Device Having Torturous Path Patents (Class 422/414)
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Patent number: 12013396Abstract: Disclosed is a system and method for a microdevice to separate blood cells based on differences in antigen expression. Specifically, cells of the same phenotype are separated based on whether or not they are activated during infection or resting. The device of the present disclosure takes a small sample of blood and provides differential cell counts that can be used to test for infection and inflammatory response. The device can be used to identify sepsis and other infections rapidly. By measuring differences in activated white cell counts such as neutrophils, the device of the present disclosure measures physiological response to infection in hospitalized patients recovering from burns, surgeries, etc.Type: GrantFiled: July 29, 2020Date of Patent: June 18, 2024Assignee: Texas Tech Univeristy SystemInventor: Dimitri Pappas
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Patent number: 11476473Abstract: A reformer and an evaporator of a fuel cell module are provided adjacent to each other. An exhaust gas combustion chamber which combusts a fuel exhaust gas and an oxygen-containing exhaust gas discharged from a fuel cell to produce a combustion exhaust gas includes a first chamber and a second chamber connected to each other, and a combustion chamber outlet for discharging the combustion exhaust gas in the exhaust gas combustion chamber. At least part of an outer wall surface of the first chamber faces the evaporator with clearance. At least part of a wall forming the second chamber is a common wall shared with the reformer.Type: GrantFiled: July 30, 2020Date of Patent: October 18, 2022Assignee: HONDA MOTOR CO., LTD.Inventors: Hiroki Homma, Yuki Yoshimine, Yukihisa Kanao
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Patent number: 11362358Abstract: In a fuel cell module, a reformer and an evaporator provided adjacent to each other each extend to surround at least part of outer periphery of an exhaust gas combustion chamber as viewed in the direction of arrangement of the reformer and the evaporator. An auxiliary device case surrounds the outer periphery of the reformer and the evaporator with clearance. Both ends of the evaporator in the extension direction thereof are spaced from each other. The evaporator and the auxiliary device case are connected only by a first connector section at one position. The evaporator and the reformer are connected only by a second connector section at one position. Both ends of the reformer in the extension direction thereof are spaced from each other. The reformer and the auxiliary device case are connected only by a third connector section at one position.Type: GrantFiled: July 30, 2020Date of Patent: June 14, 2022Assignee: HONDA MOTOR CO., LTD.Inventor: Hiroki Homma
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Patent number: 11128316Abstract: Methods and apparatus for constructing polar codes are provided. A transmitter determines at least one set of parameters corresponding to data to be transmitted, and a set of sorting indices corresponding to bits of the data to be transmitted based on the set of parameters, the set of sorting indices indicating a position set of the bits to be transmitted. The transmitter polar encodes the data based at least on the set of parameters and the set of sorting indices to generate a coded block of the data, and transmits the coded block of the data.Type: GrantFiled: June 26, 2017Date of Patent: September 21, 2021Assignee: QUALCOMM IncorporatedInventors: Changlong Xu, Jian Li, Jilei Hou, Chao Wei
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Patent number: 9686395Abstract: A system, methods, and apparatus for biomolecular measurements, monitoring, and tracking uses a smartphone-based system. A biological sample, including, but not limited to blood, saliva, biopsy, or sweat, is collected on a modular diagnostic test platform, which is then inserted into a smartphone accessory. Optical, electrical, mechanical, or other means are used to transduce a biomolecular binding event, including antibody, aptamer, enzymatic, base-pair matching, or other biological recognition reaction and communicate the results with the smartphone. Some specific examples of targets include 25-hydroxyvitamin D, folic acid, DNA, or proteins from infectious agents, and zinc. The result can then be presented quantitatively or turned into a more consumer-friendly measurement (positive, negative, above average, etc.), displayed to the user, stored for later comparison, and communicated to a central hub location where medical professionals can provide additional review.Type: GrantFiled: September 6, 2013Date of Patent: June 20, 2017Assignee: CORNELL UNIVERSITYInventors: David Erickson, Matthew Mancuso, Seoho Lee
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Patent number: 8932538Abstract: A apparatus for analyzing sample to prevent a sample from being stuck to a surface of the apparatus for analyzing sample in the course of being injected into the apparatus for analyzing sample. The apparatus for analyzing sample includes a platform having a disk shape. The platform includes chambers and channels, a sample inlet hole which is formed in an outer surface the platform and through which a sample is injected into the platform; an opening which is formed in the outer surface of the platform and through which a residual of the sample, present on the outer surface of the platform around the sample inlet hole, is introduced into a receiving space isolated from the chambers and channels; and a barrier which is formed on the outer surface of the platform around a portion of the opening to prevent the residual of the sample from moving past the opening in a radial outward direction of the platform.Type: GrantFiled: January 14, 2011Date of Patent: January 13, 2015Assignee: Samsung Electronics Co., Ltd.Inventors: Hyun Min Kim, Do Gyoon Kim, Jong Myeon Park
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Patent number: 8920748Abstract: The present invention relates to a biochip with a piezoelectric element for ultrasonic standing wave generation. The biochip comprises an upper module, a lower module, and a chemical sensor. The piezoelectric element is integrated within the upper module of the biochip. The piezoelectric element can generate ultrasonic standing waves (USW) in the reaction chamber of the biochip by manipulating the operation frequency so the particles being detected can effectively move toward the QCM sensing surface. Hence, the biochip significantly increases the sensitivity and reduces the time required to reach equilibrium when undergoing USW excitation. The biochip of the present invention can be broadly applied to the bio-detection in medical and pharmaceutical fields.Type: GrantFiled: May 2, 2011Date of Patent: December 30, 2014Assignee: National Chung Cheng UniversityInventors: Guo-Hua Feng, Lai-Kwan Chau, Shu-Xiang Yang
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Patent number: 8790916Abstract: The invention relates to a system and method for isolating particles from a biological fluid, including: obtaining a sample of biological fluid from a source (e.g. a patient) in which the sample contains particles of multiple sample particle types; tagging particles in the sample with tagging agents, including mixing the sample with a solution of magnetic tagging agents that selectively bind to particles of at least one of the sample particle types, thereby forming a group of tagged particles in the sample; passing the sample through a magnetic conduit having a magnetic field that interacts with at least some of the tagged particles; sorting the particles of the sample into multiple groups based on the interaction between the tagged particles and the magnetic field; and optionally returning selected portions of the processed fluid back to its source with or without the addition of appropriate therapeutic agents.Type: GrantFiled: May 13, 2010Date of Patent: July 29, 2014Assignee: GeneStream, Inc.Inventors: Achal Singh Achrol, Palaniappan Sethu
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Patent number: 8697435Abstract: A system for sample preparation and analyte detection includes a cartridge, with a fluidic channel, a waveguide, and a capture spot. The system further includes a force field generator, an imaging system, and a fluid, which includes a sample potentially containing a target analyte, first type particles, which include binding moieties specific for the target analyte and are responsive to a force field, and second type particles, which include binding moieties specific for the target analyte and are capable of generating a signal. When the sample contains the target analyte, specific binding interactions between the target analyte and binding moieties link first and second type particles via the target analyte to form multiple-particle complex capturable at a capture spot. The force field allows manipulation of the particles and multiple-particle complex such that the detected signal from the second type particles is indicative of the target analyte within the sample.Type: GrantFiled: August 30, 2010Date of Patent: April 15, 2014Assignee: MBio Diagnostics, Inc.Inventors: James R. Heil, Michael J. Lochhead, Kevin D. Moll, Christopher J. Myatt
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Patent number: 8633013Abstract: A method for assaying a sample for each of multiple analytes is described. The method includes contacting an array of spaced-apart test zones with a liquid sample (e.g., whole blood). The test zones disposed within a channel of a microfluidic device. The channel is defined by at least one flexible wall and a second wall which may or may not be flexible. Each test zone comprising a probe compound specific for a respective target analyte. The microfluidic device is compressed to reduce the thickness of the channel, which is the distance between the inner surfaces of the walls within the channel. The presence of each analyte is determined by optically detecting an interaction at each of multiple test zones for which the distance between the inner surfaces at the corresponding location is reduced. The interaction at each test zone is indicative of the presence in the sample of a target analyte.Type: GrantFiled: May 5, 2008Date of Patent: January 21, 2014Assignee: Clondiag GmbHInventors: Thomas Kaiser, Klaus-Peter Möbius, Torsten Schulz, Thomas Uhlig, Alexander Von Schenk Zu Schweinsberg, Eugen Ermantraut, Jens Tuchscheerer
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Patent number: 8603835Abstract: Test cells have a first sorbent strip with a sample receiving location and defining a first migration path, a distinct second sorbent strip which receives buffer solution and at least partially defines a second migration path distinct from and elongated relative to the first migration path, conjugate supported by the second strip, a test site located at a junction of the first and second strips and having an immobilized ligand-binding mechanism, and a divider which directs a first amount of the buffer to the first strip to move the sample to the test site and a second amount to the second strip to move the conjugate to the test site. The first and second migration paths have first and second lengths chosen so that ligand in the sample reaches the test site and binds to the immobilized ligand-binding mechanism prior to the conjugate reaching the test site.Type: GrantFiled: February 10, 2011Date of Patent: December 10, 2013Assignee: Chembio Diagnostic Systems, Inc.Inventor: Javanbakhsh Esfandiari
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Patent number: 8470588Abstract: A test element and method for detecting an analyte with the aid thereof is provided. The test element is essentially disk-shaped and flat, and can be rotated about a preferably central axis which is perpendicular to the plane of the disk-shaped test element. The test element has a sample application opening for applying a liquid sample, a capillary-active zone, in particular a porous, absorbent matrix, having a first end that is remote from the axis and a second end that is near to the axis, and a sample channel which extends from an area near to the axis to the first end of the capillary-active zone that is remote from the axis.Type: GrantFiled: March 19, 2009Date of Patent: June 25, 2013Assignee: Roche Diagnostics Operations, Inc.Inventors: Christoph Boehm, Norbert Oranth, Juergen Spinke
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Patent number: 8394626Abstract: The present invention includes but is not limited to a specimen collection device that includes a chamber capable of collecting a specimen, a specimen passage slot, a reservoir, a reservoir seal, and a test device. A sample or specimen added to the chamber flows through the specimen passage slot into the reservoir. Flow into the reservoir may be limited by the reservoir seal. The test device positioned within the reservoir detects the presence or concentration of an analyte within the sample or specimen.Type: GrantFiled: June 2, 2009Date of Patent: March 12, 2013Assignee: Alere Switzerland GmbHInventors: James T. Ramsey, Larry Hartselle
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Patent number: 8357083Abstract: The present invention provides a sterilization confirmation tester and a test pack which enables effective sterilization to be confirmed in a simple and sure manner by providing a simulation of the structure of an endoscope and so forth. The sterilization confirmation tester according to the present invention has a function of confirming effective sterilization treatment after sterilization performed by a sterilization apparatus. The sterilization confirmation tester includes a structure corresponding to at least one of the components which form the endoscope.Type: GrantFiled: April 25, 2011Date of Patent: January 22, 2013Assignee: Olympus CorporationInventors: Yuki Nagai, Maiko Shiga, Yosuke Kanamori, Sawako Sato, Kaori Obi
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Patent number: 8343526Abstract: Disclosed are methods for conducting assays of samples, such as whole blood, that may contain cells or other particulate matter. Also disclosed are systems, devices, equipment, kits and reagents for use in such methods. One advantage of certain disclosed methods and systems is the ability to rapidly measure the concentration of an analyte of interest in blood plasma from a whole blood sample without blood separation and hematocrit correction.Type: GrantFiled: October 18, 2011Date of Patent: January 1, 2013Assignee: Meso Scale Technologies, LLCInventors: Mark A. Billadeau, Jeff D. Debad, Eli N. Glezer, Jonathan K. Leland, Charles A. Wijayawardhana
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Patent number: 8337775Abstract: A micro-liter liquid sample, particularly a biological sample, is analyzed in a device employing centrifugal and capillary forces. The sample is moved through one or more sample wells arrayed within a small flat chip via interconnecting capillary passageways. The passageways may be either hydrophobic or hydrophilic and may include hydrophobic or hydrophilic capillary stops.Type: GrantFiled: September 8, 2008Date of Patent: December 25, 2012Assignee: Siemens Healthcare Diagnostics, Inc.Inventors: Michael J. Pugia, Gert Blankenstein, Ralf-Peter Peters, Holger Bartos
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Patent number: 8333934Abstract: The present invention relates to a device for interfacing nanofluidic and microfluidic components suitable for use in performing high throughput macromolecular analysis. Diffraction gradient lithography (DGL) is used to form a gradient interface between a microfluidic area and a nanofluidic area. The gradient interface area reduces the local entropic barrier to nanochannels formed in the nanofluidic area. In one embodiment, the gradient interface area is formed of lateral spatial gradient structures for narrowing the cross section of a value from the micron to the nanometer length scale. In another embodiment, the gradient interface area is formed of a vertical sloped gradient structure. Additionally, the gradient structure can provide both a lateral and vertical gradient.Type: GrantFiled: September 28, 2006Date of Patent: December 18, 2012Assignee: Princeton UniversityInventors: Han Cao, Jonas O. Tegenfeldt, Stephen Chou, Robert H. Austin
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Patent number: 8309366Abstract: Methods and devices for rapid lateral flow immunoassays to detect specific antibodies within a liquid sample while also validating the adequacy of the liquid sample for the presence of immunoglobulin and the integrity and immunoreactivity of the test reagents that detect the antibodies of interest, without requiring instrumentation. The methods and devices provide for delivery of a diluted liquid sample to a single location that simultaneously directs the liquid flow along two or more separate flow paths, one that serves as a positive control to confirm that all critical reagents of the test are immunoreactive, and that the sample being tested is adequate, and the other to detect specific antibodies if present.Type: GrantFiled: December 23, 2011Date of Patent: November 13, 2012Inventor: Thomas M. Buchanan
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Patent number: 8304230Abstract: The invention features methods for separating cells from a sample (e.g., separating fetal red blood cells from maternal blood). The method begins with the introduction of a sample including cells into one or more microfluidic channels. In one embodiment, the device includes at least two processing steps. For example, a mixture of cells is introduced into a microfluidic channel that selectively allows the passage of a desired type of cell, and the population of cells enriched in the desired type is then introduced into a second microfluidic channel that allows the passage of the desired cell to produce a population of cells further enriched in the desired type. The selection of cells is based on a property of the cells in the mixture, for example, size, shape, deformability, surface characteristics (e.g., cell surface receptors or antigens and membrane permeability), or intracellular properties (e.g., expression of a particular enzyme).Type: GrantFiled: March 21, 2007Date of Patent: November 6, 2012Assignee: The General Hospital CorporationInventors: Mehmet Toner, George Truskey, Ravi Kapur
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Patent number: 8273566Abstract: Disclosed are methods for conducting assays of samples, such as whole blood, that may contain cells or other particulate matter. Also disclosed are systems, devices, equipment, kits and reagents for use in such methods. One advantage of certain disclosed methods and systems is the ability to rapidly measure the concentration of an analyte of interest in blood plasma from a whole blood sample without blood separation and hematocrit correction.Type: GrantFiled: July 6, 2010Date of Patent: September 25, 2012Assignee: Meso Scale Technologies, LLCInventors: Mark A. Billadeau, Jeff D. Debad, Eli N. Glezer, Jonathan K. Leland, Charles A. Wijayawardhana
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Patent number: 8226904Abstract: Formats for optical analysis of fluid samples are provided with platforms and wells for contacting fluid samples and bringing reagents in contact with fluid samples. Formats may be made in opposing platform-and-well constructions, allowing a platform protruding from one format member to enter a well contained within an opposing format member. A sample fill nose accepts sample fluid from a sample collection opening and transports the sample fluid through the format.Type: GrantFiled: October 29, 2004Date of Patent: July 24, 2012Assignee: Bayer Healthcare LLCInventor: Andrew J. Dosmann
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Patent number: 8067226Abstract: The invention is directed to a method and device for simultaneously testing a sample for the presence, absence, and/or amounts of one or more of a plurality of selected analytes. The invention includes, in one aspect, a device for detecting or quantitating a plurality of different analytes in a liquid sample. Each chamber may include an analyte-specific reagent effective to react with a selected analyte that may be present in the sample, and detection means for detecting the signal. Also disclosed are methods utilizing the device.Type: GrantFiled: May 10, 2006Date of Patent: November 29, 2011Assignee: Applied Biosystems, LLCInventors: Timothy M. Woudenberg, Michael Albin, Reid B. Kowallis, Yefim Raysberg, Robert P. Ragusa, Emily S. Winn-Deen
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Patent number: 8062883Abstract: The invention is directed to a method and device for simultaneously testing a sample for the presence, absence, and/or amounts of one or more a plurality of selected analytes. The invention includes, in one aspect, a device for detecting or quantitating a plurality of different analytes in a liquid sample. The device includes a substrate which defines a sample-distribution network having (i) a sample inlet, (ii) one or more detection chambers, and (iii) channel means providing a dead-end fluid connection between each of the chambers and the inlet Each chamber may include an analyte-specific reagent effective to react with a selected analyte that may be present in the sample, and detection means for detecting the signal. Also disclosed are methods utilizing the device.Type: GrantFiled: January 9, 2007Date of Patent: November 22, 2011Assignee: Applied Biosystems, LLCInventors: Timothy Woudenberg, Michael Albin, Reid B. Kowallis, Yefim Raysberg, Robert P. Ragusa, Emily S. Winn-Deen
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Patent number: 8021625Abstract: A device and method for enhancing rapid confirmatory immunological testing (“RCIT”) in chromatography strip-type rapid IVD devices useful in, for example, clinical, point-of-care, laboratory or over-the-counter settings. The device drives a flow fluid, primarily under the force of gravity alone, through a first chamber having a porous dam structure to enhance and substantially complete the first affinity binding reaction between a source of mobilizable labeled binding members and an analyte in the fluid. Flow through the dam causes a delay, mixing and trapping of the typically chemically disuniform initial fluid front so that fluid exiting the dam exhibits a more uniformly high degree of first affinity binding and decreased non-affinity binding.Type: GrantFiled: July 27, 2007Date of Patent: September 20, 2011Assignee: DNT Scientific Research, LLCInventors: Naishu Wang, David F. Zhou
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Patent number: 7981689Abstract: An absorption spectrometric analysis microchip with a chamber for holding a sample, a chamber for holding a reagent which reacts with this sample, a mixing chamber for mixing the reagent with the sample with the formation of a mixture and a sensing part with a sensing chamber for holding the mixture with a light incidence surface for the entry of light into the sensing chamber and a light exit surface for emergence of light from the sensing chamber. At least one of the light incidence surface and light exit surface is located in a recess area of the sensing part.Type: GrantFiled: September 14, 2005Date of Patent: July 19, 2011Assignee: Rohm Co., Ltd.Inventors: Shigeki Matsumoto, Shigenori Nozawa
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Patent number: 7927866Abstract: A process challenge device (PCD) for determining the effectiveness of a microbial deactivation process that uses a vaporous deactivating agent (e.g., vaporized hydrogen peroxide) as a deactivating agent. The PCD includes first and second layers that are joined together to form (1) a chamber dimensioned to receive a biological and/or chemical indicator, and (2) first and second conduits fluidly connecting the chamber with a region outside the PCD. Each conduit has one end in communication with the region outside the PCD and another end in communication with the chamber. A removable seal member seals the biological and/or chemical indicator inside the chamber.Type: GrantFiled: April 19, 2007Date of Patent: April 19, 2011Assignee: American Sterilizer CompanyInventors: Christopher J. Justi, Susan G. Quick, Michael M. Tsentr
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Patent number: 7067561Abstract: Fischer-Tropsch synthesis is performed on a CO/H*2 feed gas using a plurality of compact catalytic reactor modules (12) each defining catalytic reaction channels and coolant channels, in two successive stages, with the same number of reactor modules for each stage. The gas flow velocity in the first stage is sufficiently high that no more than 75% of the CO undergoes conversion. The gases are cooled (16) between successive stages so as to remove water vapour, and the pressure is reduced (20) before they are subjected to the second stage. In addition the reaction temperature for the second stage is lower than for the first stage, such that no more than 75% of the remaining carbon monoxide undergoes conversion during the second stage too. The deleterious effect of water vapour on the catalyst is hence suppressed, while the overall capacity of the plant (10) can be adjusted by closing off modules in each stage while keeping the numbers equal.Type: GrantFiled: June 1, 2005Date of Patent: June 27, 2006Assignee: GTL Microsystems AGInventor: Michael Joseph Bowe