Blood Treating Device For Transfusible Blood Patents (Class 422/44)
  • Patent number: 11376350
    Abstract: Fluid management in surgical procedures. At least some of the example embodiments are methods including: pumping surgical fluid through a tube to a surgical site by a fluid controller operating in a first mode, the first mode comprising a first relationship of fluid flow and pressure drop across the tube and cannula, and the first mode comprising a first set of proportional, integral, and differential (PID) parameters; and then pumping surgical fluid through the tube to the surgical site with the fluid controller operating in a second mode, the second mode comprising a second relationship of fluid flow and pressure drop across the tube and cannula, the second relationship different than the first relationship, and the second mode comprising a second set of PID parameters used, the second set of PID parameters different than the first set of PID parameters.
    Type: Grant
    Filed: October 22, 2018
    Date of Patent: July 5, 2022
    Assignee: SMITH & NEPHEW, INC.
    Inventors: Jonathan L. Gaspredes, Jean Woloszko, Rajitha Aluru, David J. Miller
  • Patent number: 11344851
    Abstract: A biological fluid separation device adapted to receive a biological fluid sample having a first portion and a second portion is disclosed. The device includes a housing having a first chamber having a first chamber inlet for receiving the biological fluid sample therein and a first chamber outlet. The housing has a second chamber having a second chamber inlet and a second chamber outlet, and a separation member separating at least a portion of the first chamber outlet and the second chamber. The separation member is adapted to restrain the first portion of the biological fluid sample within the first chamber and to allow at least a portion of the second portion of the biological fluid sample to pass into the second chamber. An actuator, such as a vacuum source, draws the biological fluid sample into the first chamber and the second portion into the second chamber.
    Type: Grant
    Filed: October 21, 2019
    Date of Patent: May 31, 2022
    Assignee: BECTON, DICKINSON AND COMPANY
    Inventors: Qihua Xu, Kristin Weidemaier, Christopher Basciano, Sivaramakrishnan Balasubramanian, Patrick Downie
  • Patent number: 11318235
    Abstract: Extracorporeal blood treatment apparatus with reservoir status lights and methods of monitoring reservoir status using the same are described. The extracorporeal blood treatment apparatus include a plurality of reservoir scales (30), each of which is configured to weigh a reservoir (32) used in connection with the extracorporeal blood treatment apparatus. A plurality of reservoir status lights (40) are provided, with one or more of the reservoir status lights (40) associated with one of the reservoir scales (30). The one or more reservoir status lights (40) associated with one of the reservoir scales (30) emit light from a location that is closer to their associated reservoir scale than to any other reservoir scale of the extracorporeal blood treatment apparatus.
    Type: Grant
    Filed: July 23, 2018
    Date of Patent: May 3, 2022
    Assignee: Gambro Lundia AB
    Inventor: John O'Mahony
  • Patent number: 11305103
    Abstract: A housing having an interior and an exterior. A pump rotor is configured to be received within the interior of the housing, the pump rotor includes a magnet. A stator having a delivery configuration and an operative configuration is included, the stator in the delivery configuration has a delivery diameter, the stator in the operative configuration being configured to be disposed around the exterior of the housing and to form an assembled pump having a diameter greater than the delivery diameter.
    Type: Grant
    Filed: January 3, 2020
    Date of Patent: April 19, 2022
    Assignee: HeartWare, Inc.
    Inventors: Jeffrey A. Larose, Gill B. Bearnson, Stanley P. Mack, Charles R. Shambaugh
  • Patent number: 11305241
    Abstract: A biological fluid separation device adapted to receive a biological fluid sample having a first portion and a second portion is disclosed. The device includes a housing having a first chamber having a first chamber inlet for receiving the biological fluid sample therein and a first chamber outlet. The housing has a second chamber having a second chamber inlet and a second chamber outlet, and a separation member separating at least a portion of the first chamber outlet and the second chamber. The separation member is adapted to restrain the first portion of the biological fluid sample within the first chamber and to allow at least a portion of the second portion of the biological fluid sample to pass into the second chamber. An actuator, such as a vacuum source, draws the biological fluid sample into the first chamber and the second portion into the second chamber.
    Type: Grant
    Filed: October 21, 2019
    Date of Patent: April 19, 2022
    Assignee: BECTON, DICKINSON AND COMPANY
    Inventors: Qihua Xu, Kristin Weidemaier, Christopher Basciano, Sivaramakrishnan Balasubramanian, Patrick Downie
  • Patent number: 11291930
    Abstract: A reserve tank has a container, an outlet component, and an inlet component. The outlet component and the inlet component are mounted on the container. The outlet component has an open end located at a center of the container. The inlet component has a branch portion mounted in the container and an inlet channel in the branch portion. Therefore, when the reserve tank is disposed obliquely, even though the reserve tank is not full of a working liquid and contains some gas, the gas can hardly flow into the open end of the outlet component. In addition, if some gas enters the container through the inlet channel and thus forms bubbles, the bubbles may move upward along part of the branch tunnels extending upward, so the entering bubbles are still far from the open end.
    Type: Grant
    Filed: September 10, 2018
    Date of Patent: April 5, 2022
    Assignee: Cooler Master Co., Ltd.
    Inventors: Hsin-Hung Chen, Geeng Jieh Chong
  • Patent number: 11219551
    Abstract: Methods and for treatment of cancer and other diseases including complications from late stage viral infections by inducing hyperthermia in a patient relying on withdrawing blood from the patient and returning the withdrawn blood to the patient to establish an extracorporeal flow circuit. Blood is heated by passing through the extracorporeal circuit at a controlled rate until a target body core temperature in is achieved. Usually, the blood will be subjected to a continuously re-circulating dialysis to balance electrolytes. Additionally, the blood will be subjected to a continuously recirculating regeneration through a carbon sorbent column where toxins and contaminants are removed. The blood temperature is maintained at the target blood temperature for a treatment period, and the blood is cooled after the treatment period has been completed.
    Type: Grant
    Filed: April 25, 2021
    Date of Patent: January 11, 2022
    Inventors: Roger Vertrees, Jan Winetz
  • Patent number: 11191883
    Abstract: Methods and for treatment of cancer and other diseases including complications from late stage viral infections by inducing hyperthermia in a patient relying on withdrawing blood from the patient and returning the withdrawn blood to the patient to establish an extracorporeal flow circuit. Blood is heated by passing through the extracorporeal circuit at a controlled rate until a target body core temperature in is achieved. Usually, the blood will be subjected to a continuously re-circulating dialysis to balance electrolytes. Additionally, the blood will be subjected to a continuously recirculating regeneration through a carbon sorbent column where toxins and contaminants are removed. The blood temperature is maintained at the target blood temperature for a treatment period, and the blood is cooled after the treatment period has been completed.
    Type: Grant
    Filed: June 23, 2021
    Date of Patent: December 7, 2021
    Inventors: Roger Vertrees, Jan Winetz
  • Patent number: 11185622
    Abstract: Methods and for treatment of cancer and other diseases including complications from late stage viral infections by inducing hyperthermia in a patient relying on withdrawing blood from the patient and returning the withdrawn blood to the patient to establish an extracorporeal flow circuit. Blood is heated by passing through the extracorporeal circuit at a controlled rate until a target body core temperature in is achieved. Usually, the blood will be subjected to a continuously re-circulating dialysis to balance electrolytes. Additionally, the blood will be subjected to a continuously recirculating regeneration through a carbon sorbent column where toxins and contaminants are removed. The blood temperature is maintained at the target blood temperature for a treatment period, and the blood is cooled after the treatment period has been completed.
    Type: Grant
    Filed: February 14, 2021
    Date of Patent: November 30, 2021
    Inventors: Roger Vertrees, Jan Winetz
  • Patent number: 11179550
    Abstract: Systems, methods, and devices are provided for the treatment of edema. In one aspect a method for implanting an indwelling catheter within a vein of a patient is provided. The catheter can extend from a position upstream of at least one outflow port of a duct of the lymph system to a terminal position downstream of the at least one outflow port. In use, a first restriction can be created within the vein proximal to a distal region of the catheter. The first restriction can define a localized low pressure zone distal of the restriction and within a portion of the vein housing the catheter. The low pressure zone can be adjacent to the at least one outflow port to enable fluid to pass from the at least one lymph duct outflow port into the vein.
    Type: Grant
    Filed: December 19, 2018
    Date of Patent: November 23, 2021
    Assignee: White Swell Medical Ltd
    Inventors: Yaacov Nitzan, Menashe Yacoby, Tanhum Feld
  • Patent number: 11160957
    Abstract: An apparatus and method for preventing stroke by occluding blood flow through the carotid arteries and a left subclavian artery of a patient is provided. The apparatus has a first occluding catheter that carries a first occluding balloon that has an inflated configuration that occludes one of the carotid arteries. The apparatus also includes a second occluding catheter that carries a second occluding balloon that has an inflated configuration that occludes the other one of the carotid arteries. A third occluding balloon is present, that could be on an insertion device, that may occlude the left subclavian artery.
    Type: Grant
    Filed: December 19, 2018
    Date of Patent: November 2, 2021
    Inventor: Michael Zhadkevich
  • Patent number: 11083830
    Abstract: A fluid conduit includes a first portion having a first porosity, a second portion disposed immediately adjacent to the first portion, the second portion having a second porosity that is greater than the first porosity, and a third portion of the fluid conduit disposed immediately adjacent to the second portion, the third portion having a third porosity that is less than the second porosity. Each of the first portion, the second portion, and the third portion may be integrally formed as a single, continuous piece defining the fluid conduit.
    Type: Grant
    Filed: October 14, 2019
    Date of Patent: August 10, 2021
    Assignee: Fresenius Medical Care Holdings, Inc.
    Inventor: Claudy J. Mullon
  • Patent number: 11065375
    Abstract: A blood oxygenator is disclosed comprising a housing, a blood inlet, a blood outlet, a spiral volute, a gas inlet, an oxygenator fiber bundle, and a gas outlet. The housing encloses the fiber bundle and provides the structure for the blood flow path and connectors. The fiber bundle comprises gas-exchange membranes which transfer oxygen to the blood and remove carbon dioxide when the blood flows across the membranes. The spiral volute guides the blood to flow through the fiber bundle. A gas flow chamber receives sweep gas containing oxygen and distributes the sweep gas into the fiber membranes, which gas is then exchanged with the blood being oxygenated.
    Type: Grant
    Filed: December 17, 2018
    Date of Patent: July 20, 2021
    Assignee: UNIVERSITY OF MARYLAND, BALTIMORE
    Inventors: Zhongjun Wu, Bartley P. Griffith
  • Patent number: 11065379
    Abstract: Methods and for treatment of cancer and other diseases including complications from late stage viral infections by inducing hyperthermia in a patient relying on withdrawing blood from the patient and returning the withdrawn blood to the patient to establish an extracorporeal flow circuit. Blood is heated by passing through the extracorporeal circuit at a controlled rate until a target body core temperature in is achieved. Usually, the blood will be subjected to a continuously re-circulating dialysis to balance electrolytes. Additionally, the blood will be subjected to a continuously recirculating regeneration through a carbon sorbent column where toxins and contaminants are removed. The blood temperature is maintained at the target blood temperature for a treatment period, and the blood is cooled after the treatment period has been completed.
    Type: Grant
    Filed: April 11, 2020
    Date of Patent: July 20, 2021
    Assignee: VERYHERMIA ACQUISTION, INC.
    Inventors: Roger Vertrees, Jan Winetz
  • Patent number: 11013845
    Abstract: The present invention is a UV light box, systems, and methods for irradiating plasma.
    Type: Grant
    Filed: July 17, 2020
    Date of Patent: May 25, 2021
    Inventor: Noshi Ishak
  • Patent number: 11013842
    Abstract: An oxygenator unit adapted for use in an extracorporeal blood treatment device. The oxygenator unit includes an oxygenator having a gas inlet and a supply line for conducting a gas provided at the gas inlet, the supply line being connectable to a source of a pressurized gas containing oxygen, wherein the oxygenator unit further includes a pressure relief valve provided in the supply line upstream of the oxygenator, the pressure relief valve adapted to release pressure exceeding a predetermined pressure value from the supply line, thereby preventing a critical overpressure in the oxygenator.
    Type: Grant
    Filed: July 9, 2018
    Date of Patent: May 25, 2021
    Assignee: B. BRAUN AVITUM AG
    Inventor: Jörn Ahrens
  • Patent number: 11013771
    Abstract: Methods and compositions for improved clinical outcomes for trauma patients receiving whole blood transfusion. Methods and compositions for improved clinical outcomes for blood transfusions for cancer patients are also provided.
    Type: Grant
    Filed: May 18, 2016
    Date of Patent: May 25, 2021
    Assignee: Hemanext Inc.
    Inventor: Tatsuro Yoshida
  • Patent number: 10993828
    Abstract: An extracorporeal blood cooling or heating circuit includes an intravenous catheter for withdrawing a patient's blood coupled to a combined pump/heat exchanger device. One or more sensors are provided upstream and/or downstream of the pump/heat exchanger device for measuring pressure, temperature, fluid flow, blood oxygenation, and other parameters. A controller is operatively coupled to the pump/heat exchanger device and the one or more sensors to control the speed of the pump inside the pump/heat exchanger device and regulate the blood temperature by controlling the operation of the heat exchanger. The combined pump/heat exchanger device includes a housing having at least one inlet and at least one outlet, a pump portion defining a blood circuit inside the housing, and a heat exchanger portion contained within the housing for selectively heating or cooling the blood.
    Type: Grant
    Filed: November 23, 2016
    Date of Patent: May 4, 2021
    Assignee: CardiacAssist, Inc.
    Inventors: Robert G. Svitek, Kraig J. McEwen, Rebecca L. Baptiste Davenport
  • Patent number: 10989706
    Abstract: A plasma separation system and process for providing filtered plasma from a blood sample is described. The system may include a blood separation well having a separation membrane for filtering the blood sample. The filtering process may be aided by the use of a negative or positive pressure source attached to the plasma separation system.
    Type: Grant
    Filed: July 30, 2015
    Date of Patent: April 27, 2021
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Michael S. Wilson, Jay Li, Kenneth P. Galano
  • Patent number: 10881343
    Abstract: A device includes a pre-sample reservoir, an actuator mechanism, and a diverter. The pre-sample reservoir can be fluidically coupled to a delivery member to receive and isolate a predetermined volume of bodily-fluid withdrawn from a patient. The actuator mechanism is operably coupled to the pre-sample reservoir such that, when actuated, a negative pressure is formed in the pre-sample reservoir that urges the bodily-fluid to flow into the pre-sample reservoir. The diverter can selectively control fluid flow between the delivery member and the pre-sample reservoir. The diverter includes a flow control mechanism that defines a first fluid flow path and a second fluid flow path. The diverter is movable between a first configuration in which the bodily-fluid flows through the first fluid flow path to the pre-sample reservoir, and a second configuration in which the bodily-fluid flows through the second fluid flow path to a sample reservoir coupled to the diverter.
    Type: Grant
    Filed: October 29, 2015
    Date of Patent: January 5, 2021
    Assignee: Magnolia Medical Technologies, Inc.
    Inventors: Gregory J. Bullington, Richard G. Patton, Jay M. Miazga, Shan E. Gaw
  • Patent number: 10881347
    Abstract: A method of performing closed-loop dialysis treatment during hemodialysis is provided. The method involves determining an initial ultrafiltration rate and setting an ultrafiltration pump of a dialysis system to the determined ultrafiltration rate. A series of measurements and calculations are made to ensure that a rate of change of blood volume during treatment follows a specified profile. A threshold may be used to keep the rate of change of blood volume tracking the profile. Patient fluid dynamics may be measured in real-time and used to determine the ultrafiltration pump rate.
    Type: Grant
    Filed: March 21, 2018
    Date of Patent: January 5, 2021
    Assignee: Fresenius Medical Care Holdings, Inc.
    Inventors: Louis L. Barrett, Ken Chhi, David Yuds, Tom Merics, Joan Dowd
  • Patent number: 10792410
    Abstract: This document provides bioartificial liver (BAL) devices. Methods for making and using BAL devices also are provided.
    Type: Grant
    Filed: October 25, 2018
    Date of Patent: October 6, 2020
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Scott L. Nyberg, Stephen M. Corner, Bruce Amiot
  • Patent number: 10788463
    Abstract: The present invention relates to a device and a method for dynamic fractionation of a dispersed phase in a fluid. The device comprises a fractionation channel and from a first to a third injection ports. A first and a second confining fluids are injectable through the first and second injection ports, respectively. An elution fluid for transporting the dispersed phase is injectable into the channel through a third injection port which is arranged between the first and second injection ports. An end portion of the channel comprises from a first to a third terminal portion respectively arranged in correspondence to the first to the third injection ports and having a geometry such that the first and second confining fluids respectively have a first and second predefined flow rate and the elution fluid have a third predefined flow rate which is larger than the first and second predefined flow rates.
    Type: Grant
    Filed: August 14, 2015
    Date of Patent: September 29, 2020
    Inventor: Martina Di Venere
  • Patent number: 10712245
    Abstract: A filtration system for a liquid comprising a container (2) having an internal container volume (11), a particulate filter portion (10) for allowing passage of the liquid into the internal container volume (11) to forma liquid sample aliquot and a first opening (14) providing access to the internal container volume (11); the filtration system further comprising a non-porous housing (4) configured to provide an internal space (28) for receiving the container (2), the internal space (28) being dimensioned to provide a volume such that the amount left unoccupied by the received container (2) is less than the internal container volume (11).
    Type: Grant
    Filed: December 16, 2014
    Date of Patent: July 14, 2020
    Assignee: Foss Analytical A/S
    Inventors: Henrik Thomsen, Christian Michelsen
  • Patent number: 10603417
    Abstract: A system and methodology for the preservation of red blood cells is described in which red blood cells are oxygen or oxygen and carbon dioxide depleted, treated and are stored in an anaerobic environment to optimize preparation for transfusion. More particularly, a system and method for extended storage of red blood cells from collection to transfusion that optimizes red blood cells prior to transfusion is described.
    Type: Grant
    Filed: November 13, 2017
    Date of Patent: March 31, 2020
    Assignee: Hemanext Inc.
    Inventors: Tatsuro Yoshida, Paul Vernucci
  • Patent number: 10471186
    Abstract: Systems and methods for providing for the automatic instrument-based rapid reprocessing of an intact extracorporeal circuit for use in hemodialysis. The system includes a manifold with connectors for engaging a dialyzer as well as venous and arterial blood lines. The manifold is adapted to be moved from a dialysis machine to a reuse instrument without removing the dialyzer and associated blood lines. The system allows for reprocessing of the extracorporeal circuit wherein prior to the next treatment, there is no residual chemical disinfectant requiring testing, the extracorporeal circuit is pre-primed, the levels in the bubble traps are set, and all of the required quality assurance tests are performed and recorded.
    Type: Grant
    Filed: April 3, 2017
    Date of Patent: November 12, 2019
    Assignees: Baxter International Inc., Baxter Healthcare SA
    Inventor: Rodney S. Kenley
  • Patent number: 10413655
    Abstract: An oxygen supply unit for use with a blood oxygenator comprises an oxygen concentrator and a carbon dioxide scrubber. In an on-line operational mode, oxygen-rich gas from the oxygen concentrator is predominantly supplied to the blood oxygenator with a reduced flow of recycled gas from the concentrator. In an off-line operational mode where the oxygen supply unit is being powered by battery only, a larger flow of recycled gas from the blood oxygenator is passed through the carbon dioxide scrubber and combined with a lesser amount of oxygen-rich gas from the oxygen concentrator. The oxygen supply unit may be used in combination with a blood pump and oxygenator to provide ambulatory blood oxygenation to patients with compromised lung function.
    Type: Grant
    Filed: May 18, 2017
    Date of Patent: September 17, 2019
    Assignees: UNIVERSITY OF MARYLAND, BALTIMORE, BREETHE, INC
    Inventors: Zhongjun Wu, Bartley Griffith, David N. Wells
  • Patent number: 10406258
    Abstract: A hollow fiber membrane bundle configured to be used in an artificial lung and comprised of integrated hollow fiber membranes 31 has hollow portions through which a fluid passes. The hollow fiber membrane bundle is shaped as a cylinder body. In addition, the hollow fiber membrane 31 is tilted with respect to a central axis O of the cylinder body, is wound around the central axis O of the cylinder body, and satisfies the following conditions. An inner diameter ?d1 of the hollow fiber membrane 31 is equal to or smaller than 150 ?m, a tilt angle ? with respect to the central axis O of the cylinder body of the hollow fiber membrane 31 is equal to or smaller than 60°, and a ratio ?D1/L of an outer diameter ?D1 of the cylinder body to a length L of the cylinder body is equal to or greater than 0.4.
    Type: Grant
    Filed: January 24, 2017
    Date of Patent: September 10, 2019
    Assignee: TERUMO KABUSHIKI KAISHA
    Inventor: Eisuke Sasaki
  • Patent number: 10391226
    Abstract: A process includes removing air bubbles from extracorporeal blood via chemical entrapment of nitrogen (N2) gas.
    Type: Grant
    Filed: February 7, 2017
    Date of Patent: August 27, 2019
    Assignee: International Business Machines Corporation
    Inventors: Sarah K. Czaplewski, Joseph Kuczynski, Jason T. Wertz, Jing Zhang
  • Patent number: 10342905
    Abstract: A fluid flow system for a patient is disclosed. A fluid drive module includes a fluid drive element, a housing, and a chamber located between the housing and the fluid drive element. A controller or control module modifies the speed of the fluid drive element during use, such as to prevent thrombus or otherwise improve flow conditions. Methods of alternating fluid flow are also provided.
    Type: Grant
    Filed: September 4, 2013
    Date of Patent: July 9, 2019
    Assignee: CircuLite, Inc.
    Inventors: Wolfgang Kerkhoffs, Oliver Marseille, Michael Martin, Robert C. Farnan, John P. Budris, J. Christopher Flaherty
  • Patent number: 10254300
    Abstract: An analyzer is disclosed. The analyzer comprises a rack slot configured to receive at least one rack, wherein the rack slot comprises a front end, at which the rack is manually loadable into the rack slot, and a rear end, which is opposite to the front end and at which the rack is fully receivable in the rack slot, and a spring device arranged at the rear end, wherein the spring device is configured to provide a biasing force towards the front end, wherein the biasing force is adapted to move the rack towards the front end if not fully received in the rack slot, wherein the spring device is configured to fix the rack in a final position if the rack is fully received in the rack slot. Further, a method for loading a rack into a rack slot of an analyzer and a system comprising an analyzer and a computer controller are disclosed.
    Type: Grant
    Filed: April 26, 2017
    Date of Patent: April 9, 2019
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Armin Birrer, Rolf Frey, Christian Marty, André Peter, Marco Sangermano
  • Patent number: 10246506
    Abstract: Methods for reduction of aggregate levels in antibody and other protein preparations through treatment with low concentrations of electropositive organic additives (e.g., ethacridine, chlorhexidine, or polyethylenimine) in combination with ureides (e.g., urea, uric acid, or allantoin) or organic modulators (e.g., nonionic organic polymers, surfactants, organic solvent or ureides). Some aspects of the invention relate to methods for reducing the level of aggregates in conjunction with clarification of cell culture harvest. It further relates to the integration of these capabilities with other purification methods to achieve the desired level of final purification.
    Type: Grant
    Filed: November 26, 2014
    Date of Patent: April 2, 2019
    Assignee: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
    Inventor: Peter Gagnon
  • Patent number: 10197558
    Abstract: An environmental sampling and assay system, utilizing coupons, and having an assay coupon wetting and monitoring assembly adapted to perform an assay on a coupon. The system also includes a coupon storage assembly and a coupon moving assembly, adapted to move a coupon from the coupon storage assembly to the coupon wetting and monitoring assembly. Further, the coupon storage assembly includes a first coupon magazine storing a set of first-shaped coupons and a second coupon magazine storing a set of second-shaped coupons, different in shape from the first-shaped coupons, and wherein the coupon moving assembly includes a first moveable coupon carrier, positioned to receive coupons from the first magazine, that is shaped to hold first-shaped coupons and a second moveable coupon carrier, positioned to receive coupons from the second magazine and that is shaped to hold second-shaped coupons.
    Type: Grant
    Filed: September 18, 2017
    Date of Patent: February 5, 2019
    Assignee: CBRN INTERNATIONAL, LTD
    Inventors: Elric Saaski, Robert Fay Livingston, Duane M. Fox
  • Patent number: 10195405
    Abstract: Systems, methods, and devices are provided for the treatment of edema. In one aspect a method for implanting an indwelling catheter within a vein of a patient is provided. The catheter can extend from a position upstream of at least one outflow port of a duct of the lymph system to a terminal position downstream of the at least one outflow port. In use, a first restriction can be created within the vein proximal to a distal region of the catheter. The first restriction can define a localized low pressure zone distal of the restriction and within a portion of the vein housing the catheter. The low pressure zone can be adjacent to the at least one outflow port to enable fluid to pass from the at least one lymph duct outflow port into the vein.
    Type: Grant
    Filed: March 28, 2017
    Date of Patent: February 5, 2019
    Assignee: White Swell Medical Ltd
    Inventors: Yaacov Nitzan, Menashe Yacoby, Tanhum Feld
  • Patent number: 10139319
    Abstract: A sample smearing apparatus of an embodiment includes: a first slide glass feeder that feeds a slide glass before processing; a slide glass transporter including a slide glass holder that holds the slide glass, that is capable of receiving the slide glass at a first slide glass feeding position from the first slide glass feeder, and transports the received slide glass while holding the slide glass with the slide glass holder; and a slide processor that performs processing on the slide glass held by the slide glass holder.
    Type: Grant
    Filed: April 27, 2017
    Date of Patent: November 27, 2018
    Assignee: SYSMEX CORPORATION
    Inventors: Shogo Kubota, Mitsuo Yamasaki, Seiya Shinabe
  • Patent number: 10080834
    Abstract: A extracorporeal system for lung assist includes a housing, a blood flow inlet in fluid connection with the housing; a blood flow outlet in fluid connection with the housing; a plurality of hollow gas permeable fibers adapted to permit diffusion of gas between blood and an interior of the hollow gas permeable fibers, the plurality of hollow gas permeable fibers being positioned between the blood flow inlet and the blood flow outlet such that blood flows around the plurality of hollow gas permeable fibers when flowing from the blood flow inlet to the blood flow outlet; a gas inlet in fluid connection with the housing and in fluid connection with inlets of the plurality of hollow gas permeable fibers; a gas outlet in fluid connection with the housing and in fluid connection with outlets of the plurality of hollow gas permeable fibers; and at least one moving element to create velocity fields in blood flow contacting the plurality of hollow gas permeable fibers.
    Type: Grant
    Filed: November 27, 2013
    Date of Patent: September 25, 2018
    Assignees: University of Pittsburgh—Of the Commonwealth System of Higher Education, CARNEGIE MELLON UNIVERSITY
    Inventors: William J. Federspiel, Brian Joseph Frankowski, James F. Antaki, Christian Andres Bermudez, Richard Garrett Jeffries, William R. Wagner, Sang-Ho Ye
  • Patent number: 10061899
    Abstract: A home therapy machine is configured to perform a home therapy on a patient at a home or dwelling of the patient. The home therapy machine includes at least one processor operating a connectivity agent having an activated mode and a deactivated mode. When the connectivity agent is in the activated mode, the at least one processor is able to send data to and receive data from a system hub. When the connectivity agent is in the deactivated mode, the at least one processor is not able to send data to or receive data from the system hub. The home therapy machine further includes a user interface configured to receive a patient selection of a device program received from the system hub and at least one pump under control of the at least one processor for performing the home therapy according to the selected device program.
    Type: Grant
    Filed: April 17, 2017
    Date of Patent: August 28, 2018
    Assignees: Baxter International Inc., Baxter Healthcare SA
    Inventors: Joshua James Miller, Derek Wiebenson, Douglas L. Wilkerson, Neil Tiwari, Timothy G. Robinson, Marc Steven Minkus, Matthew R. Muller, Anders J. Wellings, Kathryn Louise Hansbro, Borut Cizman, Brian S. Kunzeman, Robin D. Cooper, Timothy L. Kudelka, Angelo A. Sarto, Steve Joseph Lindo, Jostein Baustad, Duston Mounts, Shafali Hill
  • Patent number: 9827365
    Abstract: Methods and systems are provided automatically removing air from a collection container for a blood product. The system comprises a disposable flow circuit including a tubing in fluid communication with the collection container and a durable hardware component. A programmable controller operates the pump in a first/forward direction to flow the target product into the collection container; determines that substantially all the target product has been pumped into the collection container; and operates the pump in the first/forward direction to pump a chase volume of air into the collection container along with any target product remaining in the tubing. In one embodiment, after the chase volume of air is pumped into the collection container, the controller operates the pump in a second/reverse direction for removing air from the collection container, and stops operation of the pump when the amount of air removed from the collection container is substantially equal to the residual volume of air.
    Type: Grant
    Filed: September 8, 2016
    Date of Patent: November 28, 2017
    Assignee: Fenwal, Inc.
    Inventors: Kyungyoon Min, Katherine N. Radwanski, Tanima Jahan Abedin
  • Patent number: 9801784
    Abstract: A blood storage container for the anaerobic storage of blood, having enhanced sealing methods and materials for the preservation of stored blood is provided.
    Type: Grant
    Filed: March 31, 2017
    Date of Patent: October 31, 2017
    Assignee: New Health Sciences, Inc.
    Inventors: Tatsuro Yoshida, Rafael Cordero, Jancarlo Sarita, Michael Zocchi, Michael Wolf, Philip Michael Keegan, Narendran Renganathan, Jeffrey Karl Sutton
  • Patent number: 9782279
    Abstract: Devices, systems, and methods for autoretroperfusion.
    Type: Grant
    Filed: November 18, 2014
    Date of Patent: October 10, 2017
    Assignee: CVDevices, LLC
    Inventor: Ghassan S. Kassab
  • Patent number: 9770545
    Abstract: A method and system for collecting a double volume of red blood cells using a spinning membrane separator is provided by which a first quantity of whole blood is withdrawn from a donor; a first quantity of whole blood is flowed to the spinning membrane separator; where it is separated into a first quantity of red blood cells and a first quantity of plasma. The first quantity of red blood cells and the first quantity of plasma are then flowed to respective collection containers, and at least a portion of the first quantity of plasma is returned to the donor. A second quantity of whole blood withdrawn from the donor, and then separated into a second quantity of red blood cells and a second quantity of plasma using the spinning membrane separator. The second quantity of red blood cells and the second quantity of plasma are then flowed to the respective collection containers, and at least a portion of the second quantity of plasma is returned to the donor.
    Type: Grant
    Filed: June 9, 2016
    Date of Patent: September 26, 2017
    Assignee: Fenwal, Inc.
    Inventors: Benjamin Kusters, Kyungyoon Min, Christopher Wegener, William H. Cork
  • Patent number: 9724460
    Abstract: Disclosed is a system to generate bubbles. The bubbles may be formed to include a substantially or medically pure gas. The bubbles may be formed on demand and in a selected small size.
    Type: Grant
    Filed: March 25, 2014
    Date of Patent: August 8, 2017
    Assignee: Oakwood Healthcare, Inc.
    Inventor: James Richard Spears
  • Patent number: 9637724
    Abstract: A method of selectively separating a biological target from a sample including the biological target material or suspected of including the biological target includes the steps of (i) providing a solid including ureide moieties at its surface, (ii) contacting the sample with the solid, whereby a substantial fraction of the biological target in the sample binds to the ureide moieties, and (iii) separating the solid from the sample.
    Type: Grant
    Filed: November 26, 2014
    Date of Patent: May 2, 2017
    Assignee: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
    Inventor: Peter Gagnon
  • Patent number: 9629358
    Abstract: Described are systems and methods for monitoring administration of nitric oxide (NO) to ex vivo fluids. Examples of such fluids include blood in extracorporeal membrane oxygenation (ECMO) circuits or perfusion fluids used for preserving ex vivo organs prior to transplanting in a recipient. The systems and methods described herein provide for administering nitric oxide to the fluid, monitoring nitric oxide or a nitric oxide marker in the fluid, and adjusting the nitric oxide administration.
    Type: Grant
    Filed: December 3, 2013
    Date of Patent: April 25, 2017
    Assignee: Mallinckrodt Hospital Products IP Limited
    Inventors: Jim Potenziano, Douglas R. Hansell, Jeff Griebel, Eddie Costa, Lisa Cooper
  • Patent number: 9618505
    Abstract: The invention generally provides two-component molecular biosensors. In particular, the invention provides molecular biosensors having peptide epitope binding agents that bind a target antibody. The molecular biosensors are useful in several methods including in the identification and quantification of target molecules.
    Type: Grant
    Filed: February 16, 2015
    Date of Patent: April 11, 2017
    Assignee: MEDIOMICS, LLC
    Inventors: Tomasz Heyduk, Ling Tian, Rongsheng E. Wang, Yie-Hwa Chang
  • Patent number: 9616162
    Abstract: Systems and methods for providing for the automatic instrument-based rapid reprocessing of an intact extracorporeal circuit for use in hemodialysis. The system includes a manifold with connectors for engaging a dialyzer as well as venous and arterial blood lines. The manifold is adapted to be moved from a dialysis machine to a reuse instrument without removing the dialyzer and associated blood lines. The system allows for reprocessing of the extracorporeal circuit wherein prior to the next treatment, there is no residual chemical disinfectant requiring testing, the extracorporeal circuit is pre-primed, the levels in the bubble traps are set, and all of the required quality assurance tests are performed and recorded.
    Type: Grant
    Filed: September 20, 2013
    Date of Patent: April 11, 2017
    Assignees: Baxter International Inc., Baxter Healthcare SA
    Inventor: Rodney S. Kenley
  • Patent number: 9549953
    Abstract: The invention is directed to the removal of serum gal-3 from circulation by plasmapheresis, comprising at least in part donor apheresis, using gal-3 binding agents in either a fixed bed, or in a form easily removed, such as by being complexed with magnetic particles. This method, on its own, brings a sharp reduction and relief from the inflammation and fibroses that can be induced by circulating gal-3. The process may be combined with the administration of gal-3 binding agents, such as modified citrus pectin, to further lower unbound gal-3 levels, to the point where gal-3 in the tissues may be addressed. This method may also be combined with removal of TNF receptors to provide an effective treatment for cancer.
    Type: Grant
    Filed: December 27, 2013
    Date of Patent: January 24, 2017
    Assignee: Eliaz Therapeutics, Inc.
    Inventor: Isaac Eliaz
  • Patent number: 9413018
    Abstract: A hollow fiber membrane module is disclosed. In particular, technology for achieving a reduction in pressure deviation of channels generated when an external fluid passes through a case, thereby achieving a uniform flow rate of the fluid through each channel.
    Type: Grant
    Filed: September 17, 2013
    Date of Patent: August 9, 2016
    Assignee: KOLON INDUSTRIES, INC.
    Inventors: Jin Hyung Lee, Kyoung Ju Kim, Young Seok Oh, Moo Seok Lee
  • Patent number: 9364604
    Abstract: A user interface for a machine for extracorporeal blood treatment comprises a touch screen and a controller programmed to display on a screen (16) a display in which two distinct areas are arranged, one of which (161) exhibits a series of touch keys (17). Activation of any one touch key (17) causes visualization of an image in a second area (162) of the screen. The images are displayed alternatively and are at least partly different one from another. Each touch key (17) is associated to an instruction, or to a group of instructions, all concerned with readying the machine for use. Each image is a pictograph of a configuration of the machine, correlated with an instruction associated to the touch key (17) selected. The operator is aided in making the machine ready for treatment.
    Type: Grant
    Filed: June 17, 2011
    Date of Patent: June 14, 2016
    Assignee: Gambro Lundia AB
    Inventors: Lorenza Ferrarini, Danielle Pelletier, Massimo Zaccarelli, Jeffrey J. Letteri
  • Patent number: 9216246
    Abstract: A renal failure therapy method includes causing therapy fluid to flow to a renal failure therapy filter, directing at least twenty-five percent of the therapy fluid to the renal failure therapy filter to perform conductive clearance, and using the renal therapy failure filter to cause at least a substantial amount of the remaining therapy fluid to perform diffusive clearance.
    Type: Grant
    Filed: September 30, 2011
    Date of Patent: December 22, 2015
    Assignees: Baxter International Inc., Baxter Healthcare S.A.
    Inventors: Thomas Kelly, Robert W. Childers, Don Busby, Rodolfo Roger, Waleed Mutasem El Sayyid, Shahid Din