Abstract: A sterilizing tunnel for pharmaceutical containers has an entry zone, a heating zone, and two cooling zones. The individual zones contain ventilating fan units that generate air currents, which serve to heat and cool the containers that a transport apparatus conveys through the sterilizing tunnel. The heating and cooling units, which operate using the principle of heated and cooled air flow, is supplemented with radiant heat-generating unit. The sterilizing tunnel makes it possible to achieve a uniform heating and cooling of the containers, preventing stress cracks in the containers and permitting intentional heating that makes it possible, for example, for the containers to be coated with a substance.

Abstract: The present invention generally relates to the field of pharmaceutical sciences. More specifically, the present invention includes apparatus and devices for the preparation of pharmaceutical formulations containing large diameter synthetic membrane vesicles, such as multivesicular liposomes, methods for preparing such formulations, and the use of specific formulations for therapeutic treatment of subjects in need thereof. Formation and use of the pharmaceutical formulations containing large diameter synthetic membrane vesicles produced by using the apparatus and devices for therapeutic treatment of subjects in need thereof is also contemplated.

Abstract: A reducing agent container having a multi-function and having a container body thereof is provided with at least a heat exchanger which permits a heating medium using an engine as a heat source thereof to circulate therein for performing the heat exchange with a liquid reducing agent and a strainer which filtrates foreign substances from the liquid reducing agent, the heat exchanger and the strainer being attached to a top board of the container body. Further, a suction pipe capable of sucking the liquid reducing agent from the inside of the container body is connected to the strainer, and a supply port for the liquid reducing agent from which the foreign substances are filtrated is formed in the strainer. Thus, the whole of strainer is not exposed to the outside air, especially, the wind during traveling, and accordingly, the freezing of the urea aqueous solution in the strainer can be suppressed.

Abstract: When a polyethylene bag with medical wastes received therein is supplied to a cylindrical-shaped housing and a compression device is used to lower a piston to compress the medical wastes, the piston is repeatedly caused to go up and down to accomplish stepwise compression whereby the polyethylene bag with medical wastes received therein is prevented from entering into a clearance between an inner wall of the cylindrical-shaped housing and the piston and from bursting due to rapid compression, and when cake obtained by melt sterilization and volume reduction with heating compression is discharged, a gate is fully opened to lower a lower surface of a heating device of the piston to a point distant several millimeters from an upper surface of a heating device of the gate to enable forcedly scraping off the cake adhering to the heating device tightly joined to the piston upon closing of the gate.

Abstract: The present invention generally relates to the field of pharmaceutical sciences. More specifically, the present invention includes apparatus and devices for the preparation of pharmaceutical formulations containing large diameter synthetic membrane vesicles, such as multivesicular liposomes, methods for preparing such formulations, and the use of specific formulations for therapeutic treatment of subjects in need thereof. Formation and use of the pharmaceutical formulations containing large diameter synthetic membrane vesicles produced by using the apparatus and devices for therapeutic treatment of subjects in need thereof is also contemplated.

Abstract: The present invention generally relates to the field of pharmaceutical sciences. More specifically, the present invention includes apparatus and devices for the preparation of pharmaceutical formulations containing large diameter synthetic membrane vesicles, such as multivesicular liposomes, methods for preparing such formulations, and the use of specific formulations for therapeutic treatment of subjects in need thereof. Formation and use of the pharmaceutical formulations containing large diameter synthetic membrane vesicles produced by using the apparatus and devices for therapeutic treatment of subjects in need thereof is also contemplated.

Abstract: The present invention generally relates to the field of pharmaceutical sciences. More specifically, the present invention includes apparatus and devices for the preparation of pharmaceutical formulations containing large diameter synthetic membrane vesicles, such as multivesicular liposomes, methods for preparing such formulations, and the use of specific formulations for therapeutic treatment of subjects in need thereof. Formation and use of the pharmaceutical formulations containing large diameter synthetic membrane vesicles produced by using the apparatus and devices for therapeutic treatment of subjects in need thereof is also contemplated.

Abstract: A mobile sanitizer unit for thoroughly sanitizing objects through the use of evenly distributed heat in a mobile trailer. The mobile sanitizer unit generally includes an enclosed chamber positioned upon a trailer vehicle frame for sanitizing objects (e.g. furniture, mattresses, fabric, etc.) within. The chamber includes a heater with that is separated from the contained objects to prevent overheating a specific area of the objects. The heat is circulated via one or more circulation fans. A floor passageway may also be defined for circulating the heated air underneath the objects. A plurality of temperature sensors are used to record the internal core temperature of the objects along with the ambient temperature within the chamber. A separately accessible control room may also be located upon the vehicle frame and include a controller therein for receiving data from the temperature sensors and for controlling the heater and the circulation fans.

Abstract: The present invention generally relates to the field of pharmaceutical sciences. More specifically, the present invention includes apparatus and devices for the preparation of pharmaceutical formulations containing large diameter synthetic membrane vesicles, such as multivesicular liposomes, methods for preparing such formulations, and the use of specific formulations for therapeutic treatment of subjects in need thereof. Formation and use of the pharmaceutical formulations containing large diameter synthetic membrane vesicles produced by using the apparatus and devices for therapeutic treatment of subjects in need thereof is also contemplated.

Abstract: The present invention generally relates to the field of pharmaceutical sciences. More specifically, the present invention includes apparatus and devices for the preparation of pharmaceutical formulations containing large diameter synthetic membrane vesicles, such as multivesicular liposomes, methods for preparing such formulations, and the use of specific formulations for therapeutic treatment of subjects in need thereof. Formation and use of the pharmaceutical formulations containing large diameter synthetic membrane vesicles produced by using the apparatus and devices for therapeutic treatment of subjects in need thereof is also contemplated.

Abstract: The present invention generally relates to the field of pharmaceutical sciences. More specifically, the present invention includes apparatus and devices for the preparation of pharmaceutical formulations containing large diameter synthetic membrane vesicles, such as multivesicular liposomes, methods for preparing such formulations, and the use of specific formulations for therapeutic treatment of subjects in need thereof. Formation and use of the pharmaceutical formulations containing large diameter synthetic membrane vesicles produced by using the apparatus and devices for therapeutic treatment of subjects in need thereof is also contemplated.

Abstract: The present invention generally relates to the field of pharmaceutical sciences. More specifically, the present invention includes apparatus and devices for the preparation of pharmaceutical formulations containing large diameter synthetic membrane vesicles, such as multivesicular liposomes, methods for preparing such formulations, and the use of specific formulations for therapeutic treatment of subjects in need thereof. Formation and use of the pharmaceutical formulations containing large diameter synthetic membrane vesicles produced by using the apparatus and devices for therapeutic treatment of subjects in need thereof is also contemplated.

Abstract: The present invention generally relates to the field of pharmaceutical sciences. More specifically, the present invention includes apparatus and devices for the preparation of pharmaceutical formulations containing large diameter synthetic membrane vesicles, such as multivesicular liposomes, methods for preparing such formulations, and the use of specific formulations for therapeutic treatment of subjects in need thereof. Formation and use of the pharmaceutical formulations containing large diameter synthetic membrane vesicles produced by using the apparatus and devices for therapeutic treatment of subjects in need thereof is also contemplated.

Abstract: The present invention generally relates to the field of pharmaceutical sciences. More specifically, the present invention includes apparatus and devices for the preparation of pharmaceutical formulations containing large diameter synthetic membrane vesicles, such as multivesicular liposomes, methods for preparing such formulations, and the use of specific formulations for therapeutic treatment of subjects in need thereof. Formation and use of the pharmaceutical formulations containing large diameter synthetic membrane vesicles produced by using the apparatus and devices for therapeutic treatment of subjects in need thereof is also contemplated.

Abstract: An apparatus for the heat treatment of a product, especially a food product such as a food product contained within a hermetically sealed container or pouch of plastics or like material, for example for sterilization, pasteurization or cooking, having a heating unit to bring product from ambient towards a heat treatment temperature and pressure; a retort unit to apply a heat treatment to a product; and a cooling unit to allow product to be brought down from heat treatment temperature and pressure towards ambient; wherein each unit and retort is selectably sealable from the others and from ambient conditions.

Abstract: Solutions for limiting the undesirable spread of pathogens by indirect contact are provided. The solutions involve heat-sanitization of contact regions on articles or fixtures by flowing selected electromagnetic radiation energy through underlying waveguide structures substantially parallel to the contact regions.

Abstract: An incense burner and storage device includes a lower housing with a base and a storage compartment. The device also includes an upper housing and an upwardly extending column for supporting the upper housing. The upper housing includes a support for charcoal and incense and an ashtray for collecting ashes. The ashtray is also rotatable about a vertical axis between a loading position and a burning position. The ashtray also includes a perforated screen-like bottom that allows a flame to pass therethrough. A cigarette lighter is used for heating the charcoal and is pivotally mounted within the column for removal and replacement of the lighter. An adjustment mechanism is fixed to one side of the upper portion of the column and allows the charcoal and incense support to be raised or lowered with respect to the cigarette lighter.

Abstract: An apparatus for treating material includes a pressure vessel and an agitation device for agitating the material received in the pressure vessel. The agitation device may include a drum which may be rotatably arranged inside the pressure vessel and which has an inner space for receiving the material that is introduced into the pressure vessel. The agitation device may include one or more agitation blades mounted in the drum so as to act on the material received in the inner space of the drum as the drum rotates in relation to the pressure vessel. A drive mechanism may rotate the drum in relation to the pressure vessel. Waste, such as garbage, may be treated with steam and pressure using the apparatus.

Abstract: Methods of reclaiming plastic from infectious medical waste and manufacturing medical devices from reclaimed plastic are described. Medical devices made from plastic reclaimed from infectious medical waste are also described.

Abstract: A device is disclosed for generating a decontamination agent vapor, in particular hydrogen peroxide vapor. The device includes an evaporator body, a heating unit for heating the evaporator body, and a plurality of feed channels for feeding decontamination liquid to the evaporator body. The decontamination liquid is evaporated by the evaporator body. In one embodiment, the liquid contains hydrogen peroxide. In some embodiments, a plurality of blind holes are provided in a single- or multi-part evaporator body, and at least one of the feed channels is assigned to the blind holes.

Abstract: A device and system is disclosed for sterilizing objects, commonly dental, medical, or veterinary instruments, by enhancing rapid hot air diffusion into an instrument container by means of a sliding cover overlaying an opening in the bottom of the instrument container when in the closed position and sliding horizontally to reveal the opening in the open position, allowing rapidly flowing hot air into the container for medical article sterilization. The sliding cover is moved to the open position just prior to the sterilization process by a mechanical means incorporated into the sterilizer with the sliding cover remaining in the open position through the completion of the sterilization process. Once the sterilization cycle is complete, the mechanical means is reversed, closing, sealing, and locking the sliding cover in place over the opening before the instrument container is removed from the sterilizer, ensuring continued medical instrumentation sterility inside the container.

Abstract: By a method and a device for preventing corrosion on and in the region of a gas inlet nozzle during nitric acid condensation, contact of the condensing gas with the nozzle and with the surroundings of the nozzle are supposed to be minimized. This is achieved in that the gas inlet nozzle has a sleeve on the inside in the transition region to the interior of the condenser, by which sleeve a gas inlet orifice in the form of an annular gap is formed, whereby the annular space is provided with at least one feed opening for secondary air, so that an enveloping flow of secondary air is produced around the entering NO gas.

Abstract: A method for preparing contaminated plastics ground into flakes, such as RPET or such polymers, having at least decontamination and SSP treatment steps, with at least one reactor, with heating to the process temperature taking place essentially outside the reactor. Also, a device for carrying out the method, and having at least one decontamination reactor and at least one SSP reactor, a device for heating plastic flakes to the process temperature being arranged upstream of the decontamination reactor. Also an SSP reactor having at least two individual reactors, and preferably between 3 and 7 individual reactors.

Abstract: A retort system includes a vessel defining a heating chamber and including a product receiving area therein, and a product agitating arm mounted for reciprocating movement through a wall of the vessel and having a first end within the vessel and a second end outside the vessel. A drive arrangement is located exterior of the vessel and operatively coupled to the arm for moving the arm in a reciprocating manner. The drive arrangement includes a crankshaft assembly, a first flywheel and a second flywheel. The crankshaft assembly includes a crank throw operatively coupled to the arm, the crankshaft assembly having a rotational axis offset from the crank throw. The first flywheel is mounted to the crankshaft assembly to a first side of the crank throw for rotation with the crankshaft assembly about the rotational axis. The second flywheel is mounted to the crankshaft assembly to a second side of the crank throw for rotation with the crankshaft assembly about the rotational axis.

Abstract: A burner for production of inorganic spheroidized particles according to the present invention includes a raw material powder supply path that supplies raw material powder by using oxygen or an oxygen-enriched air as a carrier gas; a powder diffusion plate having a plurality of fine holes, which is provided at a downstream end of the raw material powder supply path; a raw material diffusion chamber that is formed in a diffusion pipe provided at a downstream end of the powder diffusion plate; a fuel supply path disposed around the outer circumference of the raw material powder supply path; an oxygen supply path disposed around the outer circumference of the fuel supply path; and a combustion chamber disposed at a downstream side of the raw material diffusion chamber, which has an inside diameter increasing along the downstream direction and communicates with the fuel supply path and the oxygen supply path.

Abstract: An apparatus for sterilizing a medical instrument in a container by applying thermal energy to the container includes a first base member coupled to the container and an elongated member with a first end that couples to the first base member and a second end extending into an interior portion of the medical instrument. The first base member transfers a portion of the thermal energy to the elongated member to heat the interior portion.

Abstract: The present disclosure provides systems and methods for production of nanostructures using a plasma generator. In an embodiment, a system for use with a reactor for synthesis of nanostructures may include a chamber defining a pathway for directing a fluid mixture for the synthesis of nanostructures through the chamber. The system may further include one or more heating zones disposed along the chamber to provide a temperature gradient in the chamber to form catalyst particles upon which nanostructures can be generated from the components of the fluid mixture. The system may also include a plasma generator for generating a plasma flame in a conduit through which the fluid mixture may be passed to decompose a carbon source in the fluid mixture into its constituent atoms before proceeding into the reactor for formation of nanostructures.

Abstract: Reactors for carrying out a chemical reaction, as well as related components, systems and methods are provided. In accordance with one embodiment, a reactor is provided that includes a furnace and a crucible positioned for heating by the furnace. A downtube is disposed at least partially within the interior crucible along an axis. At least one structure is coupled with the downtube and extends substantially across the cross-sectional area of the interior volume taken in a direction substantially perpendicular to the axis. A plurality of holes is formed in the structure enabling fluid flow therethrough. The structure coupled with the downtube may include a lower body portion and an upper body portion coupled with the lower body portion, wherein the plurality of holes is formed in the lower body portion adjacent to, and radially outward from, a periphery of the upper body portion.

Abstract: Biowaste sterilizers are described. In one implementation an exemplary system has waste transport vessels that can be intermittently heated and pressurized, for example, with steam, and are interconnected to provide multiple sterilization pathways for waste as the waste is transported. Selected sterilization pathways may depend on attributes of the waste. Sterilization factors, such as mechanical shredding, application of steam, application of pressure, maintenance of temperature, separation of liquid, etc., are integrated into the waste transport features of the system, which can be made compact to save space while processing relatively large bulk amounts of materials, such as medical wastes. The system maintains safe isolation of bio-hazardous components in the waste from the external environment. A system controller provides parameters management, smart sterilization cycle control, quality assurance, safety management, diagnostics, and reporting over a network.

Abstract: An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations, or modules, in which discrete aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automatically preparing a specimen sample, incubating the sample at prescribed temperatures for prescribed periods, performing an analyte isolation procedure, and ascertaining the presence of a target analyte. An automated receptacle transporting system moves the reaction receptacles from one station to the next.

Abstract: An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations, or modules, in which discrete aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automatically preparing a specimen sample, incubating the sample at prescribed temperatures for prescribed periods, performing an analyte isolation procedure, and ascertaining the presence of a target analyte. An automated receptacle transporting system moves the reaction receptacles from one station to the next.

Abstract: A sterile enclosure contains a transfer module defining a window. A port covers the window to maintain the inside of the enclosure as a sealed and sterile environment. A sliding, heated cutting element mounted on the port serves to sterilize and sever a portion of a sterile transfer bag assembly attached to the port. Preferably, the excised portion of the sterile transfer bag assembly is affixed to the port when the port opens. The sliding cutting element remains extended and heated to prevent contamination when the port is open. Further, a heating element is mounted about the window in order to sterilize around the opening when the port is open.

Abstract: An apparatus for treating objects with a treatment gas comprises a treatment chamber, a chamber input through which objects enter the treatment chamber, and a chamber output (which may be the same as the chamber input) through which the objects leave the treatment chamber. The treatment chamber encloses the treatment gas, which can be steam. The chamber output and/or the chamber input include an intermediate medium, such as a liquid, through which the objects pass. The intermediate medium prevents escape of the treatment gas from the treatment chamber and the ingress of external gases into the treatment chamber, while facilitating input of the objects to the chamber, and output of the objects from the chamber.

Abstract: An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations, or modules, in which discrete aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automatically preparing a specimen sample, incubating the sample at prescribed temperatures for prescribed periods, performing an analyte isolation procedure, and ascertaining the presence of a target analyte. An automated receptacle transporting system moves the reaction receptacles from one station to the next.

Abstract: The invention relates to a device for generating decontamination agent vapor, in particular hydrogen peroxide vapor, comprising an evaporator body (9), a heating unit (22) for heating the evaporator body (9) and a plurality of feed channels (28) for feeding decontamination liquid to be evaporated, preferably a liquid containing hydrogen peroxide, to the evaporator body (9). According to the invention, a plurality of blind holes (16) are provided in the single- or multi-part evaporator body (9), and at least one of the feed channels (28) is assigned to the blind holes (16).

Abstract: A method and an apparatus for sterilizing objects, such as animal cages, are disclosed. The apparatus includes a housing that defines a sterilizing chamber for the objects. The apparatus includes a first air inlet in fluid communication with the sterilizing chamber, and a first air outlet in fluid communication with the sterilizing chamber. The first air inlet and the first air outlet are structured to be placed in fluid communication with a source of dry heat. A second air inlet is in fluid communication with the sterilizing chamber and a source of filtered air. A second air outlet in fluid communication with the sterilizing chamber and an exterior space outside of the sterilizing chamber. Dry heat flows in the first air inlet, over the objects in the sterilizing chamber, and out the first air outlet. Dampers are then closed to seal off the first air inlet and the first air outlet.

Abstract: A dual-mode autoclave for sterilizing a battery is disclosed including a controller and an environmental system in operative communication with the controller and configured sterilize a battery contained within the dual-mode autoclave in response to a command from the controller. The environmental system configured to reduce a temperature of the battery to a first, pre-cooled temperature during a first operational phase and configured to increase the temperature of the battery to a second, autoclaving temperature during a second operational phase.

Abstract: An apparatus comprising a chamber where a base concentrate common to at least a first flavored food product and a second flavored food product is formed, the first flavored food product having different flavoring than the second flavored food product, the base concentrate having a first temperature. The apparatus also comprises a process line that receives the base concentrate from the chamber, heated liquid from a heated liquid source, and flavoring from either a first flavor source or a second flavor source to form a mixture of base concentrate, heated liquid and flavoring. The mixture has a has second temperature sufficient to achieve a change in the mixture selected from the group consisting of microbial change, chemical change, biochemical change, and enzymatic change, and combinations thereof. A method is also disclosed for change over from forming a first flavored food product to forming a second flavored food product.

Abstract: A steam generation system comprises: an oxygenated water treatment (OWT) sub-system configured to generate water having oxidizing chemistry; a steam generation sub-system configured to convert the water having oxidizing chemistry into steam having oxidizing chemistry; an attemperator or other injection device or devices configured to add an oxygen scavenger to the steam having oxidizing chemistry to generate steam having less oxidizing or reducing chemistry; and a condenser configured to condense the steam having less oxidizing or reducing chemistry into condensed water.

Abstract: The resonance chamber (1) has the form of an elongated closed shape. Microwave generators are fastened to the walls (1.1,1.2) of the chamber (1), their antennae (3,4) directed to the inside of the chamber (1). The microwave generators with antennae (3) are fastened to the chamber wall (1.1), while the microwave generators with antennae (4) are fastened to the wall (1.2) of the resonance chamber. The microwave generators on the wall (1.1) of the chamber are fastened so that in an orthogonal projection into the opposite wall of the chamber the antennae of two neighboring magnetrons are situated on the opposite sides of the product flow conduit (2). The antennae (3) of the successive magnetrons of the first series are situated alternately on the left and on the right side of the product flow conduit (2). Similarly distributed are the antennae (4) of the successive magnetrons of the second row.

Abstract: A method of decontaminating a freight container comprising the steps of: a) placing a freight container on a support; b) using an enclosure to substantially enclose the container on the support; and c) applying heat so that hot air moves within the enclosure around at least upright ends, sides and a roof of the container to kill or substantially weaken undesired life forms on or immediately adjacent to the exterior of the container.

Abstract: A method for disinfecting a microtome cryostat (1) comprises a defrosting phase (11), provision (13) of a vaporous disinfection agent (2) which acts upon the closed cryostat chamber (3) and a period of time (14) during which said disinfection agent (2) acts, and having an associated device for carrying out the method. According to the invention, fast and effective disinfection and rapid restarting of a microtome cryostat (1) is possible with secure drying, the temperature difference (?T1, ?T2) being produced after the period of time (14) in the cryostat chamber (3) whereupon the precipitated disinfection agent (2) is removed (18) to a cold area.

Abstract: The present invention refers to a method of processing a biological fluid which comprises cellular components by heat treatment. The method is particularly useful for preparing biological samples for analyte detection. Further, the invention refers to a processed biological fluid comprising substantially quantitatively disintegrated cellular components.

Abstract: The Furniture Pad Folding Machine is a dry cleaning machine that is multi-faceted; it can clean and disinfect furniture pads and the machine has the ability to fold furniture pads. The machine is portable and can function on the moving truck and at the warehouse.

Abstract: The invention relates to a sterilization coat (1) for sterilizing a device (2) like a medical detection device, wherein the sterilization coat (1) is adapted to be arranged on the device (2) and comprises a heating layer for sterilizing the device (2) by heating. If the sterilization coat (1) has been arranged on the device, several sterilization procedures can be performed by heating the sterilization coat (1) using the heating layer. Thus, it is not necessary to arrange sterile plastic drapes around the device (2) each time a sterile device is needed, for example, before each medical interventional procedure. If a sterilization of the device (2) is needed, the heating layer heats the device (2) for sterilizing. This simplifies the procedure for sterilizing the device (2).

Abstract: The present invention relates to a method for sterilizing an article inside a sealed container by placing a polyoxymethylene melt formable co-polymer that has been irradiated between about 1 and 200 kGy and then heated at from about 20° C. to about 90° C. for a selected period of time.

Abstract: By a method and a device for preventing corrosion on and in the region of a gas inlet nozzle during nitric acid condensation, contact of the condensing gas with the nozzle and with the surroundings of the nozzle are supposed to be minimized. This is achieved in that the gas inlet nozzle has a sleeve on the inside in the transition region to the interior of the condenser, by which sleeve a gas inlet orifice in the form of an annular gap is formed, whereby the annular space is provided with at least one feed opening for secondary air, so that an enveloping flow of secondary air is produced around the entering NO gas.

Abstract: The present invention relates to a cigar humidor, comprising: a hollow housing; a lid connected to the housing; a germicidal light assembly positioned inside the housing for disinfecting cigars; and a platform transparent to ultraviolet light produced by the assembly.

Abstract: A sterile enclosure contains a transfer module defining a window. A port covers the window to maintain the inside of the enclosure as a sealed and sterile environment. A sliding, heated cutting element mounted on the port serves to sterilize and sever a portion of a sterile transfer bag assembly attached to the port. Preferably, the excised portion of the sterile transfer bag assembly is affixed to the port when the port opens. The sliding cutting element remains extended and heated to prevent contamination when the port is open. Further, a heating element is mounted about the window in order to sterilize around the opening when the port is open.

Abstract: An apparatus comprising a chamber where a base concentrate common to at least a first flavored food product and a second flavored food product is formed, the first flavored food product having different flavoring than the second flavored food product, the base concentrate having a first temperature. The apparatus also comprises a process line that receives the base concentrate from the chamber, heated liquid from a heated liquid source, and flavoring from either a first flavor source or a second flavor source to form a mixture of base concentrate, heated liquid and flavoring. The mixture has a has second temperature sufficient to achieve a change in the mixture selected from the group consisting of microbial change, chemical change, biochemical change, and enzymatic change, and combinations thereof. A method is also disclosed for change over from forming a first flavored food product to forming a second flavored food product.