Oxygenator Patents (Class 422/45)
  • Patent number: 11090422
    Abstract: An extracorporeal heart-lung support machine apparatus includes a platform capable of supporting one or more pieces of equipment and at least one coupler mounted to the platform so as to provide a docking interface for a piece of equipment, wherein the coupler includes: an electrical interface configured to matingly engage with a complementary configured electrical interface of the at least one piece of equipment; and a locking mechanism configured to selectively transition between a locked configuration in which a latch member of the locking mechanism is positioned to secure the at least one piece of equipment to the coupler and an unlocked configuration in which the latch member of the locking mechanism is positioned to permit both engagement or disengagement of the electrical interface of the coupler with the electrical interface of the at least one piece of equipment.
    Type: Grant
    Filed: May 12, 2016
    Date of Patent: August 17, 2021
    Assignee: MAQUET CARDIOPULMONARY GMBH
    Inventors: Robert Hoff, Daniel A. Walters
  • Patent number: 11020715
    Abstract: The disclosure provides a gas-liquid dissolving apparatus, comprising: a sealed tank, a gas jet tube and a plurality of membrane plates; the sealed tank being provided with a liquid supply joint at top, and a gas inlet joint and an output joint at bottom; the gas jet tube being located inside the sealed tank and connected to the gas inlet joint; the gas jet tube having a plurality of gas jet holes distributed on tube wall; the plurality of membrane plates being stacked around the periphery of the gas jet tube and fixed; each membrane plate being ring-shaped, and being structured with an inner ring wall, a mixing chamber and an outer ring wall sequentially from the center; the mixing chamber having an opening facing downward, and the inner ring wall being thicker than the outer ring wall, with a gap existing between the two adjacent stacked outer ring walls.
    Type: Grant
    Filed: April 19, 2019
    Date of Patent: June 1, 2021
    Assignee: TRUSVAL TECHNOLOGY CO., LTD.
    Inventor: Shih-Pao Chien
  • Patent number: 10953150
    Abstract: A control system for controlling a quantity of blood in a blood reservoir (10) of a perfusion system supplied by a venous line (V), wherein a pump (20) circulates blood from the blood reservoir (10) through an outgoing line (A), comprises a venous flow sensor (22) to measure a venous blood flow rate, an outlet flow sensor (24) to measure an outgoing blood flow rate, and a controller to control the pump (20) to prevent the outgoing blood flow rate from exceeding the venous blood flow rate. Thereby, a decrease of blood in the blood reservoir (10) can be arrested.
    Type: Grant
    Filed: May 17, 2016
    Date of Patent: March 23, 2021
    Assignee: Spectrum Medical Ltd.
    Inventor: Stephen Turner
  • Patent number: 10780211
    Abstract: The present invention relates to an apparatus for carrying out an apheresis treatment, wherein the apparatus has an extracorporeal circuit in which a regenerable single adsorber is located for separating substances from blood or for separating substances from plasma acquired by means of a plasma separator, wherein a line is provided for conducting the blood or the plasma which extends to the adsorber and via which blood or plasma is applied to the adsorber, wherein a reservoir is provided for receiving blood or plasma and is arranged upstream of the adsorber in the line or is in communication with the line upstream of the adsorber; and in that a controller or switching means is provided which is configured such that the reservoir is filled with blood or plasma and the application of blood or plasma to the adsorber is suppressed when the regeneration of the adsorber is carried out.
    Type: Grant
    Filed: February 16, 2016
    Date of Patent: September 22, 2020
    Assignee: FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH
    Inventors: Hans-Peter Leinenbach, Frank Gebauer, Gerhard Mager, Juergen Klewinghaus
  • Patent number: 10682452
    Abstract: The invention relates to an apparatus for exchanging material between blood and a gas/gas mixture, comprising a chamber (1) through which blood can flow and in which a plurality of material-permeable fiber tubes is provided, the gas/gas mixture being flowable through the fiber tubes, blood being flowable around the fiber tubes. At least one deformable element (9) is provided in the chamber (1) in addition to the fiber tubes, through which the gas/gas mixture can flow, this deformable element being deformable and restorable, in particular compressible out of a relaxed shape and restorable to a relaxed shape by pressure fluctuations acting on the at least one element (9) externally, in particular pressure fluctuations transmitted by the blood in the chamber (1).
    Type: Grant
    Filed: January 7, 2016
    Date of Patent: June 16, 2020
    Assignee: ENMODES GMBH
    Inventors: Ralf Borchardt, Tim Kaufmann
  • Patent number: 10549022
    Abstract: An extracorporeal gas exchange device includes a housing, a rigid shaft rotatable within the housing, a plurality of agitation mechanisms positioned on the rigid shaft, and a plurality of hollow gas permeable fibers adapted to permit diffusion of gas between fluid flowing within the housing and an interior of the plurality of hollow gas permeable fibers. The plurality of hollow gas permeable fibers are positioned radially outward from the plurality of agitation mechanisms. The rotational speed of the rigid shaft is adjustable independent of the flow rate of fluid through the housing.
    Type: Grant
    Filed: January 20, 2016
    Date of Patent: February 4, 2020
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Richard Garrett Jeffries, William J. Federspiel, Brian Joseph Frankowski
  • Patent number: 10416104
    Abstract: The present invention relates to a gas sensing device comprising: a gas sensing part for outputting a gas detection result; and a correction control part for changing the value outputted from the gas sensing part to a reference value when the output value is lower than the reference value.
    Type: Grant
    Filed: July 7, 2015
    Date of Patent: September 17, 2019
    Assignee: LG INNOTEK CO., LTD.
    Inventor: Sung Gon Jun
  • Patent number: 10335530
    Abstract: An extracorporeal system for lung assist includes a system housing, which includes a blood flow inlet and a blood flow outlet and a fiber bundle housing movably positioned within the system housing. The fiber bundle housing includes a gas inlet and a gas outlet. A fiber bundle is in operative connection with the fiber bundle housing. The fiber bundle includes a plurality of hollow gas permeable fibers, wherein lumens of the plurality of hollow gas fibers are in fluid connection with the gas inlet at a first end thereof and in fluid connection with the gas outlet as a second end thereof. The system further includes an actuator to impart oscillatory motion to the fiber bundle housing and thereby to the fiber bundle.
    Type: Grant
    Filed: October 7, 2016
    Date of Patent: July 2, 2019
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Shalv Madhani, Brian Joseph Frankowski, William J. Federspiel
  • Patent number: 10117976
    Abstract: A medical device and method are disclosed which can facilitate maintenance work of a filter for capturing a capturing target, and which can improve operability or convenience in the maintenance work. The medical device has an accommodation unit, an impeller holding unit, and a filter. The accommodation unit accommodates a capturing target which is present inside a living body. The impeller holding unit includes an impeller which causes a fluid to flow from a distal side toward a proximal side inside the living body so as to cause the accommodation unit to aspirate the capturing target together with the fluid. Here, the impeller holding unit is configured to be attachable to and detachable from the accommodation unit on a proximal side of the accommodation unit. The filter is arranged in the accommodation unit and/or the impeller holding unit, and captures at last one or more of the capturing target.
    Type: Grant
    Filed: March 11, 2016
    Date of Patent: November 6, 2018
    Assignee: TERUMO KABUSHIKI KAISHA
    Inventor: Kei Honda
  • Patent number: 10088467
    Abstract: A blood testing apparatus includes a blood acquiring section that acquires a blood sample, a particle counter that measures a particle count in the blood sample, and an erythrocyte sedimentation rate (ESR) measuring section that measures a erythrocyte sedimentation rate in the blood sample. The particle counter and the ESR measuring section being arranged in parallel.
    Type: Grant
    Filed: March 10, 2015
    Date of Patent: October 2, 2018
    Assignee: NIHON KOHDEN CORPORATION
    Inventors: Hiroyuki Fukuda, Yoshihiro Niiyama, Fumihiko Murayama
  • Patent number: 9895518
    Abstract: The present invention provides methods and systems for conditioning cerebrospinal fluid (CSF) by removing target compounds from CSF. The systems provide for a multilumen flow path and exchange of a majority volume portion of CSF in the CSF space. The removal and/or delivery of specific compounds can be tailored to the pathology of the specific disease. The removal is targeted and specific, for example, through the use of specific size-exclusion thresholds, antibodies against specific toxins, and other chromatographic techniques, as well as delivery and/or removal of targeted therapeutic agents.
    Type: Grant
    Filed: March 13, 2013
    Date of Patent: February 20, 2018
    Assignee: NEUROFLUIDICS, INC.
    Inventors: Shivanand Lad, William C. Mobley, Karoly Nikolich, Thomas Saul
  • Patent number: 9655627
    Abstract: A device for use in preventing stroke is provided. The device may include an expandable member that expands from a non-expanded configuration to an expanded configuration. The expandable member is located at a neck of a patient. An associated method is provided.
    Type: Grant
    Filed: April 9, 2013
    Date of Patent: May 23, 2017
    Inventor: Michael Zhadkevich
  • Patent number: 9199023
    Abstract: An oxygenator includes a housing; a hollow fiber membrane layer that is stored in the housing and has multiple integrated hollow fiber membranes with a gas exchange function; a gas inlet portion and a gas outlet portion that are provided on the upstream and downstream of gas passages in lumens of the hollow fiber membranes, respectively; and a blood inlet portion and a blood outlet portion that are provided on the upstream and downstream of blood passages outsides of the hollow fiber membranes, respectively. The hollow fiber membranes in the hollow fiber membrane layer are fixed relative to each other at one end portion and the other end portion thereof. Conditions 30??60 and OD?4.5×? are met where ? [?m] is an average separation distance between the adjacent hollow fiber membranes at a fixed portion of the hollow fiber membrane layer and OD [?m] is the outer diameter of the hollow fiber membrane.
    Type: Grant
    Filed: September 30, 2013
    Date of Patent: December 1, 2015
    Inventor: Kazuhiko Takeuchi
  • Patent number: 9011769
    Abstract: A blood reservoir may be used in combination with other elements such as a heart lung machine (HLM), oxygenator, heat exchanger, arterial filter and the like to form an extracorporeal blood circuit that may be employed in a procedure such as a bypass procedure. The blood reservoir may be configured to receive, filter and store blood from a number of sources including vent blood (from within the heart), venous blood (from a major vein), purge blood (from a sampling line) and cardiotomy or suction blood (from the surgical field).
    Type: Grant
    Filed: July 13, 2011
    Date of Patent: April 21, 2015
    Assignee: Sorin Group Italia S.r.l.
    Inventors: Claudio Silvestri, Gabriele Tommasi
  • Patent number: 8980176
    Abstract: A blood processing apparatus may include a heat exchanger and a gas exchanger. The heat exchanger may be configured to provide a cross-flow or radially directed blood flow through the heat exchanger.
    Type: Grant
    Filed: May 18, 2011
    Date of Patent: March 17, 2015
    Assignee: Sorin Group Italia S.r.l.
    Inventors: Stefano Reggiani, Claudio Giovannini, Claudio Silvestri, Gabriele Tommasi
  • Patent number: 8968652
    Abstract: An oxygenator that inhibits or prevents bubbles in blood from exiting through a blood outlet includes an oxygenator part which performs gas exchange on blood and a heat exchanging part which performs heat exchange on the blood. The oxygenators part has a housing that is generally in a rectangular parallelepiped form, with a hollow fiber membrane bundle positioned in the housing. The hollow fiber membrane bundle is formed by a multiplicity of hollow fiber membranes adapted to perform gas exchange. Blood flows along a blood passage comprised of gaps between the hollow fiber membranes and contacts the surface of the hollow fiber membranes where gas exchange occurs with gas flowing through the lumens of the hollow fiber membranes. In addition, a filter member is arranged on a downstream side of the hollow fiber membrane bundle so that bubbles present in the blood are caught by the filter member.
    Type: Grant
    Filed: August 12, 2011
    Date of Patent: March 3, 2015
    Assignee: Terumo Kabushiki Kaisha
    Inventor: Mitsuaki Ogihara
  • Publication number: 20150057589
    Abstract: A method and apparatus for performing coronary perfusion and cardiac reoxygenation that enables accurate control of oxygen levels in blood used for the coronary circulation. Deoxygenated blood and oxygenated blood are collected and oxygen levels are measured by sensors. The deoxygenated and oxygenated blood is then mixed and the mixed blood is measured by another sensor. The sensors provide data used to provide real-time oxygen level measurement and adjustment for blood supplied for coronary circulation.
    Type: Application
    Filed: April 29, 2014
    Publication date: February 26, 2015
    Inventor: Neil J. Thomas
  • Publication number: 20150030502
    Abstract: An arrangement for extracorporeal life support is further developed in such a way that a pump actuating signal produces a wave-like surging and subsiding pump output for a pulsatile flow. The pump is preferably a non-occlusive blood pump, such as a diagonal pump, for example. In a preferred variant of embodiment the control signal is provided by an ECG. This allows the diastolic pressure to be increased in order to improve the oxygen balance of the heart muscle.
    Type: Application
    Filed: July 28, 2014
    Publication date: January 29, 2015
    Applicant: NOVALUNG GMBH
    Inventors: Holger GORHAN, Georg MATHEIS
  • Publication number: 20150024374
    Abstract: Blood or other fluids can be caused to interact with a gas by providing a plurality of fluid flow channels that are surrounded by nanotubes, each of the channels having an inflow end and an outflow end, wherein each of the channels is wide enough for the blood to flow through, and wherein the nanotubes are spaced close enough to each other to retain the fluid within the channels when the blood is flowing through the channels. The fluid is then passed through the through the channels while a gas is passed through the spaces between the nanotubes outside the fluid flow channels. This permits the gas to interact with the fluid in the channels.
    Type: Application
    Filed: July 15, 2014
    Publication date: January 22, 2015
    Inventor: Yoram Palti
  • Patent number: 8907554
    Abstract: An assembly of a support plate and an exit window foil for use in an electron beam generating device. The support plate is designed to reduce wrinkles in the foil. The foil is bonded to the support plate along a closed bonding line bounding an area in which the support plate is provided with a pattern of apertures and foil support portions alternately. When vacuum is created in the housing the pattern is adapted to form a topographical profile of the foil substantially absorbing any surplus foil. Another aspect involves a method in a filling machine for sterilizing a packaging material web.
    Type: Grant
    Filed: February 1, 2011
    Date of Patent: December 9, 2014
    Assignee: Tetra Laval Holdings & Finance S.A.
    Inventors: Ulrika Linné, Werner Haag, Toni Waber, Mattias Henriksson, Kurt Holm, Krister Kristiansson
  • Patent number: 8888737
    Abstract: A system and methods are described for improving the management of ischemic cardiac tissue during acute coronary syndromes or other ischemic conditions. A method and apparatus is described that allows mitigation of oxygen-related injury by precisely modulating the level of oxygen re-exposure during reoxygenation by a controlled feedback loop based on parameters of the tissue measured by a real-time tissue sensor or probe.
    Type: Grant
    Filed: October 20, 2009
    Date of Patent: November 18, 2014
    Assignee: Rheoxtech, LLC
    Inventors: Gintaras A. Vaisnys, Neil J. Thomas, James G. Moore
  • Patent number: 8865067
    Abstract: A combination oxygenator and arterial filter device for treating blood in an extracorporeal circuit includes a housing, an oxygenator, and a depth filter. The oxygenator includes a hollow fiber bundle forming an oxygenator exterior face. The depth filter is disposed (e.g., wound) directly over the exterior face, and includes a plurality of filaments arranged to define filter layers of level wound filaments. A first layer directly abuts the oxygenator exterior face. The oxygenator bundle differs from the depth filter in terms of: fiber and filament materials, construction of the fibers and filaments, and/or minimum gap spacings between axially adjacent ones of the fibers and the filaments. An oxygenator with integrated arterial filtering capability is provided that minimally impacts the extracorporeal blood circuit prime volume.
    Type: Grant
    Filed: April 29, 2011
    Date of Patent: October 21, 2014
    Assignee: Medtronic, Inc.
    Inventors: Robert Olson, John L. Knoll
  • Patent number: 8858880
    Abstract: Treatment of carbon monoxide poisoning of a body by removal of a portion of the blood from the body, placing the portion in an exposure cell, exposing the portion in the cell to light of wave length and intensity that causes dissociation of carbon monoxide from hemoglobin, and returning the portion to the body. The intensity and wave length of the light is sufficient to dissociate a therapeutically-effective amount of carbon monoxide from the hemoglobin in the blood. The blood is circulated from and to the body through a concentric double lumen cannula. The wave lengths of the light are 540 and/or 570 nanometers. The cell exposes the blood to at least 9.5 Joules of dissociative light per milliliter of blood, and least 9.5 Watts of dissociative light per milliliter of blood per second. Oxygen is provided to, and the dissociated carbon monoxide is removed from the system.
    Type: Grant
    Filed: February 13, 2012
    Date of Patent: October 14, 2014
    Inventor: Mark S. Smyczynski
  • Publication number: 20140271358
    Abstract: A system and associated tubing set for installation on the panel of extracorporeal circuit, including a pump tubing unit featuring a disposable pump. Two inlet line branches are fluidly connected to the pump inlet and two outlet line branches are fluidly connected to the pump outlet. The free ends of one inlet branch and one outlet branch carry a Colder type connector and a clamp between the pump and the respective Colder connectors. A blood reservoir unit has a support plate mountable to the panel, which carries a blood bag having an inlet line with a free end and Colder connector and an outlet line with free end and Colder connector.
    Type: Application
    Filed: March 13, 2013
    Publication date: September 18, 2014
    Inventor: Keith SAMOLYK
  • Publication number: 20140271357
    Abstract: In an extracorporeal blood circuit system or a machine configurable in such a circuit, a bag blood reservoir has an infusion port at the upper end of the bag, an outlet port at the lower end of the bag, an inlet port at the lower end of the bag, and an IV port at the lower end of the bag. A split line is connected to the infusion port, having a first branch line connected to a source makeup fluid into the reservoir and a second branch line that evacuates from the reservoir. An air detector and a vent controller automatically configure a venting path in which the inlet lines to the pump and to the blood reservoir are open such that air rises to the upper end of the blood reservoir from which it can be vented through the infusion port into the air evacuation line.
    Type: Application
    Filed: March 13, 2013
    Publication date: September 18, 2014
    Inventor: Keith SAMOLYK
  • Publication number: 20140234166
    Abstract: In one embodiment, an exsanguination preventing device includes a collection container having an inlet configured to receive blood from a patient and an outlet configured to discharge the blood; a pump operatively coupled to the collection container; a conduit fluidly coupled to the collection container, which receives the blood from the collection container, the blood being moved by the pump; and an insertion device, which delivers the blood from the conduit to a bodily part of the patient. The collection container is configured to be sealingly coupled to a wound on the patient and air entrapped within the exsanguination preventing device is removed by an air removal system, such to prevent unwanted discharge of air into the bodily part of the patient. All the components of the exsanguination preventing device are sized such to make it portable in a pocket of a garment or backpack of a soldier.
    Type: Application
    Filed: August 15, 2013
    Publication date: August 21, 2014
    Inventor: Dirk Jerome Erickson
  • Publication number: 20140219867
    Abstract: A blood treatment method is described that is adapted to at least partially eliminate the carbon dioxide content of the type comprising a step of drawing a blood flow. Advantageously according to the invention, the method further comprises the steps of: acidifying the blood flow with transformation of the related blood bicarbonate content into gaseous carbon dioxide; and eliminating the gaseous carbon dioxide content by means of a pressure gradient.
    Type: Application
    Filed: April 14, 2014
    Publication date: August 7, 2014
    Applicant: Universita degli Studi di Milano-Bicocca
    Inventors: Antonio Maria Pesenti, Nicolo Antonino Patroniti
  • Patent number: 8795591
    Abstract: An apparatus for oxygenating blood including a housing and an oxygenator bundle. The housing defines a primary chamber, a blood inlet port open to the primary chamber, and a blood outlet region. The outlet region includes a blood outlet port, an outlet chamber open to the outlet port, and a partition. The partition establishes spaced apart, first and second passageways from the primary chamber to the outlet chamber. The oxygenator bundle is disposed within the primary chamber. A blood flow path is formed from the blood inlet port, through the oxygenator bundle and to the blood outlet port, and includes first and second outlet flow paths within the outlet chamber via the first and second passageways, respectively. The first and second outlet blood flow paths merge at the blood outlet port. A dual port blood outlet is created, increasing mixing of blood immediately upstream of the outlet port.
    Type: Grant
    Filed: February 15, 2012
    Date of Patent: August 5, 2014
    Assignee: Medtronic, Inc.
    Inventors: Stephen Roller, Christopher Plott, Alford McLevish, Gregory Hake, Brian Steffens
  • Patent number: 8747742
    Abstract: A heat exchanger includes a case, a bottom member and a plurality of heat transfer pipes (a pipe group) loaded in the heat exchanger case, in which blood flows from one end through the bottom member. The bottom member has an annular wall, a bottom surface, and a blood inlet port. The bottom surface is opposed to one end of the heat transfer pipe. The bottom surface includes a groove portion and a raised bottom portion provided on each of opposing end sides of the groove portion. The raised bottom portion is inclined such that a distance between the raised bottom portion on a side where the blood inlet port is provided and one end of the heat transfer pipe is smaller than a distance between the raised bottom portion opposite to the side where the blood inlet port is provided and one end of the heat transfer pipe.
    Type: Grant
    Filed: February 15, 2011
    Date of Patent: June 10, 2014
    Assignee: Nipro Corporation
    Inventors: Shin-ichi Kawamura, Kazuhisa Ishihara, Naoaki Yasumura
  • Patent number: 8709343
    Abstract: A method and apparatus for performing coronary perfusion and cardiac reoxygenation that enables accurate control of oxygen levels in blood used for the coronary circulation. Deoxygenated blood and oxygenated blood are collected and oxygen levels are measured by sensors. The deoxygenated and oxygenated blood is then mixed and the mixed blood is measured by another sensor. The sensors provide data used to provide real-time oxygen level measurement and adjustment for blood supplied for coronary circulation.
    Type: Grant
    Filed: May 14, 2012
    Date of Patent: April 29, 2014
    Assignee: Rheoxtech, LLC
    Inventor: Neil J. Thomas
  • Publication number: 20140099235
    Abstract: An extracorporeal blood perfusion system includes a disposable assembly and a control unit having a control interface region. The interface region includes pump assemblies for selective pumping of venous blood, arterial blood, cardioplegia solution, suctioned blood and blood removed from the left ventricle. Valve assemblies control the flow of fluids through the assembly and to/from the patient and sensors monitor various fluid parameters including temperature and pressure within the various fluid circuits. The user interface is a functional screen interface for effecting the operation of the control unit and valve assemblies. The screen interface may be a touch screen having objects that corresponds to the component interface region. The display may be selectively controlled to provide graphic depictions of disposable assembly components with corresponding narrative instructions.
    Type: Application
    Filed: December 13, 2013
    Publication date: April 10, 2014
    Applicant: SORIN GROUP USA, INC.
    Inventors: Bruce S. Ellingboe, William D. Dalke, J. Steven Ingebrigtsen, John J. Kappus, Bruce E. Lawrence, Mike E. Schwab, Gary A. Carson, Kevin J. Kollar
  • Patent number: 8685319
    Abstract: A combination oxygenator and arterial filter device for treating blood in an extracorporeal blood circuit. The device includes a housing maintaining a core and a fiber bundle. The fiber bundle is formed by a plurality of hollow fibers continuously helically wound about the core to form layers of level wound fibers. The layers combine to define an oxygenator region and a radially outward depth filter region. A minimum gap spacing between fibers of the oxygenator region layers is greater than a minimum gap spacing of the depth filter region layers. The fiber bundle can function as a blood oxygenator and exhibits a filtration efficiency of not less than 92% in filtering particles having a particle size of about 45 microns. An oxygenator with integrated arterial filtering capability is provided that minimally impacts the extracorporeal blood circuit prime volume.
    Type: Grant
    Filed: April 29, 2011
    Date of Patent: April 1, 2014
    Assignee: Medtronic, Inc.
    Inventors: Robert Olson, John L. Knoll
  • Publication number: 20140079590
    Abstract: The disclosure pertains to a perfusion system that is easy to set-up, use and monitor during a bypass procedure. In some embodiments, the disclosure pertains to a perfusion system in which at least some of the disposable components used with the perfusion system are configured to be able to communicate set-up and/or operational parameters to the perfusion system in order to unlock further functionality within the perfusion system.
    Type: Application
    Filed: September 19, 2012
    Publication date: March 20, 2014
    Applicant: SORIN GROUP ITALIA, S.R.I.
    Inventors: Ivan Rossi, Raffaella Bombarda
  • Publication number: 20140050616
    Abstract: A monitoring system for cardiac operations with cardiopulmonary bypass comprising: a processor operatively connected to a heart-lung machine; a pump flow detecting device connected to a pump of the heart-lung machine to continuously measure the pump flow value and send it to the processor; a hematocrit reading device inserted inside the arterial or venous line of the heart-lung machine to continuously measure the blood hematocrit value and to send it to the processor; a data input device to allow the operator to manually input data regarding the arterial oxygen saturation and the arterial oxygen tension; computing means integrated in the processor to compute the oxygen delivery value on the basis of the measured pump flow, the measured hematocrit value, the preset value of arterial oxygen saturation, and the preset value of arterial oxygen tension; and a display connected to the processor to display in real-time the computed oxygen delivery value.
    Type: Application
    Filed: October 28, 2013
    Publication date: February 20, 2014
    Applicant: Sorin Group Italia S.r.l.
    Inventor: Marco Ranucci
  • Publication number: 20140050617
    Abstract: An apparatus for oxygenating blood including a housing and an oxygenator bundle. The housing defines a primary chamber, a blood inlet port open to the primary chamber, and a blood outlet region. The outlet region includes a blood outlet port, an outlet chamber open to the outlet port, and a partition. The partition establishes spaced apart, first and second passageways from the primary chamber to the outlet chamber. The oxygenator bundle is disposed within the primary chamber. A blood flow path is formed from the blood inlet port, through the oxygenator bundle and to the blood outlet port, and includes first and second outlet flow paths within the outlet chamber via the first and second passageways, respectively. The first and second outlet blood flow paths merge at the blood outlet port. A dual port blood outlet is created, increasing mixing of blood immediately upstream of the outlet port.
    Type: Application
    Filed: February 15, 2012
    Publication date: February 20, 2014
    Applicant: Medtronic, Inc.
    Inventors: Stephen Roller, Chistopher Plott, Alford McLevish, Gregory Hake, Brian Steffens
  • Patent number: 8647410
    Abstract: The invention provides systems and methods for exchanging gas in an oxygenator device, and methods for preparing and using such oxygenator devices. The systems and methods can be used to transfer oxygen to blood to assist lung function in a patient.
    Type: Grant
    Filed: May 26, 2011
    Date of Patent: February 11, 2014
    Assignee: The Charles Stark Draper Laboratory, Inc.
    Inventors: Jeffrey T. Borenstein, Joseph L. Charest, James Ching-Ming Hsiao, Tatiana Kniazeva
  • Patent number: 8647569
    Abstract: A paracorporeal respiratory assist lung is configured with an annular cylindrical hollow fiber membrane (fiber bundle) that is rotated at rapidly varying speeds. Fluid (for example, blood) is introduced to the center of the device and is passed radially through the fiber bundle. The bundle is rotated at rapidly changing velocities with a rotational actuator (for example, a motor or magnetic coupling). The rotation of the fiber bundle provides centrifugal kinetic energy to the fluid giving the device pumping capabilities and may create Taylor vortexes to increase mass transfer. Rotation of the fiber bundle increases the relative velocity between the fluid and the hollow fibers and increases the mass transfer. The porosity of the fiber bundle may be varied to enhance gas exchange with the blood. Alternatively, a rotating core may be used with a stationary fiber bundle.
    Type: Grant
    Filed: April 11, 2011
    Date of Patent: February 11, 2014
    Assignee: ALung Technologies, Inc
    Inventors: William J. Federspiel, Brian J. Frankowski, Brendan C. Mack, Scott W. Morley, Meir Rosenberg, Robert G. Svitek
  • Patent number: 8636952
    Abstract: This invention discloses a modular system having a base module, a mid-section control module, and a display module for preparing and administering a gas-enriched bodily fluid via an extracorporeal circuit. Gas-enrichment is achieved by a gas-enriching device which can be in the form of a disposable cartridge. The gas-enrichment device has an information recording element disposed thereon. During operation, the gas-enrichment device is placed in an enclosure within the control module. An electronic controller manages the various aspects of the system such as the production of gas-enriched fluid, flow rates, bubble detection, and automatic operation and shut down. The controller is capable of setting a fluid flow rate in the circuit according to a programming based on the information encoded in the information recording element.
    Type: Grant
    Filed: December 4, 2008
    Date of Patent: January 28, 2014
    Assignee: TherOx, Inc.
    Inventors: Stephen E. Myrick, Gregory P. Watson, Jeffrey L. Creech, John M. Aoki
  • Publication number: 20130345614
    Abstract: The invention provides a device for extracorporeal photo-isomerization of bodily fluid containing bilirubin. The bodily fluid derives from a patient suffering from an elevation of unconjugated bilirubin. The device includes a sterile tubing which accesses the patient's bodily fluids (especially blood), routes the fluid into an extracorporeal chamber within which irradiation of bodily fluids takes place, and returns bodily fluids to the patient. Bodily fluids are continuously circulated through a single length of sterile tubing using an adjustable pump to regulate the flow, and as the fluid passes into the extracorporeal chamber it is irradiated by blue light within the chamber with an emission wavelength range of approximately 450 to 530 nm. This irradiation induces a photochemical reaction in bilirubin that changes its structure and facilitates improved excretion of bilirubin once it is returned to the patient. The extracorporeal photo-isomerization turns the bilirubin into a more readily excreted form.
    Type: Application
    Filed: June 24, 2013
    Publication date: December 26, 2013
    Inventor: Viraj P. Mane
  • Patent number: 8591449
    Abstract: A device for storing and dispensing a fluid and fluid energy using continuous analog modification of the total surface area of one or more solid surfaces against which, on one side of such surface(s), the fluid to be stored and dispensed may proximally and forcibly act and against which, on the opposed side of such surface(s), one or more elastic elements may act, withal producing the effect of a substantially constant static pressure across a range of deformation of the elastic element(s), i.e., a piezoequilibrative effect.
    Type: Grant
    Filed: October 18, 2010
    Date of Patent: November 26, 2013
    Inventor: Dennis Sheanne Hudson
  • Patent number: 8585968
    Abstract: A method and system for improving gas exchange properties of oxygenators which utilize hollow fiber membranes for removing carbon dioxide or adding oxygen to a patient's blood via extracorporeal circulation by removing moisture accumulating in the fibers are disclosed. The system utilizes a vacuum source for drawing sweep gas into the oxygenator, a moisture collection unit for storing moisture removed from the oxygenator, the moisture collecting unit being in communication with the oxygenator and the vacuum source and a flow control mechanism having an open position which allows sweep gas exiting the oxygenator to flow to the moisture collecting unit and a closed position which stops the flow of sweep gas from the oxygenator to the moisture collecting unit.
    Type: Grant
    Filed: October 29, 2009
    Date of Patent: November 19, 2013
    Inventors: Scott W. Morley, Paul Bieniek, Meir Rosenberg
  • Patent number: 8585969
    Abstract: A device for treating blood in an extracorporeal blood circuit, the device including a centrifugal pump provided with a transparent enclosure that is connected, by means of an inlet duct, to the outlet of a venous reservoir, the venous reservoir having an inlet that is connected to receive blood from a patient. The transparent enclosure of the pump is connected monolithically to the base of a structure that comprises a heat exchanger and an oxygenator. The structure also supports monolithically, at the peripheral region, an arterial filter that receives the blood in output from the oxygenator and is provided with a connector for coupling to an arterial line for return of the blood to the patient.
    Type: Grant
    Filed: January 31, 2011
    Date of Patent: November 19, 2013
    Assignee: Sorin Group Italia S.r.l.
    Inventors: Edgardo Costa Maianti, Nicola Ghelli, Ivo Panzani
  • Patent number: 8551770
    Abstract: Provided is a cell culture apparatus for culturing cells, that provides enhanced oxygen delivery and supply to cells without the need for stirring or sparging. Oxygen diffusion occurs on both sides of the culture vessel, top and bottom. A gas-permeable membrane that includes perfluorocarbons in its composition allows for the rapid, enhanced and uniform transfer of oxygen between the environment of cells or tissues contained in the cell culture container apparatus and the atmosphere of the incubator in which the cell culture apparatus is incubated.
    Type: Grant
    Filed: July 9, 2007
    Date of Patent: October 8, 2013
    Assignee: University of Miami
    Inventors: Christopher A. Fraker, Juan Dominguez-Bendala, Ricordi Camillo, Luca Inverardi
  • Patent number: 8545754
    Abstract: Disclosed is an apparatus for oxygenating and controlling the temperature of blood in an extracorporeal circuit. The apparatus has an inlet and an outlet that is located radially outward from the inlet in order to define a flowpath through the apparatus. The apparatus comprises: a core that is substantially centrally located in the apparatus and to which blood from a patient can be supplied through the inlet; a heat exchanger comprising a plurality of heat transfer elements that are arranged around the core and between which blood from the core can move radially outward; and an oxygenator comprising a plurality of gas exchange elements that are arranged around the heat exchanger and between which blood from the heat exchanger can move radially outward before exiting the apparatus through the outlet.
    Type: Grant
    Filed: April 23, 2009
    Date of Patent: October 1, 2013
    Assignee: Medtronic, Inc.
    Inventors: Walt L. Carpenter, Robert W. Olsen, Michael J. Hobday, Alford L. McLevish, Christopher J. Plott, Roderick E. Briscoe, Patrick J. Cloutier, Anil Thapa, Ming Li, Kevin McIntosh, Ken Merte
  • Patent number: 8529834
    Abstract: There is provided a mass exchange apparatus (114) for use in blood/air mass exchange comprising plural blood flow conduits for defining a blood flow from a blood flow inlet provided thereto; and plural air flow conduits for defining an air flow from an air flow inlet provided thereto. The plural air flow conduits and plural blood flow conduits at least partially comprise gas-permeable membrane material, and the conduits are arranged relative to each other such as to enable transfer of oxygen from the air flow to the blood flow and transfer of carbon dioxide from the blood flow to the air flow through the membrane material.
    Type: Grant
    Filed: October 10, 2008
    Date of Patent: September 10, 2013
    Assignee: Haemair Ltd.
    Inventor: Richard William Johns
  • Patent number: 8518259
    Abstract: An apparatus for de-aering, oxygenating and controlling a temperature of blood in an extracorporeal blood circuit. The apparatus includes a housing, a manifold body, a heat exchanger, and an oxygenator. A blood inlet tangentially directs blood into a first chamber of the housing. The manifold body is disposed in a second chamber, and includes a core and a plurality of vanes that define channels. The heat exchanger is arranged around the manifold body, and the oxygenator around the heat exchanger. The channels are open to the heat exchanger. An established blood flow path includes rotational flow within the first chamber to separate air from the blood, generally longitudinal flow from the first chamber and along the channels, and generally radial flow through the heat exchanger and the oxygenator. With this construction, gross air removal occurs prior to the blood passing through the heat exchanger and oxygenator.
    Type: Grant
    Filed: January 27, 2011
    Date of Patent: August 27, 2013
    Assignee: Medtronic, Inc.
    Inventors: Patrick Cloutier, Robert Olsen, Stephen Roller, Chris Plott, Al McLevish, Ming Li, Michael Laxen, John Knoll, Gregory Hake
  • Patent number: 8517969
    Abstract: A liquid collection bag is used as a part of an extracorporeal circuit and is connected via a tube to a storage container containing a priming solution. The collection container collects the priming solution from the storage container by a pressure differential between the pressure inside the collection container and the pressure inside the storage container. The liquid collection container is a flexible bag body having a partition part dividing the inside of the bag body into a first space and a second space. In addition, a communication part communicates the first space with the second space.
    Type: Grant
    Filed: November 16, 2012
    Date of Patent: August 27, 2013
    Assignee: Terumo Kabushiki Kaisha
    Inventors: Norikazu Ishida, Hidetaka Nakayama
  • Patent number: 8518326
    Abstract: A method may include obtaining information representing at least one of a concentration of carbon dioxide in a patient's blood, a concentration of oxygen in the patient's blood or a pH value of the patient's blood. The method may also include setting an initial carbon dioxide tension in a membrane oxygenator of an extra-corporeal membrane oxygenation (ECMO) system based on the obtained information.
    Type: Grant
    Filed: November 26, 2010
    Date of Patent: August 27, 2013
    Inventors: Ken M. Brady, Robert A. Baruch
  • Publication number: 20130209314
    Abstract: An apparatus for oxygenating blood including a housing and an oxygenator bundle. The housing defines a primary chamber, a blood inlet port open to the primary chamber, and a blood outlet region. The outlet region includes a blood outlet port, an outlet chamber open to the outlet port, and a partition. The partition establishes spaced apart, first and second passageways from the primary chamber to the outlet chamber. The oxygenator bundle is disposed within the primary chamber. A blood flow path is formed from the blood inlet port, through the oxygenator bundle and to the blood outlet port, and includes first and second outlet flow paths within the outlet chamber via the first and second passageways, respectively. The first and second outlet blood flow paths merge at the blood outlet port. A dual port blood outlet is created, increasing mixing of blood immediately upstream of the outlet port.
    Type: Application
    Filed: February 15, 2012
    Publication date: August 15, 2013
    Applicant: Medtronic, Inc.
    Inventors: Stephen Roller, Chistopher Plott, Alford McLevish, Gregory Hake, Brian Steffens
  • Patent number: 8496874
    Abstract: An integrated centrifugal blood pump-oxygenator (1) which has a housing (2) with a top (3) having a blood inlet (4), a blood outlet (5) and a gas inlet (6), and a bottom (7) having a rotational body (8) being rotatably arranged in a rotor-housing (9) of the bottom (7). The integrated centrifugal blood pump-oxygenator (1) further has an oxygenator membrane (10) provided in an interior (11) of the housing (2), wherein in the operation state oxygen (12) is transferred from the gas inlet (6) through the oxygenator membrane (10) to a gas outlet (13) and blood (14) is brought in direct contact with the oxygenator membrane (10) by pumping the blood (14) with the rotational body (8) from the blood inlet (4) to the blood outlet (5). The rotational body (8) is magnetically journalled in a contact-free manner with respect to the rotor-housing (9). There is an extracorporeal life support system (1000), and a method of de-bubbling and priming a extracorporeal life support system (1000).
    Type: Grant
    Filed: December 5, 2007
    Date of Patent: July 30, 2013
    Assignee: Thoratec LLC
    Inventors: Barry N. Gellman, Andrew Koert, Zhongjun Wu, Juntao Zhang, Bartley P. Griffith