Sample Mechanical Transport Means In Or For Automated Analytical System Patents (Class 422/63)
  • Patent number: 10730053
    Abstract: Provided in part herein are static-defeating apparatus for use in multipipettor systems. Multiple pipette tips can be retained by a static-defeating sheet of material. A multipipettor, having multiple pipettes or nozzles, can engage the pipette tips retained by the sheet. After use, the multipipettor can eject the pipette tips, which sometimes are ejected as a single unit due to the pipette tips being retained by the sheet. In certain embodiments, an apparatus includes a snap plate having one or more holes, and a base rack for ease of mounting.
    Type: Grant
    Filed: December 9, 2015
    Date of Patent: August 4, 2020
    Assignee: BIOTIX, INC.
    Inventors: Scott E. Curry, Arta Motadel, Peter Paul Blaszcak
  • Patent number: 10718568
    Abstract: A sample heating device includes: a rail-shaped disposal rail extending in one direction in a horizontal plane so that sample boats after heating are arranged and placed in a straight line; a disposal tray that houses the sample boat pushed-out from one end of the disposal rail; a sample boat conveying portion that places the sample boat after the heating at a predetermined placing position on the disposal rail; and a sample boat push-out portion that is positioned closer to the other end side of the disposal rail than the placing position when the sample boat is placed on the disposal rail and that is displaced toward the one end side of the disposal rail after the sample boat is placed at the placing position to slide the sample boats on the disposal rail toward the one end side.
    Type: Grant
    Filed: January 11, 2018
    Date of Patent: July 21, 2020
    Assignee: SHIMADZU CORPORATION
    Inventor: Akioki Nakamori
  • Patent number: 10702990
    Abstract: The present invention relates to a robot comprising a horizontal or horizontally slanted transparent experiment layer being adapted to support items at arbitrary positions on or in the experiment layer, and a moveable sensor arranged below the transparent experimental layer said sensor being configured for providing a sensor signal indicative of item(s)' location on the experiment layer, an actuator arranged for being moved into different positions above the horizontal transparent layer a display device being configured for visually representing located item(s) a user input device configured for receiving information as to operation of the actuator.
    Type: Grant
    Filed: March 17, 2017
    Date of Patent: July 7, 2020
    Assignee: Flow Robotics A/S
    Inventors: Kasper Støy, Andrés Faíña Rodríguez-Vila, Farzad Nejatimoharrami
  • Patent number: 10684200
    Abstract: An automatic tissue staining device includes a supply head that supplies a treatment fluid, a horizontal direction movement unit that moves the supply head in a horizontal direction, and a holding unit that holds a plurality of glass slides on which samples are set. The automatic tissue staining device further includes a control unit that judges an occupancy status of the horizontal direction movement unit in a condition that one or more of the glass slides are situated in a first region prior to supplying the treatment fluid from the supply head to one or more samples in the first region, suspends a start of a treatment for the samples in the first region when the horizontal direction movement unit is occupied, and permits the treatment for the samples in the first region when the horizontal direction movement unit is not occupied.
    Type: Grant
    Filed: September 24, 2018
    Date of Patent: June 16, 2020
    Assignee: NICHIREI BIOSCIENCES INC.
    Inventors: Toshiyuki Kasamatsu, Noboru Horikoshi
  • Patent number: 10677276
    Abstract: According to an aspect, a fixing structure includes: a supporting plate; a substrate arranged on a first surface of the supporting plate, the substrate including a component that is arranged on a surface opposite to the supporting plate and projects toward opposite to the supporting plate; a male screw that is fixed to the supporting plate so that a first end projects from the first surface to pass through the substrate, and a second end opposite to the first end does not project from a second surface opposite to the first surface of the supporting plate; and a female screw that is screwed with the first end of the male screw projecting from the substrate.
    Type: Grant
    Filed: May 16, 2016
    Date of Patent: June 9, 2020
    Assignee: Japan Display Inc.
    Inventor: Yuichi Tsubaki
  • Patent number: 10641772
    Abstract: The present disclosure provides methods, device, assemblies, and systems for dispensing and visualizing single cells. For example, provided herein are systems and methods for dispensing a dispense volume into a plurality of wells of a multi-well device, where, on average, a pre-determined number of cells (e.g., 1-20) are present in the dispense volume, and determining, via a cellular label, the number of cells present in each of the plurality of wells. Such dispensing and cell detection may be repeated a number of times with respect to wells identified as having less than the pre-determined number of cells in order increase the number wells in the multi-well device containing the desired number (e.g., a single cell).
    Type: Grant
    Filed: February 20, 2016
    Date of Patent: May 5, 2020
    Assignee: TAKARA BIO USA, INC.
    Inventors: Alain-Albert Mir, Thomas D. Schaal, Chun-Wah Lin, Shanavaz Loharasp D. Nasarabadi, Jude Dunne, Maithreyan Srinivasan, Patricio Espinoza
  • Patent number: 10627418
    Abstract: Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.
    Type: Grant
    Filed: May 23, 2016
    Date of Patent: April 21, 2020
    Assignee: Theranos IP Company, LLC
    Inventors: James Wasson, Pey-Jiun Ko, Joy Roy, Elizabeth A. Holmes
  • Patent number: 10620203
    Abstract: The present invention relates to an leucocyte antigen mediated microfluidic assay and a microfluidic device for analyzing a subjects' body fluids containing leucocytes to determine if the subject has been previously exposed to a predetermined antigen.
    Type: Grant
    Filed: April 6, 2015
    Date of Patent: April 14, 2020
    Assignee: Advanced Animal Diagnostics, Inc.
    Inventors: Rodolfo R. Rodriguez, Douglas J. Darr
  • Patent number: 10613106
    Abstract: Disclosed is a reaction vessel handling apparatus adapted for use in a biological fluid testing apparatus. The reaction vessel handling apparatus includes an incubation member and wash member that are overlapping. A transfer device transfers reaction vessels between the incubation member and wash member at the overlapping portions. Incubation and wash members may be rings. Testing apparatus (e.g., immunoassay apparatus or clinical analyzer apparatus) including the reaction vessel handling apparatus and methods of operating the apparatus are provided, as are other aspects.
    Type: Grant
    Filed: April 15, 2015
    Date of Patent: April 7, 2020
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Beri Cohen, Nicolae Dumitrescu
  • Patent number: 10593513
    Abstract: An examination container includes a main body, a membrane assembly and a cover. The main body has an accommodating trough for holding sample. The membrane assembly covers an opening end of the accommodating trough. The membrane assembly includes a support body and a membrane. The support body has a first surface and a second surface, wherein the support body is flat and has a first through-hole penetrating through the first surface and the second surface. The membrane is arranged on the second surface side of the support body and has a second through-hole. The second through-hole is opposite to the first through-hole and allows a charged particle beam to pass the second through-hole. The cover is detachably connected to the main body to secure the membrane assembly. The membrane assembly is easy to replace and uses less consumables. An electron microscope using the abovementioned examination container is also disclosed.
    Type: Grant
    Filed: July 18, 2018
    Date of Patent: March 17, 2020
    Assignee: TAIWAN ELECTRON MICROSCOPE INSTRUMENT CORPORATION
    Inventors: Tsu-Wei Huang, Jia-Ling Wu, Shih-Yi Liu, Maochan Chang
  • Patent number: 10557862
    Abstract: The present invention relates to systems and methods of determining quality compliance for a set of biological sample testing devices used with one or more test instruments at the point-of-care in a hospital or other location that delivers medical care. In particular, the systems and methods ensure that only biological sample testing devices that pass a quality assurance protocol are used for point-of-care testing.
    Type: Grant
    Filed: May 4, 2016
    Date of Patent: February 11, 2020
    Assignee: Abbott Point of Care Inc.
    Inventors: Paul Glavina, Jody Ann Tirinato
  • Patent number: 10557863
    Abstract: Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.
    Type: Grant
    Filed: July 1, 2015
    Date of Patent: February 11, 2020
    Assignee: Theranos IP Company, LLC
    Inventors: Elizabeth A. Holmes, Michael Chen, John K. Frankovich, Samartha Anekal, Adrit Lath, Alexander Loo, Chinmay Pangarkar, Joy Roy, Timothy Smith, Daniel Young
  • Patent number: 10532360
    Abstract: The system for management of rack and tube positions for clinical chemistry laboratories includes tubes (10) capable of containing human biological material, a rack (20) configured for receiving and/or holding the tubes (10) to be stocked, a supporting base (30) configured for supporting the rack (20) thereon, a reader (50) configured for reading an identifier (RID) of the rack (20) to be put onto the supporting base (30) and an identifier (TID) of the tube to be put into the rack (20), a camera (40) for detecting the rack (20) on the supporting base (30), and at least one of the tubes (10) into the rack (20), a processing unit (60) for mapping the detected rack (20) into a plurality of allowed positions (Pi) and the detected tube (10) into a tube position (P) included in the plurality of allowed positions (Pi).
    Type: Grant
    Filed: September 28, 2012
    Date of Patent: January 14, 2020
    Assignee: OMNILAB TECHNOLOGIES S.R.L.
    Inventors: Luca Birolini, Christian Otto
  • Patent number: 10512915
    Abstract: A nucleic acid amplifier comprises a holder 3 which is provided with a plurality of temperature control blocks 10 each designed to hold at least one reaction vessel 105 storing a reaction solution. The temperature of the reaction solution in each reaction vessel 105 is controlled individually by using temperature control devices 14 and 15 arranged in each of the temperature control blocks 10. The temperature that is set in each temperature control block 10 and the timing for temperature changes are controlled independently of the temperatures of other temperature control blocks 10. This configuration makes it possible to provide a nucleic acid amplifier and a nucleic acid inspection device (employing the nucleic acid amplifier) capable of processing multiple types of samples differing in the protocol in parallel (parallel processing) and starting a process for a different sample even when there is a process in execution.
    Type: Grant
    Filed: April 28, 2011
    Date of Patent: December 24, 2019
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Minoru Sano, Yoshiyuki Shoji, Masato Ishizawa, Kimikazu Sugiyama
  • Patent number: 10493457
    Abstract: A sample storage including a frame and an array of sample container holding areas disposed within the frame where a spacing between adjacent sample container holding areas is independent of a gripping area for sample containers held by the sample storage.
    Type: Grant
    Filed: March 27, 2015
    Date of Patent: December 3, 2019
    Assignee: Brooks Automation, Inc.
    Inventors: Etienne Croquette, Rhett Affleck, Robin Grimwood
  • Patent number: 10466263
    Abstract: The invention is in the field of automatic analysis devices and relates to a heatable pipetting device for an automatic analysis device and a method for providing a reaction mixture. The pipetting device comprises a pipetting needle having two temperature sensors at different distances to the tip of the pipetting needle.
    Type: Grant
    Filed: August 5, 2016
    Date of Patent: November 5, 2019
    Assignee: Siemens Healthcare Diagnostics Products Gmbh
    Inventor: Christian Verhalen
  • Patent number: 10458999
    Abstract: Provided is a cell suction system that supports suction work of a substance within a cell. The cell suction system includes: a suction section including a tubular tip configured to suction the substance from the inside of the cell received in a container; a detection section configured to acquire information on a front end part of the tip; and a conveyance section configured to make the suction section three-dimensionally movable, the conveyance section being configured to move the suction section to guide the front end part of the tip attached to the suction section into one specific cell based on the information obtained in the detection section.
    Type: Grant
    Filed: December 4, 2015
    Date of Patent: October 29, 2019
    Assignee: Yokogawa Electric Corporation
    Inventors: Takayuki Kei, Takuya Azuma, Hironori Takai
  • Patent number: 10452035
    Abstract: The invention relates to a configuration control device for a laboratory instrument, a laboratory instrument with a configuration control device for instrument-controlled treatment of at least one laboratory sample and a method for configuring the laboratory instrument by means of the configuration control device. By using user-dependent configuration data, the requirement for the user of having to perform a completely manual configuration of the laboratory instrument, which is effected by the user-dependent configuration data, is dispensed with.
    Type: Grant
    Filed: October 7, 2014
    Date of Patent: October 22, 2019
    Inventors: Wolfgang Goemann-Thoss, Wolf Wente, Andreas Thieme, Jan-Gerd Frerichs, Christiane Markau, Jan-Hendrik Hacker
  • Patent number: 10450144
    Abstract: The present invention is directed to a system and method for transferring specimen containers between detection instruments. The method may include transporting a specimen container in a locator well to a container transfer station in a first automated detection apparatus; sensing the specimen container at the container transfer station using a first sensor; transferring the specimen container from the container transfer station of the first automated microbial detection apparatus to an automated loading mechanism of a second automated microbial detection apparatus; detecting that the specimen container is positioned over the automated loading mechanism of the second automated microbial detection apparatus using a second sensor; and releasing the specimen container onto the automated loading mechanism of the second automated microbial detection apparatus.
    Type: Grant
    Filed: May 26, 2017
    Date of Patent: October 22, 2019
    Assignee: bioMerieux, Inc.
    Inventors: Thierry Vivet, Michael Belgeri, Walter Clynes
  • Patent number: 10441266
    Abstract: A method of treating a heart of a patient is provided, including implanting a first tissue anchor in cardiac tissue of the patient, the first tissue anchor attached to one or more tethers that are fixed to a coupling element. A second tissue anchor is implanted in the patient. The coupling element is coupled to a first coupling site of the second tissue anchor, thereby coupling the first tissue anchor to the second tissue anchor via the one or more tethers. Thereafter, after allowing at least 24 hours for tissue growth on the first tissue anchor to strengthen anchoring of the first tissue anchor in the cardiac tissue, tension is increased between the first and the second tissue anchors by decoupling the coupling element from the first coupling site and coupling the coupling element to a second coupling site of the second tissue anchor. Other embodiments are also described.
    Type: Grant
    Filed: February 23, 2018
    Date of Patent: October 15, 2019
    Assignee: 4Tech Inc.
    Inventors: Paolo Denti, Andrea Guidotti, Kevin Lynn, Idan Tobis
  • Patent number: 10429403
    Abstract: A head device for mounting a dispensing tip includes a piston member, a first shaft member to move the piston member in an up-down direction, a tubular rod including a tubular space having a cylinder space in which the piston member is housed to move in the up-down direction and including a tip mounting portion into which a base end portion of the dispensing tip is fitted, a first frame equipped with the first shaft member and the tubular rod, a second shaft member engaging with the first frame to move the first frame, a second frame equipped with the second shaft member and including a guide portion configured to guide movement of the tubular rod in the up-down direction in association with the movement of the first frame in the up-down direction, and a shaft controller configured to control operation of the first and second shaft members.
    Type: Grant
    Filed: June 17, 2014
    Date of Patent: October 1, 2019
    Assignee: YAMAHA HATSUDOKI KABUSHIKI KAISHA
    Inventors: Saburo Ito, Yukimasa Osada, Yohei Izume
  • Patent number: 10416136
    Abstract: A controlling apparatus 110 to control an operation of an analyzing apparatus 1 and make the analyzing apparatus 1 execute a predetermined analysis, the controlling apparatus 110 including: a communicating module 60 that maintains reception of electricity when the analyzing apparatus 1 is in a power-on state, and is capable of receiving a control signal from an external apparatus 2 at all times; and a unit power controlling section 23 for acquiring the control signal through the communicating module 60, stopping electricity supply to a unit 31, 321, 322, 323 and/or 324 of the analyzing apparatus 1 at a first timing based on the control signal, and restarting the electricity supply to the unit 31, 321, 322, 323 and/or 324 at a second timing based on the control signal, so as to effectively suppress the electricity consumption when the analysis is not executed and facilitate the restart of the analysis.
    Type: Grant
    Filed: June 24, 2014
    Date of Patent: September 17, 2019
    Assignee: SHIMADZU CORPORATION
    Inventors: Shinji Kanazawa, Fuyuki Okamoto
  • Patent number: 10401275
    Abstract: The invention relates to an analysis method for supporting classification, a determination method for determining analysis parameters Ys, Ei, Ii, ?i for the analysis method, a computer program product, and an optical analysis system for supporting classification, with which system analysis parameters Ys, Ei, Ii, ?i can be defined on the basis of first and second calibration data. The parameters provide classification support according to the discriminant analysis and on the basis of measured values Pi of optical characteristics i, in particular of organic dispersions, and the information content thereof for classification, in particular the diagnosis of disease; and permit a classification proposal or a diagnosis proposal in comparison with a threshold Ys.
    Type: Grant
    Filed: August 5, 2014
    Date of Patent: September 3, 2019
    Assignee: Siemens Healthcare Diagnostics Products GmbH
    Inventors: Barbara Kavsek, Peter Lederer, Peter Taal, Jan van den Boogaart
  • Patent number: 10401350
    Abstract: A sample analyzer prepares a measurement sample from a blood sample or a body fluid sample which differs from the blood sample; measures the prepared measurement sample; obtains characteristic information representing characteristics of the components in the measurement sample; sets either a blood measurement mode for measuring the blood sample, or a body fluid measurement mode for measuring the body fluid sample as an operating mode; and measures the measurement sample prepared from the blood sample by executing operations in the blood measurement mode when the blood measurement mode has been set, and measuring the measurement sample prepared from the body fluid sample by executing operations in the body fluid measurement mode that differs from the operations in the blood measurement mode when the body fluid measurement mode has been set, is disclosed. A computer program product is also disclosed.
    Type: Grant
    Filed: December 10, 2018
    Date of Patent: September 3, 2019
    Assignees: Sysmex Corporation, Sysmex America, Inc.
    Inventors: Takaaki Nagai, Noriyuki Narisada, Daigo Fukuma, Masanori Imazu
  • Patent number: 10386380
    Abstract: A sample processing system is configured for analyzing, preprocessing, or carrying out other operations for a biological sample such as blood or urea. With the sample processing system, it is possible to store samples to be stored in a thermally insulated state or specimens required for accuracy control in the thermally insulated state for preventing evaporation or denaturing of the samples and specimens. Also it is possible to carry in or out the samples, rack by rack, according to necessity. Further, the sample processing system is provided with a buffer unit in a cold container having a capability for cold storage and also by accessing a sample rack at random for carrying in or out a rack with a transfer mechanism provided outside of the cold container.
    Type: Grant
    Filed: December 5, 2017
    Date of Patent: August 20, 2019
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Kuniaki Onizawa, Koichi Obari, Junichi Oizumi, Shigemi Oba, Tetsuaki Abe
  • Patent number: 10381463
    Abstract: Embodiments are directed to a method and resulting structures for smoothing the sidewall roughness of a post-etched film. A sacrificial layer is formed on a substrate. A patterned mask is formed by removing portions of the sacrificial layer to expose a surface of the substrate. The sidewalls of the patterned mask are smoothed and a target layer is formed over the patterned mask and the substrate. Portions of the target layer are removed to expose a surface of the patterned mask and the patterned mask is removed.
    Type: Grant
    Filed: January 19, 2018
    Date of Patent: August 13, 2019
    Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Kafai Lai, Hari V. Mallela, Hiroyuki Miyazoe, Reinaldo A. Vega, Rajasekhar Venigalla
  • Patent number: 10359443
    Abstract: An automatic fecal occult blood detecting analyzer used to detect a sample box is provided. The analyzer has a feeding chain and a main conveying chain. A plurality of clamping devices for clamping the sample box are provided on the feeding chain and the main conveying chain, respectively. A transferring device of the analyzer transfers the sample box from the feeding chain to the main conveying chain. The analyzer also has a pressing device and an image acquisition device for acquiring tape information presented on test strips of the sample box on the main conveying chain. Continuous detection and accurate location of a plurality of the sample boxes can be implemented without turning over and tilting the sample boxes.
    Type: Grant
    Filed: December 24, 2015
    Date of Patent: July 23, 2019
    Assignee: W.H.P.M. BIORESEARCH AND TECHNOLOGY CO., LTD.
    Inventors: John Wan, Chunhai Zou, Qinghai Xia, Jie Liu
  • Patent number: 10351843
    Abstract: The present invention relates to an automated analytical system and an automated method for separating and detecting an analyte, as well as an automated analytical instrument.
    Type: Grant
    Filed: December 22, 2015
    Date of Patent: July 16, 2019
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Renato Belz, Andreas Gisler, Robert Huesler, Rolf Knobel, Christian Thalmann
  • Patent number: 10330692
    Abstract: The purpose of the present invention is to provide an automatic analysis device that combines a biochemical analysis unit and a blood coagulation analysis unit and has a high processing capacity while reducing device cost and life-cycle cost. An automatic analysis device is characterized in that when a synthetic-substrate item or latex-agglutination item from among synthetic-substrate, latex-agglutination, and clotting-time blood-coagulation-test items is made to be a first test item and the clotting-time item is made to be a second test item, if there is a measurement request for the first test item and second test item in the same specimen rack, a control unit determines the conveyance path of the specimen rack such that the first test item is measured using a biochemical analysis unit and the second test item is measured using a coagulation time analysis unit and controls a conveyance line.
    Type: Grant
    Filed: November 5, 2014
    Date of Patent: June 25, 2019
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Akihisa Makino, Chie Yabutani, Masato Ishizawa
  • Patent number: 10330691
    Abstract: A diagnostic analyzer includes a track, a light-blocking member, a motor, and an optical testing device. The track moves a reaction vessel held by the track. The light-blocking member is disposed adjacent to the track. The light-blocking member moves from a first position apart from the track to a second position closer to the track. When the light-blocking member is disposed in the first position a sample contained within the reaction vessel held by the track is exposed to light. When the light-blocking member is disposed in the second position the sample contained within the reaction vessel held by the track is blocked from exposure to the light. The motor moves the light-blocking member between the first and the second positions. The optical testing device is disposed adjacent to the track for optically testing the sample contained within the reaction vessel held by the track when the at least one light-blocking member is disposed in the second position.
    Type: Grant
    Filed: October 31, 2016
    Date of Patent: June 25, 2019
    Assignee: ABBOTT LABORATORIES
    Inventors: Joseph P. Donohue, Ryan Patrick Johnson
  • Patent number: 10286394
    Abstract: Provided are an analysis chip and a sample analysis device by which it is possible to perform analysis rapidly and accurately on a plurality of items simultaneously using a small amount of liquid for measurement. An analysis chip (10) is provided with: a substrate (20) formed in a substantially disc shape; an insertion hole (22) formed in the center of the substrate (20), a liquid to be measured being inserted into the insertion hole (22); and micro-flow paths (23) into which the liquid to be measured can be guided from the insertion hole (22) by capillary action, each of the micro-flow paths (23) having therein a plurality of types of antigens (30) that are fixed in place with gaps therebetween, the antigens (30) selectively reacting to components in the liquid to be measured.
    Type: Grant
    Filed: May 12, 2015
    Date of Patent: May 14, 2019
    Assignee: Takano Co., Ltd.
    Inventors: Kazutaka Hori, Tamotsu Minegishi, Shinya Yamamoto, Takamitsu Godo
  • Patent number: 10267815
    Abstract: A device for positioning vessels, with a holder for vessels, comprising a series of receptacles arranged on a circular line, for a circular ring-shaped vessel chain, a central area, arranged within the series of receptacles, and having further receptacles for single vessels containing reagents, and means for aligning, and with a carrier for single vessels, which comprises a holding plate in the form of a circular disc or of a part of a circular disc, which has holes for single vessels at certain positions, and which has at least one further means for aligning the carrier to the means for aligning the holder in a certain position, wherein in this position, the holes are aligned to certain further receptacles, the remaining further receptacles are covered up by the holding plate, and single vessels filled with reaction liquid can be inserted into the holes and into the further receptacles aligned thereto.
    Type: Grant
    Filed: May 30, 2012
    Date of Patent: April 23, 2019
    Assignee: Eppendorf AG
    Inventors: Helmut Knofe, Jens-Peter Kroog, Judith Lucke
  • Patent number: 10261016
    Abstract: A specimen analyzing method and a specimen analyzing apparatus capable of measuring interference substances before analyzing a specimen. The method comprises a step for sucking the specimen stored in a specimen container (150) and sampling it in a first container (153), a step for optically measuring the specimen in the first container, a step for sampling the specimen in a second container (154) and preparing a specimen for measurement by mixing the specimen with a reagent in the second container, and a step for analyzing the specimen for measurement according to the results of the optical measurement of the specimen.
    Type: Grant
    Filed: March 15, 2016
    Date of Patent: April 16, 2019
    Assignee: SYSMEX CORPORATION
    Inventors: Norimasa Yamamoto, Takashi Yamato, Naohiko Matsuo, Satoshi Iguchi
  • Patent number: 10241123
    Abstract: Disclosed is a method of operating a laboratory instrument (100, 1000), wherein the laboratory instrument is configured for receiving a sample rack (112) with one or more sample tubes (126), wherein the laboratory instrument comprises a robotic head (106) for bringing a pipettor (108) into fluidic contact with the one or more sample tubes when the sample rack is in an operating position (122), wherein the robotic head is configured for loading the sample rack into the operating position, and wherein the method comprises the steps of: receiving (200) the sample rack by the laboratory instrument; and loading (202) the rack into the operating position using the robotic head.
    Type: Grant
    Filed: November 29, 2016
    Date of Patent: March 26, 2019
    Assignee: ROCHE MOLECULAR SYSTEMS, INC.
    Inventors: Kurt Barmettler, Andre Peter
  • Patent number: 10234472
    Abstract: Disclosed is an automatic analysis device in which a check item at a time of an analysis start can be set in accordance with a skill level of an operator, an analysis can be performed after the check item being displayed and confirmed, and erroneous measurement caused due to a missed check can be prevented. The check item such as checking the remaining quantity of a reagent or the like displayed in a check screen before the analysis start can be set for each type of operator, each day, each time. The set check item is configured to be displayed in a screen before the analysis start, and unless the operator confirms the check item, the analysis start is not allowed in principle. An automatic analysis device which can prevent erroneous measurement caused due to a missed check of the operator before the analysis start is realized.
    Type: Grant
    Filed: April 7, 2015
    Date of Patent: March 19, 2019
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Hirofumi Sasaki, Toshihide Hanawa, Tsuguhiko Satou, Yoshihiro Naitou
  • Patent number: 10234473
    Abstract: An analytical device for automated determining of a measured variable of a liquid sample comprises: a liquid storage, which includes one or more liquid containers for one or more liquids; a measuring cell for accommodating the liquid sample, especially a liquid sample, to which has been added one or more liquids from the liquid storage, and a measuring arrangement for providing one or more measurement signals correlated with the measured variable; an electronics unit, which includes a control unit for control of the analytical device and for determining the measured variable based on the measurement signals provided by the measuring arrangement; and a handling unit including a supply- and dosing, or metering, system for supplying and metering the liquid sample and liquids from the liquid storage into the measuring cell, wherein the analytical device includes at least one exchangeable cassette, into which are integrated at least parts of the liquid storage and/or at least parts of the handling unit.
    Type: Grant
    Filed: August 17, 2010
    Date of Patent: March 19, 2019
    Assignee: Endress+Hauser Conducta GmbH+Co. KG
    Inventors: Ralf Steuerwald, Ulrich Kathe
  • Patent number: 10234364
    Abstract: First and second racks each has fixed positions to hold sample tubes. First and second drawers slide into and out of the case, and that support the first and second racks, respectively. A tube set unit is provided in an area close to the first rack in the case. A tube transfer unit removes sample tubes from the first and second racks in the case and a controller that controls a transfer operation of the tube transfer unit. The first rack is supported by the first drawer such that the first rack leaves a transit location in the case behind the first drawer in the direction of the first drawer movement into the case. The controller controls the tube transfer unit to remove at least one sample tube from the second rack and transfers the tube to the tube set unit via a path traversing the transit location.
    Type: Grant
    Filed: June 29, 2017
    Date of Patent: March 19, 2019
    Assignee: SYSMEX CORPORATION
    Inventors: Takaaki Nagai, Daigo Fukuma, Mitsuo Yamasaki, Noriyuki Nakanishi, Syunsuke Yao, Tomonori Okazaki, Takahiro Saino
  • Patent number: 10227287
    Abstract: Described is a method of detecting and/or determining levels of incorporation of monolignol ferulate conjugate esters into lignin by derivatizing the lignin, reductively cleaving the lignin, labeling the cleavage products, and then detecting cleavage products derived from monolignol ester conjugates via differential attachment of the label.
    Type: Grant
    Filed: December 31, 2015
    Date of Patent: March 12, 2019
    Assignee: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: John Ralph, Steven D Karlen, Fachuang Lu, Dharshana Padmakshan
  • Patent number: 10220360
    Abstract: During the use of a liquid mixing apparatus, a liquid container can be installed onto an adapter. The liquid container drives a lifting assembly to allow a piercing assembly to pierce through the adapter. Once a fluid flows into a flowing passage portion via a fluid inlet, a portion of the fluid is pressurized via a branch passage portion with easy control and further flows into the liquid container to mix with a fragrance material inside the liquid container. The mixed fragrant liquid then flows out of a fluid outlet from the piercing assembly via the return passage portion and the flowing passage portion. With the pressurization design of the branch passage portion, the apparatus allows the increase of dimension to increase the flow rate while maintaining the pressurized liquid, which is convenient to use and facilitated for the control of the mixture amount with greater variation range.
    Type: Grant
    Filed: August 9, 2017
    Date of Patent: March 5, 2019
    Assignee: AROTEC CORPORATION
    Inventors: Ching-Hua Wang, Yu-Wen Yen
  • Patent number: 10215647
    Abstract: Methods and systems accurately determine an analyte concentration in a fluid sample. In an example embodiment, a receiving port receives a test sensor. The test sensor includes a fluid-receiving area for receiving a fluid sample. The fluid-receiving area contains a reagent that produces a measurable reaction with an analyte in the fluid sample. The test sensor has a test-sensor temperature and the reagent has a reagent temperature. A measurement system measures the reaction between the reagent and the analyte. A temperature-measuring system measures the test sensor temperature when the test sensor is received into the receiving port. A concentration of the analyte in the fluid sample is determined according to the measurement of the reaction and the measurement of the test sensor temperature. A diagnostic system determines an accuracy of the temperature-measuring system. The calculation of the analyte concentration may be adjusted according to the accuracy of temperature-measuring system.
    Type: Grant
    Filed: December 14, 2017
    Date of Patent: February 26, 2019
    Assignee: ASCENSIA DIABETES CARE HOLDINGS AG
    Inventors: Narasinha Parasnis, Hoi-Cheong Steve Sun, Mu Wu
  • Patent number: 10196955
    Abstract: A method includes determining whether a urea refill event is detected, and clearing a quality accumulator value and clearing a latching abort command. The method includes determining whether urea fluid quality check abort conditions are met, and clearing the urea quality accumulator, latching the abort command, and exiting the reductant fluid quality check. In response to the abort conditions not being met, incrementing the urea quality accumulator according to an amount of urea being injected, and comparing the accumulated urea quantity to a low test threshold. The method includes, in response to the accumulated urea quantity being greater than the low test threshold, comparing the accumulated urea quantity to a high test threshold, and in response to the urea quantity being greater than the high test threshold, determining whether the a NOx exceedance is observed and clearing a urea quality error in response to the NOx exceedance not being observed.
    Type: Grant
    Filed: June 8, 2016
    Date of Patent: February 5, 2019
    Assignee: Cummins Emission Solutions Inc.
    Inventors: Xi Wei, David Samuel Everard, Baohua Qi, Mickey R. McDaniel, Edmund P. Hodzen, Guoquian Li
  • Patent number: 10192637
    Abstract: This specimen analyzer includes: an analysis unit which analyzes a specimen collected from a subject; a print unit which prints on a print sheet; a display unit which displays an operation screen; and a controller which performs control of causing the print unit to print an analysis result of the analysis unit, and prohibiting the display unit from displaying the analysis result.
    Type: Grant
    Filed: May 31, 2017
    Date of Patent: January 29, 2019
    Assignee: SYSMEX CORPORATION
    Inventors: Seiji Takemoto, Takeshi Komoto, Hideki Hirayama, Takashi Yoshida, James Ausdenmoore
  • Patent number: 10184948
    Abstract: An automated analyzer maintains high processing capacity and dispensation accuracy even when items requiring dilution/pretreatment and general reaction measurement are mixed. A plurality of sample dispensing mechanisms are independently driven and each include a sample collection position, a sample nozzle for collecting the sample, and a washing tank for washing the sample nozzle. The sample dispensing mechanisms are configured to collect the sample from a plurality of sample collection positions and are operated independently to perform sample dispensation into reaction containers on a reaction disc. At least one of the sample dispensing mechanisms is provided for each of a sample requiring dilution/pretreatment and a sample that does not require dilution/pretreatment. The automated analyzer is provided with a control means for causing the respective mechanisms to be operated in a dedicated manner. The sample is dispensed such that no vacancy is created in the reaction containers.
    Type: Grant
    Filed: August 24, 2016
    Date of Patent: January 22, 2019
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Akihiro Yasui, Yoshihiro Suzuki, Hitoshi Tokieda
  • Patent number: 10184104
    Abstract: The present invention provides a self-draining well plate cassette and an automated system for cultivating C. elegans comprising a housing, a well plate assembly having at least two of the self-draining well plate cassettes, a liquid dispensing assembly operated by a first three axes positioner, a wash and imaging assembly operated by a second three axis positioner, a reagent assembly, a pipette tip holder, and a controller. The present invention further provides a method of using the above-described system to cultivate C. elegans.
    Type: Grant
    Filed: October 12, 2016
    Date of Patent: January 22, 2019
    Inventors: Alexander Lee Lianides, Christopher Lee Lianides
  • Patent number: 10168345
    Abstract: An automatic analysis apparatus capable of improving detection sensitivity is provided. An optimum photometer between a light-scattering photometer and an absorptiometer based on a concentration range may be decided. A standard solution is measured multiple times at a normal calibration and a calibration curve is created. Calibration curves are individually created for an absorptiometer and a light-scattering photometer from the minimum and maximum measured values of the concentrations of each standard solution. The upper and lower limits of a standard solution concentration are computed from the minimum/maximum calibration curves. Sensitivity may be computed by using calibration parameters. Whether to use a concentration by absorption or a concentration by scattered light is decided based on the computed sensitivity. The computed sensitivities are compared between the concentration by absorption and the concentration by scattered light, and the use of the concentration of a higher sensitivity is decided.
    Type: Grant
    Filed: May 30, 2013
    Date of Patent: January 1, 2019
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Akiko Yokokawa, Tomonori Mimura, Sakuichiro Adachi
  • Patent number: 10151673
    Abstract: A treatment device (1) for treating histological or cytological samples has a plurality of containers (6) for different treatment agents and a detection apparatus (2) for detecting a code which unequivocally identifies a type of a treatment agent or a type of a group of treatment agents from a package or replacement container of a treatment agent or group of treatment agents. The device furthermore has an evaluation apparatus (18) that, based on a detected code, ascertains which of the containers is or are to be replenished or replaced, and an indicating apparatus (4) which communicates to a user the ascertained container (6) or containers (6) that is or are to be replenished or replaced. The indicating apparatus may include a display (5) presenting a schematic image of the plurality of containers (6) with image(s) of each ascertained container being marked, and/or a light source (15) that illuminates each ascertained container.
    Type: Grant
    Filed: June 22, 2017
    Date of Patent: December 11, 2018
    Assignee: Leica Biosystems Nussloch GmbH
    Inventors: Bernhard Neef, Markus Wittmann
  • Patent number: 10151765
    Abstract: A method for processing sample tubes comprising biological samples is presented. The method comprises transporting a sample tube closed by a closure to a first work cell, removing the closure with a first decapping/recapping device; withdrawing from the sample tube a sample aliquot with a pipetting unit for processing by the first work cell and/or dispensing liquid into the sample tube and/or determining a sample parameter with an analytical unit, reclosing the sample tube with a closure with the first decapping/recapping device, transporting the sample tube to a second work cell, removing the closure with a second decapping/recapping device, and withdrawing from the sample tube a sample aliquot with a pipetting unit for processing by the second work cell and/or dispensing a volume of liquid into the sample tube and/or determining a sample parameter of the sample with of an analytical unit.
    Type: Grant
    Filed: June 16, 2016
    Date of Patent: December 11, 2018
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Dietmar Kappelhoff, Gottlieb Schacher
  • Patent number: 10139422
    Abstract: Methods and systems for performing tests in an in vitro diagnostic environment provide for a substantially optimized distribution of testing reagents amongst a plurality of analyzers. The system and method can include steps of identifying a plurality of expected tests to be performed by a plurality of analyzer modules, determining information about the capabilities of the plurality of analyzer modules, and receiving, at the processor, data reflecting which of the plurality of tests are incompatible. Further steps can include calculating a substantially optimal distribution of the plurality of expected tests amongst the plurality of analyzer modules, allocating reagents to each of the plurality of analyzer modules by facilitating distribution of a plurality of reagents to selected analyzer modules in response to the step of calculating, and automatically scheduling a plurality of samples to undergo tests at the plurality of analyzer modules.
    Type: Grant
    Filed: January 9, 2014
    Date of Patent: November 27, 2018
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Benjamin S. Pollack, Colin Mellars, Baris Yagci
  • Patent number: 10106769
    Abstract: An automatic culturing device configured such that, in a work chamber 2a maintained in a sterile state, first and second robots 6 and 7 are arranged so that the movable ranges thereof partially overlap each other, and such that liquid supply means 10 which supplies liquids, containing a culture medium and liquid medicine, to containers held by the robots, and temporary placement sections (handing-over table 42, centrifuge tube holder 43, and heated room 44), each of which hands over the containers between the first and second robots, are provided in the movable ranges of the first and second robots, which ranges overlap each other. The first robot takes out the containers housed in housing means (rotary stocker 8), and the second robot holds and transports the containers handed over from the first robot via the temporary placement section. The cultivating operation can be efficiently performed.
    Type: Grant
    Filed: June 12, 2015
    Date of Patent: October 23, 2018
    Assignee: SHIBUYA CORPORATION
    Inventors: Masahiro Sakamoto, Noriaki Nishimura
  • Patent number: 10107806
    Abstract: The apparatus has a containing body with a flat upper functional floor for containing receptacles of reagents, diluents and samples, as well as housings for gel cards and incubators for the same; a lower floor containing receptacles for washing liquids and the collection of waste and cards and for housing the fluid control and electronic control system; a series of longitudinal and transverse guides associated with the upper part of the apparatus, suitable for carrying in suspension the moving heads of the apparatus, the heads being movable on the transverse guides; two heads, respectively for perforation and pipetting and for the transport of gel cards; two centrifuges and a gel card reader; and a folding touch screen providing information and control.
    Type: Grant
    Filed: May 6, 2016
    Date of Patent: October 23, 2018
    Assignee: GRIFOLS, S.A.
    Inventors: Enrique Martinell Gispert-Sauch, Jordi Puig Cebria