Plural Layers Patents (Class 422/421)
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Patent number: 8673237Abstract: The invention relates to a sensor having a color-changeable sensory surface, characterized in that at least one molecular layer of a positively charged polymer (4) is bonded to a further molecular layer of a negatively charged polymer (5) in alternation by means of ionic forces, wherein a solvent is stored in the charged polymer layers (4, 5), whereby the polymer layers swell at least 10%, and colored, preferably metal or semiconducting nanoparticles (6) are bonded to the last charged polymer molecular layer, and the total layer thickness of the inert intermediate layer (3) and all polymer layers (4, 5) is at least 40 nm but less than 500 nm so that the layer setup has an interference color that is visible to the human eye or measurable in the infrared and that can be changed by means of interaction with an analyte, the interference color being caused by optical interference between the material surface (2) and the layer of the nanoparticles (6).Type: GrantFiled: August 5, 2010Date of Patent: March 18, 2014Inventor: Thomas Schalkhammer
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Publication number: 20140065606Abstract: A single device to collect, transfer, and measure salivary nitric oxide analyte and metabolite, nitrite, a biomarker for nitric oxide, as well as, a method to assess the effects of diet and exercise on changing an individual's nitric oxide status and health.Type: ApplicationFiled: September 6, 2013Publication date: March 6, 2014Applicant: Berkeley Test, LLCInventors: Natalie Green, Juliana Green
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Publication number: 20140065030Abstract: The present invention is directed toward a colorimetric detection kit comprising a unit containing chemical reagents and a sample collector for collecting a sample analyte from a surface and a separate unit for visualizing a possible reaction of the chemical reagent and sample, the unit holding the chemical reagents and sample collector being placeable on the visualization unit, whereby when the chemical reagents are released, they are directed onto the sample collector for reaction and the reacted reagents absorbed on a visualization media, such that the presence of a specified analyte in the sample results in a color change in the visualization media.Type: ApplicationFiled: October 23, 2012Publication date: March 6, 2014Applicant: U.S. Army Research Development and Engineering CommandInventor: U.S. Army Research Development and Engineerin
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Patent number: 8663563Abstract: A reflective diffractometric hydrogel sensor includes an upper layer, including a microfluidic chamber formed from a substantially transparent material and configured to contain a solution, a reflective diffraction grating positioned within the microfluidic chamber, the diffraction grating including a plurality of hydrogel strips configured to change in dimension in response to a stimulus, each hydrogel strip having a top surface coated with a reflective material and a bottom surface in contact with the upper layer substrate, and a reflective surface below the reflective diffraction grating wherein when a coherent light is incident upon and reflected from the upper layer at an angle substantially normal to the upper layer an interference diffraction pattern results, including a first diffraction mode, a light intensity of which indicates the relative distance between the top surfaces of the plurality of hydrogel strips and the reflective surface.Type: GrantFiled: December 5, 2011Date of Patent: March 4, 2014Assignees: Purdue Research Foundation, Board of Regents, The University of Texas SystemInventors: Cagri Savran, Chun-Li Chang, Zhenwen Ding, Babak Ziaie, Andrew Ellington, Venkata Naga Lakshmi Rekha Patchigolla
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Patent number: 8663578Abstract: A liquid droplet introducing tank 3A includes a tank body 31, which is formed by mutually opposing top surface 31a and bottom surface 31b, and a side surface 31c. The tank also includes an injection hole 32 that is opened in the top surface 31a. Liquid droplets Dr are injected from the injection hole 32. The center of the injection hole 32 is closer to the side surface 31c than the center of the top surface 31a. The liquid droplet introducing tank 3A enables liquid droplets to be suitably injected therein and is suitable for reducing size.Type: GrantFiled: March 30, 2009Date of Patent: March 4, 2014Assignee: ARKRAY, Inc.Inventor: Yukihiro Sukawa
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Patent number: 8647575Abstract: A blood glucose meter includes a front attachment part to which a test piece is attached, a measurement part for measuring a component of blood collected via a blood guide passage in the test piece, and a monitor for displaying the measurement results obtained by the measurement part. When the device is placed on a horizontal plane by referring to the display face of the monitor as the upper side and the opposite side as the lower side and placing the display face of the monitor upward, the central axis of the test piece extends obliquely downward toward the front side. The blood glucose meter comprises a main part provided with the monitor and a linking part between the main part and the front attachment part. The top face of the linking part is placed roughly parallel to the central axis line and is provided with an ejector lever.Type: GrantFiled: November 19, 2009Date of Patent: February 11, 2014Assignee: Terumo Kabushiki KaishaInventor: Hirotaka Ohashi
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Patent number: 8647589Abstract: An object of the invention is to provide various flow cells and a method for manufacturing the same, in which formation of a groove on a substrate and formation of components such as an electrode, auxiliary parts such as a pump are not necessary. The inventive flow cells are capable of realize complicated chemical analysis or synthesis or the like. A channel of a porous member provided on a sample-incompatible substrate is formed; the porous member is composed of an air non-contact region having a network structure and an air contact region covering the air non-contact region and having a lower pore density than the air non-contact region; in which a capillary force to be generated within the porous member is a drive force for pumping a liquid.Type: GrantFiled: July 20, 2012Date of Patent: February 11, 2014Assignee: Nippon Telegraph and Telephone CorporationInventors: Tsutomu Horiuchi, Toru Miura, Yuzuru Iwasaki, Jyunichi Takahashi, Katsuyoshi Hayashi, Tsuneyuki Haga, Michiko Seyama, Serge Camou
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Patent number: 8632730Abstract: In one aspect, a diagnostic test system includes a receptacle, optical detectors, and a logic circuit. Each of the optical detectors has a corresponding view in the receptacle and produces an electrical signal at a respective detector output in response to light from the corresponding view. The logic circuit includes logic inputs that are respectively coupled to the detector outputs and that produce an output logic signal corresponding to a logical combination of signals received at the logic inputs. In another aspect, respective detection signals are produced in response to light received from respective ones of multiple views of the test strip, and at least one output logic signal corresponding to a respective logical combination of the detection signals is generated.Type: GrantFiled: November 22, 2005Date of Patent: January 21, 2014Assignee: Alverix, Inc.Inventors: John F. Petrilla, Daniel B. Roitman
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Patent number: 8580201Abstract: Embodiments of the present invention include processing steps and subsystems, within automated-biopolymer-synthesis systems and within other automated systems for organic-chemistry-based processing, for removing reagent solutions and solvents from reaction chambers following various synthetic reaction steps and washing steps undertaken during biopolymer synthesis. Embodiments of the present invention employ any of various different types of liquid-absorbing materials to wick, or remove by capillary action, liquids from reaction chambers. Wicking-based methods and subcomponents of the present invention remove significantly greater fractions of solutions from reaction chambers than conventional methods and subsystems and, in addition, are mechanically simpler and produce fewer deleterious side effects than currently used methods and subsystems.Type: GrantFiled: February 22, 2011Date of Patent: November 12, 2013Assignee: OligoCo, Inc.Inventors: Hsing-Yeh Parker, John C. Tabone, John Mulligan
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Patent number: 8580572Abstract: The invention relates to a lateral flow assay test strip and a method for making the same. The strip comprises, in the flow direction, a selectively activated membrane for a test reaction and an absorption pad, which are both made of paper and may comprise an integral paper strip. The absorption pad has the paper strip embossed and/or folded to increase the strip's absorption capacity. The folded pad may have an accordion-like configuration, the strip running to-and-from, or it may have the strip rolled and then flattened to a stack of layers.Type: GrantFiled: May 3, 2010Date of Patent: November 12, 2013Assignee: Teknologian TutkimuskeskusInventor: Timo Lappalainen
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Patent number: 8557195Abstract: A sensor substrate includes a base and fibrous projections on an upper surface of the base. The fibrous projections have fixed ends fixed to the upper surface of the base and free ends opposite to the fixed ends, respectively. The fibrous projections provide a fixed end-side region including the fixed ends and a free end-side region including the free ends. The total surface area at which the fibrous projections in the fixed end-side region is larger than that in the free end-side region.Type: GrantFiled: September 14, 2012Date of Patent: October 15, 2013Assignee: Panasonic CorporationInventors: Masaya Nakatani, Makoto Takahashi, Takuya Oka
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Patent number: 8551420Abstract: Provided is a water absorbing material having a granular core portion and a coating layer portion coating the granular core portion, which does not produce color before use and with which a test result can be determined only after use. In the water absorbing material, the coating layer portion is composed of 90 wt % to 96 wt % of a substrate and 10 wt % to 4 wt % of an excretion test material, the excretion test material contains a porous adsorbent having an adsorbance of 25 wt % or greater and including micropores, and an excretion test indicator adsorbed on the micropores of the porous adsorbent, and the excretion test indicator is added in an amount in the range of 0.015 wt % to 0.10 wt % relative to the total amount of the coating layer portion.Type: GrantFiled: May 22, 2012Date of Patent: October 8, 2013Assignee: Daiki Co., Ltd.Inventors: Hiroshi Ito, Shinobu Hatanaka, Takahiro Hosoya
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Patent number: 8540945Abstract: Provided is a water absorbing material having a granular core portion and a coating layer portion coating the granular core portion, which does not produce color before use and with which a test result can be determined only after use. In the water absorbing material, the coating layer portion is composed of 90 wt % to 96 wt % of a substrate and 10 wt % to 4 wt % of an excretion test material, the excretion test material contains a porous adsorbent having an adsorbance of 25 wt % or greater and including micropores, and an excretion test indicator adsorbed on the micropores of the porous adsorbent, and the excretion test indicator is added in an amount in the range of 0.015 wt % to 0.10 wt % relative to the total amount of the coating layer portion.Type: GrantFiled: October 1, 2012Date of Patent: September 24, 2013Assignee: Daiki Co., Ltd.Inventors: Hiroshi Ito, Shinobu Hatanaka, Takahiro Hosoya
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Patent number: 8535617Abstract: A lateral flow device for analyzing a whole blood sample is provided. More specifically, the lateral flow device contains a porous membrane that defines a barrier zone for separating red blood cells from blood plasma (includes plasma in which clotting factors haven been removed), which may then flow to a subsequent detection zone for analysis. The barrier zone is formed from a blood cell barrier composition that includes an unsaturated aliphatic fatty acid or an ester thereof. Without intending to be limited by theory, the present inventors believe such unsaturated aliphatic fatty acid molecules undergo autoxidation in the presence of air and hemoglobin to release peroxides (e.g., hydrogen peroxide) via oxidative saturation of double bonds. In turn, the released peroxides are believed to induce the formation of echinocytes or crenated blood cells.Type: GrantFiled: November 30, 2007Date of Patent: September 17, 2013Assignee: Kimberly-Clark Worldwide, Inc.Inventors: J. Gavin MacDonald, Molly K. Smith
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Patent number: 8518342Abstract: The present invention relates generally to the field of analysis, for example biological analysis.Type: GrantFiled: June 24, 2005Date of Patent: August 27, 2013Assignee: BiomerieuxInventors: David Mosticone, Pascal Montes, Jean-Claude Raymond, Bruno Colin, Cecile Paris
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Patent number: 8507260Abstract: Disclosed is a lateral flow capillary device and uses thereof comprising a unipath bibulous capillary flow matrix and at least two reservoirs each in fluid communication with the capillary flow matrix wherein a reservoir contacts the capillary flow matrix through a passage having a rim pressing the matrix. The pressure that the rim applies on the matrix prevents leakage of liquids out of the capillary flow matrix at the reservoir/ matrix interface, allowing accurate sequential draining of liquid from the reservoirs.Type: GrantFiled: June 2, 2010Date of Patent: August 13, 2013Assignee: Realbio Technologies, Ltd.Inventors: Sara Alajem, Avraham Reinhartz
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Patent number: 8506902Abstract: Colorimetric sensor films comprising a reflective layer, a polymeric detection layer, and a semi-reflective layer are disclosed. Devices comprising the calorimetric sensor films and methods of making the films and devices are also disclosed.Type: GrantFiled: October 2, 2008Date of Patent: August 13, 2013Assignee: 3M Innovative Properties CompanyInventors: Neal A. Rakow, Christopher S. Lyons, Stephen P. Maki
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Patent number: 8506903Abstract: According to one embodiment of the present invention, an optical-based test sensor for use in the determination of an analyte in a liquid sample is disclosed. The test sensor includes a base, a polymer carrier, and a test membrane. The base has a capillary channel formed in a surface of the base that is adapted to move a liquid sample from an inlet to a reaction area formed in the base. The polymer carrier has a lower surface adhered to the surface of the base and is disposed over at least a portion of the capillary channel. The test membrane, which contains a reagent, is adhered to the lower surface of the polymer carrier and extends from the polymer carrier into the reaction area.Type: GrantFiled: March 9, 2012Date of Patent: August 13, 2013Assignee: Bayer HealthCare LLCInventor: Rex J. Kuriger
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Patent number: 8491851Abstract: A detection system in a portable assay reader device is enabled or activated after a user applies a manual force to a portion of the reader device, to an object supporting the assay test strip, or to the assay test strip itself. The movement moves a switch from an open state to a closed state. The closed state enables a detection system to monitor one or more test regions in the assay test strip for a reaction. The detection system can include one or more imagers, one or more electrical detectors, one or more magnetic detectors, or one or more optical detectors that monitor the one or more test regions for applicable visible, electrical, magnetic, or optical reactions, respectively. The one or more imagers or detectors transmit data to a processing device to determine the results of a test.Type: GrantFiled: November 30, 2006Date of Patent: July 23, 2013Assignee: Alverix, Inc.Inventors: Brenton A. Baugh, Robert Sean Murphy
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Patent number: 8476082Abstract: Devices and methods for the detection of target molecules are disclosed. Devices and methods for detecting food-borne target molecules are also disclosed.Type: GrantFiled: April 12, 2012Date of Patent: July 2, 2013Assignee: Invisible Sentinel, Inc.Inventors: Nicholas A. Siciliano, Martin Joseph Bouliane
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Patent number: 8460863Abstract: A method of preparing a dry stick test device for determining an analyte in a milk sample by chemical assay. At least one reagent pad is provided by impregnating a first porous material with an aqueous solution including a reagent capable of reacting with the analyte, a derivative of the analyte or an indicator compound for the analyte to provide a detectable signal when in a moistened state. The reagent pad is dried. A development pad is provided by impregnating a second porous material with an aqueous solution including at least one controlling compound which, when in a moistened state, is capable of providing a condition required for the reagent to react with the analyte to provide the detectable signal. The impregnated second porous material is dried. The first porous material is immobilized with the second porous material, on a solid support, to obtain the dry stick test device.Type: GrantFiled: June 11, 2012Date of Patent: June 11, 2013Assignee: Lattec I/SInventor: Lars Nygaard
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Patent number: 8460619Abstract: An apparatus for processing a specimen from a fluid sample includes a first set of one or more microfluidic channels configured to deliver the sample fluid to a filter disposed on an inflatable bladder configured to transfer the specimen from the filter to a slide. The apparatus is configured to collect an approximate monolayer of particles and includes a second set of one or more microfluidic channels configured to remove fluid flowing through the filter disposed on the inflatable bladder. The apparatus also includes a pressure source, a sample container connected to the pressure source and the first set of one or more microfluidic channels, a fluid flow gauge configured to measure a fluid flow rate through the filter, and a stain source connected to the first set of one or more microfluidic channels.Type: GrantFiled: October 6, 2009Date of Patent: June 11, 2013Assignee: CYTYC CorporationInventors: Howard B. Kaufman, Tuan Ha
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Patent number: 8454903Abstract: Disclosed is an assay device comprising liquid transport means adapted to take up a liquid sample and conduct the liquid to an analyte detection region operable to provide a test signal indicative of the presence and/or amount of an analyte in the liquid sample; the assay device further comprising a sample presence signal generation means, which is not generated by means of an immunoreaction. This sample presence signal generation means can comprise a colored portion, which is overlaid by a material (e.g. nitrocellulose) that is opaque, when dry, and translucent or transparent, when wet, to allow the colored portion to become visible to the user. In another embodiment the signal generation means comprises a color changing material which under-goes a change in its visible properties upon wetting (eg. pH indication). A third embodiment uses a mobilisable detectable which, when wetted by the sample, is carried along resulting in a streaked line parallel with the flow direction.Type: GrantFiled: June 26, 2003Date of Patent: June 4, 2013Assignee: Alere Switzerland GmbHInventors: Barry Sinclair Brewster, Adrian Leslie Walker, Robert John Davies
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Patent number: 8449834Abstract: The present disclosure relates to a carbon dioxide detector having a borosilicate substrate. It may also have a carbon dioxide responsive indicator solution disposed on the borosilicate substrate. The carbon dioxide detector may be part of a carbon dioxide detector system also including an air intake operably connected to the housing to allow air to reach the carbon dioxide detector. The carbon dioxide detector may include a borosilicate substrate and a carbon dioxide responsive indicator solution disposed on the borosilicate substrate. This detector may be part of a further system, such as a resuscitation system. The detector may be made by wetting a borosilicate substrate with a carbon dioxide responsive indicator solution and drying the indicator solution to immobilize it and form a dried carbon dioxide detector. It may be used to detect the concentration of carbon dioxide in an air sample by exposing the detector to the sample.Type: GrantFiled: September 25, 2006Date of Patent: May 28, 2013Assignee: Covidien LPInventors: Rafael Ostrowski, Martin Debreczeny
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Patent number: 8449832Abstract: A test sensor includes a base, a lid and a channel for receiving a fluid sample. The channel includes a reagent. The test sensor also includes a tip portion extending from at least one of the base and lid. The tip portion prevents or inhibits moisture or contaminants from entering the channel and affecting the reagent. The test sensor further includes a detachable area located adjacent the tip portion. The detachable area is formed so as to assist movement of the tip portion or removal of the tip portion from the remainder of the test sensor. The movement or removal of the tip portion exposes the channel for receiving the fluid sample.Type: GrantFiled: December 8, 2008Date of Patent: May 28, 2013Assignee: Bayer HealthCare, LLCInventor: Simin Yao
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Patent number: 8431087Abstract: The present disclosure relates to a carbon dioxide detector having a borosilicate substrate. It may also have a carbon dioxide responsive indicator solution disposed on the borosilicate substrate. The carbon dioxide detector may be part of a carbon dioxide detector system also including an air intake operably connected to the housing to allow air to reach the carbon dioxide detector. The carbon dioxide detector may include a borosilicate substrate and a carbon dioxide responsive indicator solution disposed on the borosilicate substrate. This detector may be part of a further system, such as a resuscitation system. The detector may be made by wetting a borosilicate substrate with a carbon dioxide responsive indicator solution and drying the indicator solution to immobilize it and form a dried carbon dioxide detector. It may be used to detect the concentration of carbon dioxide in an air sample by exposing the detector to the sample.Type: GrantFiled: September 25, 2006Date of Patent: April 30, 2013Assignee: Covidien LPInventors: Rafael Ostrowski, Martin Debreczeny
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Patent number: 8431088Abstract: The present disclosure relates to a carbon dioxide detector having a borosilicate substrate. It may also have a carbon dioxide responsive indicator solution disposed on the borosilicate substrate. The carbon dioxide detector may be part of a carbon dioxide detector system also including an air intake operably connected to the housing to allow air to reach the carbon dioxide detector. The carbon dioxide detector may include a borosilicate substrate and a carbon dioxide responsive indicator solution disposed on the borosilicate substrate. This detector may be part of a further system, such as a resuscitation system. The detector may be made by wetting a borosilicate substrate with a carbon dioxide responsive indicator solution and drying the indicator solution to immobilize it and form a dried carbon dioxide detector. It may be used to detect the concentration of carbon dioxide in an air sample by exposing the detector to the sample.Type: GrantFiled: September 25, 2006Date of Patent: April 30, 2013Assignee: Covidien LPInventors: Rafael Ostrowski, Martin Debreczeny
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Patent number: 8420405Abstract: The present disclosure relates to a carbon dioxide detector having a borosilicate substrate. It may also have a carbon dioxide responsive indicator solution disposed on the borosilicate substrate. The carbon dioxide detector may be part of a carbon dioxide detector system also including an air intake operably connected to the housing to allow air to reach the carbon dioxide detector. The carbon dioxide detector may include a borosilicate substrate and a carbon dioxide responsive indicator solution disposed on the borosilicate substrate. This detector may be part of a further system, such as a resuscitation system. The detector may be made by wetting a borosilicate substrate with a carbon dioxide responsive indicator solution and drying the indicator solution to immobilize it and form a dried carbon dioxide detector. It may be used to detect the concentration of carbon dioxide in an air sample by exposing the detector to the sample.Type: GrantFiled: September 25, 2006Date of Patent: April 16, 2013Assignee: Covidien LPInventors: Rafael Ostrowski, Martin Debreczeny
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Patent number: 8399261Abstract: A lateral flow test system together with methods for its use in the detection of one or more analytes, or components, of interest within a sample, such as a biological sample, is provided. The system comprises a liquid formulation of a gold conjugate and a lateral flow assay device that does not include a conjugate pad having conjugate dried thereon.Type: GrantFiled: June 27, 2008Date of Patent: March 19, 2013Assignee: Inbios International, Inc.Inventors: Mazbahul Kabir, Syamal Raychaudhuri, James William Needham, Stanislaw Morkowski
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Patent number: 8383414Abstract: An optic light guide test sensor comprises a light guide, a reagent-coated membrane, and a mesh layer. The reagent-coated membrane and the mesh layer are attached to the light guide at an output end of the light guide. The light guide test sensor is adapted to be used to test the level of an analyte in a biological fluid sample when used with a readhead. A method of manufacturing the light guide test sensor involves providing a plurality of light guides, providing a strip of reagent-coated membrane, and providing a strip of mesh layer. The reagent-coated membrane and mesh layer are attached to the light guides by ultrasonic welding. The reagent-coated membrane and mesh layer may also be attached to the light guides by adhesive.Type: GrantFiled: July 1, 2005Date of Patent: February 26, 2013Assignee: Bayer HealthCare LLCInventors: Jeffery S. Reynolds, Steven C. Charlton, Sung-Kwon Jung, Suny J. George
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Patent number: 8343436Abstract: The invention is characterized in that it has a layer of organic material sensitive to changes in pressure, voltage, deformation, gases and/or temperature; wherein said organic layer consists of at least one conductive salt or complex including a molecule A and a dopant D, said molecule A being an electron donor or acceptor organic molecule or macromolecule capable of forming a conductive salt or complex, which without doping is not conductive, and with the presence of dopant D becomes a compound that is donor or acceptor of electrons and capable of forming conductive salt or complex with the molecule or macromolecule A; and a base substrate, in close contact with said layer of organic material. The sensor device is useful in molecular electronics or plastic electronics, in particular, in the field of organic sensors.Type: GrantFiled: November 13, 2007Date of Patent: January 1, 2013Assignees: Consejo Superior de Investigaciones Cientificas, Institucio Catalana de Recerca I Estudis AvancatsInventors: Elena Laukhina, Marta Mas Torrent, Concepcio Rovira Angulo, Jaume Veclana Miro, Vladimir Laukhin
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Patent number: 8343444Abstract: A device is provided for facilitating preparation of a sample for imaging. The device includes a cartridge having a generally flat, upper surface, a lower surface, an input port extending between the upper and lower surfaces thereof and an output port extending between the upper and lower surfaces thereof. The cartridge includes a first recess in the lower surface thereof having a first end communicating with the input port and a second end communicating with the output port. A cover slip has an upper surface engageable with the lower surface of the cartridge such that a portion of the upper surface of the cover slip communicates with the recess in the lower surface of the recess.Type: GrantFiled: November 1, 2006Date of Patent: January 1, 2013Assignee: Wisconsin Alumni Research FoundationInventor: David J. Beebe
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Patent number: 8313699Abstract: The invention relates to a sterilization testing device comprised of a housing with a test chamber, an indicator placed therein, and with a supply for supplying the sterilization medium. According to the invention, the sterilization testing device consists of at least two housing parts that are matched to one another. A supply channel is made inside the housing part and serves to supply the sterilization medium. The supply channel is configured in such a manner that it forms the base body of the test chamber. The test chamber accommodates the indicator that indicates the completion of the sterilization process. Alternatively to this solution, the invention provides a variant, which is very effective with regard to manufacturing and which permits a quantitative statement regarding the sterilization. Webs are formed inside the housing in the at least partially meandering and/or spiral configuration of the supply channel.Type: GrantFiled: April 8, 2004Date of Patent: November 20, 2012Inventors: Harald Kretschmann, Andreas Rauch
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Patent number: 8313710Abstract: A multilayered optical sensing patch, for the measurement of conditions, such as pH, oxygen level, etc, within containers, is provided. The multilayered optical sensing patch of the present invention is comprised of a heat sealable polymer substrate layer, and a polymeric sensing membrane later attached thereto. The polymer sensing membrane layer is formed of a porous polymer support membrane, and an optical sensing composition (comprising a reactive indicator) covalently bonded thereto. The heat sealable polymer substrate layer is capable of being securely bonded to the inner layer of bioreactor bags, as well as the porous polymer support substrate layer. Further, the porous polymer support membrane layer provides a firm supporting structure for the polymeric sensing layer, thereby protecting the optical sensing composition disposed therein from degradation/damage.Type: GrantFiled: May 16, 2008Date of Patent: November 20, 2012Assignee: Polestar Technologies, Inc.Inventor: James A Kane
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Patent number: 8277752Abstract: An optical measurement apparatus is provided for conducting a test by efficiently reading color development of a reagent after reaction by optical measurement. To the above end, an optical measurement apparatus is provided which is to be used with at least one test instrument mounted to the apparatus. The test instrument includes a carrier provided with at least one reagent retaining portion which retains a reagent, and a sample is applied to the carrier. The optical measurement apparatus includes a reader for reading color development of the reagent retaining portion, and a controller for performing driving control of the reader and determination. The controller performs the determination by utilizing data obtained by a reading operation P to read the color development of the reagent performed after the lapse of a reaction completion period Tr1-Tr6 from the mounting of the test instrument, and the reaction completion period depends on the reagent.Type: GrantFiled: November 20, 2008Date of Patent: October 2, 2012Assignee: ARKRAY, Inc.Inventors: Takashi Nakagawa, Shinya Nakajima, Tokuo Kasai, Kazuhiro Ohmiya
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Patent number: 8277751Abstract: The present invention relates to a tissue paper with pH-indicator function, specifically a toilet paper that can be used to diagnose abnormal pH changes of the human urine as accompanying for instance acetonemic vomiting or diabetes.Type: GrantFiled: June 17, 2005Date of Patent: October 2, 2012Assignee: SCA Hygiene Products GmbHInventors: Walter Hill, Sarah Marinoni
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Publication number: 20120230884Abstract: Provided is a water absorbing material having a granular core portion and a coating layer portion coating the granular core portion, which does not produce color before use and with which a test result can be determined only after use. In the water absorbing material, the coating layer portion is composed of 90 wt % to 96 wt % of a substrate and 10 wt % to 4 wt % of an excretion test material, the excretion test material contains a porous adsorbent having an adsorbance of 25 wt % or greater and including micropores, and an excretion test indicator adsorbed on the micropores of the porous adsorbent, and the excretion test indicator is added in an amount in the range of 0.015 wt % to 0.10 wt % relative to the total amount of the coating layer portion.Type: ApplicationFiled: May 22, 2012Publication date: September 13, 2012Applicant: DAIKI CO., LTD.Inventors: Hiroshi ITO, Shinobu HATANAKA, Takahiro HOSOYA
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Patent number: 8257651Abstract: In one embodiment the present invention provides a blood analyte meter that is user-friendly and easy to use. In accordance with an embodiment of the present invention an analyte measurement device, for use with a test strip for determining the amount of an analyte in a sample, displays a hierarchy of information or options to a user. The hierarchy of information or options may include, among other information or options, subroutines that are performable by the processor of the device, stored data related to past tests performed by the user, and alarm features of the device. A user scrolls through and selects individual options or pieces of information by rotating and translating a rotatable user interface around and along an axis of rotation.Type: GrantFiled: March 16, 2006Date of Patent: September 4, 2012Assignee: AgaMatrix, Inc.Inventors: Joseph Flaherty, Timothy Golnik
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Patent number: 8252248Abstract: The invention relates to an analytical test element for analysis of a liquid sample. The analytical test element may contain a channel which is suitable for capillary transport of the liquid sample and which is provided with an inlet opening for the liquid sample and with an air outlet opening. At least one test field may be arranged in the channel, spaced apart from the inlet opening. The test element comprises a sample application site which is closed with a seal and which is designed in such a way that, when the seal is opened, the sample application site and the inlet opening of the channel are simultaneously open to the outside environment of the test element. The test element can then receive the liquid sample inside the channel via the sample application site and inlet opening, for analysis in the test field. The invention also relates to a test element magazine and to a system for analysis of liquid samples with at least one test element.Type: GrantFiled: July 5, 2005Date of Patent: August 28, 2012Assignee: Roche Diagnostics Operations, Inc.Inventor: Peter Krämer
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Patent number: 8227258Abstract: A liquid delivery apparatus is provided for depositing liquid materials onto prescribed areas. The apparatus includes a sensing and delivery pin and a photo sensor. The apparatus is sized to deliver a droplet of liquid material to the surface of a target area without coming into contact with the target surface. The apparatus is also capable of drawing geometric features, such as lines and grids of liquid material. The photo sensor measures the intensity of light during a processing cycle. Measured reflected-light intensity can be compared in real-time to a reference curve which is based on test process cycles representing the light intensity expected when the process proceeds in the preferred fashion to produce a normal spot having an expected droplet size. The light intensity measurements can also be fitted with a mathematical function such as an asymmetric double sigmoidal curve.Type: GrantFiled: February 11, 2009Date of Patent: July 24, 2012Assignee: New Jersey Institute of TechnologyInventors: Timothy N. Chang, Qiong Shen
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Patent number: 8202734Abstract: A test device and method for determining the presence or absence of an analyte in a fluid sample, the test device including a support bearing a mark thereon, and a matrix defining an axial flow path. In operation, an observation area in the test device becomes transparent, thereby allowing the user to view a mark that is present on a support that is disposed beneath the observation area. Typically, the mark on the underlying support is configured as a minus (?) sign. In the absence of analyte in the sample, the test device presents a negative result as a minus (?) signal. In the presence of analyte in the sample, however, the mark operates in concert with a perpendicular test line on the observation area to present a positive result as a plus (+) signal that is visible to the user.Type: GrantFiled: April 14, 2009Date of Patent: June 19, 2012Assignee: Quidel CorporationInventors: Jeremy Jerome, Mark Daquipa, Bruce Jacono, Hans Boehringer
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Patent number: 8198073Abstract: The present invention relates to a dry stick test device for the determination of an analyte in a sample by means of a chemical assay. The device comprises: (i) optionally a solid support, (ii) at least one reagent pad comprising a reagent capable of reacting with the analyte, a derivative of said analyte or an indicator compound for said analyte to provide a detectable signal when in moistened state, and (iii) a development pad which is located in contact with the at least one reagent pad, optionally between the solid support and the at least one reagent pad, said development pad comprises at least one controlling compound capable of providing a condition required for the reagent to react with the analyte to provide a detectable signal, wherein the at least one reagent pad and the development pad are arranged to avoid precipitation of sample component(s) on the top-face of the device.Type: GrantFiled: January 19, 2007Date of Patent: June 12, 2012Assignee: Lattec I/SInventor: Lars Nygaard
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Patent number: 8193002Abstract: Rapid lateral flow immunoassays have an extensive history of use in both the clinical and home settings. These devices are used to test for a variety of analytes, such as drugs of abuse, hormones, proteins, urine or plasma components and the like. The present invention provides an improved procedural control that indicates to the test user that at least a portion of the applied sample has passed through the test result zone of the test strip, and optionally that the test is complete and the test results may be read.Type: GrantFiled: October 30, 2008Date of Patent: June 5, 2012Assignee: Alere Switzerland GmbHInventors: Huiyan Guo, Min Wang, Tao Shang, Hui-Kang Chen, Fei Gao
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Patent number: 8183058Abstract: It is intended to provide a target substance detection element wherein a target substance capturing body for capturing target substances is immobilized with good orientation in a desired region on the surface of the target substance detection element, a method for producing the target substance detection element, and a detection method using the target substance detection element.Type: GrantFiled: March 17, 2008Date of Patent: May 22, 2012Assignee: Canon Kabushiki KaishaInventors: Satoru Hatakeyama, Takashi Ikeda
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Patent number: 8183059Abstract: Devices and methods for the detection of antigens are disclosed. Devices and methods for detecting food-borne pathogens are disclosed.Type: GrantFiled: August 30, 2011Date of Patent: May 22, 2012Assignee: Invisible Sentinel, Inc.Inventors: Nicholas A. Siciliano, Martin Joseph Bouliane
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Patent number: 8153081Abstract: According to one embodiment of the present invention, an optical-based test sensor for use in the determination of an analyte in a liquid sample is disclosed. The test sensor includes a base, a polymer carrier, and a test membrane. The base has a capillary channel formed in a surface of the base that is adapted to move a liquid sample from an inlet to a reaction area formed in the base. The polymer carrier has a lower surface adhered to the surface of the base and is disposed over at least a portion of the capillary channel. The test membrane, which contains a reagent, is adhered to the lower surface of the polymer carrier and extends from the polymer carrier into the reaction area.Type: GrantFiled: May 14, 2004Date of Patent: April 10, 2012Assignee: Bayer Healthcare LLCInventor: Rex J. Kuriger
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Patent number: 8129195Abstract: A method is provided for producing an analytical element comprising at least one test field for analyzing a liquid sample, wherein provision is made for a carrier on which a polymer fabric is arranged. At least one portion of the polymer fabric is irradiated with UV laser light and thereby hydrophobized.Type: GrantFiled: January 4, 2010Date of Patent: March 6, 2012Assignee: Roche Diagnostics Operations, Inc.Inventors: Josef Roeper, Werner Finke, Beate Koschorreck
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Patent number: 8124025Abstract: Articles for testing a coagulation process in whole blood.Type: GrantFiled: September 13, 2006Date of Patent: February 28, 2012Assignee: Medtronic, Inc.Inventors: Jyotsna Ghai, Charlene X. Yuan, Wei Qin, Mark A. Thompson
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Publication number: 20120045842Abstract: An analysis system for detecting at least one analyte in a sample is proposed, in particular for detecting glucose in a bodily fluid. The analysis system is designed to detect the analyte using at least one test element. The test element has at least one analysis zone for detecting the analyte. The test element furthermore comprises at least one coding with at least one test element specific item of information and/or at least one position specific item of information. The analysis system comprises a detector and furthermore at least one transfer device which is designed to afford the detector the possibility of acquiring the analysis zone in at least a first position and to afford the detector the possibility of acquiring the coding in at least a second position which differs from the first position.Type: ApplicationFiled: February 4, 2011Publication date: February 23, 2012Inventors: Wolfgang Petrich, Stefan Kalveram, Markus Serr
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Patent number: 8101425Abstract: The invention provides devices, test kits and methods for removing target agents from a sample. The device contains one or more porous matrices having pore sizes larger than 10 ?m, and a plurality of particles impregnated therein. The target agents attach the device and are removed from the sample.Type: GrantFiled: June 9, 2005Date of Patent: January 24, 2012Assignee: Pathogen Removal and Diagnostic Technologies Inc.Inventor: Ruben G. Carbonell