Including Integral Heat-exchange Means Patents (Class 422/46)
  • Patent number: 11344662
    Abstract: According to some embodiments, a system may treat blood outside the body of a patient. The system may include one or more pumps configured to draw blood from a patient into a fluid flow path at a rate, for example, of 5-7 liters per minute. The system may include one or more heat exchangers coupled to the fluid flow path and configured to heat the blood, for example, to a temperature above 42 degrees Celsius and below 43.2 degrees Celsius.
    Type: Grant
    Filed: February 16, 2015
    Date of Patent: May 31, 2022
    Assignee: HUMANITY LIFE EXTENSION LLC
    Inventors: Patrick Richard Spearman, Alexander Patrick Spearman
  • Patent number: 11291754
    Abstract: A system for the extracorporeal elimination of carbon monoxide, includes at least one pump and a gas exchange chamber, wherein the at least one pump can be connected to the blood circulatory system of a person by way of a first tube section connectable to a cannula and is connected to a gas exchange chamber via a second tube section, wherein the system is configured to transfer blood, via the first tube section, from the blood circulatory system of the person by way of at least one pump into the gas exchange chamber, and to return the blood from the gas exchange chamber to the blood circulatory system of the person via the same first tube section.
    Type: Grant
    Filed: February 14, 2017
    Date of Patent: April 5, 2022
    Assignee: RHEINISCH-WESTFAELISCHE TECHNISCHE HOCHSCHULE (RWTH) AACHEN
    Inventors: Jutta Arens, Ralf Borchardt, Peter Christian Schlanstein, Thomas Schmitz-Rode, Lotte Schraven, Georg Wagner, Ulrich Steinseifer
  • Patent number: 10730018
    Abstract: There is described a method of use of a mass exchanger. In the method the mass exchanger comprises: a first channel for accommodating flow of a liquid to be treated; and a second channel for accommodating flow of a treatment agent, the first and second channels have a permeable membrane provided between them, so as to allow transfer of selected species between the first channel and the second channel. The steps of the mass transfer method comprise passing the liquid to be treated along the first channel and introducing a mixture of liquid and gas into the second channel to provide a two-phase treatment agent. It is desirable to provide a means of adjusting the concentration of gas species in a liquid such as blood, while simultaneously controlling the temperature of the liquid and optionally adjusting the concentration of ionic and/or dissolved species in that liquid. By this method and mass exchanger providing a two-phase treatment agent, it is possible to simultaneously deliver gaseous species (e.g.
    Type: Grant
    Filed: January 18, 2016
    Date of Patent: August 4, 2020
    Assignee: Haemair Limited
    Inventors: William R. Johns, Alan F. Evans, Ronald K. Knight
  • Patent number: 10633631
    Abstract: A platelet rich plasma preparation system and devices having a whole blood centrifuge tube (100) and a plasma centrifuge tube (200) wherein fill tubes (206) and vent tubes (113) are in fixed position and guards are provided to protect the fill tubes and vent tubes during use with a centrifuge. The fixed tubes and guards (114, 210) prevent kinks in the tubes and/or blockages that render the components of the system and the samples contained therein useless.
    Type: Grant
    Filed: March 1, 2017
    Date of Patent: April 28, 2020
    Inventor: Gerald R. Harris
  • Patent number: 9724481
    Abstract: A gas delivery system supplying a body cavity with a given gas includes a first guide pipe for supplying the given gas into the body cavity and a second guide pipe installed in the first guide pipe for supplying the given gas into the body cavity at a flow velocity that differs from that of the first guide pipe. A flow velocity of the given gas that is supplied from a first conduit which is formed by the first guide pipe and the second guide pipe is faster than a flow velocity of the given gas that is supplied from a second conduit which is formed in the second guide pipe.
    Type: Grant
    Filed: September 2, 2014
    Date of Patent: August 8, 2017
    Assignee: OLYMPUS CORPORATION
    Inventor: Yuma Kasuya
  • Patent number: 9408960
    Abstract: Methods of making a combination heat exchanger and oxygenator. A heat transfer tubing is wound about a core and a potting compound is applied to a portion of the wound tubing. The potting compound solidifies to form a potting structure defining an internal face substantially parallel with a longitudinal axis of the core. The assembly is cut along a line passing through the potting structure to define a core assembly having a cut face substantially parallel with the axis. The cut tubing forms a plurality of capillary tubes, each terminating at opposing, first and second ends, and each extending about the core along an arc angle of less than 360 degrees. An oxygenator bundle is formed as part of the core assembly and includes a plurality of gas exchange fibers. The core assembly is disposed within a housing having a blood inlet and a blood outlet.
    Type: Grant
    Filed: December 19, 2013
    Date of Patent: August 9, 2016
    Assignee: Medtronic, Inc.
    Inventor: Alford McLevish
  • Patent number: 9402943
    Abstract: A blood processing apparatus may include a heat exchanger and a gas exchanger. At least one of the heat exchanger and the gas exchanger may be configured to impart a radial component to blow flow through the heat exchanger and/or gas exchanger. The heat exchanger may be configured to cause blood flow to follow a spiral flow path.
    Type: Grant
    Filed: January 16, 2014
    Date of Patent: August 2, 2016
    Assignee: Sorin Group Italia S.r.l.
    Inventors: Stefano Reggiani, Gianfranco Beniamino Fiore, Alberto Redaelli, Christian Baiotto
  • Patent number: 9327251
    Abstract: The invention provides a microbubble generation system with increased efficiency and flexibility compared to known systems. Further, the invention provides a method of microbubble generation. In particular, invention relates to increasing the efficiency of a fermentation reaction by reducing bubble size and increasing gas absorption into a liquid fermentation broth.
    Type: Grant
    Filed: January 28, 2014
    Date of Patent: May 3, 2016
    Assignee: LANZATECH NEW ZEALAND LIMITED
    Inventor: Xueliang Li
  • Patent number: 9314743
    Abstract: A reverse osmosis system that includes a housing having an inlet port, a permeate port and a concentrate port. The reverse osmosis system further includes a membrane element within the housing and (i) a first connector that has an end which is connected to the inlet port; (ii) a second connector that has an end which is connected to the permeate port; and (iii) a third connector that has an end which is connected to the concentrate port. The end of the first connector fits the inlet port but does not fit the permeate port or the concentrate port. The end of the second connector fits the permeate port but does not fit the inlet port or the concentrate port. The end of the third connector fits the concentrate port but does not fit the inlet port or the permeate port.
    Type: Grant
    Filed: September 11, 2008
    Date of Patent: April 19, 2016
    Assignee: Pentair Residential Filtration, LLC
    Inventors: Steven D. Kloos, Philip M. Rolchigo, Christopher J. Kurth, Chia Kung, Thomas J. Cartwright, Richard M. Reckin, Kenneth J. Sieth
  • Patent number: 8980176
    Abstract: A blood processing apparatus may include a heat exchanger and a gas exchanger. The heat exchanger may be configured to provide a cross-flow or radially directed blood flow through the heat exchanger.
    Type: Grant
    Filed: May 18, 2011
    Date of Patent: March 17, 2015
    Assignee: Sorin Group Italia S.r.l.
    Inventors: Stefano Reggiani, Claudio Giovannini, Claudio Silvestri, Gabriele Tommasi
  • Patent number: 8906300
    Abstract: A blood oxygenator includes an integral pneumatic pump disposed substantially within a housing thereof, an inlet blood flow redirector, and an outflow blood collector. An atrium provided at an inlet of the oxygenator promotes even delivery of blood to the oxygenator. In use, the oxygenator provides an even dispersion of blood therethrough, establishing even perfusion and reducing areas of stagnant blood flow.
    Type: Grant
    Filed: August 13, 2012
    Date of Patent: December 9, 2014
    Assignee: The University of Kentucky Research Foundation
    Inventors: Dongfang Wang, Joseph B. Zwischenberger
  • Publication number: 20140227133
    Abstract: A blood processing apparatus may include a heat exchanger and a gas exchanger. At least one of the heat exchanger and the gas exchanger may be configured to impart a radial component to blow flow through the heat exchanger and/or gas exchanger. The heat exchanger may be configured to cause blood flow to follow a spiral flow path.
    Type: Application
    Filed: January 16, 2014
    Publication date: August 14, 2014
    Applicants: Politecnico di Milano, Sorin Group Italia S.r.l.
    Inventors: Stefano Reggiani, Gianfranco Beniamino Fiore, Alberto Redaelli, Christian Baiotto
  • Patent number: 8795591
    Abstract: An apparatus for oxygenating blood including a housing and an oxygenator bundle. The housing defines a primary chamber, a blood inlet port open to the primary chamber, and a blood outlet region. The outlet region includes a blood outlet port, an outlet chamber open to the outlet port, and a partition. The partition establishes spaced apart, first and second passageways from the primary chamber to the outlet chamber. The oxygenator bundle is disposed within the primary chamber. A blood flow path is formed from the blood inlet port, through the oxygenator bundle and to the blood outlet port, and includes first and second outlet flow paths within the outlet chamber via the first and second passageways, respectively. The first and second outlet blood flow paths merge at the blood outlet port. A dual port blood outlet is created, increasing mixing of blood immediately upstream of the outlet port.
    Type: Grant
    Filed: February 15, 2012
    Date of Patent: August 5, 2014
    Assignee: Medtronic, Inc.
    Inventors: Stephen Roller, Christopher Plott, Alford McLevish, Gregory Hake, Brian Steffens
  • Patent number: 8747742
    Abstract: A heat exchanger includes a case, a bottom member and a plurality of heat transfer pipes (a pipe group) loaded in the heat exchanger case, in which blood flows from one end through the bottom member. The bottom member has an annular wall, a bottom surface, and a blood inlet port. The bottom surface is opposed to one end of the heat transfer pipe. The bottom surface includes a groove portion and a raised bottom portion provided on each of opposing end sides of the groove portion. The raised bottom portion is inclined such that a distance between the raised bottom portion on a side where the blood inlet port is provided and one end of the heat transfer pipe is smaller than a distance between the raised bottom portion opposite to the side where the blood inlet port is provided and one end of the heat transfer pipe.
    Type: Grant
    Filed: February 15, 2011
    Date of Patent: June 10, 2014
    Assignee: Nipro Corporation
    Inventors: Shin-ichi Kawamura, Kazuhisa Ishihara, Naoaki Yasumura
  • Publication number: 20140154137
    Abstract: The invention relates to an apparatus and a process for mass- and/or energy-transfer between two media, in particular between blood and a gas/gas mixture, having a chamber (1) through which a first medium, in particular blood, flows and in which a bundle of mass- and/or energy-permeable hollow fibres through which the second medium can flow and around which the first medium can flow is arranged transverse to the flow direction of the first medium, in which the chamber (1) is configured as an elastic shell (3) at least in a region which completely surrounds the bundle, where a rigid housing (6) is arranged around the elastic shell (3) and the inner wall of the housing contacts the shell (3) in a plurality of first regions (9) and the inner wall of the housing is not in contact with and is in particular at a spacing from the shell (3) in at least one second region (10), preferably a plurality of second regions (10) in the direction of the extension of the hollow fibres, where the one hollow space or at least on
    Type: Application
    Filed: May 31, 2011
    Publication date: June 5, 2014
    Inventor: Ahmad Ali Kashefi Khorasani
  • Patent number: 8685320
    Abstract: An oxygenator which helps avoid bubbles in the blood from being discharged through the blood outlet port of the oxygenator includes a housing, a hollow fiber membrane bundle in the housing and formed by a multiplicity of hollow fiber membranes serving for gas exchange, gas-inlet and gas-outlet ports communicating with gas passages of the hollow fiber membranes, and a blood-inlet and blood-outlet ports. A filter member is provided on a side closer to the blood outlet port of the hollow fiber membrane bundle and serves to catch bubbles in blood. The blood outlet port projects from the housing and a passage enlargement is provided in a vicinity of the end of the blood outlet port closer to the housing and having an increased passage cross-sectional area. The blood passed the filter member is allowed to reach the blood outlet port by being decelerated in the passage enlargement.
    Type: Grant
    Filed: May 20, 2010
    Date of Patent: April 1, 2014
    Assignee: Terumo Kabushiki Kaisha
    Inventors: Mitsuaki Ogihara, Hidetaka Nakayama, Kazuhiro Mizoguchi
  • Patent number: 8685319
    Abstract: A combination oxygenator and arterial filter device for treating blood in an extracorporeal blood circuit. The device includes a housing maintaining a core and a fiber bundle. The fiber bundle is formed by a plurality of hollow fibers continuously helically wound about the core to form layers of level wound fibers. The layers combine to define an oxygenator region and a radially outward depth filter region. A minimum gap spacing between fibers of the oxygenator region layers is greater than a minimum gap spacing of the depth filter region layers. The fiber bundle can function as a blood oxygenator and exhibits a filtration efficiency of not less than 92% in filtering particles having a particle size of about 45 microns. An oxygenator with integrated arterial filtering capability is provided that minimally impacts the extracorporeal blood circuit prime volume.
    Type: Grant
    Filed: April 29, 2011
    Date of Patent: April 1, 2014
    Assignee: Medtronic, Inc.
    Inventors: Robert Olson, John L. Knoll
  • Publication number: 20140050617
    Abstract: An apparatus for oxygenating blood including a housing and an oxygenator bundle. The housing defines a primary chamber, a blood inlet port open to the primary chamber, and a blood outlet region. The outlet region includes a blood outlet port, an outlet chamber open to the outlet port, and a partition. The partition establishes spaced apart, first and second passageways from the primary chamber to the outlet chamber. The oxygenator bundle is disposed within the primary chamber. A blood flow path is formed from the blood inlet port, through the oxygenator bundle and to the blood outlet port, and includes first and second outlet flow paths within the outlet chamber via the first and second passageways, respectively. The first and second outlet blood flow paths merge at the blood outlet port. A dual port blood outlet is created, increasing mixing of blood immediately upstream of the outlet port.
    Type: Application
    Filed: February 15, 2012
    Publication date: February 20, 2014
    Applicant: Medtronic, Inc.
    Inventors: Stephen Roller, Chistopher Plott, Alford McLevish, Gregory Hake, Brian Steffens
  • Patent number: 8652406
    Abstract: A blood processing apparatus includes a heat exchanger and a gas exchanger. At least one of the heat exchanger and the gas exchanger is configured to impart a radial component to blow flow through the heat exchanger and/or gas exchanger. In some instances, the heat exchanger is configured to cause blood flow to follow a spiral flow path.
    Type: Grant
    Filed: January 30, 2013
    Date of Patent: February 18, 2014
    Assignees: Sorin Group Italia S.r.l., Politecnico di Milano
    Inventors: Stefano Reggiani, Gianfranco Beniamino Fiore, Alberto Redaelli, Christian Baiotto
  • Publication number: 20140030146
    Abstract: An oxygenator includes a housing; a hollow fiber membrane layer that is stored in the housing and has multiple integrated hollow fiber membranes with a gas exchange function; a gas inlet portion and a gas outlet portion that are provided on the upstream and downstream of gas passages in lumens of the hollow fiber membranes, respectively; and a blood inlet portion and a blood outlet portion that are provided on the upstream and downstream of blood passages outsides of the hollow fiber membranes, respectively. The hollow fiber membranes in the hollow fiber membrane layer are fixed relative to each other at one end portion and the other end portion thereof. Conditions 30??60 and OD?4.5×? are met where ? [?m] is an average separation distance between the adjacent hollow fiber membranes at a fixed portion of the hollow fiber membrane layer and OD [?m] is the outer diameter of the hollow fiber membrane.
    Type: Application
    Filed: September 30, 2013
    Publication date: January 30, 2014
    Applicant: TERUMO KABUSHIKI KAISHA
    Inventor: Kazuhiko TAKEUCHI
  • Patent number: 8609022
    Abstract: A medical heat exchanger includes a thin tube bundle 2 in which a plurality of heat transfer thin tubes 1 for letting heat medium liquid flow therethrough are arranged and stacked, seal members 3a to 3c sealing the thin tube bundle while allowing both ends of the heat transfer thin tubes to be exposed and forming a blood channel 5 which allows blood to flow therethrough so that the blood comes into contact with each outer surface of the heat transfer thin tubes; a housing 4 containing the seal members and the thin tube bundle and provided with an inlet port 8 and an outlet port 9 of the blood positioned respectively at both ends of the blood channel; and a pair of heat transfer thin tube headers 6, 7 forming flow chambers 14a, 14b, 15a, 15b that respectively surround both ends of the thin tube bundle and having an inlet port 6a and an outlet port 7a of the heat medium liquid.
    Type: Grant
    Filed: January 22, 2009
    Date of Patent: December 17, 2013
    Assignee: JMS Co., Ltd.
    Inventors: Shota Nakao, Tomokazu Niitsuma, Hideki Izumida
  • Patent number: 8585969
    Abstract: A device for treating blood in an extracorporeal blood circuit, the device including a centrifugal pump provided with a transparent enclosure that is connected, by means of an inlet duct, to the outlet of a venous reservoir, the venous reservoir having an inlet that is connected to receive blood from a patient. The transparent enclosure of the pump is connected monolithically to the base of a structure that comprises a heat exchanger and an oxygenator. The structure also supports monolithically, at the peripheral region, an arterial filter that receives the blood in output from the oxygenator and is provided with a connector for coupling to an arterial line for return of the blood to the patient.
    Type: Grant
    Filed: January 31, 2011
    Date of Patent: November 19, 2013
    Assignee: Sorin Group Italia S.r.l.
    Inventors: Edgardo Costa Maianti, Nicola Ghelli, Ivo Panzani
  • Patent number: 8579845
    Abstract: A capillary tube bundle sub-assembly for use in an extracorporeal heat exchanger includes a continuous capillary tubing wound about a core to define a plurality of capillary layers each including a plurality of capillary segments. The capillary segments each define opposing terminal ends adjacent opposing ends of the core. The capillary segments of each layer are circumferentially aligned relative to an axis of the core, with each successive layer being radially outward of an immediately preceding layer. The capillary segments are non-parallel with the axis, spiraling partially about the axis in extension between the opposing terminal ends. Each capillary segment forms less than one complete revolution (i.e., winds less than 360°). The segments within each layer are substantially parallel with one another; however, an orientation of the segments differs from layer-to-layer such as by pitch or angle.
    Type: Grant
    Filed: January 27, 2011
    Date of Patent: November 12, 2013
    Assignee: Medtronic, Inc.
    Inventors: Patrick Cloutier, Robert Olsen, Stephen Roller, Chris Plott, Al McLevish, Ming Li, Michael Laxen, John Knoll, Gregory Hake
  • Publication number: 20130280692
    Abstract: An integrated perfusion apparatus or device for use in e.g. extracorporeal membrane oxygenation, cardiopulmonary bypass, or isolated organ or limb perfusion, comprises a blood pump for circulating blood through the device; a blood oxygenator for oxygenating blood, and at least one heat control unit capable of controlling and/or regulating blood temperature within the device, wherein the at least one heat control unit comprises at least one solid state heating and/or cooling source, such as at least one Peltier device. The invention also relates to a method of performing perfusion on a patient, limb or organ, comprising using the perfusion device.
    Type: Application
    Filed: July 26, 2011
    Publication date: October 24, 2013
    Applicant: UNIVERSITY OF STRATHCLYDE
    Inventor: Terrence Gourlay
  • Publication number: 20130272924
    Abstract: A modular cooling-heating system for use in the controlled delivery of temperature-controlled fluids to a heat exchanger associated with the blood of a patient undergoing a medical procedure is described, wherein the cooling-heating system uses adaptive temperature control protocols.
    Type: Application
    Filed: March 23, 2012
    Publication date: October 17, 2013
    Applicant: CARDIOQUIP, LLP
    Inventors: Douglas E. Platt, Robin A. Pate, John L. Gardner
  • Patent number: 8545754
    Abstract: Disclosed is an apparatus for oxygenating and controlling the temperature of blood in an extracorporeal circuit. The apparatus has an inlet and an outlet that is located radially outward from the inlet in order to define a flowpath through the apparatus. The apparatus comprises: a core that is substantially centrally located in the apparatus and to which blood from a patient can be supplied through the inlet; a heat exchanger comprising a plurality of heat transfer elements that are arranged around the core and between which blood from the core can move radially outward; and an oxygenator comprising a plurality of gas exchange elements that are arranged around the heat exchanger and between which blood from the heat exchanger can move radially outward before exiting the apparatus through the outlet.
    Type: Grant
    Filed: April 23, 2009
    Date of Patent: October 1, 2013
    Assignee: Medtronic, Inc.
    Inventors: Walt L. Carpenter, Robert W. Olsen, Michael J. Hobday, Alford L. McLevish, Christopher J. Plott, Roderick E. Briscoe, Patrick J. Cloutier, Anil Thapa, Ming Li, Kevin McIntosh, Ken Merte
  • Patent number: 8529834
    Abstract: There is provided a mass exchange apparatus (114) for use in blood/air mass exchange comprising plural blood flow conduits for defining a blood flow from a blood flow inlet provided thereto; and plural air flow conduits for defining an air flow from an air flow inlet provided thereto. The plural air flow conduits and plural blood flow conduits at least partially comprise gas-permeable membrane material, and the conduits are arranged relative to each other such as to enable transfer of oxygen from the air flow to the blood flow and transfer of carbon dioxide from the blood flow to the air flow through the membrane material.
    Type: Grant
    Filed: October 10, 2008
    Date of Patent: September 10, 2013
    Assignee: Haemair Ltd.
    Inventor: Richard William Johns
  • Patent number: 8518259
    Abstract: An apparatus for de-aering, oxygenating and controlling a temperature of blood in an extracorporeal blood circuit. The apparatus includes a housing, a manifold body, a heat exchanger, and an oxygenator. A blood inlet tangentially directs blood into a first chamber of the housing. The manifold body is disposed in a second chamber, and includes a core and a plurality of vanes that define channels. The heat exchanger is arranged around the manifold body, and the oxygenator around the heat exchanger. The channels are open to the heat exchanger. An established blood flow path includes rotational flow within the first chamber to separate air from the blood, generally longitudinal flow from the first chamber and along the channels, and generally radial flow through the heat exchanger and the oxygenator. With this construction, gross air removal occurs prior to the blood passing through the heat exchanger and oxygenator.
    Type: Grant
    Filed: January 27, 2011
    Date of Patent: August 27, 2013
    Assignee: Medtronic, Inc.
    Inventors: Patrick Cloutier, Robert Olsen, Stephen Roller, Chris Plott, Al McLevish, Ming Li, Michael Laxen, John Knoll, Gregory Hake
  • Publication number: 20130209314
    Abstract: An apparatus for oxygenating blood including a housing and an oxygenator bundle. The housing defines a primary chamber, a blood inlet port open to the primary chamber, and a blood outlet region. The outlet region includes a blood outlet port, an outlet chamber open to the outlet port, and a partition. The partition establishes spaced apart, first and second passageways from the primary chamber to the outlet chamber. The oxygenator bundle is disposed within the primary chamber. A blood flow path is formed from the blood inlet port, through the oxygenator bundle and to the blood outlet port, and includes first and second outlet flow paths within the outlet chamber via the first and second passageways, respectively. The first and second outlet blood flow paths merge at the blood outlet port. A dual port blood outlet is created, increasing mixing of blood immediately upstream of the outlet port.
    Type: Application
    Filed: February 15, 2012
    Publication date: August 15, 2013
    Applicant: Medtronic, Inc.
    Inventors: Stephen Roller, Chistopher Plott, Alford McLevish, Gregory Hake, Brian Steffens
  • Patent number: 8496874
    Abstract: An integrated centrifugal blood pump-oxygenator (1) which has a housing (2) with a top (3) having a blood inlet (4), a blood outlet (5) and a gas inlet (6), and a bottom (7) having a rotational body (8) being rotatably arranged in a rotor-housing (9) of the bottom (7). The integrated centrifugal blood pump-oxygenator (1) further has an oxygenator membrane (10) provided in an interior (11) of the housing (2), wherein in the operation state oxygen (12) is transferred from the gas inlet (6) through the oxygenator membrane (10) to a gas outlet (13) and blood (14) is brought in direct contact with the oxygenator membrane (10) by pumping the blood (14) with the rotational body (8) from the blood inlet (4) to the blood outlet (5). The rotational body (8) is magnetically journalled in a contact-free manner with respect to the rotor-housing (9). There is an extracorporeal life support system (1000), and a method of de-bubbling and priming a extracorporeal life support system (1000).
    Type: Grant
    Filed: December 5, 2007
    Date of Patent: July 30, 2013
    Assignee: Thoratec LLC
    Inventors: Barry N. Gellman, Andrew Koert, Zhongjun Wu, Juntao Zhang, Bartley P. Griffith
  • Patent number: 8492160
    Abstract: The invention is a device including array of aciive regions for use in reacting one or more species in at least two of the active regions in a sequential process, e.g., sequential reactions. The device has a transparent substrate member, which has a surface region and a silane material overlying the surface region. A first active region overlies a first portion of the silane material. The first region has a first dimension of less than 1 micron in size and has first molecules capable of binding to the first portion of the silane material. A second active region overlies a second portion of the silane material. The second region has a second dimension of less than 1 micron in size, second molecules capable of binding to the second portion of the active region, and a spatial distance separates the first active region and the second active region.
    Type: Grant
    Filed: March 9, 2010
    Date of Patent: July 23, 2013
    Assignee: The United States of America as Represented by the Administrator of the National Aeronautics and Space Administration
    Inventors: Lawrence A. Wade, Charles Patrick Collier
  • Patent number: 8475398
    Abstract: An extracorporeal blood processing method using a blood circuit comprising a pair of blood passages attached to opposite flow ends of a blood treatment device and said blood circuit is mounted on a blood pump console, the method includes: withdrawing blood from a vascular system of a human patient and drawing the blood into the blood circuit; pumping the withdrawn blood through one of the pair of blood passages using a first blood pump of the console and into the blood treatment device; pumping the treated blood from the treatment device through the other of the pair of blood passages using a second blood pump of the console; infusing the treated blood from the other blood passage and into the vascular system of the patient, and periodically reversing a flow direction of blood through the pair of blood passages and blood treatment device.
    Type: Grant
    Filed: November 6, 2009
    Date of Patent: July 2, 2013
    Assignee: Gambro uf Solutions, Inc.
    Inventor: John O'Mahony
  • Publication number: 20130142695
    Abstract: An oxygenator combines, in a single structure, a heat exchanger, a gas exchanger, an arterial filter, and a filter frame. Such an oxygenator permits fewer fluid connections and thus may simplify an extracorporeal blood circuit, including a heart-lung machine and a blood reservoir, in which it is used. In some embodiments, the oxygenator may be configured to include multiple purge ports for purging bubbles both before and after filtering the blood.
    Type: Application
    Filed: January 25, 2013
    Publication date: June 6, 2013
    Applicants: Politecnico di Milano, Sorin Group Italia S.r.l.
    Inventors: Sorin Group Italia S.r.l., Politecnico di Milano
  • Publication number: 20130142696
    Abstract: A blood processing apparatus may include a heat exchanger and a gas exchanger. At least one of the heat exchanger and the gas exchanger may be configured to impart a radial component to blow flow through the heat exchanger and/or gas exchanger. The heat exchanger may be configured to cause blood flow to follow a spiral flow path.
    Type: Application
    Filed: January 30, 2013
    Publication date: June 6, 2013
    Applicants: Politecnico di Milano, Sorin Group Italia S.r.I.
    Inventors: Sorin Group Italia S.r.I., Politecnico di Milano
  • Publication number: 20120321512
    Abstract: A heat exchanger includes a case, a bottom member and a plurality of heat transfer pipes (a pipe group) loaded in the heat exchanger case, in which blood flows from one end through the bottom member. The bottom member has an annular wall, a bottom surface, and a blood inlet port. The bottom surface is opposed to one end of the heat transfer pipe. The bottom surface includes a groove portion and a raised bottom portion provided on each of opposing end sides of the groove portion. The raised bottom portion is inclined such that a distance between the raised bottom portion on a side where the blood inlet port is provided and one end of the heat transfer pipe is smaller than a distance between the raised bottom portion opposite to the side where the blood inlet port is provided and one end of the heat transfer pipe.
    Type: Application
    Filed: February 15, 2011
    Publication date: December 20, 2012
    Inventors: Shin-ichi Kawamura, Kazuhisa Ishihara, Naoaki Yasumura
  • Publication number: 20120308434
    Abstract: A plurality of heat transfer pipes have a circumferential portion arranged at a short distance from an inner surface of a heat exchanger case while they are bundled to form a pipe group and a first bowstring-shaped portion which retracts toward a center in a direction of cylinder diameter from an arc formed by the circumferential portion. The plurality of bundled heat transfer pipes are loaded in the exchange case such that the first bowstring-shaped portion and an inner surface of the heat exchange case on a side where a heat exchange medium inlet port is attached are opposed to each other. By making a flow of a heat exchange medium to each heat transfer pipe uniform, a heat exchanger capable of obtaining high heat exchange performance is obtained.
    Type: Application
    Filed: February 15, 2011
    Publication date: December 6, 2012
    Inventors: Shin-ichi Kawamura, Kazuhisa Ishihara, Naoaki Yasumura
  • Patent number: 8318092
    Abstract: An oxygenator combines, in a single structure, a heat exchanger, a gas exchanger and an arterial filter. Such an oxygenator permits fewer fluid connections and thus may simplify an extracorporeal blood circuit, including a heart-lung machine and a blood reservoir, in which it is used. In some cases, the oxygenator may be configured to include multiple purge ports for purging bubbles both before and after filtering the blood.
    Type: Grant
    Filed: April 29, 2010
    Date of Patent: November 27, 2012
    Assignee: Sorin Group Italia S.r.l.
    Inventors: Stefano Reggiani, Claudio Silvestri, Alberto Giri
  • Publication number: 20120294761
    Abstract: A blood processing apparatus may include a heat exchanger and a gas exchanger. The heat exchanger may be configured to provide a cross-flow or radially directed blood flow through the heat exchanger.
    Type: Application
    Filed: May 18, 2011
    Publication date: November 22, 2012
    Applicant: Sorin Group Italia S.r.I.
    Inventors: Stefano Reggiani, Claudio Giovannini, Claudio Silvestri, Gabriele Tommasi
  • Patent number: 8292839
    Abstract: A switch comprises a rotating switch member which provides fluid communication in three modes; infusion, recirculation and priming The switch is located between the oxygenator and drug bag and the cardioplegia pump raceway. The switch has three channels molded into the rotating manifold which either direct blood and cardioplegia into the coronary arteries of the patient or into a recirculation line. When the switch is rotated into the recirculation line, a hose is in fluid connection through the switch and connects the recirculation line with the pump blood and drug inlet lines thereby allowing cooling of the cardioplegic mixture during the time between infusions.
    Type: Grant
    Filed: April 9, 2009
    Date of Patent: October 23, 2012
    Inventor: William G. O'Neill
  • Publication number: 20120193289
    Abstract: An apparatus for de-aering, oxygenating and controlling a temperature of blood in an extracorporeal blood circuit. The apparatus includes a housing, a manifold body, a heat exchanger, and an oxygenator. A blood inlet tangentially directs blood into a first chamber of the housing. The manifold body is disposed in a second chamber, and includes a core and a plurality of vanes that define channels. The heat exchanger is arranged around the manifold body, and the oxygenator around the heat exchanger. The channels are open to the heat exchanger. An established blood flow path includes rotational flow within the first chamber to separate air from the blood, generally longitudinal flow from the first chamber and along the channels, and generally radial flow through the heat exchanger and the oxygenator. With this construction, gross air removal occurs prior to the blood passing through the heat exchanger and oxygenator.
    Type: Application
    Filed: January 27, 2011
    Publication date: August 2, 2012
    Applicant: Medtronic, Inc.
    Inventors: Patrick Cloutier, Robert Olsen, Stephen Roller, Chris Plott, Al McLevish, Ming Li, Michael Laxen, John Knoll, Gregory Hake
  • Patent number: 8187216
    Abstract: A hollow fiber bundle that is formed by arranging a plurality of porous hollow fiber membranes 8 in one direction; a heat exchange pipe bundle that is formed by arranging and laminating a plurality of heat exchange pipes 9 in one direction crossing the hollow fiber membranes and is apposed with the hollow fiber bundle; and a potting material 10 that is filled in a region including both end parts of the hollow fiber membranes and the heat exchange pipes and forms a blood channel extending across the hollow fiber membranes and the heat exchange pipes are provided. The housing includes: blood ports 3a, 3b that face both ends of the blood channel; gas headers 4a, 4b that form gas ports 5a, 5b facing both ends of the hollow fiber bundle; and heat exchange headers 6a, 6b that form heat exchange liquid ports 7a, 7b facing both ends of the heat exchange pipe bundle.
    Type: Grant
    Filed: October 20, 2006
    Date of Patent: May 29, 2012
    Assignee: JMS Co., Ltd.
    Inventor: Tomokazu Niitsuma
  • Patent number: 8147753
    Abstract: A heat exchanger includes a plurality of tubes 2 through an inner cavity of which a heat-transfer medium liquid flows, a sealing member 6 that seals the plurality of tubes 2 while exposing both ends thereof, with a blood channel passing outside each of the tubes 2 being formed in a central portion in the axial direction of the tubes, and a housing 5 that accommodates the tubes 2 sealed with the sealing member 6. The heat exchanger further includes a hollow fiber membrane 3 that is formed of a plurality of hydrophobic and gas permeable hollow fibers 4 and that is disposed on at least one of an entrance side and an exit side of the blood channel in the housing 5 so that a liquid flowing through the blood channel passes through the hollow fiber membrane 3. The housing 5 includes openings 10 for exposing open ends of each of the hollow fibers 4 forming the hollow fiber membrane 3 to the outside, and gaps between an inner side of the openings and the hollow fibers 4 are sealed.
    Type: Grant
    Filed: March 28, 2008
    Date of Patent: April 3, 2012
    Assignee: JMS Co., Ltd.
    Inventors: Minoru Tanaka, Tomokazu Niitsuma, Shigeki Kawarabata, Takashi Matsushita
  • Patent number: 8142718
    Abstract: A disposable that is suitable for application in a device for heating a physiological fluid, in particular blood, comprising a conduit for conducting fluid, which conduit comprises conduit sections that are arranged next to each other and bends that connect the conduit section, wherein at least one of the bends comprises a first turbulence-inducing obstruction.
    Type: Grant
    Filed: April 30, 2004
    Date of Patent: March 27, 2012
    Assignee: The Surgical Company International B.V.
    Inventors: Maurice Petrus Wilhelmus Tak, Jeroen Gerbert Hasperhoven
  • Publication number: 20110300020
    Abstract: An oxygenator that inhibits or prevents bubbles in blood from exiting through a blood outlet includes an oxygenator part which performs gas exchange on blood and a heat exchanging part which performs heat exchange on the blood. The oxygenators part has a housing that is generally in a rectangular parallelepiped form, with a hollow fiber membrane bundle positioned in the housing. The hollow fiber membrane bundle is formed by a multiplicity of hollow fiber membranes adapted to perform gas exchange. Blood flows along a blood passage comprised of gaps between the hollow fiber membranes and contacts the surface of the hollow fiber membranes where gas exchange occurs with gas flowing through the lumens of the hollow fiber membranes. In addition, a filter member is arranged on a downstream side of the hollow fiber membrane bundle so that bubbles present in the blood are caught by the filter member.
    Type: Application
    Filed: August 12, 2011
    Publication date: December 8, 2011
    Applicant: TERUMO KABUSHIKI KAISHA
    Inventor: Mitsuaki OGIHARA
  • Patent number: 8070952
    Abstract: The invention relates to an apparatus and method for simultaneous extrarenal blood purification therapy and respiration support therapy. The apparatus includes a CO2 removing means having a first inlet for receiving a flow of blood for CO2 removal and a first outlet for expelling blood deprived of CO2. The apparatus also includes filtering means having a first inlet for receiving the flow of blood, a first outlet for expelling purified blood, and at least one drain channel. The drain channel directs a diluting liquid obtained from the blood expelled during purification of the blood. The drain channel is directly connected to the first inlet of the CO2 removing means to supply the diluting liquid to the CO2 removing means without submitting the diluting liquid to any filtering treatment during passage along the drain channel.
    Type: Grant
    Filed: April 30, 2008
    Date of Patent: December 6, 2011
    Assignee: Medical Service S.R.L.
    Inventor: Gianni Pasqualini
  • Patent number: 8057095
    Abstract: Device for adapting a temperature probe for a use in a port in a heart-lung machine. An adaptor slip is tapered at an adaptor taper angle less than a port taper angle. The adaptor slip is sized such that the exterior wall of the adaptor slip provides an interference fit with at least a portion of the fluid port. The adaptor slip has an external shoulder abutting the end of the fluid port. The adaptor slip additionally has a sleeve having a closed end having a position with respect to the end of the adapter slip. A probe is configured to be seated in a lumen of the adaptor slip with a proximate end of the probe being proximate to the closed end of said sleeve.
    Type: Grant
    Filed: April 23, 2009
    Date of Patent: November 15, 2011
    Assignee: Medtronic, Inc.
    Inventor: Mark Wendler
  • Publication number: 20110268609
    Abstract: An oxygenator combines, in a single structure, a heat exchanger, a gas exchanger, an arterial filter, and a filter frame. Such an oxygenator permits fewer fluid connections and thus may simplify an extracorporeal blood circuit, including a heart-lung machine and a blood reservoir, in which it is used. In some embodiments, the oxygenator may be configured to include multiple purge ports for purging bubbles both before and after filtering the blood.
    Type: Application
    Filed: October 6, 2010
    Publication date: November 3, 2011
    Applicants: Politecnico di Milano, Sorin Group Italia S.r.l.
    Inventors: Stefano Reggiani, Claudio Silvestri, Alberto Giri, Alberto Redaelli, Gianfranco Beniamino Fiore
  • Publication number: 20110125074
    Abstract: A device for treating blood in an extracorporeal blood circuit, the device including a centrifugal pump provided with a transparent enclosure that is connected, by means of an inlet duct, to the outlet of a venous reservoir, the venous reservoir having an inlet that is connected to receive blood from a patient. The transparent enclosure of the pump is connected monolithically to the base of a structure that comprises a heat exchanger and an oxygenator. The structure also supports monolithically, at the peripheral region, an arterial filter that receives the blood in output from the oxygenator and is provided with a connector for coupling to an arterial line for return of the blood to the patient.
    Type: Application
    Filed: January 31, 2011
    Publication date: May 26, 2011
    Applicant: Sorin Group Italia S.r.l.
    Inventors: Edgardo Costa Maianti, Nicola Ghelli, Ivo Panzani
  • Publication number: 20100290947
    Abstract: A medical heat exchanger includes a thin tube bundle 2 in which a plurality of heat transfer thin tubes 1 for letting heat medium liquid flow therethrough are arranged and stacked, seal members 3a to 3c sealing the thin tube bundle while allowing both ends of the heat transfer thin tubes to be exposed and forming a blood channel 5 which allows blood to flow therethrough so that the blood comes into contact with each outer surface of the heat transfer thin tubes; a housing 4 containing the seal members and the thin tube bundle and provided with an inlet port 8 and an outlet port 9 of the blood positioned respectively at both ends of the blood channel; and a pair of heat transfer thin tube headers 6, 7 forming flow chambers 14a, 14b, 15a, 15b that respectively surround both ends of the thin tube bundle and having an inlet port 6a and an outlet port 7a of the heat medium liquid.
    Type: Application
    Filed: January 22, 2009
    Publication date: November 18, 2010
    Applicant: JMS CO., LTD.
    Inventors: Shota Nakao, Tomokazu Niitsuma, Hideki Izumida
  • Publication number: 20100272606
    Abstract: Described is an apparatus for oxygenating and controlling the temperature of blood in an extracorporeal circuit comprising: an inlet mandrel that is configured such that the blood moves radially outward from the inlet mandrel through the openings in a radial direction; a heat exchanger arranged around the inlet mandrel, wherein blood can move radially outward with the transfer of heat to or from the blood; an oxygenator arranged around the heat exchanger, wherein blood can move from the heat exchanger radially outward with the transfer of oxygen into the blood; and a housing that houses the inlet mandrel, the heat exchanger and the oxygenator, and that comprises a blood inlet in communication with the inlet mandrel in order to allow blood to enter the apparatus from the patient, and a blood outlet in communication with the oxygenator in order for blood to exit the apparatus, wherein the blood outlet is located in the housing radially outward from the inlet.
    Type: Application
    Filed: April 23, 2009
    Publication date: October 28, 2010
    Inventors: Walt L. Carpenter, Robert W. Olsen, Michael J. Hobday, Alford L. McLevish, Christopher J. Plott, Roderick E. Briscoe, Partick J. Cloutier, Anil Thapa, Ming Li, Kevin McInotosh