaction of separation or synthesization in the form of a stable and high-quality image at a high frame rate. An observable centrifugal apparatus A has a rotary disc 4 rotating about a rotary shaft 2, a reactor 6 disposed on the rotary disc and rotating together with the rotary disc while accommodating a sample, and a microscope 8 for observing a state of the sample within the reactor, in which predetermined substances of the sample are separated or synthesized by applying a centrifugal force to the sample within the reactor.

Abstract: A stage drive for moving a microscope stage designed as a mechanical stage including a first drive element linked to a first output element, and a second drive element, which is linked to a second output element. Through first and second transmission means, the first output element is linked to a first stage element and the second output element is linked to a second stage element of the mechanical stage supported by the first stage element. The stage elements are supported so as to be displaceable relative to a fixed base element in orthogonal directions X, Y in a plane extending normal to the optical axis of the microscope beam path. The at least one stage drive includes at least one drive element and at least one output element and is arranged in the base element so as to be displaceable in X direction and/or Y direction within an adjustment range and lockable.

Abstract: Method for, in particular, optical examination of the surface of a sample carrier for biological objects, in which the sample carrier is arranged in the spatially-fixed observation area of a measuring facility, whereby the observation area covers a partial area of the surface of the sample carrier, and the sample carrier is moved with respect to the observation area, whereby, for examination, the sample carrier is displaced in the direction of an axis that extends in the plane of the sample carrier and rotated simultaneously in this plane.

Abstract: There is disclosed a platform suited for use in dual camera, stereoscopic digital cinema. The fixture may have a base, a first convergence plate and a second convergence plate. The base may be mounted to a tripod, steadicam, crane, boom or other device for supporting a platform used in stereoscopic cinematography. The base may have two platforms attached to each other via a linear slide. The convergence plates may be attached to the respective platforms via an XY slide.

Abstract: A sample positioning stage for positioning a sample to be inspected relative to an optical inspection device, including a first generally planar body on which a sample can be carried and a second body directly coupled to the first body via at least one rigid bearing and at least one resiliently compliant bearing provided between the first and second bodies. The first and second bodies are preloaded against each other in a dimension substantially parallel to the plane of the first generally planar body via the bearings. The stage also includes a motorized drive system operable to drive the first and second bodies relative to each other in the first plane toward a demanded relative position received from a position input device, and a position sensing device on at least one of the first and second bodies, for providing a measure of the relative position of the first and second bodies.

Abstract: A microscope system that shifts a plurality of observation locations that are set upon an observation subject in order onto an optical axis of an objective optical system, and for each of the observation locations, performs photography with an image-capturing device of an observation image of the observation subject a plurality of times as time elapses, includes: a drive unit that drives a stage upon which the observation subject is mounted, and the objective optical system, relative to one another two dimensionally in directions orthogonal to the optical axis; a position detection unit that detects at least one of positions of the stage and the objective optical system; and a correction unit that, based upon position information detected by the position detection unit, performs trimming correction upon a plurality of photographic images that have been photographed at each observation location as time elapses, so that the plurality of photographic images become images of a same observation region that include

Abstract: An examination apparatus that has a simple structure and that is capable of determining the condition inside the apparatus and improving the ease of use of the apparatus when a specimen is changed is provided. The examination apparatus includes a stage on which a specimen is disposed; an optical system configured to form an enlarged or reduced image of the specimen; a cover configured to cover the stage and the optical system; an opening and closing member provided as part of the cover; a detection unit configured to detect whether the opening and closing member is in a closed state or an open state; and a stage driving unit configured to move the state. Only when the detection unit detects that the opening and closing member is open, the stage is moved by the stage driving unit to the outside of the cover through an opening covered by the opening and closing member.

Abstract: A scanning boom microscope comprises an optical axis that can be varied into any axis or direction relative to a circular displacement about an optical boom that supports the scanning boom microscope's objective in free space. Accordingly, scanning boom microscope can be positioned to observe free standing samples away from the microscope base.

Abstract: Methods and systems for scanning a cytological specimen carried by a slide. Movement or positioning of a motorized stage of an automated screening system may be controlled manually by a user such that the user controls movement, e.g., controlling speed, position, and/or timing, of the motorized stage along a first scan line to controllably scan a first portion of the specimen along the scan line. The user may then index the motorized stage from the first scan line to the next scan line and manually control movement of the stage along the second scan line to controllably scan another portion of the specimen. Stage indexing may also be automatic such that the user does not control or initiate indexing.

Abstract: Apparatus for single-handed control of a microscope are disclosed. In one embodiment, a first controller, such as a first rotary controller, is configured for manipulation by a hand of a user to adjust a position of a microscope stage. Another controller, such as a second rotary controller, is configured and arranged relative to the first rotary controller for manipulation by an extended finger of the same hand to review, e.g., scroll through, previously identified portions of a biological specimen while the user's first hand may or may not remain in contact with the first rotary controller. In this manner, the user may continue to review the previously identified specimen portions without having to look away from the microscope.

Abstract: A microscopy system includes an objective lens and a stage for holding a sample. The objective lens focuses incident light coming from one side of the objective lens to the sample disposed on the other side of the objective lens, and focuses an optical signal emitted from the sample to a photosensor disposed on the one side of the objective lens. The stage supports the sample and is configured to be revolvable about an axis, which is substantially perpendicular to an extending direction from the sample to the objective lens.

Abstract: A microscope stage capable of always heating the entire culture vessel even when the culture vessel is moved in two-dimensional directions, and allowing an object lens and a condenser even in a high-power microscope to approach an object of observation such as a cell until they come into focus. A heating unit (58) faces a well plate (37) on a drive base (49) even when the drive base (49) is driven to any position in two-dimensional directions. Therefore, all the cells A in the small compartments (45) of the well plate (37) are always heated. Since the microscope stage (25) is constituted such that a lower-side base (71) houses an upper-side base (73) and a fixed base (47) in recessed portions, its thickness is considerably small. Accordingly, an object lens (5) and a condenser (3) can approach close to the cells A. Therefore, it is possible for high-power object lens (5) and condenser (3) to focus on the cells A.

Abstract: An x-ray microscope stage enables alignment of a sample about a rotation axis to enable three dimensional tomographic imaging of the sample using an x-ray microscope. A heat exchanger assembly provides cooled gas to a sample during x-ray microscopic imaging.

Abstract: A scanning microscope for the optical measuring of an object in which a measurement beam emitted by the light source impinges the object and is reflected by the object as a reflection beam that reenters through the lens into the radiation path of the microscope. A scanner control unit controls a displacement to change the relative position of the object and the measuring beam so that the beam is directed to at least two different measuring points on the object. An excitation unit periodically excites the object. The reflection beam is visualized on a signal detector, and a signal storage unit saves a measuring sequence of signals of the signal detector. The scanner control unit cooperates with the excitation and signal storage units to control them such that for each measuring point on the object at least one measuring sequence of measuring signals of the signal detector is saved.

Abstract: An actuating mechanism includes a scanner chip having a scan table mounting cavity, and a bracket moveably positioned in the scan table mounting cavity. A scan table is moveably positioned in the bracket. The bracket has a first mass and the scan table has a second mass. A first coil and frame collectively define a third mass and a second coil and frame collectively define a fourth mass. A first pivoting element is connected to the first coil and the scan table. The first pivoting element is pivotally supported about a first pivot point and connected though an asymmetrical leverage connection to the first coil and the scan table. A second pivoting element is connected to the second coil and the scan table. The second pivoting element is pivotally supported about a second pivot point and connected through a symmetric leverage connection to the second coil and the scan table.

Abstract: A slide photograph data creation system includes a digital camera for making high-magnification photographs of samples, a sample transporter for holding and transporting samples, a controller for controlling the camera and the sample transporter so as to provide overlapping photographs, a pasting information generator for recognizing the margin by which the photographs overlap and for generating pasting-together information, and a photograph file generator for storing in a single file a plurality of high-magnification photographs and the pasting-together information. The system facilitates the examination and photography of large numbers of samples, and enables discrimination of the three-dimensional structure of a sample. Since the photographic data is managed with a database, virtual slide photographs and their attributes information can be browsed over a network or the Internet.

Abstract: A positioning mechanism capable of decreasing width and size and a microscope using the positioning mechanism are provided. The positioning mechanism is provided with a supporting shaft possessing a spherical surface part at a prescribed position and guides disposed substantially parallel to the supporting shaft and is characterized, on the assumption that of the three-dimensional directions, the axial direction of the supporting shaft constitutes the z direction, by the fact that the supporting shaft is nipped by the guides at the position of the spherical surface part and enabled to oscillate on the spherical surface part as a fulcrum in the xy directions and as well slide in the z direction.

Abstract: A slide holder (6) for use with a microscope to accurately locate a slide (19) in position under the microscope has a pivotal lever (13) having a clamping and locating portion (14) with abutments (15) and (16) which bear on respective edges of the slide when it is in the clamped position. Further abutments (10) on a fixed angular plate (9) locate the other edges of the slide. The slide holder is adapted for mounting on a slide translation stage of a slide loader (1) which includes a stationary sensor block (20) positioned to engage the lever (13) when the slide holder moves from its inspection or scanning position under the microscope to a loading/unloading position. The slide translation stage includes a robotic head for lifting and depositing slides and the translation stage includes a bar code reader to read a bar code on the slide.

Abstract: A microscope system comprises a microscope for observing a sample, a stage on which the sample is mounted, a stage driving unit for moving the stage, and a control unit for controlling the stage driving unit in such a way that acceleration generated by a movement of the stage does not exceed a predetermined value, when the stage is moved with respect to the optical observation axis of the microscope and the stage is relatively scanned by the optical axis.

Abstract: An actuator system for making a nanoscale movement of an object is provided. In the actuator system, a platform supports the object. A Z-axis actuator connects the platform to the object in a Z-axis direction, and moves the object in the Z-axis direction by Z-axis direction transformation. A frame supports the platform around the platform. An X-axis actuator connects the frame to the platform in an X-axis or Y-axis direction perpendicular to the Z-axis, and moves the object in the X-axis direction by transformation in the direction perpendicular to the Z-axis.

Abstract: A microscope system includes a casing in which an optical element is housed, an airtight specimen chamber, and an environment control unit that controls temperature and humidity in the specimen chamber and also controls temperature inside the casing. An upper plate of the specimen chamber is an open/close lid opened and closed when inserting or removing a biological specimen. The casing becomes sealed by a bottom plate of the specimen chamber as the specimen chamber is set on the casing.

Abstract: A stage movable in the X and Y directions includes a base member, first and second moving members, and first and second rotational operation mechanisms. The first moving member is provided with a movement transmission mechanism that allows linear movement of the second moving member in a first direction and causes, when the first moving member moves in a second direction, the first and second moving members to move together in the second direction, and the second moving member is provided with a transmission portion that engages a linear movement member so that it moves upon movement of the linear movement member. The linear movement member transmits movement to the transmission portion to cause the second movement member to move in a first direction and guides the transmission portion upon linear movement of the first and second moving members in the second direction by the movement transmission mechanism.

Abstract: A motorized table apparatus comprises: a support unit for supporting a movement table so as to allow it to move in a single axis direction relative to a stationary unit which is fixed to the movement table; a slide member which is equipped on the movement table and which has a length equivalent to, or more than, a moving range of the movement table; an ultrasonic oscillators which is equipped on the stationary unit, which moves the movement table, and which comprises a single piezoelectric body and two drive elements; and a pressure application unit for supporting so that the two drive elements of the ultrasonic oscillator and the slide member are pressed by a constant force, wherein a plurality of the ultrasonic oscillators are equipped.

Abstract: An interchangeable microscope stage drive assembly, including a microscope stage, and, a drive mechanism detachably secured to the microscope stage at more than one location of the stage.

Abstract: An alignment method of micro-alignment members includes a first step for moving a reticle, which is movably disposed between a first position and a second position, to face a first microscope in the first position, and for aligning a center of the reticle with an optical axis of the first microscope while observing the reticle by the first microscope, a second step for moving the reticle to the second position to face a second microscope in the second position, and for aligning the center of the reticle with an optical axis of the second microscope while observing the reticle by the second microscope, a third step for disposing a first micro-alignment member such that a center of the first micro-alignment member aligns with the optical axis of the second microscope, and a fourth step for disposing a second micro-alignment member instead of the reticle to face the first micro-alignment member.

Abstract: The invention includes an apparatus for controlling a microscope stage assembly having a rod for moving the stage in two directions. The rod is detachably secured to the microscope stage assembly. The rod includes at least one substantially circular stick with an attachment end and a gripping end. The attachment end is arranged to be detachably secured to the microscope stage assembly. The invention also includes an interchangeable microscope stage movement device for providing X and Y movement of a sample. The device includes a microscope stage assembly and a joystick detachably secured to the stage assembly at more than one location of the stage assembly.

Abstract: A wide field of view scanning microscope includes a light source, a light detector, optics, a scanning assembly, a translation system, and a data collection control and processing unit. The scanning assembly is constructed to provide from the light source a light beam in a scanning motion to an examined surface. The optics includes an objective lens associated with the scanning assembly arranged to provide an optical path to the light detector. The translation system is constructed to produce a movement of the examined surface. The data collection control and processing unit is arranged to collect data during the scanning motion and process the collected data.

Abstract: A developing apparatus is capable of moving a stage for supporting a substance to be developed from a detachable position to a developing area below a developing unit, and two-dimensional movement. The present developing apparatus includes a developing device, a first moving device movable in a direction of axis of ordinate and a second moving device movable in a direction of axis of abscissa, and a stage posture control device to control an inclined posture of the stage in order to hold a relative distance between the developing device and a developing area surface of the substance placed on the stage constant.

Abstract: A method and apparatus is provided for scanning an object, featuring scanning an incident beam in a substantially curved scan pattern; and moving an object at a predetermined rate along an axis substantially orthogonal to a plane of the curved scan pattern so that a two dimensional image can be formed by successive passes of a circularly scanned spot. In particular, a laser beam scans around an objective lens at a fixed radius RL with a fixed input angle ?d. When scanned in this manner, the laser beam before the objective lens forms a “cone” of directions (so herein it is referred to as a “conical scan”). Scanning in this fashion produces the curved scan pattern at the object (substrate). By moving the object (substrate) at the predetermined rate along the axis orthogonal to the plane of the curved scan pattern, the two dimensional image can be formed by successive passes of the circularly scanned spot.

Abstract: Concentration by cytology personnel, i.e. users, is induced during scanning and marking of cytology slides, by electronic recognition of parsed voice inputs that are spoken by the users, electronic generation of selected voice output alerts that are heard by the users, and electronic processing of the voice inputs and voice outputs, for semi-automatic development of a cytology report.

Abstract: A stage assembly mountable on an optical microscope for orienting a sample into a desired focal position includes an X-axis plate operable for rectilinear shifting in the X-axis direction and a Y-axis plate mounted on the X-axis plate operable for rectilinear translation in the Y-axis direction. A Z-axis plate is mounted on the XY plate assembly for carrying a sample to be investigated and a piezoelectric actuator mechanism is interposed between the XY plate assembly and the Z-axis plate operable for rectilinear translation of the Z-axis plate.

Abstract: A microscope having a moveable object holder forming a part of a stage assembly. The stage assembly includes at least one x-y control, for moving the stage assembly or a portion thereof, e.g. the object holder, in a horizontal x direction, which x direction is parallel to the shoulders of an operating microscopist sitting square to the microscope, and for moving the stage assembly or portion thereof in a horizontal y direction perpendicular to the x direction. The microscope has dual controls for moving the stage assembly or a portion thereof in a z direction perpendicular to the x-y directions and parallel to an optical path into an objective lens of the microscope, wherein the x-y control and z controls are located so as to permit single hand operation of both controls with minimal hand movement or so as to permit comfortable ergonomic dual hand operation while permitting the shoulders of an operating microscopist to remain aligned parallel to the x direction.

Abstract: A control system of a stage of a microscope includes: a stage transfer unit for transferring the stage for loading a sample perpendicular to an optical axis of the microscope; a transfer command acquisition unit for obtaining command information for a transfer of the stage; a stop position direction storage unit for storing stop position direction information which is information generated according to the command information obtained from the transfer command acquisition unit, and the information about a position and direction when an operation of the stage transfer unit is stopped; and a stage transfer control unit for controlling an operation of stage transfer unit according to the stop position direction information stored in the stop position direction storage unit.

Abstract: The invention is directed to an arrangement for manual adjustment of a focus position in microscopes with a motor-operated focusing drive. According to the invention, the arrangement has a first operator's control for giving an adjusting path length and a second operator's control for giving an adjusting speed. The two operator's controls are preferably constructed as rotating knobs. An adjusting path length for the focusing movement is given by the rotational angle at the first rotating knob, and an adjusting speed of the focusing movement is given by the rotational angle at the second rotating knob. The change in the rotational angle at the first rotating knob is proportional to the change in the adjusting path and the change in the rotational angle at the second rotating knob is proportional to the change in the adjusting speed.

Abstract: In a confocal laser microscope, a confocal image and a non-confocal image of an observation target are generated from light reflected by the observation target, and the confocal image and non-confocal image are displayed side by side on the same screen.

Abstract: The invention relates to a device for positioning a biological sample analysis plate on an observation device comprising an observation lens and a chassis having a plate support assembly [20]. This assembly comprises a first frame [21] and a second frame [22] able to slide in a plane perpendicular to the observation axis, assumed to be vertical, with the first and second frames each able to move in a direction perpendicular to the direction of movement of the other frame; and a third frame [23] supported by the second frame [22] by means [30] used to maintain said third frame in a plane perpendicular to the observation axis, while leaving the movement free in a vertical plane.

Abstract: The apparatus for automatically focusing an image in a microscope includes onto an object plane includes an optical system configured to form an optical image of a sample plane to be observed, an autofocusing detection system, and a focus correction system. The autofocusing system includes an autofocusing light beam source for generating autofocusing light beams. The autofocusing system further includes a detection system lens for directing autofocusing light beams to an autofocusing detection device, and an autofocusing detection device for determining the amount of displacement of the image of the object plane from a desired focused reference plane. The focusing correction system includes a feedback controller and focus adjusting device for automatically adjusting the distance between an objective lens and the sample plane in order to properly focus the image in the optical system. A related method of automatically focusing an image of an object plane in a microscope.

Abstract: A new arrangement for the revolving stage of a polarizing microscope is presented. A stage well adapted to be removably fitted into and attached to the center of a revolving stage is provided with a housing, an inner sleeve adapted to fit within the housing and to move vertically within the housing, and a sample platform. In a preferred embodiment, the inner sleeve also moves rotationally. The stage well extends below the upper surface of the revolving stage with sufficient clearance to avoid interference with condenser and/or other components present below the revolving stage. Also presented is a microscope stage assembly comprising a revolving stage and a stage well attached to a center opening in the microscope revolving stage.

Abstract: The invention concerns a surgical microscope having a stand and having an optics carrier (7a) joined movably to the stand and mounted movably with respect to the stand. The optics carrier (7a) is mounted, in the region of its center of gravity, pivotably about at least one axis (17a) with respect to a pivot support (6a) of the stand. At least one of the pivot axes (17a) is constituted virtually by the center of an arc-segment-shaped guidance element (10a) that coacts with a guide carriage (11a).

Abstract: A two axis stage for microscopes that is thin, has reduced vibration, and is adapted for increased stage transportation speeds is capable of being disposed inside a chamber without changing a floor-projected area. The XY stage comprises a base 1, an X table 2 that can be moved in an X direction on the base 1 by an X feed screw 7, and a Y table 3 that is supported on the X table 2 and movable in a Y direction. A third table 4 is disposed on the base 1, the third table being movable in the Y direction by a Y-feed screw 8 positioned on the base 1. Additionally, a slide unit 14 is disposed on the third table 4, the slide unit 14 being movable in the X direction and connected with the Y table 3.

Abstract: In a microscope, an optical system that includes a zoom lens unit having a straight optical axis is located under a stage portion that carries a sample A thereon. An optical image of the sample A is projected on an image-pickup element via the optical system, and is converted into a picture signal by means of the image-pickup element. The picture signal is delivered to the outside through an external terminal area.

Abstract: A microscope for inspecting a semiconductor wafer includes an optical unit including objective lenses and oculars for observing the semiconductor wafer; a display unit for magnifying and displaying an image of the semiconductor wafer observed by the optical unit; a sample piece stage holding the semiconductor wafer; a stage moving unit for moving the semiconductor wafer in an x-axis direction, a y-axis direction or a z-axis direction; a stage rotation unit for rotating the semiconductor wafer in a horizontal direction; a stage tilting unit for tilting the semiconductor wafer; and a controller for controlling operation of the microscope.

Abstract: The invention concerns a holder (1) for positioning a specimen slide (2) on a microscope stage (7), having a baseplate (3), retainable on the microscope stage (7), in which is configured, for reception of the specimen slide (2), an opening (3a) comprising flat support surfaces (3b) and at least one abutment surface (3c), extending substantially perpendicular to the support surface (3b), for the specimen slide (2); and having at least one spring element (4) with which, by means of a compressive force (F) acting substantially horizontally, the specimen slide (2) arranged in the opening (3a) of the baseplate (3) can be pressed against the at least one abutment surface (3c) of the opening (3a).

Abstract: The slide handler is an instrument that automatically transfers glass microscope slides from a cassette or magazine to a motorized microscope stage and then returns the slide back into the second cassette. The use of this instrument permits the unattended computer control, measurement and inspection of specimens mounted to the slides. Full modular integration of the system components allows for the slide handler instrument to be utilized with any microscope. The instrument system has a minimum of three components; namely a slide cassette indexer, an XY-stage, and a slide exchange arm. The indexer, the arm and the XY-stage are connected together and integrated into one unitary modular instrument that can be moved from one microscope to another.

Abstract: A microscope system includes: a stage that shifts a specimen in x and y directions; a detection section that detects a position of the stage after shifting; a reception section that receives an input of a shift target position for the stage inputted by an observer; an optical system that forms a light flux into a focused and magnified image of the specimen; an image capturing section that captures the magnified image; and a shift section that, if the position detected by the detection section and the shift target position received by the reception section do not agree with one another, shifts a relative positional relationship between the light flux and the image capturing section.

Abstract: A microscope stage of this invention includes an upper stage, a handle shaft rotatably supported on the upper stage, a pulley rotatably supported on the upper stage in a position different from the handle shaft, a lower stage directly driven and guided with respect to the upper stage and a transmission member for interlocking the handle shaft, pulley and lower stage.

Abstract: A Z-axis stage for use in, e.g., an orthogonal motion microscope stage, includes a carrier plate, an actuator plate, and a base. Three or more upper camming elements with downwardly directed camming surfaces are mounted to the underside of the carrier plate using a semi-kinematic mounting technique. Three or more lower camming elements with upwardly directed camming surfaces are mounted to the top surface of the base using a semi-kinematic mounting technique. The actuator plate includes apertures to accommodate the lower camming elements and the upper and lower camming surfaces of adjacent camming elements are mated. Linear slides are interposed between the mated camming surfaces and the lower camming elements and the base. Movement of the actuator plate in an X-Y reference plane translates into movement of the carrier plate along the Z-axis (i.e., the optical axis) in response to the relative, sliding motion of the mated camming elements.

Abstract: A microscope stage providing improved optical performance. A carriage for supporting an object has a transparent portion for receiving the object and permitting trans-illumination thereof. A base supports the carriage, at least a portion of the base comprising a transparent material to permit illumination of the specimen there through. Bearings disposed between the base and the carriage support the carriage on the base and permit relative movement thereof. The base has a dovetail cross sectional shape with bearings between the top of the carriage and the base and between the sidewalls of the carriage and the base. A cover is coupled to the carriage so as to transfer force thereto without imparting a significant movement thereto. A mechanism connected to the cover for moving the carriage relative to the base is disposed at a position offset from the axis of lateral symmetry of the carriage and base.

Abstract: The invention is a solid state process for analyzing genomes by visualizing sequence specific markers (e.g., proteins that bind a defined DNA sequence elements) by scanning probe microscopy. The method includes linear display of the nucleic acid on a solid surface, image acquisition by the scanning probe microscope, and digital data analysis. The acts of the method result in a bar code type display of each fragment of the DNA sample. These bar codes are then used to place the fragments in the order they appear on the original DNA sample.