Sample Mechanical Transport Means In Or For Automated Analytical System Patents (Class 422/63)
  • Patent number: 12030712
    Abstract: A transport container includes: a bottom member where the transported object is placed; left and right side members disposed beside the bottom member; a handle disposed above the bottom member; left and right lower connecting members interconnecting the bottom member and side members; and left and right upper connecting members interconnecting the side and the handle members, which are respectively interconnected via hinges. When the handle is not lifted, the side members are separated from the bottom member. When the handle is lifted, the side members laterally support the transported object. As for the transport method, with the transported object stacked in the up-down direction, the transport container is installed at an unloading location such that the lower and upper connecting members are laid to be non-parallel to the side member, and the transported object is taken out from the front or rear between the left and right side members.
    Type: Grant
    Filed: July 1, 2020
    Date of Patent: July 9, 2024
    Assignee: HITACHI HIGH-TECH CORPORATION
    Inventors: Junpei Hokari, Tadao Yabuhara
  • Patent number: 12031984
    Abstract: A detection device using a lateral flow strip for detection and a detection method thereof are provided, which relates to the technical field of a detection device using a lateral flow strip. An upper rotor, a middle rotor and a lower rotor are respectively provided with upper paddle(s), middle paddle(s) and lower paddle(s) along respective circumferential directions. Each upper paddle is provided with a test tube with openings at both ends thereof for placing the lateral flow strip. The middle paddle blocks a bottom one of the openings of the test tube. Each lower paddle is provided with a sample tube for placing sample solution. The bottom opening of the test tube is opposite to a top opening of the sample tube up and down.
    Type: Grant
    Filed: October 27, 2021
    Date of Patent: July 9, 2024
    Assignee: CHINA AGRICULTURAL UNIVERSITY
    Inventors: Nan Cheng, Xiaoyun He, Wentao Xu, Kunlun Huang, Yunbo Luo, Qian Zhang, Qingliang Liu
  • Patent number: 12025597
    Abstract: A liquid chromatograph includes a liquid sender that sends a plurality of solvents, a mixer that has an internal capacity for mixing the plurality of solvents sent by the liquid sender, a sample injector that injects a sample into an analysis flow path through which the solvents mixed in the mixer flow as a mobile phase, a separation column provided on the analysis flow path for separating the sample injected by the sample injector to each component, a detector provided downstream of the separation column on the analysis flow path for detecting the components of the sample separated in the separation column, a capacity information storage medium that is attached to the mixer to store information as to the internal capacity of the mixer, configured to read the information stored in the capacity information storage medium to specify the internal capacity of the mixer.
    Type: Grant
    Filed: October 15, 2019
    Date of Patent: July 2, 2024
    Assignee: SHIMADZU CORPORATION
    Inventor: Hiroshi Ohashi
  • Patent number: 12013407
    Abstract: The present invention describes a laboratory system for automatically processing at least one sample container containing a biological sample, the laboratory system comprising a housing; laboratory instrument units for executing processing steps on the biological sample; an input station configured to receive the sample container; a transport means for transport of the sample container from the input station to the laboratory instrument units, and further to an output station; a control unit for determining whether the sample and/or the container is in a condition to be processed by the laboratory instrument units; an input-output station providing an interface between the inside and the outside of the housing; and a workbench on the outside of the housing in front of the input-output station for an operator to be in the position to manipulate the sample and/or the container.
    Type: Grant
    Filed: October 18, 2018
    Date of Patent: June 18, 2024
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Andreas Gisler, Mike Mohns, Vijay Namasivayam, Maren Christin Wolff, Devorah Klein, Tim Moulton, Sam Palmer, Eric Saperstein
  • Patent number: 12011719
    Abstract: In accordance with embodiments herein a method for capturing cells of interest in a digital microfluidic system is provided, comprising utilizing a droplet actuator to transport a sample droplet to a microwell device. The microwell device includes a substrate having a plurality of microwells that open onto a droplet operations surface of the microwell device. The sample droplet includes cells of interest that enter the microwells. The method introduces capture beads to the microwells, and the capture elements are immobilized on the capture beads. The method utilizes the droplet actuator to transport a cell lysis reagent droplet to the microwell device. Portions of the cell lysis reagent droplet enter the microwells and, during an incubation period, cause the cells of interest to release analyte that is captured by the capture elements on the capture beads.
    Type: Grant
    Filed: December 17, 2021
    Date of Patent: June 18, 2024
    Assignee: Illumina, Inc.
    Inventors: Arash Jamshidi, Yan-you Lin, Farnaz Absalan, Sarah Stuart, Gordon Cann, Yir-Shyuan Wu, Tarun Khurana, Jeffrey S Fisher
  • Patent number: 11988682
    Abstract: A transfer system (1) is a transfer system (1) that transfers a sample container (S) containing a sample from a transfer source device (100) to a transfer destination device (200) disposed adjacent to the transfer source device (100), and the transfer system (1) includes an arm (2) having a distal end and a proximal end, the distal end portion facing the transfer destination device (200), and a first catcher (4) for detachably holding the sample container (S) at the distal end, a drive mechanism (14) provided in the transfer source device (100) and configured to drive the arm (2) to move the first catcher (4) between a first position in the transfer source device (100) and a second position in the transfer destination device (200), and a second catcher (16) provided in the transfer destination device (200) and provided so that the sample container (S) is delivered and received between the first catcher (4) and the second catcher (16) when the first catcher (4) reaches the second position.
    Type: Grant
    Filed: December 20, 2021
    Date of Patent: May 21, 2024
    Assignee: SHIMADZU CORPORATION
    Inventors: Katsuhiko Seki, Hikaru Shibata, Hiroyuki Matsumoto
  • Patent number: 11988540
    Abstract: An apparatus includes a probe configured to provide at least a portion of capacitance of an inductance-capacitance (LC) circuit of a detection circuit, the capacitance of the LC circuit being dependent on a distance between the probe and a surface of a liquid in a biochemical analysis system. The apparatus includes a movement mechanism configured to move the probe. The apparatus includes circuitry configured to perform operations that include causing the movement mechanism to move the probe with respect to the liquid; measuring one or more characteristics of an output signal of the detection circuit, the one or more characteristics being dependent on the capacitance of the LC circuit; and detecting, based on the one or more characteristics of the output signal, a contact between the probe and the surface of the liquid.
    Type: Grant
    Filed: August 15, 2022
    Date of Patent: May 21, 2024
    Assignee: Instrumentation Laboratory Co.
    Inventors: Reed Hebert, Benjamin Newton, Len Merrill
  • Patent number: 11987842
    Abstract: A method of preparing reagents includes inserting a cartridge into an instrument. The cartridge includes a plurality of reagent enclosures disposed in a cavity of the cartridge and exposing a port to an exterior of the cartridge. Each reagent enclosure includes a reagent container including a reagent and an internal cavity defining a compressible volume, an opening defined through the reagent container to the internal cavity. The method further includes connecting a plurality of fluid ports to the openings of the plurality of reagent enclosures; applying a solution through the fluid ports to at least partially fill the plurality of reagent enclosures; and cycling a pressure of the cavity, whereby for each of the reagent enclosures, during increasing pressure, the solution enters the internal cavity of the reagent container, combines with the reagent, and compresses the compressible volume, and during decreasing pressure, the compressible volume decreases and the reagent is ejected through the opening.
    Type: Grant
    Filed: January 11, 2021
    Date of Patent: May 21, 2024
    Assignee: Life Technologi s Corporation
    Inventors: Jonathan Schultz, Todd Roswech, Jon A. Hoshizaki, Albert L. Carrillo, James A Ball
  • Patent number: 11971416
    Abstract: An analysis apparatus (1) includes a housing unit (10) that houses a biological sample (S), a staining dispenser unit (20) that fluorescently stains the biological sample (S), an image acquisition unit (30) that acquires an image of the biological sample (S), a washer unit (40) that destains the biological sample (S), a drive unit (50), and a control unit (90) that analyzes the image and controls the drive unit (50). The control unit (90) performs adjustments so that the staining dispenser unit (20) and the housing unit (10) satisfy a first position condition, performs adjustments so that the image acquisition unit (30) and the housing unit (10) satisfy a second position condition, and performs adjustments so that the washer unit (40) and the housing unit (10) satisfy a third position condition. The analysis apparatus (1) maximizes the actual photography range of information related to the biological sample.
    Type: Grant
    Filed: June 9, 2021
    Date of Patent: April 30, 2024
    Assignees: YOKOGAWA ELECTRIC CORPORATION, University of Zurich
    Inventors: Takayuki Kei, Yohei Tsubouchi, Lucas Pelkmans, Gabriele Gut
  • Patent number: 11965884
    Abstract: A method of quantitating free (unbound) human C5 complement protein (C5) from a sample comprising: binding biotinylated anti-C5 capture antibody to strepavidin-coated particles; capturing the free (unbound) C5 in the sample; detecting the captured free C5; and quantitating the captured free C5 using laser-induced fluorescence detection; wherein the method is performed in a Gyros Bioaffy 200 CD in a Gyrolab xPlore or a Gyrolab XP instrument.
    Type: Grant
    Filed: October 19, 2017
    Date of Patent: April 23, 2024
    Assignee: Alexion Pharmaceuticals, Inc.
    Inventors: Mark Dysinger, Mark Ma, Bruce A. Andrien
  • Patent number: 11958736
    Abstract: A water purifier or other liquid dispenser may sense a height of the inlet of a container accurately through an infrared transmitter and an infrared receiver that are disposed at different positions of a water discharge module moving vertically. Additionally, in the water purifier, the water discharge module may discharge purified water at a point spaced a certain distance apart from the inlet of the container, based on infrared sensing, thereby preventing the inlet of the container from contacting the lower surface of the water discharge module.
    Type: Grant
    Filed: April 24, 2023
    Date of Patent: April 16, 2024
    Assignee: LG ELECTRONICS INC.
    Inventors: Jaehoon Lee, Kyuchun Choi, Dong Seong Kim, Daewoo Kim
  • Patent number: 11945239
    Abstract: A method for controlling a printing process by which a print head prints an image onto predetermined printable area of a label.
    Type: Grant
    Filed: August 6, 2021
    Date of Patent: April 2, 2024
    Assignee: GEN-PROBE INCORPORATED
    Inventors: Rolf Silbert, Robert J. Rosati, David Buse, Olev Tammer, Matthias Merten
  • Patent number: 11939570
    Abstract: A microfluidic lab-on-a-chip system for DNA gene assembly that utilizes a DNA symbol library and a DNA linker library. The lab-on-a-chip has a fluidic platform with a plurality of arrays operably connected to a voltage source and a controller for the voltage source, a set of first inlets operably connected to the fluidic platform, each first inlet for one DNA symbol from a DNA symbol library, a set of second inlets operably connected to the fluidic platform, each second inlet for one DNA linker from a DNA linker library, and a mixing area operably connected to the fluidic platform and to the plurality of first inlets and the plurality of second inlets.
    Type: Grant
    Filed: April 23, 2020
    Date of Patent: March 26, 2024
    Assignee: SEAGATE TECHNOLOGY LLC
    Inventors: Tim Rausch, Walter R Eppler, Gemma Mendonsa
  • Patent number: 11933795
    Abstract: A continuous sample introduction method is provided. The method includes controlling a current sample holder advancing mechanism to perform an advancing operation according to a sample introduction trigger signal, so that the current sample holder advancing mechanism moves in a direction from an initial position to a limiting position, and during the movement, a pushing portion of the current sample holder advancing mechanism is capable of abutting against a side wall of a sample holder in a current sample loading device; controlling the current sample holder advancing mechanism to perform a returning operation when the current sample holder advancing mechanism moves to the limiting position, and during the movement, the pushing portion is capable of avoiding contacting with the sample holder; and the current sample holder advancing mechanism automatically repeats the advancing operation and the returning operation when the current sample holder advancing mechanism moves to the initial position.
    Type: Grant
    Filed: December 11, 2020
    Date of Patent: March 19, 2024
    Assignees: SHENZHEN MINDRAY BIO-MEDICAL ELECTRONICS CO., LTD., SHENZHEN MINDRAY SCIENTIFIC CO., LTD.
    Inventors: Yang Zhou, Xianhua Chang, Yang Zhang
  • Patent number: 11908673
    Abstract: An ion molecule reactor for generating analyte ions from analytes comprises: a) a reaction volume in which reagent ions can interact with the analytes in order to form analyte ions; b) at least one analyte inlet for introducing the analytes along an inlet path into the reaction volume whereby, preferably, the inlet path runs essentially along at least a first section of the predefined transit path in the reaction volume; c) at least one reagent ion source and/or at least one reagent ion inlet for providing reagent ions into the reaction volume; d) optionally, at least one ion guide comprising an electrode arrangement which is configured for producing an alternating electrical, magnetic and/or electromagnetic field, that allows for guiding the reagent ions and/or the analyte ions at least along a section of the predefined transit path, preferably along the whole transit path, through the reaction volume.
    Type: Grant
    Filed: October 19, 2018
    Date of Patent: February 20, 2024
    Assignee: TOFWERK AG
    Inventors: Felipe Lopez-Hilfiker, Manuel Hutterli, Marc Gonin, Carsten Stoermer, Michael Kamrath
  • Patent number: 11904321
    Abstract: A container includes a lower portion and a lid to connect with the lower portion. The lid includes a fluidic interface, a swing bar, and a counter structure disposed on an opposite side of the fluidic interface relative to the swing bar. The fluidic interface includes a first liquid port, a second liquid port, a gas port, and a seal ring disposed around the first liquid port, the second liquid port, and the gas port, the first liquid port disposed along a center axis of the container.
    Type: Grant
    Filed: May 28, 2020
    Date of Patent: February 20, 2024
    Assignee: LIFE TECHNOLOGIES CORPORATION
    Inventors: Mark Reed, Rui Zheng
  • Patent number: 11906406
    Abstract: Provided is an automatic analysis technique that prevents liquid contained in a reaction container from locally contacting with liquid added afterward and has less occurrence frequency of equipment malfunction and high performance.
    Type: Grant
    Filed: April 5, 2018
    Date of Patent: February 20, 2024
    Assignees: Hitachi High-Tech Corporation, Roche Diagnostics Operations, Inc.
    Inventors: Daisuke Ebihara, Shinya Matsuoka, Taku Sakazume, Yuzuru Shimazaki
  • Patent number: 11892205
    Abstract: A heat pump that includes a thermoelectric device(s) and a heat sink having a raised portion with a top surface for thermally coupling with a planar face of the thermoelectric device(s). The raised portion of the heat sink includes an outer periphery and a raised central region surrounded by a void region to provide more uniform thermal conductivity when clamped within an assembly. The raised central region is shaped in an any shape corresponding to a shape of uneven thermal conductivity due to clamping pressure applied to the heat sink. The void region can be substantially contiguous and entirely circumscribe the central raised region. The device can optionally include discrete supports formed of a less thermally-conductive material within the void region. The supports can be elastomeric, such as O-rings, and disposed within pockets defined within the void region.
    Type: Grant
    Filed: November 18, 2022
    Date of Patent: February 6, 2024
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: Amir Sadri, Nenad Kircanski, Thanh-Vi Tran, Carl Marlowe, Brian David Wilson
  • Patent number: 11894110
    Abstract: To facilitate management of the entirety of one or a plurality of clinical laboratories. This information processing apparatus is used in management of a clinical laboratory in which an analyzer configured to analyze specimens is installed. The information processing apparatus includes: a communication section configured to communicate with a terminal operable by a user; and a controller configured to control display of the terminal via the communication section. On the basis of information collected from a plurality of analyzers installed in one or a plurality of clinical laboratories and from apparatuses relevant to the analyzers, the controller causes the terminal to display a screen including an index that indicates a status of the entirety of the one or the plurality of clinical laboratories. In response to the user selecting the index displayed in the screen, the controller causes the terminal to display the selected index so as to be divided in a plurality of categories.
    Type: Grant
    Filed: March 30, 2020
    Date of Patent: February 6, 2024
    Assignee: Sysmex Corporation
    Inventors: Akio Miyauchi, Naoki Tsuro, Norio Kowata, Naoki Kai, Shirou Kuwaoka, Yukihisa Minematsu, Mark Dahlberg, Steve Postma, Chris Carrier, Jackie Guenther, Anselm Mueller
  • Patent number: 11879901
    Abstract: This invention relates to an apparatus for conducting immunoassay test. The apparatus includes a groove unit having a groove along a vertical direction configured to hold a rod-shaped portion of a probe along the vertical direction, and a push pin configured to move along a horizontal direction, the push pin being capable of residing at a first position and a second position. A tip of the push pin is capable of pressing the rod-shaped portion of the probe against the groove when the push pin resides at the first position. The distance between the tip of the push pin and the groove is larger than a diameter of the rod-shaped portion of the probe when the push pin resides at the second position.
    Type: Grant
    Filed: February 8, 2023
    Date of Patent: January 23, 2024
    Assignee: ACCESS MEDICAL SYSTEMS, LTD.
    Inventors: Hong Tan, Ming Xia, Yushan Tan, Jun Chen, Erhua Cao, Genqian Li, Robert F. Zuk
  • Patent number: 11828683
    Abstract: A method of quantitating free (unbound) human C5a complement protein (C5a) from a sample comprising: binding biotinylated anti-C5a capture antibody to strepavidin-coated particles; capturing the free (unbound) C5 in the sample; detecting the captured free C5a; and quantitating the captured free C5 using laser-induced fluorescence detection; wherein the method is performed in a Gyros Bioaffy 200 CD in a Gyrolab xPlore or a Gyrolab XP instrument; wherein human C5 is first removed from the sample.
    Type: Grant
    Filed: October 19, 2017
    Date of Patent: November 28, 2023
    Assignee: Alexion Pharmaceuticals, Inc.
    Inventors: Mark Dysinger, Mark Ma
  • Patent number: 11821878
    Abstract: An autosampler includes an injection port for supplying a sample to an analysis device, a needle that collects the sample stored in a vial and injects the sample into the injection port, a cleaning unit that cleans the needle and a gas exhaust fan. The cleaning unit includes a cleaning container which stores a cleaning liquid and into which the needle is inserted, and a unit main body that has a space for storing the cleaning container and receiving the cleaning liquid overflowing from the cleaning container, and a unit gas exhaust passage for exhausting gas in the space outwardly of the cleaning unit. The unit main body has a unit opening through which the needle passes when accessing the cleaning container.
    Type: Grant
    Filed: October 23, 2018
    Date of Patent: November 21, 2023
    Assignee: SHIMADZU CORPORATION
    Inventors: Shotaro Ando, Takashi Inoue
  • Patent number: 11815438
    Abstract: A fluid sampler system includes a fluidic head including a gas aperture capable of communication with a pressurized gas source, a liquid conduit capable of communication with a sample reservoir, and a seal capable of forming a compression seal to the sample reservoir when gas pressure is applied to the sample reservoir through the gas aperture and capable of displacing a portion of the sample through the liquid conduit; and a positioning apparatus capable of positioning the fluidic head and the sample reservoir in communication with one another. A method for providing an aliquot of sample, includes forming a releasable compression seal to a reservoir including a liquid sample; pressurizing the reservoir with compressed gas; displacing an aliquot of the sample from the reservoir; and transferring the displaced aliquot of the sample to a location.
    Type: Grant
    Filed: November 5, 2021
    Date of Patent: November 14, 2023
    Assignee: CorSolutions LLC
    Inventors: Thomas N. Corso, Colleen K. Van Pelt
  • Patent number: 11808778
    Abstract: Apparatus configured to control chamber pressure during pipette rinsing having lower pressure recovery time. Pressure control apparatus includes pipettes to dispense liquid, a manifold chamber to supply liquid to the pipettes, a flow control valve in each flow path, a pump to supply the liquid, a pressure sensor to provide measured pressure, and a flow controller, which in a calibration mode, decreases a pump drive setting if measured pressure is high, increases the setting if measured pressure is low, and stores the pump drive setting for the individual combined operational state if the pressure is within predetermined pressure threshold limits, or in a testing mode, determines if the measured pressure is within the threshold limits for a previously-commanded state combination, and adjusts the pump drive setting if not within the threshold limits for a next time. Methods for operating pressure control apparatus are described, as are other aspects.
    Type: Grant
    Filed: March 28, 2019
    Date of Patent: November 7, 2023
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Richard Derman, David Haruch
  • Patent number: 11769396
    Abstract: Devices, systems, and methods for self-testing event devices of a building alarm system are described herein. One mobile device includes a user interface, a memory, and a processor configured to execute executable instructions stored in the memory to: generate, a list of event devices of an alarm system that are available for testing, providing a device selection tool that allows a user to select a number of event devices from the list of event devices, and providing a self-test initiation tool that generates an initiation message that is to be sent to the selected number of event devices.
    Type: Grant
    Filed: February 5, 2021
    Date of Patent: September 26, 2023
    Assignee: Honeywell International Inc.
    Inventors: Benjamin H. Wolf, Hariprasad Kozhikkotakathitta Veetil, Michael Barson, Christopher Dearden
  • Patent number: 11760571
    Abstract: An automated laboratory system includes a storage system including a frame and a platform slidably mounted to the frame such that the platform is slidable relative to the frame between a docked position and an undocked position, the platform being configured to carry an instrument. The system also includes a robotic device proximate the storage system and being configured to access the instrument carried by the platform. Another automated laboratory system includes a storage system including a table and a tabletop having a central axis and being rotatably positioned on the table such that the tabletop is rotatable about the central axis between a docked position and an undocked position, the tabletop being configured to carry an instrument. The system also includes a robotic device proximate the storage system and being configured to access the instrument carried by the tabletop.
    Type: Grant
    Filed: July 26, 2019
    Date of Patent: September 19, 2023
    Assignee: THERMO CRS LTD.
    Inventors: Michael Paul Riff, Jonathan Wittchen, Gary Darnel, Stephen Wayne Johnson
  • Patent number: 11747262
    Abstract: The present disclosure relates to a flow cell carrier. The flow cell carrier may include a flow cell and a frame. The frame may include a pocket and a handle. The pocket may have at least one spring feature and at least one banking feature. The frame may be configured to retain the flow cell within the pocket such that a maximal surface area of the flow cell is exposed to an optical lens. Related methods and kits are also disclosed.
    Type: Grant
    Filed: November 25, 2020
    Date of Patent: September 5, 2023
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Sandor Kovacs, Anson Hsu, David Baranson, John Van Doorn, Eli N. Glezer
  • Patent number: 11747299
    Abstract: In an embodiment, a device includes: an electrode configured to change a contact angle of a liquid droplet above the electrode when a first voltage is applied to the electrode; a sensing film overlaying the electrode, wherein the electrode is configured for assessment of a state of the liquid droplet based on a second voltage sensed at the electrode; a reference electrode above the electrode, the reference electrode configured to provide a reference voltage; and a microfluidic channel between the electrode and the reference electrode, wherein the microfluidic channel is configured to manipulate the liquid droplet using the electrode.
    Type: Grant
    Filed: May 27, 2022
    Date of Patent: September 5, 2023
    Assignee: Taiwan Semiconductor Manufacturing Co., Ltd.
    Inventors: Tsung-Tsun Chen, Allen Timothy Chang, Jui-Cheng Huang
  • Patent number: 11703504
    Abstract: An electrochemiluminescence method of detecting an analyte in a liquid sample and a corresponding analysis system. An analyte in a liquid sample is detected by first providing a receptacle containing a fluid comprising protein coated magnetic microparticles to a stirring unit. Stirring of the fluid is necessary since the density of the microparticles is usually higher than the density of the buffer fluid. Thus the microparticles tend to deposit on the bottom of the receptacle leading to an aggregation of the microparticles because of weak interactions. To obtain representative measurements a homogeneous distribution of the microparticles in the buffer fluid is necessary to ensure a constant concentration of microparticles for each analysis cycle. It is further necessary to provide disaggregation of the microparticles, which is also realized by stirring the fluid. Stirring is conducted with a rotational frequency that is adapted to the amount of fluid to be stirred.
    Type: Grant
    Filed: September 5, 2019
    Date of Patent: July 18, 2023
    Assignees: ROCHE DIAGNOSTICS OPERATIONS, INC., HITACHI HIGH-TECH CORPORATION
    Inventors: Ralf Kraus, Oliver Larbolette, Friedrich Staebler, Yoshihiro Yamashita, Yukinori Sakashita, Shinya Matsuoka, Michihiro Saito, Taku Sakazume, Katsuaki Takahashi
  • Patent number: 11697113
    Abstract: A pipette with an adjustable dosing increment, wherein a control apparatus determines a dosing volume by a set dosing increment when a syringe is inserted in the pipette, and determines a maximum possible number of dosing steps following an execution of a reverse stroke without refilling the syringe given the set dosing increment and completely or partially filled syringe by the position of a displacement means on the path, and displays the maximum number of dosing steps on a display apparatus until the reverse stroke is executed. The control apparatus also determines the number of executed dosing steps and displays the number of executed dosing steps and/or the number of dosing steps still possible without refilling the syringe on the display apparatus.
    Type: Grant
    Filed: July 21, 2020
    Date of Patent: July 11, 2023
    Assignee: Eppendorf AG
    Inventor: Burkhardt Reichmuth
  • Patent number: 11698379
    Abstract: It is an object to provide a cover slip sticking device capable of improving matching between types of clearing agents and cover slips. As a means for solving the problem, a cover slip sticking device includes a dipping bath (21) in which slide glasses (22) on which specimens are attached are housed to be dipped in a clearing agent, a holder (11) having a cover slip (10) and cover slip information (14), a mounting part (C) on which the holder is mounted, a sticking part (B) sticking the cover slip (10) taken out from the holder (11) on the slide glass (22), a reading unit (62) reading the cover slip information (14), a storage unit (65) storing a type of the clearing agent and matching information between types of clearing agents and types of cover slips and a determination unit (66) comparing the cover slip information (14) read by the reading unit (62) and the type of the clearing agent stored in the storage unit (65) with the matching information to determine whether the types match with each other or not.
    Type: Grant
    Filed: May 30, 2017
    Date of Patent: July 11, 2023
    Assignees: SAKURA SEIKI CO., LTD., SAKURA FINETEK JAPAN CO., LTD.
    Inventors: Tomonori Kawai, Yamato Miyairi
  • Patent number: 11668629
    Abstract: A microscope slide staining system has a chamber, a plurality of slide support elements, a plurality of spreading devices positionable in association with microscope slides supported on the slide support elements so the spreading devices define a gap between the spreading device and the microscope slide and so the spreading device and the microscope slide are movable relative to one another to spread at least one reagent on the microscope slide independent of the other spreading devices and microscope slides.
    Type: Grant
    Filed: September 3, 2020
    Date of Patent: June 6, 2023
    Inventor: Lee H. Angros
  • Patent number: 11638917
    Abstract: Magnetic beads having cell components of interest are translated between a sequence of processing wells in a tray without need for pipetting. The circular tray contains one or more sequences of wells each interconnected by a respective channel. The tray is rotated about a central axis and a magnet, an agitator, and a heater provided external to the tray enable magnetic bead translation, mixing, and incubation, respectively. The magnet proximate a well forms a cluster of beads. Manipulation of the tray in rotation and elevation results in translation of the cluster from one well, through a channel, and into an adjacent well. The well containing a cluster may be rotationally positioned in front of the agitator, the agitator extended into contact with the well, followed by mechanical agitation. The heater, disposed beneath the tray, may accept a well lowered thereto for selective heating.
    Type: Grant
    Filed: August 8, 2022
    Date of Patent: May 2, 2023
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Jason Bryant, Eric Yeaton, Dan Harris, Josiah Hackendorf, Steven Allen, Mark Talmer
  • Patent number: 11635442
    Abstract: A sample testing system comprising: a transporting apparatus; a testing apparatus for obtain a sample and performing testing on the obtained sample; and a controller. The controller executes operation of: controlling the transporting apparatus so as to transport the sample rack in first direction, such that each sample container held in a sample rack is transported to a obtaining position on which the testing apparatus obtains a sample and then the sample rack is transported toward the second position; changing, when retesting of a sample contained in a sample container is necessary, the transporting direction from the first direction to second direction, and then controlling the transporting apparatus so as to transport the sample container accommodating the sample, for which retesting is necessary, to the obtaining position again. Sample testing method and a computer program product are also disclosed.
    Type: Grant
    Filed: December 30, 2014
    Date of Patent: April 25, 2023
    Assignee: SYSMEX CORPORATION
    Inventors: Yuichi Hamada, Daigo Fukuma
  • Patent number: 11607690
    Abstract: An applicator or applicator system used for handling samples in an analytical laboratory setting. In particular, the invention the applicator or applicator system is capable of capping an analytical sample tube by applying a capping material to an opening of an analytical sample vessel, the applicator or applicator system including g a dispenser configured to dispense a substantially continuous length of a capping material, such that a region of the substantially continuous length of capping material is located on or about an opening of an analytical sample vessel held in a predetermined orientation.
    Type: Grant
    Filed: August 29, 2018
    Date of Patent: March 21, 2023
    Assignee: AIM LAB AUTOMATION TECHNOLOGIES PTY LTD
    Inventors: Damien Braun, Francis Harvey, David Muir-McCarey, Robert Fisher, Sandy Sherry, Zisui Yao, Rainer Novy, Matthew Grant, Peter Dalman, Thomas Knight
  • Patent number: 11607685
    Abstract: The present specification discloses a microfluidic analysis chip capable of adjusting movement of a specimen or a reagent by a negative pressure generation unit. A microfluidic analysis chip according to the present specification may comprise: a microtube for a main channel, which provides a space in which a specimen input through a specimen inlet formed at one end thereof reacts with a regent while the specimen moves to the other end thereof; a chip housing surrounding the microtube for the main channel; and a negative pressure generation unit which is positioned in the chip housing and connected to the microtube, so as to affect an internal pressure of the microtube for the main channel.
    Type: Grant
    Filed: December 22, 2017
    Date of Patent: March 21, 2023
    Assignee: BBB Inc.
    Inventors: Jaekyu Choi, Hyundoo Hwang, Dongsik Han
  • Patent number: 11592369
    Abstract: A tissue processing station includes a housing and a first heated plate that is either disposed on or forms a first horizontally oriented surface of the housing. The first heated plate is configured to either (i) contain water, or (ii) receive a dish containing water. The tissue processing station may also include a vertically-oriented heated well for heating slides. A second heated plate is either disposed on or forms an angled surface of the housing for supporting one or more laboratory slides. The angled surface is angled relative to the first horizontally oriented surface. A third heated plate is either disposed on or forms a second horizontally oriented surface of the housing for supporting one or more laboratory slides. The first and second horizontally oriented surfaces are defined at different elevations on the housing. The angled surface extends between the two horizontally oriented surfaces.
    Type: Grant
    Filed: May 10, 2021
    Date of Patent: February 28, 2023
    Assignee: Rushabh Instruments, LLC
    Inventors: Preyas Shah, Sahil Shah, Joseph Lessard, Alyicia Marie Rios, Joshua T. Greenlee, Olivia Grabowski
  • Patent number: 11573244
    Abstract: Various embodiments include a system having a pipetting chamber, a set of pipettor cartridges docked in the pipetting chamber, a gantry system mounted on a ceiling within the pipetting chamber, the gantry system including at least one stationary track aligned in a first direction, and a movable track aligned in a second direction distinct from the first direction, the movable track coupled to the at least one stationary track, and a carrier configured to transport each of the set of pipettor cartridges to a pipetting location within the pipetting chamber, the carrier configured to move each pipettor cartridge in a third direction perpendicular to both the first and second directions.
    Type: Grant
    Filed: April 2, 2020
    Date of Patent: February 7, 2023
    Assignee: HighRes Biosolutions, Inc.
    Inventors: Michael Nichols, Louis J. Guarracina
  • Patent number: 11525838
    Abstract: In an automatic analyzer in which required maintenance can be executed efficiently, without omission, an operation control unit controls operations of an analysis module (ISE, AU1, AU2) including a sample vessel transport mechanism, a reagent vessel transport mechanism, a reaction vessel transport mechanism, a sample dispensing mechanism, and a reagent dispensing mechanism, and of a display unit, and analyzes a sample accommodated in a reaction vessel. The operation control unit stores a validity period for each maintenance item of the analysis module (ISE, AU1, AU2) and an execution time for each maintenance item in a memory, displays an execution time together with an identification representation of execution priority level based on the expiration dates on the display unit, rearranges the display order of the maintenance items on the basis of the execution priority level, in accordance with an operator's instruction inputted through an operation input portion.
    Type: Grant
    Filed: November 28, 2018
    Date of Patent: December 13, 2022
    Assignees: HITACHI HIGH-TECH CORPORATION, ROCHE DIAGNOSTICS OPERATIONS, INC.
    Inventors: Chikook Ha, Mohamed Abouelsoud
  • Patent number: 11512989
    Abstract: In accordance with presently disclosed embodiments, systems and methods for determining the amount of bulk material being choke-fed into an inlet of a blender from one or more bulk material containers placed on a support structure are disclosed. The system includes sensors placed on the support structure beneath the one or more containers for determining the amount of bulk material contained within the container at any given time. By monitoring the change in the mass of the material in the containers overtime the amount of material being fed into the blender can be determined. The material is metered into a mixer within the blender using a metering mechanism, such as a sand screw, which supplies a fixed capacity of bulk material into the blender. The ability to precisely measure the amount of bulk material being choke-fed into the blender enables operators to calibrate the sand screw continuously.
    Type: Grant
    Filed: February 4, 2021
    Date of Patent: November 29, 2022
    Assignee: Halliburton Energy Services, Inc.
    Inventors: Wesley John Warren, Bryan John Lewis, Tim H. Hunter
  • Patent number: 11467173
    Abstract: The sample container loading or storing unit includes a sample rack tray and a sample rack tray installation portion on which the sample rack tray is installed, the sample rack tray installation portion includes a claw portion that moves in a contact direction with a sidewall portion of the sample rack tray, the sample rack tray includes a claw guard portion provided on the sidewall portion of the sample rack tray, and the claw guard portion is configured to be separated from the sidewall portion of the sample rack tray by being pushed by a sample rack.
    Type: Grant
    Filed: May 31, 2018
    Date of Patent: October 11, 2022
    Assignee: HITACHI HIGH-TECH CORPORATION
    Inventors: Masashi Endo, Katsuhiro Kambara, Shigeru Yano
  • Patent number: 11446618
    Abstract: A system for on-site production of chlorine dioxide and other sanitizing solutions is disclosed which includes a controller for measuring fluids into a measuring/mixing vessel. The measuring/mixing vessel is designed to measure and mix water with activator and base additives to create a ready-to-use cleaning solution. A drainage system is employed to transfer the ready-to-use cleaning solution into a reservoir for on-site use.
    Type: Grant
    Filed: October 2, 2019
    Date of Patent: September 20, 2022
    Inventors: Robertus T. Krijnen, Michael C. Pawlak
  • Patent number: 11422073
    Abstract: Various examples of systems and methods are provided for slide processing. In one example, among others, a system for processing microscope slides includes a slide positioner that can adjust a position of a slide and a slide treatment system that can dispense a micro stream of a fluid at a location on the slide when the slide is positioned beneath a jet nozzle of the slide treatment system. The system can include a slide sled that can align a smearing slide with a surface of the slide including a fluid sample is disposed, and support the smearing slide at a predefined angle with respect to the surface of the slide. In another example, a method includes obtaining a slide including a sample disposed on a surface, positioning the slide below to a jet nozzle, and dispensing a micro stream of a fluid onto the sample using the jet nozzle.
    Type: Grant
    Filed: January 4, 2019
    Date of Patent: August 23, 2022
    Inventor: William Eugene Campbell
  • Patent number: 11406981
    Abstract: Automated test instruments electronically determine and/or obtain cell availability of cells of a holding structure in an incubated test chamber and for each of a plurality of open and available cells and electronically identify neighboring cells, electronically determining whether each of the identified neighboring cells are occupied or empty and, if occupied, electronically evaluating at least one of a test status or a time from load of a specimen container held therein. The instruments then electronically rank each of the plurality of open and available cells based at least in part on whether the identified neighboring cells are occupied or empty and the at least one of test status or time from load of the occupied cells of the identified neighboring cells. The loading mechanism is then directed to load an incoming specimen container into a selected one of the open and available cells based on the ranking.
    Type: Grant
    Filed: August 21, 2019
    Date of Patent: August 9, 2022
    Assignee: BIOMERIEUX, INC.
    Inventors: Michael Edmiston, Jonathan Elenkiwich, Warren Vincent
  • Patent number: 11391654
    Abstract: Disclosed is a device for contactlessly mixing fluid present on the upper surface of the slide, where the device comprises a first nozzle array and a second nozzle array, the first nozzle array adapted to impart a bulk fluid flow to the fluid present on the upper surface of the slide, and the second nozzle array adapted to impart at least a first regional fluid flow to at least a portion of the fluid present on the upper surface of the slide.
    Type: Grant
    Filed: May 19, 2020
    Date of Patent: July 19, 2022
    Assignee: Ventana Medical Systems, Inc.
    Inventor: Nathaniel Crum
  • Patent number: 11360111
    Abstract: Provided is a connection module with a high degree of freedom for an automatic analyzer which does not depend on a device as a discharge destination. For this purpose, a module to be connected to an automatic analyzer with a rack rotor mechanism includes: a rack discharge mechanism for moving a rack from the rack rotor mechanism to a rotation holder; a rack rotating mechanism for rotating the rack moved to the rotation holder; a conveyor mechanism for transporting the rack from the rack rotating mechanism to a discharge port; and a feeder mechanism for pushing the rack out of the rotation holder to the conveyor mechanism, in which the rack rotating mechanism rotates the rotation holder from a direction parallel to the rack discharge mechanism to a direction parallel to the feeder mechanism and the conveyor mechanism in the selected rotation direction.
    Type: Grant
    Filed: August 23, 2018
    Date of Patent: June 14, 2022
    Assignee: HITACHI HIGH-TECH CORPORATION
    Inventors: Yudai Fukushi, Takamichi Mori
  • Patent number: 11360107
    Abstract: Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.
    Type: Grant
    Filed: February 25, 2015
    Date of Patent: June 14, 2022
    Assignee: Labrador Diagnostics LLC
    Inventors: Daniel Young, Samartha Anekal, Elizabeth A. Holmes, Timothy Smith, Chinmay Pangarkar, James R. Wasson
  • Patent number: 11360108
    Abstract: It is necessary to dispose a plurality of units which have different target temperatures on an apparatus in a more integrated state in order to improve analysis performance and processing capacity per unit space of the apparatus. Therefore, it is necessary to mitigate influence of temperature exerted between units. It is possible to reduce the temperature influence exerted between the units and thus efficiently control temperature by properly disposing the units in the apparatus, based on the relationship between a use environment temperature of the apparatus and a target temperature of each unit and temperature accuracy required for the unit.
    Type: Grant
    Filed: January 18, 2018
    Date of Patent: June 14, 2022
    Assignee: HITACHI HIGH-TECH CORPORATION
    Inventors: Takenori Okusa, Yoshihiro Yamashita, Shunsuke Sasaki
  • Patent number: 11353472
    Abstract: Automated analyzer (2000) comprising a housing (2010, 3010), a robotic arm comprising an end effector (2360), the end effector (2360) comprising a body (2320) rotatably connected to an articulating arm and first (2363a) and second fingers (2363b) coupled to the body (2362) and being moveable relative to each other in a first direction, each of the fingers (2363a, b) having an engagement feature (2361) projecting inwardly from each of the first and second fingers (2363a, b) and toward the other of the first and second fingers (2363a, b). The automated analyzer (2000) further comprises a shuttle platform (2030) for receiving a shuttle (2030) carrying sample containers (03), the containers carrying sample (03) to be evaluated by the analyzer (2000) and the shuttle platform (2030) comprising a jaw assembly that engages the bottom portion of the sample containers when the jaw assembly is in the closed position.
    Type: Grant
    Filed: February 17, 2017
    Date of Patent: June 7, 2022
    Assignee: BECTON DICKINSON AND COMPANY
    Inventors: Michael T. VanSickler, Brian Austin Self, Alyssa Shedlosky, Joel Daniel Krayer
  • Patent number: 11327070
    Abstract: The present disclosure provided a blood cell analyzer, a control device and a blood analysis method thereof. In the method, a first reagent is mixed with a sample to obtain a first testing sample, and then a second reagent is mixed with the first testing sample for a further reaction to get a second testing sample for basophil classification and/or HGB measurement. A blood sample may be tested in one reaction cell through time-division multiplexing technology to obtain four groups leukocytes classification result and HGB result by single detection channel. Thus, the structure of the analyzer may be greatly simplified on the premise of guaranteeing the performance of the analyzer, the size and cost of the analyzer may reduce and a performance-price ratio of the analyzer may increase.
    Type: Grant
    Filed: February 15, 2019
    Date of Patent: May 10, 2022
    Assignee: Shenzhen Mindray Bio-Medical Electronics Co., Ltd.
    Inventors: Wenjun Tong, Yijie Yang, Huaming Xu, Xing Shi