Sample Mechanical Transport Means In Or For Automated Analytical System Patents (Class 422/63)
  • Patent number: 11446618
    Abstract: A system for on-site production of chlorine dioxide and other sanitizing solutions is disclosed which includes a controller for measuring fluids into a measuring/mixing vessel. The measuring/mixing vessel is designed to measure and mix water with activator and base additives to create a ready-to-use cleaning solution. A drainage system is employed to transfer the ready-to-use cleaning solution into a reservoir for on-site use.
    Type: Grant
    Filed: October 2, 2019
    Date of Patent: September 20, 2022
    Inventors: Robertus T. Krijnen, Michael C. Pawlak
  • Patent number: 11422073
    Abstract: Various examples of systems and methods are provided for slide processing. In one example, among others, a system for processing microscope slides includes a slide positioner that can adjust a position of a slide and a slide treatment system that can dispense a micro stream of a fluid at a location on the slide when the slide is positioned beneath a jet nozzle of the slide treatment system. The system can include a slide sled that can align a smearing slide with a surface of the slide including a fluid sample is disposed, and support the smearing slide at a predefined angle with respect to the surface of the slide. In another example, a method includes obtaining a slide including a sample disposed on a surface, positioning the slide below to a jet nozzle, and dispensing a micro stream of a fluid onto the sample using the jet nozzle.
    Type: Grant
    Filed: January 4, 2019
    Date of Patent: August 23, 2022
    Inventor: William Eugene Campbell
  • Patent number: 11406981
    Abstract: Automated test instruments electronically determine and/or obtain cell availability of cells of a holding structure in an incubated test chamber and for each of a plurality of open and available cells and electronically identify neighboring cells, electronically determining whether each of the identified neighboring cells are occupied or empty and, if occupied, electronically evaluating at least one of a test status or a time from load of a specimen container held therein. The instruments then electronically rank each of the plurality of open and available cells based at least in part on whether the identified neighboring cells are occupied or empty and the at least one of test status or time from load of the occupied cells of the identified neighboring cells. The loading mechanism is then directed to load an incoming specimen container into a selected one of the open and available cells based on the ranking.
    Type: Grant
    Filed: August 21, 2019
    Date of Patent: August 9, 2022
    Assignee: BIOMERIEUX, INC.
    Inventors: Michael Edmiston, Jonathan Elenkiwich, Warren Vincent
  • Patent number: 11391654
    Abstract: Disclosed is a device for contactlessly mixing fluid present on the upper surface of the slide, where the device comprises a first nozzle array and a second nozzle array, the first nozzle array adapted to impart a bulk fluid flow to the fluid present on the upper surface of the slide, and the second nozzle array adapted to impart at least a first regional fluid flow to at least a portion of the fluid present on the upper surface of the slide.
    Type: Grant
    Filed: May 19, 2020
    Date of Patent: July 19, 2022
    Assignee: Ventana Medical Systems, Inc.
    Inventor: Nathaniel Crum
  • Patent number: 11360108
    Abstract: It is necessary to dispose a plurality of units which have different target temperatures on an apparatus in a more integrated state in order to improve analysis performance and processing capacity per unit space of the apparatus. Therefore, it is necessary to mitigate influence of temperature exerted between units. It is possible to reduce the temperature influence exerted between the units and thus efficiently control temperature by properly disposing the units in the apparatus, based on the relationship between a use environment temperature of the apparatus and a target temperature of each unit and temperature accuracy required for the unit.
    Type: Grant
    Filed: January 18, 2018
    Date of Patent: June 14, 2022
    Assignee: HITACHI HIGH-TECH CORPORATION
    Inventors: Takenori Okusa, Yoshihiro Yamashita, Shunsuke Sasaki
  • Patent number: 11360111
    Abstract: Provided is a connection module with a high degree of freedom for an automatic analyzer which does not depend on a device as a discharge destination. For this purpose, a module to be connected to an automatic analyzer with a rack rotor mechanism includes: a rack discharge mechanism for moving a rack from the rack rotor mechanism to a rotation holder; a rack rotating mechanism for rotating the rack moved to the rotation holder; a conveyor mechanism for transporting the rack from the rack rotating mechanism to a discharge port; and a feeder mechanism for pushing the rack out of the rotation holder to the conveyor mechanism, in which the rack rotating mechanism rotates the rotation holder from a direction parallel to the rack discharge mechanism to a direction parallel to the feeder mechanism and the conveyor mechanism in the selected rotation direction.
    Type: Grant
    Filed: August 23, 2018
    Date of Patent: June 14, 2022
    Assignee: HITACHI HIGH-TECH CORPORATION
    Inventors: Yudai Fukushi, Takamichi Mori
  • Patent number: 11360107
    Abstract: Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.
    Type: Grant
    Filed: February 25, 2015
    Date of Patent: June 14, 2022
    Assignee: Labrador Diagnostics LLC
    Inventors: Daniel Young, Samartha Anekal, Elizabeth A. Holmes, Timothy Smith, Chinmay Pangarkar, James R. Wasson
  • Patent number: 11353472
    Abstract: Automated analyzer (2000) comprising a housing (2010, 3010), a robotic arm comprising an end effector (2360), the end effector (2360) comprising a body (2320) rotatably connected to an articulating arm and first (2363a) and second fingers (2363b) coupled to the body (2362) and being moveable relative to each other in a first direction, each of the fingers (2363a, b) having an engagement feature (2361) projecting inwardly from each of the first and second fingers (2363a, b) and toward the other of the first and second fingers (2363a, b). The automated analyzer (2000) further comprises a shuttle platform (2030) for receiving a shuttle (2030) carrying sample containers (03), the containers carrying sample (03) to be evaluated by the analyzer (2000) and the shuttle platform (2030) comprising a jaw assembly that engages the bottom portion of the sample containers when the jaw assembly is in the closed position.
    Type: Grant
    Filed: February 17, 2017
    Date of Patent: June 7, 2022
    Assignee: BECTON DICKINSON AND COMPANY
    Inventors: Michael T. VanSickler, Brian Austin Self, Alyssa Shedlosky, Joel Daniel Krayer
  • Patent number: 11327090
    Abstract: In example implementations, a method is provided. The method may be executed by a processor of a fluid dispensing apparatus. The method includes dispensing a fluid onto a surface from a dispenser during an alignment procedure. The surface is ejected for alignment verification. The surface is then received for re-execution of the alignment procedure after the alignment verification. The dispenser is re-used to dispense fluid onto the surface during re-execution of the alignment procedure.
    Type: Grant
    Filed: September 27, 2017
    Date of Patent: May 10, 2022
    Assignee: Hewlett-Packard Development Company, L.P.
    Inventors: David H. Ochs, Kenneth Ward
  • Patent number: 11327070
    Abstract: The present disclosure provided a blood cell analyzer, a control device and a blood analysis method thereof. In the method, a first reagent is mixed with a sample to obtain a first testing sample, and then a second reagent is mixed with the first testing sample for a further reaction to get a second testing sample for basophil classification and/or HGB measurement. A blood sample may be tested in one reaction cell through time-division multiplexing technology to obtain four groups leukocytes classification result and HGB result by single detection channel. Thus, the structure of the analyzer may be greatly simplified on the premise of guaranteeing the performance of the analyzer, the size and cost of the analyzer may reduce and a performance-price ratio of the analyzer may increase.
    Type: Grant
    Filed: February 15, 2019
    Date of Patent: May 10, 2022
    Assignee: Shenzhen Mindray Bio-Medical Electronics Co., Ltd.
    Inventors: Wenjun Tong, Yijie Yang, Huaming Xu, Xing Shi
  • Patent number: 11307213
    Abstract: A specimen processing apparatus may include: an aspirating tube configured to aspirates a specimen in automatic aspiration and manual aspiration; an aspirating tube moving mechanism configured to move the aspirating tube between a first region in which the automatic aspiration is performed and a second region in which the manual aspiration is performed, the first region covered with a wall, the second region separated from the first region; and a processing unit that processes the specimen aspirated by the aspirating tube.
    Type: Grant
    Filed: May 22, 2018
    Date of Patent: April 19, 2022
    Assignee: SYSMEX CORPORATION
    Inventor: Yuuichi Hamada
  • Patent number: 11293416
    Abstract: The present disclosure provides generally for a fluid-dispensing device. More specifically, the present disclosure provides for a precision fluid-dispensing device that may deliver a predefined volume of fluid quickly and reliably. In some aspects, the precision fluid-dispensing device may be used to deliver a fluid to a receiving container, such as in a manufacturing line, as a non-limiting example. In some embodiments, the precision fluid-dispensing device may dispense very accurate volumes of fluid using the head pressure of the fluid from an elevated reservoir or pressurized fluid supply. In some implementations, the precision fluid-dispensing device may dispense fluid gently and quickly, which may allow for handling of fluids that may be sensitive to agitation or mixing.
    Type: Grant
    Filed: September 20, 2018
    Date of Patent: April 5, 2022
    Assignees: Hartmann's, Inc., Duncanetics, LLC
    Inventors: Michael Alan Hartmann, David Duncan
  • Patent number: 11285479
    Abstract: Devices and methods for handling liquids are provided. The devices and methods make use of specifically controlled centrifugal forces to drive liquid flow between two cavities connected by a conduit such that as liquid flows into the second cavity, a gas volume is trapped in the second cavity and a pressure of the gas increases, allowing for pneumatic control of liquid flow. The devices and methods facilitate one or more of the mixing, metering and sequencing of liquids, for example on a microfluidic device.
    Type: Grant
    Filed: June 20, 2019
    Date of Patent: March 29, 2022
    Assignee: Biosurfit S.A.
    Inventors: Tania Moura Pires De Andrade Tenreiro, Luis Miguel Dias Martins, Fábio Miguel Rolo Pereira, Nuno Alexandre Esteves Reis
  • Patent number: 11280709
    Abstract: A coverslipping machine (1) is embodied to be connected to an electrical power grid in order to be supplied with electrical energy as an electrical load; and removes specimen slides (4), having samples present thereon, from a specimen slide magazine (5) and respectively carries out a coverslipping process in which a mounting medium (7) and then a coverslip (8) are applied onto each specimen slide (4); and deposits the coverslipped specimen slides (4) in the specimen slide magazine (5) or in a further specimen slide magazine (55). The coverslipping machine (1) has an electrical energy reservoir (12) and an electronic control apparatus (13).
    Type: Grant
    Filed: February 25, 2019
    Date of Patent: March 22, 2022
    Assignee: Leica Biosystems Nussloch GmbH
    Inventors: Benjamin Siehl, Markus Sharpe, Markus Wittmann
  • Patent number: 11280733
    Abstract: An automatic analyzer that allows appropriate setting of analytical parameters which incorporate batch-to-batch variations in reagents. The analytical parameters consist of fixed parameters and variable parameters. The fixed parameters include a reagent-dispensing quantity, a sample-dispensing quantity, measuring wavelength, and the like, each of which becomes a pivot for measurement of a sample, and parameters to be used are selected from an item code and bottle code assigned to a reagent bottle. The variable parameters include a linearity check value, a prozone check value, reaction limit absorbance, technical limits, first standard solution absorbance, variation allowable absorbance, and the like, each of which is associated with sample-measurement result checks. The automatic analyzer reads bar code information from the reagent bottle and adopts variable parameters of a corresponding version with the item code, the bottle code, and batch information relating to the reagent, as a key.
    Type: Grant
    Filed: November 9, 2017
    Date of Patent: March 22, 2022
    Assignee: HITACHI HIGH-TECH CORPORATION
    Inventors: Kumiko Kamihara, Tomonori Mimura
  • Patent number: 11268971
    Abstract: An automated analyzer is provided with one or more dispensing lines 109, 209 that are each for loading and unloading, at one end thereof, a sample rack 101 having placed therein one or more sample containers accommodating a sample for analysis and for conveying the sample rack back and forth from a dispensing position for dispensing the sample from the sample containers and sample rack removal parts 111, 211 that are provided adjacent to the other ends of the dispensing lines 109, 209 and provide and receive sample racks to and from the dispensing lines 109, 209. According to this configuration, it is possible to convey an urgent sample while suppressing device complexity, preventing cost from increasing, and also maintaining speed.
    Type: Grant
    Filed: January 31, 2018
    Date of Patent: March 8, 2022
    Assignee: HITACHI HIGH-TECH CORPORATION
    Inventors: Akihisa Makino, Masashi Akutsu, Hiroyuki Mishima, Akihiro Yasui
  • Patent number: 11249297
    Abstract: An image acquisition device includes a cassette mounting unit in which a cassette is detachably mounted, the cassette holding the slide glasses in a plurality of stages in a predetermined arrangement direction, a light source that emits inspection light toward the cassette, a scanning unit that performs scanning with the inspection light in the arrangement direction, a light reflection unit that is disposed on the back surface side of the cassette and reflects the inspection light emitted from the light source, a light detection unit that detects reflected light including the inspection light reflected by at least one of the light reflection unit, the cassette, and the slide glass, and outputs a detection signal, and an information generation unit that generates holding information on a holding position and/or a holding state of the slide glass held in the cassette on the basis of the detection signal.
    Type: Grant
    Filed: March 12, 2018
    Date of Patent: February 15, 2022
    Assignee: HAMAMATSU PHOTONICS K.K.
    Inventors: Takeshi Shibata, Yasumoto Suzuki, Takayuki Kawashima, Satoshi Watanabe
  • Patent number: 11215609
    Abstract: The present disclosure provided a blood cell analyzer, a control device and a blood analysis method thereof. In the method, a first reagent is mixed with a sample to obtain a first testing sample, and then a second reagent is mixed with the first testing sample for a further reaction to get a second testing sample for basophil classification and/or HGB measurement. A blood sample may be tested in one reaction cell through time-division multiplexing technology to obtain four groups leukocytes classification result and HGB result by single detection channel. Thus, the structure of the analyzer may be greatly simplified on the premise of guaranteeing the performance of the analyzer, the size and cost of the analyzer may reduce and a performance-price ratio of the analyzer may increase.
    Type: Grant
    Filed: February 15, 2019
    Date of Patent: January 4, 2022
    Assignees: CHENGDU SHEN MIDRAY MEDICAL ELECTRONICS TECHNOLOGY RESEARCH INSTITUTE CO., LTD, SHENZHEN MINDRAY BIO-MEDICAL ELECTRONICS CO., LTD.
    Inventors: Wenjun Tong, Yijie Yang, Huaming Xu, Xing Shi
  • Patent number: 11213818
    Abstract: Various embodiments herein disclose a device, comprising one or more fluid interfacing components and a cartridge holder, wherein the one or more fluid interfacing components are fixed while the cartridge holder moves along a linear guide. Also disclosed herein are methods of using the device to analyze a sample containing particles, and methods of diagnosing a disease in a subject by using the device.
    Type: Grant
    Filed: November 22, 2016
    Date of Patent: January 4, 2022
    Assignee: Spectradyne LLC
    Inventors: Andrew N. Cleland, Jean-Luc Fraikin, Peter Meinhold, Franklin Monzon
  • Patent number: 11204360
    Abstract: A switch for a conveying line for transporting a laboratory diagnostic vessel carrier is presented. The conveying line comprises a first line portion and a second line portion. The switch comprises a curved first guiding surface and a second guiding surface. The switch is moveable between a first position, in which the laboratory diagnostic vessel carrier is transportable along the curved first guiding surface from the first line portion to the second line portion, and a second position, in which the laboratory diagnostic vessel carrier is further transportable along the second guiding surface on the first line portion. A switch assembly and a conveying line are also disclosed.
    Type: Grant
    Filed: June 1, 2018
    Date of Patent: December 21, 2021
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: David Huber, Daniel Arnold
  • Patent number: 11193875
    Abstract: A method for identifying, analyzing, and quantifying the cellular components of whole blood by means of an automated hematology analyzer and the detection of the light scattered, absorbed, and fluorescently emitted by each cell. More particularly, the aforementioned method involves identifying, analyzing, and quantifying the cellular components of whole blood by means of a light source having a wavelength ranging from about 400 nm to about 450 nm and multiple in-flow optical measurements and staining without the need for lysing red blood cells.
    Type: Grant
    Filed: April 28, 2017
    Date of Patent: December 7, 2021
    Assignee: Abbott Laboratories
    Inventors: Martin Krockenberger, Jiong Wu, Bodo Roemer, Giacomo Vacca
  • Patent number: 11188095
    Abstract: Systems and methods for sending scheduling information to a mobile robotic device from an application of a communication device. The application of the communication device generates at least one scheduling command and transmits the at least one scheduling command to a router using a first wireless communication channel. The router is configured to transmit and receive the at least one scheduling command to and from at least one cloud service. A charging station of the robotic device receives the at least one scheduling command from the router using the first wireless communication channel and stores the at least one scheduling command on the charging station. The charging station transmits the at least one scheduling command to a processor of the robotic device using a second wireless communication channel and the processor of the robotic device modifies its scheduling information based on the at least one scheduling command.
    Type: Grant
    Filed: July 31, 2018
    Date of Patent: November 30, 2021
    Assignee: AI Incorporated
    Inventors: Chin Pang Alfred Kwan, Andrew Francis Fitzgerald, Ali Ebrahimi Afrouzi
  • Patent number: 11185865
    Abstract: Systems and methods for refrigerated storage of controls and calibrators utilize a refrigerant storage assembly having an insulated housing and door assembly, thermoelectric coolers, and the refrigerated base assembly having a metal plate thermally coupled to coolers, one or more sensors, and a plurality of receptacles to receive fluid tubes. Refrigerated storage provides a refrigerated environment suitable for multi-day storage of control and calibrator fluids.
    Type: Grant
    Filed: July 19, 2017
    Date of Patent: November 30, 2021
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Ryan German, Colin Mellars
  • Patent number: 11169165
    Abstract: Disclosed are high-throughput vessel supply systems and methods of supplying sample vessels, such as samples stored in test tubes. A system for supplying a plurality of individual vessels that each contains a sample is disclosed.
    Type: Grant
    Filed: January 31, 2019
    Date of Patent: November 9, 2021
    Assignee: Laboratory Corporation of America Holdings
    Inventors: David Wilson, Jay Krajewski, Kevin Meyer
  • Patent number: 11169163
    Abstract: A method for performing flexible liquid handling processes among a plurality of consumables includes moving consumables by at least one arm having a magnetic interface device, connecting the at least one arm from the consumables, based on magnetic attraction utilizing said magnetic interface device, and aspirating and dispensing liquids on the consumables by at least one static or quasi-static pipette. The aspiration and dispensing actions are performed without displacement of the pipettes. The method further includes sensing, by the at least one arm, magnetic presence of a matching consumable connector or magnetic vector field modified by a presence of a matching consumable connector. The method includes disconnecting the at least one arm from the consumables based on a repulsive magnetic force.
    Type: Grant
    Filed: April 14, 2017
    Date of Patent: November 9, 2021
    Assignee: ANDREW ALLIANCE S.A.
    Inventor: Piero Zucchelli
  • Patent number: 11169073
    Abstract: The disclosure provides example rinse station apparatus, cartridges, and methods for flow cytometry. The rinse station apparatus includes: (a) a cartridge docking station having a base with a recessed receptacle for a cartridge, a vertical support coupled to the base's first end and a top support coupled to the vertical support and cantilevered over the base, the top support has an opening that aligns with the cartridge's opening, (b) a locking arm coupled to the base's second end, the locking arm's free end has a ridge to cooperate with a detent coupled to the cartridge's rear wall to retain the cartridge in place, (c) a spring coupled to the vertical support's front face to apply force to the cartridge's front wall to bias the cartridge toward the locking arm, and (d) a load cell coupled to the base of the cartridge docking station, the load cell measure's the cartridge's weight.
    Type: Grant
    Filed: May 24, 2019
    Date of Patent: November 9, 2021
    Assignee: Essen Instruments, Inc.
    Inventors: Stephen Barnes, Zachary Kane, Richard Bennett, Jason Barrett
  • Patent number: 11162946
    Abstract: Methods, devices, and systems for analyzing biological samples are provided. A biological sample may be analyzed for the presence of an analyte by an initial assay, and the performance of, or method of performance of, a subsequent assay may be contingent upon the results of the initial assay. For example, the following may be contingent on the results of a prior assay: whether or not a subsequent assay is performed; which subsequent assay is performed; the method of performing a subsequent assay; the order of performance of a sequence of subsequent assays; the steps, or order of steps, performed in a subsequent assay; the timing of the performance of a subsequent assay; the choice of a reagent used in a subsequent assay; the detection method used in a subsequent assay; and other particulars of assays may be contingent on the results of a prior assay.
    Type: Grant
    Filed: September 15, 2015
    Date of Patent: November 2, 2021
    Assignee: Labrador Diagnostics LLC
    Inventors: Daniel Young, Elizabeth A. Holmes
  • Patent number: 11156597
    Abstract: A urine testing device and a smart toilet having the urine testing device, which includes a base, a paper feeding module, a sample adding module, and a testing module installed on the base and arranged in a linear form. The paper feeding module has a test paper box, a lifting mechanism, and a pushing mechanism. A horizontal paper leakage groove is disposed at a bottom of the test paper box to receive a bottommost piece of test paper. The lifting mechanism lifts and descends the test paper box to reveal/seal the paper leakage groove. The pushing mechanism pushes out test paper from the paper leakage groove and delivers test paper to the sample adding and testing modules. The sample adding module dropwise adds urine to be tested on test paper. The testing module tests test paper added with the sample to obtain a urine testing result.
    Type: Grant
    Filed: October 25, 2016
    Date of Patent: October 26, 2021
    Assignee: Shanghai Kohler Electronics, Ltd.
    Inventor: Zhiyu Qin
  • Patent number: 11112419
    Abstract: A laboratory distribution system is presented. The system comprises diagnostic laboratory container carriers and a conveyor. The conveyor comprises an endless drive defining a closed-loop conveyor pathway. The system comprises supporting elements attached to the endless drive. The supporting elements receive a container carrier and transport the container carrier in an upright position along a pathway section. The supporting elements are mounted pivotally about a horizontal pivot axis to the drive and structured such that a center of gravity of the supporting element with or without an empty or loaded container carrier is arranged below and vertically aligned with the pivot axis when the supporting element is in an upright position such that each supporting element is free to pivot about the associated pivot axis under the effect of gravitational forces acting on the supporting element for maintaining the supporting elements in an upright position while travelling along the path.
    Type: Grant
    Filed: July 10, 2018
    Date of Patent: September 7, 2021
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Hans van Mierlo, Gottlieb Schacher, Marcel Kaeppeli, Reto Huesser, Andreas Drechsler, Matthias Goetz, Nenad Milicevic
  • Patent number: 11099201
    Abstract: The invention relates to a device (1) for the automated analysis of solids or fluids. Said device comprises a first station (5) having a metering unit (51) for the filling of at least one sample chamber (2) with a specified sample quantity, a second station (6) having at least one measurement device (61) for an analysis of the sample situated in a sample chamber (2) and a third station (7) having an emptying device and cleaning device (71, 72) for the at least one sample chamber (2). Moreover, there is provided a transport device (3) for a revolving transport of the at least one sample chamber (2) from one station to the next until the first station (5) is reached again. According to the invention, the measurement device (61) of the second station (6) is a spherical measurement system, through the interior of which it is possible to guide the at least one sample chamber (2).
    Type: Grant
    Filed: October 12, 2016
    Date of Patent: August 24, 2021
    Assignee: Blue Ocean Nova AG
    Inventor: Joachim Mannhardt
  • Patent number: 11085914
    Abstract: A hematology analyzer is provided. In certain embodiments, the hematology analyzer comprises: a) a flow cell; b) a light source for directing light to the flow cell; c) a plurality of detectors for detecting a plurality of optical characteristics of a blood cell passing through the flow cell; and d) a data analysis workstation programmed to: i. enumerate test blood cells passing through the flow cell; and ii. flag a blood sample as containing lysis-resistant red blood cells or fragile white blood cells.
    Type: Grant
    Filed: April 3, 2017
    Date of Patent: August 10, 2021
    Assignee: Abbott Laboratories
    Inventors: Martin Krockenberger, Richard Bordenkircher, Diana Garrett, John Glazier, James Bearden, Bodo Roemer, Giacomo Vacca
  • Patent number: 11085940
    Abstract: The automatic analyzer includes a sample storage section for accommodating a plurality of samples, a reagent storage section for accommodating a plurality of reagents, an analysis section for carrying out an analysis by reacting the sample with the reagent, a display, a storage section for storing a setting of an operation item to be automatically executed, which is effective only at restarting, and a control section which displays a screen for setting the operation item to be automatically executed upon acceptance of power shutdown operation by an operator during the analysis on the display to accept the setting from the operator, and automatically executes or omits execution of the operation item to be automatically executed, which has been set by the operator in accordance with the setting read from the storage section at the restarting.
    Type: Grant
    Filed: July 11, 2016
    Date of Patent: August 10, 2021
    Assignee: HITACHI HIGH-TECH CORPORATION
    Inventor: Takayuki Noda
  • Patent number: 11059675
    Abstract: The present invention is directed to a system and method for transferring specimen containers between detection instruments. The method may include transporting a specimen container in a locator well to a container transfer station in a first automated detection apparatus; sensing the specimen container at the container transfer station using a first sensor; transferring the specimen container from the container transfer station of the first automated microbial detection apparatus to an automated loading mechanism of a second automated microbial detection apparatus; detecting that the specimen container is positioned over the automated loading mechanism of the second automated microbial detection apparatus using a second sensor; and releasing the specimen container onto the automated loading mechanism of the second automated microbial detection apparatus.
    Type: Grant
    Filed: October 18, 2019
    Date of Patent: July 13, 2021
    Assignee: bioMérieux, Inc.
    Inventors: Thierry Vivet, Michael Belgeri, Walter Clynes
  • Patent number: 11034929
    Abstract: Aspects of the present invention relate to an automated cell culture instrument and to methods for operating such an instrument. In one aspect, the cell culture instrument includes a computing unit and a plurality of electrically controllable resources (e.g., sensors, actuators, etc.). The computing unit receives a protocol, schedules the resources so as to execute the protocol, and operates the resources as scheduled or in response to so as to provide an improved environment for cell culture growth. The computing unit may simulate protocol execution in connection with the scheduling or execution of the protocol.
    Type: Grant
    Filed: November 18, 2016
    Date of Patent: June 15, 2021
    Assignee: Thrive Bioscience, Inc.
    Inventors: Howard Cannon, Keith Moulton
  • Patent number: 11024998
    Abstract: A kit which has a first and second component parts, which are adapted for connection with each other. The first component part has a first array of electrical sensors, two substantially parallel lateral walls on the sides of the electrical connectors, two rails extending along the sides of the array, a front contact point and an overhang for receiving the second part. The second component part has a second array of electrical sensors for connection to the first array, front end configured to fit between the lateral walls of the first connector, and lateral sides having rail reliefs to fit the rails of the first connector. Connection of the first component part and the second component part forms a shoulder that aligns to locate the second array of electrical connectors in correct position for connection to the first array of electrical connectors.
    Type: Grant
    Filed: September 28, 2017
    Date of Patent: June 1, 2021
    Assignee: Oxford Nanopore Technologies Ltd.
    Inventors: David Waterman, Richard Smith
  • Patent number: 11016008
    Abstract: An analysis instrument may perform analytical operations on an analyte that is combined with multiple reagents prior to being introduced into a flow cell. The instrument may include a nozzle sipper that aspirates reagents from a recipient, along with an analyte. The reagents may be directed to a volume and may be repeatedly moved into and out of the volume by cycling of a pump. The reagents may be ejected into a destination recipient with the nozzle sipper promoting vorticity in the recipient to enhance mixing. The repeated aspiration and ejection through the nozzle sipper effectively mixes the reagents and the template in an automated or semi-automated fashion.
    Type: Grant
    Filed: December 13, 2017
    Date of Patent: May 25, 2021
    Assignee: ILLUMINA, INC.
    Inventors: Bradley Kent Drews, Michael Dai Wang, Umberto Ulmanella, James Michael Osmus, Stephen Wayne Clark, Johanna Lynn Whitacre, Steven Scott Phelps, Michelle L. Alvarez, Michael Adalbert Niziolek, Debra Sue Bryan, Joshua Augustin Darland
  • Patent number: 10972641
    Abstract: The present invention provides, among other thing, devices and methods for simple, fast, and sensitive assaying, including imaging.
    Type: Grant
    Filed: February 8, 2018
    Date of Patent: April 6, 2021
    Assignee: Essenlix Corporation
    Inventors: Stephen Y. Chou, Wei Ding, Yufan Zhang, Ji Qi, Jun Tian, Wei Dong
  • Patent number: 10933415
    Abstract: An analysis container comprises a main body; a first chamber that is provided inside the main body and holds a liquid sample; a second chamber; a liquid passage; and an air passage. The liquid passage connects the first chamber and the second chamber, and moves the liquid sample from the first chamber to the second chamber. The air flow chamber connects the first chamber and the second chamber, and moves air from the second chamber to the first chamber.
    Type: Grant
    Filed: August 10, 2016
    Date of Patent: March 2, 2021
    Assignee: PHC HOLDINGS CORPORATION
    Inventors: Masahiro Kouge, Fumiya Matsubara
  • Patent number: 10919399
    Abstract: A vehicle system provided according to one aspect of the present disclosure includes a power transmitter and a vehicle. The power transmitter is placed at one of at least one charge position. The vehicle includes: a power receiver, a capacitor, and a motor. The power receiver wirelessly receives first electric power from the power transmitter, and outputs second electric power deriving from the first electric power. The capacitor stores the second electric power output by the power receiver such that the capacitor is charged from a first voltage Vc1 to a second voltage Vc2. The motor is driven by the second electric power from the capacitor. The vehicle automatically travels a distance Dx along a route from one to a next one of the at least one charge position on the route. The distance Dx satisfies a certain relationship.
    Type: Grant
    Filed: April 28, 2017
    Date of Patent: February 16, 2021
    Assignee: DAIHEN Corporation
    Inventors: Hiroyuki Kotani, Masao Yokota
  • Patent number: 10907129
    Abstract: An apparatus and a method for the automated processing of samples containing biological cells—in particular, of blood samples or other cell samples is provided. The apparatus has a sample receiving device configured to receive samples, an auxiliary material receiving device configured to receive auxiliary materials, a sample carrier receiving device configured to receive sample carriers, a discharge device configured to discharge samples from a discharge position, and a capture device configured to capture discharged samples in a capture position to obtain prepared samples, and at least one temperature control device for controlling the temperature of at least one of the sample carriers. The distance between the discharge position and the capture position can be adjusted to a prespecified height. The method includes wetting a temperature-controlled sample carrier with at least one auxiliary material and discharging the sample onto the wetted temperature-controlled sample carrier from a prespecified height.
    Type: Grant
    Filed: April 28, 2019
    Date of Patent: February 2, 2021
    Assignee: ALS Automated Lab Solutions GmbH
    Inventors: Matthias Opel, David Unglaub, Jens Eberhardt, Gerd Bornmann
  • Patent number: 10900875
    Abstract: An automated system for processing a sample contained in a liquid sample container includes an automated tool head configured to rotate about a first axis, and to translate along a second axis different than the first axis, an analytic element positioner having an analytic element holder configured to releasably grip an analytic element, and a specimen transfer device carried by the tool head, wherein the tool head is configured to automatically position a working end of the specimen transfer device to obtain a specimen from a sample container held in the sample container holder, and to transfer the obtained specimen to an analytic element held by the analytic element holder, respectively, through one or both of rotation of the tool head about the first axis and translation of the tool head along the second axis.
    Type: Grant
    Filed: March 9, 2018
    Date of Patent: January 26, 2021
    Assignee: Hologic, Inc.
    Inventors: Barry F. Hunt, Raymond Jenoski, Ryan Oliva, Michael Cordeiro, Eric Grimes
  • Patent number: 10889002
    Abstract: Systems, methods, and related technologies are disclosed for multi-device robot control. In one implementation, input(s) are received and provided to a personal assistant or another application or service. In response, command(s) directed to an external device are received, e.g., from the personal assistant. Based on the command(s), a robot is maneuvered in relation to a location associated with the external device. Transmission of instruction(s) from the robot to the external device is initiated.
    Type: Grant
    Filed: January 20, 2020
    Date of Patent: January 12, 2021
    Assignee: X-Tend Robotics Inc.
    Inventors: Gavriel Krauss, Harry Fox
  • Patent number: 10882008
    Abstract: An apparatus for processing biological sample is provided, which comprises a semi-permeable membrane column, an adaptor column and a vacuum manifold. The at least one semi-permeable membrane column is configured for accommodating biological sample therein and comprises a curved surface. The at least one adaptor column is configured for accommodating the semi-permeable membrane column therein and comprises a stopping element. The vacuum manifold is configured for creating a vacuum that facilitates flowing of the biological sample into the semi-permeable membrane column through a semi-permeable membrane therein. The stopping element abuts against the curved surface.
    Type: Grant
    Filed: February 2, 2018
    Date of Patent: January 5, 2021
    Assignee: TAIGEN BIOSCIENCE CORPORATION
    Inventor: Chi-Sheng Tai
  • Patent number: 10880468
    Abstract: A metrology system is provided with a transparent workpiece surface mode, for which the system is configured to vary a focus position over a plurality of positions along a Z height direction proximate to a workpiece. An image stack is acquired, wherein each image of the image stack includes a first surface (e.g., an upper surface of the workpiece) that is transparent or semi-transparent and at least a second surface that is at least partially viewable through the first surface. A plurality of focus curves are determined based on the image stack (e.g., with pattern projection utilized for improved contrast), from which first, second, etc. local focus peaks may be determined from each focus curve that correspond to the first, second, etc. surfaces, respectively. An image is displayed (e.g., extended depth of field, 3D) including a selected surface and for which features of the selected/displayed surface may be measured.
    Type: Grant
    Filed: December 19, 2019
    Date of Patent: December 29, 2020
    Assignee: Mitutoyo Corporation
    Inventor: Robert Kamil Bryll
  • Patent number: 10871474
    Abstract: Disclosed is a station, for testing an analyte in a sample, enabling accurate and quick reaction and analysis of the sample and a reagent in one apparatus. To this end, the present disclosure provides a station, which is for testing a sample by means of inserting a cuvette, having a standby chamber on which a collecting member is placed, a sample chamber, a reagent chamber and a detection unit. The station comprises: a housing which has an input/output part into which a cuvette is inserted; a driving unit which is provided inside the housing, horizontally moves the cuvette, vertically moves a collecting member, reacts a sample in a sample chamber and a reagent in a reagent chamber, and injects a reaction result thereof into a detection unit; and an optical reader which is provided on the horizontal movement path of the cuvette and is for analyzing the reaction result.
    Type: Grant
    Filed: November 17, 2017
    Date of Patent: December 22, 2020
    Assignee: BODITECH MED INC.
    Inventors: Byeong Chul Kim, Bong Suk Moon, Younghaeng Lee, Ju Hyoung Bang, Nam Chul Ha, Jae Un An
  • Patent number: 10871438
    Abstract: A system, method, and apparatus are provided for flow cytometry. In one example, the flow cytometry system includes dual laser devices and dual scatter channels to measure velocity of particles in a core stream of sample fluid. The total flow rate of the sample fluid and the sheath fluid around the sample fluid is controlled, and thus held constant, by a feedback control system controlling a vacuum pump based on differential pressure across ends of a flow channel in the flow cell. A stepper flow control valves are disclosed that apply a physical fluid resistance to a flow of sheath fluid in the flow cytometer. The physical fluid resistance regulates a flow rate of the sheath fluid and thereby regulates a flow rate of sample fluid in the flow cytometer.
    Type: Grant
    Filed: November 19, 2017
    Date of Patent: December 22, 2020
    Assignee: Cytek Biosciences, Inc.
    Inventor: David Vrane
  • Patent number: 10837977
    Abstract: A rack includes a container holder that is fixed to a stage and holds a container that contains a liquid to be dispensed and a camera that is fixed to the stage and located in a position where the camera is capable of capturing an image of the container.
    Type: Grant
    Filed: May 4, 2016
    Date of Patent: November 17, 2020
    Assignee: KABUSHIKI KAISHA YASKAWA DENKI
    Inventors: Noriko Abe, Yukio Hashiguchi, Makoto Umeno, Hiroshi Kumagai, Yukiko Sawada, Motohisa Kamei
  • Patent number: 10800130
    Abstract: The invention relates to flexible PCM sheet materials having a high latent thermal energy storage density for the purpose of heat management. The flexible PCM sheet material includes a flexible supporting structure and phase-change-material elements arranged thereon separately in a specific geometry. The phase-change-material elements are geometrically defined structures composed of polymer-bound phase-change material. The flexible PCM sheet materials are characterized by a high latent heat storage capacity and optimized thermal conductivity, are dimensionally stable even in the event of temperature changes and after phase transitions, can be rolled, folded, wound, or cut to size without problems, and can be transported, stored, processed, or used in a single layer or in multiple layers.
    Type: Grant
    Filed: May 19, 2015
    Date of Patent: October 13, 2020
    Assignee: smartpolymer GmbH
    Inventors: Dirk Büttner, Angelo Schütz, Martin Geissenhöner
  • Patent number: 10730053
    Abstract: Provided in part herein are static-defeating apparatus for use in multipipettor systems. Multiple pipette tips can be retained by a static-defeating sheet of material. A multipipettor, having multiple pipettes or nozzles, can engage the pipette tips retained by the sheet. After use, the multipipettor can eject the pipette tips, which sometimes are ejected as a single unit due to the pipette tips being retained by the sheet. In certain embodiments, an apparatus includes a snap plate having one or more holes, and a base rack for ease of mounting.
    Type: Grant
    Filed: December 9, 2015
    Date of Patent: August 4, 2020
    Assignee: BIOTIX, INC.
    Inventors: Scott E. Curry, Arta Motadel, Peter Paul Blaszcak
  • Patent number: 10718568
    Abstract: A sample heating device includes: a rail-shaped disposal rail extending in one direction in a horizontal plane so that sample boats after heating are arranged and placed in a straight line; a disposal tray that houses the sample boat pushed-out from one end of the disposal rail; a sample boat conveying portion that places the sample boat after the heating at a predetermined placing position on the disposal rail; and a sample boat push-out portion that is positioned closer to the other end side of the disposal rail than the placing position when the sample boat is placed on the disposal rail and that is displaced toward the one end side of the disposal rail after the sample boat is placed at the placing position to slide the sample boats on the disposal rail toward the one end side.
    Type: Grant
    Filed: January 11, 2018
    Date of Patent: July 21, 2020
    Assignee: SHIMADZU CORPORATION
    Inventor: Akioki Nakamori