Stopper, Cover, Plug, Or Seal Patents (Class 422/568)
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Patent number: 11097277Abstract: A cover member for use in the treatment of a sample on a substrate is disclosed. The cover member has fluid flow features and is adapted for use in an instrument, such as a laboratory instrument. The cover member comprises at least one orientation feature detectable by the instrument for ascertaining an orientation of the cover member. An automated method for detecting orientation of a cover member in a sample treatment assembly is also disclosed, in which a processor compares data corresponding to one or more images collected from the sample treatment assembly, with data representing a reference image to determine if a cover member is in the sample treatment assembly.Type: GrantFiled: August 30, 2013Date of Patent: August 24, 2021Assignee: LEICA BIOSYSTEMS MELBOURNE PTY LTDInventors: Adam Michael Gray, Michael Stephen Glynn
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Patent number: 10222371Abstract: A qualitative detection system and method for visual verification of the presence of human protein in a biopsy specimen collection bottle is disclosed. The system comprises a lateral flow assay assembly securely contained within the lid of a biopsy specimen collection bottle or secured at the bottom of the bottle. The lateral flow assay assembly comprises components that amplify in color intensity through a chromogenic reaction in the presence of certain proteins. A change in color of the components of the lateral flow assay assembly acts as a visual index to qualitatively confirm the placement of human tissue in the biopsy specimen collection bottle.Type: GrantFiled: June 21, 2016Date of Patent: March 5, 2019Assignee: Nano 2.0 Business Press, LLCInventor: Steven M. Hacker
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Patent number: 9636679Abstract: The present invention relates to a cap comprising a body, an opening passing through the cap and adapted in turn to be passed through by at least one product transfer member, and a membrane which, at rest, covers the opening. The membrane has a main portion that extends through the opening and defines two inclined faces, each inclined face having a distal edge. The two inclined faces form a dihedron when the membrane is at rest, the distal edges of the two inclined faces coming together at the apex of the dihedron. The cap comprises at least two flaps that extend through the opening, above the membrane, the two inclined faces of the membrane being respectively covered by two flaps, each flap having a free edge that extends along the distal edge of the corresponding inclined face.Type: GrantFiled: December 20, 2011Date of Patent: May 2, 2017Assignee: BIO-RAD INNOVATIONSInventors: Laurent Fournier, Gilles Venturi
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Patent number: 9354245Abstract: A method which allows easy perforation of a film covering a well of a reagent cartridge which is set to a dispensing device is provided. A pipette tip set to be used in a dispensing device of an automatic analyzer together with a reagent cartridge in which a reagent for biochemical analysis is enclosed, includes: a dispensing pipette tip for dispensing the reagent enclosed in the reagent cartridge; a perforating pipette tip having a leading end surface inclined relative to a central axis thereof; and a rack configured to store the dispensing pipette tip and the perforating pipette tip together.Type: GrantFiled: May 16, 2014Date of Patent: May 31, 2016Assignee: TOPPAN PRINTING CO., LTD.Inventors: Tatsuya Ueki, Hiroyuki Kuroki, Eiji Kawata
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Patent number: 8962308Abstract: Systems and methods for processing and analyzing samples are disclosed. The system may process samples, such as biological fluids, using assay cartridges which can be processed at different processing locations. In some cases, the system can be used for PCR processing. The different processing locations may include a preparation location where samples can be prepared and an analysis location where samples can be analyzed. To assist with the preparation of samples, the system may also include a number of processing stations which may include processing lanes. During the analysis of samples, in some cases, thermal cycler modules and an appropriate optical detection system can be used to detect the presence or absence of certain nucleic acid sequences in the samples. The system can be used to accurately and rapidly process samples.Type: GrantFiled: January 23, 2013Date of Patent: February 24, 2015Assignee: Beckman Coulter, Inc.Inventors: Brian D. Wilson, Sami D. Alaruri, Matthew S. Davis, Matthew D. Erickson, Alan N. Johnson, Garrick A. Maurer, Mark F. Sauerburger, Daniel R. Schmidt, Joshua D. Wiltsie, Thomas M. Stachelek, David L. Yang
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Patent number: 8956580Abstract: An analysis cartridge comprising a cartridge body, a first cover, a liquid storage box and a sealing film is disclosed. The cartridge body has an accommodation portion and a first side and a second side opposite to the first side. The first cover covers the first side or the second side of the cartridge body and has a first through hole. The liquid storage box is disposed in the accommodation portion and has a liquid through hole. The sealing film seals the liquid through hole of the said liquid storage box and passes through the first through hole of the first cover, wherein the liquid through hole is exposed by removing the sealing film.Type: GrantFiled: January 14, 2013Date of Patent: February 17, 2015Assignee: Lite-On Technology CorporationInventors: Cheng-Chang Lai, Fu-Chun Huang, Yuh-Jiuan Lin
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Publication number: 20150031040Abstract: Method for the treatment of a biological sample comprising at least one cell and a liquid component; according to the method, a force is applied to the sample inserted in an inner chamber of a hollow device towards a filter which has pores with diameters from 2 nm to 1 ?m, so that at least part of the liquid component passes through the filter and the cell remains in the inner chamber, thus obtaining a concentrated sample; the filter has a surface facing the inner chamber of less than 12.6 mm2.Type: ApplicationFiled: December 28, 2012Publication date: January 29, 2015Applicant: SILICON BIOSYSTEMS S.P.A.Inventors: Alex Calanca, Gianni Medoro, Nicolò Manaresi, Giuseppe Giorgini
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Patent number: 8911680Abstract: The invention relates to a system for collecting a biological sample comprising a container having at least one open end, a closure fitting on or in said at least one open end, a holding element connected to said closure and a solid matrix on which said biological sample is deposited, and optionally at least one processing agent, wherein said solid matrix is at least partially transferable into a liquid or dissolved state by changing at least one physico-chemical property of the environment of said matrix without disintegration of the biomolecules comprised in said biological sample deposited on said matrix.Type: GrantFiled: December 27, 2007Date of Patent: December 16, 2014Assignee: Preanalytix GmbHInventors: Thomas Hanselle, Markus Sprenger-Haussels, Christian Lenz, Daniel Groelz, Uwe Oelmueller
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Patent number: 8883093Abstract: The invention relates to a piercable hermetic cover (2) for a bioassay cartridge (4) with at least one reaction chamber (6). Characteristic for the invention is that: the cover (2) comprises at least a top layer (8), a middle layer (10), a bottom layer (12), and sites intended for piercing (14); and the cover (2) has, at the sites (16) intended for piercing, a hollow space (18) between the top layer (14) and the bottom layer (12). The present invention also relates to a system (20) comprising a bioassay cartridge (4) and a cover (2) for the cartridge (4). The present invention further relates to use of the cover (2) for covering the cartridge (4).Type: GrantFiled: May 24, 2011Date of Patent: November 11, 2014Assignee: ArcDia International Oy LtdInventors: Janne Koskinen, Risto-Matti Ruonamo, Aleksi Soini
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Publication number: 20140322104Abstract: Adapter caps for sample collection containers have a monolithic elongate body with an upper neck portion that merges into a larger lower body portion with an open internal cavity. The upper neck portion has an open needle bore that is concentrically aligned with the open internal cavity. The monolithic elongate body has an axially extending centerline. The needle bore has a downwardly extending wall with an inner surface that comprises a plurality of circumferentially spaced apart longitudinally extending flat surfaces.Type: ApplicationFiled: April 23, 2014Publication date: October 30, 2014Applicant: bioMĂ©rieux, Inc.Inventors: Stanley M. Philipak, Samuel B. Crandall
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Patent number: 8871160Abstract: Provided is a biomaterial detecting device for confirming or detecting a biomaterial reaction, and more particularly to a biomaterial detecting device, which is formed in a stick type to thereby be immersed in a tube containing a biomaterial solution to be tested; has an upper portion with a cap structure to thereby induce reaction with a biomaterial, and thus facilitate confirmation and detection of the biomaterial; and is formed in a cap structure to thereby prevent evaporation of a sample and infiltration of an external material at the time of a biomaterial reaction in the tube, and thus improve reliability in analysis.Type: GrantFiled: July 20, 2012Date of Patent: October 28, 2014Assignee: K-MACInventors: Sung-Min Seo, Jae-Hyung Park, Oleksandrov Sergiy, Joong Hwan Lee, Mun-Cheol Paek, Su-Jin Ku
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Publication number: 20140315256Abstract: A cover member for a substrate supporting a biological sample comprises first and second opposing ends, first and second opposing surfaces, a void in the second surface which, when juxtaposed with a substrate, forms a chamber, and a fluid inlet toward the first end and in fluid communication with the void. The void is bounded by void walls having one or more contoured regions for enhancing fluid movement within the chamber. A treatment module for a biological sample comprises the cover member, a support surface for a substrate bearing the biological sample and clamp means operable to releasably retain the cover member in juxtaposition with the substrate for an incubation period. A method for incubating the biological sample with one or more reagents uses the cover member.Type: ApplicationFiled: November 15, 2012Publication date: October 23, 2014Applicant: LEICA BIOSYSTEMS MELBOURNE PTY LTDInventors: Mark Brian Dockrill, Anthony Favaloro, Kenneth Heng-Chong Ng, Martin Limon, Peter Toogood, Stephen John Bagnato
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Publication number: 20140260118Abstract: System, apparatuses, and methods for performing automated reagent-based analysis are provided. Also provided are methods for automated attachment of a cap to a reaction receptacle, and automated removal of a cap from a capped reaction receptacle.Type: ApplicationFiled: March 13, 2014Publication date: September 18, 2014Inventor: Byron J. KNIGHT
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Publication number: 20140256058Abstract: The present invention discloses a lid for a sample tube and a sample tube enabling ventilation or sealing depending on the closing position of the lid. Furthermore, a method for drying a sample and a use of the above lid or of the above sample tube for storing or drying a sample are subjects of the present invention.Type: ApplicationFiled: October 2, 2012Publication date: September 11, 2014Inventor: Peter Dobrowolski
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Patent number: 8815181Abstract: A delivery apparatus for selectively delivering one or more liquid reagents into a reaction or test chamber (2), especially of an assay apparatus, the apparatus comprising: one or more respective storage chambers (5,6) for containing the one or more liquid reagents and arranged generally above the reaction or test chamber (2); and a plunger element (4) arranged and operable for insertion into the mouth of a selected storage chamber so as to displace a selected reagent from therewithin into the reaction or test chamber (2) generally therebelow by gravitational liquid overflow from the mouth of the chamber. The apparatus may conveniently be provided as a discrete delivery unit, with the storage chambers (5,6) pretilled with the selected reagents.Type: GrantFiled: October 23, 2012Date of Patent: August 26, 2014Assignee: The Secretary of State for Defence in Her Britannic Majesty's Government of the United Kingdom of Great Britain and Northern IrelandInventor: David James Squirrell
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Patent number: 8795608Abstract: A controlled release and self-resealing vessel assembly for high pressure, microwave assisted chemistry is disclosed. The vessel assembly includes a cylindrical reaction vessel formed of a material that is substantially transparent to microwave radiation. The vessel has angular walls, one closed end for retaining reactants in the lower portions of the vessel, and one open end that defines a mouth for the vessel. The mouth of the cylinder vessel has a lip that is beveled inwardly from the open end. A microwave-transparent solid floating plug closes the mouth of the reaction vessel; with the plug have a frustum portion for engaging the beveled lip when the plug is placed in the mouth of the vessel. A lid exerts a defined axial force against the plug for sealing the plug in the open end of the cylinder with the frustum engaging the lip.Type: GrantFiled: August 8, 2011Date of Patent: August 5, 2014Assignee: CEM CorporationInventor: Wyatt Price Hargett, Jr.
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Patent number: 8790599Abstract: A system for analyzing, manipulating, and recording data associated with a microtiter plate is provided. The system provides a touch screen element provided proximal to the microtiter plate such that data pertaining to events and conditions observed within one or more wells of the microtiter plate may be easily and accurately recorded. Data display, storage, and manipulation features are also provided.Type: GrantFiled: August 13, 2012Date of Patent: July 29, 2014Inventors: David Childs, Michael Sharer
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Patent number: 8784753Abstract: A thermal cycling instrument for PCR and other reactions performed on multiple samples with temperature changes between sequential stages in the reaction procedure is supplied with a thermal block to provide rapid changes and close control over the temperature in each sample vessel and a pressure plate incorporated into a motorized lid that detects anomalies in the reaction vessels or in their positioning over the thermal block, and automatically adjusts the plate position to achieve an even force distribution over the sample vessels.Type: GrantFiled: July 17, 2012Date of Patent: July 22, 2014Assignee: Bio-Rad Laboratories, Inc.Inventors: Jeffry M. Ceremony, Daniel Y. Chu, Deepak K. Doshi, Rhoel Rumbaoa, Dennis W. Loring, Paul J. Patt, Cliff Baldwin
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Patent number: 8784752Abstract: Methods and devices for adding liquids to and washing a microfluidic element array are disclosed. The method and devices feature a microfluidic plate holder with a sloped wall for improved draining of liquid, a machine readable/writable identifier, plate leveling systems, liquid filling systems, a hydrophilic-liquid coating, and an automated washing station.Type: GrantFiled: April 16, 2010Date of Patent: July 22, 2014Assignee: Curiox Biosystems Pte LtdInventors: Namyong Kim, Kong Leong Cheng, Li Li, Teow Soon Seah
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Patent number: 8778283Abstract: A delivery apparatus for selectively delivering one or more liquid reagents into a reaction or test chamber (2), especially of an assay apparatus, the apparatus comprising: one or more respective storage chambers (5,6) for containing the one or more liquid reagents and arranged generally above the reaction or test chamber (2); and a plunger element (4) arranged and operable for insertion into the mouth of a selected storage chamber so as to displace a selected reagent from therewithin into the reaction or test chamber (2) generally therebelow by gravitational liquid overflow from the mouth of the chamber. The apparatus may conveniently be provided as a discrete delivery unit, with the storage chambers (5,6) prefilled with the selected reagents.Type: GrantFiled: January 25, 2010Date of Patent: July 15, 2014Assignee: The Secretary of State for DefenceInventor: David James Squirrell
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Patent number: 8728414Abstract: A closure for a container has a closure body having a first cylindrical portion and a second cylindrical portion opposite the first portion. The closure also has a connector disposed in at least one of the first and second portions. The connector is adapted to connect one of a sample collection device and an applicator to the closure. A containing apparatus including the closure, a container, and optionally one of a sample collection device and an applicator is also disclosed. A method of using the containing apparatus is also disclosed.Type: GrantFiled: May 14, 2010Date of Patent: May 20, 2014Assignee: DNA Genotek Inc.Inventors: Michael Beach, Roy Sunstrum, Maurice Lavimodiere, Adele Jackson, Rafal Michal Iwasiow, Ellen Maclean, H. Chaim Birnboim
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Patent number: 8696778Abstract: A self-contained breathing closure for flasks and other containers that require gas exchange. An illustrative embodiment of the closure is comprised of a splashguard, an adaptor for attaching the closure to the container, a bellows element and a gas-permeable barrier element. The splashguard is intended to keep liquid contents under vigorous agitation in the container without wetting the gas-permeable barrier. The adaptor couples the closure to the container in a secure fashion. The bellows element allows for repeated changes in the internal volume of the container-closure system. The gas-permeable barrier allows desired gases to enter and leave the container while excluding small particles and/or microorganisms. The technology may be used with existing glass flask technology, or coupled to a plastic flask that may be configured for either single-use, or multiple-use.Type: GrantFiled: November 5, 2010Date of Patent: April 15, 2014Inventors: Todd A. McAdams, Harold W. Howe, Jeffrey E. Draper, Lawrence C. Farrar
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Patent number: 8685345Abstract: An insert for a sample chamber of a multi-well plate, which delimits the sample chamber upwardly, so as to form a measurement space, when the insert is in the state in which it is fitted into the sample chamber. The insert has at least two portions with outer contours differing from one another, one of the portions being a sealing portion with a continuous sealing surface, which sealing portion is adapted to a corresponding, in particular hollow-cylindrical sealing portion, with a likewise continuous sealing surface, of the sample chamber, in such a way that the insert sealing portion and the sample chamber sealing portion can be connected to one another releasably and in a liquid-tight manner by means of a press fit.Type: GrantFiled: August 20, 2012Date of Patent: April 1, 2014Assignee: Erwin Quarder Systemtechnik GmbHInventor: Eike Kottkamp
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Patent number: 8685347Abstract: A cap having a core structure dimensioned to receive a pipette therethrough. The cap includes two axially aligned frangible seals that are affixed to the core structure in a spaced-apart relationship. The frangible seals include a foil layer and are constructed so that air passageways are formed between the frangible seals and a pipette tip when the pipette tip penetrates the frangible seals. The cap optionally includes a filter interposed between the first and second frangible seals.Type: GrantFiled: November 15, 2011Date of Patent: April 1, 2014Assignee: Gen-Probe IncorporatedInventors: Daniel L. Kacian, Mark R. Kennedy, Nick M. Carter
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Patent number: 8632740Abstract: A collection device and a method for collecting a biological sample, particularly whole blood, includes a separating member to separate the whole blood into its components, and at least reagent positioned to selectively interact with a component of the separated sample. The reagent is able to selectively interact with the plasma/serum, and is prevented from contacting or interacting with the whole blood.Type: GrantFiled: May 4, 2010Date of Patent: January 21, 2014Assignee: Becton, Dickinson and CompanyInventors: Ajit Dastane, Dimitrios Manoussakis, Christopher Battles, Paul Dicesare, Jeffrey Radziunas
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Publication number: 20140010740Abstract: Device (1a, 1b, 1c, 1d; 40) for extracting, storing and/or processing blood or other substances of human or animal origin, and for applying blood compounds or other biological compounds, which comprises a body (2; 41) inside which a piston (3; 42) is capable of moving longitudinally and is separable at least in part, where the body (2; 41) is provided with an internal space (9; 51) that may be connected to the outside by means of a conduit (6; 50) at a first end (4; 48) of the body (2; 41), where the body (2; 41) and the piston (3; 43) may be blocked longitudinally in at least one position to allow the creation of different degrees of vacuum. The device has multiple uses and is extremely versatile.Type: ApplicationFiled: July 3, 2013Publication date: January 9, 2014Inventor: Eduardo ANITUA ALDECOA
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Publication number: 20130337432Abstract: In particular, a disposable cartridge is disclosed that is suitable for use with a clinical or diagnostic point-of-care device and capable of performing diagnostic and analytical functions including filtering samples such as plasma from whole blood and running assays and collecting measurements of analytes or biomarkers.Type: ApplicationFiled: March 15, 2013Publication date: December 19, 2013Applicant: WELLSTAT DIAGNOSTICS, LLCInventor: Wellstat Diagnostics, LLC
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Publication number: 20130334118Abstract: A method of manufacturing a sealing fluidic component based on a capillary enclosing a fluid conduit and having an exterior surface being at least partially coated with a coating of a meltable material, wherein the method comprises melting the meltable material of the coating at least at an end portion of the capillary, and resolidifying the melted material to thereby form, at the end portion, a sealing integral with the coating and constituted at least partially by the meltable material.Type: ApplicationFiled: August 30, 2013Publication date: December 19, 2013Inventor: Thomas Reinhardt
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Patent number: 8609044Abstract: A micro vial assembly for performing microwave-assisted chemical reactions on small reaction mixture volumes is disclosed, wherein a reaction vessel (10) is sealed through a diaphragm (30) that is capped over an open end of the reaction vessel. The reaction vessel mouths in an end plane of a sleeve (20) surrounding the reaction vessel, the diaphragm being clamped for sealing the open end of the vessel by means of a cap (40) which is secured to the sleeve. The sleeve provides a radial extension of the reaction vessel in order to bridge the radial distance between a wall of the reaction vessel and other components in a system for performing microwave-assisted chemical reactions.Type: GrantFiled: December 18, 2003Date of Patent: December 17, 2013Assignee: Biotage ABInventors: Johan Ulin, Per-Gunnar Eriksson, Fredrik Ekdahl
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Publication number: 20130318915Abstract: An automatic test tube recapper is presented that is capable of recapping thousands of test tubes per day. Specially designed caps are poured into an upper triangular shaped hopper. The randomly oriented caps are transported by a pair of belts to an upper slide. Misaligned caps are rejected and fall back into the hopper, while properly aligned caps slide down the slide to a cap catch, one at a time. A hammer shaft then drives the cap into the top of the test tube until the cap is firmly seated. The hammer shaft reverses, which withdraws the shaft upwards. As the hammer shaft moves upwards, it triggers a pair of arms that allows another cap to fall into the cap catch. A conveyor also automatically moves the next uncapped test tube under the cap. The cycle then repeats itself.Type: ApplicationFiled: June 1, 2012Publication date: December 5, 2013Inventors: REDA R. ISKAROUS, James I. Wonders
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Publication number: 20130302842Abstract: A microfluidic device and method is provided for handheld diagnostics and assays. A first substance is frozen in a cryopreservation fluid in a first well of a lid. The lid includes a first surface communicating with a first port of the first well and a second surface communicating with a second port of the first well. A porous membrane is affixed to the first surface so as to overlap the first port and a non-porous membrane is affixed to the second surface so as to overlap the second port. The first substance may be dialytically freed from the cryopreservation fluid at a user desired time. Thereafter, the lid may be moved from a first position wherein the lid is spaced from a base to a second position wherein the lid is adjacent the channel in the base such that the first substance communicates with the input of the channel.Type: ApplicationFiled: May 9, 2012Publication date: November 14, 2013Inventors: Erwin Berthier, Peter Cavner, David John Guckenberger, David Beebe
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Patent number: 8528777Abstract: A reaction tube for use in performing the Polymerase Chain Reaction (PCR) in a thermal cycler, is provided herein such reaction tube includes a hollow tube of heat conducting synthetic plastics material having an open top and a flat bottom formed of an optically-clear material. Such reaction tube also includes a solid plug cap nesting within said hollow tube and to provide a minimized void volume within the hollow tube and to minimize evaporation and condensation of the biological fluid.Type: GrantFiled: April 4, 2010Date of Patent: September 10, 2013Assignee: Spartan Bioscience Inc.Inventors: Chris Harder, Martin Cloake, Michel Perreault, Paul Lem, Alan Shayanpour
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Publication number: 20130224868Abstract: A closure is described for a container containing a reagent. The closure includes a cover. The cover includes at least two through bore holes. The closure further includes a strip which includes a base and at least two septa. The base is of a stiff material and the septa is of a flexible material. The septa are attached to one surface of the base. Each septum includes a pre-slit bottom and a barrel forming the sides of the septum. The outer diameter of each septum barrel is larger than the inner diameter of the through bore hole such that a pressure is exerted on the septum when the septum is press fitted into the through bore hole.Type: ApplicationFiled: February 22, 2013Publication date: August 29, 2013Applicant: Roche Molecular Systems, Inc.Inventor: Roche Molecular Systems, Inc.
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Patent number: 8491854Abstract: A test tube insert includes a flange having a width greater than a width of a mouth of a larger test tube into which the insert is to be inserted. The flange defines a first central opening. An annulus extends integrally downward from the flange. The annulus includes a fenestrated wall and a floor defining a second central opening. A small test tube body, smaller than the larger test tube, extends integrally downward from the floor of the annulus with the second central opening forming a mouth of the small test tube body. The test tube insert is disposed in the mouth of the larger test tube. Fluid is transferred through the central opening and the fluid fills the small test tube body of the test tube insert and flows through the fenestrated wall once the small test tube body is full into the larger test tube.Type: GrantFiled: November 8, 2010Date of Patent: July 23, 2013Assignee: King Saud UniversityInventor: Abdullah Khalid Al-Rasheed
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Patent number: 8491841Abstract: An analytical combustion furnace has an input port for receiving a holder for an analytical sample. A purge block is coupled to the input port of the combustion furnace and has an input end for receiving the holder and a gas inlet and a gas outlet. A door selectively closes the input end of the purge block, and a pressurized seal is coupled between the purge block and the door. A source of purging gas is coupled to the gas inlet of the purge block for pressurizing the seal. The gas outlet of the purge block communicates with the seal to allow purging gas to escape the area of the seal. In one embodiment, a pressurized seal surrounds a push rod, which seal is pressurized by a purging gas to continuously purge the entry of the push rod into the purge block, thereby eliminating atmospheric contamination.Type: GrantFiled: August 10, 2010Date of Patent: July 23, 2013Assignee: Leco CorporationInventors: Kim A. Marshall, Steven J. Rohaly, Carl Warren
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Publication number: 20130078734Abstract: A cover for a substrate including: a body defining a cavity, for positioning over the substrate to form a reaction chamber; and a projection extending from the body to define a fluid reservoir, when the cover is fitted to the substrate, the fluid reservoir being in fluid communication with the cavity.Type: ApplicationFiled: November 21, 2012Publication date: March 28, 2013Applicant: LEICA BIOSYSTEMS MELBOURNE PTY LTDInventor: Leica Biosystems Melbourne PTY Ltd
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Publication number: 20130058845Abstract: A vial and closure assembly including a vial and a closure configured to be threadably coupled to the vial. The vial has an opening end that is defined by a vial rim and at least one thread located proximate to the open end of the vial. The closure includes a top wall with a skirt wall depending from the top wall. A septum pocket is provided in the top wall and is configured to receive a septum positioned therein. A protrusion depends from the top wall, extends into the septum pocket, and is configured to engage the septum so that the septum creates an essentially vapor-tight seal with the vial rim when the closure is threadably coupled to the vial.Type: ApplicationFiled: July 31, 2012Publication date: March 7, 2013Applicant: NATIONAL SCIENTIFIC COMPANYInventor: Leemen Loy Shick
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Publication number: 20130052102Abstract: An insert for a sample chamber of a multi-well plate, which delimits the sample chamber upwardly, so as to form a measurement space, when the insert is in the state in which it is fitted into the sample chamber. The insert has at least two portions with outer contours differing from one another, one of the portions being a sealing portion with a continuous sealing surface, which sealing portion is adapted to a corresponding, in particular hollow-cylindrical sealing portion, with a likewise continuous sealing surface, of the sample chamber, in such a way that the insert sealing portion and the sample chamber sealing portion can be connected to one another releasably and in a liquid-tight manner by means of a press fit.Type: ApplicationFiled: August 20, 2012Publication date: February 28, 2013Applicant: ERWIN QUARDER SYSTEMTECHNIK GMBHInventor: Eike Kottkamp
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Patent number: 8372338Abstract: The apparatus and method for sterilising caps/stoppers for pharmaceutical purposes comprises a vessel, pump, heater, circulation line. The sterilising liquid (hot water, steam) is heated and pumped to the vessel where a fluidised bed of caps etc. is generated. After leaving the vessel the liquid is circulated/heated. Optionally an additive (siliconisation in case rubber parts) or cooling liquid is added. Further, the vessel is disconnectably attached to the supply lines for transportation to a production facility.Type: GrantFiled: August 11, 2007Date of Patent: February 12, 2013Assignee: Getinge Sterilization ABInventor: Lars Joakim Larsson
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Patent number: 8354080Abstract: An interface cartridge for a microfluidic chip, with microfluidic process channels and fluidic connection holes at opposed ends of the process channels, provides ancillary fluid structure, including fluid flow channels and input and/or waste wells, which mix and/or convey reaction fluids to the fluidic connection holes and into the process channels of the microfluidic chip.Type: GrantFiled: April 12, 2010Date of Patent: January 15, 2013Assignee: Canon U.S. Life Sciences, Inc.Inventors: Ray Tsao, Hiroshi Inoue, Shulin Zeng, Brian Murphy, Kenton C. Hasson
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Patent number: 8327725Abstract: There is provided a sample collection container, a sample collection apparatus, and a sample collection method used in a supercritical fluid system capable of collecting a multi-constituent sample contained in a supercritical fluid at low cost and high collection efficiency. The pressure of a supercritical fluid containing a sample is reduced to a pressure close to the atmospheric pressure, and the depressurized supercritical fluid is forced to undergo adiabatic expansion to form gas-phase CO2 containing a liquid component in the form of aerosol. The gas-phase CO2 is fractionated for each constituent of the contained sample, transferred to a probe 60 of Liquid Handler, and dispensed into a large number of collection vials 300 under the atmospheric pressure, each of which is provided with a vial cap 100.Type: GrantFiled: September 26, 2009Date of Patent: December 11, 2012Assignee: JASCO CorporationInventor: Takeshi Kanomata
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Publication number: 20120295343Abstract: A closure assembly for a cell culture apparatus includes a port and a snap cap. The port has an annular sidewall defining an opening in communication with a cell culture chamber of a cell culture apparatus. The sidewall has (i) external threads for cooperating with internal threads of a twist cap and (ii) an annularly protruding snap cap engagement feature. The snap cap has a top and an annular sidewall extending from the top. The sidewall of the snap cap has an inwardly annularly projecting element configured to engage with the annularly protruding snap cap engagement feature of the port such that, when fully engaged, the snap cap is not readily removed from the port by unaided human force.Type: ApplicationFiled: November 17, 2011Publication date: November 22, 2012Inventors: Adam J. Bear, Heidi M. Brown, Matthew D. Mitchell, James Philippe, Paul Kevin Seeto
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Publication number: 20120270308Abstract: The invention relates to a pressing arrangement for a cover, in particular in a laboratory thermostat, having at least: a first component disposed to exert an excitation force, a second component, in particular a plate component disposed to exert a pressing force Fz in at least one target position, a transmission device disposed for transmitting force from the first component to the second component, characterized in that the transmission device comprises a transmission component disposed to be driven by the first component and to drive the second component, and the transmission device comprises at least one elastic tensioning member disposed to be driven by the first component so as to change its tension and to drive the transmission component, and the transmission device or the transmission component causes the setting of the pressing force Fz in dependence on the target position. The invention further relates to a corresponding method for pressuring.Type: ApplicationFiled: February 21, 2012Publication date: October 25, 2012Applicant: Eppendorf AGInventors: Gregor Bechmann, Lutz Timmann, Manuel Petzold, Stefan Roth, Arne Schafrinski
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Patent number: 8287821Abstract: A sample storage, in which barcodes and two-dimensional codes written on the outer surface of the sample storage can be read correctly without false recognition. A storage tube 110 is made of transparent material, comprising a top opening. An externally equipped opaque writable element 120 is assembled outside by covering storage tube 110 throughout from the bottom surface to the side surface. An externally equipped opaque writable element 120 is to be used as a medium to which coded information that can be read by means of optical reading is written. The top opening of the storage container 110 is sealed by the lid element screwed into or fitted into the externally equipped opaque writable element 120 not to the storage container 110. At least one window 125 is provided, which enables a sample 200 contained to be observed, with the externally equipped opaque writable element 120 assembled outside.Type: GrantFiled: March 11, 2009Date of Patent: October 16, 2012Inventors: Yoko Nakahana, Shinichiro Kakuda
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Patent number: 8273312Abstract: A liquid testing assembly for testing a liquid, the assembly comprising a test vessel and a stopper adapted to fit into a free end of the vessel. The stopper substantially hermetically seals the test vessel from the ambient. Further, the assembly includes a support coated with one or more identifying materials for identifying one or more constituents of the liquid. The support is fixed in the stopper and/or the vessel and extends into its interior for a predetermined distance. The liquid testing assembly when assembled is pre-evacuated to a predetermined vacuum sufficient to draw a predetermined volume of liquid to be sampled into the test vessel. The predetermined volume is of such an amount that it wets the one or more identifying materials ensuring identification of one or more constituents present in the liquid. A kit employing the liquid testing assembly is also discussed.Type: GrantFiled: January 22, 2008Date of Patent: September 25, 2012Assignee: Association for Public HealthInventors: Gadi Porat, Joel Stern, Boaz Rimon, Yoram Cohen
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Publication number: 20120219470Abstract: The present invention provides the use of a composition comprising a block polymer as a support matrix in the manipulation, processing or analysis of particles, such as cells and fluorescent beads. In a preferred embodiment, the composition exhibits gel-sol thermoreversibility, micelle formation under gelling conditions, optically compatible, controllable surfactant properties, molecular sieving properties and biocompatibility. Further aspects of the invention provide (a) a support matrix composition comprising a block polymer, fluorescent beads and/or a dye for use in the manipulation, processing or analysis of particles, (b) a multichamber plate coated in a support matrix composition and (c) kits for producing the same.Type: ApplicationFiled: March 29, 2010Publication date: August 30, 2012Inventors: Paul Smith, Laurence Patterson, Rachel Jane Errington
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Patent number: 8252603Abstract: Fluid containers are disclosed which have fluid reservoirs in their closures. These reservoirs are advantageous to hold sacrificial fluid which lessens the loss of the fluid of interest to the outside through evaporation. The reservoirs may have openings to the inside or outside of the container, or to both. Reservoirs with openings to the outside serve to reduce evaporative loss by raising the partial pressure of fluid in the vicinity of the contact between the closure and the remainder of the container. The reservoirs may be refillable without opening the container. In one embodiment a fluid reservoir allows the zone of contact between the closure and the remainder of the container to be immersed in fluid, so that gases seeking to escape the interior of the container must pass through fluid.Type: GrantFiled: November 11, 2010Date of Patent: August 28, 2012Assignee: Labcyte Inc.Inventors: Richard N. Ellson, Michael F. Miller, Arlen Mark Bramwell
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Patent number: 8216853Abstract: An apparatus and method for sealing a fluid sample collection device, comprising: loading a fluid sample collection device with a fluid sample, said device comprising a housing having at least one substantially planar surface that includes an orifice in fluid communication with an internal fluid sample holding chamber which terminates at an internal capillary stop; and slidably moving a sealing element over at least a portion of said substantially planar surface in a way that displaces any excess fluid sample away from the orifice, seals the fluid sample within said holding chamber, and inhibits the fluid sample from prematurely breaking through the internal capillary stop.Type: GrantFiled: July 13, 2011Date of Patent: July 10, 2012Assignee: Abbott Point of Care Inc.Inventors: Cary James Miller, Andy Maczuszenko
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Publication number: 20120141340Abstract: Liquid receptacle with an opening for receiving liquid dispensed at a distance there above, wherein the receptacle comprises a liquid receiving member arranged in the vicinity of the opening and at an angle with respect to the motion of dispensed liquid to receive and direct dispensed liquid into the receptacle.Type: ApplicationFiled: August 24, 2010Publication date: June 7, 2012Applicant: GE HEALTHCARE BIO-SCIENCES ABInventors: Lars Rosengren, Johan Svensson, Tomas Agren, Mathias Osmark, Per Stromberg
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Patent number: RE45194Abstract: A cap having a core structure dimensioned to receive a pipette therethrough. The cap includes two axially aligned frangible seals that are affixed to the core structure in a spaced-apart relationship. The frangible seals are constructed so that air passageways are formed between the frangible seals and a pipette tip when the pipette tip penetrates the frangible seals. The cap optionally includes a filter interposed between the first and second frangible seals.Type: GrantFiled: November 8, 2013Date of Patent: October 14, 2014Assignee: Gen-Probe IncorporatedInventors: Daniel L. Kacian, Mark R. Kennedy, Nick M. Carter