Sample Mechanical Transport Means In Or For Automated Analytical System Patents (Class 422/63)
  • Patent number: 11112419
    Abstract: A laboratory distribution system is presented. The system comprises diagnostic laboratory container carriers and a conveyor. The conveyor comprises an endless drive defining a closed-loop conveyor pathway. The system comprises supporting elements attached to the endless drive. The supporting elements receive a container carrier and transport the container carrier in an upright position along a pathway section. The supporting elements are mounted pivotally about a horizontal pivot axis to the drive and structured such that a center of gravity of the supporting element with or without an empty or loaded container carrier is arranged below and vertically aligned with the pivot axis when the supporting element is in an upright position such that each supporting element is free to pivot about the associated pivot axis under the effect of gravitational forces acting on the supporting element for maintaining the supporting elements in an upright position while travelling along the path.
    Type: Grant
    Filed: July 10, 2018
    Date of Patent: September 7, 2021
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Hans van Mierlo, Gottlieb Schacher, Marcel Kaeppeli, Reto Huesser, Andreas Drechsler, Matthias Goetz, Nenad Milicevic
  • Patent number: 11099201
    Abstract: The invention relates to a device (1) for the automated analysis of solids or fluids. Said device comprises a first station (5) having a metering unit (51) for the filling of at least one sample chamber (2) with a specified sample quantity, a second station (6) having at least one measurement device (61) for an analysis of the sample situated in a sample chamber (2) and a third station (7) having an emptying device and cleaning device (71, 72) for the at least one sample chamber (2). Moreover, there is provided a transport device (3) for a revolving transport of the at least one sample chamber (2) from one station to the next until the first station (5) is reached again. According to the invention, the measurement device (61) of the second station (6) is a spherical measurement system, through the interior of which it is possible to guide the at least one sample chamber (2).
    Type: Grant
    Filed: October 12, 2016
    Date of Patent: August 24, 2021
    Assignee: Blue Ocean Nova AG
    Inventor: Joachim Mannhardt
  • Patent number: 11085914
    Abstract: A hematology analyzer is provided. In certain embodiments, the hematology analyzer comprises: a) a flow cell; b) a light source for directing light to the flow cell; c) a plurality of detectors for detecting a plurality of optical characteristics of a blood cell passing through the flow cell; and d) a data analysis workstation programmed to: i. enumerate test blood cells passing through the flow cell; and ii. flag a blood sample as containing lysis-resistant red blood cells or fragile white blood cells.
    Type: Grant
    Filed: April 3, 2017
    Date of Patent: August 10, 2021
    Assignee: Abbott Laboratories
    Inventors: Martin Krockenberger, Richard Bordenkircher, Diana Garrett, John Glazier, James Bearden, Bodo Roemer, Giacomo Vacca
  • Patent number: 11085940
    Abstract: The automatic analyzer includes a sample storage section for accommodating a plurality of samples, a reagent storage section for accommodating a plurality of reagents, an analysis section for carrying out an analysis by reacting the sample with the reagent, a display, a storage section for storing a setting of an operation item to be automatically executed, which is effective only at restarting, and a control section which displays a screen for setting the operation item to be automatically executed upon acceptance of power shutdown operation by an operator during the analysis on the display to accept the setting from the operator, and automatically executes or omits execution of the operation item to be automatically executed, which has been set by the operator in accordance with the setting read from the storage section at the restarting.
    Type: Grant
    Filed: July 11, 2016
    Date of Patent: August 10, 2021
    Assignee: HITACHI HIGH-TECH CORPORATION
    Inventor: Takayuki Noda
  • Patent number: 11059675
    Abstract: The present invention is directed to a system and method for transferring specimen containers between detection instruments. The method may include transporting a specimen container in a locator well to a container transfer station in a first automated detection apparatus; sensing the specimen container at the container transfer station using a first sensor; transferring the specimen container from the container transfer station of the first automated microbial detection apparatus to an automated loading mechanism of a second automated microbial detection apparatus; detecting that the specimen container is positioned over the automated loading mechanism of the second automated microbial detection apparatus using a second sensor; and releasing the specimen container onto the automated loading mechanism of the second automated microbial detection apparatus.
    Type: Grant
    Filed: October 18, 2019
    Date of Patent: July 13, 2021
    Assignee: bioMérieux, Inc.
    Inventors: Thierry Vivet, Michael Belgeri, Walter Clynes
  • Patent number: 11034929
    Abstract: Aspects of the present invention relate to an automated cell culture instrument and to methods for operating such an instrument. In one aspect, the cell culture instrument includes a computing unit and a plurality of electrically controllable resources (e.g., sensors, actuators, etc.). The computing unit receives a protocol, schedules the resources so as to execute the protocol, and operates the resources as scheduled or in response to so as to provide an improved environment for cell culture growth. The computing unit may simulate protocol execution in connection with the scheduling or execution of the protocol.
    Type: Grant
    Filed: November 18, 2016
    Date of Patent: June 15, 2021
    Assignee: Thrive Bioscience, Inc.
    Inventors: Howard Cannon, Keith Moulton
  • Patent number: 11024998
    Abstract: A kit which has a first and second component parts, which are adapted for connection with each other. The first component part has a first array of electrical sensors, two substantially parallel lateral walls on the sides of the electrical connectors, two rails extending along the sides of the array, a front contact point and an overhang for receiving the second part. The second component part has a second array of electrical sensors for connection to the first array, front end configured to fit between the lateral walls of the first connector, and lateral sides having rail reliefs to fit the rails of the first connector. Connection of the first component part and the second component part forms a shoulder that aligns to locate the second array of electrical connectors in correct position for connection to the first array of electrical connectors.
    Type: Grant
    Filed: September 28, 2017
    Date of Patent: June 1, 2021
    Assignee: Oxford Nanopore Technologies Ltd.
    Inventors: David Waterman, Richard Smith
  • Patent number: 11016008
    Abstract: An analysis instrument may perform analytical operations on an analyte that is combined with multiple reagents prior to being introduced into a flow cell. The instrument may include a nozzle sipper that aspirates reagents from a recipient, along with an analyte. The reagents may be directed to a volume and may be repeatedly moved into and out of the volume by cycling of a pump. The reagents may be ejected into a destination recipient with the nozzle sipper promoting vorticity in the recipient to enhance mixing. The repeated aspiration and ejection through the nozzle sipper effectively mixes the reagents and the template in an automated or semi-automated fashion.
    Type: Grant
    Filed: December 13, 2017
    Date of Patent: May 25, 2021
    Assignee: ILLUMINA, INC.
    Inventors: Bradley Kent Drews, Michael Dai Wang, Umberto Ulmanella, James Michael Osmus, Stephen Wayne Clark, Johanna Lynn Whitacre, Steven Scott Phelps, Michelle L. Alvarez, Michael Adalbert Niziolek, Debra Sue Bryan, Joshua Augustin Darland
  • Patent number: 10972641
    Abstract: The present invention provides, among other thing, devices and methods for simple, fast, and sensitive assaying, including imaging.
    Type: Grant
    Filed: February 8, 2018
    Date of Patent: April 6, 2021
    Assignee: Essenlix Corporation
    Inventors: Stephen Y. Chou, Wei Ding, Yufan Zhang, Ji Qi, Jun Tian, Wei Dong
  • Patent number: 10933415
    Abstract: An analysis container comprises a main body; a first chamber that is provided inside the main body and holds a liquid sample; a second chamber; a liquid passage; and an air passage. The liquid passage connects the first chamber and the second chamber, and moves the liquid sample from the first chamber to the second chamber. The air flow chamber connects the first chamber and the second chamber, and moves air from the second chamber to the first chamber.
    Type: Grant
    Filed: August 10, 2016
    Date of Patent: March 2, 2021
    Assignee: PHC HOLDINGS CORPORATION
    Inventors: Masahiro Kouge, Fumiya Matsubara
  • Patent number: 10919399
    Abstract: A vehicle system provided according to one aspect of the present disclosure includes a power transmitter and a vehicle. The power transmitter is placed at one of at least one charge position. The vehicle includes: a power receiver, a capacitor, and a motor. The power receiver wirelessly receives first electric power from the power transmitter, and outputs second electric power deriving from the first electric power. The capacitor stores the second electric power output by the power receiver such that the capacitor is charged from a first voltage Vc1 to a second voltage Vc2. The motor is driven by the second electric power from the capacitor. The vehicle automatically travels a distance Dx along a route from one to a next one of the at least one charge position on the route. The distance Dx satisfies a certain relationship.
    Type: Grant
    Filed: April 28, 2017
    Date of Patent: February 16, 2021
    Assignee: DAIHEN Corporation
    Inventors: Hiroyuki Kotani, Masao Yokota
  • Patent number: 10907129
    Abstract: An apparatus and a method for the automated processing of samples containing biological cells—in particular, of blood samples or other cell samples is provided. The apparatus has a sample receiving device configured to receive samples, an auxiliary material receiving device configured to receive auxiliary materials, a sample carrier receiving device configured to receive sample carriers, a discharge device configured to discharge samples from a discharge position, and a capture device configured to capture discharged samples in a capture position to obtain prepared samples, and at least one temperature control device for controlling the temperature of at least one of the sample carriers. The distance between the discharge position and the capture position can be adjusted to a prespecified height. The method includes wetting a temperature-controlled sample carrier with at least one auxiliary material and discharging the sample onto the wetted temperature-controlled sample carrier from a prespecified height.
    Type: Grant
    Filed: April 28, 2019
    Date of Patent: February 2, 2021
    Assignee: ALS Automated Lab Solutions GmbH
    Inventors: Matthias Opel, David Unglaub, Jens Eberhardt, Gerd Bornmann
  • Patent number: 10900875
    Abstract: An automated system for processing a sample contained in a liquid sample container includes an automated tool head configured to rotate about a first axis, and to translate along a second axis different than the first axis, an analytic element positioner having an analytic element holder configured to releasably grip an analytic element, and a specimen transfer device carried by the tool head, wherein the tool head is configured to automatically position a working end of the specimen transfer device to obtain a specimen from a sample container held in the sample container holder, and to transfer the obtained specimen to an analytic element held by the analytic element holder, respectively, through one or both of rotation of the tool head about the first axis and translation of the tool head along the second axis.
    Type: Grant
    Filed: March 9, 2018
    Date of Patent: January 26, 2021
    Assignee: Hologic, Inc.
    Inventors: Barry F. Hunt, Raymond Jenoski, Ryan Oliva, Michael Cordeiro, Eric Grimes
  • Patent number: 10889002
    Abstract: Systems, methods, and related technologies are disclosed for multi-device robot control. In one implementation, input(s) are received and provided to a personal assistant or another application or service. In response, command(s) directed to an external device are received, e.g., from the personal assistant. Based on the command(s), a robot is maneuvered in relation to a location associated with the external device. Transmission of instruction(s) from the robot to the external device is initiated.
    Type: Grant
    Filed: January 20, 2020
    Date of Patent: January 12, 2021
    Assignee: X-Tend Robotics Inc.
    Inventors: Gavriel Krauss, Harry Fox
  • Patent number: 10882008
    Abstract: An apparatus for processing biological sample is provided, which comprises a semi-permeable membrane column, an adaptor column and a vacuum manifold. The at least one semi-permeable membrane column is configured for accommodating biological sample therein and comprises a curved surface. The at least one adaptor column is configured for accommodating the semi-permeable membrane column therein and comprises a stopping element. The vacuum manifold is configured for creating a vacuum that facilitates flowing of the biological sample into the semi-permeable membrane column through a semi-permeable membrane therein. The stopping element abuts against the curved surface.
    Type: Grant
    Filed: February 2, 2018
    Date of Patent: January 5, 2021
    Assignee: TAIGEN BIOSCIENCE CORPORATION
    Inventor: Chi-Sheng Tai
  • Patent number: 10880468
    Abstract: A metrology system is provided with a transparent workpiece surface mode, for which the system is configured to vary a focus position over a plurality of positions along a Z height direction proximate to a workpiece. An image stack is acquired, wherein each image of the image stack includes a first surface (e.g., an upper surface of the workpiece) that is transparent or semi-transparent and at least a second surface that is at least partially viewable through the first surface. A plurality of focus curves are determined based on the image stack (e.g., with pattern projection utilized for improved contrast), from which first, second, etc. local focus peaks may be determined from each focus curve that correspond to the first, second, etc. surfaces, respectively. An image is displayed (e.g., extended depth of field, 3D) including a selected surface and for which features of the selected/displayed surface may be measured.
    Type: Grant
    Filed: December 19, 2019
    Date of Patent: December 29, 2020
    Assignee: Mitutoyo Corporation
    Inventor: Robert Kamil Bryll
  • Patent number: 10871474
    Abstract: Disclosed is a station, for testing an analyte in a sample, enabling accurate and quick reaction and analysis of the sample and a reagent in one apparatus. To this end, the present disclosure provides a station, which is for testing a sample by means of inserting a cuvette, having a standby chamber on which a collecting member is placed, a sample chamber, a reagent chamber and a detection unit. The station comprises: a housing which has an input/output part into which a cuvette is inserted; a driving unit which is provided inside the housing, horizontally moves the cuvette, vertically moves a collecting member, reacts a sample in a sample chamber and a reagent in a reagent chamber, and injects a reaction result thereof into a detection unit; and an optical reader which is provided on the horizontal movement path of the cuvette and is for analyzing the reaction result.
    Type: Grant
    Filed: November 17, 2017
    Date of Patent: December 22, 2020
    Assignee: BODITECH MED INC.
    Inventors: Byeong Chul Kim, Bong Suk Moon, Younghaeng Lee, Ju Hyoung Bang, Nam Chul Ha, Jae Un An
  • Patent number: 10871438
    Abstract: A system, method, and apparatus are provided for flow cytometry. In one example, the flow cytometry system includes dual laser devices and dual scatter channels to measure velocity of particles in a core stream of sample fluid. The total flow rate of the sample fluid and the sheath fluid around the sample fluid is controlled, and thus held constant, by a feedback control system controlling a vacuum pump based on differential pressure across ends of a flow channel in the flow cell. A stepper flow control valves are disclosed that apply a physical fluid resistance to a flow of sheath fluid in the flow cytometer. The physical fluid resistance regulates a flow rate of the sheath fluid and thereby regulates a flow rate of sample fluid in the flow cytometer.
    Type: Grant
    Filed: November 19, 2017
    Date of Patent: December 22, 2020
    Assignee: Cytek Biosciences, Inc.
    Inventor: David Vrane
  • Patent number: 10837977
    Abstract: A rack includes a container holder that is fixed to a stage and holds a container that contains a liquid to be dispensed and a camera that is fixed to the stage and located in a position where the camera is capable of capturing an image of the container.
    Type: Grant
    Filed: May 4, 2016
    Date of Patent: November 17, 2020
    Assignee: KABUSHIKI KAISHA YASKAWA DENKI
    Inventors: Noriko Abe, Yukio Hashiguchi, Makoto Umeno, Hiroshi Kumagai, Yukiko Sawada, Motohisa Kamei
  • Patent number: 10800130
    Abstract: The invention relates to flexible PCM sheet materials having a high latent thermal energy storage density for the purpose of heat management. The flexible PCM sheet material includes a flexible supporting structure and phase-change-material elements arranged thereon separately in a specific geometry. The phase-change-material elements are geometrically defined structures composed of polymer-bound phase-change material. The flexible PCM sheet materials are characterized by a high latent heat storage capacity and optimized thermal conductivity, are dimensionally stable even in the event of temperature changes and after phase transitions, can be rolled, folded, wound, or cut to size without problems, and can be transported, stored, processed, or used in a single layer or in multiple layers.
    Type: Grant
    Filed: May 19, 2015
    Date of Patent: October 13, 2020
    Assignee: smartpolymer GmbH
    Inventors: Dirk Büttner, Angelo Schütz, Martin Geissenhöner
  • Patent number: 10730053
    Abstract: Provided in part herein are static-defeating apparatus for use in multipipettor systems. Multiple pipette tips can be retained by a static-defeating sheet of material. A multipipettor, having multiple pipettes or nozzles, can engage the pipette tips retained by the sheet. After use, the multipipettor can eject the pipette tips, which sometimes are ejected as a single unit due to the pipette tips being retained by the sheet. In certain embodiments, an apparatus includes a snap plate having one or more holes, and a base rack for ease of mounting.
    Type: Grant
    Filed: December 9, 2015
    Date of Patent: August 4, 2020
    Assignee: BIOTIX, INC.
    Inventors: Scott E. Curry, Arta Motadel, Peter Paul Blaszcak
  • Patent number: 10718568
    Abstract: A sample heating device includes: a rail-shaped disposal rail extending in one direction in a horizontal plane so that sample boats after heating are arranged and placed in a straight line; a disposal tray that houses the sample boat pushed-out from one end of the disposal rail; a sample boat conveying portion that places the sample boat after the heating at a predetermined placing position on the disposal rail; and a sample boat push-out portion that is positioned closer to the other end side of the disposal rail than the placing position when the sample boat is placed on the disposal rail and that is displaced toward the one end side of the disposal rail after the sample boat is placed at the placing position to slide the sample boats on the disposal rail toward the one end side.
    Type: Grant
    Filed: January 11, 2018
    Date of Patent: July 21, 2020
    Assignee: SHIMADZU CORPORATION
    Inventor: Akioki Nakamori
  • Patent number: 10702990
    Abstract: The present invention relates to a robot comprising a horizontal or horizontally slanted transparent experiment layer being adapted to support items at arbitrary positions on or in the experiment layer, and a moveable sensor arranged below the transparent experimental layer said sensor being configured for providing a sensor signal indicative of item(s)' location on the experiment layer, an actuator arranged for being moved into different positions above the horizontal transparent layer a display device being configured for visually representing located item(s) a user input device configured for receiving information as to operation of the actuator.
    Type: Grant
    Filed: March 17, 2017
    Date of Patent: July 7, 2020
    Assignee: Flow Robotics A/S
    Inventors: Kasper Støy, Andrés Faíña Rodríguez-Vila, Farzad Nejatimoharrami
  • Patent number: 10684200
    Abstract: An automatic tissue staining device includes a supply head that supplies a treatment fluid, a horizontal direction movement unit that moves the supply head in a horizontal direction, and a holding unit that holds a plurality of glass slides on which samples are set. The automatic tissue staining device further includes a control unit that judges an occupancy status of the horizontal direction movement unit in a condition that one or more of the glass slides are situated in a first region prior to supplying the treatment fluid from the supply head to one or more samples in the first region, suspends a start of a treatment for the samples in the first region when the horizontal direction movement unit is occupied, and permits the treatment for the samples in the first region when the horizontal direction movement unit is not occupied.
    Type: Grant
    Filed: September 24, 2018
    Date of Patent: June 16, 2020
    Assignee: NICHIREI BIOSCIENCES INC.
    Inventors: Toshiyuki Kasamatsu, Noboru Horikoshi
  • Patent number: 10677276
    Abstract: According to an aspect, a fixing structure includes: a supporting plate; a substrate arranged on a first surface of the supporting plate, the substrate including a component that is arranged on a surface opposite to the supporting plate and projects toward opposite to the supporting plate; a male screw that is fixed to the supporting plate so that a first end projects from the first surface to pass through the substrate, and a second end opposite to the first end does not project from a second surface opposite to the first surface of the supporting plate; and a female screw that is screwed with the first end of the male screw projecting from the substrate.
    Type: Grant
    Filed: May 16, 2016
    Date of Patent: June 9, 2020
    Assignee: Japan Display Inc.
    Inventor: Yuichi Tsubaki
  • Patent number: 10641772
    Abstract: The present disclosure provides methods, device, assemblies, and systems for dispensing and visualizing single cells. For example, provided herein are systems and methods for dispensing a dispense volume into a plurality of wells of a multi-well device, where, on average, a pre-determined number of cells (e.g., 1-20) are present in the dispense volume, and determining, via a cellular label, the number of cells present in each of the plurality of wells. Such dispensing and cell detection may be repeated a number of times with respect to wells identified as having less than the pre-determined number of cells in order increase the number wells in the multi-well device containing the desired number (e.g., a single cell).
    Type: Grant
    Filed: February 20, 2016
    Date of Patent: May 5, 2020
    Assignee: TAKARA BIO USA, INC.
    Inventors: Alain-Albert Mir, Thomas D. Schaal, Chun-Wah Lin, Shanavaz Loharasp D. Nasarabadi, Jude Dunne, Maithreyan Srinivasan, Patricio Espinoza
  • Patent number: 10627418
    Abstract: Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.
    Type: Grant
    Filed: May 23, 2016
    Date of Patent: April 21, 2020
    Assignee: Theranos IP Company, LLC
    Inventors: James Wasson, Pey-Jiun Ko, Joy Roy, Elizabeth A. Holmes
  • Patent number: 10620203
    Abstract: The present invention relates to an leucocyte antigen mediated microfluidic assay and a microfluidic device for analyzing a subjects' body fluids containing leucocytes to determine if the subject has been previously exposed to a predetermined antigen.
    Type: Grant
    Filed: April 6, 2015
    Date of Patent: April 14, 2020
    Assignee: Advanced Animal Diagnostics, Inc.
    Inventors: Rodolfo R. Rodriguez, Douglas J. Darr
  • Patent number: 10613106
    Abstract: Disclosed is a reaction vessel handling apparatus adapted for use in a biological fluid testing apparatus. The reaction vessel handling apparatus includes an incubation member and wash member that are overlapping. A transfer device transfers reaction vessels between the incubation member and wash member at the overlapping portions. Incubation and wash members may be rings. Testing apparatus (e.g., immunoassay apparatus or clinical analyzer apparatus) including the reaction vessel handling apparatus and methods of operating the apparatus are provided, as are other aspects.
    Type: Grant
    Filed: April 15, 2015
    Date of Patent: April 7, 2020
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Beri Cohen, Nicolae Dumitrescu
  • Patent number: 10593513
    Abstract: An examination container includes a main body, a membrane assembly and a cover. The main body has an accommodating trough for holding sample. The membrane assembly covers an opening end of the accommodating trough. The membrane assembly includes a support body and a membrane. The support body has a first surface and a second surface, wherein the support body is flat and has a first through-hole penetrating through the first surface and the second surface. The membrane is arranged on the second surface side of the support body and has a second through-hole. The second through-hole is opposite to the first through-hole and allows a charged particle beam to pass the second through-hole. The cover is detachably connected to the main body to secure the membrane assembly. The membrane assembly is easy to replace and uses less consumables. An electron microscope using the abovementioned examination container is also disclosed.
    Type: Grant
    Filed: July 18, 2018
    Date of Patent: March 17, 2020
    Assignee: TAIWAN ELECTRON MICROSCOPE INSTRUMENT CORPORATION
    Inventors: Tsu-Wei Huang, Jia-Ling Wu, Shih-Yi Liu, Maochan Chang
  • Patent number: 10557862
    Abstract: The present invention relates to systems and methods of determining quality compliance for a set of biological sample testing devices used with one or more test instruments at the point-of-care in a hospital or other location that delivers medical care. In particular, the systems and methods ensure that only biological sample testing devices that pass a quality assurance protocol are used for point-of-care testing.
    Type: Grant
    Filed: May 4, 2016
    Date of Patent: February 11, 2020
    Assignee: Abbott Point of Care Inc.
    Inventors: Paul Glavina, Jody Ann Tirinato
  • Patent number: 10557863
    Abstract: Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.
    Type: Grant
    Filed: July 1, 2015
    Date of Patent: February 11, 2020
    Assignee: Theranos IP Company, LLC
    Inventors: Elizabeth A. Holmes, Michael Chen, John K. Frankovich, Samartha Anekal, Adrit Lath, Alexander Loo, Chinmay Pangarkar, Joy Roy, Timothy Smith, Daniel Young
  • Patent number: 10532360
    Abstract: The system for management of rack and tube positions for clinical chemistry laboratories includes tubes (10) capable of containing human biological material, a rack (20) configured for receiving and/or holding the tubes (10) to be stocked, a supporting base (30) configured for supporting the rack (20) thereon, a reader (50) configured for reading an identifier (RID) of the rack (20) to be put onto the supporting base (30) and an identifier (TID) of the tube to be put into the rack (20), a camera (40) for detecting the rack (20) on the supporting base (30), and at least one of the tubes (10) into the rack (20), a processing unit (60) for mapping the detected rack (20) into a plurality of allowed positions (Pi) and the detected tube (10) into a tube position (P) included in the plurality of allowed positions (Pi).
    Type: Grant
    Filed: September 28, 2012
    Date of Patent: January 14, 2020
    Assignee: OMNILAB TECHNOLOGIES S.R.L.
    Inventors: Luca Birolini, Christian Otto
  • Patent number: 10512915
    Abstract: A nucleic acid amplifier comprises a holder 3 which is provided with a plurality of temperature control blocks 10 each designed to hold at least one reaction vessel 105 storing a reaction solution. The temperature of the reaction solution in each reaction vessel 105 is controlled individually by using temperature control devices 14 and 15 arranged in each of the temperature control blocks 10. The temperature that is set in each temperature control block 10 and the timing for temperature changes are controlled independently of the temperatures of other temperature control blocks 10. This configuration makes it possible to provide a nucleic acid amplifier and a nucleic acid inspection device (employing the nucleic acid amplifier) capable of processing multiple types of samples differing in the protocol in parallel (parallel processing) and starting a process for a different sample even when there is a process in execution.
    Type: Grant
    Filed: April 28, 2011
    Date of Patent: December 24, 2019
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Minoru Sano, Yoshiyuki Shoji, Masato Ishizawa, Kimikazu Sugiyama
  • Patent number: 10493457
    Abstract: A sample storage including a frame and an array of sample container holding areas disposed within the frame where a spacing between adjacent sample container holding areas is independent of a gripping area for sample containers held by the sample storage.
    Type: Grant
    Filed: March 27, 2015
    Date of Patent: December 3, 2019
    Assignee: Brooks Automation, Inc.
    Inventors: Etienne Croquette, Rhett Affleck, Robin Grimwood
  • Patent number: 10466263
    Abstract: The invention is in the field of automatic analysis devices and relates to a heatable pipetting device for an automatic analysis device and a method for providing a reaction mixture. The pipetting device comprises a pipetting needle having two temperature sensors at different distances to the tip of the pipetting needle.
    Type: Grant
    Filed: August 5, 2016
    Date of Patent: November 5, 2019
    Assignee: Siemens Healthcare Diagnostics Products Gmbh
    Inventor: Christian Verhalen
  • Patent number: 10458999
    Abstract: Provided is a cell suction system that supports suction work of a substance within a cell. The cell suction system includes: a suction section including a tubular tip configured to suction the substance from the inside of the cell received in a container; a detection section configured to acquire information on a front end part of the tip; and a conveyance section configured to make the suction section three-dimensionally movable, the conveyance section being configured to move the suction section to guide the front end part of the tip attached to the suction section into one specific cell based on the information obtained in the detection section.
    Type: Grant
    Filed: December 4, 2015
    Date of Patent: October 29, 2019
    Assignee: Yokogawa Electric Corporation
    Inventors: Takayuki Kei, Takuya Azuma, Hironori Takai
  • Patent number: 10450144
    Abstract: The present invention is directed to a system and method for transferring specimen containers between detection instruments. The method may include transporting a specimen container in a locator well to a container transfer station in a first automated detection apparatus; sensing the specimen container at the container transfer station using a first sensor; transferring the specimen container from the container transfer station of the first automated microbial detection apparatus to an automated loading mechanism of a second automated microbial detection apparatus; detecting that the specimen container is positioned over the automated loading mechanism of the second automated microbial detection apparatus using a second sensor; and releasing the specimen container onto the automated loading mechanism of the second automated microbial detection apparatus.
    Type: Grant
    Filed: May 26, 2017
    Date of Patent: October 22, 2019
    Assignee: bioMerieux, Inc.
    Inventors: Thierry Vivet, Michael Belgeri, Walter Clynes
  • Patent number: 10452035
    Abstract: The invention relates to a configuration control device for a laboratory instrument, a laboratory instrument with a configuration control device for instrument-controlled treatment of at least one laboratory sample and a method for configuring the laboratory instrument by means of the configuration control device. By using user-dependent configuration data, the requirement for the user of having to perform a completely manual configuration of the laboratory instrument, which is effected by the user-dependent configuration data, is dispensed with.
    Type: Grant
    Filed: October 7, 2014
    Date of Patent: October 22, 2019
    Inventors: Wolfgang Goemann-Thoss, Wolf Wente, Andreas Thieme, Jan-Gerd Frerichs, Christiane Markau, Jan-Hendrik Hacker
  • Patent number: 10441266
    Abstract: A method of treating a heart of a patient is provided, including implanting a first tissue anchor in cardiac tissue of the patient, the first tissue anchor attached to one or more tethers that are fixed to a coupling element. A second tissue anchor is implanted in the patient. The coupling element is coupled to a first coupling site of the second tissue anchor, thereby coupling the first tissue anchor to the second tissue anchor via the one or more tethers. Thereafter, after allowing at least 24 hours for tissue growth on the first tissue anchor to strengthen anchoring of the first tissue anchor in the cardiac tissue, tension is increased between the first and the second tissue anchors by decoupling the coupling element from the first coupling site and coupling the coupling element to a second coupling site of the second tissue anchor. Other embodiments are also described.
    Type: Grant
    Filed: February 23, 2018
    Date of Patent: October 15, 2019
    Assignee: 4Tech Inc.
    Inventors: Paolo Denti, Andrea Guidotti, Kevin Lynn, Idan Tobis
  • Patent number: 10429403
    Abstract: A head device for mounting a dispensing tip includes a piston member, a first shaft member to move the piston member in an up-down direction, a tubular rod including a tubular space having a cylinder space in which the piston member is housed to move in the up-down direction and including a tip mounting portion into which a base end portion of the dispensing tip is fitted, a first frame equipped with the first shaft member and the tubular rod, a second shaft member engaging with the first frame to move the first frame, a second frame equipped with the second shaft member and including a guide portion configured to guide movement of the tubular rod in the up-down direction in association with the movement of the first frame in the up-down direction, and a shaft controller configured to control operation of the first and second shaft members.
    Type: Grant
    Filed: June 17, 2014
    Date of Patent: October 1, 2019
    Assignee: YAMAHA HATSUDOKI KABUSHIKI KAISHA
    Inventors: Saburo Ito, Yukimasa Osada, Yohei Izume
  • Patent number: 10416136
    Abstract: A controlling apparatus 110 to control an operation of an analyzing apparatus 1 and make the analyzing apparatus 1 execute a predetermined analysis, the controlling apparatus 110 including: a communicating module 60 that maintains reception of electricity when the analyzing apparatus 1 is in a power-on state, and is capable of receiving a control signal from an external apparatus 2 at all times; and a unit power controlling section 23 for acquiring the control signal through the communicating module 60, stopping electricity supply to a unit 31, 321, 322, 323 and/or 324 of the analyzing apparatus 1 at a first timing based on the control signal, and restarting the electricity supply to the unit 31, 321, 322, 323 and/or 324 at a second timing based on the control signal, so as to effectively suppress the electricity consumption when the analysis is not executed and facilitate the restart of the analysis.
    Type: Grant
    Filed: June 24, 2014
    Date of Patent: September 17, 2019
    Assignee: SHIMADZU CORPORATION
    Inventors: Shinji Kanazawa, Fuyuki Okamoto
  • Patent number: 10401275
    Abstract: The invention relates to an analysis method for supporting classification, a determination method for determining analysis parameters Ys, Ei, Ii, ?i for the analysis method, a computer program product, and an optical analysis system for supporting classification, with which system analysis parameters Ys, Ei, Ii, ?i can be defined on the basis of first and second calibration data. The parameters provide classification support according to the discriminant analysis and on the basis of measured values Pi of optical characteristics i, in particular of organic dispersions, and the information content thereof for classification, in particular the diagnosis of disease; and permit a classification proposal or a diagnosis proposal in comparison with a threshold Ys.
    Type: Grant
    Filed: August 5, 2014
    Date of Patent: September 3, 2019
    Assignee: Siemens Healthcare Diagnostics Products GmbH
    Inventors: Barbara Kavsek, Peter Lederer, Peter Taal, Jan van den Boogaart
  • Patent number: 10401350
    Abstract: A sample analyzer prepares a measurement sample from a blood sample or a body fluid sample which differs from the blood sample; measures the prepared measurement sample; obtains characteristic information representing characteristics of the components in the measurement sample; sets either a blood measurement mode for measuring the blood sample, or a body fluid measurement mode for measuring the body fluid sample as an operating mode; and measures the measurement sample prepared from the blood sample by executing operations in the blood measurement mode when the blood measurement mode has been set, and measuring the measurement sample prepared from the body fluid sample by executing operations in the body fluid measurement mode that differs from the operations in the blood measurement mode when the body fluid measurement mode has been set, is disclosed. A computer program product is also disclosed.
    Type: Grant
    Filed: December 10, 2018
    Date of Patent: September 3, 2019
    Assignees: Sysmex Corporation, Sysmex America, Inc.
    Inventors: Takaaki Nagai, Noriyuki Narisada, Daigo Fukuma, Masanori Imazu
  • Patent number: 10386380
    Abstract: A sample processing system is configured for analyzing, preprocessing, or carrying out other operations for a biological sample such as blood or urea. With the sample processing system, it is possible to store samples to be stored in a thermally insulated state or specimens required for accuracy control in the thermally insulated state for preventing evaporation or denaturing of the samples and specimens. Also it is possible to carry in or out the samples, rack by rack, according to necessity. Further, the sample processing system is provided with a buffer unit in a cold container having a capability for cold storage and also by accessing a sample rack at random for carrying in or out a rack with a transfer mechanism provided outside of the cold container.
    Type: Grant
    Filed: December 5, 2017
    Date of Patent: August 20, 2019
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Kuniaki Onizawa, Koichi Obari, Junichi Oizumi, Shigemi Oba, Tetsuaki Abe
  • Patent number: 10381463
    Abstract: Embodiments are directed to a method and resulting structures for smoothing the sidewall roughness of a post-etched film. A sacrificial layer is formed on a substrate. A patterned mask is formed by removing portions of the sacrificial layer to expose a surface of the substrate. The sidewalls of the patterned mask are smoothed and a target layer is formed over the patterned mask and the substrate. Portions of the target layer are removed to expose a surface of the patterned mask and the patterned mask is removed.
    Type: Grant
    Filed: January 19, 2018
    Date of Patent: August 13, 2019
    Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Kafai Lai, Hari V. Mallela, Hiroyuki Miyazoe, Reinaldo A. Vega, Rajasekhar Venigalla
  • Patent number: 10359443
    Abstract: An automatic fecal occult blood detecting analyzer used to detect a sample box is provided. The analyzer has a feeding chain and a main conveying chain. A plurality of clamping devices for clamping the sample box are provided on the feeding chain and the main conveying chain, respectively. A transferring device of the analyzer transfers the sample box from the feeding chain to the main conveying chain. The analyzer also has a pressing device and an image acquisition device for acquiring tape information presented on test strips of the sample box on the main conveying chain. Continuous detection and accurate location of a plurality of the sample boxes can be implemented without turning over and tilting the sample boxes.
    Type: Grant
    Filed: December 24, 2015
    Date of Patent: July 23, 2019
    Assignee: W.H.P.M. BIORESEARCH AND TECHNOLOGY CO., LTD.
    Inventors: John Wan, Chunhai Zou, Qinghai Xia, Jie Liu
  • Patent number: 10351843
    Abstract: The present invention relates to an automated analytical system and an automated method for separating and detecting an analyte, as well as an automated analytical instrument.
    Type: Grant
    Filed: December 22, 2015
    Date of Patent: July 16, 2019
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Renato Belz, Andreas Gisler, Robert Huesler, Rolf Knobel, Christian Thalmann
  • Patent number: 10330691
    Abstract: A diagnostic analyzer includes a track, a light-blocking member, a motor, and an optical testing device. The track moves a reaction vessel held by the track. The light-blocking member is disposed adjacent to the track. The light-blocking member moves from a first position apart from the track to a second position closer to the track. When the light-blocking member is disposed in the first position a sample contained within the reaction vessel held by the track is exposed to light. When the light-blocking member is disposed in the second position the sample contained within the reaction vessel held by the track is blocked from exposure to the light. The motor moves the light-blocking member between the first and the second positions. The optical testing device is disposed adjacent to the track for optically testing the sample contained within the reaction vessel held by the track when the at least one light-blocking member is disposed in the second position.
    Type: Grant
    Filed: October 31, 2016
    Date of Patent: June 25, 2019
    Assignee: ABBOTT LABORATORIES
    Inventors: Joseph P. Donohue, Ryan Patrick Johnson
  • Patent number: 10330692
    Abstract: The purpose of the present invention is to provide an automatic analysis device that combines a biochemical analysis unit and a blood coagulation analysis unit and has a high processing capacity while reducing device cost and life-cycle cost. An automatic analysis device is characterized in that when a synthetic-substrate item or latex-agglutination item from among synthetic-substrate, latex-agglutination, and clotting-time blood-coagulation-test items is made to be a first test item and the clotting-time item is made to be a second test item, if there is a measurement request for the first test item and second test item in the same specimen rack, a control unit determines the conveyance path of the specimen rack such that the first test item is measured using a biochemical analysis unit and the second test item is measured using a coagulation time analysis unit and controls a conveyance line.
    Type: Grant
    Filed: November 5, 2014
    Date of Patent: June 25, 2019
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Akihisa Makino, Chie Yabutani, Masato Ishizawa