Abstract: Provided herein are pipette tips having a proximal region with grooves and panels configured to facilitate wall expansion or wall compression when a pipette tip is mounted onto and sealingly engages with an appropriately designed liquid dispensing device.

Abstract: A pipette tip system is disclosed and includes a pipetter and a pipette tip. The pipetter has a suction lumen with an opening and an ejection bar that slides relative to the suction lumen. The pipette tip has a distal end with a distal end opening and a proximal end with a rim that defines a proximal opening adapted to receive the pipetter. The pipette tip also has a central lumen extending from the proximal end opening to the distal end opening and a pipette tip wall extending from the rim forming the central lumen. The pipette wall comprises a low-force stretch region with a plurality of thinning channels to allow for the stretching of the pipette tip wall.

Abstract: A collection device (10) which directs a flow of blood into a container (14) and provides a controlled blood flow path that ensures blood flow from a collection site to a collection container is disclosed.

Abstract: An adapter assembly for receiving a capillary includes a passage, into which the capillary is or can be received. The adapter assembly has an adapter cone which is configured for being received in or on a correspondingly configured counter cone. The adapter cone, at least over a section for bringing the adapter cone into contact with the counter cone, includes an elastic material that is more elastic than the material of the counter cone. The invention further relates to a counterpart for connecting to the adapter, to an apparatus and to a method for automatically exchanging capillaries.

Abstract: The present invention is directed to suppress adhesion of a reagent to the periphery of an opening of a reagent container. The reagent container is a reagent container used for a sample measuring apparatus having a suction tube for suctioning a reagent, and includes a reagent, an upper surface part having an opening, a side surface part, and a bottom surface part that defines an internal space in which the reagent is stored, and a suction tube introducing part extending from the upper surface part to a position above the liquid level of the reagent to introduce the suction tube received from above the opening into the internal space.

Abstract: Described herein are devices, systems, and methods to facilitate cryopreservation of a cell or a mass of a plurality of cells such as oocytes or embryos. A device of the disclosure can, for example, store oocytes or embryos during the vitrification and/or warming processes of in vitro fertilization.

Abstract: A system, apparatus, and method for transferring chemical solutions and synthesizing a tracer. For transferring chemical solutions, the system comprises a primary container; a secondary container; a first line in communication with the primary container and the secondary container. The first line facilitates the flow of gas and/or liquid between the primary container and the secondary container. A valve located upstream of the secondary container and downstream of the primary container regulates flow within the first line; a second line in communication with the secondary container. For synthesizing a tracer, the system includes a source of a solution having a radionuclide. A first container has a tracer precursor and is in communication with the source of solution.

Abstract: Pipette tip coupler and a disposable pipette tip for a pipette device comprises a stepped coupler shoulder complementary to an axially stepped pipette tip shoulder; a plurality of circumferentially disposed elements or segments carried by the coupler at a location superior to the coupler shoulder; and a distal elastomeric element carried by the coupler at a location distal to the coupler shoulder wherein the plurality of elements or segments have a circumferential, radially translated state that provides an abutment with a first working surface formed in the interior surface of the tip while compressing the distal elastomeric element into sealing abutment with a second working surface formed in the interior surface of the tip and while abutting the proximally facing axial stop surface of the tip with the distally facing axial stop surface of the coupler to define an axial coupling position of the pipette tip on the pipette device.

Abstract: A transport tool for transporting a laboratory article using a pipette of a pipetting system includes at least one plug-in sleeve, which is implemented for the releasable plugging-in of a receptacle cone of a pipette, and which can be plugged onto the receptacle cone of the pipette instead of a disposable pipette tip. In addition, the transport tool includes an article holder having at least one holding part, which is implemented to form a support connection with a laboratory article. A connecting part connects the article holder to the plug-in sleeve, so that holding axes of the article holder and the sleeve axis of the plug-in sleeve are arranged coaxially or axially-parallel to one another.

Abstract: A pipette for volumetrically metering powder includes an outer metering casing enclosing a metering chamber. The metering casing defines a free end of the pipette whereat the metering casing forms an opening. The metering chamber has an opposite end lying opposite to the free end of the pipette and the opposite end of the metering chamber is delimited by an air-permeable retaining element. The retaining element is configured as a flexible filter defining a plane and having a back side facing away from the metering chamber. An air-permeable support core supports the filter at the back side thereof and is rigid transversely to the plane of the filter.

Abstract: A method for producing a mini-vial of the type including a tubular container or vial, closed at a first end and open at its second end and capable of containing a product in fluid phase, a plunger sealingly movable in the vial through the second end and having an internal cavity capable of receiving the fluid from the vial, the plunger having a first end on which is placed a sealing cap and a second end movably slidable in the vial and at which is located a membrane filter, the plunger and vial being obtained by molding; the plunger being envisaged as overmolded onto the filter located at its second end, the membrane filter forming a single body with the plunger.

Abstract: The present invention provides a filter member. The filter member comprises: a filter for discriminating cells to be analyzed in a sample from other components; a first filter holding member which comprises a first through hole and has a plate-like shape; and a second filter holding member which comprises a second through hole and is fitted into the first filter holding member. When the first and second filter holding members are integrated by fitting the second filter holding member into the first filter holding member, the filter is sandwiched between the first filter holding member and the second filter holding member, and the first through hole is opposed to the second through hole through the filter. A first elastic body is formed on a surface of the first filter holding member, the surface being in contact with the filter. A second elastic body is formed on a surface of the second filter holding member, the surface being in contact with the filter.

Abstract: It has been difficult to conduct high-sensitivity, high-precision measurement due to externally generated contamination or cross-contamination. Thus, the invention includes (1) a filter unit having a filter at a bottom of a container for holding a liquid, the filter being adapted to filter a liquid, and (2) an attachment cover having a first opening and a second opening, the filter unit being attachable to and detachable from the attachment cover via the first opening, and the attachment cover being adapted to, when the filter unit is attached to the attachment cover, allow filtration by the filter in a state in which an inner face of the attachment cover is tightly in contact with an outer face of the filter unit, and discharge a resulting filtrate through the second opening.

Abstract: The invention relates to a carrier enclosing tip, a carrier treating apparatus, and a method of carrier treatment. An object is to perform separation/purification more efficiently and rapidly as compared with treatments using conventional liquid chromatography or filters. There is provided a carrier enclosing tip comprising: a tip-like container having a fitting opening which is fittable to a nozzle for use in gas suction and discharge, or a member to be fitted to a nozzle, and a port through which fluid inflow and outflow can be effected by the gas suction and discharge; and a carrier which is enclosed in the tip-like container, and is capable of adsorbing a biosubstance in the fluid or is capable of reacting with or binding to the biosubstance.

Abstract: A cartridge for dispensing fluid is presented. The cartridge comprises a valve. The valve comprises a pumping chamber for pumping the fluid. The valve positions a pumping chamber conduit. The pumping chamber conduit is connected to the pumping chamber. The cartridge further comprises a plunger for changing the volume of the pumping chamber. The cartridge further comprises a reservoir conduit for connecting the reservoir with the valve. The valve positions the pumping chamber conduit to connect with the reservoir conduit. The cartridge further comprises an outlet conduit for dispensing the fluid. The valve further rotates the pumping chamber conduit to connect with the outlet conduit.

Abstract: Disclosed herein is a device for sampling blood by capillarity for separating a plasma phase of the blood from the cell phase. The device is a strip and includes a filter having a membrane with no clumping agents, a prefilter for spreading blood over the surface of the membrane; and an absorbent paper downstream from the filter. The membrane is dimensioned to cover only a part of the surface of the prefilter and the migration of blood by capillarity within the prefilter takes place essentially lengthwise relative to the strip before blood comes into contact with the membrane.

Abstract: A sample input device for transferring liquid samples, typically blood samples, from sample containers, typically syringes, into analyzer devices for examining the composition of the samples, wherein the sample input device comprises retention elements for at least partly keeping particulate components of the sample from passing over from the sample container into the analyzer, and wherein the sample input device further contains at least one ventilation device that allows ventilating the sample container while transferring the sample from the sample container into the analyzer, typically when aspirating the sample via the analyzer.

Abstract: A production process of a poly(arylene sulfide) (PAS), including a polymerization step of forming a PAS from a sulfur source that is an alkali metal (hydro)sulfides and a dihalo-aromatic compound in an organic amide solvent; a separation step of PAS particles; a countercurrent washing step that is a step of washing the PAS particles with water and/or an organic solvent, wherein a downward current of a PAS particle-containing aqueous slurry is continuously brought into countercurrent contact with an upward current of a washing liquid; a PAS particle re-separation step of capturing a washing waste liquid by a PAS particle re-separating unit, in which a micro-slit filter has been installed, and then re-separating the PAS particles from the micro-slit filter, preferably using a backwashing unit, to discharge them; and a collecting step of the PAS particles discharged, and a production apparatus of a poly(arylene sulfide).

Abstract: A multi-well assembly including a filter plate and receiver plate. Each plate includes a plurality of wells, which, when the filter plate is placed in nesting relationship with the receiver plate, each filter plate well has a corresponding receiver plate well into which it extends. The receiver plate wells are of a non-uniform cross-section in order to increase the gap between the outer walls of the filter plate wells and the inner walls of a corresponding receiver plate well when the receiver plate and filter plate are in nesting relationship. The increased gap size reduces wicking and cross-contamination. A multi-section well of maximum cross-section in an upper region and a minimized cross-section in a lower region, with a gradual transition between the regions, is thus provided.

Abstract: The present invention provides sintered porous plastic plugs for use in filtered serological pipettes which facilitate manufacture or assembly of the filtered serological pipettes. In one embodiment, a sintered porous plastic plug of the present invention comprises plastic and a cylindrical body, a first end and a second end, the first end having a cross-sectional area less than the cross-sectional area of the cylindrical body, and the second end having a cross-sectional area less than the cross-sectional area of the cylindrical body.

Abstract: A filter vial and piston are provided where the vial has a cylindrical wall with a closed bottom and open top and with the hollow, tubular piston therein. The piston has a distal end covered by a cup having a proximal cup seal extending outward to engage the walls of the vial to form a fluid tight seal with the vial during use. The distal end of the piston has a piston flange extending outwardly and located adjacent a recess in the piston so the cup forms a snap fit over the piston flange and extends into the recess. The piston flange causes the cup to bulge sufficiently outward to form a fluid tight seal with the vial during use. A filter is placed in the bottom of the cup and abuts an inwardly extending lip on the cup. The filter is held against the lip by a piston support at the distal end of the piston. A cup support at a distal end of the cup also helps support the filter.

Abstract: Chromatography pipette tip having a first vessel and a second vessel which is open at two opposite ends and which, in each instance, has a bottom orifice via which a sample liquid can either be sucked in or expelled. The two vessels are fluidically and sealably connected to one another. A reaction matrix is arranged in one of the two vessels, through which reaction matrix the sample liquid is pushed by means of a pipettor to which the chromatography pipette tip is connected when used as intended. The sample liquid is drawn in and dispensed in opposite directions by the chromatography pipette tip and flows through the reaction matrix only in one direction.

Abstract: A suction tip includes a tip opening, a tubular passage provided with a first selector configured to permit the passage of non-selection subjects included in a collection of subjects sucked through the tip opening, and a capture portion provided on a side of the tubular passage downstream of the first selector in a suction direction of the collection of subjects and configured to capture the non-selection subjects. The capture portion includes a passage hole configured to permit the passage of the non-selection subjects and a storage portion configured to store the non-selection subjects having passed through.

Abstract: An improved upward flow constructed wetland cell for treatment of water contaminated with chlorinated aliphatics is disclosed. The improvements include adding ammonia-oxidizing microorganisms to the methane-oxidizing microorganisms already present in an oxygenated root zone and adding improved pore-water sample chambers for measuring the performance of the constructed wetland cell.

Abstract: Microsampling system for small amounts of fluid samples for analysis in the vapour phase, which comprises a plurality of integrated functional units and is suitable for small sample quantities with fast reaction times.

Abstract: A blood sampling transfer device that is adapted to receive a blood sample having a cellular portion and a plasma portion is disclosed. The blood sampling transfer device is able to separate the plasma portion from the cellular portion. After separation, the blood sampling transfer device is able to transfer the plasma portion of the blood sample to a point-of-care testing device. The blood sampling transfer device also provides a closed sampling and transfer system that reduces the exposure of a blood sample and provides fast mixing of a blood sample with a sample stabilizer. The blood sampling transfer device is engageable with a blood testing device for closed transfer of a portion of the plasma portion from the blood sampling transfer device to the blood testing device. The blood testing device is adapted to receive the plasma portion to analyze the blood sample and obtain test results.

Abstract: A biological fluid sampling transfer device adapted to receive a multi-component blood sample is disclosed. After collecting the blood sample, the biological fluid sampling transfer device is able to separate a plasma portion from a cellular portion. After separation, the biological fluid sampling transfer device is able to transfer the plasma portion of the blood sample to a point-of-care testing device. The biological fluid sampling transfer device also provides a closed sampling and transfer system that reduces the exposure of a blood sample and provides fast mixing of a blood sample with a sample stabilizer. The biological fluid sampling transfer device is engageable with a blood testing device for closed transfer of a portion of the plasma portion from the biological fluid sampling transfer device to the blood testing device. The blood testing device is adapted to receive the plasma portion to analyze the blood sample and obtain test results.

Abstract: A biological fluid sampling transfer device that is adapted to receive and separate a multi-component blood sample is disclosed. After separation, the biological fluid sampling transfer device is able to transfer a plasma portion of the blood sample to a point-of-care testing device. The biological fluid sampling transfer device of the present disclosure also provides a closed sampling and transfer system that reduces the exposure of a blood sample and provides fast mixing of a blood sample with an anticoagulant. The biological fluid sampling transfer device is engageable with a blood testing device for closed transfer of a portion of the plasma portion from the biological fluid sampling transfer device to the blood testing device. The blood testing device is adapted to receive the plasma portion to analyze the blood sample and obtain test results.

Abstract: A device for collecting, treating and dispensing a biological sample is described. Use of the device permits integration of sample collection, sample treatment, and sample dispensing.

Abstract: A biological processing system includes a platform assembly for holding slides and a dispenser assembly with dispensers. The dispensers are sequentially positionable over specimen-bearing slides to enable dispensing of substances onto specimens. The dispensers include a filter device for filtering a processing substance such that a substantially precipitate-free filtrate is applied to the specimens. The dispenser includes a filter device positioned at least partially in a reservoir chamber. The filter device includes anti-clogging features to maintain desired performance.

Abstract: The invention concerns an analyzer, typically for analyzing body fluids, which has one or several exchangeable cassettes (consumables) that contain operating liquids, operating materials and/or consumables and can be inserted into corresponding holders of the analyzer, wherein the analyzer has a system for exchanging ambient air which has a filter unit on the inlet side of the analyzer to filter the ambient air that needs to be exchanged. The filter unit is integrated into at least one of the exchangeable cassettes in order to minimize the amount of maintenance for the analyzer.

Abstract: A clinical diagnostic sample analyzer for analyzing a sample of a patient is disclosed. The analyzer includes a telescoping closed-tube sampling assembly with a sample probe concentrically housed within a piercing probe and a venting mechanism. The closed-tube sampling assembly is used for aspirating a sample from a sample tube for analysis by a clinical diagnostic sample analyzer.

Abstract: A device is provided by means of which biomolecules in samples in a volume range from <1 ?l to 500 ?l can be received, treated and stored in a quick, reproducible and loss-free manner as easily, effortlessly and practically as possible, and without any risk of damaging the device. The device includes sample vessels that are configured, in terms of size and shape, as dimensionally and positionally stable capillaries that are open at both ends, the longitudinal walls of which are completely or partially made of a semi-permeable membrane.

Abstract: Underdrain design for a multiwell device that when fixed to the device (either as an integral or removable component thereof), allows for adequate venting during filtration, minimizes or prevents air lock, and has improved structural integrity. Also disclosed is a laboratory device designed particularly for a multiplate format that includes a plate or tray having a plurality of wells, and an underdrain in fluid communication with each of the plurality of wells. The underdrain can be a separate, removable piece, or can be an integral unitary structure with the plate or tray forming a one-piece design. The design is preferably in compliance with SBS format.

Abstract: Filtration device suited for concentration of liquid samples, particularly biomolecules, and a method of concentrating, desalting, purifying and/or fractionating liquid samples. In certain embodiments the device includes a housing having a sample reservoir, and two substantially vertically oriented and spaced apart membranes disposed in the housing. An underdrain is associated with each membrane such that fluid passing through each membrane flows through a respective underdrain into a filtrate collection chamber. The fluid that does not pass through the membrane is collected in the retentate collection chamber, and can be recovered such as by a reverse spinning step, achieving recoveries greater than about 90%. The substantially vertical orientation of the membranes increases the available membrane area by at least 2.7 times the area available in a conventional filter device.

Abstract: A method filters particles from small volumes of fluid in a tubular vial having an open top and closed bottom with a tubular plunger sliding in the vial to force fluid through a filter at the end of the plunger and into a cavity in the plunger. The filter is held by a cap placed over the end of the plunger. The vial's bottom has an upward extending protrusion mating with a conforming recess in the cap to direct fluid to the protraction and filter as the cap abuts the bottom of the vial. Channels in the bottom help direct fluid flow.

Abstract: There is provided a sample liquid injection tool including a reservoir section configured to store a sample liquid, a channel having one end protruding from an outer surface and configured to discharge the sample liquid therein from a protrusion end to an outside, and a heating unit and a filter installed between the reservoir section and the channel to enable passage of the liquid.

Abstract: The present invention is a pipette tip device for extraction of liquid, semi-solid or solid solutions to be chemically analyzed and the methods for their use. The pipette tip extraction device contains a screen or filter at its lower narrow end to contain solid particulate matter and a barrier at its upper wide end. The optional upper frit is to be made of material that permits liquid solutions to flow through it. In addition to the barrier and screen, the pipette tip extraction device may contain solid-phase sorbent. Through the use of a removable cap, the pipette extraction tip may also serve as a sample collection container or tip in which samples can be delivered to the top of the tip (e.g., for direct collection of samples, including solid samples). A new method for DPX extraction using liquid-liquid-solid-phase extraction is also disclosed.

Abstract: An filter, apparatus and method for preparing microscope slides is presented. After filtration of the specimen is performed, the filter containing the filtrand is configured to be microscopically examined. The filter may either be affixed to a microscope slide or, in an embodiment, the filter may be incorporated into a microscope slide.

Abstract: A cap having a core structure dimensioned to receive a pipette therethrough. The cap includes two axially aligned frangible seals that are affixed to the core structure in a spaced-apart relationship. The frangible seals include a foil layer and are constructed so that air passageways are formed between the frangible seals and a pipette tip when the pipette tip penetrates the frangible seals. The cap optionally includes a filter interposed between the first and second frangible seals.

Abstract: A device adapted to determine an analyte concentration of a fluid sample using a test sensor. The device comprises a display adapted to display information to a user. The device further comprises at least one user-interface mechanism adapted to allow the user to interact with the device. The device further comprises a body portion including at least one opening formed therein, the at least one opening being of sufficient size to receive the test sensor. The device further comprises a memory adapted to store a plurality of stored analyte concentrations. The device further comprises a processing feature adapted to inhibit the stored analyte concentrations from being displayed on the display.

Abstract: A portable detection system for allergic diseases includes a filtration-based inspection module and a reader module. The filtration-based inspection module includes an FPW sensor and a liquid sample filtration apparatus, wherein the liquid sample filtration apparatus includes an injection opening, a passage module, a filtering membrane and a gathering aperture. The injection opening is in communication with the gathering aperture. The FPW sensor comprises a frame body, a carrier and a sensing chip having an accommodating slot in communication with the gathering aperture. The carrier comprises a plurality of conductive terminals, and the conductive terminals are electrically connected with the sensing chip. The reader module comprises a connection slot capable of being inserted by the conductive terminals of the carrier.

Abstract: Device for the synthesis of peptide-based radioactive drugs, for diagnostic and/or therapeutic use, includes: a frame; a closing case for the frame; a first disposable main module; a second disposable module, slidingly associated with the first module; a third disposable test-tube holder module, reversibly fixable to the frame (100) with fixing elements that allow the translation thereof with respect to the same. The first, second and third modules are arranged for irreversibly coupling so as to form one single disposable collector inside which the whole synthesis process of the concerned radioactive drug is performed, where at the end of the process, the collector may be removed from the device as one single contaminated mono block. The device is controlled by a remote control and drive workstation that includes a computer and devices for storing and managing data concerning the synthesis of the specific radioactive drug obtained for each treated patient.

Abstract: Microfluidic devices, assemblies, and systems are provided, as are methods of manipulating micro-sized samples of fluids. Microfluidic devices having a plurality of specialized processing features are also provided.

Abstract: In a general aspect, an apparatus for washing biological material is provided which includes an outer sleeve, and an inner sleeve disposed within the outer sleeve. The outer sleeve has an open end for receiving the biological material, and an opposed closed end. The inner sleeve is detachably and slidably positioned within the outer sleeve, and includes a first port for receiving and dispensing washing liquid, a second port defining a liquid flow path between an interior of the inner sleeve and an interior of the outer sleeve, and a filter disposed in the second port. The filter allows passage of washing liquid but not passage of the biological material therethrough. A chamber, formed between the filter and the closed end of the outer sleeve, is configured to permit flow of washing liquid via the filter while retaining the biological material therein.

Abstract: A disposable kit for use in directing fluid through a biological cell separator device (10). The kit generally includes a separator tube (22), a buffer fluid container (34), cell sample container (32), separated cell container (60), and flushing fluid container (62), as well as various conduits (36, 38, 42, 50, 50a, 50b) for connecting the containers (32, 34, 60, 62) and separator tube (22) in fluid communication together. A cell separator system is provided including a separator tube (22), magnet (20), pump (120) and a motorized drive unit (96). The motorized drive unit (96) is operatively connected to the magnet (20) to allow the magnet (20) to be moved a sufficient distance away from the separator tube (22) so as to allow cells adhered to the inside surface thereof to be flushed out of the tube (22).

Abstract: Sample processing methods and systems to collect and dilute a biological sample. A device collects a predetermined volume of sample in one chamber, seals the chamber upon activation, and mixes the sample with a predetermined volume of reagent.

Abstract: A device for continuously, periodically monitoring water for microbial germs, comprising a reactor and at least one reagent feed line into the reactor and at least one metering device for reagents as well as at least one measuring device for detecting the presence of microorganisms, wherein the reactor comprises a reactor chamber and a filtrate chamber, which is separated from said reactor chamber by means of a filter, a water feed line as well as a reagent feed line empty into the reactor chamber and at least one water discharge line leads out of the filtrate chamber, and a controller is set up to use pump/valve means to lead a predefinable quantity of water into the reactor chamber and through the filter as well as to introduce a predefinable quantity of reagent into the reactor chamber.

Abstract: A magnetic separation plate for use in methods employing magnetic particles, said magnetic separation plate comprising a support plate and magnetic pins in a predetermined geometrical arrangement, said magnetic pins having a fastening portion, an intermediate portion and a separation portion and being fastened to said support plate at their fastening portion, wherein said magnetic pins are individually displaceable at their separation portion. The invention further provides a method for the separation of magnetic particles using the separation plate.

Abstract: A cap having a core structure dimensioned to receive a pipette therethrough. The cap includes two axially aligned frangible seals that are affixed to the core structure in a spaced-apart relationship. The frangible seals are constructed so that air passageways are formed between the frangible seals and a pipette tip when the pipette tip penetrates the frangible seals. The cap optionally includes a filter interposed between the first and second frangible seals.