Sample Mechanical Transport Means In Or For Automated Analytical System Patents (Class 422/63)
  • Patent number: 10381463
    Abstract: Embodiments are directed to a method and resulting structures for smoothing the sidewall roughness of a post-etched film. A sacrificial layer is formed on a substrate. A patterned mask is formed by removing portions of the sacrificial layer to expose a surface of the substrate. The sidewalls of the patterned mask are smoothed and a target layer is formed over the patterned mask and the substrate. Portions of the target layer are removed to expose a surface of the patterned mask and the patterned mask is removed.
    Type: Grant
    Filed: January 19, 2018
    Date of Patent: August 13, 2019
    Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Kafai Lai, Hari V. Mallela, Hiroyuki Miyazoe, Reinaldo A. Vega, Rajasekhar Venigalla
  • Patent number: 10359443
    Abstract: An automatic fecal occult blood detecting analyzer used to detect a sample box is provided. The analyzer has a feeding chain and a main conveying chain. A plurality of clamping devices for clamping the sample box are provided on the feeding chain and the main conveying chain, respectively. A transferring device of the analyzer transfers the sample box from the feeding chain to the main conveying chain. The analyzer also has a pressing device and an image acquisition device for acquiring tape information presented on test strips of the sample box on the main conveying chain. Continuous detection and accurate location of a plurality of the sample boxes can be implemented without turning over and tilting the sample boxes.
    Type: Grant
    Filed: December 24, 2015
    Date of Patent: July 23, 2019
    Assignee: W.H.P.M. BIORESEARCH AND TECHNOLOGY CO., LTD.
    Inventors: John Wan, Chunhai Zou, Qinghai Xia, Jie Liu
  • Patent number: 10351843
    Abstract: The present invention relates to an automated analytical system and an automated method for separating and detecting an analyte, as well as an automated analytical instrument.
    Type: Grant
    Filed: December 22, 2015
    Date of Patent: July 16, 2019
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Renato Belz, Andreas Gisler, Robert Huesler, Rolf Knobel, Christian Thalmann
  • Patent number: 10330691
    Abstract: A diagnostic analyzer includes a track, a light-blocking member, a motor, and an optical testing device. The track moves a reaction vessel held by the track. The light-blocking member is disposed adjacent to the track. The light-blocking member moves from a first position apart from the track to a second position closer to the track. When the light-blocking member is disposed in the first position a sample contained within the reaction vessel held by the track is exposed to light. When the light-blocking member is disposed in the second position the sample contained within the reaction vessel held by the track is blocked from exposure to the light. The motor moves the light-blocking member between the first and the second positions. The optical testing device is disposed adjacent to the track for optically testing the sample contained within the reaction vessel held by the track when the at least one light-blocking member is disposed in the second position.
    Type: Grant
    Filed: October 31, 2016
    Date of Patent: June 25, 2019
    Assignee: ABBOTT LABORATORIES
    Inventors: Joseph P. Donohue, Ryan Patrick Johnson
  • Patent number: 10330692
    Abstract: The purpose of the present invention is to provide an automatic analysis device that combines a biochemical analysis unit and a blood coagulation analysis unit and has a high processing capacity while reducing device cost and life-cycle cost. An automatic analysis device is characterized in that when a synthetic-substrate item or latex-agglutination item from among synthetic-substrate, latex-agglutination, and clotting-time blood-coagulation-test items is made to be a first test item and the clotting-time item is made to be a second test item, if there is a measurement request for the first test item and second test item in the same specimen rack, a control unit determines the conveyance path of the specimen rack such that the first test item is measured using a biochemical analysis unit and the second test item is measured using a coagulation time analysis unit and controls a conveyance line.
    Type: Grant
    Filed: November 5, 2014
    Date of Patent: June 25, 2019
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Akihisa Makino, Chie Yabutani, Masato Ishizawa
  • Patent number: 10286394
    Abstract: Provided are an analysis chip and a sample analysis device by which it is possible to perform analysis rapidly and accurately on a plurality of items simultaneously using a small amount of liquid for measurement. An analysis chip (10) is provided with: a substrate (20) formed in a substantially disc shape; an insertion hole (22) formed in the center of the substrate (20), a liquid to be measured being inserted into the insertion hole (22); and micro-flow paths (23) into which the liquid to be measured can be guided from the insertion hole (22) by capillary action, each of the micro-flow paths (23) having therein a plurality of types of antigens (30) that are fixed in place with gaps therebetween, the antigens (30) selectively reacting to components in the liquid to be measured.
    Type: Grant
    Filed: May 12, 2015
    Date of Patent: May 14, 2019
    Assignee: Takano Co., Ltd.
    Inventors: Kazutaka Hori, Tamotsu Minegishi, Shinya Yamamoto, Takamitsu Godo
  • Patent number: 10267815
    Abstract: A device for positioning vessels, with a holder for vessels, comprising a series of receptacles arranged on a circular line, for a circular ring-shaped vessel chain, a central area, arranged within the series of receptacles, and having further receptacles for single vessels containing reagents, and means for aligning, and with a carrier for single vessels, which comprises a holding plate in the form of a circular disc or of a part of a circular disc, which has holes for single vessels at certain positions, and which has at least one further means for aligning the carrier to the means for aligning the holder in a certain position, wherein in this position, the holes are aligned to certain further receptacles, the remaining further receptacles are covered up by the holding plate, and single vessels filled with reaction liquid can be inserted into the holes and into the further receptacles aligned thereto.
    Type: Grant
    Filed: May 30, 2012
    Date of Patent: April 23, 2019
    Assignee: Eppendorf AG
    Inventors: Helmut Knofe, Jens-Peter Kroog, Judith Lucke
  • Patent number: 10261016
    Abstract: A specimen analyzing method and a specimen analyzing apparatus capable of measuring interference substances before analyzing a specimen. The method comprises a step for sucking the specimen stored in a specimen container (150) and sampling it in a first container (153), a step for optically measuring the specimen in the first container, a step for sampling the specimen in a second container (154) and preparing a specimen for measurement by mixing the specimen with a reagent in the second container, and a step for analyzing the specimen for measurement according to the results of the optical measurement of the specimen.
    Type: Grant
    Filed: March 15, 2016
    Date of Patent: April 16, 2019
    Assignee: SYSMEX CORPORATION
    Inventors: Norimasa Yamamoto, Takashi Yamato, Naohiko Matsuo, Satoshi Iguchi
  • Patent number: 10241123
    Abstract: Disclosed is a method of operating a laboratory instrument (100, 1000), wherein the laboratory instrument is configured for receiving a sample rack (112) with one or more sample tubes (126), wherein the laboratory instrument comprises a robotic head (106) for bringing a pipettor (108) into fluidic contact with the one or more sample tubes when the sample rack is in an operating position (122), wherein the robotic head is configured for loading the sample rack into the operating position, and wherein the method comprises the steps of: receiving (200) the sample rack by the laboratory instrument; and loading (202) the rack into the operating position using the robotic head.
    Type: Grant
    Filed: November 29, 2016
    Date of Patent: March 26, 2019
    Assignee: ROCHE MOLECULAR SYSTEMS, INC.
    Inventors: Kurt Barmettler, Andre Peter
  • Patent number: 10234364
    Abstract: First and second racks each has fixed positions to hold sample tubes. First and second drawers slide into and out of the case, and that support the first and second racks, respectively. A tube set unit is provided in an area close to the first rack in the case. A tube transfer unit removes sample tubes from the first and second racks in the case and a controller that controls a transfer operation of the tube transfer unit. The first rack is supported by the first drawer such that the first rack leaves a transit location in the case behind the first drawer in the direction of the first drawer movement into the case. The controller controls the tube transfer unit to remove at least one sample tube from the second rack and transfers the tube to the tube set unit via a path traversing the transit location.
    Type: Grant
    Filed: June 29, 2017
    Date of Patent: March 19, 2019
    Assignee: SYSMEX CORPORATION
    Inventors: Takaaki Nagai, Daigo Fukuma, Mitsuo Yamasaki, Noriyuki Nakanishi, Syunsuke Yao, Tomonori Okazaki, Takahiro Saino
  • Patent number: 10234472
    Abstract: Disclosed is an automatic analysis device in which a check item at a time of an analysis start can be set in accordance with a skill level of an operator, an analysis can be performed after the check item being displayed and confirmed, and erroneous measurement caused due to a missed check can be prevented. The check item such as checking the remaining quantity of a reagent or the like displayed in a check screen before the analysis start can be set for each type of operator, each day, each time. The set check item is configured to be displayed in a screen before the analysis start, and unless the operator confirms the check item, the analysis start is not allowed in principle. An automatic analysis device which can prevent erroneous measurement caused due to a missed check of the operator before the analysis start is realized.
    Type: Grant
    Filed: April 7, 2015
    Date of Patent: March 19, 2019
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Hirofumi Sasaki, Toshihide Hanawa, Tsuguhiko Satou, Yoshihiro Naitou
  • Patent number: 10234473
    Abstract: An analytical device for automated determining of a measured variable of a liquid sample comprises: a liquid storage, which includes one or more liquid containers for one or more liquids; a measuring cell for accommodating the liquid sample, especially a liquid sample, to which has been added one or more liquids from the liquid storage, and a measuring arrangement for providing one or more measurement signals correlated with the measured variable; an electronics unit, which includes a control unit for control of the analytical device and for determining the measured variable based on the measurement signals provided by the measuring arrangement; and a handling unit including a supply- and dosing, or metering, system for supplying and metering the liquid sample and liquids from the liquid storage into the measuring cell, wherein the analytical device includes at least one exchangeable cassette, into which are integrated at least parts of the liquid storage and/or at least parts of the handling unit.
    Type: Grant
    Filed: August 17, 2010
    Date of Patent: March 19, 2019
    Assignee: Endress+Hauser Conducta GmbH+Co. KG
    Inventors: Ralf Steuerwald, Ulrich Kathe
  • Patent number: 10227287
    Abstract: Described is a method of detecting and/or determining levels of incorporation of monolignol ferulate conjugate esters into lignin by derivatizing the lignin, reductively cleaving the lignin, labeling the cleavage products, and then detecting cleavage products derived from monolignol ester conjugates via differential attachment of the label.
    Type: Grant
    Filed: December 31, 2015
    Date of Patent: March 12, 2019
    Assignee: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: John Ralph, Steven D Karlen, Fachuang Lu, Dharshana Padmakshan
  • Patent number: 10220360
    Abstract: During the use of a liquid mixing apparatus, a liquid container can be installed onto an adapter. The liquid container drives a lifting assembly to allow a piercing assembly to pierce through the adapter. Once a fluid flows into a flowing passage portion via a fluid inlet, a portion of the fluid is pressurized via a branch passage portion with easy control and further flows into the liquid container to mix with a fragrance material inside the liquid container. The mixed fragrant liquid then flows out of a fluid outlet from the piercing assembly via the return passage portion and the flowing passage portion. With the pressurization design of the branch passage portion, the apparatus allows the increase of dimension to increase the flow rate while maintaining the pressurized liquid, which is convenient to use and facilitated for the control of the mixture amount with greater variation range.
    Type: Grant
    Filed: August 9, 2017
    Date of Patent: March 5, 2019
    Assignee: AROTEC CORPORATION
    Inventors: Ching-Hua Wang, Yu-Wen Yen
  • Patent number: 10215647
    Abstract: Methods and systems accurately determine an analyte concentration in a fluid sample. In an example embodiment, a receiving port receives a test sensor. The test sensor includes a fluid-receiving area for receiving a fluid sample. The fluid-receiving area contains a reagent that produces a measurable reaction with an analyte in the fluid sample. The test sensor has a test-sensor temperature and the reagent has a reagent temperature. A measurement system measures the reaction between the reagent and the analyte. A temperature-measuring system measures the test sensor temperature when the test sensor is received into the receiving port. A concentration of the analyte in the fluid sample is determined according to the measurement of the reaction and the measurement of the test sensor temperature. A diagnostic system determines an accuracy of the temperature-measuring system. The calculation of the analyte concentration may be adjusted according to the accuracy of temperature-measuring system.
    Type: Grant
    Filed: December 14, 2017
    Date of Patent: February 26, 2019
    Assignee: ASCENSIA DIABETES CARE HOLDINGS AG
    Inventors: Narasinha Parasnis, Hoi-Cheong Steve Sun, Mu Wu
  • Patent number: 10196955
    Abstract: A method includes determining whether a urea refill event is detected, and clearing a quality accumulator value and clearing a latching abort command. The method includes determining whether urea fluid quality check abort conditions are met, and clearing the urea quality accumulator, latching the abort command, and exiting the reductant fluid quality check. In response to the abort conditions not being met, incrementing the urea quality accumulator according to an amount of urea being injected, and comparing the accumulated urea quantity to a low test threshold. The method includes, in response to the accumulated urea quantity being greater than the low test threshold, comparing the accumulated urea quantity to a high test threshold, and in response to the urea quantity being greater than the high test threshold, determining whether the a NOx exceedance is observed and clearing a urea quality error in response to the NOx exceedance not being observed.
    Type: Grant
    Filed: June 8, 2016
    Date of Patent: February 5, 2019
    Assignee: Cummins Emission Solutions Inc.
    Inventors: Xi Wei, David Samuel Everard, Baohua Qi, Mickey R. McDaniel, Edmund P. Hodzen, Guoquian Li
  • Patent number: 10192637
    Abstract: This specimen analyzer includes: an analysis unit which analyzes a specimen collected from a subject; a print unit which prints on a print sheet; a display unit which displays an operation screen; and a controller which performs control of causing the print unit to print an analysis result of the analysis unit, and prohibiting the display unit from displaying the analysis result.
    Type: Grant
    Filed: May 31, 2017
    Date of Patent: January 29, 2019
    Assignee: SYSMEX CORPORATION
    Inventors: Seiji Takemoto, Takeshi Komoto, Hideki Hirayama, Takashi Yoshida, James Ausdenmoore
  • Patent number: 10184948
    Abstract: An automated analyzer maintains high processing capacity and dispensation accuracy even when items requiring dilution/pretreatment and general reaction measurement are mixed. A plurality of sample dispensing mechanisms are independently driven and each include a sample collection position, a sample nozzle for collecting the sample, and a washing tank for washing the sample nozzle. The sample dispensing mechanisms are configured to collect the sample from a plurality of sample collection positions and are operated independently to perform sample dispensation into reaction containers on a reaction disc. At least one of the sample dispensing mechanisms is provided for each of a sample requiring dilution/pretreatment and a sample that does not require dilution/pretreatment. The automated analyzer is provided with a control means for causing the respective mechanisms to be operated in a dedicated manner. The sample is dispensed such that no vacancy is created in the reaction containers.
    Type: Grant
    Filed: August 24, 2016
    Date of Patent: January 22, 2019
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Akihiro Yasui, Yoshihiro Suzuki, Hitoshi Tokieda
  • Patent number: 10184104
    Abstract: The present invention provides a self-draining well plate cassette and an automated system for cultivating C. elegans comprising a housing, a well plate assembly having at least two of the self-draining well plate cassettes, a liquid dispensing assembly operated by a first three axes positioner, a wash and imaging assembly operated by a second three axis positioner, a reagent assembly, a pipette tip holder, and a controller. The present invention further provides a method of using the above-described system to cultivate C. elegans.
    Type: Grant
    Filed: October 12, 2016
    Date of Patent: January 22, 2019
    Inventors: Alexander Lee Lianides, Christopher Lee Lianides
  • Patent number: 10168345
    Abstract: An automatic analysis apparatus capable of improving detection sensitivity is provided. An optimum photometer between a light-scattering photometer and an absorptiometer based on a concentration range may be decided. A standard solution is measured multiple times at a normal calibration and a calibration curve is created. Calibration curves are individually created for an absorptiometer and a light-scattering photometer from the minimum and maximum measured values of the concentrations of each standard solution. The upper and lower limits of a standard solution concentration are computed from the minimum/maximum calibration curves. Sensitivity may be computed by using calibration parameters. Whether to use a concentration by absorption or a concentration by scattered light is decided based on the computed sensitivity. The computed sensitivities are compared between the concentration by absorption and the concentration by scattered light, and the use of the concentration of a higher sensitivity is decided.
    Type: Grant
    Filed: May 30, 2013
    Date of Patent: January 1, 2019
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Akiko Yokokawa, Tomonori Mimura, Sakuichiro Adachi
  • Patent number: 10151673
    Abstract: A treatment device (1) for treating histological or cytological samples has a plurality of containers (6) for different treatment agents and a detection apparatus (2) for detecting a code which unequivocally identifies a type of a treatment agent or a type of a group of treatment agents from a package or replacement container of a treatment agent or group of treatment agents. The device furthermore has an evaluation apparatus (18) that, based on a detected code, ascertains which of the containers is or are to be replenished or replaced, and an indicating apparatus (4) which communicates to a user the ascertained container (6) or containers (6) that is or are to be replenished or replaced. The indicating apparatus may include a display (5) presenting a schematic image of the plurality of containers (6) with image(s) of each ascertained container being marked, and/or a light source (15) that illuminates each ascertained container.
    Type: Grant
    Filed: June 22, 2017
    Date of Patent: December 11, 2018
    Assignee: Leica Biosystems Nussloch GmbH
    Inventors: Bernhard Neef, Markus Wittmann
  • Patent number: 10151765
    Abstract: A method for processing sample tubes comprising biological samples is presented. The method comprises transporting a sample tube closed by a closure to a first work cell, removing the closure with a first decapping/recapping device; withdrawing from the sample tube a sample aliquot with a pipetting unit for processing by the first work cell and/or dispensing liquid into the sample tube and/or determining a sample parameter with an analytical unit, reclosing the sample tube with a closure with the first decapping/recapping device, transporting the sample tube to a second work cell, removing the closure with a second decapping/recapping device, and withdrawing from the sample tube a sample aliquot with a pipetting unit for processing by the second work cell and/or dispensing a volume of liquid into the sample tube and/or determining a sample parameter of the sample with of an analytical unit.
    Type: Grant
    Filed: June 16, 2016
    Date of Patent: December 11, 2018
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Dietmar Kappelhoff, Gottlieb Schacher
  • Patent number: 10139422
    Abstract: Methods and systems for performing tests in an in vitro diagnostic environment provide for a substantially optimized distribution of testing reagents amongst a plurality of analyzers. The system and method can include steps of identifying a plurality of expected tests to be performed by a plurality of analyzer modules, determining information about the capabilities of the plurality of analyzer modules, and receiving, at the processor, data reflecting which of the plurality of tests are incompatible. Further steps can include calculating a substantially optimal distribution of the plurality of expected tests amongst the plurality of analyzer modules, allocating reagents to each of the plurality of analyzer modules by facilitating distribution of a plurality of reagents to selected analyzer modules in response to the step of calculating, and automatically scheduling a plurality of samples to undergo tests at the plurality of analyzer modules.
    Type: Grant
    Filed: January 9, 2014
    Date of Patent: November 27, 2018
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Benjamin S. Pollack, Colin Mellars, Baris Yagci
  • Patent number: 10106769
    Abstract: An automatic culturing device configured such that, in a work chamber 2a maintained in a sterile state, first and second robots 6 and 7 are arranged so that the movable ranges thereof partially overlap each other, and such that liquid supply means 10 which supplies liquids, containing a culture medium and liquid medicine, to containers held by the robots, and temporary placement sections (handing-over table 42, centrifuge tube holder 43, and heated room 44), each of which hands over the containers between the first and second robots, are provided in the movable ranges of the first and second robots, which ranges overlap each other. The first robot takes out the containers housed in housing means (rotary stocker 8), and the second robot holds and transports the containers handed over from the first robot via the temporary placement section. The cultivating operation can be efficiently performed.
    Type: Grant
    Filed: June 12, 2015
    Date of Patent: October 23, 2018
    Assignee: SHIBUYA CORPORATION
    Inventors: Masahiro Sakamoto, Noriaki Nishimura
  • Patent number: 10107806
    Abstract: The apparatus has a containing body with a flat upper functional floor for containing receptacles of reagents, diluents and samples, as well as housings for gel cards and incubators for the same; a lower floor containing receptacles for washing liquids and the collection of waste and cards and for housing the fluid control and electronic control system; a series of longitudinal and transverse guides associated with the upper part of the apparatus, suitable for carrying in suspension the moving heads of the apparatus, the heads being movable on the transverse guides; two heads, respectively for perforation and pipetting and for the transport of gel cards; two centrifuges and a gel card reader; and a folding touch screen providing information and control.
    Type: Grant
    Filed: May 6, 2016
    Date of Patent: October 23, 2018
    Assignee: GRIFOLS, S.A.
    Inventors: Enrique Martinell Gispert-Sauch, Jordi Puig Cebria
  • Patent number: 10101348
    Abstract: The sample analyzer includes: a reagent arranging section for arranging a plurality of reagents; an analyzing section for analyzing a measurement sample prepared by mixing a sample and the reagent arranged on the reagent arranging section; a display device; an input device; and a display control section for displaying a reagent arrangement displaying region for displaying a plurality of reagent marks inscribed with a reagent name respectively on the display device, wherein the each reagent mark is displayed in a manner selectable by the input device, wherein arrangement of the each reagent mark on the reagent arrangement displaying region corresponds to arrangement of the each reagent on the reagent arranging section, wherein the display control section displays detailed information related to the reagent corresponding to the reagent mark selected by the input device on the display device.
    Type: Grant
    Filed: June 2, 2016
    Date of Patent: October 16, 2018
    Assignee: Sysmex Corporation
    Inventors: Hiroyuki Fujino, Kyozo Fujita, Mitsuyo Ito
  • Patent number: 10101345
    Abstract: Disclosed is a test strip pickup mechanism configured to pick up test strips for liquid sample analysis one by one from a test strip bottle, the test strip pickup mechanism including: a pickup head configured to suck and hold a test strip; and a motor for rotating the pickup head, wherein the pickup head is provided with a suction hole for sucking and holding the test strip, and the motor is a hollow motor, a hollow portion thereof being connected to the suction hole.
    Type: Grant
    Filed: March 23, 2016
    Date of Patent: October 16, 2018
    Assignee: SYSMEX CORPORATION
    Inventors: Satoshi Takai, Hanako Yura, Shingo Hatada, Yasuhiro Miyake
  • Patent number: 10094844
    Abstract: In determining whether a rack inputted to the automatic analyzer by the user is to be transferred to an analysis section or not, samples existing in a route from a buffer to a sample dispensing position in the analysis section are identified, and the number of items in which suction by a nozzle has not been completed in analysis items requested for the samples is managed. When the number of items is reduced to be smaller than a given number, the conveyance of a next rack from the buffer to the analysis section is controlled, thereby limiting the number of analysis items requested for samples in a waiting state for analysis in the analysis section constantly to be smaller than a fixed number. As a result, a period of time until a measurement result of emergency samples is outputted can be reduced even when emergency samples are newly inputted.
    Type: Grant
    Filed: June 29, 2012
    Date of Patent: October 9, 2018
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Yoshiaki Saito, Kazuhiro Nakamura, Naoto Suzuki, Toshihide Orihashi
  • Patent number: 10094846
    Abstract: A sample-processing system that improves total system processing efficiency, and reduces a sample-processing time, by establishing a functionally independent relationship between a rack conveyance block with rack supply, conveyance, and recovery functions, and a processing block with sample preprocessing, analysis, and other functions. A buffer unit with random accessibility to multiple racks standing by for processing is combined with each of multiple processing units to form a pair, and the system is constructed to load and unload racks into and from the buffer unit through the rack conveyance block so that one unprocessed rack is loaded into the buffer unit and then upon completion of process steps up to automatic retesting, unloaded from the buffer unit. Functional dependence between any processing unit and a conveyance unit is thus eliminated.
    Type: Grant
    Filed: December 2, 2015
    Date of Patent: October 9, 2018
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Hitoshi Tokieda, Yoshimitsu Takagi, Takeshi Shibuya, Masashi Akutsu
  • Patent number: 10068991
    Abstract: Embodiments are directed to a method and resulting structures for smoothing the sidewall roughness of a post-etched film. A sacrificial layer is formed on a substrate. A patterned mask is formed by removing portions of the sacrificial layer to expose a surface of the substrate. The sidewalls of the patterned mask are smoothed and a target layer is formed over the patterned mask and the substrate. Portions of the target layer are removed to expose a surface of the patterned mask and the patterned mask is removed.
    Type: Grant
    Filed: February 21, 2017
    Date of Patent: September 4, 2018
    Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Kafai Lai, Hari V. Mallela, Hiroyuki Miyazoe, Reinaldo A. Vega, Rajasekhar Venigalla
  • Patent number: 10036760
    Abstract: A sample analyzer comprises an input to select a sample type to be measured from a plurality of platelet sample types of differing concentrations, a measurement part to obtain optical information of a sample, a processing part that calculates platelet aggregation information from the optical information, and an alarm part. The processing part determines whether the actual measured sample type differs from the inputted sample type based on the optical information from the measurement part, and actuates the alarm part accordingly.
    Type: Grant
    Filed: March 27, 2015
    Date of Patent: July 31, 2018
    Assignee: SYSMEX CORPORATION
    Inventors: Keiichi Yamaguchi, Hiroshi Kurono, Katsushi Kobayashi
  • Patent number: 10031150
    Abstract: A laboratory sample distribution system is presented. The laboratory sample distribution system comprises a plurality of container carriers. The container carriers each comprise at least one magnetically active device such as, for example, at least one permanent magnet, and carry a sample container containing a sample. The system further comprises a transport plane to carry the multiple container carriers and a plurality of electro-magnetic actuators stationary arranged below the transport plane. The electro-magnetic actuators move a container carrier on top of the transport plane by applying a magnetic force to the container carrier. The system also comprises at least one transfer device to transfer a sample item, wherein the sample item is a container carrier, a sample container, part of the sample and/or the complete sample, between the transport plane and a laboratory station such as, for example, a pre-analytical, an analytical and/or a post-analytical station.
    Type: Grant
    Filed: December 15, 2016
    Date of Patent: July 24, 2018
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Michael Heise, Hans Schneider
  • Patent number: 10024875
    Abstract: An apparatus for moving and testing biological samples is described, comprising a laboratory automation system for moving transporting devices of single test tubes containing biological material samples, a testing module of said biological material samples contained in said test tubes adapted to receive linear containers of a plurality of test tubes arranged in a series of consecutive housings along a line, and an interconnection module between said laboratory automation system and said testing module.
    Type: Grant
    Filed: March 13, 2015
    Date of Patent: July 17, 2018
    Assignee: INPECO HOLDING LTD.
    Inventor: Gianandrea Pedrazzini
  • Patent number: 10024849
    Abstract: Embodiments of the present invention include methods for conducting agglutination assays using sedimentation. Aggregates may be exposed to sedimentation forces and travel through a density medium to a detection area. Microfluidic devices, such as microfluidic disks, are described for conducting the agglutination assays, as are systems for conducting the assays.
    Type: Grant
    Filed: September 14, 2015
    Date of Patent: July 17, 2018
    Assignee: National Technology & Engineering Solutions of Sandia, LLC
    Inventors: Ulrich Y. Schaff, Gregory Jon Sommer, Anup K. Singh
  • Patent number: 10018542
    Abstract: A method and an automated apparatus for processing at least one biological sample arranged on a slide. At least one capillary staining module has a slide rack holder configured to detachably hold a slide rack configured to hold slides, and a capillary lid rack holder configured to detachably hold a capillary lid rack configured to hold capillary lids, wherein the slide rack can be removed independently of removing the capillary lid rack. A first fluid container has a first fluid. The apparatus being configured to automatically rotate the one or more slides, and to move the lids towards the slides to automatically form a capillary gap between each slide and each capillary lid, said capillary gap functioning as a capillary chamber; and to supply an amount of the first fluid to the slide.
    Type: Grant
    Filed: October 2, 2014
    Date of Patent: July 10, 2018
    Assignee: DAKO DENMARK A/S
    Inventors: Søren Damgaard Larsen, Peter Axel Valbjørn
  • Patent number: 10011015
    Abstract: A biological reaction apparatus for receiving at least one substrate having a sample located in a sample region, and a separate cover, such that a reaction chamber is formed between the cover and substrate over the sample region, wherein the apparatus includes a locating means to locate the substrate; a cover locating means for locating and moving the cover with respect to the substrate; a fluid dispensing means for dispensing fluid into the reaction chamber; and a draining mechanism; wherein the draining mechanism includes wicking means.
    Type: Grant
    Filed: December 14, 2012
    Date of Patent: July 3, 2018
    Assignee: LEICA BIOSYSTEMS MELBOURNE PTY LTD
    Inventors: Stuart Elliot, Andrew McLellan, Chester Henderson, Mark Dockrill, Simon Harris, Peter Riddell
  • Patent number: 10001499
    Abstract: Systems and methods are provided for performing a work-flow, which may be in an IVD environment. A plurality of workcells can be used to perform tasks, while vessels can be automatically transported between the workcells using bulk transport trays along an inter-cell track, allowing each workcell to be independently adapted to one or more tasks in the work-flow.
    Type: Grant
    Filed: October 11, 2013
    Date of Patent: June 19, 2018
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Colin Mellars, Baris Yagci, Benjamin S. Pollack
  • Patent number: 9996543
    Abstract: A system optimizes performance of analytics and includes at least one processor. The system analyzes a specification of an analytic produced in accordance with a schema, where the specification indicates a set of conditions for members of a population to determine the analytic. The system compresses the specification by modifying constructs within the specification to produce a compressed specification of a reduced size and complying with the schema, where modifying the constructs within the specification includes removing duplicate portions, combining logical conditions, and removing portions with unused data. The system further performs the analytic based on the compressed specification. Embodiments further include a method and computer program product for optimizing performance of analytics in substantially the same manner as the system.
    Type: Grant
    Filed: January 6, 2016
    Date of Patent: June 12, 2018
    Assignee: International Business Machines Corporation
    Inventors: James C. Baiera, Jill R. Doty
  • Patent number: 9952234
    Abstract: A method for determining a physical property of a biological sample. The method comprises the steps of: acquiring a set of preliminary calibration signals of a first lot of a reagent using an automatic analyzer with a first photometry module; acquiring a reference set of signals of the first lot of the reagent using a calibration analyzer with a second photometry module; determining a set of module specific components by subtracting the reference set of signals from the preliminary calibration signals; acquiring a lot specific set of signals of a second lot of the reagent using the second photometry module; determining a lot calibration for the first photometry module using the set of module specific components and the lot specific set of signals; acquiring a measurement signal of the biological sample using the first photometry module and the second lot of the reagent; and determining a physical property of the biological sample using the measurement signal and the lot calibration.
    Type: Grant
    Filed: December 11, 2015
    Date of Patent: April 24, 2018
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Martin Horstmann, Fridl Lang
  • Patent number: 9927451
    Abstract: An integrated automation system for use in transporting samples between modules, the system can include a plurality of modules configured to be connected to one another for processing samples, each of the plurality of modules having an internal transport system. Each internal transport system includes one or more periphery track portions integrated within a respective module, each of the periphery track portions having two ends and one or more transverse track portions integrated within the respective module, the one or more transverse track portions intersecting at least one of the one or more periphery track portions. The internal transport systems can be configured to connect to one another via one end of the two ends connecting to one end of the two ends of adjacent periphery track portions, thereby forming a continuous periphery track running through and connecting the plurality of modules. Samples are transported along the continuous periphery track and the one or more transverse track portions.
    Type: Grant
    Filed: March 29, 2013
    Date of Patent: March 27, 2018
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Benjamin Samuel Pollack, Colin Mellars, Baris Yagci
  • Patent number: 9927332
    Abstract: A slide transport system for an automated slide treatment apparatus having slide treatment modules for receiving slides and a fluid dispensing robot configured by a controller to dispense reagents to the slides is disclosed. The slide transport system includes a slide transport robot configured by the controller to move the slides to and from the slide treatment modules and a slide transport device disposed on the slide transport robot and configured by the controller to releasably hold the slides. A slide handling head on the slide transport robot moves a closure body of a slide treatment module from a normally closed to an open position to move slides in the slide treatment module. The slide transport device is configured by the controller to release a slide when located in the slide treatment module, when the closure body is in the open position.
    Type: Grant
    Filed: November 1, 2013
    Date of Patent: March 27, 2018
    Assignee: LEICA BIOSYSTEMS MELBOURNE PTY LTD
    Inventors: Mark Brian Dockrill, Martin Limon, Mark Wilcock, Steve Collins, Brendyn Rodgers
  • Patent number: 9891174
    Abstract: Disclosed herein are a reactor, a test apparatus, and a test method, which measure, when a material included in a sample acts as an interfering material with respect to estimating a concentration of a target material, a concentration of the interfering material, and correct an estimated concentration of the target material based on the concentration of the interfering material, thereby improving the reliability and accuracy of the concentration of the target material. The reactor includes: a target material detecting chamber in which a first reagent that includes a first material that is activated by a target material is contained; a first material detecting chamber in which a second reagent that includes the target material is contained; an inlet hole into which a sample is injected; and a channel configured to connect the inlet hole, the target material detecting chamber, and the first material detecting chamber to each other.
    Type: Grant
    Filed: December 31, 2015
    Date of Patent: February 13, 2018
    Assignee: SAMSUNG ELECTRONICS CO., LTD.
    Inventors: Kui Hyun Kim, Sang Bum Park, Joo Hee Park
  • Patent number: 9873200
    Abstract: A personal robot including a first smart device, a robot main body, and a second smart device is implemented as a first type where the first smart device is wirelessly connected to the robot main body, as a second type where the first smart device is mounted on and connected to the robot main body in a wired manner, or as a third type where the second smart device is wirelessly connected to the robot main body where the first smart device is mounted on and connected to the robot main body in a wired manner. In the third type, the robot main body is connected to the first smart device in a wired manner and wirelessly connected to the second smart device, and a robot main body control unit controls the robot main body according to simultaneously processed data from the first and second smart devices.
    Type: Grant
    Filed: August 28, 2013
    Date of Patent: January 23, 2018
    Assignee: FUTURE ROBOT CO., LTD.
    Inventors: Se Kyong Song, Sang Ki Lee
  • Patent number: 9874481
    Abstract: Methods and systems accurately determine an analyte concentration in a fluid sample. In an example embodiment, a receiving port receives a test sensor. The test sensor includes a fluid-receiving area for receiving a fluid sample. The fluid-receiving area contains a reagent that produces a measurable reaction with an analyte in the fluid sample. The test sensor has a test-sensor temperature and the reagent has a reagent temperature. A measurement system measures the reaction between the reagent and the analyte. A temperature-measuring system measures the test sensor temperature when the test sensor is received into the receiving port. A concentration of the analyte in the fluid sample is determined according to the measurement of the reaction and the measurement of the test sensor temperature. A diagnostic system determines an accuracy of the temperature-measuring system. The calculation of the analyte concentration may be adjusted according to the accuracy of temperature-measuring system.
    Type: Grant
    Filed: June 30, 2014
    Date of Patent: January 23, 2018
    Assignee: Ascensia Diabetes Care Holdings AG
    Inventors: Narasinha Parasnis, Hoi-Cheong Steve Sun, Mu Wu
  • Patent number: 9864349
    Abstract: In accordance with embodiments, there are provided mechanisms and methods for facilitating hybrid solutions for staining of specimens according to one embodiment. In one embodiment and by way of example, a method includes receiving a request for a staining process for a specimen placed on a specimen container that is further placed within a process chamber, where the specimen includes a specimen needing a diagnosis. The method may further include reading or capturing process data relating to the specimen, where the process data includes at least one of basic information and customization instructions. The method may further include facilitating the staining process of the specimen based on the process data.
    Type: Grant
    Filed: December 23, 2013
    Date of Patent: January 9, 2018
    Assignee: Piesi, Inc.
    Inventors: Mark Andrew Collins, Mary Virginia Riley
  • Patent number: 9835559
    Abstract: A urine specimen analysis device includes a specimen drawing portion, a sample preparing portion, a measurement portion, and an information processing portion. The specimen drawing portion draws a first aliquot and a second aliquot from a urine specimen. The sample preparing portion prepares a first measurement sample by mixing the first aliquot and a first staining dye that stains red blood cells, and a second measurement sample by mixing the second aliquot and a second staining dye that stains nucleic acids. The measurement portion measures fluorescence emitted from the first measurement sample prepared by the sample preparing portion, and fluorescence emitted from the second measurement sample prepared by the sample preparing portion.
    Type: Grant
    Filed: August 27, 2015
    Date of Patent: December 5, 2017
    Assignee: Sysmex Corporation
    Inventors: Masatsugu Ozasa, Kanako Nagaoka, Akinori Kawai, Masanori Kawano
  • Patent number: 9821313
    Abstract: A method and apparatus for opening a reaction vessel having a body forming a volume for liquid, and a lid. In the method at least one reaction vessel is placed on a transport vehicle and the reaction vessel is positioned on the vehicle so that the vessel's rotation about its own axis is prevented. Then, the at least one reaction vessel is transferred on the vehicle and a guide rod, attached to the lid that is attached by a hinge to the reaction vessel, is pushed by the movement of the vehicle against a guide surface that forces the lid to turn on the hinge so that the lid is at least partially opened.
    Type: Grant
    Filed: October 28, 2011
    Date of Patent: November 21, 2017
    Assignee: Thermo Fisher Scientific Oy
    Inventors: Vesa Nuotio, Juhani Siidorov, Sami Kukkonen
  • Patent number: 9821306
    Abstract: The present invention is directed generally to devices and methods for manipulating laboratory pipettes in a programmable manner. The present invention is directed to an apparatus and methods for allowing a user to instruct the device to perform a specific process; identifying the type, location and identity of the consumables to be used; manipulating a plurality of pipettes for performing the liquid handling; monitoring the process during and after its execution; generating a detailed report for the plurality of actions. Other aspects of this invention include optimization of the liquid dispensing performances of a pipette; monitoring and controlling individual actions by means of vision; virtualization of the protocol definition by means of a reality augmented software interface; integration of the system in a conventional laboratory environment workflow.
    Type: Grant
    Filed: November 22, 2011
    Date of Patent: November 21, 2017
    Assignee: Andrew Alliance S.A.
    Inventors: Piero Zucchelli, Giorgio Horak, Antoine Jordan
  • Patent number: 9816758
    Abstract: An integrated heater assembly (190) is operable to provide a supply of solution from a tank (200). The assembly (190) includes a head arrangement (290) for mounting onto a hole of the tank (200), and a heating element (210) for selectively warming the solution in the tank (200), wherein the heating element (210) includes a duct through which fluid for heating the solution is operable to flow, and wherein the head arrangement (290) includes a valve (220) for controlling flow of the fluid within the duct. The valve (220) is optionally retained in a snap-fit manner within a plastics material moulding of the head arrangement (290). Moreover, the valve (220) is optionally an electromagnetic solenoid valve. The assembly (109) is beneficially adapted for coping with urea solution in the tank (200).
    Type: Grant
    Filed: March 16, 2010
    Date of Patent: November 14, 2017
    Assignee: Wema As
    Inventor: Øystein Gismervik
  • Patent number: 9817010
    Abstract: A clinical diagnostic sample analyzer for analyzing a sample of a patient is disclosed. The analyzer includes a telescoping closed-tube sampling assembly with a sample probe concentrically housed within a piercing probe and a venting mechanism. The closed-tube sampling assembly is used for aspirating a sample from a sample tube for analysis by a clinical diagnostic sample analyzer.
    Type: Grant
    Filed: May 8, 2014
    Date of Patent: November 14, 2017
    Assignee: Instrumentation Laboratory Company
    Inventors: Matthew Blouin, Gregory Murphy, Diana Mackenzie, Alan Weeks, Daniel Kobrenski