Including Seal Penetration Means Patents (Class 422/512)
  • Patent number: 11011807
    Abstract: A coupling frame includes a support body configured to contact at least one of the electrode tab and the electrode lead; a first perforating portion bent from one end of the support body; and a second perforating portion bent from the other end of the support body. The first and second perforating portions are inserted into the electrode tab and the electrode lead to pass through first and second points of a contact surface between the electrode tab and the electrode lead.
    Type: Grant
    Filed: February 2, 2018
    Date of Patent: May 18, 2021
    Inventors: Seung-Hee Ko, Jae-Bin Chung
  • Patent number: 10788478
    Abstract: An object is to perform analysis of a target component contained in a small volume of blood sample at high accuracy using a normal component homeostatically present in blood. Provided is a blood test kit for analyzing a concentration of a target component in a blood sample by using a normal component homeostatically present in blood, the kit including: a diluent solution for diluting a blood sample; and a member selected from the group consisting of a first storing instrument in which the diluent solution is stored, a separating instrument for separating and recovering blood plasma from the blood sample diluted with the diluent solution, a holding instrument for holding the separating instrument, a second storing instrument for storing the recovered blood plasma, and a sealing instrument for keeping the stored blood plasma in the second storing instrument, in which an amount of the normal component which is derived from the member and may be contained in the diluent solution is defined.
    Type: Grant
    Filed: January 4, 2018
    Date of Patent: September 29, 2020
    Assignee: FUJIFILM Corporation
    Inventors: Hikaru Urano, Haruyasu Nakatsugawa, Susumu Osawa, Shinya Sugimoto
  • Patent number: 10634661
    Abstract: An object of the present invention is to provide a blood analysis method in which a high level of repeatability and reproducibility is achieved with respect to measurement values in a blood sample of 50 ?L or less, and a blood test kit which is used for the blood analysis method. According to the present invention, a blood analysis method including a step of diluting a collected blood sample with a diluent solution; a step of determining a dilution factor by using a normal value of a normal component which is homeostatically present in the blood; and a step of analyzing a concentration of a target component in the blood sample, in which a volume of the blood sample is 50 ?L or less, a dilution factor of blood plasma components in the blood sample is 14 or higher, and the diluent solution is a diluent solution which does not contain the normal component which is homeostatically present in the blood, is provided.
    Type: Grant
    Filed: January 3, 2018
    Date of Patent: April 28, 2020
    Assignee: FUJIFILM Corporation
    Inventors: Tatsuya Ishizaka, Haruyasu Nakatsugawa, Susumu Osawa, Shinya Sugimoto
  • Patent number: 9028756
    Abstract: A specimen analyzing method and a specimen analyzing apparatus capable of measuring interference substances before analyzing a specimen. The method comprises a step for sucking the specimen stored in a specimen container (150) and sampling it in a first container (153), a step for optically measuring the specimen in the first container, a step for sampling the specimen in a second container (154) and preparing a specimen for measurement by mixing the specimen with a reagent in the second container, and a step for analyzing the specimen for measurement according to the results of the optical measurement of the specimen.
    Type: Grant
    Filed: August 30, 2013
    Date of Patent: May 12, 2015
    Assignee: Sysmex Corporation
    Inventors: Norimasa Yamamoto, Takashi Yamato, Naohiko Matsuo, Satoshi Iguchi
  • Publication number: 20150125364
    Abstract: A reagent preparation assembly includes a body and a reaction chamber adjacent the body, the reaction chamber includes a reagent therein, such as a lyophilized reagent. An access port extends into the reaction chamber, and the access port is configured to receive an instrument. A seal extends across a portion of the reaction chamber and the access port. A reconstitution assembly is movably coupled with the body. The reconstitution assembly includes a plunger, a syringe and a piston. The plunger is movably coupled with the body. The syringe is selectively engaged with the plunger. The syringe includes a solution reservoir containing a solution, and movement of the syringe pierces the seal. The piston is selectively engaged with the plunger, and the piston is movably coupled within the syringe. Movement of the piston pushes the solution into the reaction chamber.
    Type: Application
    Filed: January 15, 2015
    Publication date: May 7, 2015
    Inventors: Timothy Pearcy, James G. Skakoon
  • Patent number: 9012236
    Abstract: The invention provides a system that can process a raw biological sample, perform a biochemical reaction and provide an analysis readout. For example, the system can extract DNA from a swab, amplify STR loci from the DNA, and analyze the amplified loci and STR markers in the sample. The system integrates these functions by using microfluidic components to connect what can be macrofluidic functions. In one embodiment the system includes a sample purification module, a reaction module, a post-reaction clean-up module, a capillary electrophoresis module and a computer. In certain embodiments, the system includes a disposable cartridge for performing analyte capture. The cartridge can comprise a fluidic manifold having macrofluidic chambers mated with microfluidic chips that route the liquids between chambers. The system fits within an enclosure of no more than 10 ft3. and can be a closed, portable, and/or a battery operated system. The system can be used to go from raw sample to analysis in less than 4 hours.
    Type: Grant
    Filed: August 15, 2013
    Date of Patent: April 21, 2015
    Assignee: IntegenX Inc.
    Inventors: Stevan B. Jovanovich, William D. Nielsen, David S. Cohen, Michael Recknor, Mattias Vangbo, Ezra Van Gelder, Omar El-Sissi
  • Patent number: 8997800
    Abstract: A system (10) for removing a pipettable substance from a pre-filled container (20), which is closed off by a top (30) having at least one opening area (40), comprises an opening tool (100) having a tube (110), which has a cross-section corresponding substantially to the shape of the opening area and which comprises at a distal end (120) an endpiece (140) extending substantially obliquely relative to the longitudinal axis of the tube, which moves a part of the top (30) located inside the opening area (40) towards the container when the opening tool is applied, so as to form an opening in the top, and a point of attack (150) for a transporting tool (200). The opening tool (100) is designed to remain on the container (20) after use.
    Type: Grant
    Filed: August 18, 2008
    Date of Patent: April 7, 2015
    Assignee: Qiagen GmbH
    Inventors: Thomas Voit, Andrea Wildhaber
  • Patent number: 8992833
    Abstract: The present invention provides a system and method for the simultaneous detection of multiple analytes in a sample. The detection system includes a housing that holds a reagent carousel rotatably coupled thereto. Further included in the housing is an incubator carousel rotatably coupled thereto. The housing also includes magnetic material that is associated with the incubation carousel for assisting in separation beads from reagent and wash solution. A robot, associated with the housing is configured to manipulate at least either the reagent carousel or the incubator carousel and transfer materials therebetween. Reaction vessels hold samples and reaction vessels handlers move the reaction vessels. Sample analysis is determined by at least one laser based detector.
    Type: Grant
    Filed: December 17, 2012
    Date of Patent: March 31, 2015
    Assignee: Bio Rad-Laboratories, Inc.
    Inventors: Lawrence Blecka, Larry Seamer, Sachi Rastogi, Chris Tsai, Nasser Jafari, Ken J. Lafredo
  • Patent number: 8986611
    Abstract: A sample analysis apparatus configured to automatically press a start button upon installation of a sample tube is provided. The sample analysis apparatus includes: a body of the sample analysis apparatus; a door housing which may be provided in an opened state or a closed state, and configured to be coupled to the body of the sample analysis apparatus by a hinge; a tube accommodating unit included in the door housing and configured to accommodate the sample tube; a start button included in the body of the sample analysis apparatus and configured to start analysis of the sample; and an operating member positioned at a first position which is distant from the start button the sample tube is not installed in the tube accommodating unit, and a second position which is configured to operate the start button when a sample tube is installed and the door housing is closed.
    Type: Grant
    Filed: August 2, 2012
    Date of Patent: March 24, 2015
    Assignee: Samsung Electronics Co., Ltd.
    Inventors: Yong Koo Lee, Tae Soo Kim, In Duk Hwang, Seock Woo Jang, Chul Ho Yun
  • Patent number: 8974750
    Abstract: A nozzle device which can perform accurate quantitative suction without being affected by a pressure when, for example, a nozzle (2) is inserted into a closed container (T). The nozzle device has the nozzle (2) that is inserted into the closed container (T) and that sucks a liquid in the closed container (T), an exposure to atmosphere mechanism (3) that opens the closed container (T) to the atmospheric air, and an opening/closing structure (4) that is arranged at a proximal end of the nozzle (2) and that has an internal flow channel (411) communicated with a flow channel in the nozzle (2) and an opening/closing mechanism for opening and closing the internal flow channel (411), and an opening/closing control section (5) that controls the opening/closing mechanism.
    Type: Grant
    Filed: December 18, 2008
    Date of Patent: March 10, 2015
    Assignee: Horiba, Ltd.
    Inventors: Soichi Oue, Yoshihiro Yano, Narihiro Oku
  • Patent number: 8940251
    Abstract: A sample liquid supply device includes a container tip into which the sample liquid is introduced, a hollow needle provided at one end of the container tip such that a hollow part thereof communicates with inside of the container tip, and a sealing member that covers an opening from which the sample liquid is introduced, wherein the sealing member has a puncture-sealing property achieved by elastic deformation.
    Type: Grant
    Filed: January 13, 2012
    Date of Patent: January 27, 2015
    Assignee: Sony Corporation
    Inventor: Hidetoshi Watanabe
  • Publication number: 20140341787
    Abstract: A mechanically-actuated vacuum-controlled fluid collection system includes a mechanically-actuated vacuum controller (MAVC) to draw fluid into a chamber through the opening to the chamber. The system may include a releasable seal to seal the opening, and the MAVC may include a spring-loaded plunger to create a vacuum within the chamber when sealed. The system includes multiple fluid chambers, and may further include a single actuator or multiple corresponding actuators. The system may be configured to add a pre-loadable reagent to fluid drawn into the one or more chambers, and may be configured to add the reagent in proportion to a volume of the fluid. The system may be controllable to release collected fluid to another device, such as for assay and/or transport. The system may be configured to draw a liquid biological sample such as urine, and may include a fluid interface to draw fluid from a biological sample container.
    Type: Application
    Filed: December 5, 2013
    Publication date: November 20, 2014
    Applicant: Boston Microfluidics
    Inventors: Brandon T. JOHNSON, Kate E. CHRISTIAN, Glenn H. VERNER
  • Publication number: 20140248704
    Abstract: A method which allows easy perforation of a film covering a well of a reagent cartridge which is set to a dispensing device is provided. A pipette tip set to be used in a dispensing device of an automatic analyzer together with a reagent cartridge in which a reagent for biochemical analysis is enclosed, includes: a dispensing pipette tip for dispensing the reagent enclosed in the reagent cartridge; a perforating pipette tip having a leading end surface inclined relative to a central axis thereof; and a rack configured to store the dispensing pipette tip and the perforating pipette tip together.
    Type: Application
    Filed: May 16, 2014
    Publication date: September 4, 2014
    Applicant: TOPPAN PRINTING CO., LTD.
    Inventors: Tatsuya UEKI, Hiroyuki Kuroki, Eiji Kawata
  • Patent number: 8821705
    Abstract: A digital microfluidics system manipulates samples in liquid droplets within disposable cartridges and has disposable cartridges each with a bottom layer, a top layer and a gap therebetween. A base unit with cartridge accommodation sites and at least one electrode array with electrodes works with a cover plate at the sites and a control unit for controlling selection of the electrodes and for providing them with voltage pulses for manipulating liquid droplets within the cartridges by electrowetting. The cover plate has an electrically conductive material that extends parallel to the array. A selection of disposable cartridges and a method for manipulating samples in liquid droplets that adhere to a hydrophobic surface can be used with the system.
    Type: Grant
    Filed: November 25, 2011
    Date of Patent: September 2, 2014
    Assignee: Tecan Trading AG
    Inventors: Torleif Ove Bjornson, Marc Nathan Feiglin, Michael Benjamin Franklin, Anne R. Kopf-Sill, Travis Lee, Kailiang Wang
  • Publication number: 20140220702
    Abstract: Fluid storage containers and analysis cartridges for use in assay processes are presented. In addition, systems comprising such storage containers and analysis cartridges and methods of using such containers and cartridges are presented as well. In specific embodiments, fluid storage containers are configured to be coupled to analysis cartridges in a first stage and a second stage.
    Type: Application
    Filed: January 31, 2014
    Publication date: August 7, 2014
    Applicant: LUMINEX CORPORATION
    Inventors: Ross JOHNSON, Chuck Collins
  • Patent number: 8771615
    Abstract: A compound container has a container main body forming a first accommodation chamber, an auxiliary container forming a second accommodation chamber, a mounting part on which the auxiliary container is mounted in the container main body, a cutting part which cuts a second accommodation chamber partition wall which partitions a part of the second accommodation chamber formed in the auxiliary container, a contents outlet port in the container main body, and an opening pouring element mounted on the contents outlet port and having another cutting part which cuts a first accommodation chamber partition wall which partitions a part of the first accommodation chamber formed in the container main body.
    Type: Grant
    Filed: March 3, 2009
    Date of Patent: July 8, 2014
    Assignees: Toyo Seikan Kaisha, Ltd., Eiken Kagaku Kabushiki Kaisha
    Inventors: Tomoyuki Shibata, Natsuki Masuya, Yoshiaki Seto, Shingo Saito, Yasuyoshi Mori, Yutaka Kubota, Hidetoshi Kanda, Tsugunori Notomi, Teijirou Kanada, Youichi Takano, Yasuyuki Takeuchi, Akira Onishi
  • Patent number: 8758702
    Abstract: A clinical diagnostic sample analyzer for analyzing a sample of a patient is disclosed. The analyzer includes a telescoping closed-tube sampling assembly with a sample probe concentrically housed within a piercing probe and a venting mechanism. The closed-tube sampling assembly is used for aspirating a sample from a sample tube for analysis by a clinical diagnostic sample analyzer.
    Type: Grant
    Filed: May 4, 2006
    Date of Patent: June 24, 2014
    Assignee: Instrumentation Laboratory Company
    Inventors: Matthew Blouin, Gregory Murphy, Diana Mackenzie, Alan Weeks, Daniel Kobrenski
  • Patent number: 8758708
    Abstract: It comprises, in addition to a sampling system (3), at the outlet of a vat (1) containing the liquid to be sampled, a selector (4) that establishes switching on an array of similar vats (1), and especially a suction unit (5) that operates by releasing compressed air into a nozzle (28); the airflow direction is controlled by a valve (29) between a direction directed toward the outlet (6), causing the suction of the liquid from the vat (1), and an opposite direction when the valve (29) is closed, feeding the liquid back into the vat (1) and cleaning the pipe (2).
    Type: Grant
    Filed: September 24, 2010
    Date of Patent: June 24, 2014
    Assignee: Commissariat a l'Energie Atomique et aux Enegies Alternatives
    Inventors: Christophe Brenneis, Hervé Lagrave, Jacques Mamert
  • Patent number: 8715593
    Abstract: The present invention is a pipette tip device for extraction of liquid, semi-solid or solid solutions to be chemically analyzed and the methods for their use. The pipette tip extraction device contains a screen or filter at its lower narrow end to contain solid particulate matter and a barrier at its upper wide end. The optional upper frit is to be made of material that permits liquid solutions to flow through it. In addition to the barrier and screen, the pipette tip extraction device may contain solid-phase sorbent. Through the use of a removable cap, the pipette extraction tip may also serve as a sample collection container or tip in which samples can be delivered to the top of the tip (e.g., for direct collection of samples, including solid samples). A new method for DPX extraction using liquid-liquid-solid-phase extraction is also disclosed.
    Type: Grant
    Filed: February 21, 2008
    Date of Patent: May 6, 2014
    Inventor: William Brewer
  • Patent number: 8685347
    Abstract: A cap having a core structure dimensioned to receive a pipette therethrough. The cap includes two axially aligned frangible seals that are affixed to the core structure in a spaced-apart relationship. The frangible seals include a foil layer and are constructed so that air passageways are formed between the frangible seals and a pipette tip when the pipette tip penetrates the frangible seals. The cap optionally includes a filter interposed between the first and second frangible seals.
    Type: Grant
    Filed: November 15, 2011
    Date of Patent: April 1, 2014
    Assignee: Gen-Probe Incorporated
    Inventors: Daniel L. Kacian, Mark R. Kennedy, Nick M. Carter
  • Publication number: 20140083565
    Abstract: The invention relates to a hollow needle (1) for a sample pipettor in an automated analysis instrument, which sample pipettor is suitable for withdrawing sample liquid from a sealed sample vessel by virtue of the cover or the cap of the sample vessel being pierced by the hollow needle (1). The hollow needle (1) has a substantially straight cylindrical basic shape with a tip (8) for piercing a cover and enables a removal of sample liquid, comparatively less susceptible to errors, from a sample vessel in an automated analysis instrument. In the region of the tip (8) of the hollow needle (1), a number of faces (22, 26, 28, 30) have been introduced in such a way that the radial force components resulting at the respective faces (22, 26, 28, 30) during an axial movement into an elastic material cancel one another.
    Type: Application
    Filed: September 19, 2013
    Publication date: March 27, 2014
    Applicant: Siemens Healthcare Diagnostics Products GmbH
    Inventors: Rudolf Kressirer, Eike Ziechner
  • Patent number: 8633032
    Abstract: A nucleic acid extraction kit, which enables the nucleic acid extraction operation to be accomplished safely without causing contamination, and in which the complex preparation of reagents and the disposal treatments that are performed before and after the nucleic acid extraction operation can be performed rapidly and simply, with the extraction performed in an automated manner. The nucleic acid extraction kit includes: a container including reagent wells that each store at least a reagent, a sample well into which a biological sample is introduced, a waste liquid well, and a collection well in which an extracted nucleic acid is collected, and an extraction filter cartridge equipped with an extraction filter for separating and extracting a nucleic acid from the biological sample, wherein the extraction filter cartridge is formed in a manner that enables the extraction filter cartridge to be supported on the waste liquid well and the collection well.
    Type: Grant
    Filed: February 19, 2013
    Date of Patent: January 21, 2014
    Assignee: Toppan Printing Co., Ltd.
    Inventors: Shuichi Akashi, Ryoichi Asai
  • Patent number: 8623298
    Abstract: A syringe comprises a syringe body (12) having an axial inner recess (14) extending in the direction of a longitudinal axis of the syringe body (L), a piston (16) being guided in an axially moveable manner in said inner recess and contributing to the delimitation of a fluid-receiving volume together with a section of a wall (14a) radially delimiting the inner recess (14), and having a needle (24) that can be or is connected to a longitudinal end (12a) of the syringe body (12), wherein the needle (24) has a coupling geometry (28) at the longitudinal end (24a) thereof that is closer to the syringe body, wherein the needle (24) can be connected by said coupling geometry to a counter coupling geometry (30) of the syringe body (12), wherein the geometry composed of the coupling geometry (28) and counter coupling geometry (30) comprises an insertion section (32), which in the assembled state of the syringe (10) is received in a coupling recess (34) of the respectively other geometry, and wherein furthermore safety
    Type: Grant
    Filed: September 19, 2008
    Date of Patent: January 7, 2014
    Assignee: Hamilton Bonaduz AG
    Inventor: Klaus Leckebusch
  • Patent number: 8623297
    Abstract: The present invention relates to a device, to a system, and to a method for the preparation and fractioned dispensing of samples of a fluid. The device of the invention comprises a body having formed therein guide means suitable for receiving a sample-taker member and for guiding it in translation through the device, and at least one preparation chamber enabling an aliquot of a fluid sample dispensed into the chamber by a said sample-taker member to be prepared in a stream of a suitable reagent. The guide means pass through the preparation chamber and communicate therewith to enable an aliquot of fluid to be dispensed into the chamber in a determined position of the sample-taker member in the guide means. The preparation chamber has an introduction orifice for introducing at least one reagent into the chamber for mixing the reagent with an aliquot, and at least one dispensing orifice for dispensing the mixture formed by said aliquot and said reagent to recovery and/or analysis means.
    Type: Grant
    Filed: July 29, 2008
    Date of Patent: January 7, 2014
    Assignee: Horiba ABX SAS
    Inventors: Roger Le Comte, Guilhem Couderc, Paul Moreno
  • Patent number: 8609038
    Abstract: Provided are a centrifugal force-based microfluidic device, in which biochemical treatments of samples are executed, and a method of fabricating the centrifugal force-based microfluidic device. The centrifugal force-based microfluidic device is mountable on a rotatable device and includes: a disk-shaped portion; and an inlet hole defined within, configured to receive fluid from outside the centrifugal force-based microfluidic device having a first opening with a first inner diameter, and a second opening disposed on the first opening having a second inner diameter greater than the first inner diameter, and a depth of the second opening greater than a height of a fluid droplet formable in the second opening.
    Type: Grant
    Filed: February 18, 2010
    Date of Patent: December 17, 2013
    Assignee: Samsung Electronics Co., Ltd.
    Inventors: Chung-ung Kim, Ki-ju Lee, Jong-jin Park, Dong-hwi Cho, Su-bong Bae, Jong-cheol Kim
  • Patent number: 8580210
    Abstract: A sample aspirating apparatus including a pipette which aspirates a sample, wherein the pipette is able to penetrate a cap of a capped container; a cap sensor which detects the cap of the capped container; a driving section which moves the pipette upward and downward; a crash sensor which detects a crash of the pipette with an obstacle; and a controller which controls the driving section to move the pipette, and stop the pipette when the crash sensor detects a crash by the pipette, wherein when aspirating a sample from a container after the cap sensor has detected a cap, the controller controls the driving section to move the pipette downward regardless of the detection by the crash sensor and thereby cause the pipette to penetrate the cap of the container. A sample analyzer which includes the above mentioned sample aspirating apparatus is also disclosed.
    Type: Grant
    Filed: August 16, 2011
    Date of Patent: November 12, 2013
    Assignee: Sysmex Corporation
    Inventors: Hironori Katsumi, Jun Inagaki
  • Patent number: 8545760
    Abstract: A specimen analyzing method and a specimen analyzing apparatus capable of measuring interference substances before analyzing a specimen. The method comprises a step for sucking the specimen stored in a specimen container (150) and sampling it in a first container (153), a step for optically measuring the specimen in the first container, a step for sampling the specimen in a second container (154) and preparing a specimen for measurement by mixing the specimen with a reagent in the second container, and a step for analyzing the specimen for measurement according to the results of the optical measurement of the specimen.
    Type: Grant
    Filed: September 28, 2007
    Date of Patent: October 1, 2013
    Assignee: Sysmex Corporation
    Inventors: Norimasa Yamamoto, Takashi Yamato, Naohiko Matsuo, Satoshi Iguchi
  • Publication number: 20130243665
    Abstract: Disclosed therein is a sampler. The sampler includes: a chamber accommodating a fluid or solid reagent therein and being sealed at both ends with penetrable films; a tube joined with the chamber at one side, the tube having a hollow portion therein; and a movable bar having a tip which is formed at one end and has a specimen extracting portion, the tip being guided and moved through a hollow portion, the tip being adapted for mixing the specimen extracted by the specimen extracting portion with the reagent so as to form a diluted solution while penetrating through one end of the chamber and adapted for quantitatively discharging out the diluted solution while penetrating through the other end of the chamber.
    Type: Application
    Filed: December 1, 2011
    Publication date: September 19, 2013
    Applicant: NANOENTEK ,INC.
    Inventors: Dae-Sung Hur, Ji-Young Park
  • Publication number: 20130208558
    Abstract: A reagent preparation assembly includes a body and a reaction chamber adjacent the body, the reaction chamber includes a reagent therein, such as a lyophilized reagent. An access port extends into the reaction chamber, and the access port is configured to receive an instrument. A seal extends across a portion of the reaction chamber and the access port. A reconstitution assembly is movably coupled with the body. The reconstitution assembly includes a plunger, a syringe and a piston. The plunger is movably coupled with the body. The syringe is selectively engaged with the plunger. The syringe includes a solution reservoir containing a solution, and movement of the syringe pierces the seal. The piston is selectively engaged with the plunger, and the piston is movably coupled within the syringe. Movement of the piston pushes the solution into the reaction chamber.
    Type: Application
    Filed: June 29, 2011
    Publication date: August 15, 2013
    Applicant: Biolyph LLC
    Inventors: Timothy Pearcy, James G. Skakoon
  • Publication number: 20130195734
    Abstract: A reagent bottle includes a reservoir adapted to contain a reagent, a pipette tip defining a fluid channel extending into the reservoir and a resilient seal fixedly disposed within the reservoir and surrounding the pipette tip, the seal functioning to reduce reagent loss when the pipette tip is withdrawn from the reagent bottle. The fluid channel of the pipette tip is defined by the pipette tip being in direct fluid communication, or interrupted fluid communication, with the exterior of the reagent bottle, the pipette tip being directly or indirectly engageable through a fluid-tight fitting with a pipette. A base member of the reagent bottle is adapted for selective engagement with one or more rotation pin and has an indexing feature for properly aligning the reagent bottle within an automated system. The base member adapted for selective engagement with one or more spring pins for raising and lowering the reagent bottle.
    Type: Application
    Filed: December 28, 2012
    Publication date: August 1, 2013
    Applicant: THERMO SHANDON LIMITED
    Inventor: THERMO SHANDON LIMITED
  • Patent number: 8470153
    Abstract: A cartridge (1) comprises a working film (10) for manipulating samples in liquid droplets with an electrode array (20) when the working film (10) of the cartridge (1) is placed on said electrode array (20).
    Type: Grant
    Filed: July 22, 2011
    Date of Patent: June 25, 2013
    Assignee: Tecan Trading AG
    Inventors: Marc N. Feiglin, Joseph Mamone, Anne R. Kopf-Sill, Ian Fitzpatrick, Mark Rob, Phillip Duncan
  • Patent number: 8470266
    Abstract: Provided is a sample packing device for packing a sample with respect to a microchip for performing reaction of a micro component contained in the sample, the microchip at least including: a sample reservoir; a reaction reservoir; and a channel connected between the sample reservoir and the reaction reservoir, in which a package including a sample chamber packed in advance with the sample is mounted on the microchip so as to pack the sample in the sample chamber into the sample reservoir.
    Type: Grant
    Filed: September 5, 2008
    Date of Patent: June 25, 2013
    Assignee: NEC Corporation
    Inventors: Minoru Asogawa, Hisashi Hagiwara, Tohru Hiramatsu
  • Patent number: 8415141
    Abstract: The invention relates to a method for rapid detection of a target nucleic acid amplification product while preventing cross-contamination between target nucleic acid amplification products and avoiding false positives, comprising the steps of: a) leaving the reaction tube unopened after the amplification reaction is finished, so as to prevent the target nucleic acid amplification product from leaking out and resulting in contamination; b) placing the unopened reaction tube inside an enclosed unit, making the target nucleic acid amplification product be transferred to a test strip from the reaction tube in a physically enclosed environment; c) performing detection in a visual read-out manner, and determining the result; d) discarding the enclosed unit in a safety place as a whole without opening it after the detection.
    Type: Grant
    Filed: August 12, 2008
    Date of Patent: April 9, 2013
    Inventors: Qimin You, Lin Hu, Jiayong Gu, Qinhao Yu
  • Patent number: 8404489
    Abstract: A nucleic acid extraction kit, which enables the nucleic acid extraction operation to be accomplished safely without causing contamination, and in which the complex preparation of reagents and the disposal treatments that are performed before and after the nucleic acid extraction operation can be performed rapidly and simply, with the extraction performed in an automated manner. The nucleic acid extraction kit includes: a container including reagent wells that each store at least a reagent, a sample well into which a biological sample is introduced, a waste liquid well, and a collection well in which an extracted nucleic acid is collected, and an extraction filter cartridge equipped with an extraction filter for separating and extracting a nucleic acid from the biological sample, wherein the extraction filter cartridge is formed in a manner that enables the extraction filter cartridge to be supported on the waste liquid well and the collection well.
    Type: Grant
    Filed: May 20, 2010
    Date of Patent: March 26, 2013
    Assignee: Toppan Printing Co., Ltd.
    Inventors: Shuichi Akashi, Ryoichi Asai
  • Patent number: 8404492
    Abstract: In a machine for manipulating toxic substances, an anthropomorphic robot transfers a container, which has a mouth closed by a cap made of perforable material, from a magazine for containers to a dosage station, set in which is a syringe provided with a needle, axially aligns the mouth with the needle, correcting the position of the mouth according to the position of the tip of the needle obtained from processing a number of images of the needle acquired from at least two distinct observation points, and finally approaches the container to the syringe in such a way that the needle perforates the cap and penetrates into the container to be able to inject or extract a substance into or out of the container.
    Type: Grant
    Filed: November 21, 2007
    Date of Patent: March 26, 2013
    Assignee: Health Robotics S.R.L.
    Inventors: Daniele Baldassari, Alferino Gabbarini, Paolo Giribona, Werner Rainer
  • Publication number: 20130065256
    Abstract: An assay apparatus comprising: i) an assay cartridge (52, 53) comprising at least one well (57-62) and a pipette (50) positionable in at least one said well; ii) a holder arranged to received said cartridge; iii) drive means operable to position said pipette in selected wells of said cartridge; iv) a gas pressure applicator couplable to said pipette whereby to cause liquid flow through said membrane; and v) a radiation detector operable to detect radiation from a well of said cartridge of said cartridge or from said pipette.
    Type: Application
    Filed: September 14, 2012
    Publication date: March 14, 2013
    Applicant: AXIS-SHIELD AS
    Inventors: Jostein HOLTLUND, Stig Morten Borch, Thorstein Seim, Tore Janson, Hege Tøn, Jan Roger Karlson, Inger Lise Lauvstad
  • Publication number: 20130045527
    Abstract: A delivery apparatus for selectively delivering one or more liquid reagents into a reaction or test chamber (2), especially of an assay apparatus, the apparatus comprising: one or more respective storage chambers (5,6) for containing the one or more liquid reagents and arranged generally above the reaction or test chamber (2); and a plunger element (4) arranged and operable for insertion into the mouth of a selected storage chamber so as to displace a selected reagent from therewithin into the reaction or test chamber (2) generally therebelow by gravitational liquid overflow from the mouth of the chamber. The apparatus may conveniently be provided as a discrete delivery unit, with the storage chambers (5,6) pretilled with the selected reagents.
    Type: Application
    Filed: October 23, 2012
    Publication date: February 21, 2013
    Inventor: David James Squirrell
  • Patent number: 8349278
    Abstract: Apparatus (1) for withdrawing respective liquid samples from vials (2) which are closed by closure caps (4) includes a plurality of racks (7) for accommodating the vials (2). A device (10) including a housing (25) is slideably carried on a gantry (9) which in turn is slideably carried on guide tracks (12) to provide two degrees of movement of the device (10) for selective alignment of the device (10) with the vials (2). An abutment member (43) is driven vertically by a second gearwheel (51) by a drive shaft (27) through a first gearwheel (40) and a dog clutch (52). A cannula which is secured within a first gear rack (33) is driven vertically by the first gearwheel (40). On engagement of the abutment member (43) with the closure cap (4) of the selected vial (2), the clutch (52) decouples the second gearwheel (51) from the first gearwheel (40) so that the cannula (28) is urgeable through the closure cap (4) into the vial (2).
    Type: Grant
    Filed: November 15, 2007
    Date of Patent: January 8, 2013
    Assignee: TCOAG Ireland Limited
    Inventors: Ronan Patrick O'Caoimh, James Walsh, Brendan Kevin Farrell, Rory Peter Nealon, Josef Georg Hubert Wiehe
  • Patent number: 8337779
    Abstract: A reagent open mechanism of the luminescence measurement system comprises a triaxial actuator and a reagent dispensing nozzle which is driven by the triaxial actuator. A reagent cartridge where a reagent to be divided by the reagent dispensing nozzle is filled in a concave and the opening of the concave is sealed by an aluminum sheet can be set in. This reagent open mechanism comprises an open needle which is driven by the triaxial actuator and makes a hole in the aluminum sheet and a fixation block between the reagent dispensing nozzle and the open needle which arranges the reagent dispensing nozzle and the open needle in such location that the reagent dispensing nozzle or the open needle does not contact with a structure including the reagent cartridge in a Z-axis operation during opening time or reagent dividing and dispensing time.
    Type: Grant
    Filed: December 21, 2010
    Date of Patent: December 25, 2012
    Assignee: Hitachi Plant Technologies, Ltd.
    Inventor: Noe Miyashita
  • Patent number: 8329114
    Abstract: Devices, instruments, systems and methods are provided in which a primary line that receives a biological fluid is selectively sampled by a plurality of collection chambers. Selective sampling occurs by selectively accessing the primary line and selective engagement of a sampling pump under control of a microprocessor. Further, the instrument housing reversibly houses a drive assembly and sample collection housing to permit the interchangeability of drive assemblies and collection housings and thus enhance sterility or reduction of cost.
    Type: Grant
    Filed: March 18, 2009
    Date of Patent: December 11, 2012
    Assignee: Hemobotics, LLC
    Inventor: John Temple
  • Patent number: 8329119
    Abstract: A reagent preparation and dispensing device includes a body. A reagent reservoir containing a reagent is disposed within the body. A solution reservoir containing a solution is disposed within the body. The device further includes an activator movably coupled with the body to open the reagent reservoir and the solution reservoir. The activator is operable to mix the solution with the reagent to form a reagent mixture. A dispensing reservoir tip is coupled with the body. The dispensing reservoir tip is sized and shaped to dispense the reagent mixture from the device.
    Type: Grant
    Filed: April 18, 2012
    Date of Patent: December 11, 2012
    Assignee: Biolyph, LLC
    Inventors: Timothy Pearcy, James G. Skakoon
  • Patent number: 8327725
    Abstract: There is provided a sample collection container, a sample collection apparatus, and a sample collection method used in a supercritical fluid system capable of collecting a multi-constituent sample contained in a supercritical fluid at low cost and high collection efficiency. The pressure of a supercritical fluid containing a sample is reduced to a pressure close to the atmospheric pressure, and the depressurized supercritical fluid is forced to undergo adiabatic expansion to form gas-phase CO2 containing a liquid component in the form of aerosol. The gas-phase CO2 is fractionated for each constituent of the contained sample, transferred to a probe 60 of Liquid Handler, and dispensed into a large number of collection vials 300 under the atmospheric pressure, each of which is provided with a vial cap 100.
    Type: Grant
    Filed: September 26, 2009
    Date of Patent: December 11, 2012
    Assignee: JASCO Corporation
    Inventor: Takeshi Kanomata
  • Patent number: 8303895
    Abstract: An apparatus for controlling the temperature of a reaction mixture contained in a chamber of a reaction vessel comprises a thermal surface for contacting a flexible wall of the chamber and an automated machine for increasing the pressure in the chamber. The pressure increase in the chamber is sufficient to force the flexible wall to conform to the thermal surface for good thermal conductance. The apparatus also includes at least one thermal element for heating or cooling the surface to induce a temperature change within the chamber.
    Type: Grant
    Filed: November 25, 2008
    Date of Patent: November 6, 2012
    Assignee: Capheid
    Inventors: Ronald Chang, Douglas B. Dority, Lee A. Christel, Robert Yuan, Kurt E. Petersen
  • Patent number: 8298497
    Abstract: A delivery apparatus for selectively delivering one or more liquid reagents into a reaction or test chamber (2), especially of an assay apparatus, the apparatus comprising: one or more respective storage chambers (5,6) for containing the one or more liquid reagents and arranged generally above the reaction or test chamber (2); and a plunger element (4) arranged and operable for insertion into the mouth of a selected storage chamber so as to displace a selected reagent from therewithin into the reaction or test chamber (2) generally therebelow by gravitational liquid overflow from the mouth of the chamber. The apparatus may conveniently be provided as a discrete delivery unit, with the storage chambers (5,6) prefilled with the selected reagents.
    Type: Grant
    Filed: December 14, 2009
    Date of Patent: October 30, 2012
    Assignee: The Secretary of State for Defence
    Inventor: David James Squirrell
  • Patent number: 8268263
    Abstract: A self dispensing reagent cartridge includes a vessel with a movable piston at one end and a puncturable self sealing septum at an opposite end. A hollow needle is located in alignment with the septum. The vessel is moved toward the needle to enable the needle to puncture the septum. The piston is then moved toward the septum to enable a predetermined amount of liquid in the vessel to be transferred outwardly of the vessel through the needle in an amount corresponding to the piston stroke.
    Type: Grant
    Filed: August 27, 2008
    Date of Patent: September 18, 2012
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Adrian M. Campbell, Nicolae Dumitrescu
  • Publication number: 20120201726
    Abstract: A reagent preparation and dispensing device includes a body. A reagent reservoir containing a reagent is disposed within the body. A solution reservoir containing a solution is disposed within the body. The device further includes an activator movably coupled with the body to open the reagent reservoir and the solution reservoir. The activator is operable to mix the solution with the reagent to form a reagent mixture. A dispensing reservoir tip is coupled with the body. The dispensing reservoir tip is sized and shaped to dispense the reagent mixture from the device.
    Type: Application
    Filed: April 18, 2012
    Publication date: August 9, 2012
    Applicant: Biolyph, LLC
    Inventors: Timothy Pearcy, James G. Skakoon
  • Patent number: 8187558
    Abstract: A method for reducing or eliminating the aspiration of foam into a metering probe includes the steps of providing a reagent supply container having a baffle having sealed ends and having a liquid reagent in it. A metering probe movable in a direction toward and away from the reagent supply container is provided. A closure is moved away from the opening of the container and both seals covering the first and second openings of the baffle are pierced allowing liquid to enter the baffle from the end of the baffle submerged in the liquid thereby providing a foam reduced or foam free zone. The metering probe is moved into the first opening of the baffle and into contact with the liquid in the baffle. A selected amount of liquid in the baffle is aspirated and the metering probe is moved out of the baffle.
    Type: Grant
    Filed: July 12, 2010
    Date of Patent: May 29, 2012
    Assignee: Ortho-Clinical Diagnostics, Inc.
    Inventors: Merrit N. Jacobs, Nicholas Van Brunt
  • Patent number: 8163254
    Abstract: A micromanifold for connecting external capillaries to the inlet and/or outlet ports of a microfluidic device can employ a ferrule/capillary assembly that includes: (a) a ferrule comprising an elongated member and having a bore traversing from a proximal end to a distal end of the member, wherein the bore has an inner surface and wherein the distal end of the ferrule has a tapered, threaded exterior surface, and (b) a capillary that is positioned within the bore wherein the capillary's outer surface is in direct contact with the bore's inner surface. No mating sleeve is required for the one-piece ferrule. Alternatively, the capillaries can be bonded to channels that traverse the manifold and therefore obviate the need for a ferrule.
    Type: Grant
    Filed: June 1, 2009
    Date of Patent: April 24, 2012
    Assignee: Sandia Corporation
    Inventors: Ronald F. Renzi, Scott M. Ferko
  • Patent number: 8057762
    Abstract: A cap having a core structure dimensioned to receive a pipette therethrough. The cap includes two axially aligned frangible seals that are affixed to the core structure in a spaced-apart relationship. The frangible seals are constructed so that air passageways are formed between the frangible seals and a pipette tip when the pipette tip penetrates the frangible seals. The cap optionally includes a filter interposed between the first and second frangible seals.
    Type: Grant
    Filed: December 2, 2010
    Date of Patent: November 15, 2011
    Assignee: Gen-Probe Incorporated
    Inventors: Daniel L. Kacian, Mark R. Kennedy, Nick M. Carter
  • Patent number: RE45194
    Abstract: A cap having a core structure dimensioned to receive a pipette therethrough. The cap includes two axially aligned frangible seals that are affixed to the core structure in a spaced-apart relationship. The frangible seals are constructed so that air passageways are formed between the frangible seals and a pipette tip when the pipette tip penetrates the frangible seals. The cap optionally includes a filter interposed between the first and second frangible seals.
    Type: Grant
    Filed: November 8, 2013
    Date of Patent: October 14, 2014
    Assignee: Gen-Probe Incorporated
    Inventors: Daniel L. Kacian, Mark R. Kennedy, Nick M. Carter