Sample Mechanical Transport Means In Or For Automated Analytical System Patents (Class 422/63)
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Patent number: 12370552Abstract: A method for fluid handling that includes reading information about a receptacle holder with an RFID reader and transmitting the information from an RFID transponder disposed on a first body of the receptacle holder that supports a fluid-containing receptacle. This information is used to align a robotic fluid transfer device with the first fluid-containing receptacle. Detecting a change in capacitance between an electrically conductive probe of the robotic fluid transfer device and an electrical ground or voltage source capacitively coupled to fluid contained in the first fluid-containing receptacle is an indication that the probe has contacted the fluid contained in the first fluid-containing receptacle. Once it is determined that the probe has contacted the fluid, the fluid transfer device aspirates a portion of the fluid contained in the first fluid-containing receptacle.Type: GrantFiled: August 2, 2023Date of Patent: July 29, 2025Assignee: GEN-PROBE INCORPORATEDInventors: Trung Pham, Jerry W. Jeffers, II, David Buse, Steven G. Grubbs
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Patent number: 12368038Abstract: Systems and methods are described to concentrate and homogenize a remote sample for analysis. A sample concentration and homogenization system embodiment includes, but is not limited to, at least a first valve, at least a first column fluidically coupled to the first valve, a flow meter fluidically coupled with the first column when the first valve is in a first flow path configuration to measure an amount of the liquid sample passed through the first column, and a homogenization valve including a sample homogenizing loop in which the concentrated sample is homogenized.Type: GrantFiled: September 26, 2023Date of Patent: July 22, 2025Assignee: Elemental Scientific, Inc.Inventor: Austin Schultz
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Patent number: 12360133Abstract: A pipette-tip connecting device has a base, a first positioning mechanism, a second positioning mechanism, a connecting seat, a pipette-fixing seat, and a tilt actuator. The first positioning mechanism extends along a first direction. The second positioning mechanism is linked to the first slider and extending upward and downward along a second direction. The connecting seat is mounted on the second slider such that positions of the connecting seat along the first direction and the second direction are controlled by the first positioning mechanism and the second positioning mechanism respectively. The pipette-fixing seat is mounted on the connecting seat and is pivotal relative to the connecting seat. The pipette-fixing seat has a pipette-tip connector which moves in the first direction and the second direction when the pipette-fixing seat pivots. The tilt actuator controls a relative angle between the pipette-fixing seat and the connecting seat.Type: GrantFiled: November 1, 2021Date of Patent: July 15, 2025Assignee: DrSignal BioTechnology Co., Ltd.Inventors: Hsin Wu Mi, Hsin Fei Huang
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Patent number: 12352772Abstract: There is provided a technique that can efficiently control disposal and use of containers of an automatic analyzer. An automatic analyzer includes a controller, a container retaining mechanism (incubator), a dispensing mechanism, a detection mechanism, and a transfer mechanism. The dispensing mechanism includes a liquid surface detection mechanism. The controller uses the dispensing mechanism at a prescribed timing to detect the presence or absence of the liquid surface at a target position on the container retaining mechanism to determine a state including the presence or absence of the container accommodating a reaction solution. The controller performs control in which the operation of disposal using the transfer mechanism is performed at a position when a state is determined in which the container is present, and the operation of disposal using the transfer mechanism is not performed at the position when a state is determined in which the container is not present.Type: GrantFiled: January 22, 2020Date of Patent: July 8, 2025Assignee: Hitachi High-Tech CorporationInventor: Akira Joji
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Patent number: 12350679Abstract: A container includes a lower portion and a lid to connect with the lower portion. The lid includes a fluidic interface, a swing bar, and a counter structure disposed on an opposite side of the fluidic interface relative to the swing bar. The fluidic interface includes a first liquid port, a second liquid port, a gas port, and a seal ring disposed around the first liquid port, the second liquid port, and the gas port, the first liquid port disposed along a center axis of the container.Type: GrantFiled: February 9, 2024Date of Patent: July 8, 2025Assignee: Life Technologies CorporationInventors: Mark Reed, Rui Zheng
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Patent number: 12332998Abstract: A control method for an anomalous data sensing system including at least a plurality of authentication servers and including: sensing whether data obtained from a device is not anomalous; obtaining first transaction data including information indicating the data; verifying, by a first authentication server included in the plurality of authentication servers, the first transaction data obtained, when the data is sensed as not being anomalous; and recording a block including the first transaction data into a distributed ledger when an agreement about validity of the first transaction data is reached using a consensus algorithm.Type: GrantFiled: November 18, 2022Date of Patent: June 17, 2025Assignee: PANASONIC INTELLECTUAL PROPERTY CORPORATION OF AMERICAInventors: Yuji Unagami, Tomoyuki Haga, Kakuya Yamamoto, Ayaka Mitani
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Patent number: 12329192Abstract: Disclosed are systems and methods for automatic infusion of concentrate and distillate material into cigarettes or other containers. In one embodiment, a thermally-controlled infusion system is provided. The system can maintain a selected temperature of the concentrate material throughout the infusion process, using a two-stage approach. In a first stage, the concentrate material is pressure-fed to a dosing chamber. In the second stage, the concentrate material is pumped into an insertion canula and into a cigarette or container. A revolver houses the cigarettes or containers and vertically transitions them to an insertion position, where the insertion canula can infuse the cigarettes or containers.Type: GrantFiled: February 19, 2024Date of Patent: June 17, 2025Assignee: Sorting Robotics, Inc.Inventors: Nohtal Partansky, Paul Skaar
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Patent number: 12296330Abstract: An in-vitro diagnostic device including a pipetting unit and a pipetting method, which allow for a more reproducible and more precise pipetting of liquids, when piercing through a lid of a closed liquid container is required. The pipetting unit is controlled to repeat penetration of the lid of the closed liquid container if the pressure difference between the interior of the liquid container and the surrounding is outside an allowable predefined pressure range.Type: GrantFiled: November 17, 2020Date of Patent: May 13, 2025Assignee: ROCHE DIAGNOSTICS OPERATIONS, INC.Inventors: Ronald Egli, Mirko Klingauf, Daniel Ott, Jerome Wiss
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Patent number: 12270105Abstract: The present disclosure provides a gas injection system that can include a housing configured to hold a plurality of precursor cartridges comprising one or more precursor materials, and a nozzle extending from the housing, the nozzle having a tip configured for insertion into a sample chamber of a material processing apparatus. The precursor cartridges are fluidly connected to the nozzle to selectively deliver one or more precursor gasses to the sample chamber.Type: GrantFiled: January 14, 2022Date of Patent: April 8, 2025Assignee: MEO Engineering Company, Inc.Inventors: Alexander Groholski, Valery Ray, Joseph Favata
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Patent number: 12270823Abstract: There is provided an automated analysis device capable of transferring instruments to be used for an analysis process to a predetermined processing position efficiently and rapidly. In an automated analysis device of the invention, a transfer unit forming a transfer mechanism to transfer instruments to be used for analyte processing into an analyte processing space includes a holding portion to hold the instruments. The holding portion includes a first fitting attachment portion to be attachable to a first instrument in a fitted state, and a second fitting attachment portion to be attachable to a second instrument in a fitted state.Type: GrantFiled: December 23, 2021Date of Patent: April 8, 2025Assignee: SEKISUI MEDICAL CO., LTD.Inventors: Kyoichi Iwahashi, Yasuo Minami, Tomohide Asai, Seiichiro Ishioka
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Patent number: 12241826Abstract: An arithmetic expression used for estimating a target item of a specimen is more easily incorporated into an optical measurement system. An optical measurement instrument includes an optical analysis unit configured to perform an optical analysis on a specimen and measure an intensity of light as a result of the optical analysis, and an arithmetic processing unit configured to download an arithmetic expression from a server device via a network, and perform a quantitative analysis on a target substance contained in the specimen by substituting the result of the optical analysis by the optical analysis unit into the arithmetic expression.Type: GrantFiled: March 19, 2020Date of Patent: March 4, 2025Assignee: Hitachi, Ltd.Inventors: Takuya Kambayashi, Toshimitsu Noguchi, Shunsuke Kono, Akihiro Nojima
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Patent number: 12239061Abstract: Disclosed is a system for monitoring parts in a machine is provided. The system includes a base unit, and an electronic circuitry. The base unit includes a generator for generating controllable frequency, an impedance unit to resonate impedance with a matching frequency, a controller for modulating the impedance with commands, a first electrode to emit an alternating electric field, a mixer, and a communication unit for communicating the data and commands over a communication network. Further, the controller decodes changes in the impedance.Type: GrantFiled: April 8, 2022Date of Patent: March 4, 2025Inventors: Wolfgang Richter, Faranak Zadeh
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Patent number: 12235280Abstract: The invention provides an automatic analyzer capable of closing a lid of a container containing a reagent or a specimen without wearing an upper surface of the lid even when the lid fails to close. The automatic analyzer includes a container accommodation portion that has a lid openable and closable by a rotation fulcrum and accommodates a container containing a reagent or a specimen, and a lid closing guide portion that closes the lid by moving relative to the container accommodation portion, wherein the lid closing guide portion is in contact with an edge of the lid to close the lid.Type: GrantFiled: January 9, 2020Date of Patent: February 25, 2025Assignee: HITACHI HIGH-TECH CORPORATIONInventors: Daisuke Kanai, Koki Yokoyama, Takenori Okusa
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Patent number: 12233427Abstract: A centrifugal cleaner with a reject chamber (1) having a center dilution arrangement (3) with a dilution nozzle (4) to deliver dilution fluid to the reject chamber (1), and a reject outlet (7) at the bottom of the reject chamber (1). The dilution nozzle (4) points outwards to create a crossing outward flow of dilution fluid across an annular space (5) around the dilution arrangement (3) to slow circulating fluid flowing down from a cone (2) of the centrifugal cleaner to the reject chamber (1). The dilution arrangement (3) may have a clearing nozzle (6), directed against the reject outlet (7). The dilution nozzle (4) may be pointed below the bottom end (9) of the cone (2) and the dilution arrangement (3) may not extend higher than the bottom end of the cone.Type: GrantFiled: January 30, 2020Date of Patent: February 25, 2025Assignee: ANDRITZ OYInventors: Antti Nykänen, Miro Partty, Jason Huff
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Patent number: 12174098Abstract: A tissue piece treating apparatus including a treating tank; a plurality of storage containers in each of which a paraffin bottle for storing a paraffin is housed; a constant temperature rack that houses the storage containers, and heats the paraffin to hold the paraffin in a molten state; and a paraffin pipeline that branches from the treating tank, in which in the storage containers, a treatment container in which the paraffin to be transported to the treating tank is housed and a standby container in which the paraffin not to be transported to treating tank is housed, are disposed, and the paraffin pipeline is connected to the paraffin bottle to be housed in the treatment container.Type: GrantFiled: November 13, 2019Date of Patent: December 24, 2024Assignees: SAKURA SEIKI CO., LTD., SAKURA FINETEK JAPAN CO., LTD.Inventors: Tadashi Tofukuji, Takeshi Tsukada
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Patent number: 12173273Abstract: The present invention relates to a large-scale magnetic purification system, including: a liquid storage apparatus, capable of being connected to a liquid source and a waste liquid barrel through a liquid path system; a stirring system mounted above the liquid storage apparatus, where a stirring paddle of the stirring system is inserted into the liquid storage apparatus for stirring; magnets mounted around the liquid storage apparatus; a magnet actuating mechanism for manipulating the magnets to move away from or close to the liquid storage apparatus; and a control system, connected to the liquid path system, the magnet actuating mechanism, and the stirring system and controlling the liquid path system, the magnet actuating mechanism, and the stirring system.Type: GrantFiled: October 25, 2019Date of Patent: December 24, 2024Assignee: NANJING GENSCRIPT BIOTECH CO., LTD.Inventors: Guodong Chen, Zaidong Feng, Ruina He, Hong Qian, Tao Bai
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Patent number: 12169206Abstract: A method of handling laboratory sample containers is presented. The method comprises moving a laboratory sample container to a target position. The target position is a position at which the laboratory sample container is inserted into a corresponding orifice of a laboratory sample container rack provided that the laboratory sample container rack is placed at an intended position. The laboratory sample container is prevented from moving horizontally more than a predetermined horizontal distance if inserted into the corresponding orifice of the laboratory sample container rack. The method also comprises applying a force in a horizontal direction (xy) to the laboratory sample container, determining if the laboratory sample container moves in the horizontal direction (xy) more than the predetermined horizontal distance, and performing an error procedure if it is determined that the laboratory sample container moves in the horizontal direction (xy) more than the predetermined horizontal distance.Type: GrantFiled: October 10, 2019Date of Patent: December 17, 2024Assignee: Roche Diagnostics Operations, Inc.Inventors: Raul Baltasar Badaya, Julian Baumgart
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Patent number: 12163972Abstract: Proposed is a technique for facilitating work of cause investigation of a defect by an operator. The present disclosure proposes an automatic analyzer including: a reagent dispensing unit configured to aspirate a reagent from a reagent vessel that contains the reagent, and discharge the reagent into a reaction vessel that contains a reaction liquid containing a sample; a storage unit configured to store a type of the sample and concentration-related information determined for each type of the sample and related to a concentration of a component to be measured contained in the sample; a detection unit configured to detect a measurement concentration that is the concentration of the component to be measured contained in the reaction liquid; and a determination unit configured to determine whether an abnormality occurs in the reagent vessel based on the concentration-related information and the measurement concentration.Type: GrantFiled: March 3, 2020Date of Patent: December 10, 2024Assignee: Hitachi High-Tech CorporationInventors: Hirobumi Shiohata, Yuichiro Ota, Takaaki Hagiwara
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Patent number: 12140510Abstract: Various implementations include a device for analyzing total organic carbon (TOC) within a fluid. The device includes a primary container, an input conduit, and an output conduit. The primary container is hollow and has a primary side wall and a primary end wall. The primary side wall has an inner surface defining a primary cavity and an outer surface opposite and spaced apart from the inner surface. The primary end wall includes a septum that is resiliently penetrable by an analyzer needle of a grab analysis port of a TOC analyzer. The input conduit has an input lumen. The input conduit extends through the primary container such that the input lumen is in fluid communication with the primary cavity. The output conduit has an output lumen.Type: GrantFiled: June 26, 2019Date of Patent: November 12, 2024Assignee: BL TECHNOLOGIES, INC.Inventor: Lukas Swanson
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Patent number: 12121891Abstract: Described herein are systems and methods used for washing needle assemblies with multiple needles.Type: GrantFiled: August 16, 2021Date of Patent: October 22, 2024Assignee: Waters Technologies CorporationInventors: Rose Solow, David A. Simpson, Colin F. Fredette, Marc E. Lemelin, Joshua A. Burnett
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Patent number: 12115531Abstract: A computerized device provides microscopy and electrochemistry tests, performed in dual channels. The device can be brought to the field, for on-site testing with instant results. The dual channels include an imaging channel and a signal channel.Type: GrantFiled: November 22, 2023Date of Patent: October 15, 2024Assignee: E.F.A. ENGINEERING FOR ALL LTD.Inventor: Yoel Ezra
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Patent number: 12105107Abstract: A jig assembly for connecting first and second consoles with predefined relative positioning includes first and second positioning pins attached or attachable to the first console and a positioning connection bracket attached or attachable to the second console and including a longitudinal span and first and second transverse legs including first and second pin recesses at respective free ends thereof. The first and second pin recesses receive the first and second positioning pins, respectively, when the first and second consoles are moved laterally toward each other. The first and second transverse legs may be attached to the first console with a first and second leg attachment brackets, respectively. The first and second positing pins and the first and second leg attachment brackets may be fixed with respect to the first console by attachment to a mounting rail that is fixed to the first console.Type: GrantFiled: January 18, 2023Date of Patent: October 1, 2024Assignee: GEN-PROBE INCORPORATEDInventors: Rolf Silbert, HongRan Peng
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Patent number: 12092560Abstract: A detection method according to one or more embodiments may include transporting a rack holding a reaction vessel along a first axis toward a sample dispensing position, linearly moving the sample dispensing pipette above the rack along a second axis intersecting the first axis and dispensing a sample into the reaction vessel located at the sample dispensing position, transporting the rack along the first axis toward a reagent dispensing position; linearly moving a reagent dispensing pipette above the rack along a third axis intersecting the first axis, and dispensing a reagent into the reaction vessel located at the reagent dispensing position, and detecting a detection target in a measurement specimen prepared from the sample and the reagent.Type: GrantFiled: November 29, 2021Date of Patent: September 17, 2024Assignee: SYSMEX CORPORATIONInventors: Masatsugu Ozasa, Daiki Fujiwara, Daiki Mita, Takaaki Okajima, Hideki Hirayama
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Patent number: 12085563Abstract: Described is a lateral flow high throughput assay device analyzer for preparing and analyzing a plurality of lateral flow assay samples. The analyzer comprises a cartridge stage for supporting an assay cartridge, an elevation adjustment mechanism, and a translation adjustment mechanism for aligning the cartridge stage and assay cartridge relative to a vertical support structure, fluid metering device, and detection device for high throughput lateral flow assay analysis.Type: GrantFiled: December 20, 2019Date of Patent: September 10, 2024Assignee: Kenota Inc.Inventors: Christopher J. Harder, David Andrew McMullin, Eric Blondeel, Kien Vu
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Patent number: 12085583Abstract: Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.Type: GrantFiled: May 13, 2021Date of Patent: September 10, 2024Assignee: Labrador Diagnostics LLCInventors: Elizabeth A. Holmes, Michael Chen, Pey-Jiun Ko
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Patent number: 12066448Abstract: An inspection result of a specimen inspection automation system can be reported within a prescribed time, even if a large number of urgent specimens have been input. An instruction reception unit receives turn around time (TAT) information and a discharge instruction. The necessity of discharging a specimen for which the instruction was issued with the discharge instruction is determined and a discharge instruction unit creates a discharge destination and a conveyance route to the discharge destination for the specimen. A discharge mechanism discharges the specimen for which the instruction was issued. Even for a specimen which is caused to wait for processing due to the occurrence of specimen congestion and for which there is a risk of an inspection result reporting delay, an inspection result can be reported within a prescribed time by switching from automatic processing by the system to manual processing by an operator.Type: GrantFiled: March 11, 2020Date of Patent: August 20, 2024Assignee: HITACHI HIGH-TECH CORPORATIONInventors: Satohiro Hamano, Shigeru Yano, Misato Fukami, Ai Masuda
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Patent number: 12066412Abstract: The present invention discloses a circulating multidimensional liquid chromatography and application thereof. The liquid chromatography comprises an infusion device, a sampling device, a collecting-resampling device, a chromatographic column switching device and a detecting device which are connected sequentially, wherein the collecting-resampling device comprises a collecting valve and a sample ring, and the collecting valve is connected with the sample ring; the sampling device is successively connected with the collecting valve and the chromatographic column switching device; the detecting device is also connected with the collecting valve; and the collecting valve is a three-slot three-position multi-way valve.Type: GrantFiled: August 27, 2023Date of Patent: August 20, 2024Assignee: SERICULTURE & AGRI-FOOD RESEARCH INSTITUTE GUANGDONG ACADEMY OF AGRICULTURAL SCIENCESInventors: Tiantian Zhao, Yajun Chen, Yehui Zhang, Yousheng Zhang, Wenjuan Jiao, Weifeng Liu, Fang Zhou
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Patent number: 12030712Abstract: A transport container includes: a bottom member where the transported object is placed; left and right side members disposed beside the bottom member; a handle disposed above the bottom member; left and right lower connecting members interconnecting the bottom member and side members; and left and right upper connecting members interconnecting the side and the handle members, which are respectively interconnected via hinges. When the handle is not lifted, the side members are separated from the bottom member. When the handle is lifted, the side members laterally support the transported object. As for the transport method, with the transported object stacked in the up-down direction, the transport container is installed at an unloading location such that the lower and upper connecting members are laid to be non-parallel to the side member, and the transported object is taken out from the front or rear between the left and right side members.Type: GrantFiled: July 1, 2020Date of Patent: July 9, 2024Assignee: HITACHI HIGH-TECH CORPORATIONInventors: Junpei Hokari, Tadao Yabuhara
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Patent number: 12031984Abstract: A detection device using a lateral flow strip for detection and a detection method thereof are provided, which relates to the technical field of a detection device using a lateral flow strip. An upper rotor, a middle rotor and a lower rotor are respectively provided with upper paddle(s), middle paddle(s) and lower paddle(s) along respective circumferential directions. Each upper paddle is provided with a test tube with openings at both ends thereof for placing the lateral flow strip. The middle paddle blocks a bottom one of the openings of the test tube. Each lower paddle is provided with a sample tube for placing sample solution. The bottom opening of the test tube is opposite to a top opening of the sample tube up and down.Type: GrantFiled: October 27, 2021Date of Patent: July 9, 2024Assignee: CHINA AGRICULTURAL UNIVERSITYInventors: Nan Cheng, Xiaoyun He, Wentao Xu, Kunlun Huang, Yunbo Luo, Qian Zhang, Qingliang Liu
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Patent number: 12025597Abstract: A liquid chromatograph includes a liquid sender that sends a plurality of solvents, a mixer that has an internal capacity for mixing the plurality of solvents sent by the liquid sender, a sample injector that injects a sample into an analysis flow path through which the solvents mixed in the mixer flow as a mobile phase, a separation column provided on the analysis flow path for separating the sample injected by the sample injector to each component, a detector provided downstream of the separation column on the analysis flow path for detecting the components of the sample separated in the separation column, a capacity information storage medium that is attached to the mixer to store information as to the internal capacity of the mixer, configured to read the information stored in the capacity information storage medium to specify the internal capacity of the mixer.Type: GrantFiled: October 15, 2019Date of Patent: July 2, 2024Assignee: SHIMADZU CORPORATIONInventor: Hiroshi Ohashi
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Patent number: 12013407Abstract: The present invention describes a laboratory system for automatically processing at least one sample container containing a biological sample, the laboratory system comprising a housing; laboratory instrument units for executing processing steps on the biological sample; an input station configured to receive the sample container; a transport means for transport of the sample container from the input station to the laboratory instrument units, and further to an output station; a control unit for determining whether the sample and/or the container is in a condition to be processed by the laboratory instrument units; an input-output station providing an interface between the inside and the outside of the housing; and a workbench on the outside of the housing in front of the input-output station for an operator to be in the position to manipulate the sample and/or the container.Type: GrantFiled: October 18, 2018Date of Patent: June 18, 2024Assignee: Roche Molecular Systems, Inc.Inventors: Andreas Gisler, Mike Mohns, Vijay Namasivayam, Maren Christin Wolff, Devorah Klein, Tim Moulton, Sam Palmer, Eric Saperstein
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Patent number: 12011719Abstract: In accordance with embodiments herein a method for capturing cells of interest in a digital microfluidic system is provided, comprising utilizing a droplet actuator to transport a sample droplet to a microwell device. The microwell device includes a substrate having a plurality of microwells that open onto a droplet operations surface of the microwell device. The sample droplet includes cells of interest that enter the microwells. The method introduces capture beads to the microwells, and the capture elements are immobilized on the capture beads. The method utilizes the droplet actuator to transport a cell lysis reagent droplet to the microwell device. Portions of the cell lysis reagent droplet enter the microwells and, during an incubation period, cause the cells of interest to release analyte that is captured by the capture elements on the capture beads.Type: GrantFiled: December 17, 2021Date of Patent: June 18, 2024Assignee: Illumina, Inc.Inventors: Arash Jamshidi, Yan-you Lin, Farnaz Absalan, Sarah Stuart, Gordon Cann, Yir-Shyuan Wu, Tarun Khurana, Jeffrey S Fisher
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Patent number: 11988682Abstract: A transfer system (1) is a transfer system (1) that transfers a sample container (S) containing a sample from a transfer source device (100) to a transfer destination device (200) disposed adjacent to the transfer source device (100), and the transfer system (1) includes an arm (2) having a distal end and a proximal end, the distal end portion facing the transfer destination device (200), and a first catcher (4) for detachably holding the sample container (S) at the distal end, a drive mechanism (14) provided in the transfer source device (100) and configured to drive the arm (2) to move the first catcher (4) between a first position in the transfer source device (100) and a second position in the transfer destination device (200), and a second catcher (16) provided in the transfer destination device (200) and provided so that the sample container (S) is delivered and received between the first catcher (4) and the second catcher (16) when the first catcher (4) reaches the second position.Type: GrantFiled: December 20, 2021Date of Patent: May 21, 2024Assignee: SHIMADZU CORPORATIONInventors: Katsuhiko Seki, Hikaru Shibata, Hiroyuki Matsumoto
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Patent number: 11987842Abstract: A method of preparing reagents includes inserting a cartridge into an instrument. The cartridge includes a plurality of reagent enclosures disposed in a cavity of the cartridge and exposing a port to an exterior of the cartridge. Each reagent enclosure includes a reagent container including a reagent and an internal cavity defining a compressible volume, an opening defined through the reagent container to the internal cavity. The method further includes connecting a plurality of fluid ports to the openings of the plurality of reagent enclosures; applying a solution through the fluid ports to at least partially fill the plurality of reagent enclosures; and cycling a pressure of the cavity, whereby for each of the reagent enclosures, during increasing pressure, the solution enters the internal cavity of the reagent container, combines with the reagent, and compresses the compressible volume, and during decreasing pressure, the compressible volume decreases and the reagent is ejected through the opening.Type: GrantFiled: January 11, 2021Date of Patent: May 21, 2024Assignee: Life Technologi s CorporationInventors: Jonathan Schultz, Todd Roswech, Jon A. Hoshizaki, Albert L. Carrillo, James A Ball
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Patent number: 11988540Abstract: An apparatus includes a probe configured to provide at least a portion of capacitance of an inductance-capacitance (LC) circuit of a detection circuit, the capacitance of the LC circuit being dependent on a distance between the probe and a surface of a liquid in a biochemical analysis system. The apparatus includes a movement mechanism configured to move the probe. The apparatus includes circuitry configured to perform operations that include causing the movement mechanism to move the probe with respect to the liquid; measuring one or more characteristics of an output signal of the detection circuit, the one or more characteristics being dependent on the capacitance of the LC circuit; and detecting, based on the one or more characteristics of the output signal, a contact between the probe and the surface of the liquid.Type: GrantFiled: August 15, 2022Date of Patent: May 21, 2024Assignee: Instrumentation Laboratory Co.Inventors: Reed Hebert, Benjamin Newton, Len Merrill
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Patent number: 11971416Abstract: An analysis apparatus (1) includes a housing unit (10) that houses a biological sample (S), a staining dispenser unit (20) that fluorescently stains the biological sample (S), an image acquisition unit (30) that acquires an image of the biological sample (S), a washer unit (40) that destains the biological sample (S), a drive unit (50), and a control unit (90) that analyzes the image and controls the drive unit (50). The control unit (90) performs adjustments so that the staining dispenser unit (20) and the housing unit (10) satisfy a first position condition, performs adjustments so that the image acquisition unit (30) and the housing unit (10) satisfy a second position condition, and performs adjustments so that the washer unit (40) and the housing unit (10) satisfy a third position condition. The analysis apparatus (1) maximizes the actual photography range of information related to the biological sample.Type: GrantFiled: June 9, 2021Date of Patent: April 30, 2024Assignees: YOKOGAWA ELECTRIC CORPORATION, University of ZurichInventors: Takayuki Kei, Yohei Tsubouchi, Lucas Pelkmans, Gabriele Gut
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Patent number: 11965884Abstract: A method of quantitating free (unbound) human C5 complement protein (C5) from a sample comprising: binding biotinylated anti-C5 capture antibody to strepavidin-coated particles; capturing the free (unbound) C5 in the sample; detecting the captured free C5; and quantitating the captured free C5 using laser-induced fluorescence detection; wherein the method is performed in a Gyros Bioaffy 200 CD in a Gyrolab xPlore or a Gyrolab XP instrument.Type: GrantFiled: October 19, 2017Date of Patent: April 23, 2024Assignee: Alexion Pharmaceuticals, Inc.Inventors: Mark Dysinger, Mark Ma, Bruce A. Andrien
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Patent number: 11958736Abstract: A water purifier or other liquid dispenser may sense a height of the inlet of a container accurately through an infrared transmitter and an infrared receiver that are disposed at different positions of a water discharge module moving vertically. Additionally, in the water purifier, the water discharge module may discharge purified water at a point spaced a certain distance apart from the inlet of the container, based on infrared sensing, thereby preventing the inlet of the container from contacting the lower surface of the water discharge module.Type: GrantFiled: April 24, 2023Date of Patent: April 16, 2024Assignee: LG ELECTRONICS INC.Inventors: Jaehoon Lee, Kyuchun Choi, Dong Seong Kim, Daewoo Kim
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Patent number: 11945239Abstract: A method for controlling a printing process by which a print head prints an image onto predetermined printable area of a label.Type: GrantFiled: August 6, 2021Date of Patent: April 2, 2024Assignee: GEN-PROBE INCORPORATEDInventors: Rolf Silbert, Robert J. Rosati, David Buse, Olev Tammer, Matthias Merten
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Patent number: 11939570Abstract: A microfluidic lab-on-a-chip system for DNA gene assembly that utilizes a DNA symbol library and a DNA linker library. The lab-on-a-chip has a fluidic platform with a plurality of arrays operably connected to a voltage source and a controller for the voltage source, a set of first inlets operably connected to the fluidic platform, each first inlet for one DNA symbol from a DNA symbol library, a set of second inlets operably connected to the fluidic platform, each second inlet for one DNA linker from a DNA linker library, and a mixing area operably connected to the fluidic platform and to the plurality of first inlets and the plurality of second inlets.Type: GrantFiled: April 23, 2020Date of Patent: March 26, 2024Assignee: SEAGATE TECHNOLOGY LLCInventors: Tim Rausch, Walter R Eppler, Gemma Mendonsa
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Patent number: 11933795Abstract: A continuous sample introduction method is provided. The method includes controlling a current sample holder advancing mechanism to perform an advancing operation according to a sample introduction trigger signal, so that the current sample holder advancing mechanism moves in a direction from an initial position to a limiting position, and during the movement, a pushing portion of the current sample holder advancing mechanism is capable of abutting against a side wall of a sample holder in a current sample loading device; controlling the current sample holder advancing mechanism to perform a returning operation when the current sample holder advancing mechanism moves to the limiting position, and during the movement, the pushing portion is capable of avoiding contacting with the sample holder; and the current sample holder advancing mechanism automatically repeats the advancing operation and the returning operation when the current sample holder advancing mechanism moves to the initial position.Type: GrantFiled: December 11, 2020Date of Patent: March 19, 2024Assignees: SHENZHEN MINDRAY BIO-MEDICAL ELECTRONICS CO., LTD., SHENZHEN MINDRAY SCIENTIFIC CO., LTD.Inventors: Yang Zhou, Xianhua Chang, Yang Zhang
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Patent number: 11906406Abstract: Provided is an automatic analysis technique that prevents liquid contained in a reaction container from locally contacting with liquid added afterward and has less occurrence frequency of equipment malfunction and high performance.Type: GrantFiled: April 5, 2018Date of Patent: February 20, 2024Assignees: Hitachi High-Tech Corporation, Roche Diagnostics Operations, Inc.Inventors: Daisuke Ebihara, Shinya Matsuoka, Taku Sakazume, Yuzuru Shimazaki
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Patent number: 11904321Abstract: A container includes a lower portion and a lid to connect with the lower portion. The lid includes a fluidic interface, a swing bar, and a counter structure disposed on an opposite side of the fluidic interface relative to the swing bar. The fluidic interface includes a first liquid port, a second liquid port, a gas port, and a seal ring disposed around the first liquid port, the second liquid port, and the gas port, the first liquid port disposed along a center axis of the container.Type: GrantFiled: May 28, 2020Date of Patent: February 20, 2024Assignee: LIFE TECHNOLOGIES CORPORATIONInventors: Mark Reed, Rui Zheng
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Patent number: 11908673Abstract: An ion molecule reactor for generating analyte ions from analytes comprises: a) a reaction volume in which reagent ions can interact with the analytes in order to form analyte ions; b) at least one analyte inlet for introducing the analytes along an inlet path into the reaction volume whereby, preferably, the inlet path runs essentially along at least a first section of the predefined transit path in the reaction volume; c) at least one reagent ion source and/or at least one reagent ion inlet for providing reagent ions into the reaction volume; d) optionally, at least one ion guide comprising an electrode arrangement which is configured for producing an alternating electrical, magnetic and/or electromagnetic field, that allows for guiding the reagent ions and/or the analyte ions at least along a section of the predefined transit path, preferably along the whole transit path, through the reaction volume.Type: GrantFiled: October 19, 2018Date of Patent: February 20, 2024Assignee: TOFWERK AGInventors: Felipe Lopez-Hilfiker, Manuel Hutterli, Marc Gonin, Carsten Stoermer, Michael Kamrath
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Patent number: 11894110Abstract: To facilitate management of the entirety of one or a plurality of clinical laboratories. This information processing apparatus is used in management of a clinical laboratory in which an analyzer configured to analyze specimens is installed. The information processing apparatus includes: a communication section configured to communicate with a terminal operable by a user; and a controller configured to control display of the terminal via the communication section. On the basis of information collected from a plurality of analyzers installed in one or a plurality of clinical laboratories and from apparatuses relevant to the analyzers, the controller causes the terminal to display a screen including an index that indicates a status of the entirety of the one or the plurality of clinical laboratories. In response to the user selecting the index displayed in the screen, the controller causes the terminal to display the selected index so as to be divided in a plurality of categories.Type: GrantFiled: March 30, 2020Date of Patent: February 6, 2024Assignee: Sysmex CorporationInventors: Akio Miyauchi, Naoki Tsuro, Norio Kowata, Naoki Kai, Shirou Kuwaoka, Yukihisa Minematsu, Mark Dahlberg, Steve Postma, Chris Carrier, Jackie Guenther, Anselm Mueller
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Patent number: 11892205Abstract: A heat pump that includes a thermoelectric device(s) and a heat sink having a raised portion with a top surface for thermally coupling with a planar face of the thermoelectric device(s). The raised portion of the heat sink includes an outer periphery and a raised central region surrounded by a void region to provide more uniform thermal conductivity when clamped within an assembly. The raised central region is shaped in an any shape corresponding to a shape of uneven thermal conductivity due to clamping pressure applied to the heat sink. The void region can be substantially contiguous and entirely circumscribe the central raised region. The device can optionally include discrete supports formed of a less thermally-conductive material within the void region. The supports can be elastomeric, such as O-rings, and disposed within pockets defined within the void region.Type: GrantFiled: November 18, 2022Date of Patent: February 6, 2024Assignee: Bio-Rad Laboratories, Inc.Inventors: Amir Sadri, Nenad Kircanski, Thanh-Vi Tran, Carl Marlowe, Brian David Wilson
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Patent number: 11879901Abstract: This invention relates to an apparatus for conducting immunoassay test. The apparatus includes a groove unit having a groove along a vertical direction configured to hold a rod-shaped portion of a probe along the vertical direction, and a push pin configured to move along a horizontal direction, the push pin being capable of residing at a first position and a second position. A tip of the push pin is capable of pressing the rod-shaped portion of the probe against the groove when the push pin resides at the first position. The distance between the tip of the push pin and the groove is larger than a diameter of the rod-shaped portion of the probe when the push pin resides at the second position.Type: GrantFiled: February 8, 2023Date of Patent: January 23, 2024Assignee: ACCESS MEDICAL SYSTEMS, LTD.Inventors: Hong Tan, Ming Xia, Yushan Tan, Jun Chen, Erhua Cao, Genqian Li, Robert F. Zuk
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Patent number: 11828683Abstract: A method of quantitating free (unbound) human C5a complement protein (C5a) from a sample comprising: binding biotinylated anti-C5a capture antibody to strepavidin-coated particles; capturing the free (unbound) C5 in the sample; detecting the captured free C5a; and quantitating the captured free C5 using laser-induced fluorescence detection; wherein the method is performed in a Gyros Bioaffy 200 CD in a Gyrolab xPlore or a Gyrolab XP instrument; wherein human C5 is first removed from the sample.Type: GrantFiled: October 19, 2017Date of Patent: November 28, 2023Assignee: Alexion Pharmaceuticals, Inc.Inventors: Mark Dysinger, Mark Ma
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Patent number: 11821878Abstract: An autosampler includes an injection port for supplying a sample to an analysis device, a needle that collects the sample stored in a vial and injects the sample into the injection port, a cleaning unit that cleans the needle and a gas exhaust fan. The cleaning unit includes a cleaning container which stores a cleaning liquid and into which the needle is inserted, and a unit main body that has a space for storing the cleaning container and receiving the cleaning liquid overflowing from the cleaning container, and a unit gas exhaust passage for exhausting gas in the space outwardly of the cleaning unit. The unit main body has a unit opening through which the needle passes when accessing the cleaning container.Type: GrantFiled: October 23, 2018Date of Patent: November 21, 2023Assignee: SHIMADZU CORPORATIONInventors: Shotaro Ando, Takashi Inoue
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Patent number: 11815438Abstract: A fluid sampler system includes a fluidic head including a gas aperture capable of communication with a pressurized gas source, a liquid conduit capable of communication with a sample reservoir, and a seal capable of forming a compression seal to the sample reservoir when gas pressure is applied to the sample reservoir through the gas aperture and capable of displacing a portion of the sample through the liquid conduit; and a positioning apparatus capable of positioning the fluidic head and the sample reservoir in communication with one another. A method for providing an aliquot of sample, includes forming a releasable compression seal to a reservoir including a liquid sample; pressurizing the reservoir with compressed gas; displacing an aliquot of the sample from the reservoir; and transferring the displaced aliquot of the sample to a location.Type: GrantFiled: November 5, 2021Date of Patent: November 14, 2023Assignee: CorSolutions LLCInventors: Thomas N. Corso, Colleen K. Van Pelt