Means Is Turntable (circular) Patents (Class 422/64)
  • Patent number: 10908174
    Abstract: According to one embodiment, an automatic analyzing apparatus includes a reagent depository, a reagent storage unit and a probe. The reagent depository stores a first reagent vessel. The reagent storage unit is provided separately from the reagent depository and in which a second reagent vessel is placeable. The probe suctions a reagent contained in the first reagent vessel at a first position which is located above the reagent depository, suctions a reagent contained in the second reagent vessel at a second position which is located above the reagent storage unit, and discharges the reagent suctioned from the first reagent vessel or the second reagent vessel into a reaction vessel at a third position.
    Type: Grant
    Filed: September 15, 2017
    Date of Patent: February 2, 2021
    Assignee: Canon Medical Systems Corporation
    Inventors: Satoshi Matsumoto, Tomohiro Sugimura, Masaaki Iwasaki, Takashi Goto, Arika Kato
  • Patent number: 10890594
    Abstract: The automated analyzer equalizes the temperature inside a reagent container storage apparatus. The automated analyzer is provided with a reagent container storage apparatus that cools a reagent container, the reagent container storage apparatus being provided with: a reagent storage chamber for storing the reagent container, the reagent storage chamber having at least one of the bottom surface and the side surface thereof cooled by a first cooling source; and a transfer member which is arranged to cover the reagent container stored in the reagent storage chamber, and which is thermally connected to the reagent storage chamber.
    Type: Grant
    Filed: April 28, 2016
    Date of Patent: January 12, 2021
    Assignee: HITACHI HIGH-TECH CORPORATION
    Inventors: Yu Niiyama, Takenori Okusa
  • Patent number: 10858697
    Abstract: A nucleic acid analyzer according to one or more embodiments may include a container setting part that sets a second container, a rotation drive part that rotates the container setting part by applying a driving force to a surface of the container setting part, to supply the extraction liquid injected through the injection port to the storages through the flow path by a centrifugal force. A first temperature adjustment part that adjusts a temperature of the second container provided in the container setting part, such that a nucleic acid amplification reaction occurs in the storages, and a detector that detects a nucleic acid amplification reaction which occurs in the storages with the second container provided in the container setting part interposed between the first temperature adjustment part and the detector in a vertical direction.
    Type: Grant
    Filed: October 19, 2018
    Date of Patent: December 8, 2020
    Assignee: SYSMEX Corporation
    Inventors: Toshiyuki Ozawa, Masanori Imazu, Hironori Kobayashi, Nobuhiro Kitagawa, Yoshihiko Kitawaki
  • Patent number: 10850277
    Abstract: A microfluidic device for evaluation of an organic/inorganic scale inhibitor is provided. The device comprises a substrate mountable to a disc for rotation about an axis. The device further comprises a proximal end and a distal end. The substrate defines a sample reservoir, a solvent reservoir, an inhibitor reservoir, and a precipitant reservoir at the proximal end and an analysis chamber at the distal end in fluid communication with the sample, solvent, inhibitor, and precipitant reservoirs. The substrate is constructed to direct one or more of fluids in the sample reservoir, solvent reservoir, inhibitor reservoir, and precipitant reservoir radially outwardly towards the analysis chamber under the influence of centrifugal force when the microfluidic device rotates.
    Type: Grant
    Filed: July 27, 2018
    Date of Patent: December 1, 2020
    Assignee: SCHLUMBERGER TECHNOLOGY CORPORATION
    Inventors: Vincent Joseph Sieben, Cedric Floquet, Farshid Mostowfi
  • Patent number: 10850507
    Abstract: Disclosed is a coating device which draws a pattern of a functional liquid on a substrate. The coating device includes: a substrate holding unit which holds the substrate; a droplet discharging unit which discharges a droplet of the functional liquid on the substrate held by the substrate holding unit; a moving unit which relatively moves the substrate holding unit and the droplet discharging unit in a main scanning direction and a sub scanning direction on a base; a mass measuring unit including a cup which receives the droplet discharged by the droplet discharging unit and a mass measuring device which measures a mass of the functional liquid accumulated in the cup; and a liquid drain unit which drains the functional liquid accumulated in the cup.
    Type: Grant
    Filed: January 29, 2018
    Date of Patent: December 1, 2020
    Assignee: TOKYO ELECTRON LIMITED
    Inventors: Yousuke Mine, Kazuhito Miyazaki
  • Patent number: 10820847
    Abstract: Methods and systems are provided for point-of-care nucleic acid amplification and detection. One embodiment of the point-of-care molecular diagnostic system includes a cartridge and an instrument. The cartridge can accept a biological sample, such as a urine or blood sample. The cartridge, which can comprise one or more of a loading module, lysis module, purification module and amplification module, is inserted into the instrument which acts upon the cartridge to facilitate various sample processing steps that occur in order to perform a molecular diagnostic test.
    Type: Grant
    Filed: October 16, 2019
    Date of Patent: November 3, 2020
    Assignee: Talis Biomedical Corporation
    Inventors: Sayeed Andeshmand, Thomas H. Cauley, III, John Dixon, David Glade, Hédia Maamar, Michael John McAdams, Dzam-Si Jesse Ng, David Alexander Rolfe
  • Patent number: 10816442
    Abstract: In various embodiments, the invention is a versatile, automated system to allow researchers to continuously measure gas flux rates from multiple chambers over time without (or with reduced) need for personnel in the field. The invention is compatible with any high-frequency analyzer or vial filler and most chamber designs.
    Type: Grant
    Filed: August 1, 2018
    Date of Patent: October 27, 2020
    Assignee: U.S. Geological Survey
    Inventors: Sheel Bansal, Peter Gould
  • Patent number: 10766034
    Abstract: An LED-driven optical cavity PCR system and method is disclosed for fast, accurate and reliable PCR based diagnostics. An optical cavity comprising two thin light absorbing metal (AU) films is used for uniform light absorption and subsequent photo thermal light-to-heat conversion is employed for PCR thermal cycling.
    Type: Grant
    Filed: January 23, 2018
    Date of Patent: September 8, 2020
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Luke P. Lee, Jun Ho Son
  • Patent number: 10768079
    Abstract: A microscope slide staining system has a chamber, a plurality of slide support elements, a plurality of spreading devices positionable in association with microscope slides supported on the slide support elements so the spreading devices define a gap between the spreading device and the microscope slide and so the spreading device and the microscope slide are movable relative to one another to spread at least one reagent on the microscope slide independent of the other spreading devices and microscope slides.
    Type: Grant
    Filed: August 19, 2019
    Date of Patent: September 8, 2020
    Inventor: Lee H. Angros
  • Patent number: 10750756
    Abstract: A machine for producing and dispensing liquid and semi-liquid consumer food products such as ice creams, whipped cream, yogurt and the like comprises a container for a basic product of the consumer food product, a feed and treatment circuit for the basic product, comprising a feed pump, dispensing means positioned at an outfeed end of the feed and treatment circuit, and a device for checking the bacterial load of the product during production/dispensing; an electronic control unit controlling and regulating the various steps for measuring the bacterial load.
    Type: Grant
    Filed: March 24, 2014
    Date of Patent: August 25, 2020
    Assignee: ALI GROUP S.R.L.—CARPIGIANI
    Inventors: Gino Cocchi, Roberto Lazzarini, Gianni Zaniboni
  • Patent number: 10697989
    Abstract: This liquid-sealed cartridge includes: a cartridge body including a plurality of liquid storage portions; a seal body configured to seal an opening of each of the plurality of liquid storage portions; and an elastic body disposed so as to be opposed to the plurality of liquid storage portions, the elastic body being configured to form a passage adjacent to the plurality of liquid storage portions. Each of the plurality of liquid storage portions and the passage are configured to be communicated with each other by the corresponding seal body being pushed to be opened through the elastic body.
    Type: Grant
    Filed: October 27, 2017
    Date of Patent: June 30, 2020
    Assignees: SYSMEX CORPORATION, ASTI CORPORATION
    Inventors: Kazuyoshi Horii, Takao Fujiwara, Noriyuki Ogai, Kenpei Onozuka, Yasuhiro Toda
  • Patent number: 10677709
    Abstract: Particle detection cartridges are provided. Aspects of the particle detection cartridges according to certain embodiments include a sample input, a flow channel and a light channel, where the flow channel and light channel are coupled at a detection region such that only light from the detection region can propagate directly through the light channel to a detector. Systems including the cartridges, as well as methods for detecting particles in a sample with the subject particle detection cartridges/systems, are also described. Kits having one or more cartridges are also provided.
    Type: Grant
    Filed: March 29, 2018
    Date of Patent: June 9, 2020
    Assignee: BECTON, DICKINSON AND COMPANY
    Inventors: Jonathan V. Dixon, Jianying Cao, Edward Michael Goldberg
  • Patent number: 10646866
    Abstract: Provided is a microparticle measurement device that can deliver a liquid used in the analysis of microparticles in a stable manner. The microparticle measurement device includes a plurality of first tank units to which a liquid is supplied from the outside, and which are respectively connected in parallel, and a bulb unit that is connected to the plurality of first tank units, and which switches to a state in which it is possible to deliver the liquid to a flow channel through which microparticles flow. According to this microparticle measurement device, in addition to performing liquid delivery from a portion of the plurality of first tank units, in which the replenishment of liquid has been completed, to a flow channel, it is possible to supply liquid from the outside to the plurality of first tank units other than the plurality of first tank units that are delivering liquid.
    Type: Grant
    Filed: June 6, 2017
    Date of Patent: May 12, 2020
    Assignee: SONY CORPORATION
    Inventor: Yosuke Muraki
  • Patent number: 10625258
    Abstract: Microfluidic devices, assemblies, and systems are provided, as are methods of manipulating micro-sized samples of fluids. Microfluidic devices having a plurality of specialized processing features are also provided.
    Type: Grant
    Filed: October 19, 2015
    Date of Patent: April 21, 2020
    Assignee: Applied Biosystems, LLC
    Inventors: Sean M. Desmond, Zbigniew T. Bryning, John S. Shigeura, Gary Lim, Adrian Fawcett, Jacob K. Freudenthal, Gary Bordenkircher
  • Patent number: 10613108
    Abstract: One actuator (a gripper mechanism and reagent bottle lid opening mechanism drive unit 120) drives a gripper mechanism 106 that holds a reagent bottle 10 and a reagent bottle lid opening mechanism 104 that incises a lid of the reagent bottle 10. The gripper mechanism 106 operates to ascend when the reagent bottle lid opening mechanism 104 operates to descend in order to incise the reagent bottle lid 112, and the reagent bottle lid opening mechanism 104 operates to ascend when the gripper mechanism 106 operates to descend in order to hold the reagent bottle 10. The reagent bottle lid opening mechanism 104 and the gripper mechanism 106 operate without interfering with each other's functions.
    Type: Grant
    Filed: February 18, 2016
    Date of Patent: April 7, 2020
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Takamichi Mori, Hitoshi Tokieda
  • Patent number: 10583554
    Abstract: An instrument turntable is presented which allows an instrument to be installed into an automated system, yet that will still allow an operator to use the instrument manually, even while the automated system is running, without ever removing the instrument from the automated system.
    Type: Grant
    Filed: January 21, 2010
    Date of Patent: March 10, 2020
    Assignee: HIGHRES BIOSOLUTIONS, INC.
    Inventors: Michael J. Nichols, Louis J. Guarracina
  • Patent number: 10576435
    Abstract: The invention relates to a dispersion tool (4) that can be cleaned more easily. For this purpose, the dispersion rotor (8) is arranged on the dispersion tool (4) axially moveable between the working position in the shaft tube (5) and the cleaning position outside the shaft tube (5), the dispersion rotor (8), in the cleaning position, being preferably completely arranged outside the shaft tube (5) and therefore being more easily cleanable.
    Type: Grant
    Filed: July 1, 2016
    Date of Patent: March 3, 2020
    Assignee: IKA-Werke GmbH & Co. KG
    Inventor: Axel Kaufmann
  • Patent number: 10578613
    Abstract: Disclosed is a solid support suitable for improving the detection of how different species interact with each other. The solid support has multiple defined areas divided by low dividers, and optionally independent containers divided by high dividers, each container having at least two defined areas. The solid support is typically used in measurements where the total amount of liquid is temporarily reduced during measurement. The solid support extends the possibilities of the measurement system.
    Type: Grant
    Filed: August 31, 2015
    Date of Patent: March 3, 2020
    Assignee: RIDGEVIEW INSTRUMENTS AB
    Inventors: Karl Andersson, John Strandgard
  • Patent number: 10527637
    Abstract: Provided is an automatic analysis device that enables a reagent to be reliably loaded in and loaded out within a stipulated amount of time, even during analysis and without stopping the analysis, and that enables a reagent to be exchanged without causing a long wait for the operator.
    Type: Grant
    Filed: February 5, 2016
    Date of Patent: January 7, 2020
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Hiroki Fujita, Toshiharu Suzuki
  • Patent number: 10514327
    Abstract: An autosampler includes a pressure release operation unit for performing, by controlling operation of a needle drive mechanism and a switching mechanism, before a tip end of a needle is pulled out from an injection port following a state where a sampling channel is disposed between a feeding device and an analytical column, a pressure release operation of switching the switching mechanism in such a way that the sampling channel is not disposed between the feeding device and the analytical column and a system including the sampling channel is made an open system, and of performing standby until a pressure inside the sampling channel is returned to atmospheric pressure.
    Type: Grant
    Filed: July 18, 2017
    Date of Patent: December 24, 2019
    Assignee: SHIMADZU CORPORATION
    Inventor: Takafumi Nakamura
  • Patent number: 10416178
    Abstract: Systems and methods are provided for processing a biological sample. In one embodiment, the method comprises receiving a sample vessel containing the sample; retrieving information from an information storage unit associated with the sample; using said information for selecting at least one cartridge from at least two or more different cartridges, each configured for use with a sample processing device; loading at least one or more reagents onto the cartridge, wherein the one or more reagents to be added are selected based at least in part on the information or instructions derived from the information; and placing the sample vessel in the cartridge.
    Type: Grant
    Filed: September 15, 2015
    Date of Patent: September 17, 2019
    Assignee: Theranos IP Company, LLC
    Inventors: Elizabeth A. Holmes, Adrit Lath
  • Patent number: 10393667
    Abstract: Techniques for optical analysis of fluid samples using sensors and water enhancing agents for in-line measurements with a continuous flow of the fluid samples are provided. In one aspect, a device includes: at least one reagent dispenser located at an introduction point along a conduit, the conduit being configured to contain a flow of a fluid sample; at least one first detector located at a first detection point along the conduit downstream from the introduction point; and at least one second detector located at a second detection point along the conduit downstream from the first detection point, wherein the at least one first detector and the at least one second detector are configured to make optical measurements of the fluid sample. A method employing the device is also provided.
    Type: Grant
    Filed: December 21, 2017
    Date of Patent: August 27, 2019
    Assignee: International Business Machines Corporation
    Inventors: Russell Budd, Minhua Lu, Vince Siu, Evan Colgan
  • Patent number: 10386275
    Abstract: A microscope slide staining system has a chamber, a plurality of slide support elements, a plurality of spreading devices positionable in association with microscope slides supported on the slide support elements so the spreading devices define a gap between the spreading device and the microscope slide and so the spreading device and the microscope slide are movable relative to one another to spread at least one reagent on the microscope slide independent of the other spreading devices and microscope slides.
    Type: Grant
    Filed: August 13, 2018
    Date of Patent: August 20, 2019
    Inventor: Lee H. Angros
  • Patent number: 10350601
    Abstract: A system for isolating cells in at least one of single-cell format and single-cluster format, comprising a reservoir, including a reservoir inlet and a reservoir outlet, configured to receive a biological sample and to receive at least one fluid, a manifold configured to receive and deliver the biological sample and the at least one fluid from the reservoir into a biological sample substrate, the manifold comprising a broad surface comprising a central region configured to receive the biological sample substrate, a set of openings configured to enable fluid flow transmission across the biological sample substrate, a manifold inlet configured to transmit flow from the reservoir the first subset of openings, a manifold outlet configured at a downstream end of the broad surface and coupled to the second subset of openings, the manifold outlet configured to transmit waste fluid from the manifold.
    Type: Grant
    Filed: October 12, 2017
    Date of Patent: July 16, 2019
    Assignee: Celsee Diagnostics, Inc.
    Inventors: Kalyan Handique, Kyle Gleason, Austin Payne, Priyadarshini Gogoi, Christopher Siemer, Yi Zhou, Saedeh Javdani Sepehri
  • Patent number: 10281376
    Abstract: An apparatus for spreading at least one reagent on at least a portion of a microscope slide includes a spreading device positionable in association with a microscope slide in a way that the spreading device defines a gap between the spreading device and the microscope slide and in a way that the spreading device and the microscope slide are movable relative to one another to spread at least one reagent on at least a portion of the microscope. The spreading device has a reservoir in which the at least one reagent is stored in a way that the at least one reagent is dischargeable from the reservoir onto the microscope slide when the spreading device is positioned in association with the microscope slide.
    Type: Grant
    Filed: August 13, 2018
    Date of Patent: May 7, 2019
    Inventor: Lee H. Angros
  • Patent number: 10190089
    Abstract: A modular automated system for sample processing and/or detection of microorganisms is provided. The modular system includes modules that perform at least one function in the process of detecting microorganisms in a culture device, such as collection of multiple samples, sample loading, sample preparation, sample incubation, and detection of microorganisms in samples. An exemplary embodiment of a modular sample processing and/or detection system can include an automated loading module, a liquid processing module, modular incubator, a second automated loading module, a reader module, and a collector.
    Type: Grant
    Filed: November 30, 2017
    Date of Patent: January 29, 2019
    Assignee: 3M Innovative Properties Company
    Inventors: Phillip A. Bolea, Jon A. Kirschhoffer
  • Patent number: 10163223
    Abstract: A two-dimensional code is attached to a location of a reagent storage unit which is visually recognizable from the outside, and a coordinate position of the two-dimensional code in a coordinate system of the two-dimensional code and coordinate information of an installation position of a reagent bottle are held. After that, an image of the two-dimensional code is captured by a portable terminal so that a coordinate system of an image capture unit of the portable terminal is converted into the coordinate system of the two-dimensional code using AR technology. The coordinate information of the installation position of the reagent bottle in the coordinate system of the two-dimensional code is regarded as positional coordinates in the captured image on the basis of the conversion, thereby ascertaining the position of the reagent bottle on the captured image and displaying the ascertained position on a display unit.
    Type: Grant
    Filed: February 5, 2016
    Date of Patent: December 25, 2018
    Assignee: Hitachi High-Technologies Corporation
    Inventor: Shinji Tachibana
  • Patent number: 10101274
    Abstract: An interrogation device for detecting luminescent light produced by analytes in a sample excited by multiple excitation light beams each having individual spectral contents, comprising a plurality of light sources each generating an excitation light beam; at least one detector for detecting the luminescent light produced by the sample; and an optical assembly defining distinct and fixed excitation light paths for each of the excitation light beams from the light sources to a common excitation site on the sample and defining a shared luminescence light path for the luminescent light from the excitation site on sample to the at least one detector, the excitation light paths and the luminescence light path being on a same side of the sample, the optical assembly including sample-side optics projecting the excitation light towards the sample and collecting luminescent light from the sample.
    Type: Grant
    Filed: December 5, 2013
    Date of Patent: October 16, 2018
    Assignees: GenePOC INC., Universite Laval
    Inventors: Hugo Lemieux, Sébastien Chapdelaine, David Béliveau-Viel, Jean-François Gravel
  • Patent number: 10094842
    Abstract: An automatic biochemical analyzer, comprises a reaction wheel comprising an inner ring and an outer ring, wherein the reaction wheel is equally divided into multiple cuvette positions; the inner ring and the outer ring have a photoelectric detection position, a sample injecting position, a reagent injecting position, a sample stirring position, a reagent stirring position and a cuvette cleaning position; the photoelectric detection position of the inner ring is offset relative to that of the outer ring by a first cuvette position along a counterclockwise or clockwise direction; and the sample injecting positions, the reagent injecting positions, the sample stirring positions, and the reagent stirring positions of the inner ring are offset relative to those of the outer ring by a second cuvette position along the same direction, the first cuvette position is equal to the second cuvette position, or a difference between those two is one cuvette position.
    Type: Grant
    Filed: April 25, 2017
    Date of Patent: October 9, 2018
    Assignee: Shenzhen Mindray Bio-Medical Electronics Co., Ltd.
    Inventors: Zhihong Wang, Qisong Liu
  • Patent number: 10081502
    Abstract: An automated analyzer with an on-board fridge for long-term cooling of reagents, and a method for isolating and analyzing an analyte comprising long-term cooling of reagents.
    Type: Grant
    Filed: June 8, 2015
    Date of Patent: September 25, 2018
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Paul Frank, Andreas Gisler, Robert Huesler, Rolf Knobel, Markus Rinderknecht
  • Patent number: 10060938
    Abstract: An analytical instrument architecture provides high analytical test throughput in a compact footprint. A dilution section creates dilutions of a sample, a reaction processing section contains containers for assay reaction and measurement, and a reagent storage section supports reagent storage and supply. Transfer probes move the dilution and reagents to reaction containers. The dilution processing section includes concentric, independently driven rings of dilution containers; the reaction processing section includes concentric rings of reaction containers driven by the same mechanism for parallel processing of assays.
    Type: Grant
    Filed: October 15, 2014
    Date of Patent: August 28, 2018
    Assignee: Siemens Healthcare Diagnotics Inc.
    Inventors: Timothy P. Evers, Gregory D. Ariff, Edward A. Nuzzaci, Edward F. Farina
  • Patent number: 10054530
    Abstract: Particle detection systems are disclosed. The particle detection system may include a conduit configured to receive particles removed from a component, and at least one sensor positioned adjacent the conduit. The at least one sensor may be configured to detect a particle characteristic for the particles in the conduit removed from the component. The particle detection system may also include a particle analysis system in communication with the at least one sensor. The particle analysis system may be configured to analyze the particle characteristic for the particles in the conduit to determine if the component is substantially free of particles.
    Type: Grant
    Filed: August 16, 2016
    Date of Patent: August 21, 2018
    Assignee: General Electric Company
    Inventors: Archie Lee Swanner, Jr., Tiffany Muller Craft, Donnell Eugene Crear, Chad Joseph Dulkiewicz, Kassy Moy Hart
  • Patent number: 10052442
    Abstract: In a medicament dispensing device (1), when a medicament preparation-containing syringe (11) is replaced, a microprocessor (23) detects the time at which the replacement is performed as the time of the start of use of the preparation, and counts the elapsed time after the use of the preparation has started. Then, the microprocessor (23) notifies the result of the counting by a LCD (10), etc. to the user. Also, the microprocessor (23) detects that a syringe needle for dispensing the preparation has been mounted, and after detecting the mounting of the syringe needle, the microprocessor (23) counts the elapsed time after the start of use of the preparation. When an effective use period has expired, the microprocessor (23) issues a message in a step S17 that the effective period of a medicament has expired.
    Type: Grant
    Filed: August 25, 2015
    Date of Patent: August 21, 2018
    Assignee: PHC HOLDINGS CORPORATION
    Inventors: Atsushi Watanabe, Seiji Kikuchi, Tsuguhiro Kondo
  • Patent number: 10041964
    Abstract: In the field of automatic analyzers, as items to be analyzed are increase, various reagents differing in such properties as liquid viscosity and contact angle are being used more frequently, and this trend is expected to continue. Also, reagents now take various forms (e.g., a concentrated reagent to be diluted by the water of an automatic analyzer), and so does dilution water. Such being the case, the invention provides an automatic analyzer capable of sufficient stirring regardless of items to be analyzed. To sufficiently stir a substance to which a reagent has been added, the automatic analyzer is designed to alter stirring conditions after a given amount of time has passed since the addition of that reagent.
    Type: Grant
    Filed: March 29, 2016
    Date of Patent: August 7, 2018
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Chie Yabutani, Shigeki Matsubara
  • Patent number: 10024874
    Abstract: A measurement container supply device. A supply section transfers the measurement container to the predetermined supply position includes a holding section (50) that holds the measurement container, and the holding section (50) has a first groove (52) that is formed to have a width that corresponds to the outer diameter of a body of the measurement container, and a second groove (54) that is formed to have a width that corresponds to the outer diameter of a neck of the measurement container. When the holding section (50) holds the measurement container, the first groove (52) comes in contact with the outer circumferential surface of the body, the second groove (54) comes in contact with the outer circumferential surface of the neck, and a step (56) that is formed by the first groove (52) and the second groove (54) comes in contact with a step that is formed by the body and the neck.
    Type: Grant
    Filed: June 20, 2014
    Date of Patent: July 17, 2018
    Assignee: JEOL Ltd.
    Inventor: Mizuki Nakamura
  • Patent number: 9970951
    Abstract: In the past, genetic testing systems for exclusive use were needed due to the difference in type or property of specimens. Therefore, a genetic testing system includes: an extraction unit; an assay preparation unit; a reading unit; a first conveying mechanism for conveying a sample among the extraction unit, the assay preparation unit, and the reading unit; multiple sample loading units which are provided corresponding to at least two units of the extraction unit, the assay preparation unit, and the reading unit; and multiple second conveying mechanisms which are provided corresponding to the multiple sample loading units and convey test samples to the inside of the system from the sample loading units.
    Type: Grant
    Filed: December 19, 2013
    Date of Patent: May 15, 2018
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Koshi Maeda, Hiroko Fujita, Yoshiyuki Shoji, Ryoji Inaba
  • Patent number: 9862920
    Abstract: The present invention relates to a system for conducting the identification and quantification of micro-organisms, e.g., bacteria, in biological samples. More particularly, the invention relates to a system comprising a disposable cartridge and an optics cup or cuvette having a tapered surface; wherein the walls are angled to allow for better coating and better striations of the light. The system may utilize the disposable cartridge in the sample processor and the optics cup or cuvette in the optical analyzer, wherein the optics cup also has a floor in the shape of an inverted arch.
    Type: Grant
    Filed: December 11, 2013
    Date of Patent: January 9, 2018
    Assignee: POCARED DIAGNOSTICS LTD.
    Inventors: Gal Ingber, Martha J. Rogers
  • Patent number: 9841413
    Abstract: An automatic analysis device includes: a factor storage unit 12b which stores each factor previously specified as a factor that could affect measurement accuracy of each of measurement items, while associating each factor with each measurement item; an abnormality judgment unit 103a which judges the presence/absence of an abnormality in a measurement value of each measurement item on the basis of an approximation formula and approximation formula parameters stored in an approximation formula storage unit 12a; and a factor judgment unit 103b which refers to the results of the judgment by the abnormality judgment unit 103a in a preset order, and would judge as an abnormality factor a factor stored in the factor storage unit 12b in association with a measurement item as an abnormality factor in a case where a plurality of measurement values regarding the measurement item have consecutively been judged to be abnormal.
    Type: Grant
    Filed: July 3, 2013
    Date of Patent: December 12, 2017
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Naomi Ishii, Kumiko Kamihara
  • Patent number: 9841421
    Abstract: The invention relates to a sensor device (100) and a method for the detection of magnetic particles (1) in a sample chamber (2) with a contact surface (11). The sensor device (100) comprises a sensor unit (120, 130) for detecting magnetic particles (1) in a target region (TR) and/or in at least one reference region on the contact surface. Moreover, it comprises a magnetic field generator (140) for generating a magnetic field that shall guide magnetic particles to the contact surface. With the help of these components, an “auxiliary parameter” is determined that is related to the magnetic particles (1) and/or their movement but that is independent of binding processes taking place in the target region between magnetic particles and the contact surface. The auxiliary parameter may for example be related to the degree of mismatch between the positions reached by the magnetic particles (1) under the influence of a magnetic field and the target region (TR).
    Type: Grant
    Filed: November 28, 2011
    Date of Patent: December 12, 2017
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Wendy Uyen Dittmer, Mikhail Mikhaylovich Ovsyanko, Toon Hendrik Evers, Jeroen Hans Nieuwenhuis, Joannes Baptist Adrianus Dionisius Van Zon
  • Patent number: 9835637
    Abstract: Methods and systems can implement queues for an automation system that services a plurality of modules connected to one another by a transport mechanism, a processor can determining a desired queue for a module. An IVD analyzer can include an automation system, a plurality of stations configured to interact with objects transported by the automation system, and one or more processors that maintain a plurality of queues for at least a subset of the plurality of stations in memory and assign a plurality of the objects to each of the plurality of queues. Objects assigned to each of the plurality of queues need not be located physically proximate to a station associated with each of the plurality of queues.
    Type: Grant
    Filed: April 1, 2013
    Date of Patent: December 5, 2017
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Benjamin Samuel Pollack, Colin Mellars, Baris Yagci
  • Patent number: 9810668
    Abstract: A gas chromatography system includes at least one gas chromatography subsystem including at least one injector port, and an autosampler.
    Type: Grant
    Filed: February 19, 2015
    Date of Patent: November 7, 2017
    Assignee: PerkinElmer Health Sciences, Inc.
    Inventor: Timothy Neal
  • Patent number: 9804181
    Abstract: Methods and systems allow characterization of sample vessels and carriers in an automation system to determine any physical deviation from nominal positions. In response, an offset can be calculated and applied when positioning a carrier relative to a station, such as a testing or processing stations (or vice-versa). This may allow for precise operation of an instrument with a sample vessel on an automation track, while compensating for deviation in manufacturing and other tolerances.
    Type: Grant
    Filed: January 14, 2014
    Date of Patent: October 31, 2017
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Ryan German, Benjamin S. Pollack
  • Patent number: 9776146
    Abstract: An automated on-touch template bead preparation system is provided and includes a membrane-based emulsion generation subsystems, an emulsion PCR (ePCR) thermocycling plate and subsystem, and a continuous centrifugation emulsion breaking and templated bead collection subsystem. The emulsion generation subsystem provides uniformity in the preparation of an inverse emulsion and may be used to create large or small volume inverse emulsions rapidly and reproducibly. An emulsion-generating device is provided that can supply a continuous stream of an inverse emulsion to a thermocycling subsystem, in automated fashion. The ePCR subsystem can continuously thermocycle an inverse emulsion passed therethrough and includes static temperature zones and a consumable thermocycling plate. The continuous centrifugation subsystem can continuously break a thermally cycled inverse emulsion and collect template beads formed in the aqueous microreactor droplets of the inverse emulsion.
    Type: Grant
    Filed: April 27, 2015
    Date of Patent: October 3, 2017
    Assignee: Life Technologies Corporation
    Inventors: Jonathan Schultz, John Nobile, Brian Reed, Prasanna Krishnan Thwar, Todd Roswech
  • Patent number: 9778277
    Abstract: An apparatus (2) for the automatic testing of substances for carcinogenicity comprises: a plate support (3) on which at least one micro-well plate (1) can be placed; a movable pipetting unit (4) comprising a predetermined number of pipettes (40); a number of containers (5) containing a liquid culture medium (50), the number of containers (5) corresponding to the number of pipettes (40) of the pipetting unit (4); a dish support (6) on which a corresponding number of dishes (60) can be placed, each having a bottom and an upstanding side wall (601); a plurality of spinners (63) for spinning the dishes (60); a plurality of suction cups (62) for placing a lid (600) on each of the dishes; and a plurality of laterally arranged belts (64,65) for transporting the closed dishes (60) to an intermediate storage (8).
    Type: Grant
    Filed: March 19, 2010
    Date of Patent: October 3, 2017
    Assignee: F. Hoffmann-La Roche AG
    Inventors: Dieter Voegelin, Patrick Iaiza, Thomas Zumstein, Tom Kissling
  • Patent number: 9768001
    Abstract: A method of quantifying a target analyte by mass spectrometry includes obtaining a mass spectrometer signal comprising a first calibrator signal, comprising a second calibrator signal, and potentially comprising a target analyte signal from a single sample comprising a first known quantity of a first calibrator, comprising a second known quantity of a second calibrator, and potentially comprising a target analyte. The first known quantity and the second known quantity are different, and wherein the first calibrator, the second calibrator, and the target analyte are each distinguishable in the single sample by mass spectrometry. The method also includes quantifying the target analyte in the single sample using the first calibrator signal, the second calibrator signal, and the target analyte signal.
    Type: Grant
    Filed: June 6, 2012
    Date of Patent: September 19, 2017
    Assignee: Waters Technologies Corporation
    Inventor: Donald Peter Cooper
  • Patent number: 9766165
    Abstract: An automated microscope slide staining system and staining apparatus and method that features a plurality of individually operable miniaturized pressurizable reaction compartments or a pressurizable common chamber for individually and independently processing a plurality of microscope slides. The apparatus preferably features independently movable slide support elements each having an individually operable heating element.
    Type: Grant
    Filed: February 22, 2016
    Date of Patent: September 19, 2017
    Inventor: Lee H. Angros
  • Patent number: 9752964
    Abstract: A flow cytometry apparatus includes a flow cytometer having a suction or negative-pressure intake probe, a support for a microplate having a plurality of sample wells, and motive elements operatively connected to at least one of the probe and the support for moving the intake probe and the support relative to one another so that the intake probe is sequentially aligned with different sample wells of the microplate. The apparatus has no fluid pumping elements between the support and the flow cytometer so that a bubble-separated sample stream is forced to the flow cytometer solely by virtue of a negative pressure communicated via the intake probe.
    Type: Grant
    Filed: December 17, 2012
    Date of Patent: September 5, 2017
    Assignee: STC.UNM
    Inventors: Bruce S. Edwards, Larry A. Sklar, Ronald D. Salesky
  • Patent number: 9723831
    Abstract: The present invention relaters to a system and methods for automated vitrification of mammalian oocytes or embryos. The system and methods enable automated processing of oocytes or embryos in vitrification solutions; robotically moving vitrification devices that carry processed cells for freezing in liquid nitrogen; automated sealing of the frozen devices; and transferring the sealed devices to an automated storage system for long-term cryopreservation.
    Type: Grant
    Filed: July 30, 2014
    Date of Patent: August 8, 2017
    Inventors: Yu Sun, Jun Liu
  • Patent number: 9709587
    Abstract: An automatic analyzer is capable of performing a preparation process on a reagent used to measure a highly urgent test item even during analysis operation, and is configured as follows. If there is no parameter for the analysis item regarding a new reagent, the parameters are downloaded. If the priority of reagent preparation is “high,” a sample pipetting scheduling process is temporarily stopped. If the priority of reagent preparation is not “high,” it is determined whether a waiting time limit has been exceeded, and if it has, the sample pipetting scheduling process is stopped temporarily, reagent preparation scheduling is performed, and the sample pipetting scheduling process is resumed. If it is determined that the waiting time limit has not been exceeded, if the priority of reagent preparation is “medium,” and if the reagent preparation mechanism is found available, then reagent preparation scheduling is performed.
    Type: Grant
    Filed: December 26, 2012
    Date of Patent: July 18, 2017
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Takaaki Hagiwara, Kazunori Yamazawa, Hiroki Fujita
  • Patent number: 9696331
    Abstract: The device uses a dispensing probe; a dispensing probe drive mechanism having at least one rotation drive shaft as a horizontal drive mechanism for the dispensing probe, a positioning member with a portion, which is contacted by the dispensing probe during positioning, is formed in a circular shape; a contact detection mechanism for detecting contact between the dispensing probe and the positioning member, and a control unit. The control unit drive-controls only one drive shaft into contact with the circular portion of the positioning member, and then drive-controls only one drive shaft other than the previously drive-controlled shaft into contact with the circular portion of the positioning member, and then calculates position information on a center point at a desired position where the dispensing probe is to be positioned, on the basis of position information on each point at which the contact has been detected, or the like.
    Type: Grant
    Filed: May 15, 2012
    Date of Patent: July 4, 2017
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Masaaki Hirano, Kazuhiro Nakamura