Blood Treating Device For Transfusible Blood Patents (Class 422/44)
  • Patent number: 10254300
    Abstract: An analyzer is disclosed. The analyzer comprises a rack slot configured to receive at least one rack, wherein the rack slot comprises a front end, at which the rack is manually loadable into the rack slot, and a rear end, which is opposite to the front end and at which the rack is fully receivable in the rack slot, and a spring device arranged at the rear end, wherein the spring device is configured to provide a biasing force towards the front end, wherein the biasing force is adapted to move the rack towards the front end if not fully received in the rack slot, wherein the spring device is configured to fix the rack in a final position if the rack is fully received in the rack slot. Further, a method for loading a rack into a rack slot of an analyzer and a system comprising an analyzer and a computer controller are disclosed.
    Type: Grant
    Filed: April 26, 2017
    Date of Patent: April 9, 2019
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Armin Birrer, Rolf Frey, Christian Marty, André Peter, Marco Sangermano
  • Patent number: 10246506
    Abstract: Methods for reduction of aggregate levels in antibody and other protein preparations through treatment with low concentrations of electropositive organic additives (e.g., ethacridine, chlorhexidine, or polyethylenimine) in combination with ureides (e.g., urea, uric acid, or allantoin) or organic modulators (e.g., nonionic organic polymers, surfactants, organic solvent or ureides). Some aspects of the invention relate to methods for reducing the level of aggregates in conjunction with clarification of cell culture harvest. It further relates to the integration of these capabilities with other purification methods to achieve the desired level of final purification.
    Type: Grant
    Filed: November 26, 2014
    Date of Patent: April 2, 2019
    Assignee: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
    Inventor: Peter Gagnon
  • Patent number: 10197558
    Abstract: An environmental sampling and assay system, utilizing coupons, and having an assay coupon wetting and monitoring assembly adapted to perform an assay on a coupon. The system also includes a coupon storage assembly and a coupon moving assembly, adapted to move a coupon from the coupon storage assembly to the coupon wetting and monitoring assembly. Further, the coupon storage assembly includes a first coupon magazine storing a set of first-shaped coupons and a second coupon magazine storing a set of second-shaped coupons, different in shape from the first-shaped coupons, and wherein the coupon moving assembly includes a first moveable coupon carrier, positioned to receive coupons from the first magazine, that is shaped to hold first-shaped coupons and a second moveable coupon carrier, positioned to receive coupons from the second magazine and that is shaped to hold second-shaped coupons.
    Type: Grant
    Filed: September 18, 2017
    Date of Patent: February 5, 2019
    Assignee: CBRN INTERNATIONAL, LTD
    Inventors: Elric Saaski, Robert Fay Livingston, Duane M. Fox
  • Patent number: 10195405
    Abstract: Systems, methods, and devices are provided for the treatment of edema. In one aspect a method for implanting an indwelling catheter within a vein of a patient is provided. The catheter can extend from a position upstream of at least one outflow port of a duct of the lymph system to a terminal position downstream of the at least one outflow port. In use, a first restriction can be created within the vein proximal to a distal region of the catheter. The first restriction can define a localized low pressure zone distal of the restriction and within a portion of the vein housing the catheter. The low pressure zone can be adjacent to the at least one outflow port to enable fluid to pass from the at least one lymph duct outflow port into the vein.
    Type: Grant
    Filed: March 28, 2017
    Date of Patent: February 5, 2019
    Assignee: White Swell Medical Ltd
    Inventors: Yaacov Nitzan, Menashe Yacoby, Tanhum Feld
  • Patent number: 10139319
    Abstract: A sample smearing apparatus of an embodiment includes: a first slide glass feeder that feeds a slide glass before processing; a slide glass transporter including a slide glass holder that holds the slide glass, that is capable of receiving the slide glass at a first slide glass feeding position from the first slide glass feeder, and transports the received slide glass while holding the slide glass with the slide glass holder; and a slide processor that performs processing on the slide glass held by the slide glass holder.
    Type: Grant
    Filed: April 27, 2017
    Date of Patent: November 27, 2018
    Assignee: SYSMEX CORPORATION
    Inventors: Shogo Kubota, Mitsuo Yamasaki, Seiya Shinabe
  • Patent number: 10080834
    Abstract: A extracorporeal system for lung assist includes a housing, a blood flow inlet in fluid connection with the housing; a blood flow outlet in fluid connection with the housing; a plurality of hollow gas permeable fibers adapted to permit diffusion of gas between blood and an interior of the hollow gas permeable fibers, the plurality of hollow gas permeable fibers being positioned between the blood flow inlet and the blood flow outlet such that blood flows around the plurality of hollow gas permeable fibers when flowing from the blood flow inlet to the blood flow outlet; a gas inlet in fluid connection with the housing and in fluid connection with inlets of the plurality of hollow gas permeable fibers; a gas outlet in fluid connection with the housing and in fluid connection with outlets of the plurality of hollow gas permeable fibers; and at least one moving element to create velocity fields in blood flow contacting the plurality of hollow gas permeable fibers.
    Type: Grant
    Filed: November 27, 2013
    Date of Patent: September 25, 2018
    Assignees: University of Pittsburgh—Of the Commonwealth System of Higher Education, CARNEGIE MELLON UNIVERSITY
    Inventors: William J. Federspiel, Brian Joseph Frankowski, James F. Antaki, Christian Andres Bermudez, Richard Garrett Jeffries, William R. Wagner, Sang-Ho Ye
  • Patent number: 10061899
    Abstract: A home therapy machine is configured to perform a home therapy on a patient at a home or dwelling of the patient. The home therapy machine includes at least one processor operating a connectivity agent having an activated mode and a deactivated mode. When the connectivity agent is in the activated mode, the at least one processor is able to send data to and receive data from a system hub. When the connectivity agent is in the deactivated mode, the at least one processor is not able to send data to or receive data from the system hub. The home therapy machine further includes a user interface configured to receive a patient selection of a device program received from the system hub and at least one pump under control of the at least one processor for performing the home therapy according to the selected device program.
    Type: Grant
    Filed: April 17, 2017
    Date of Patent: August 28, 2018
    Assignees: Baxter International Inc., Baxter Healthcare SA
    Inventors: Joshua James Miller, Derek Wiebenson, Douglas L. Wilkerson, Neil Tiwari, Timothy G. Robinson, Marc Steven Minkus, Matthew R. Muller, Anders J. Wellings, Kathryn Louise Hansbro, Borut Cizman, Brian S. Kunzeman, Robin D. Cooper, Timothy L. Kudelka, Angelo A. Sarto, Steve Joseph Lindo, Jostein Baustad, Duston Mounts, Shafali Hill
  • Patent number: 9827365
    Abstract: Methods and systems are provided automatically removing air from a collection container for a blood product. The system comprises a disposable flow circuit including a tubing in fluid communication with the collection container and a durable hardware component. A programmable controller operates the pump in a first/forward direction to flow the target product into the collection container; determines that substantially all the target product has been pumped into the collection container; and operates the pump in the first/forward direction to pump a chase volume of air into the collection container along with any target product remaining in the tubing. In one embodiment, after the chase volume of air is pumped into the collection container, the controller operates the pump in a second/reverse direction for removing air from the collection container, and stops operation of the pump when the amount of air removed from the collection container is substantially equal to the residual volume of air.
    Type: Grant
    Filed: September 8, 2016
    Date of Patent: November 28, 2017
    Assignee: Fenwal, Inc.
    Inventors: Kyungyoon Min, Katherine N. Radwanski, Tanima Jahan Abedin
  • Patent number: 9801784
    Abstract: A blood storage container for the anaerobic storage of blood, having enhanced sealing methods and materials for the preservation of stored blood is provided.
    Type: Grant
    Filed: March 31, 2017
    Date of Patent: October 31, 2017
    Assignee: New Health Sciences, Inc.
    Inventors: Tatsuro Yoshida, Rafael Cordero, Jancarlo Sarita, Michael Zocchi, Michael Wolf, Philip Michael Keegan, Narendran Renganathan, Jeffrey Karl Sutton
  • Patent number: 9782279
    Abstract: Devices, systems, and methods for autoretroperfusion.
    Type: Grant
    Filed: November 18, 2014
    Date of Patent: October 10, 2017
    Assignee: CVDevices, LLC
    Inventor: Ghassan S. Kassab
  • Patent number: 9770545
    Abstract: A method and system for collecting a double volume of red blood cells using a spinning membrane separator is provided by which a first quantity of whole blood is withdrawn from a donor; a first quantity of whole blood is flowed to the spinning membrane separator; where it is separated into a first quantity of red blood cells and a first quantity of plasma. The first quantity of red blood cells and the first quantity of plasma are then flowed to respective collection containers, and at least a portion of the first quantity of plasma is returned to the donor. A second quantity of whole blood withdrawn from the donor, and then separated into a second quantity of red blood cells and a second quantity of plasma using the spinning membrane separator. The second quantity of red blood cells and the second quantity of plasma are then flowed to the respective collection containers, and at least a portion of the second quantity of plasma is returned to the donor.
    Type: Grant
    Filed: June 9, 2016
    Date of Patent: September 26, 2017
    Assignee: Fenwal, Inc.
    Inventors: Benjamin Kusters, Kyungyoon Min, Christopher Wegener, William H. Cork
  • Patent number: 9724460
    Abstract: Disclosed is a system to generate bubbles. The bubbles may be formed to include a substantially or medically pure gas. The bubbles may be formed on demand and in a selected small size.
    Type: Grant
    Filed: March 25, 2014
    Date of Patent: August 8, 2017
    Assignee: Oakwood Healthcare, Inc.
    Inventor: James Richard Spears
  • Patent number: 9637724
    Abstract: A method of selectively separating a biological target from a sample including the biological target material or suspected of including the biological target includes the steps of (i) providing a solid including ureide moieties at its surface, (ii) contacting the sample with the solid, whereby a substantial fraction of the biological target in the sample binds to the ureide moieties, and (iii) separating the solid from the sample.
    Type: Grant
    Filed: November 26, 2014
    Date of Patent: May 2, 2017
    Assignee: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
    Inventor: Peter Gagnon
  • Patent number: 9629358
    Abstract: Described are systems and methods for monitoring administration of nitric oxide (NO) to ex vivo fluids. Examples of such fluids include blood in extracorporeal membrane oxygenation (ECMO) circuits or perfusion fluids used for preserving ex vivo organs prior to transplanting in a recipient. The systems and methods described herein provide for administering nitric oxide to the fluid, monitoring nitric oxide or a nitric oxide marker in the fluid, and adjusting the nitric oxide administration.
    Type: Grant
    Filed: December 3, 2013
    Date of Patent: April 25, 2017
    Assignee: Mallinckrodt Hospital Products IP Limited
    Inventors: Jim Potenziano, Douglas R. Hansell, Jeff Griebel, Eddie Costa, Lisa Cooper
  • Patent number: 9618505
    Abstract: The invention generally provides two-component molecular biosensors. In particular, the invention provides molecular biosensors having peptide epitope binding agents that bind a target antibody. The molecular biosensors are useful in several methods including in the identification and quantification of target molecules.
    Type: Grant
    Filed: February 16, 2015
    Date of Patent: April 11, 2017
    Assignee: MEDIOMICS, LLC
    Inventors: Tomasz Heyduk, Ling Tian, Rongsheng E. Wang, Yie-Hwa Chang
  • Patent number: 9616162
    Abstract: Systems and methods for providing for the automatic instrument-based rapid reprocessing of an intact extracorporeal circuit for use in hemodialysis. The system includes a manifold with connectors for engaging a dialyzer as well as venous and arterial blood lines. The manifold is adapted to be moved from a dialysis machine to a reuse instrument without removing the dialyzer and associated blood lines. The system allows for reprocessing of the extracorporeal circuit wherein prior to the next treatment, there is no residual chemical disinfectant requiring testing, the extracorporeal circuit is pre-primed, the levels in the bubble traps are set, and all of the required quality assurance tests are performed and recorded.
    Type: Grant
    Filed: September 20, 2013
    Date of Patent: April 11, 2017
    Assignees: Baxter International Inc., Baxter Healthcare SA
    Inventor: Rodney S. Kenley
  • Patent number: 9549953
    Abstract: The invention is directed to the removal of serum gal-3 from circulation by plasmapheresis, comprising at least in part donor apheresis, using gal-3 binding agents in either a fixed bed, or in a form easily removed, such as by being complexed with magnetic particles. This method, on its own, brings a sharp reduction and relief from the inflammation and fibroses that can be induced by circulating gal-3. The process may be combined with the administration of gal-3 binding agents, such as modified citrus pectin, to further lower unbound gal-3 levels, to the point where gal-3 in the tissues may be addressed. This method may also be combined with removal of TNF receptors to provide an effective treatment for cancer.
    Type: Grant
    Filed: December 27, 2013
    Date of Patent: January 24, 2017
    Assignee: Eliaz Therapeutics, Inc.
    Inventor: Isaac Eliaz
  • Patent number: 9413018
    Abstract: A hollow fiber membrane module is disclosed. In particular, technology for achieving a reduction in pressure deviation of channels generated when an external fluid passes through a case, thereby achieving a uniform flow rate of the fluid through each channel.
    Type: Grant
    Filed: September 17, 2013
    Date of Patent: August 9, 2016
    Assignee: KOLON INDUSTRIES, INC.
    Inventors: Jin Hyung Lee, Kyoung Ju Kim, Young Seok Oh, Moo Seok Lee
  • Patent number: 9364604
    Abstract: A user interface for a machine for extracorporeal blood treatment comprises a touch screen and a controller programmed to display on a screen (16) a display in which two distinct areas are arranged, one of which (161) exhibits a series of touch keys (17). Activation of any one touch key (17) causes visualization of an image in a second area (162) of the screen. The images are displayed alternatively and are at least partly different one from another. Each touch key (17) is associated to an instruction, or to a group of instructions, all concerned with readying the machine for use. Each image is a pictograph of a configuration of the machine, correlated with an instruction associated to the touch key (17) selected. The operator is aided in making the machine ready for treatment.
    Type: Grant
    Filed: June 17, 2011
    Date of Patent: June 14, 2016
    Assignee: Gambro Lundia AB
    Inventors: Lorenza Ferrarini, Danielle Pelletier, Massimo Zaccarelli, Jeffrey J. Letteri
  • Patent number: 9216246
    Abstract: A renal failure therapy method includes causing therapy fluid to flow to a renal failure therapy filter, directing at least twenty-five percent of the therapy fluid to the renal failure therapy filter to perform conductive clearance, and using the renal therapy failure filter to cause at least a substantial amount of the remaining therapy fluid to perform diffusive clearance.
    Type: Grant
    Filed: September 30, 2011
    Date of Patent: December 22, 2015
    Assignees: Baxter International Inc., Baxter Healthcare S.A.
    Inventors: Thomas Kelly, Robert W. Childers, Don Busby, Rodolfo Roger, Waleed Mutasem El Sayyid, Shahid Din
  • Patent number: 9211370
    Abstract: A renal therapy blood cleansing system is provided. The renal therapy blood cleansing system includes a blood filtering device in fluid communication with a blood circuit, a balance chamber configured to exchange like volumes of fresh and used therapy fluid with the blood filtering device, a first pump configured to pump fresh fluid to the balance chamber, a second pump positioned and arranged to receive used fluid from the blood filtering device, and a control scheme. The control scheme is programmed to isolate the blood filtering device from the second pump and deliver a volume of fresh fluid to the blood filtering device via the balance chamber while the second pump is isolated from the blood filtering device, so as to increase fluid volume within the blood circuit.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: December 15, 2015
    Assignees: Baxter International Inc., Baxter Healthcare S.A.
    Inventors: Thomas D. Kelly, Waleed M. El Sayyid
  • Patent number: 9186100
    Abstract: An apparatus for performing phlebotomy through a peripheral intravenous line. The apparatus includes an introducer and a catheter configured to advance the catheter through a peripheral intravenous line. A y-adapter with a port of larger diameter is configured to receive the catheter and place in fluid communication with the peripheral intravenous line. When advanced the catheter is configured to transport a bodily fluid (i.e. blood) to a volume outside of the body.
    Type: Grant
    Filed: September 16, 2011
    Date of Patent: November 17, 2015
    Assignee: Velano Vascular, Inc.
    Inventor: Pitamber Devgon
  • Publication number: 20150146500
    Abstract: An apparatus for extracting at least one blood component contained in a primary bag of a system of bags, said system of bags comprising at least one bag of solution containing an additive solution for said blood component and at least one collecting satellite bag configured to collect said blood component to which said additive solution has been added, said bags being connected to one another by tubes, said apparatus comprising an extraction device configured to extract the blood component by compressing the primary bag, and a control device configured to transfer said extracted component or of said extracted component and of the additive solution, to the collecting satellite bag by the intermediary of tubes, further comprising: an agitation device, and a drive system, said system being designed to enable the uniform mixing of the extracted blood component and of the additive solution in said collecting satellite bag.
    Type: Application
    Filed: July 4, 2013
    Publication date: May 28, 2015
    Inventors: Tony Schroeder, Massimo Racanelli
  • Publication number: 20150132312
    Abstract: The present invention generally relates to systems and methods for targeted removal of a substance or biomolecule such as a protein from a biological fluid, such as blood. In some cases, the blood may be withdrawn from a subject, treated, and returned to the subject. Previous techniques for removal of biological materials from blood, such as hemodialysis and plasmapheresis, were generally non-specific (i.e., they removed a multitude of proteins/toxins from the blood). By contrast, novel methods and devices described herein are capable of removing specific or single substances such as proteins from biological fluids such as blood in a specific manner. Such highly specific protein removal has a broad array of clinical applications, including treatment of inflammatory conditions and autoimmune diseases.
    Type: Application
    Filed: March 14, 2013
    Publication date: May 14, 2015
    Applicant: Children's Medical Center Corporation
    Inventors: James B. McAlvin, Boaz Mizrahi, Daniel S. Kohane, Ryan G. Wylie
  • Patent number: 9024746
    Abstract: An automatic locking system for a medical treatment device helps to ensure that an assistant is present during treatment of a patient. Among the features disclosed biometric authentication to verify that a trained assistant is present, a presence detector to ensure the assistant is continuously present during treatment, and warning and recovery processes that allow intermittent lapses in the continuous presence of the assistant.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: May 5, 2015
    Assignee: Nxstage Medical, Inc.
    Inventors: Jeffrey H. Burbank, Dennis M. Treu, James M. Brugger
  • Publication number: 20150118109
    Abstract: Disclosed herein are centrifuge-free self-contained systems for aseptically separating components of whole blood comprising at least one cassette for receiving whole blood; at least one red blood cell exclusion filter; at least one leukocyte reduction filters; at least one platelet exclusion filter; a plurality of product cassettes; and optionally a plurality of pumps and valves; and wherein the filters, pumps, valves, and cassettes are fluidly connected by tubing and the system does not include a centrifuge. Also disclosed are methods for obtaining blood components using the system.
    Type: Application
    Filed: December 4, 2014
    Publication date: April 30, 2015
    Inventors: Christopher D. Hillyer, Beth H. Shaz
  • Patent number: 9011768
    Abstract: A device for oxygenating blood during extracorporeal circulation includes a box-like body having a first end and a second end opposite thereto and defining therebetween a treatment chamber with an inner surface. The device further includes, in the treatment chamber, at least one exchange unit having at least one flat diaphragm that is impervious to blood and has a major axis and a minor axis. The diaphragm has a winding of hollow microporous fibers. The device further includes an inlet port and an outlet port axially aligned with one another in an alignment direction. A compartment is provided for accumulation and delivery of blood to be treated, another compartment for collecting treated blood, the compartments being located downstream of the inlet port and upstream of the outlet port, between the exchange unit and the inner surface of the treatment chamber. The diaphragm is disposed with the major axis parallel to the alignment direction.
    Type: Grant
    Filed: June 28, 2011
    Date of Patent: April 21, 2015
    Assignee: Rand, S.R.L.
    Inventor: Daniele Galavotti
  • Patent number: 9011769
    Abstract: A blood reservoir may be used in combination with other elements such as a heart lung machine (HLM), oxygenator, heat exchanger, arterial filter and the like to form an extracorporeal blood circuit that may be employed in a procedure such as a bypass procedure. The blood reservoir may be configured to receive, filter and store blood from a number of sources including vent blood (from within the heart), venous blood (from a major vein), purge blood (from a sampling line) and cardiotomy or suction blood (from the surgical field).
    Type: Grant
    Filed: July 13, 2011
    Date of Patent: April 21, 2015
    Assignee: Sorin Group Italia S.r.l.
    Inventors: Claudio Silvestri, Gabriele Tommasi
  • Patent number: 9011766
    Abstract: A method for increasing the shelf life of donor blood contemplates the following steps. In the first step blood is transferred to a sterile container and mixed with an anticoagulant as indicated in step 20. The anticoagulant and donor blood are centrifuged in step 22 at about 4,000 rpm for about 15 minutes. After centrifuging the red blood cells are separated and placed in a sterile tube. In the next step the red blood cells are irradiated by a laser that emanates a wavelength of about 633 nm for a time period of about 24 hours. During rotation the RBCs are rotated to provide uniform exposure. Such laser biostimulation produces an enhancement of shelf life of donor blood by 66%.
    Type: Grant
    Filed: November 19, 2012
    Date of Patent: April 21, 2015
    Assignee: King Saud University
    Inventors: Al-Khalid Isam Zuhaier, Mohamad Saleh AlSalhi, Vadivel Masilamani
  • Publication number: 20150099800
    Abstract: The invention provides for novel lipase inhibitors, and compositions and devices comprising the same. The invention further provides for methods for treatment of disorders comprising administration of novel diacylglycerol lipase inhibitors, and compositions and devices comprising said inhibitors. In some embodiments, the disorders are pancreatitis, obesity, shock or pancreatic necrosis. The invention further provides for novel ether lipid reporter compounds and methods of assaying enzymatic activity comprising contacting a compound with a novel ether lipid reporter compound.
    Type: Application
    Filed: May 24, 2013
    Publication date: April 9, 2015
    Inventor: Richard I. Duclos, JR.
  • Publication number: 20150093289
    Abstract: The present invention relates to a method for using lectins that bind to pathogens having high mannose surface glycoproteins or fragments thereof which contain high mannose glycoproteins, to remove them from infected blood or plasma in an extracorporeal setting. Accordingly, the present invention provides a method for reducing viral load in an individual comprising the steps of obtaining blood or plasma from the individual, passing the blood or plasma through a porous hollow fiber membrane wherein lectin molecules are immobilized within the porous exterior portion of the membrane, collecting pass-through blood or plasma and reinfusing the pass-through blood or plasma into the individual.
    Type: Application
    Filed: September 18, 2014
    Publication date: April 2, 2015
    Inventor: Richard H. Tullis
  • Publication number: 20150080849
    Abstract: A method of treating blood withdrawn from patient including: simultaneously withdrawing blood and infusing withdrawn blood from and to the patient by flowing the withdrawn blood through an extracorporeal dialysis circuit including a dialyzer having a semi-permeable dialysis membrane and a dialysate side adjacent the membrane; feeding a dialysate containing 1 to 5 mM total calcium and 2 to 8 mM citrate to the dialysate side of the dialyzer, and introducing an anticoagulation fluid including at least 8 mM citrate into the
    Type: Application
    Filed: November 25, 2014
    Publication date: March 19, 2015
    Inventor: Jan Sternby
  • Patent number: 8980176
    Abstract: A blood processing apparatus may include a heat exchanger and a gas exchanger. The heat exchanger may be configured to provide a cross-flow or radially directed blood flow through the heat exchanger.
    Type: Grant
    Filed: May 18, 2011
    Date of Patent: March 17, 2015
    Assignee: Sorin Group Italia S.r.l.
    Inventors: Stefano Reggiani, Claudio Giovannini, Claudio Silvestri, Gabriele Tommasi
  • Patent number: 8968232
    Abstract: Embodiments of the present invention relate generally to heat-exchanger systems that can be used to heat or cool a fluid such as blood. Pod pumps that provide low shear and low turbulence may be used in such systems, particularly for systems that pump blood. A certain heat-exchanger system used to heat blood or other fluids may be used to provide whole-body hyperthermic treatments or regional hyperthermic chemotherapy treatments. A disposable unit may be used to separate the fluid path from the fluid control systems. The disposable unit typically includes a heat-exchanger component that is received by a corresponding heat exchanger in a base unit. Fluid pumped through the heat-exchanger component is heated by the heat exchanger.
    Type: Grant
    Filed: January 31, 2011
    Date of Patent: March 3, 2015
    Assignee: DEKA Products Limited Partnership
    Inventors: Dean Kamen, Jason A. Demers, David E. Altobelli, Larry B. Gray, N. Christopher Perry, Brian Tracey, James D. Dale, Dirk A. van der Merwe, Kingston Owens
  • Patent number: 8945037
    Abstract: A blood purification apparatus has a dialyzer (1), an arterial blood circuit (2) with a blood pump 4, a venous blood circuit 3, a dialysate introduction line L1, a dialysate discharge line L2, a substitution line L3, and a substitution pump 9 that supplies the dialysate flowing in the substitution line L3 to the arterial blood circuit 2. A control device (11) estimates or measures the concentration of blood in a dilution channel section A. The control device (11) controls the volume of dialysate supplied by the substitution pump 9 on the basis of the estimated or measured blood concentration.
    Type: Grant
    Filed: September 24, 2012
    Date of Patent: February 3, 2015
    Assignee: Nikkiso Company Limited
    Inventors: Shinya Hasegawa, Masahiro Toyoda
  • Patent number: 8921339
    Abstract: Apparatus for contacting body fluids with the bio-affinity material is disclosed. The apparatus includes a container having top and bottom lock covers that clip onto the container.
    Type: Grant
    Filed: August 15, 2007
    Date of Patent: December 30, 2014
    Assignee: Glycorex Transplantation AB
    Inventor: Kurt Nilsson
  • Patent number: 8915875
    Abstract: The invention relates to a device and a method for depletion of hepcidin from blood for treatment of iron deficiency, in particular in anemic patients suffering from chronic renal failure, with the goal of increasing the availability of iron in the body and thus improving the treatment of the anemia. The hepcidin adsorbent comprises a matrix and a hepcidin-binding ligand covalently bonded to the matrix with an affinity having a dissociation constant KD of less than 200 nM.
    Type: Grant
    Filed: July 15, 2010
    Date of Patent: December 23, 2014
    Assignee: Fresenius Medical Care Deutschland GmbH
    Inventors: Jutta Passlick-Deetjen, Wolfgang Hofmann
  • Patent number: 8906300
    Abstract: A blood oxygenator includes an integral pneumatic pump disposed substantially within a housing thereof, an inlet blood flow redirector, and an outflow blood collector. An atrium provided at an inlet of the oxygenator promotes even delivery of blood to the oxygenator. In use, the oxygenator provides an even dispersion of blood therethrough, establishing even perfusion and reducing areas of stagnant blood flow.
    Type: Grant
    Filed: August 13, 2012
    Date of Patent: December 9, 2014
    Assignee: The University of Kentucky Research Foundation
    Inventors: Dongfang Wang, Joseph B. Zwischenberger
  • Publication number: 20140356851
    Abstract: A method for the re-anticoagulation of platelet rich plasma in a blood apheresis system includes priming the blood apheresis system with anticoagulant, such that a volume of anticoagulant is transferred to a PRP container. The method may then transfer the anticoagulant within the PRP container to a red blood cell container, and collect a volume of platelet rich plasma within the PRP container. The platelet rich plasma may be collected in a plurality of cycles. Between collection cycles, the method may transfer a portion of the volume of anticoagulant from the red blood cell container to the PRP container.
    Type: Application
    Filed: August 14, 2014
    Publication date: December 4, 2014
    Inventors: Etienne Pagès, Michael Ragusa
  • Patent number: 8865003
    Abstract: A method for separating, or removing, particulate material, e.g., blood cells, from a sample of fluid, e.g., whole blood of a patient, in which the particulate material is suspended. In the case of separating blood cells from blood plasma or blood serum, the resulting samples of blood plasma or blood serum can be used for in vitro diagnostic applications. In normal practice, a whole blood sample of a patient are provided and then introduced into an apparatus that contains a flow channel. An acoustic field, which contains acoustic standing waves from external ultrasonic transducers, is located within the flow channel. Laminar flow is maintained in the flow channel. Blood cells and platelets are separated from blood plasma or blood serum at the end of the flow channel and collected. The method described herein allows fluid components to differentially migrate to areas of preferred acoustic interaction.
    Type: Grant
    Filed: September 26, 2008
    Date of Patent: October 21, 2014
    Assignee: Abbott Laboratories
    Inventor: Tahua Yang
  • Publication number: 20140294672
    Abstract: An example of a nitric oxide delivery device includes a medium, a working electrode in contact with the medium, and a reference/counter electrode in contact with the medium and electrically isolated from the working electrode. The medium includes a source of nitrite ions and a Cu(II)-ligand complex. A nitric oxide permeable material separates the medium from an external environment that is to contain blood.
    Type: Application
    Filed: December 7, 2013
    Publication date: October 2, 2014
    Applicant: The Regents of the University of Michigan
    Inventors: Mark E. Meyerhoff, Lajos Hofler, Dipankar Koley, Hang Ren
  • Publication number: 20140294671
    Abstract: The invention provides an improved apparatus and methods for carrying out cardiopulmonary bypass. In particular, the invention relates to pericardial blood suction apparatus and methods, which can be carried out during cardiopulmonary bypass procedures.
    Type: Application
    Filed: October 25, 2012
    Publication date: October 2, 2014
    Inventors: John Wallace Mulholland, Paul Joseph Malone, Gary Christian Cordery
  • Publication number: 20140287436
    Abstract: A system and method for analyzing a sample of liquid having an NMR signal in response to a magnetic field for the presence of an analyte. Included is an NMR device having a testing section that is adapted to contain a liquid and apply a magnetic field to the liquid. A complex comprised of a conjugate having a field gradient bound to the analyte that is of sufficient magnitude to quench the NMR signal of the liquid, when in the test section whereby the presence of the complex is determined by the absence of the NMR signal. The system and method also include a container having a binding agent therein that has an affinity for the analyte or foreign agent that is used to remove the foreign agent from a patient's blood or plasma. Blood or plasma is shunted through the container to remove or reduce the foreign agent by extracorporeal circulation.
    Type: Application
    Filed: June 6, 2014
    Publication date: September 25, 2014
    Inventor: Laurel Sillerud
  • Publication number: 20140271356
    Abstract: The venous reservoir is omitted from an extracorporeal blood circuit system by substituting a blood reservoir in parallel with the arterial pump. The reservoir has an inlet connected to the outlet of the pump and an outlet connected to the inlet of the pump. At least three blood flow paths can be configured. A main path has the inlet and outlet of the reservoir blocked while pumped blood flows through the venous cannula, the oxygenator, and the arterial cannula. An accumulator path has the inlet to the oxygenator and the outlet of the reservoir blocked while blood flows through the venous cannula and the inlet to the reservoir. A discharge path has the inlet of the reservoir blocked while the outlet is open whereby blood from the reservoir flows into the oxygenator. In a fourth configuration, the ECC fluid can be recovered in the reservoir and hemoconcentrated for autologous transfusion.
    Type: Application
    Filed: March 13, 2013
    Publication date: September 18, 2014
    Inventor: Keith SAMOLYK
  • Publication number: 20140272929
    Abstract: A method of causing an object to act as a cavitation nucleus comprising the steps of providing a sound energy source capable of generating a sound energy over a plurality of frequency ranges, providing a target object contained in a liquid, coupling the sound energy source to the liquid, determining a specific frequency range, within the frequency ranges, that resonates the target object, and exposing the target object to sound energy at the specific frequency range to cause the target object to act as a cavitation nucleus.
    Type: Application
    Filed: August 7, 2013
    Publication date: September 18, 2014
    Inventor: William L Puskas
  • Publication number: 20140272920
    Abstract: Described are systems and methods for monitoring administration of nitric oxide (NO) to ex vivo fluids. Examples of such fluids include blood in extracorporeal membrane oxygenation (ECMO) circuits or perfusion fluids used for preserving ex vivo organs prior to transplanting in a recipient. The systems and methods described herein provide for administering nitric oxide to the fluid, monitoring nitric oxide or a nitric oxide marker in the fluid, and adjusting the nitric oxide administration.
    Type: Application
    Filed: December 3, 2013
    Publication date: September 18, 2014
    Applicant: INO Therapeutics LLC
    Inventors: Jim Potenziano, Douglas R. Hansell, Jeff Griebel, Eddie Costa, Lisa Cooper
  • Patent number: 8834402
    Abstract: A method for the re-anticoagulation of platelet rich plasma in a blood apheresis system includes priming the blood apheresis system with anticoagulant, such that a volume of anticoagulant is transferred to a PRP container. The method may then transfer the anticoagulant within the PRP container to a red blood cell container, and collect a volume of platelet rich plasma within the PRP container. The platelet rich plasma may be collected in a plurality of cycles. Between collection cycles, the method may transfer a portion of the volume of anticoagulant from the red blood cell container to the PRP container.
    Type: Grant
    Filed: March 12, 2009
    Date of Patent: September 16, 2014
    Assignee: Haemonetics Corporation
    Inventors: Etienne Pagès, Michael Ragusa
  • Publication number: 20140255909
    Abstract: One aspect of the present disclosure relates to a bag for storing blood previously withdrawn from a subject. The bag can comprise a flexible, closed container and at least one removable heat transfer member adhered to an outer surface portion of the container. The container can include an inlet therein that forms part of the container. The inlet can be adapted for fluid-tight connection to a tube member through which the blood is caused to flow.
    Type: Application
    Filed: March 7, 2014
    Publication date: September 11, 2014
    Applicant: CyroMedic Technologies LLC
    Inventor: William Walter
  • Publication number: 20140255908
    Abstract: One aspect of the present disclosure relates to a bag for storing platelets or contaminated blood previously withdrawn from a subject. The bag can comprise a flexible, closed container and at least one removable heat transfer member adhered to an outer surface portion of the container. The container can include an inlet therein that forms part of the container. The inlet can be adapted for fluid-tight connection to a tube member through which the platelets or contaminated blood are caused to flow.
    Type: Application
    Filed: March 7, 2014
    Publication date: September 11, 2014
    Applicant: CryoMedic Technologies LLC
    Inventors: Willam Walter, Jimmy Walker
  • Publication number: 20140248600
    Abstract: A blood treatment apparatus adapted to preserve a blood treatment unit between blood treatment sessions. The blood treatment apparatus is configured to i) perform a blood treatment session and thereby use the blood treatment unit, ii) fill the blood treatment unit with a preservation fluid comprising at least one treatment fluid concentrate of a type that is used to prepare the treatment fluid, iii) maintain the preservation fluid in the blood treatment unit until a next blood treatment session is prepared, iv) dispatch the preservation fluid from the blood treatment unit in preparation of a next blood treatment session, and v) perform a next blood treatment session and thereby extend the use of the blood treatment unit. A related method is also described.
    Type: Application
    Filed: May 23, 2012
    Publication date: September 4, 2014
    Applicant: Gambro Lundia AB
    Inventors: Thomas Hertz, Mattias Holmer, Lennart Jonsson, Anders Wieslander, Helena Jeppsson