Miscellaneous Laboratory Apparatus And Elements, Per Se Patents (Class 422/500)
  • Patent number: 10766160
    Abstract: A glass panel unit manufacturing method includes a punching step and a pillar mounting step. In the punching step, a punch punches at least one of a plurality of portions from a base material of a sheet to form at least one pillar. Each of the plurality of portions is surrounded by a corresponding one of a plurality of loop-shaped grooves in the base material. In the pillar mounting step, the at least one pillar is mounted on a surface of a first substrate including a glass pane.
    Type: Grant
    Filed: November 10, 2017
    Date of Patent: September 8, 2020
    Inventors: Takeshi Shimizu, Hiroyuki Abe, Masataka Nonaka, Kazuya Hasegawa, Eiichi Uriu, Haruhiko Ishikawa, Tasuku Ishibashi, Hiroshi Takahashi, Shinobu Watanabe
  • Patent number: 10730040
    Abstract: Pipette tip couplers, pipette tips, coupler and tip combinations, and methods for coupling and decoupling a pipette tip to or from an expanding mandrel pipette tip coupler mounted on a pipette device. The pipette tip couplers include circumferentially spaced apart segments for engaging an interior surface of a pipette tip, an annular base disposed below the segments, a distal elastomeric element disposed around a distal stem portion for sealing against the interior surface of the pipette tip, upwardly extending circumferentially spaced apart arms each supporting a different segment, and a stop disk for abutting a stop shoulder in a pipette tip. The pipette tips include a groove in a first cylindrical section, a second cylindrical section, a pipette tip stop shoulder surface, a third cylindrical section, and a sealing seat surface.
    Type: Grant
    Filed: July 17, 2019
    Date of Patent: August 4, 2020
    Assignee: Hamilton Company
    Inventors: Jose Eduardo Guzman, Thomas Barresi, Dana A. Belton
  • Patent number: 10709356
    Abstract: A chemical extraction apparatus has absorbent material for absorbing or adsorbing volatile chemicals from a breath of a user. The chemical extraction apparatus is positioned within such that breaths from the user flow over the absorbent material thereby causing volatile chemicals in the breaths to absorb or adsorb into the absorbent material. The absorbent material is then analyzed to determine the amount of chemicals absorbed or adsorbed into the absorbent material. Based on such analysis, various diseases or conditions can be detected or diagnosed.
    Type: Grant
    Filed: September 29, 2016
    Date of Patent: July 14, 2020
    Assignee: Volatile Analysis Corporation
    Inventors: Russell Bazemore, Kathy Bazemore
  • Patent number: 10682642
    Abstract: Pipette tip couplers, pipette tips, coupler and tip combinations, and methods for coupling and decoupling a pipette tip to or from a pipette tip coupler mounted on a pipette device. The pipette tip couplers include a proximal elastomeric element, a distal elastomeric element, and a coupler stop shoulder surface between the elastomeric elements. The pipette tips include a groove in a first cylindrical section, a second cylindrical section, a tip stop shoulder surface at the interface of the first and second cylindrical sections, a third cylindrical section distal to the second cylindrical section, and a sealing seat surface at the interface of the second and third cylindrical sections. When the pipette tip is mounted on the pipette tip coupler, the proximal elastomeric element abuts the tip groove, the coupler stop shoulder surface abuts the tip stop shoulder surface, and the distal elastomeric element abuts the sealing seat surface.
    Type: Grant
    Filed: July 24, 2019
    Date of Patent: June 16, 2020
    Assignee: Hamilton Company
    Inventors: Jose Eduardo Guzman, Thomas Barresi, Dana A. Belton
  • Patent number: 10544457
    Abstract: The present invention provides methods, compositions, and systems for enriching compositions for polymerase enzyme complexes. In particular, the methods, compositions, and systems of the present invention remove free polymerases from the compositions using one or more purification steps, including protease treatment, thus enriching the compositions for polymerases complexed with a template nucleic acid.
    Type: Grant
    Filed: June 9, 2017
    Date of Patent: January 28, 2020
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: Erik Miller, Keith Bjornson, Kristofor Nyquist, Satwik Kamtekar
  • Patent number: 10525460
    Abstract: Pipette assembly comprising a pipette device, a pipette tip, and an expanding mandrel collet coupling device coupling the tip to the pipette device, the coupling device comprising: circumferentially spaced apart segments, an annular base disposed below the segments and comprising a distal portion, an elastomeric element circumscribing the distal portion, and upwardly extending circumferentially spaced apart arms attached at first ends to the annular base and having upper free ends each supporting a different one of the segments configured to expand between a first and a second greater circumference for engaging a first interior working surface of the tip in concurrence with the elastomeric element sealing against a second interior working surface below the first surface and in concurrence with an abutment between a disk exteriorly disposed about a medial portion of the arms and a stepped interior shoulder of the tip disposed between the first and second working surfaces.
    Type: Grant
    Filed: November 10, 2016
    Date of Patent: January 7, 2020
    Assignee: Hamilton Company
    Inventors: Jose Eduardo Guzman, Thomas Barresi, Dana A. Belton
  • Patent number: 10449534
    Abstract: A control unit for controlling a pipetting machine a pipetting machine, and a method for controlling a pipetting machine, wherein the control unit controls at least one actuator for moving a pipetting device between receptacle units for liquids to be pipetted and for receiving or dispensing liquids to be pipetted. The control unit, by selecting one or more graphic receptacle unit equivalents which correspond to receptacle units, assigns at least one transfer parameter to the receptacle unit equivalents. The transfer parameter corresponds to a transfer volume, which is to be received from the receptacle unit corresponding to the respective receptacle unit equivalent or is to be dispensed into the receptacle unit corresponding to the respective receptacle unit equivalent. The control unit is additionally designed so that selected source receptacle unit equivalents are simultaneously assignable to multiple target receptacle unit equivalents.
    Type: Grant
    Filed: November 16, 2015
    Date of Patent: October 22, 2019
    Assignee: BRAND GMBH + CO KG
    Inventors: Christian Berberich, Jürgen Schraut, Michael Zugelder, Thomas Howe
  • Patent number: 10189254
    Abstract: A droplet ejecting head includes a board, a pressure chamber, a nozzle, and an actuator configured to cause a pressure change in the pressure chamber in response to an electrical signal supplied from a drive circuit. The drive circuit is configured to set the electrical signal at a first voltage level, change the electrical signal to a second voltage level, set the electrical signal to a third voltage level during a time period after changing the electrical signal from the first voltage level to the second voltage level, the time period being equal to a primary natural oscillation period of the actuator when the pressure chamber and the nozzle are filled with solution, and set the electrical signal to the first voltage level after the time period has elapsed. The third voltage level is between the first and second voltage levels or equal to the second voltage level.
    Type: Grant
    Filed: August 24, 2017
    Date of Patent: January 29, 2019
    Inventors: Shuhei Yokoyama, Ryutaro Kusunoki, Ikuo Fujisawa
  • Patent number: 10139134
    Abstract: A microchip includes a vessel portion, an elastic member, and a flow channel which leads a liquid sample to the vessel portion. After a liquid sample is put in the vessel portion, the liquid sample is heated while pressure is applied with respect to an inner portion of the vessel portion.
    Type: Grant
    Filed: December 19, 2011
    Date of Patent: November 27, 2018
    Inventors: Minoru Asogawa, Hisashi Hagiwara
  • Patent number: 9909984
    Abstract: The present invention provides a multichannel label-free biosensing fiber-optic system, which comprises one or more light sources coupled into optical fibers, one or more optical fiber circuits for performing coupling or/and directional transmission of optical-fiber guided lightwaves, one or more optical-fiber-input and optical-fiber-output optical switches, a plurality of optical fibers provided with label-free optical sensing elements working in the reflection manner on the optical fiber ends, and the light detection parts, wherein the optical-fiber-input and optical-fiber-output optical switch is provided with a plurality of outputs and/or a plurality of inputs, and with the plurality of outputs and/or plurality of inputs, by the switching function, the reflected light from the label-free optical sensing elements working in the reflection manner on the designated optical fiber ends is received by the light detection part, so that multichannel sensing is realized.
    Type: Grant
    Filed: February 10, 2016
    Date of Patent: March 6, 2018
    Inventor: Tian Yang
  • Patent number: 9815959
    Abstract: A method for manufacturing a hollow particle is provided. The method comprises the steps of (a) providing a hollow particulate; (b) soaking the hollow particulate in an amine solution to form amine groups on the surface of the hollow particulate; (c) adding a polypeptide, and the polypeptide is linked to the amine groups on the surface of the hollow particulate; and (d) adding a target molecule, and the target molecule is bound to the amine group which are still not bound.
    Type: Grant
    Filed: February 26, 2015
    Date of Patent: November 14, 2017
    Inventors: Jui-Yang Lai, Kao-Yuan Chang, Zih-Han Hong, Po-Cheng Lin, Ming-Hsi Chuang
  • Patent number: 9724688
    Abstract: An isolator system including: a box-shaped body case having, in an interior thereof, a work space for operation in a sterile environment and also having, in a front surface thereof, an insertion portion into which a worker's arm is inserted; and an air-conditioning portion configured to supply gas in the work space of the body case or to discharge gas in the work space, a bottom of the work space being configured with a work plate, a discharge path configured to discharge gas in the work space being formed below the work plate, the work plate being configured with first and second work plates obtained by dividing the work plate into right and left parts, a receiving portion being located below the first work plate, the receiving portion being arranged extending towards the second work plate on a side edge of the first work plate, the side edge of the first work plate being in contact with the second work plate, a side edge of the second work plate for being in contact with the first work plate being placed de
    Type: Grant
    Filed: February 26, 2016
    Date of Patent: August 8, 2017
    Inventors: Koichi Kobayashi, Yasuhiko Yokoi, Hironobu Sekine
  • Patent number: 9696241
    Abstract: The present invention provides a liquid sampling, storage, transfer and delivery device comprising housing containing a porous nib. The porous nib in the device contacts the sample, collects the sample, stores the sample, transports the sample inside its porous matrix and releases the sample from the porous matrix upon demand.
    Type: Grant
    Filed: August 11, 2016
    Date of Patent: July 4, 2017
    Inventors: Guoqiang Mao, James P. Wingo
  • Patent number: 9688952
    Abstract: A micro fluid dosing unit includes a test container containing biomaterial needing oxygen. The test container has at least one first container which contains water and at least one second container which contains a pharmacological substance, wherein the first and the second containers have a container outlet leading to the test container and are mounted on a common valve carrier plate containing control channels, which includes control channel ports for control valves to be coupled thereto. In the valve carrier plate a separate valve control chamber is formed for each container, which is sealed by a membrane, wherein associated container outlets are opened and closed by the membrane movement.
    Type: Grant
    Filed: July 8, 2014
    Date of Patent: June 27, 2017
    Assignee: Buerkert Werke GmbH
    Inventor: Peggy Schaefer
  • Patent number: 9656262
    Abstract: Microfluidic devices have been developed to perform a range of high-throughput biochemical and cell-based assays over recent years. A design for a microfluidic device has been developed that resembles a microtiter plate, by placing the test chambers (each test chamber contains cells) and top-loading drug inlets (at least one per test chamber) in a grid according to the ANSI/SBS standards, yet offers the miniaturization and fluid handling advantages of microfluidics. This ensures that the device design is compatible with fluid handling and imaging equipment already in use for drug screening. A range of topologies have been determined that allow placement of various elements of this microfluidic network within the grid alignment constraints. A resistance equalization methodology has also been developed to reduce variability across assays run in different chambers of the microfluidic device.
    Type: Grant
    Filed: June 10, 2014
    Date of Patent: May 23, 2017
    Inventors: Saurabh Paliwal, Zhizhong Yin, Raymond Cheong
  • Patent number: 9480986
    Abstract: An improved deposition aid for manual sample preparation, particularly on flat MALDI sample supports, comprises a holder for a sample support with several sample sites, which is adapted to standardized sample supports for ionization with matrix-assisted laser desorption and a device which projects a two-dimensional optical image, or a suitable sequence of images, onto the sample sites. The image, or sequence of images, is constructed such that a selected sample site or group of selected sample sites is highlighted in a way which can be perceived by the human eye, at least with respect to neighboring, not-selected sample sites. The deposition aid also includes an interface for confirming the manual deposition and/or a device for the automatic detection of a manual deposition process; and a guidance system which selects a sample site or group of sample sites, and controls the device accordingly.
    Type: Grant
    Filed: September 24, 2012
    Date of Patent: November 1, 2016
    Inventors: Christian Schmid, Martin Schürenberg
  • Patent number: 9421541
    Abstract: A microfluidic apparatus that is mounted on a rotation driver and induces a flow of a fluid according to a centrifugal force includes a lower structure having a microfluidic structure including a recovery chamber for accommodating a target material separated from a sample and a channel for forming an inflow path of the target material to the recovery chamber; an upper plate forming an upper wall of the recovery chamber and the channel; and a lid formed integrally to the upper plate and removable from the upper plate to open at least a part of a top of the recovery chamber.
    Type: Grant
    Filed: December 30, 2013
    Date of Patent: August 23, 2016
    Inventors: Hui-sung Moon, Min-Seok S. Kim, Jong-myeon Park
  • Patent number: 9259737
    Abstract: A lab member for use in a laboratory liquid handling system including a pipetting module and a drive system, the pipetting module including first and second pipettors, the first and second pipettors including first and second pipettor shafts, respectively, a first pipetting tip extending from an end of the first pipettor shaft, and a second pipetting tip extending from an end of the second pipettor shaft, includes a lab object and first and second integral adapter structures. The first and second adapter structures are configured to engage the first and second pipettor shafts, respectively. The first adapter structure is configured to releasably secure the lab member to the first pipettor shaft.
    Type: Grant
    Filed: June 24, 2014
    Date of Patent: February 16, 2016
    Assignee: PerkinElmer Health Sciences, Inc.
    Inventors: Lee Brady, Larry Schoell, Gary Millard, Richard R. Harazin
  • Patent number: 9212980
    Abstract: A fluid control and processing system for controlling fluid flow among a plurality of chambers comprises a body including a fluid processing region continuously coupled fluidicly with a fluid displacement region. The fluid displacement region is depressurizable to draw fluid into the fluid displacement region and pressurizable to expel fluid from the fluid displacement region. The body includes at least one external port. The fluid processing region is fluidicly coupled with the at least one external port. The fluid displacement region is fluidicly coupled with at least one external port of the body. The body is adjustable with respect to the plurality of chambers to place the at least one external port selectively in fluidic communication with the plurality of chambers.
    Type: Grant
    Filed: January 31, 2014
    Date of Patent: December 15, 2015
    Assignee: Cepheid
    Inventors: Douglas Dority, Ronald Chang
  • Patent number: 9075042
    Abstract: A clinical diagnostic system is disclosed, including a clinical diagnostic instrument with a disposable cartridge. The disposable cartridge is capable of performing diagnostic and analytical functions including filtering samples such as plasma from whole blood and running assays and collecting measurements of analytes or biomarkers.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: July 7, 2015
    Assignee: Wellstat Diagnostics, LLC
    Inventors: Richard Alan Cook, Charles Quentin Davis, Jason Charles Harley, Jonathan Leland, Rober Krikor Matikyan, Jeffrey Howard Peterman
  • Publication number: 20150141470
    Abstract: A method of identifying a subject having cancer who is likely to benefit from treatment with a combination therapy with a MAPK pathway inhibitor, such as a RAF inhibitor, MEK inhibitor, or ERK inhibitor, and a GEF or HDAC inhibitor is provided. A method of treating cancer in a subject in need thereof is also provided and includes administering to the subject an effective amount of a MAPK inhibitor, such as a RAF inhibitor, MEK inhibitor, or ERK inhibitor, and an effective amount of a GEF or HDAC inhibitor. A method of identifying targets that confers resistance to a MAPK pathway inhibitor is also provided.
    Type: Application
    Filed: May 8, 2013
    Publication date: May 21, 2015
    Applicants: The Broad Institute, Inc., Dana-Farber Cancer Institute, Inc.
    Inventors: Levi A. Garraway, Cory M. Johannessen
  • Patent number: 9034259
    Abstract: One embodiment of the present invention is to provide a system for sorting cell particles in a liquid flow, which comprises a flow-defining block including a flow chamber receiving a sample conduit and a flow cell having a flow channel. The system also comprises a strobe block including a imaging device for taking an image of a jet flow ejected from the flow-defining block and a plurality of droplets in a given image area. The flow-defining block and the strobe block are detachably connected each other. Further the strobe block includes a nozzle plate having a nozzle channel between a receiving end and a nozzle. The flow-defining block includes a discharge end opposite to the receiving end and a channel enlarged portion of which cross section taken along a predetermined plane perpendicular to a flow direction has an area increasing towards the discharge end. The discharge end and the receiving end have substantially the same open distance in the predetermined plane perpendicular to the flow direction.
    Type: Grant
    Filed: April 20, 2011
    Date of Patent: May 19, 2015
    Inventor: Masahiko Kanda
  • Patent number: 9028779
    Abstract: The device for the transfer of a medium comprises a magazine (2) and at least one transfer element (3) for transfer of said medium, said transfer element (3) comprising a duct (45) for transfer of said medium provided at one end with a needle (31), a septum (32), and a maneuvering unit (33) of said needle (31), said transfer element (3) also comprising means for locking (61, 65) adapted to cooperate with complementary locking means (15) of said magazine (2) to lock said needle (31) in a waiting position, said locking means (61, 62, 65) belonging to said maneuvering unit (33) and cooperating with said complementary locking means (15) at a location of said magazine (2) distinct from the location through which said duct (45) issues from the cavity (20), at the opposite end from the needle (31).
    Type: Grant
    Filed: December 15, 2009
    Date of Patent: May 12, 2015
    Assignee: EMD Millipore Corporation
    Inventor: Stephane Olivier
  • Patent number: 9028756
    Abstract: A specimen analyzing method and a specimen analyzing apparatus capable of measuring interference substances before analyzing a specimen. The method comprises a step for sucking the specimen stored in a specimen container (150) and sampling it in a first container (153), a step for optically measuring the specimen in the first container, a step for sampling the specimen in a second container (154) and preparing a specimen for measurement by mixing the specimen with a reagent in the second container, and a step for analyzing the specimen for measurement according to the results of the optical measurement of the specimen.
    Type: Grant
    Filed: August 30, 2013
    Date of Patent: May 12, 2015
    Assignee: Sysmex Corporation
    Inventors: Norimasa Yamamoto, Takashi Yamato, Naohiko Matsuo, Satoshi Iguchi
  • Patent number: 9028773
    Abstract: A system and method for reducing the number of input/output connections required to connect a microfluidic substrate to an external controller for controlling the substrate. In one example, a microfluidic processing device is fabricated on a substrate having a plurality of N independently controllable components, (e.g., a resistive heating elements) each having at least two terminals. The substrate includes a plurality of input/output contacts for connecting the substrate to an external controller, and a plurality of leads for connecting the contacts to the terminals of the components. The leads are arranged to allow the external controller to supply control signals to the terminals of the components via the contacts using substantially fewer contacts than the total number of component terminals.
    Type: Grant
    Filed: March 28, 2014
    Date of Patent: May 12, 2015
    Assignee: Handylab, Inc.
    Inventor: Karthik Ganesan
  • Publication number: 20150108688
    Abstract: A resin dispenser for nano-imprinting includes a housing including a lower chamber in which a resin is filled, a slit defined in a lower part of the lower chamber and through which the resin is discharged, and an upper chamber in which a pressure-applying fluid is filled, and a membrane separating the lower and upper chambers from each other, and of which an edge is fixed on a middle part of the housing, where the fluid is configured to apply the pressure to the membrane and protrude the membrane toward the slit of the lower chamber.
    Type: Application
    Filed: June 18, 2014
    Publication date: April 23, 2015
    Inventors: Bong-su SHIN, Dong-ouk KIM, Joon-young PARK, Sung-hoon LEE, Jae-seung CHUNG, Suk-gyu HAHM, Dae-young LEE, Gug-rae JO
  • Patent number: 9011795
    Abstract: Provided are a valve unit and a microfluidic device including the valve unit. The valve unit includes: a valve substance container containing a valve substance, the valve substance including a phase change material that is solid at ambient temperature and melts by absorbing energy; a valve connection path connecting the valve substance container to a channel forming a fluid passage; and a pair of drain chambers formed along the channel at both sides of the valve connection path.
    Type: Grant
    Filed: November 8, 2007
    Date of Patent: April 21, 2015
    Assignee: Samsung Electronics Co., Ltd.
    Inventors: Beom-seok Lee, Yoon-kyoung Cho, Jeong-gun Lee, Jong-myeon Park
  • Patent number: 9011775
    Abstract: Disclosed herein is a cation exchange capacity titration unit comprising a titration cell having a closed bottom end in fluid communication with an open top end; a recirculation loop comprising a pump and a sensing unit, wherein the pump comprises a pump inlet in fluid communication with the bottom end of the titration cell, and a pump outlet in fluid communication with a sensing unit inlet, the sensing unit inlet being in fluid communication with a sensing unit outlet, wherein the sensing unit outlet is in fluid communication with the top end of the titration cell such that operation of the pump results in an analyte sample flowing from the bottom end through the pump, through the sensing unit, and back into the top end of the titration cell in a continuous loop. A method of determining the cation exchange capacity of a sample is also disclosed.
    Type: Grant
    Filed: January 25, 2010
    Date of Patent: April 21, 2015
    Assignee: M-I L.L.C.
    Inventors: George McMennamy, Marian Baranowski, Arkadiy Belkin
  • Patent number: 9005542
    Abstract: The storage arrangement has a chamber. Several Dewar flasks are arranged in the chamber and above them a picking device. The picking device has at least one cassette lift, with which storage cassettes can be removed from above from the Dewar flasks. This arrangement is suitable for storing laboratory objects at very low temperatures.
    Type: Grant
    Filed: November 23, 2011
    Date of Patent: April 14, 2015
    Assignee: Liconic AG
    Inventor: Cosmas G. Malin
  • Patent number: 8999264
    Abstract: A coating formula and method for surface coating non-porous surfaces. Microfluidic devices including said coating achieve desired properties including increased hydrophilicity, improved adhesion, stability and optical clarity.
    Type: Grant
    Filed: September 26, 2011
    Date of Patent: April 7, 2015
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventor: Michael J. Pugia
  • Patent number: 8992858
    Abstract: A microfluidic device comprises pumps, valves, and fluid oscillation dampers. In a device employed for sorting, an entity is flowed by the pump along a flow channel through a detection region to a junction. Based upon an identity of the entity determined in the detection region, a waste or collection valve located on opposite branches of the flow channel at the junction are actuated, thereby routing the entity to either a waste pool or a collection pool. A damper structure may be located between the pump and the junction. The damper reduces the amplitude of oscillation pressure in the flow channel due to operation of the pump, thereby lessening oscillation in velocity of the entity during sorting process. The microfluidic device may be formed in a block of elastomer material, with thin membranes of the elastomer material deflectable into the flow channel to provide pump or valve functionality.
    Type: Grant
    Filed: August 21, 2007
    Date of Patent: March 31, 2015
    Assignee: The United States of America National Institute of Health (NIH), U.S. Dept. of Health and Human Services (DHHS)
    Inventors: Hou-Pu Chou, Anne Y. Fu, Stephen R. Quake
  • Patent number: 8986611
    Abstract: A sample analysis apparatus configured to automatically press a start button upon installation of a sample tube is provided. The sample analysis apparatus includes: a body of the sample analysis apparatus; a door housing which may be provided in an opened state or a closed state, and configured to be coupled to the body of the sample analysis apparatus by a hinge; a tube accommodating unit included in the door housing and configured to accommodate the sample tube; a start button included in the body of the sample analysis apparatus and configured to start analysis of the sample; and an operating member positioned at a first position which is distant from the start button the sample tube is not installed in the tube accommodating unit, and a second position which is configured to operate the start button when a sample tube is installed and the door housing is closed.
    Type: Grant
    Filed: August 2, 2012
    Date of Patent: March 24, 2015
    Assignee: Samsung Electronics Co., Ltd.
    Inventors: Yong Koo Lee, Tae Soo Kim, In Duk Hwang, Seock Woo Jang, Chul Ho Yun
  • Publication number: 20150079668
    Abstract: Provided is a fluidic device including: a support member; a porous layer; and an adhesive layer bonding the support member and the porous layer with each other. A partition wall made of a thermoplastic material is formed in the porous layer. The support member has a heatproof temperature that is higher than a melting start temperature of the thermoplastic material.
    Type: Application
    Filed: September 19, 2014
    Publication date: March 19, 2015
    Inventor: Rie KOBAYASHI
  • Patent number: 8979358
    Abstract: A mixing device for liquid chromatography for the radial mixing of at least two fluids comprises a tubular mixing line, and a helical flow-guiding element arranged in the mixing line. One or more spacing elements located within an interior region of the mixing line are adapted to maintain a predetermined distance between the outer sides of the helical flow-guiding element and an inner wall of the mixing line. A mixing unit according to the present invention may include such a radial mixing device, with a longitudinal mixing device being connected downstream from this radial mixing device.
    Type: Grant
    Filed: July 31, 2009
    Date of Patent: March 17, 2015
    Assignee: Dionex Softron GmbH
    Inventor: Joachim Wiechers
  • Patent number: 8980199
    Abstract: Embodiments described herein provide micro-fluidic systems and devices for use in performing various diagnostic and analytical tests. According to one embodiment, the micro-fluidic device includes a sample chamber for receiving a sample, and a reaction chamber for performing a chemical reaction. A bubble jet pump is structured on the device to control delivery of a fluid from the sample chamber to the reaction chamber. The pump is fluidically coupled to one or more chambers of the device using a fluidic channel such as a capillary. A valve may be coupled to one or more chambers to control flow into and out of those chambers. Also, a sensor may be positioned in one or more of the chambers, such as the reactant chamber, for sensing a property of the fluid within the chamber as well as the presence of a chemical within the chamber.
    Type: Grant
    Filed: March 25, 2014
    Date of Patent: March 17, 2015
    Assignee: InCube Labs, LLC
    Inventor: Mir Imran
  • Patent number: 8974751
    Abstract: Sample liquid is collected in a chamber downstream of a separating device. Adjoining the chamber are a plurality of channels which guide the sample liquid to one or more investigating regions.
    Type: Grant
    Filed: July 5, 2011
    Date of Patent: March 10, 2015
    Assignee: Boehringer Ingelheim Microparts GmbH
    Inventors: Tobias Rodenfels, Gert Blankenstein
  • Patent number: 8975193
    Abstract: A microfabricated device is fabricated by depositing a first metal layer on a substrate to provide a first electrode of an electrostatic actuator, depositing a first structural polymer layer over the first metal layer, depositing a second metal layer over said first structural polymer layer to form a second electrode of the electrostatic actuator, depositing an insulating layer over said first structural polymer layer, planarizing the insulating layer, etching the first structural polymer layer through the insulating layer and the second metal layer to undercut the second metal layer, providing additional pre-formed structural polymer layers, at least one of which has been previously patterned, and finally bonding the additional structural layers in the form of a stack over the planarized second insulating layer to one or more microfluidic channels. The technique can also be used to make cross over channels in devices without electrostatic actuators, in which case the metal layers can be omitted.
    Type: Grant
    Filed: August 2, 2011
    Date of Patent: March 10, 2015
    Assignee: Teledyne DALSA Semiconductor, Inc.
    Inventors: Robert Johnstone, Stephane Martel
  • Patent number: 8974748
    Abstract: A dual inlet microchannel device and a method for using the device to perform a flow-through kinetic assay are described. A microplate having an array of the dual inlet microchannel devices and in particular their specially configured flow chambers is also described. Several embodiments of the dual inlet microchannel devices and specially configured flow chambers are also described.
    Type: Grant
    Filed: November 8, 2007
    Date of Patent: March 10, 2015
    Assignee: Corning Incorporated
    Inventors: Richard Bergman, Mark A. Lewis, Cheng-Chung Li, William J. Miller
  • Patent number: 8968683
    Abstract: The invention relates to a tissue sample handling apparatus, in particular for grasping histological samples after infiltration of an embedding medium such as, for example, paraffin, which is characterized in that a sample is immobilizable on the handling apparatus, in particular in a sample holding position, by means of negative pressure.
    Type: Grant
    Filed: April 20, 2012
    Date of Patent: March 3, 2015
    Assignee: Leica Biosystems Nussloch GmbH
    Inventors: Arne Burisch, Christian Löchte, Annika Raatz, Hermann Ulbrich, Karl-Heinrich Westerhoff
  • Patent number: 8969087
    Abstract: There is disclosed a method of pre-treatment and staining, according to a protocol, of a biological sample disposed upon the surface of a carrier, the method comprising the step of recording at least one parameter relating to at least one protocol step in a non-volatile memory located either upon or within the carrier or a device incorporating the carrier. Also disclosed is a device comprising: a non-volatile memory; a surface of the device adapted to carry a biological sample; and communications means electrically coupled to the memory for enabling data transmission to or from an external apparatus. Also disclosed is a method of controlling processing of a biological sample disposed upon a carrier, comprising: providing, upon or within the carrier or an apparatus holding the carrier, a non-volatile memory having information relating to sample processing priority or protocol; reading the information; and scheduling the processing based upon the information.
    Type: Grant
    Filed: September 6, 2012
    Date of Patent: March 3, 2015
    Assignee: Dako Denmark A/S
    Inventors: Loren L. Bland, Marc E. Key, Lars Winther, David A. Stanforth, Martin N. Lindberg
  • Publication number: 20150056695
    Abstract: This disclosure is directed to an apparatus and method for spreading a fluid across a substrate. A spreader for spreading a fluid across a substrate includes a wiper and a frame. The wiper and the frame may mate to permit translation of the wiper across, and with respect to, the frame. The wiper spreads the fluid across the substrate and the frame supports the wiper and the substrate. The frame may also include a ramp to cause a portion of the wiper to lift away from the substrate.
    Type: Application
    Filed: August 21, 2014
    Publication date: February 26, 2015
    Applicant: RareCyte, Inc.
    Inventors: Joshua Nordberg, Daniel Campton, Steve Quarre, David Stewart
  • Patent number: 8961901
    Abstract: A microfluidic system having a microchannel for the capillary transport of a liquid, in particular a body fluid for analytical purposes. The microchannel is provided with a surface coating comprising at least one hydrophilic substance selected from the group consisting of polyacrylic acid, polyacrylate, dextran sulfate and chondroitin sulfate. The invention also concerns a coating method that is suitable for this.
    Type: Grant
    Filed: July 26, 2007
    Date of Patent: February 24, 2015
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Michael Glauser, Hans-Peter Wahl, Irio Giuseppe Calasso, Emad Sarofim
  • Patent number: 8961903
    Abstract: A microfluidic passive device and a method for determining clotting time are described, of a fluid medium such as blood, of low production cost which can therefore be disposable. When optimised to determine blood clotting time, it requires a minimal whole blood sample (<5 ?L) and it is particularly suited to INR or PT determination, which can be used autonomously by patient without venipuncture. Monitoring, and processing means to interpret the results are comprised in an external coagulometer device. A production method for the manufacture of the microfluidic device is also provided.
    Type: Grant
    Filed: September 22, 2008
    Date of Patent: February 24, 2015
    Assignee: Iline Microsystems, S.L.
    Inventors: Iñaki Sádaba Champetier De Ribes, Juan Antonio Peón Eguiguren
  • Patent number: 8961899
    Abstract: The present invention provides integrated sample preparation systems and stabilized enzyme mixtures. In particular, the present invention provides microfluidic cards configured for processing a sample and generating DNA libraries that are suitable for use in sequencing methods (e.g., next generation sequencing methods) or other suitable nucleic acid analysis methods. The present invention also provides stabilized enzyme mixtures containing an enzyme (e.g., an enzyme used in whole genome amplification), BSA, and a sugar. Such enzyme mixtures may be lyophilized and stored at room temperature without significant loss of enzyme activity for months.
    Type: Grant
    Filed: June 24, 2013
    Date of Patent: February 24, 2015
    Assignee: IBIS Biosciences, Inc.
    Inventors: Mark Eshoo, John Picuri
  • Patent number: 8961898
    Abstract: The present invention provides a bilayer membrane produced using a microchannel capable of easily forming bilayer membranes such as planar lipid bilayer membranes in large quantities, and a production method thereof. A process for producing a bilayer membrane of the present invention comprises forming a state where two liquid phases or liquid and gaseous phases each containing amphipathic molecules are alternately arranged in a microchannel, discharging one of the two liquid phases or the gaseous phase of the liquid and gaseous phases through branch minichannels formed in the wall on one side or in the walls on both sides to contact the remaining liquid phases adjacent to each other, and thereby forming a side-by-side arrangement of bilayer membranes comprising the amphipathic molecules.
    Type: Grant
    Filed: March 28, 2008
    Date of Patent: February 24, 2015
    Assignee: Tokyo Institute of Technology
    Inventors: Takasi Nisisako, Takahiro Baba
  • Publication number: 20150047441
    Abstract: Described is a biological sample carrier based on a rigid hydrophilic object fabricated from a non-absorbing inert porous material. A biological fluid sample applied to the surface of the object is absorbed into the pores and constituents of the biological fluid sample remain in the pores after drying. Unlike a disc punched from a conventional dried blood spot (DBS) card, the object is easily handled. In contrast to DBS cards containing glass fiber structures that interact with basic analytes and other DBS card having adsorbing fibers that tend to separate blood constituents as the sample spreads through the fibers, the biological sample carrier is substantially inert to drug analytes.
    Type: Application
    Filed: March 4, 2013
    Publication date: February 19, 2015
    Inventors: Xin Zhang, Pamela C. Iraneta, Moon Chul Jung, Pamela J. Longenbach, Frank Marszalkowski, Jr.
  • Patent number: 8945486
    Abstract: A microwell device is provided. The device includes a plate having a upper surface. The upper surface has first and second recesses formed therein. Each recess has an outer periphery. First and second portions of microwells are formed in upper surface of the plate. The first portion of microwells are spaced about the outer periphery of the first recess and the second portion of microwells spaced about the outer periphery of the first recess. A first barrier is about a first portions of the microwells for fluidicly isolating the first portion of the microwells and a second barrier about a second portions of microwells for fluidicly isolating the second portion of the microwells.
    Type: Grant
    Filed: March 8, 2013
    Date of Patent: February 3, 2015
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Jay W. Warrick, John Yin, Stephen M. Lindsay
  • Kit
    Patent number: 8940248
    Abstract: A kit comprising a carrier and vessels arranged on the carrier, wherein different reagents are contained in different vessels, the vessels are arranged with an openable closing device on top of the carrier, the carrier has a footprint on the bottom side for being placed on a base, and the carrier has bottom positioning means for being positioned on at least one workplace of an automated laboratory system for microtiter plates according to the SBS standard.
    Type: Grant
    Filed: April 29, 2013
    Date of Patent: January 27, 2015
    Assignee: Eppendorf AG
    Inventors: Judith Lucke, Jens-Peter Kroog, Helmut Knofe
  • Patent number: 8940250
    Abstract: The present invention relates to a method of continuously conveying a liquid which is used as starting material in a chemical reaction by means of a displacement pump having physically separate forward-transport valves and a liquid-filled bidirectional flow line between displacement pump and forward-transport valves, wherein an auxiliary liquid which is a product or a starting material of the chemical reaction and has a melting point which is below the melting point or below the saturation temperature of the liquid to be conveyed is present in the bidirectional flow line. The present invention additionally provides for the use of a product formed by hydrogenation of an aromatic compound as auxiliary liquid for conveying an aromatic compound and also the use of an alcohol or an ester derived from alcohol and carboxylic acid as auxiliary liquid for conveying carboxylic acids or carboxylic acid derivatives.
    Type: Grant
    Filed: July 6, 2010
    Date of Patent: January 27, 2015
    Assignee: BASF SE
    Inventors: Joachim Pfeffinger, Willi Gilcher, Juergen Morell
  • Publication number: 20150021187
    Abstract: A device for passing a biopolymer molecule includes a nanochannel formed between a surface relief structure, a patterned layer forming sidewalls of the nanochannel and a sealing layer formed over the patterned layer to encapsulate the nanochannel. The surface relief structure includes a three-dimensionally rounded surface that reduces a channel dimension of the nanochannel at a portion of nanochannel and gradually increases the dimension along the nanochannel toward an opening position, which is configured to receive a biopolymer.
    Type: Application
    Filed: July 17, 2013
    Publication date: January 22, 2015
    Inventors: Qinghuang Lin, Gustavo A. Stolovitzky, Chao Wang, Deqiang Wang