Means Is Turntable (circular) Patents (Class 422/64)
  • Patent number: 10350601
    Abstract: A system for isolating cells in at least one of single-cell format and single-cluster format, comprising a reservoir, including a reservoir inlet and a reservoir outlet, configured to receive a biological sample and to receive at least one fluid, a manifold configured to receive and deliver the biological sample and the at least one fluid from the reservoir into a biological sample substrate, the manifold comprising a broad surface comprising a central region configured to receive the biological sample substrate, a set of openings configured to enable fluid flow transmission across the biological sample substrate, a manifold inlet configured to transmit flow from the reservoir the first subset of openings, a manifold outlet configured at a downstream end of the broad surface and coupled to the second subset of openings, the manifold outlet configured to transmit waste fluid from the manifold.
    Type: Grant
    Filed: October 12, 2017
    Date of Patent: July 16, 2019
    Assignee: Celsee Diagnostics, Inc.
    Inventors: Kalyan Handique, Kyle Gleason, Austin Payne, Priyadarshini Gogoi, Christopher Siemer, Yi Zhou, Saedeh Javdani Sepehri
  • Patent number: 10281376
    Abstract: An apparatus for spreading at least one reagent on at least a portion of a microscope slide includes a spreading device positionable in association with a microscope slide in a way that the spreading device defines a gap between the spreading device and the microscope slide and in a way that the spreading device and the microscope slide are movable relative to one another to spread at least one reagent on at least a portion of the microscope. The spreading device has a reservoir in which the at least one reagent is stored in a way that the at least one reagent is dischargeable from the reservoir onto the microscope slide when the spreading device is positioned in association with the microscope slide.
    Type: Grant
    Filed: August 13, 2018
    Date of Patent: May 7, 2019
    Inventor: Lee H. Angros
  • Patent number: 10190089
    Abstract: A modular automated system for sample processing and/or detection of microorganisms is provided. The modular system includes modules that perform at least one function in the process of detecting microorganisms in a culture device, such as collection of multiple samples, sample loading, sample preparation, sample incubation, and detection of microorganisms in samples. An exemplary embodiment of a modular sample processing and/or detection system can include an automated loading module, a liquid processing module, modular incubator, a second automated loading module, a reader module, and a collector.
    Type: Grant
    Filed: November 30, 2017
    Date of Patent: January 29, 2019
    Assignee: 3M Innovative Properties Company
    Inventors: Phillip A. Bolea, Jon A. Kirschhoffer
  • Patent number: 10163223
    Abstract: A two-dimensional code is attached to a location of a reagent storage unit which is visually recognizable from the outside, and a coordinate position of the two-dimensional code in a coordinate system of the two-dimensional code and coordinate information of an installation position of a reagent bottle are held. After that, an image of the two-dimensional code is captured by a portable terminal so that a coordinate system of an image capture unit of the portable terminal is converted into the coordinate system of the two-dimensional code using AR technology. The coordinate information of the installation position of the reagent bottle in the coordinate system of the two-dimensional code is regarded as positional coordinates in the captured image on the basis of the conversion, thereby ascertaining the position of the reagent bottle on the captured image and displaying the ascertained position on a display unit.
    Type: Grant
    Filed: February 5, 2016
    Date of Patent: December 25, 2018
    Assignee: Hitachi High-Technologies Corporation
    Inventor: Shinji Tachibana
  • Patent number: 10101274
    Abstract: An interrogation device for detecting luminescent light produced by analytes in a sample excited by multiple excitation light beams each having individual spectral contents, comprising a plurality of light sources each generating an excitation light beam; at least one detector for detecting the luminescent light produced by the sample; and an optical assembly defining distinct and fixed excitation light paths for each of the excitation light beams from the light sources to a common excitation site on the sample and defining a shared luminescence light path for the luminescent light from the excitation site on sample to the at least one detector, the excitation light paths and the luminescence light path being on a same side of the sample, the optical assembly including sample-side optics projecting the excitation light towards the sample and collecting luminescent light from the sample.
    Type: Grant
    Filed: December 5, 2013
    Date of Patent: October 16, 2018
    Assignees: GenePOC INC., Universite Laval
    Inventors: Hugo Lemieux, Sébastien Chapdelaine, David Béliveau-Viel, Jean-François Gravel
  • Patent number: 10094842
    Abstract: An automatic biochemical analyzer, comprises a reaction wheel comprising an inner ring and an outer ring, wherein the reaction wheel is equally divided into multiple cuvette positions; the inner ring and the outer ring have a photoelectric detection position, a sample injecting position, a reagent injecting position, a sample stirring position, a reagent stirring position and a cuvette cleaning position; the photoelectric detection position of the inner ring is offset relative to that of the outer ring by a first cuvette position along a counterclockwise or clockwise direction; and the sample injecting positions, the reagent injecting positions, the sample stirring positions, and the reagent stirring positions of the inner ring are offset relative to those of the outer ring by a second cuvette position along the same direction, the first cuvette position is equal to the second cuvette position, or a difference between those two is one cuvette position.
    Type: Grant
    Filed: April 25, 2017
    Date of Patent: October 9, 2018
    Assignee: Shenzhen Mindray Bio-Medical Electronics Co., Ltd.
    Inventors: Zhihong Wang, Qisong Liu
  • Patent number: 10081502
    Abstract: An automated analyzer with an on-board fridge for long-term cooling of reagents, and a method for isolating and analyzing an analyte comprising long-term cooling of reagents.
    Type: Grant
    Filed: June 8, 2015
    Date of Patent: September 25, 2018
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Paul Frank, Andreas Gisler, Robert Huesler, Rolf Knobel, Markus Rinderknecht
  • Patent number: 10060938
    Abstract: An analytical instrument architecture provides high analytical test throughput in a compact footprint. A dilution section creates dilutions of a sample, a reaction processing section contains containers for assay reaction and measurement, and a reagent storage section supports reagent storage and supply. Transfer probes move the dilution and reagents to reaction containers. The dilution processing section includes concentric, independently driven rings of dilution containers; the reaction processing section includes concentric rings of reaction containers driven by the same mechanism for parallel processing of assays.
    Type: Grant
    Filed: October 15, 2014
    Date of Patent: August 28, 2018
    Assignee: Siemens Healthcare Diagnotics Inc.
    Inventors: Timothy P. Evers, Gregory D. Ariff, Edward A. Nuzzaci, Edward F. Farina
  • Patent number: 10052442
    Abstract: In a medicament dispensing device (1), when a medicament preparation-containing syringe (11) is replaced, a microprocessor (23) detects the time at which the replacement is performed as the time of the start of use of the preparation, and counts the elapsed time after the use of the preparation has started. Then, the microprocessor (23) notifies the result of the counting by a LCD (10), etc. to the user. Also, the microprocessor (23) detects that a syringe needle for dispensing the preparation has been mounted, and after detecting the mounting of the syringe needle, the microprocessor (23) counts the elapsed time after the start of use of the preparation. When an effective use period has expired, the microprocessor (23) issues a message in a step S17 that the effective period of a medicament has expired.
    Type: Grant
    Filed: August 25, 2015
    Date of Patent: August 21, 2018
    Assignee: PHC HOLDINGS CORPORATION
    Inventors: Atsushi Watanabe, Seiji Kikuchi, Tsuguhiro Kondo
  • Patent number: 10054530
    Abstract: Particle detection systems are disclosed. The particle detection system may include a conduit configured to receive particles removed from a component, and at least one sensor positioned adjacent the conduit. The at least one sensor may be configured to detect a particle characteristic for the particles in the conduit removed from the component. The particle detection system may also include a particle analysis system in communication with the at least one sensor. The particle analysis system may be configured to analyze the particle characteristic for the particles in the conduit to determine if the component is substantially free of particles.
    Type: Grant
    Filed: August 16, 2016
    Date of Patent: August 21, 2018
    Assignee: General Electric Company
    Inventors: Archie Lee Swanner, Jr., Tiffany Muller Craft, Donnell Eugene Crear, Chad Joseph Dulkiewicz, Kassy Moy Hart
  • Patent number: 10041964
    Abstract: In the field of automatic analyzers, as items to be analyzed are increase, various reagents differing in such properties as liquid viscosity and contact angle are being used more frequently, and this trend is expected to continue. Also, reagents now take various forms (e.g., a concentrated reagent to be diluted by the water of an automatic analyzer), and so does dilution water. Such being the case, the invention provides an automatic analyzer capable of sufficient stirring regardless of items to be analyzed. To sufficiently stir a substance to which a reagent has been added, the automatic analyzer is designed to alter stirring conditions after a given amount of time has passed since the addition of that reagent.
    Type: Grant
    Filed: March 29, 2016
    Date of Patent: August 7, 2018
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Chie Yabutani, Shigeki Matsubara
  • Patent number: 10024874
    Abstract: A measurement container supply device. A supply section transfers the measurement container to the predetermined supply position includes a holding section (50) that holds the measurement container, and the holding section (50) has a first groove (52) that is formed to have a width that corresponds to the outer diameter of a body of the measurement container, and a second groove (54) that is formed to have a width that corresponds to the outer diameter of a neck of the measurement container. When the holding section (50) holds the measurement container, the first groove (52) comes in contact with the outer circumferential surface of the body, the second groove (54) comes in contact with the outer circumferential surface of the neck, and a step (56) that is formed by the first groove (52) and the second groove (54) comes in contact with a step that is formed by the body and the neck.
    Type: Grant
    Filed: June 20, 2014
    Date of Patent: July 17, 2018
    Assignee: JEOL Ltd.
    Inventor: Mizuki Nakamura
  • Patent number: 9970951
    Abstract: In the past, genetic testing systems for exclusive use were needed due to the difference in type or property of specimens. Therefore, a genetic testing system includes: an extraction unit; an assay preparation unit; a reading unit; a first conveying mechanism for conveying a sample among the extraction unit, the assay preparation unit, and the reading unit; multiple sample loading units which are provided corresponding to at least two units of the extraction unit, the assay preparation unit, and the reading unit; and multiple second conveying mechanisms which are provided corresponding to the multiple sample loading units and convey test samples to the inside of the system from the sample loading units.
    Type: Grant
    Filed: December 19, 2013
    Date of Patent: May 15, 2018
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Koshi Maeda, Hiroko Fujita, Yoshiyuki Shoji, Ryoji Inaba
  • Patent number: 9862920
    Abstract: The present invention relates to a system for conducting the identification and quantification of micro-organisms, e.g., bacteria, in biological samples. More particularly, the invention relates to a system comprising a disposable cartridge and an optics cup or cuvette having a tapered surface; wherein the walls are angled to allow for better coating and better striations of the light. The system may utilize the disposable cartridge in the sample processor and the optics cup or cuvette in the optical analyzer, wherein the optics cup also has a floor in the shape of an inverted arch.
    Type: Grant
    Filed: December 11, 2013
    Date of Patent: January 9, 2018
    Assignee: POCARED DIAGNOSTICS LTD.
    Inventors: Gal Ingber, Martha J. Rogers
  • Patent number: 9841413
    Abstract: An automatic analysis device includes: a factor storage unit 12b which stores each factor previously specified as a factor that could affect measurement accuracy of each of measurement items, while associating each factor with each measurement item; an abnormality judgment unit 103a which judges the presence/absence of an abnormality in a measurement value of each measurement item on the basis of an approximation formula and approximation formula parameters stored in an approximation formula storage unit 12a; and a factor judgment unit 103b which refers to the results of the judgment by the abnormality judgment unit 103a in a preset order, and would judge as an abnormality factor a factor stored in the factor storage unit 12b in association with a measurement item as an abnormality factor in a case where a plurality of measurement values regarding the measurement item have consecutively been judged to be abnormal.
    Type: Grant
    Filed: July 3, 2013
    Date of Patent: December 12, 2017
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Naomi Ishii, Kumiko Kamihara
  • Patent number: 9841421
    Abstract: The invention relates to a sensor device (100) and a method for the detection of magnetic particles (1) in a sample chamber (2) with a contact surface (11). The sensor device (100) comprises a sensor unit (120, 130) for detecting magnetic particles (1) in a target region (TR) and/or in at least one reference region on the contact surface. Moreover, it comprises a magnetic field generator (140) for generating a magnetic field that shall guide magnetic particles to the contact surface. With the help of these components, an “auxiliary parameter” is determined that is related to the magnetic particles (1) and/or their movement but that is independent of binding processes taking place in the target region between magnetic particles and the contact surface. The auxiliary parameter may for example be related to the degree of mismatch between the positions reached by the magnetic particles (1) under the influence of a magnetic field and the target region (TR).
    Type: Grant
    Filed: November 28, 2011
    Date of Patent: December 12, 2017
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Wendy Uyen Dittmer, Mikhail Mikhaylovich Ovsyanko, Toon Hendrik Evers, Jeroen Hans Nieuwenhuis, Joannes Baptist Adrianus Dionisius Van Zon
  • Patent number: 9835637
    Abstract: Methods and systems can implement queues for an automation system that services a plurality of modules connected to one another by a transport mechanism, a processor can determining a desired queue for a module. An IVD analyzer can include an automation system, a plurality of stations configured to interact with objects transported by the automation system, and one or more processors that maintain a plurality of queues for at least a subset of the plurality of stations in memory and assign a plurality of the objects to each of the plurality of queues. Objects assigned to each of the plurality of queues need not be located physically proximate to a station associated with each of the plurality of queues.
    Type: Grant
    Filed: April 1, 2013
    Date of Patent: December 5, 2017
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Benjamin Samuel Pollack, Colin Mellars, Baris Yagci
  • Patent number: 9810668
    Abstract: A gas chromatography system includes at least one gas chromatography subsystem including at least one injector port, and an autosampler.
    Type: Grant
    Filed: February 19, 2015
    Date of Patent: November 7, 2017
    Assignee: PerkinElmer Health Sciences, Inc.
    Inventor: Timothy Neal
  • Patent number: 9804181
    Abstract: Methods and systems allow characterization of sample vessels and carriers in an automation system to determine any physical deviation from nominal positions. In response, an offset can be calculated and applied when positioning a carrier relative to a station, such as a testing or processing stations (or vice-versa). This may allow for precise operation of an instrument with a sample vessel on an automation track, while compensating for deviation in manufacturing and other tolerances.
    Type: Grant
    Filed: January 14, 2014
    Date of Patent: October 31, 2017
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Ryan German, Benjamin S. Pollack
  • Patent number: 9778277
    Abstract: An apparatus (2) for the automatic testing of substances for carcinogenicity comprises: a plate support (3) on which at least one micro-well plate (1) can be placed; a movable pipetting unit (4) comprising a predetermined number of pipettes (40); a number of containers (5) containing a liquid culture medium (50), the number of containers (5) corresponding to the number of pipettes (40) of the pipetting unit (4); a dish support (6) on which a corresponding number of dishes (60) can be placed, each having a bottom and an upstanding side wall (601); a plurality of spinners (63) for spinning the dishes (60); a plurality of suction cups (62) for placing a lid (600) on each of the dishes; and a plurality of laterally arranged belts (64,65) for transporting the closed dishes (60) to an intermediate storage (8).
    Type: Grant
    Filed: March 19, 2010
    Date of Patent: October 3, 2017
    Assignee: F. Hoffmann-La Roche AG
    Inventors: Dieter Voegelin, Patrick Iaiza, Thomas Zumstein, Tom Kissling
  • Patent number: 9776146
    Abstract: An automated on-touch template bead preparation system is provided and includes a membrane-based emulsion generation subsystems, an emulsion PCR (ePCR) thermocycling plate and subsystem, and a continuous centrifugation emulsion breaking and templated bead collection subsystem. The emulsion generation subsystem provides uniformity in the preparation of an inverse emulsion and may be used to create large or small volume inverse emulsions rapidly and reproducibly. An emulsion-generating device is provided that can supply a continuous stream of an inverse emulsion to a thermocycling subsystem, in automated fashion. The ePCR subsystem can continuously thermocycle an inverse emulsion passed therethrough and includes static temperature zones and a consumable thermocycling plate. The continuous centrifugation subsystem can continuously break a thermally cycled inverse emulsion and collect template beads formed in the aqueous microreactor droplets of the inverse emulsion.
    Type: Grant
    Filed: April 27, 2015
    Date of Patent: October 3, 2017
    Assignee: Life Technologies Corporation
    Inventors: Jonathan Schultz, John Nobile, Brian Reed, Prasanna Krishnan Thwar, Todd Roswech
  • Patent number: 9768001
    Abstract: A method of quantifying a target analyte by mass spectrometry includes obtaining a mass spectrometer signal comprising a first calibrator signal, comprising a second calibrator signal, and potentially comprising a target analyte signal from a single sample comprising a first known quantity of a first calibrator, comprising a second known quantity of a second calibrator, and potentially comprising a target analyte. The first known quantity and the second known quantity are different, and wherein the first calibrator, the second calibrator, and the target analyte are each distinguishable in the single sample by mass spectrometry. The method also includes quantifying the target analyte in the single sample using the first calibrator signal, the second calibrator signal, and the target analyte signal.
    Type: Grant
    Filed: June 6, 2012
    Date of Patent: September 19, 2017
    Assignee: Waters Technologies Corporation
    Inventor: Donald Peter Cooper
  • Patent number: 9766165
    Abstract: An automated microscope slide staining system and staining apparatus and method that features a plurality of individually operable miniaturized pressurizable reaction compartments or a pressurizable common chamber for individually and independently processing a plurality of microscope slides. The apparatus preferably features independently movable slide support elements each having an individually operable heating element.
    Type: Grant
    Filed: February 22, 2016
    Date of Patent: September 19, 2017
    Inventor: Lee H. Angros
  • Patent number: 9752964
    Abstract: A flow cytometry apparatus includes a flow cytometer having a suction or negative-pressure intake probe, a support for a microplate having a plurality of sample wells, and motive elements operatively connected to at least one of the probe and the support for moving the intake probe and the support relative to one another so that the intake probe is sequentially aligned with different sample wells of the microplate. The apparatus has no fluid pumping elements between the support and the flow cytometer so that a bubble-separated sample stream is forced to the flow cytometer solely by virtue of a negative pressure communicated via the intake probe.
    Type: Grant
    Filed: December 17, 2012
    Date of Patent: September 5, 2017
    Assignee: STC.UNM
    Inventors: Bruce S. Edwards, Larry A. Sklar, Ronald D. Salesky
  • Patent number: 9723831
    Abstract: The present invention relaters to a system and methods for automated vitrification of mammalian oocytes or embryos. The system and methods enable automated processing of oocytes or embryos in vitrification solutions; robotically moving vitrification devices that carry processed cells for freezing in liquid nitrogen; automated sealing of the frozen devices; and transferring the sealed devices to an automated storage system for long-term cryopreservation.
    Type: Grant
    Filed: July 30, 2014
    Date of Patent: August 8, 2017
    Inventors: Yu Sun, Jun Liu
  • Patent number: 9709587
    Abstract: An automatic analyzer is capable of performing a preparation process on a reagent used to measure a highly urgent test item even during analysis operation, and is configured as follows. If there is no parameter for the analysis item regarding a new reagent, the parameters are downloaded. If the priority of reagent preparation is “high,” a sample pipetting scheduling process is temporarily stopped. If the priority of reagent preparation is not “high,” it is determined whether a waiting time limit has been exceeded, and if it has, the sample pipetting scheduling process is stopped temporarily, reagent preparation scheduling is performed, and the sample pipetting scheduling process is resumed. If it is determined that the waiting time limit has not been exceeded, if the priority of reagent preparation is “medium,” and if the reagent preparation mechanism is found available, then reagent preparation scheduling is performed.
    Type: Grant
    Filed: December 26, 2012
    Date of Patent: July 18, 2017
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Takaaki Hagiwara, Kazunori Yamazawa, Hiroki Fujita
  • Patent number: 9696331
    Abstract: The device uses a dispensing probe; a dispensing probe drive mechanism having at least one rotation drive shaft as a horizontal drive mechanism for the dispensing probe, a positioning member with a portion, which is contacted by the dispensing probe during positioning, is formed in a circular shape; a contact detection mechanism for detecting contact between the dispensing probe and the positioning member, and a control unit. The control unit drive-controls only one drive shaft into contact with the circular portion of the positioning member, and then drive-controls only one drive shaft other than the previously drive-controlled shaft into contact with the circular portion of the positioning member, and then calculates position information on a center point at a desired position where the dispensing probe is to be positioned, on the basis of position information on each point at which the contact has been detected, or the like.
    Type: Grant
    Filed: May 15, 2012
    Date of Patent: July 4, 2017
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Masaaki Hirano, Kazuhiro Nakamura
  • Patent number: 9678093
    Abstract: An automatic analyzer provided with a roller and a reagent container shoulder presser at the position where an operator inserts a reagent container into the automatic analyzer. The reagent container is pushed while the lid of the reagent container is made to touch the upper side of the roller and the shoulder presser is made to touch the shoulder of the reagent container, and the application of upward force to the lid causes the lid of the reagent container to be half open, after which the reagent container is inserted in the analyzer.
    Type: Grant
    Filed: June 27, 2014
    Date of Patent: June 13, 2017
    Assignees: Hitachi High-Technologies Corporation, Roche Diagnostics Operations, Inc.
    Inventors: Susumu Sakairi, Katsuhiro Kambara, Stephan Sattler, Reinhold Kraemer
  • Patent number: 9645059
    Abstract: In order to introduce a sample X into a particle size distribution measuring apparatus 200 while neither using a large amount of liquid nor leaving the sample X, a sample introduction system that introduces the sample X into the particle size distribution measuring apparatus 200 that measures the particle size distribution of the sample X is adapted to include: a sample load part 20 that has a load space S into which the sample X is loaded, and a lead-out port 20a adapted to lead out the sample X loaded into the load space S; and a liquid supply mechanism 50 adapted to, into the load space S, supply liquid that is mixed with the sample X and provided in order to measure the particle size distribution. In addition, the sample introduction system is also adapted such that the liquid supplied by the liquid supply mechanism 50 is conducted to the lead-out port 20a while circulating along an inner circumferential surface 24 forming the load space S of the sample load part 20.
    Type: Grant
    Filed: May 12, 2016
    Date of Patent: May 9, 2017
    Assignee: HORIBA, LTD.
    Inventors: Takashi Kimba, Akihiro Katanishi
  • Patent number: 9638708
    Abstract: An automatic biochemical analyzer is provided, the analyzer includes a reaction wheel that comprises an inner ring and outer ring, an interval of a photoelectric detection position of the inner ring and that of the outer ring is N cuvette positions along counterclockwise or clockwise direction, and an interval of a sample injecting position, a reagent injecting positions, a sample stirring position and a reagent stirring position of the inter ring and those of the outer ring respectively is M cuvette positions along the same direction, wherein M and N are integers and the difference between M and N is 0 or 1. The analyzer at the premise of ensuring the test flow, reducing wasting number of cuvettes, saving the cost of the whole analyzer, and the size of the reaction wheel will be as small as possible.
    Type: Grant
    Filed: October 17, 2014
    Date of Patent: May 2, 2017
    Assignee: SHENZHEN MINDRAY BIO-MEDICAL ELECTRONICS CO., LTD.
    Inventors: Zhihong Wang, Qisong Liu
  • Patent number: 9632102
    Abstract: Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.
    Type: Grant
    Filed: September 26, 2011
    Date of Patent: April 25, 2017
    Assignee: Theranos, Inc.
    Inventors: Elizabeth Holmes, Sunny Balwani
  • Patent number: 9598723
    Abstract: An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations, or modules, in which discrete aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automatically preparing a specimen sample, incubating the sample at prescribed temperatures for prescribed periods, performing an analyte isolation procedure, and ascertaining the presence of a target analyte. An automated receptacle transporting system moves the reaction receptacles from one station to the next.
    Type: Grant
    Filed: October 17, 2007
    Date of Patent: March 21, 2017
    Assignee: GEN-PROBE INCORPORATED
    Inventors: Kelly G. Ammann, Ralph E. Burns, Ernest V. Hansberry, Glenn A. Horner, Cheryl A. Jakub, John E. Kling, Donald J. Nieglos, Robert E. Schneider, Robert J. Smith
  • Patent number: 9575085
    Abstract: In an automatic analysis device, when an external force acts on a probe guard 26 in a horizontal direction, the probe guard 26 moves in a direction escaping from the external force around a center portion 47 of a test body container installing mechanism 1, and the probe guard 26 is separated from a fixed position. An outer circumferential wall 29 of the probe guard 26 invades a test body sampling mechanism track 28, and thus a risk that a sampling nozzle 23 of a test body sampling mechanism 5 invades the test body container installing mechanism 1 is avoided by the outer circumferential wall 29. When the probe guard 26 is separated from the fixed position, this is detected, and thus the operation of the test body sampling mechanism 5 and the test body container installing mechanism 1 is stopped.
    Type: Grant
    Filed: January 24, 2014
    Date of Patent: February 21, 2017
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Takeshi Setomaru, Masato Ishizawa, Hideyasu Chiba
  • Patent number: 9557264
    Abstract: To enable determination of if there is an influence of foreign-body reactions on the result of quantitative determination conducted with a scattered light measurement method. Proposed is an automatic analysis device including a light source configured to irradiate a reaction solution with light, a plurality of light receivers configured to receive scattered light generated from the reaction solution at different light-receiving angles, a first data processing unit configured to process reaction process data measured by one of the light receivers to quantitatively determine a concentration of a substance in the reaction solution, and a second data processing unit configured to determine if the quantitative determination of the concentration of the substance has been performed normally on the basis of a ratio of a plurality of computed values, the plurality of computed values having been calculated from a plurality of pieces of reaction process data measured by the respective light receivers.
    Type: Grant
    Filed: June 14, 2013
    Date of Patent: January 31, 2017
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Sakuichiro Adachi, Hajime Yamazaki, Masahiko Iijima
  • Patent number: 9540607
    Abstract: Disclosed herein are systems and methods for preparing a plurality of containers having a suspension of a solid wherein the concentrations of the solid in the plurality of containers are substantially similar or the same and the volumes of the suspension in the plurality of containers are substantially similar or the same.
    Type: Grant
    Filed: February 21, 2012
    Date of Patent: January 10, 2017
    Assignee: Cytonet, LLC
    Inventors: Christopher D. Austin, Patricia M. Whelton, Sonya O. Meheux Sherwood
  • Patent number: 9518899
    Abstract: A system and method that enables automated reagent dispensing for tissue stainers. The stainers receive staining protocols from a central controller. The central controller may control a plurality of stainers simultaneously. The stainers obtain information provided on slide identifiers which is communicated to the central controller. The central controller determines a particular staining protocol to apply to a particular slide. The staining protocol is downloaded to the stainer which enables the stainer to operate without additional communication with the central controller. A user may manually initiate a staining protocol or the central controller may operate the stainers on a scheduled basis.
    Type: Grant
    Filed: February 7, 2006
    Date of Patent: December 13, 2016
    Assignee: Sakura Finetek U.S.A., Inc.
    Inventors: Gilles Lefebvre, Patrick P. Jennings
  • Patent number: 9500662
    Abstract: Disclosed is a sample analyzer comprising: a measurement unit including a reagent storage capable of holding a plurality of kinds of reagents, the measurement unit configured to measure a sample by use of a plurality of kinds of reagents held in the reagent storage in combination; a memory in which a calibration curve is stored in association with a reagent set used in creation of the calibration curve; and a controller programmed to perform operations, comprising: in a case where no calibration curve corresponding to a reagent set used in measurement of the sample has been stored, storing, in the memory, information indicating that the reagent set used in the measurement of the sample has been used in measurement, and when creating a calibration curve, automatically extracting the reagent set for which no calibration curve has been stored and for which the information has been stored.
    Type: Grant
    Filed: August 27, 2014
    Date of Patent: November 22, 2016
    Assignee: SYSMEX CORPORATION
    Inventor: Shunsuke Ariyoshi
  • Patent number: 9499778
    Abstract: An integrated automated system comprising a microfluidic cassette, and methods of use thereof, for intracytoplasmic sperm injection assisted fertilization. The microfluidic cassette and the integrated automated system provides a complete set-up of human gametes for assisted in vitro fertilization, including proper cell stage recognition, gamete propulsion via microfluidic currents, microinjection of a spermatozoon into an oocyte, and subsequent embryo culture and monitoring, thus allowing widespread distribution of in vitro insemination by favoring affordability.
    Type: Grant
    Filed: October 15, 2014
    Date of Patent: November 22, 2016
    Assignee: CORNELL UNIVERSITY
    Inventor: Gianpiero D. Palermo
  • Patent number: 9482613
    Abstract: The present disclosure provides instruments and methods for detecting an analyte which are capable of exciting a plurality of luminescence labels and detecting light emitted therefrom. The instrument includes a filter carrier adapted for carrying a plurality of filter portion pairs, each pair related to a luminescence label and comprising a first filter portion for transmitting excitation light, and a second filter portion for transmitting emitted light. The first filter portion of a pair comprises a second filter portion of another pair. Also, the filter portions are arranged such that a pair can be brought into an operative condition whereby a first filter portion is in the excitation beam path and a second filter portion is in the emission beam path. The filter carrier and beam paths may be moved with respect to each other by a moving mechanism so as to bring a pair into operative condition.
    Type: Grant
    Filed: May 16, 2012
    Date of Patent: November 1, 2016
    Assignee: Roche Molecular Systems, Inc.
    Inventor: Alan Furlan
  • Patent number: 9466040
    Abstract: Precise prediction of the state of congestion in an automatic analysis system and adjustment of timings and the order of take-in and take-out of specimens in each of devices prevent increase in TATs of urgent specimens. A device management server for instructing each device to take in or take out specimens in each device determines the current position of each specimen, estimates the staying time of each specimen in one of regions by simulating the operation of each device assuming an initial state in which each specimen is at the current position, causes the simulation unit to perform a simulation, and corrects the timings or order of take-in and take-out of one or more other specimens so that each of the staying times in one of the regions do not exceed a corresponding allowable staying time in the region.
    Type: Grant
    Filed: March 25, 2011
    Date of Patent: October 11, 2016
    Assignee: HITACHI HIGH-TECHNOLOGIES CORPORATION
    Inventors: Yoshiyuki Tajima, Takashi Noguchi, Shigeru Yano, Koji Kamoshida
  • Patent number: 9459269
    Abstract: The clinical analyzer includes a cuvette carrier that is moved in a manner to provide flexible assay timing and variable incubation periods. Multiple assays having such varied incubation times can be run concurrently in random-access, avoiding timing conflicts. Fluid delivery stations are placed around the cuvette carrier in positions that are independent of assay timing. The cuvettes move in unison, in multiples of incremental steps, along a closed geometrical path. The cuvette carrier is movable variable distances in opposite directions in a single time cycle to position specific cuvettes at specific locations for delivery of sample or reagent. The direction of movement of the cuvette carrier is preferably based on a determination of the shortest distance between the cuvette and respective fluid delivery stations. However, in each time cycle there is a net progressive incremental stepwise movement of the cuvettes in a selected direction.
    Type: Grant
    Filed: July 21, 2006
    Date of Patent: October 4, 2016
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventor: Beri J. Cohen
  • Patent number: 9429586
    Abstract: An automatic analyzer includes: first reagent storing means for storing a plurality of the reagent containers; second reagent storing means for storing a replacement reagent container in addition to the first reagent storing means; transfer means for transferring the reagent container from the second reagent storing means to the first reagent means; and a storing portion for storing the reagent container discharged from the second reagent storing means. The automatic analyzer includes control means for exercising control such that the information write means writes reagent information on the information recording medium immediately before the reagent container is transferred from the second reagent storing means to the first reagent storing means or immediately before the reagent container is discharged from the second reagent storing means to the storing portion.
    Type: Grant
    Filed: November 28, 2011
    Date of Patent: August 30, 2016
    Assignees: Hitachi High-Technologies Corporation, Roche Diagnostics Operations Inc.
    Inventors: Atsushi Watanabe, Shigeki Matsubara, Kazuhiro Shimada, Kenji Teshigawara, Osamu Matsumoto, Sylvia Rosenblatt, Peter Wolf, Fridl Lang, Roland Ihrig
  • Patent number: 9423412
    Abstract: Unlike conventional reagent storing means of an analyzing unit having a cold-storage function, replacement reagent storing means having no cold-storage function requires reagent management of a higher order. An automatic analyzer is provided that manages the placing elapsed time for a reagent vessel in replacement reagent storing means 2, compares the placing elapsed time for the reagent with a permissible placing limit value stored as one of analysis parameters for each analysis item, and determines as to whether or not the placing elapsed time exceeds permissible limit value. In this way, the analyzer prevents the degradation of the reagent and automatically transfers the reagent to an analyzing section for performing measurement.
    Type: Grant
    Filed: November 28, 2011
    Date of Patent: August 23, 2016
    Assignees: Hitachi High-Technologies Corporation, Roche Diagnostics Operations Inc.
    Inventors: Sayaka Sarwar, Shigeki Matsubara, Kenji Teshigawara, Emiko Suzuki, Osamu Matsumoto, Sylvia Rosenblatt, Peter Wolf, Fridl Lang, Roland Ihrig
  • Patent number: 9366666
    Abstract: A protective cap 2 is engaged with a latch 10 of a diluent container 5 so as to fix the diluent container 5 at a liquid holding position of a diluent container containing section 11. The engagement is released when the protective cap 2 is set to an open position against the engagement so as to expose an inlet 13. When the protective cap 2 is shifted from the open position to a closed position, the protective cap 2 pushes the diluent container 5 into a liquid discharge position. Thus, it is possible to preserve a diluent for a long period of time and to easily open the diluent container 5 without having to complicate the structure of an analysis apparatus.
    Type: Grant
    Filed: January 22, 2014
    Date of Patent: June 14, 2016
    Assignee: PANASONIC HEALTHCARE HOLDINGS CO., LTD.
    Inventors: Nobuyasu Higashi, Masaaki Kitoh, Hirofumi Sugimoto
  • Patent number: 9322761
    Abstract: A method of inspecting a clinical specimen for a presence of one or more interferents, such as those that might be found within clinical analytical blood specimens by subjecting the specimen to centrifugation to separate the specimen into a red blood cell portion and a blood serum or plasma portion is provided. Subsequent to the centrifuging procedure, the serum or plasma portion of the clinical analytical specimen may be tested for the presence of one or more interferents such as hemolysis, icterus, lipemia, or liquid nonuniformities therein. Additionally, physical dimensional characteristics of the sample container and/or specimen may be determined. Apparatus for carrying out the method are described, as are other aspects.
    Type: Grant
    Filed: August 5, 2010
    Date of Patent: April 26, 2016
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventor: Kerry L. Miller
  • Patent number: 9322767
    Abstract: Devices and methods for performing a point of care blood, cell, and/or pathogen count or a similar blood test. Disclosed herein are systems that can be used to provide rapid, accurate, affordable laboratory-quality testing at the point of care. The systems described herein are capable of imaging and counting individual cells in a prepared cell sample (e.g., a peripheral blood smear or a blood sample prepared in a microfluidic device) or another prepared cell-containing sample without the need for a microscope or other expensive and cumbersome optics. The systems described herein are designed to eliminate or replace expensive, centralized clinical testing equipment and technical personnel. Such systems may include automated data reporting and decision support.
    Type: Grant
    Filed: April 12, 2013
    Date of Patent: April 26, 2016
    Assignee: i-calQ, LLC
    Inventor: Joel R. L. Ehrenkranz
  • Patent number: 9316657
    Abstract: What is disclosed are methods and apparatus for loading or removing samples for testing. The apparatus comprises a sample disk body for holding a sample for testing, a sample disk lid configured to cover at least a part of the sample disk body and comprising a fixed lid which is fixedly attached to the sample disk body and a movable gate which is movable relatively to the fixed lid, and a locking mechanism to lock the movable gate into a closed position. The opening and closing of the movable gate is controlled by the locking mechanism to prevent inadvertent opening of the sample lid while the sample disk is operating.
    Type: Grant
    Filed: April 14, 2010
    Date of Patent: April 19, 2016
    Assignee: SHENZHEN MINDRAY BIO-MEDICAL ELECTRONICS CO., LTD.
    Inventors: Hua Xiao, Qisong Liu, Ping Tian, Kun Liu
  • Patent number: 9274133
    Abstract: According to an embodiment of the disclosure, the analyzer includes a reagent driving disk that accommodates a reagent configured for analysis and that transports the reagent to a desired position, and a fixed disk that has a reagent stand-by position in which to make a reagent container containing the reagent, temporarily stand by, and a magnetic particles stirring position for stirring magnetic particles. A portion of the reagent stand-by position is constituted by a loading system. A reagent container moving unit moves reagent containers containing the reagent, between the reagent driving unit and the fixed disk, according to analytical request status. Providing in a part of the fixed disk the loading system constructed so that reagent containers containing the reagent can be mounted therein during operation enables changing of reagent containers, irrespective of an operational status of the reagent driving disk, and the system to having cold-storage functionality.
    Type: Grant
    Filed: January 27, 2012
    Date of Patent: March 1, 2016
    Assignees: Roche Diagnostics Operations, Inc., Hitachi High-Technologies Corporation
    Inventors: Reinhold Kraemer, Susumu Sakairi, Stephan Sattler, Katsuaki Takahashi
  • Patent number: 9247850
    Abstract: The cooking hob (1) has a support plate (2) made of glass or glass ceramic, a lower magnetic coupling member (5) rotatably arranged below the support plate (2), a drive motor (6) operatively connected for rotating the lower magnetic coupling member (5), and position changing means (33) for moving the lower magnetic coupling member (5) between an operative position, in which the lower magnetic coupling member (5) is close to the support plate (2) and magnetically transmits torque to an upper magnetic coupling member (54) connected to rotary blades (53) installed in a cooking vessel (50) located on the support plate (2), and an inoperative position, in which the lower magnetic coupling member (5) is far enough from the support plate (2) for not magnetically transmitting the torque.
    Type: Grant
    Filed: March 7, 2011
    Date of Patent: February 2, 2016
    Assignee: ELECTRODOMÉSTICOS TAURUS, S.L.
    Inventors: Josep Alet Vidal, Llluis Trench Roca
  • Patent number: 9250229
    Abstract: Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.
    Type: Grant
    Filed: February 18, 2013
    Date of Patent: February 2, 2016
    Assignee: Theranos, Inc.
    Inventor: Elizabeth A. Holmes