Having Coated Reagent Patents (Class 422/425)
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Patent number: 8821810Abstract: The disclosure provides low cost, portable three-dimensional devices for performing multiplexed assays. The devices comprise at least two substantially planar layers disposed in parallel planes, wherein one of the layers is movable relative to each other parallel to the planes to permit the establishment of fluid flow communication serially between the two layers.Type: GrantFiled: February 3, 2011Date of Patent: September 2, 2014Assignee: President and Fellows of Harvard CollegeInventors: George M. Whitesides, Katherine A. Mirica, Andres W. Martinez, Chao-Min Cheng, Scott T. Phillips, Monica Mascareñas, Xinyu Liu, Xiujun Li
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Patent number: 8821811Abstract: Contact lens testing apparatuses and method for testing contact lenses for analytes are presented. In an aspect, a device is provided that includes a housing configured to hold one or more contact lenses, and a testing compartment provided within the housing and comprising a reagent, the reagent configured to facilitate a chemical reaction in response to the existence of a predetermined biomarker disposed on or within a contact lens placed in the testing compartment, wherein the chemical reaction produces a known result related to state information of an individual from which the biomarker was generated.Type: GrantFiled: September 26, 2012Date of Patent: September 2, 2014Assignee: Google Inc.Inventors: Zenghe Liu, James Etzkorn
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Publication number: 20140241954Abstract: A color-appearing ink composition includes a surfactant blend of at least two non-ionic surfactants having hydrophilic-lipophilic balance values greater than 10, or a non-ionic surfactant having a hydrophilic-lipophilic balance value greater than 10 and a charged surfactant. The composition includes one or more water-insoluble leuco dyes, a developer and a desensitizer. The composition may be applied to a substrate to form a sensor.Type: ApplicationFiled: February 26, 2013Publication date: August 28, 2014Applicant: KIMBERLY-CLARK WORLDWIDE, INC.Inventors: Ronnie Lee Phillips, Jeffery Richard Seidling, Corey Thomas Cunningham, Xuedong Song
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Patent number: 8815603Abstract: A chemochromic indicator is provided that includes a hypergolic fuel sensing chemochromic pigment that change from a first color to a second color in the presence of a hypergolic fuel. In a first embodiment, a chemochromic indicator is provided for detecting the presence of a hypergolic fuel such that the irreversible hypergolic fuel sensing chemochromic pigment includes potassium tetrachloroaurate (KAuCl4). There are several types of chemochromic indicators, for example, the article used to form the chemochromic indicators include, but are not limited to, wipe materials, silicone/TEFLON tape, manufactured parts, fabrics, extruded parts, and paints.Type: GrantFiled: July 11, 2012Date of Patent: August 26, 2014Assignee: The United States of America as Represented by the Administrator of the National Aeronautics and Space AdministrationInventors: Luke B. Roberson, Robert W. DeVor, Janine E. Captain, Edgardo Santiago-Maldonado
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Patent number: 8815609Abstract: A lateral flow device includes a sample compressor and a test strip comprising a diverting zone. The diverting zone, which may include a barrier and/or a gap or ditch, stops or impedes flow. Flow is reinitiated and diverted into an alternate plane by compression of a sample compressor. Flow returns to the original, lateral plane, at the end of the diverting zone.Type: GrantFiled: March 7, 2013Date of Patent: August 26, 2014Assignee: Rapid Pathogen Screening, Inc.Inventors: Uma Mahesh Babu, Robert P. Sambursky, Peter Condon, Robert W. VanDine
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Patent number: 8808639Abstract: The present invention relates to a test strip for determining and/or quantifying a property of a sample, such as the concentration of an analyte, the pH, the viscosity, or the specific gravity of a fluid specimen. More particularly, the present invention relates to an improved test strip and scale for determining and/or quantifying a property of a sample, such as the concentration of an analyte, the pH, the viscosity, or the specific gravity of a fluid specimen.Type: GrantFiled: March 20, 2013Date of Patent: August 19, 2014Assignee: Akers BioSciences, Inc.Inventors: Susan Andrelczyk, Leonard Schluter
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Patent number: 8809066Abstract: An analyzing apparatus contains an image detection unit and an analysis unit. The image detection unit contains a view field area that covers at least a reaction area and a background area in a test piece. The reaction area exhibits a reaction color when exposed to a test substance in a specimen. The analysis unit detects the test substance based on the reaction color and determines, during detection of the test substance, whether a state of the background area falls within an acceptable range set for the test substance.Type: GrantFiled: June 20, 2012Date of Patent: August 19, 2014Assignee: Ushio Denki Kabushiki KaishaInventor: Shigeki Matsumoto
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Patent number: 8802427Abstract: The present invention is related to a diagnostic test kit that assesses ovarian reserve by measuring Follicle Stimulating Hormone (FSH) in a liquid sample. The sample can be deposited on a first portion of the device for transport to a second portion of the device. The device can include a release medium formed of a first material and including a detectable label thereon and a capture medium, including a test site, in fluid communication with the release medium and formed of a second, different material.Type: GrantFiled: June 9, 2009Date of Patent: August 12, 2014Assignee: Church & Dwight Co., Inc.Inventors: Albert R. Nazareth, Timothy Snowden, Mary Beth Boyle, Shang Li
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Patent number: 8765075Abstract: In one embodiment, the invention is to a dry reagent composition configured as a solute to be dissolved into whole-blood prior to a whole-blood immunoassay, the dry reagent composition comprising: goat IgG, mouse IgG, dextran, a buffer, proclin, and sodium chloride in a support matrix. In another embodiment, the invention is to a dry reagent composition configured as a solute to be dissolved into whole-blood prior to a whole-blood immunoassay, the dry reagent composition comprising dextran and a salt in a support matrix.Type: GrantFiled: August 15, 2012Date of Patent: July 1, 2014Assignee: Abbott Point of Care, Inc.Inventors: Cary James Miller, Andy Maczuszenko
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Patent number: 8758701Abstract: The invention provides a reagent reservoir system and disposable reaction cassettes using the same. In one aspect, such system comprises a chamber in which dried reagent, particularly lyophilized reagent, is constrained to remain in a defined region of the chamber by a retaining member that obstructs passage of such reagents to other regions of the chamber where they may escape hydration or activation.Type: GrantFiled: April 27, 2012Date of Patent: June 24, 2014Assignee: CepheidInventors: Reuel Van Atta, Dias Lourenco Francisco
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Patent number: 8758690Abstract: A sterilization indicator having a compound that is of the heating type when put into contact with atoms of oxygen O and/or nitrogen N; and a thermochromic dye, in thermal contact with the compound.Type: GrantFiled: February 22, 2013Date of Patent: June 24, 2014Assignee: Societe pour la Conception des Applications des Techniques ElectroniquesInventors: André Ricard, Francis Dieras, Michel Sixou, Sandrine Villeger, Cristina Canal, Pilar Erra
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Publication number: 20140161684Abstract: Provided is a thermal distribution display including, on a support, a thermal distribution display layer that includes at least two electron-donating dye precursors that develop mutually different color tones, the dye precursors including at least one electron-donating dye precursor that decomposes in a temperature range of 190° C. or higher to undergo a change in hue; at least one electron-accepting compound that allows the at least two electron-donating dye precursors to develop colors; and a binder, wherein, in the thermal distribution display layer, a temperature T0.2, at which a density is 0.2 greater than a background density, satisfies the following formula (1). 0.2 T 0.2 - T min ? 0.Type: ApplicationFiled: February 12, 2014Publication date: June 12, 2014Applicant: FUJIFILM CORPORATIONInventor: Kunihiko OOGA
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Patent number: 8747773Abstract: Embodiments of the invention relate to portable detection apparatus, comprising one or more detector regions adapted to visually indicate the presence or amount of an analyte in a beverage. The detection apparatus is shaped substantially the same as a consumer product.Type: GrantFiled: August 11, 2011Date of Patent: June 10, 2014Inventor: Maryse Thomas
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Patent number: 8721990Abstract: Disclosed is an assay device for the determination of the presence and/or extent if an analyte in a liquid sample over an extended concentration range comprising a first assay and a second assay, wherein the first assay for an analyte comprises a first flow-path having a sole detection zone capable of immobilizing a labelled binding reagent and the second assay for said analyte comprises a second flow-path having a sole detection zone capable of immobilizing a labelled binding reagent, wherein the presence of labelled binding reagent at the detection zones provides an indication of the presence and/or extent of analyte in said liquid sample.Type: GrantFiled: April 9, 2008Date of Patent: May 13, 2014Assignee: Alere Switzerland GmbHInventors: Balbir Raj, Saji Eapen, Ezra Linley
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Patent number: 8722424Abstract: In a chromatography quantitative measuring apparatus, a beam applied from a light source to a chromatography test strip is formed into an elliptical shape by an optical means such as a cylindrical lens, a variation in absorbance that accompanies elution of a marker regent is detected while the elliptical beam is applied between a marker reagent hold part and a detection part, and a measurement is automatically started in a prescribed period of time since the detection of variation. According to the chromatography quantitative measuring apparatus so configured, non-uniform coloration is reduced by shaping the beam elliptically with the optical means, whereby the accuracy of quantitative analysis is enhanced, and the apparatus can be operated easily.Type: GrantFiled: December 18, 2009Date of Patent: May 13, 2014Assignee: Panasonic CorporationInventors: Koji Miyoshi, Masahiro Aga, Kaoru Shigematsu
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Patent number: 8722426Abstract: The present invention relates generally to an assay for detecting and differentiating multiple analytes, if present, in a single fluid sample, including devices and methods therefore.Type: GrantFiled: March 5, 2010Date of Patent: May 13, 2014Assignee: Quidel CorporationInventors: Paul Lambotte, Michael Cerrito, Cecille Ramirez
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Patent number: 8722417Abstract: An apparatus is provided for sensing an analyte in a fluid.Type: GrantFiled: January 20, 2007Date of Patent: May 13, 2014Assignee: Invoy Technologies, L.L.C.Inventor: Lubna Ahmad
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Patent number: 8716028Abstract: The invention is directed towards methods and compositions for identifying the amount of hydrofluoric acid in a buffered oxide etching composition. In buffered oxide etching compositions it is very difficult to measure the amount of hydrofluoric acid because it has varying equilibriums and it is toxic so it hard to handle and sample. When used to manufacture microchips however, incorrect amounts of hydrofluoric acid will ruin those chips. The invention utilizes a unique method of spectrographically measuring the hydrofluoric acid when in contact with added chromogenic agents to obtain exact measurements that are accurate, immediate, and safe.Type: GrantFiled: December 31, 2012Date of Patent: May 6, 2014Assignee: Nalco CompanyInventors: Amy Tseng, Brian V. Jenkins, Robert M. Mack
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Patent number: 8709792Abstract: A method and device for detecting analytes in a test sample. Embodiments include methods for quantitatively detecting analytes within a range of concentrations. In an embodiment the method includes a lateral flow test strip with multiple test areas for capturing a labeled receptor to provide a detectable signal.Type: GrantFiled: July 23, 2010Date of Patent: April 29, 2014Assignee: Charm Sciences, Inc.Inventors: Steven J. Saul, Mark E. Tess, Robert J. Markovsky
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Publication number: 20140113280Abstract: Disclosed is a test device and a method for qualitatively and/or quantitatively measuring the concentration of an analyte in a biological fluid sample. The test device includes a housing defining a sample port, a test well containing a stirrer and a conjugate, and a test strip disposed within the housing. The test well is also defined by being located between the sample port and the test strip. Fluid flows from the test well onto the test strip, which has a trapping zone which binds the analyte and allows for its detection. A control zone may also be included. The test device is generally adapted to use a sandwich assay. Also disclosed is a system comprising the test device and a signal sensing device; and a method for using the test device.Type: ApplicationFiled: December 23, 2013Publication date: April 24, 2014Applicant: Instant Medical Diagnostics, LLCInventors: Alan R. Day, Allan M. Weinstein, Bryan C. Christiansen
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Patent number: 8703494Abstract: Described herein are systems and methods for assaying a sample to quantitatively determine the percentage of glycated hemoglobin in the sample.Type: GrantFiled: May 20, 2010Date of Patent: April 22, 2014Assignee: Relia Diagnostic Systems, LLCInventors: William J. Rutter, Jang H. Han, Taewoo Kwon
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Patent number: 8685745Abstract: A multilayered optical sensing patch, for the measurement of conditions, such as pH, oxygen level, etc, within containers, is provided. The multilayered optical sensing patch of the present invention is comprised of a heat sealable polymer substrate layer, and a polymeric sensing membrane later attached thereto. The polymer sensing membrane layer is formed of a porous polymer support membrane, and an optical sensing composition (comprising a reactive indicator) covalently bonded thereto. The heat sealable polymer substrate layer is capable of being securely bonded to the inner layer of bioreactor bags, as well as the porous polymer support substrate layer. Further, the porous polymer support membrane layer provides a firm supporting structure for the polymeric sensing layer, thereby protecting the optical sensing composition disposed therein from degradation/damage.Type: GrantFiled: October 26, 2011Date of Patent: April 1, 2014Assignee: Polestar Technologies, Inc.Inventor: James A. Kane
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Patent number: 8668871Abstract: Provided are a sensing device and a biosensor that are capable of achieving stable performance in sensing saccharides or hydroxyl group-containing polymers, and that can be stored for a long time. The biosensor 8 of the present invention uses, as a component for sensing glucose, a sensing device 16 in which a completely synthetic phenylboronic acid compound 21 is bound without using enzymes that have been conventionally used. Consequently, the biosensor 8 can eliminate the problem of protein denaturation to achieve stable performance in sensing glucose, and it is possible to achieve the biosensor 8 can be stored for a long time.Type: GrantFiled: July 20, 2011Date of Patent: March 11, 2014Assignee: National Institute for Materials ScienceInventors: Akira Matsumoto, Yuji Miyahara
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Patent number: 8663578Abstract: A liquid droplet introducing tank 3A includes a tank body 31, which is formed by mutually opposing top surface 31a and bottom surface 31b, and a side surface 31c. The tank also includes an injection hole 32 that is opened in the top surface 31a. Liquid droplets Dr are injected from the injection hole 32. The center of the injection hole 32 is closer to the side surface 31c than the center of the top surface 31a. The liquid droplet introducing tank 3A enables liquid droplets to be suitably injected therein and is suitable for reducing size.Type: GrantFiled: March 30, 2009Date of Patent: March 4, 2014Assignee: ARKRAY, Inc.Inventor: Yukihiro Sukawa
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Patent number: 8647575Abstract: A blood glucose meter includes a front attachment part to which a test piece is attached, a measurement part for measuring a component of blood collected via a blood guide passage in the test piece, and a monitor for displaying the measurement results obtained by the measurement part. When the device is placed on a horizontal plane by referring to the display face of the monitor as the upper side and the opposite side as the lower side and placing the display face of the monitor upward, the central axis of the test piece extends obliquely downward toward the front side. The blood glucose meter comprises a main part provided with the monitor and a linking part between the main part and the front attachment part. The top face of the linking part is placed roughly parallel to the central axis line and is provided with an ejector lever.Type: GrantFiled: November 19, 2009Date of Patent: February 11, 2014Assignee: Terumo Kabushiki KaishaInventor: Hirotaka Ohashi
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Patent number: 8647589Abstract: An object of the invention is to provide various flow cells and a method for manufacturing the same, in which formation of a groove on a substrate and formation of components such as an electrode, auxiliary parts such as a pump are not necessary. The inventive flow cells are capable of realize complicated chemical analysis or synthesis or the like. A channel of a porous member provided on a sample-incompatible substrate is formed; the porous member is composed of an air non-contact region having a network structure and an air contact region covering the air non-contact region and having a lower pore density than the air non-contact region; in which a capillary force to be generated within the porous member is a drive force for pumping a liquid.Type: GrantFiled: July 20, 2012Date of Patent: February 11, 2014Assignee: Nippon Telegraph and Telephone CorporationInventors: Tsutomu Horiuchi, Toru Miura, Yuzuru Iwasaki, Jyunichi Takahashi, Katsuyoshi Hayashi, Tsuneyuki Haga, Michiko Seyama, Serge Camou
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Patent number: 8632740Abstract: A collection device and a method for collecting a biological sample, particularly whole blood, includes a separating member to separate the whole blood into its components, and at least reagent positioned to selectively interact with a component of the separated sample. The reagent is able to selectively interact with the plasma/serum, and is prevented from contacting or interacting with the whole blood.Type: GrantFiled: May 4, 2010Date of Patent: January 21, 2014Assignee: Becton, Dickinson and CompanyInventors: Ajit Dastane, Dimitrios Manoussakis, Christopher Battles, Paul Dicesare, Jeffrey Radziunas
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Patent number: 8632730Abstract: In one aspect, a diagnostic test system includes a receptacle, optical detectors, and a logic circuit. Each of the optical detectors has a corresponding view in the receptacle and produces an electrical signal at a respective detector output in response to light from the corresponding view. The logic circuit includes logic inputs that are respectively coupled to the detector outputs and that produce an output logic signal corresponding to a logical combination of signals received at the logic inputs. In another aspect, respective detection signals are produced in response to light received from respective ones of multiple views of the test strip, and at least one output logic signal corresponding to a respective logical combination of the detection signals is generated.Type: GrantFiled: November 22, 2005Date of Patent: January 21, 2014Assignee: Alverix, Inc.Inventors: John F. Petrilla, Daniel B. Roitman
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Publication number: 20140017145Abstract: A three-dimensional porous photonic structure, whose internal pore surfaces can be provided with desired surface properties in a spatially selective manner with arbitrary patterns, and methods for making the same are described. When exposed to a fluid (e.g., via immersion or wicking), the fluid can selectively penetrate the regions of the structure with compatible surface properties. Broad applications, for example in security, encryption and document authentication, as well as in areas such as simple microfluidics and diagnostics, are anticipated.Type: ApplicationFiled: November 21, 2011Publication date: January 16, 2014Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Joanna Aizenberg, Ian B. Burgess, Lidiya Mishchenko, Benjamin Hatton, Marko Loncar
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Publication number: 20140010729Abstract: An electronic device for analyzing an aqueous solution may comprise a housing, one or more measurement circuits and a control circuit all arranged inside the housing. The housing may be configured to receive a test element. The one or more measurement circuits may be configured to produce one or more corresponding sets of measurement signals relating to an aqueous solution received on the test element. The control circuit may include a memory having instructions stored therein that are executable by the control circuit to process the one or more sets of measurement signals to determine one or more corresponding characteristics of the aqueous solution.Type: ApplicationFiled: September 11, 2013Publication date: January 9, 2014Applicant: HACH COMPANYInventors: David Alexander Nathaniel Morris, Teresa Lynn Swanson
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Publication number: 20130343963Abstract: A fluid sensor comprises a formed plastic body and a reagent. The body has a top face with an integral first surface. The body also has a bottom face opposed to the first surface and a sidewall that extends from the periphery of the top face. The first surface is adapted to accept a fluid sample. The reagent is disposed on the integral first surface and causes a color change detectable on the bottom face when the reagent reacts with an analyte in the fluid sample.Type: ApplicationFiled: August 26, 2013Publication date: December 26, 2013Applicant: Bayer HealthCare, LLCInventors: Sung-Kwon Jung, Steven C. Charlton, Suny J. George, Andrew J. Dosmann, Karen L. Marfurt
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Patent number: 8614101Abstract: Devices and methods incorporate lysis agents into a point-of-care testing device. The sample is loaded, and then the sample travels until it encounters a lysis agent. The lysis agent is preferably pre-loaded onto the collection device. In a preferred embodiment, the initially lysis agent is localized between the sample application zone and the conjugate zone. The lysis agent is preferably soluble or miscible in the sample transport liquid, and the lysis agent is solubilized and activated upon contact with the sample transport liquid. The sample transport liquid then contains both lysis agent in solution or suspension and sample components in suspension. Any lysis-susceptible components in a sample, then being exposed in suspension to the lysis agent, are themselves lysed in situ. The running buffer then carries the analyte, including any lysis-freed components, to the detection zone.Type: GrantFiled: July 14, 2009Date of Patent: December 24, 2013Assignee: Rapid Pathogen Screening, Inc.Inventors: Robert W. VanDine, Uma Mahesh Babu, Robert P. Sambursky
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Patent number: 8603832Abstract: Embodiments of the invention provide lateral flow and flow-through bioassay devices based on patterned porous media, methods of making same, and methods of using same. Under one aspect, an assay device includes a porous, hydrophilic medium; a fluid impervious barrier comprising polymerized photoresist, the barrier substantially permeating the thickness of the porous, hydrophilic medium and defining a boundary of an assay region within the porous, hydrophilic medium; and an assay reagent in the assay region.Type: GrantFiled: December 28, 2012Date of Patent: December 10, 2013Assignee: President and Fellows of Harvard CollegeInventors: George M. Whitesides, Scott T. Phillips, Andreas W. Martinez, Manish J. Butte, Amy Wong, Samuel W. Thomas, Hayat Sindi, Sarah J. Vella, Emanuel Carrilho, Katherine A. Mirica, Yanyan Liu
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Patent number: 8603835Abstract: Test cells have a first sorbent strip with a sample receiving location and defining a first migration path, a distinct second sorbent strip which receives buffer solution and at least partially defines a second migration path distinct from and elongated relative to the first migration path, conjugate supported by the second strip, a test site located at a junction of the first and second strips and having an immobilized ligand-binding mechanism, and a divider which directs a first amount of the buffer to the first strip to move the sample to the test site and a second amount to the second strip to move the conjugate to the test site. The first and second migration paths have first and second lengths chosen so that ligand in the sample reaches the test site and binds to the immobilized ligand-binding mechanism prior to the conjugate reaching the test site.Type: GrantFiled: February 10, 2011Date of Patent: December 10, 2013Assignee: Chembio Diagnostic Systems, Inc.Inventor: Javanbakhsh Esfandiari
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Patent number: 8597591Abstract: Muscle cramps can be reduced or avoided by monitoring the concentration of salt in perspiration to indicate the degree of salt depletion. Based on the degree of salt depletion, a sufficient amount of rehydration beverage is consumed to normalize the salt level.Type: GrantFiled: July 31, 2008Date of Patent: December 3, 2013Assignee: Stokely-Van Camp, Inc.Inventors: Robert Murray, John R. Stofan, IV, Jeffrey J. Zachwieja, Craig A. Horswill, Myron C. Rapkin, Wayne W. Weber
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Patent number: 8591828Abstract: An optical hydrogen gas detecting membrane is prepared by sequentially depositing a platinum oxide layer and a catalytic metal layer on a transparent substrate, such as quartz glass, by vapor deposition such as the sputtering method. Palladium or platinum is used as the catalytic metal layer.Type: GrantFiled: May 14, 2008Date of Patent: November 26, 2013Assignee: Japan Atomic Energy AgencyInventors: Shunya Yamamoto, Katsuyoshi Takano, Aichi Inouye, Masahito Yoshikawa
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Patent number: 8585983Abstract: The disclosed invention is a composition for a humidity indicating device comprising (a) an organic pH indicator dye compound, (b) a Bronsted acid or base, and (c) a polyol having the general formula HOCH2—(CHOH)n—CH2OH, wherein n can be 0, 1, 2, 3 or 4, wherein said components (a), (b), and (c) do not contain halogen and/or heavy metals. Furthermore, the invention relates to a humidity indicator device comprising a sheet substrate and the composition for a humidity indicating device containing no heavy metals or halogen compounds, and to a process for preparing said humidity indicator device.Type: GrantFiled: June 22, 2011Date of Patent: November 19, 2013Assignee: Sud-Chemie IP GmbH & Co. KGInventors: Johanna Knyrim, Stefan Dick
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Patent number: 8586377Abstract: An analytical test element is provided having a surface comprising a chemical detection layer on which a spreading net is disposed, the spreading net being configured to provide for the planar distribution of a liquid sample on the detection layer. The spreading net generally comprises a filament structure coated with a metallic layer that is oxidized at least on one or more surface portions thereof facing the detection layer.Type: GrantFiled: August 17, 2012Date of Patent: November 19, 2013Assignee: Roche Diagnostics Operations, Inc.Inventors: Otto Fuerst, Hans-Peter Haar
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Patent number: 8580572Abstract: The invention relates to a lateral flow assay test strip and a method for making the same. The strip comprises, in the flow direction, a selectively activated membrane for a test reaction and an absorption pad, which are both made of paper and may comprise an integral paper strip. The absorption pad has the paper strip embossed and/or folded to increase the strip's absorption capacity. The folded pad may have an accordion-like configuration, the strip running to-and-from, or it may have the strip rolled and then flattened to a stack of layers.Type: GrantFiled: May 3, 2010Date of Patent: November 12, 2013Assignee: Teknologian TutkimuskeskusInventor: Timo Lappalainen
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Patent number: 8563330Abstract: The invention provides a device and method for the rapid identification of patients suspected of having thalassemia. The invention provides a test strip for the aqueous detection of thalassemia related proteins in whole blood. The test strip includes antibodies specific to the gamma 4, (?4) protein and provides easy visual discrimination between a positive result and a negative result. The invention can be used in remote or clinical settings.Type: GrantFiled: March 21, 2008Date of Patent: October 22, 2013Assignee: National Science and Technology Development AgencyInventors: Watchara Kasinrerk, Chatchai Tayapiwatana, Thanusak Tatu, Suthat Fucharoen, Sawitree Chiampanichayakul
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Patent number: 8557748Abstract: An immobilization method for immobilizing a physiologically active substance on a solid phase carrier, the method including: bringing the solid phase carrier into contact with an acid anhydride functional group-containing silane coupling agent represented by the following Formula (I); and carrying out a process of binding of the physiologically active substance to the acid anhydride functional group while maintaining the solid phase carrier after the contact at a temperature within the range of 0° C. to 60° C.; a physiologically active substance-immobilized carrier, and a carrier for immobilization are provided. Further, a carrier including a porous material treated with an acid anhydride functional group-containing silane coupling agent represented by the following Formula (I), a blocking agent that is immobilized to the porous material; and a method for producing it is provided.Type: GrantFiled: February 5, 2013Date of Patent: October 15, 2013Assignee: FUJIFILM CorporationInventors: Morihito Ikeda, Taisei Nishimi, Junichi Katada
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Patent number: 8557195Abstract: A sensor substrate includes a base and fibrous projections on an upper surface of the base. The fibrous projections have fixed ends fixed to the upper surface of the base and free ends opposite to the fixed ends, respectively. The fibrous projections provide a fixed end-side region including the fixed ends and a free end-side region including the free ends. The total surface area at which the fibrous projections in the fixed end-side region is larger than that in the free end-side region.Type: GrantFiled: September 14, 2012Date of Patent: October 15, 2013Assignee: Panasonic CorporationInventors: Masaya Nakatani, Makoto Takahashi, Takuya Oka
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Patent number: 8557596Abstract: The invention provides a sensor for detecting nitrogen containing high explosives. The sensor includes a substrate and a blue-photoluminescent metallofluorene copolymer to be carried on said substrate during testing for nitrogen containing high explosives. The copolymer is preferably a blue-photoluminescent metallofluorene copolymer, and preferably is a vinyl bridged silafluorene copolymer. A method for detecting nitrogen containing high explosives involves exposing a copolymer to an analyte, preferably by spraying the copolymer or otherwise coating the substrate after it has been exposed to analyte and then exciting the copolymer to luminesce. The copolymer is observed for fluorescence quenching, which can be through human or electronic observation. The invention also provides for synthesis of a vinyl bridged silafluorene polymer by providing diethynylmetallofluorene and dihydrosilafluorene as precursors and conducting catalytic hydrosilation of the precursors.Type: GrantFiled: July 10, 2008Date of Patent: October 15, 2013Assignee: The Regents of the University of CaliforniaInventors: William C. Trogler, Jason Sanchez
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Patent number: 8557604Abstract: A lateral flow, membrane-based assay device for detecting the presence or quantity of an analyte residing in a test sample is provided. The device utilizes phosphorescence to detect the signals generated by excited phosphorescent labels. The labels may have a long emission lifetime so that background interference from many sources, such as scattered light and autofluorescence, is practically eliminated during detection. In addition, the phosphorescent labels may be encapsulated within particles to shield the labels from quenchers, such as oxygen or water, which might disrupt the phosphorescent signal.Type: GrantFiled: December 14, 2007Date of Patent: October 15, 2013Assignee: Kimberly-Clark Worldwide, Inc.Inventor: Xuedong Song
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Patent number: 8557595Abstract: The invention provides a sensor for detecting nitrogen containing high explosives. The sensor includes a substrate and a blue-photoluminescent metallofluorene copolymer to be carried on said substrate during testing for nitrogen containing high explosives. The copolymer is preferably a blue-photoluminescent metallofluorene copolymer, and preferably is a vinyl bridged silafluorene copolymer. A method for detecting nitrogen containing high explosives involves exposing a copolymer to an analyte, preferably by spraying the copolymer or otherwise coating the substrate after it has been exposed to analyte and then exciting the copolymer to luminesce. The copolymer is observed for fluorescence quenching, which can be through human or electronic observation. The invention also provides for synthesis of a vinyl bridged silafluorene polymer by providing diethynylmetallofluorene and dihydrosilafluorene as precursors and conducting catalytic hydrosilation of the precursors.Type: GrantFiled: January 29, 2008Date of Patent: October 15, 2013Assignee: The Regents of the University of CaliforniaInventors: William C. Trogler, Jason Sanchez
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Patent number: 8541227Abstract: The inventions relates to compositions and method for determining the absolute counts of cells per unit volume of a sample. Such a method comprises: (a) providing a container containing (i) a predetermined quantity of microparticles; and (ii) a cell-binding agent; in which the microparticles are disposed in or on a matrix which adheres to at least one wall of the container such that substantially all the microparticles are thereby attached to the container; (b) adding a known volume of sample to the container; (c) determining the ratio of microparticles to cells by counting microparticles and cells in a volume of the sample; and (d) determining the absolute count of cells by multiplying the number of cells per microparticle by the concentration of microparticles in the sample.Type: GrantFiled: February 6, 2006Date of Patent: September 24, 2013Assignee: Dako Denmark A/SInventors: Nanna K Christensen, Jesper Laursen, Lars Winther
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Publication number: 20130243645Abstract: The present disclosure generally relates to a color indicator that signals when the concentration of an antimicrobial solution changes. In some embodiments, the color indicator is specific for changes in the concentration of an antimicrobial quaternary ammonium compound in an antimicrobial solution. The color indicator can be incorporated into a variety of articles including towels, labels, containers, buckets, trays, sinks, spray bottles, liners for containers, buckets, sinks, or spray bottles, indictor wands or strips, and test kits.Type: ApplicationFiled: September 6, 2012Publication date: September 19, 2013Applicant: ECOLAB USA INC.Inventors: Eric Balz, Kim R. Smith, Erik C. Olson, Sherri Tischler
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Patent number: 8535617Abstract: A lateral flow device for analyzing a whole blood sample is provided. More specifically, the lateral flow device contains a porous membrane that defines a barrier zone for separating red blood cells from blood plasma (includes plasma in which clotting factors haven been removed), which may then flow to a subsequent detection zone for analysis. The barrier zone is formed from a blood cell barrier composition that includes an unsaturated aliphatic fatty acid or an ester thereof. Without intending to be limited by theory, the present inventors believe such unsaturated aliphatic fatty acid molecules undergo autoxidation in the presence of air and hemoglobin to release peroxides (e.g., hydrogen peroxide) via oxidative saturation of double bonds. In turn, the released peroxides are believed to induce the formation of echinocytes or crenated blood cells.Type: GrantFiled: November 30, 2007Date of Patent: September 17, 2013Assignee: Kimberly-Clark Worldwide, Inc.Inventors: J. Gavin MacDonald, Molly K. Smith
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Patent number: 8518343Abstract: Solid matter in a cavity is used to produce a solution of at least one solid matter in a solvent. The solid matter which is soluble in the solvent in initially covered and/or surrounded in the cavity by a medium which is insoluble in a solvent, such that dissolving of the solid matter is prevented. Subsequently the solvent is guided to the cavity and the medium which is insoluble in the solvent is treated in such a manner that contact is made between the solvent and the soluble solid matter, enabling the solid matter to dissolve in the solvent. Solutions including two or more solid matter can be produced in an advantageous manner.Type: GrantFiled: April 26, 2005Date of Patent: August 27, 2013Assignee: Siemens AktiengesellschaftInventors: Walter Gumbrecht, Peter Paulicka, Manfred Stanzel
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Patent number: 8518344Abstract: The disclosed invention is a humidity indicating composition comprising (a) an organic pH indicator dye compound, (b) a Bronsted acid or base, (c) a polyol having the general formula HOCH2—(CHOH)n—CH2OH, wherein n can be 0, 1, 2, 3 or 4, and (d) a solvent; wherein said components (a), (b), (c) and (d) do not contain halogen and/or heavy metals. Furthermore, the invention relates to a humidity indicator card comprising a sheet substrate and the humidity indicating composition from which the solvent has been allowed to evaporate, and to a process for preparing said humidity indicator card.Type: GrantFiled: December 23, 2010Date of Patent: August 27, 2013Assignee: Sud-Chemie IP GmbH & Co., KGInventors: Johanna Knyrim, Stefan Dick