Means Is Turntable (circular) Patents (Class 422/64)
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Patent number: 8409505Abstract: A sensor-dispensing instrument adapted to handle a sensor pack contains sensors and performs a test using one of the sensors. The instrument includes an outer housing and a mechanical mechanism for rotating the sensor pack and ejecting one of the sensors from the sensor pack and through a sensor slot on the housing. The instrument also includes a sensor actuator to engage with a sensor disposed in the sensor slot, and a sensor release that is movable to disengage the sensor actuator from the sensor disposed in the sensor slot and permit the discharge of the sensor. The sensor release activates a sensor release mechanism that has a sensor release aid arm, a mounting block, and a pivot pin. The sensor release aid arm contacts the sensor disposed in the sensor slot to assist removal of the sensor from the sensor slot.Type: GrantFiled: December 16, 2011Date of Patent: April 2, 2013Assignee: Bayer HealthCare LLCInventors: Bruce A. Flora, John P. Creaven, Russell J. Micinski
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Patent number: 8409506Abstract: An apparatus for automatic execution of different treatment operations in connection with staining of tissue specimens on microscope slides, wherein the apparatus (1) comprises a loading station (2) for microscope slides (7) with tissue specimens, a number of reagent stations (3) for staining of the tissue specimens on supplied microscope slides, a conveyor (5) for transfer of microscope slides (7) between the stations (3) in accordance with a staining program, an unloading station (10) for treated microscope slides, and a control unit (19) for controlling the treatment operations in accordance with a data program. The apparatus comprise a photo station (25) with a digital camera (26) for automatic photographing with a background light source of the finished treated tissue specimens on supplied microscope slides (7).Type: GrantFiled: October 17, 2012Date of Patent: April 2, 2013Assignee: Dako Instrumec ASInventors: Oystein Ljungmann, Torstein Ljungmann
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Patent number: 8405006Abstract: A device for heating a biological sample, the device having a heating source comprising a semiconductor chip. A sample chamber, or other medium to be heated, is positioned adjacent the heating source, wherein the sample chamber is configured to house a biological sample at a predetermined temperature. A microcontroller is electrically coupled to the semiconductor chip and a sensor positioned inside, at, or near the sample chamber. The microcontroller supplies a load current to the heating source to generate heat from the heating source, and the sensor is coupled to the microcontroller to provide feedback for controlling the heat generated by the heating source. The device may also support different heating profiles that are software and/or hardware selectable.Type: GrantFiled: September 30, 2008Date of Patent: March 26, 2013Assignee: Los Alamos National Security, LLCInventor: Torsten Albert Staab
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Patent number: 8394635Abstract: A sample processing system 101 that may be automated and methods are disclosed where sample(s) 198 are arranged on a carrier element 197 and a process operation control system 171 automatically processes the sample(s) perhaps robotically according to an desired aggregation of event dictated by an input 173. Alteration of an initial aggregated event topology may be accepted while the system is processing an initial aggregation and varied-parameter robotic control simulation functionalities 606 may be accomplished to determine an enhanced sequence for processing. Suggested operator actions may be displayed that might further enhance the scheduling of the altered aggregated event topology together with an automatic operator need prompt 608 that may inform an operator of a need for a particular action in order to accomplish the desired tasks.Type: GrantFiled: May 6, 2011Date of Patent: March 12, 2013Assignee: DAKO Denmark A/SInventors: Marc Key, Gordon Feingold, Rosanne Welcher
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Patent number: 8394344Abstract: An indicator for enabling an analytical instrument to positively detect the presence of a vial in respective vial-receiving rack position regardless of whether the vial is oriented in a manner necessary for a code reader to read a code printed on the vial. Translation of a leaf spring upon insertion of a vial into a rack position causes a flag to obscure a code provided adjacent the rack position. An instrument into which the rack is installed interprets the failure of the code reader to detect this code as positive indication that a vial is disposed within the respective rack position.Type: GrantFiled: December 22, 2010Date of Patent: March 12, 2013Assignee: Stratec Biomedical Systems AGInventors: Alexander Schutt, Martin Trump
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Patent number: 8394322Abstract: A tissue processor for processing tissue samples for histological analysis. The processor comprises two retorts, wax baths, reagent containers, a pump and valve. The vale distributes the reagent from one container to either retort. Separate reagent lines connect the wax baths to the retorts. A method of infiltrating a sample containing a reagent such as a dehydrating reagent like an alcohol, where the infiltrating material is heated to a temperature at or above the boiling point of the reagent, to boil off the reagent when the tissue sample is contacted by the infiltrating material. The pressure in the retort may be reduced to lower the boiling point of the reagent.Type: GrantFiled: April 3, 2008Date of Patent: March 12, 2013Assignee: Leica Biosystems Melbourne Pty LtdInventors: Victor Camfield Windeyer, Michael Houston Drummond, Stephen Gregory Phillip
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Patent number: 8377377Abstract: An automated microscope slide staining system and staining apparatus and method that features a plurality of individually operable miniaturized pressurizable reaction compartments or a pressurizable common chamber for individually and independently processing a plurality of microscope slides. The apparatus preferably features independently movable slide support elements each having an individually operable heating element.Type: GrantFiled: August 28, 2009Date of Patent: February 19, 2013Inventor: Lee H. Angros
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Patent number: 8372340Abstract: Cartridges for the isolation of a biological sample and downstream biological assays on the sample are provided. In one embodiment, a nucleic acid sample is isolated from a biological sample and the nucleic acid sample is amplified, for example by the polymerase chain reaction. The cartridges provided herein can also be used for the isolation of non-nucleic acid samples, for example proteins, and to perform downstream reactions on the proteins, for example, binding assays. Instruments for carrying out the downstream biological assays and for detecting the results of the assays are also provided.Type: GrantFiled: February 23, 2011Date of Patent: February 12, 2013Assignee: Luminex CorporationInventors: Dylan Hilmer Bird, Jesus Ching, Bruce A. Johnson, Keith E. Moravick, Bruce Richardson
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Publication number: 20130034466Abstract: A measuring section 2 is provided with a rotatable reaction table 200 for rapidly starting the measurement of a new sample even when an abnormal operation has stopped the measurement operations of many cuvettes. A controller 4 detects a residual cuvette remaining on the reaction table 200 when a measurement start instruction is received. When a residual cuvette is present, the controller 4 determines whether the residual cuvette will cause interference, and when the residual cuvette will not cause interference, sets the new sample on the reaction table 200, rotates the reaction table 200 and sequentially processes the cuvettes. In conjunction therewith, when a residual cuvette is moved to the end position C56, the liquid is aspirated and discarded through a discarding port W via a drain unit 282.Type: ApplicationFiled: August 2, 2012Publication date: February 7, 2013Inventors: Yuji Wakamiya, Tomoyuki Nishida
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Patent number: 8361388Abstract: Contemplated herein is an automated microscope slide antigen recovery and staining apparatus and method that features a plurality of individually operable miniaturized pressurizable reaction compartments for individually and independently processing a plurality of individual microscope slides. The apparatus preferably features independently movable slide support elements each having an individually heatable heating plate. Each slide support element preferably supports a single microscope slide. Each microscope slide can be enclosed within an individual pressurizable reaction compartment. Pressures exceeding 1 atm or below 1 atm can be created and maintained in the reaction compartment prior to, during or after heating of the slide begins.Type: GrantFiled: February 28, 2011Date of Patent: January 29, 2013Inventors: Lee Angros, Thomas Lee Byers
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Patent number: 8357537Abstract: The present invention provides a system and method for the simultaneous detection of multiple analytes in a sample. The detection system includes a housing that holds a reagent carousel rotatably coupled thereto. Further included in the housing is an incubator carousel rotatably coupled thereto. The housing also includes magnetic material that is associated with the incubation carousel for assisting in separation beads from reagent and wash solution. A robot, associated with the housing is configured to manipulate at least either the reagent carousel or the incubator carousel and transfer materials therebetween. Reaction vessels hold samples and reaction vessels handlers move the reaction vessels. Sample analysis is determined by at least one laser based detector.Type: GrantFiled: April 26, 2011Date of Patent: January 22, 2013Assignee: Bio-Rad Laboratories, Inc.Inventors: Lawrence Blecka, Larry Seamer, Sachi Rastogi, Chris Tsai, Nasser Jafari, Ken J. Lafredo
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Patent number: 8354079Abstract: The invention relates to a sealing assembly for a metering device, in particular a multi-channel metering device. The sealing assembly serves to seal pipette tips with respect to the metering device. A multi-channel metering device comprises a multiplicity of openings arranged in one plane. A sealing plate with holes in the grid of the openings abuts this plane. Each pipette tip is provided with an annular collar which has an abutting face and is pressed against the sealing plate by force closure so as to enclose one hole.Type: GrantFiled: March 19, 2012Date of Patent: January 15, 2013Assignee: CyBio AGInventor: Uwe Naumann
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Patent number: 8349564Abstract: An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations in which discrete aspects of the assay are performed on fluid samples contained in sample vessels. The analyzer includes stations for automatically preparing a sample, incubating the sample, preforming an analyte isolation procedure, ascertaining the presence of a target analyte, and analyzing the amount of a target analyte. An automated receptacle transporting system moves the sample vessels from one station to the next. A method for performing an automated diagnostic assay includes an automated process for isolating and amplifying a target analyte, and, in one embodiment, a method for real-time monitoring of the amplification process.Type: GrantFiled: November 4, 2010Date of Patent: January 8, 2013Assignee: Gen-Probe IncorporatedInventors: Jerzy A. Macioszek, Christopher B. Davis, Gary D. Lair, Thanh N. Nguyen, Haitao Li, Florence F. Li, Byron J. Knight, Robert F. Scalese, Robert E. Heinz
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Patent number: 8341886Abstract: A gate assembly is provided including frame means for positioning in an opening through which selective entry is required. Barrier means are mountable on the frame means via hinge means and the barrier means are movable relative to the frame means between a closed position, wherein the opening is closed, to an open position, wherein the opening is open. An automatic closure mechanism is provided for moving the barrier means from the open position to the closed position without user intervention. The automatic closure mechanism is associated with the hinge means and includes at least one ramp or inclined surface on which at least part of the gate travels when moving between the open and closed positions.Type: GrantFiled: July 10, 2008Date of Patent: January 1, 2013Assignee: Munchkin, Inc.Inventor: Adam Yates
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Patent number: 8343778Abstract: The invention encompasses microfluidic microarray assemblies (MMA) and subassemblies and methods for their manufacture and use. In one embodiment, first and second channel plates are provided and are sealingly connected to a test chip in consecutive steps. Each plate includes microfluidic channels configured in a predetermined reagent distribution pattern. The test chip comprises a plurality of discrete test positions, each test position being located at the intersection between a first predetermined reagent pattern and a second predetermined reagent pattern, wherein at least one of said patterns is non-linear. The first channel plate allows the distribution of a first reagent on said test chip, wherein said first reagent is immobilized at said test positions. The second channel plate allows the distribution of a second reagent on said test chip, wherein said second reagent comprises a plurality of different test samples.Type: GrantFiled: December 12, 2005Date of Patent: January 1, 2013Assignee: Simon Fraser UniversityInventors: Hua Zhong Yu, Meenakshinathan Parameswaren, Paul Chi Hang Li, Xing Yue Peng, Hong Chen, Wa Lok Chou
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Patent number: 8343423Abstract: A diluted sample is reused to remeasure a sample whose measurement has been completed, which is to be manually performed. An automatic analyzer can set hold and discard conditions and manage the elapsed time after a diluted sample is pipetted. It is possible to check, before measurement is performed, whether or not each requested measurement item can be measured, and the length of time it takes before measurement of all samples is completed. The automatic analyzer has functions of: setting diluted sample hold and discard conditions; allowing an operator to specify a kind of sample, for example, to select between a parent sample and a diluted sample; separately executing pipetting or measurement; and displaying each requested measurement item for which a sample or a reagent is insufficient, and displaying the length of time it takes until measurement of all samples is completed.Type: GrantFiled: December 17, 2008Date of Patent: January 1, 2013Assignee: Hitachi High-Technologies CorporationInventors: Hiroki Mori, Yasuo Kaneko, Toshihide Orihashi
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Patent number: 8337754Abstract: Disclosed herein are systems and methods for the developing of immuno-stained biological samples. The systems disclosed herein are automated and are configured to control one or more steps of the developing procedure. Reagents may be added using automatic syringe dispensing. Reagent temperature, reagent stirring, and wash procedures are programmable and can be separately controlled for separate immuno-staining procedures that are performed at the same time.Type: GrantFiled: December 22, 2009Date of Patent: December 25, 2012Assignee: Vertex Pharmaceuticals, IncorporatedInventors: Michael P. Emery, Matthew C. Wallace, James E. Sinclair, Raymond J. Gonzales, Brian Grot, Sanjay S. Magavi
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Patent number: 8337755Abstract: The present invention provides a protocol and apparatus for enriching circulating tumor cells and other rare cells from blood, including debris and other components, from samples with high precision and at high throughput rates. This invention discloses an improved processing system from previously described semi-automated sample processing. The system further reduces operator intervention and hands-on time from prior systems. While this system has general utility in processing diverse materials, the system is configured for sample processing of biological specimens to provide an enriched fraction suitable for detection, enumeration and identification of target cells by appropriate analytical methodologies.Type: GrantFiled: March 13, 2006Date of Patent: December 25, 2012Assignee: Veridex, LLCInventors: Teresa Bendele, Thomas Harbart, Dave Howard, Michael Kagan, Douglas Keene, Dave Lapeus, Jared Mayes, Douglas Paynter, Jerry Prohaska, Herman Rutner
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Patent number: 8337753Abstract: An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations, or modules, in which discrete aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automatically preparing a specimen sample, incubating the sample at prescribed temperatures for prescribed periods, performing an analyte isolation procedure, and ascertaining the presence of a target analyte. An automated receptacle transporting system moves the reaction receptacles from one station to the next.Type: GrantFiled: October 19, 2007Date of Patent: December 25, 2012Assignee: Gen-Probe IncorporatedInventors: Kelly G. Ammann, Robert E. Schneider, Robert J. Smith
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Publication number: 20120318302Abstract: An automated clinical analyzer and method is offered which can clean the nozzles of a reaction cuvette wash unit. A first detergent is put in first reagent containers located on a first reagent turntable. A computer controller drives a first reagent pipette to aspirate the detergent from the first reagent containers and to deliver the detergent into reaction cuvettes. The controller drives a reaction turntable to bring each reaction cuvette holding the detergent therein to the reaction cuvette wash unit. The controller drives the reaction cuvette wash unit to aspirate the detergent from inside the reaction cuvettes using reaction cuvette wash nozzles to thereby clean the wash nozzles. A second detergent is then used to clean the nozzles.Type: ApplicationFiled: June 13, 2012Publication date: December 20, 2012Applicant: JEOL LTD.Inventor: Yoshiyuki Nakayama
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Patent number: 8334145Abstract: A cap having a plurality of spaced-apart grooves in a downwardly tapered inner wall of the cap to facilitate the formation of air passageways as the cap is penetrated by a pipette tip. The air passageways aid in venting air from a fluid-holding vessel closed with the cap.Type: GrantFiled: July 21, 2008Date of Patent: December 18, 2012Assignee: Gen-Probe IncorporatedInventors: Bruce W. Anderson, Mordi I. Iheme, Kathleen A. Dickey
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Patent number: 8329103Abstract: An sample analyzer, which enables to confirm an analysis remaining time for each sample and a total analysis remaining time for all samples set in the analyzer, so that time management for both each sample and all samples can be easily performed, is disclosed. Specifically, an analyzing unit analyzes a sample by executing an analysis sequence including a predetermined number of analyzing steps, and an control device calculates an analysis remaining time for each sample based on the number of analyzing steps. Control device acquires a total analysis remaining time by calculating the analysis remaining time for the sample in which sample information is lastly inputted. The display member displays the analysis remaining time and the total analysis remaining time.Type: GrantFiled: September 18, 2008Date of Patent: December 11, 2012Assignee: Sysmex CorporationInventors: Yuji Wakamiya, Tomohiro Okuzaki, Hisato Takehara
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Patent number: 8329101Abstract: A sample analyzer includes a transporting device configured to transport a rack for holding a plurality of sample containers containing samples respectively, a barcode reader configured to read a barcode of the rack transported by the transporting device, and an aspirating device that includes an aspirating tube and a moving device configured to move the aspirating tube in a direction to insert the aspirating tube in a sample container. The sample analyzer further includes a controller configured to determine, based on the container type identifying information included in the barcode read by the barcode reader, an aspiration position for aspirating a sample in a sample container and to control insertion of the aspirating tube in the sample container at the determined aspiration position, and an analyzing part configured to analyze the sample aspirated by the aspirating device.Type: GrantFiled: March 20, 2012Date of Patent: December 11, 2012Assignee: Sysmex CorporationInventor: Kyozo Fujita
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Patent number: 8329100Abstract: An automated in situ heat induced antigen recovery and staining method and apparatus for treating a plurality of microscope slides. The process of heat induced antigen recovery and the process of staining the biological sample on the microscope slide are conducted in the same apparatus, wherein the microscope slides do not need to be physically removed from one apparatus to another. Each treatment step occurs within the same reaction compartment. The reaction conditions of each reaction compartment for treating a slide can preferably be controlled independently, including the individualized application of reagents to each slide and the individualized treatment of each slide. The reagents are preferably held in a reagent dispensing strip similar to a “blister pack”.Type: GrantFiled: August 29, 2011Date of Patent: December 11, 2012Inventor: Lee Angros
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Patent number: 8323566Abstract: A liquid sample analysis device includes a holder part 11 holding a test piece 1, an optical system 20 that optically detects a reaction state of a liquid sample and a reagent, and a support member 30 that integrally supports the holder part 11 and the optical system 20. The orientation of the test piece 1 is changed with respect to the direction of gravitational force by rotating the support member 30.Type: GrantFiled: July 28, 2009Date of Patent: December 4, 2012Assignee: Panasonic CorporationInventors: Kenji Murakami, Masahiro Aga, Hideyuki Kurokawa, Takahiko Tanida, Ryosuke Yamada
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Publication number: 20120301359Abstract: According to an embodiment of the disclosure, the analyzer includes a reagent driving disk that accommodates a reagent configured for analysis and that transports the reagent to a desired position, and a fixed disk that has a reagent stand-by position in which to make a reagent container containing the reagent, temporarily stand by, and a magnetic particles stirring position for stirring magnetic particles. A portion of the reagent stand-by position is constituted by a loading system. A reagent container moving unit moves reagent containers containing the reagent, between the reagent driving unit and the fixed disk, according to analytical request status. Providing in a part of the fixed disk the loading system constructed so that reagent containers containing the reagent can be mounted therein during operation enables changing of reagent containers, irrespective of an operational status of the reagent driving disk, and the system to having cold-storage functionality.Type: ApplicationFiled: January 27, 2012Publication date: November 29, 2012Inventors: Reinhold Kraemer, Susumu Sakairi, Stephan Sattler, Katsuaki Takahashi
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Publication number: 20120301358Abstract: A junction for transporting sample racks in an analytical system having one or more work cells for processing samples and a method thereof are disclosed. In one embodiment, the junction may include multiple main transport lines, a turntable and one or more bypass transport lines. The multiple main transport lines can transport first sample racks and second sample racks having different sizes. The rotatable transport line can alternately connect to one or more of the main transport lines. Each of the one or more bypass transport lines can interconnect two of the main transport lines and bypass the turntable. Each of the bypass transport lines can be curved such that transport of the second sample racks through each of the bypass transport lines is enabled and transport of the first sample racks through each of the bypass transport lines is disabled.Type: ApplicationFiled: November 22, 2011Publication date: November 29, 2012Applicant: ROCHE DIAGNOSTICS OPERATIONS, INC.Inventor: Joerg Haechler
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Patent number: 8318500Abstract: An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations, or modules, in which discrete aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automatically preparing a specimen sample, incubating the sample at prescribed temperatures for prescribed periods, performing an analyte isolation procedure, and ascertaining the presence of a target analyte. An automated receptacle transporting system moves the reaction receptacles from one station to the next.Type: GrantFiled: October 19, 2007Date of Patent: November 27, 2012Assignee: Gen-Probe, IncorporatedInventors: Kelly G. Ammann, Robert E. Schneider, Robert J. Smith
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Patent number: 8318095Abstract: An apparatus for automatic execution of different treatment operations in connection with staining of tissue specimens on microscope slides, wherein the apparatus (1) comprises a loading station (2) for microscope slides (7) with tissue specimens, a number of reagent stations (3) for staining of the tissue specimens on supplied microscope slides, a conveyor (5) for transfer of microscope slides (7) between the stations (3) in accordance with a staining program, an unloading station (10) for treated microscope slides, and a control unit (19) for controlling the treatment operations in accordance with a data program. The apparatus comprise a photo station (25) with a digital camera (26) for automatic photographing with a background light source of the finished treated tissue specimens on supplied microscope slides (7).Type: GrantFiled: January 31, 2007Date of Patent: November 27, 2012Assignee: Dako Instrumec ASInventors: Øystein Ljungmann, Torstein Ljungmann
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Patent number: 8313694Abstract: An automated in situ heat induced antigen recovery and staining method and apparatus for treating a plurality of microscope slides. The process of heat induced antigen recovery and the process of staining the biological sample on the microscope slide are conducted in the same apparatus, wherein the microscope slides do not need to be physically removed from one apparatus to another. Each treatment step occurs within the same reaction compartment. The reaction conditions of each reaction compartment for treating a slide can preferably be controlled independently, including the individualized application of reagents to each slide and the individualized treatment of each slide. The reagents are preferably held in a reagent dispensing strip similar to a “blister pack”.Type: GrantFiled: August 29, 2011Date of Patent: November 20, 2012Inventor: Lee Angros
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Patent number: 8313695Abstract: An automatic analyzer for performing analysis of a precision control sample in response to an external factor to alleviate the burden on the operator and perform precision control at appropriate timing, thereby allowing automatic maintenance of the measurement precision. Analysis of a precision control sample is performed by creating an analysis request for the internally held precision control sample and then transferring the precision control sample in response to an external factor occurring, when a calibrator is inputted in the analyzer, the number of remaining reagents under analysis satisfies a predetermined condition (becomes zero or falls below a specified value), the date changes, a specified time runs out, the operator is changed, the number of analyzed samples exceeds a specified value, a specified time period has elapsed, a new reagent is registered, and a measurement failure is detected.Type: GrantFiled: April 26, 2011Date of Patent: November 20, 2012Assignee: Hitachi High-Technologies CorporationInventor: Masashi Akutsu
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Patent number: 8309358Abstract: An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations, or modules, in which discrete aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automatically preparing a specimen sample, incubating the sample at prescribed temperatures for prescribed periods, performing an analyte isolation procedure, and ascertaining the presence of a target analyte. An automated receptacle transporting system moves the reaction receptacles from one station to the next.Type: GrantFiled: October 30, 2007Date of Patent: November 13, 2012Assignee: Gen-Probe IncorporatedInventors: Kelly G. Ammann, Robert E. Schneider, Robert J. Smith
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Patent number: 8309027Abstract: Provided is a specimen preparation apparatus capable of supplying a specimen from the specimen preparation apparatus to a specimen analyzer without burdening an operator. This specimen preparation apparatus comprises a stained specimen preparation part for preparing a specimen on a slide glass and staining the specimen, a keeping part for storing the stained specimen slide glass prepared in the stained specimen preparation part and a control part for deciding whether to supply the stained specimen slide glass to the keeping part or to the external apparatus.Type: GrantFiled: June 29, 2012Date of Patent: November 13, 2012Assignee: Sysmex CorporationInventors: Masanori Nakaya, Yoshihiro Hyousa, Shigeru Kitagawa, Eisuke Kobayashi, Hideyuki Higuchi
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Publication number: 20120282137Abstract: Reaction vessels and a reaction vessel detecting mechanism are disposed on the outer circumference of a reaction disk. A positional detector for detecting the position of a reaction vessel is placed on the track of the reaction vessels. A light source and a spectrophotometer are also disposed so as to sandwich one of the reaction vessels, thereby measuring the light intensity of the reaction vessels. With this arrangement, the steps of: repetitively starting and stopping the rotation of the reaction disk with high resolution; conducting photometric measurement while the reaction disk is being halted; and acquiring an absorbance distribution of the reaction vessels are performed. This makes it possible for an automatic analyzer, which examines particular constituents of a biological sample (e.g., blood and urine), to detect contaminants and scars on the reaction vessels in a separate manner, thereby ensuring the high quality of the reaction vessels.Type: ApplicationFiled: January 21, 2011Publication date: November 8, 2012Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATIONInventor: Goro Yoshida
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Patent number: 8303908Abstract: This invention relates to technology for analyzing a specific component in a sample liquid, and provides an analyzing tool and an analyzing apparatus. Analyzing tool (Y) includes a liquid inlet (61) at a central portion of the tool and a plurality of channels (51) which communicate with liquid inlet (61) and move the sample liquid introduced through liquid inlet (61) by capillary action from the central portion towards a peripheral portion of the tool. Each channel (51) extends linearly for example from the central portion towards the peripheral portion, and the plurality of channels (51) are arranged radially.Type: GrantFiled: October 24, 2003Date of Patent: November 6, 2012Assignee: ARKRAY, Inc.Inventors: Takayuki Taguchi, Shigeru Kitamura, Yuichiro Noda, Toshihiko Harada
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Patent number: 8298484Abstract: The present invention relates to an analyzer (1) which includes a placement part (11) for placing an analysis piece, and a photometric measurer (7) for photometric measurement of the analysis piece (2). In the analyzer (1), the placement part (11) holds the analysis piece (2) in such a way that a row of reagent pad (20) on the analysis piece (1) lie in right-and-left directions (D3, D4). The photometric measurer (7) is farther from a front than the placement part (11). The analysis piece (2) placed on the placement part (11) is conveyed from front toward rear (Direction D1), with the row of reagent pads (20) laid in right-and-left directions (D3, D4), toward the photometric measurer (7).Type: GrantFiled: May 10, 2005Date of Patent: October 30, 2012Assignee: ARKRAY, Inc.Inventors: Yasumitsu Takagi, Hisakazu Sugie, Toshiyuki Otsuki, Norimasa Nishida, Yoshikiyo Hongo
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Patent number: 8298497Abstract: A delivery apparatus for selectively delivering one or more liquid reagents into a reaction or test chamber (2), especially of an assay apparatus, the apparatus comprising: one or more respective storage chambers (5,6) for containing the one or more liquid reagents and arranged generally above the reaction or test chamber (2); and a plunger element (4) arranged and operable for insertion into the mouth of a selected storage chamber so as to displace a selected reagent from therewithin into the reaction or test chamber (2) generally therebelow by gravitational liquid overflow from the mouth of the chamber. The apparatus may conveniently be provided as a discrete delivery unit, with the storage chambers (5,6) prefilled with the selected reagents.Type: GrantFiled: December 14, 2009Date of Patent: October 30, 2012Assignee: The Secretary of State for DefenceInventor: David James Squirrell
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Patent number: 8298815Abstract: Systems and methods of sample processing and temperature control are disclosed. The invention may especially relate to temperature control, and may in some embodiments be methods of temperature control of an automated sample processing system and methods of automated sample processing. Specifically, the present invention provides temperature control in relation to sample processing systems and methods of processing samples, and in some embodiments provides temperature control in relation to sample carriers and processing materials such as reagents. Corresponding systems and devices are disclosed, including sample processing systems (1), sample carrier temperature regulation systems (60), reagent temperature regulation systems, sample processing control systems, and temperature regulation devices, among other embodiments.Type: GrantFiled: December 22, 2003Date of Patent: October 30, 2012Assignee: DAKO Denmark A/SInventors: Kristopher Buchanan, Marc Key, John Favuzzi, Rosanne Welcher, Benno Guggenheimer, Robert Clark, Michael Barber, Bob Lathrop
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Patent number: 8288168Abstract: Improved systems and methods for tissue processing are described here. The chemical process and the construction of the apparatus are simplified by using only two different solutions in two separate reaction modules. They are compatible with processing of tissue specimens for genetic analysis, histology, in situ antibody binding and hybridization, archival preservation of morphology and nucleic acids, and combinations thereof.Type: GrantFiled: November 20, 2008Date of Patent: October 16, 2012Assignee: The University of MiamiInventor: Azorides R. Morales
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Patent number: 8287807Abstract: An analyzer for analyzing a specimen includes a central control unit that instructs systems of the analyzer of a process operation; and a primary control unit that time-divisionally outputs an instruction by the central control unit. The analyzer also includes a plurality of secondary control units; a communication connection unit; and a plurality of connecting units. The secondary control units are connected to the systems, respectively, and control an operation of the systems according to the instruction by the central control unit. Each of the secondary control units has positional information set in advance. The communication connection unit connects the primary control unit and the secondary control units. The connecting units are provided on a fixed arrangement position, have arrangement positional information indicating the arrangement position, and are connected to the secondary control units, respectively.Type: GrantFiled: December 1, 2008Date of Patent: October 16, 2012Assignee: Beckman Coulter, Inc.Inventor: Atsushi Matsushita
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Publication number: 20120258012Abstract: An automatic analyzer according to the present invention is compact, mounting great number of reagents, having high processing ability. Reagent disks are arranged at inside and outside of a reaction disk. A reagent probe can inject a reagent into the position which is common position of both reagent disks. One of plural reagent probes approaches to one of reagent disks at one cycle. Plural reagent probes alternatively approach to the reagent disk. Therefore, the first reagents and the second reagents can be placed on both reagent disks. The mounting number of reagents can be increased without enlarging an analyzer. The cycle time can be shortened to make an automatic analyzer to have high processing ability.Type: ApplicationFiled: June 21, 2012Publication date: October 11, 2012Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATIONInventors: Isao Yamazaki, Ryuji Tao, Katsuaki Takahashi
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Patent number: 8283175Abstract: A test device for determining the concentration of at least one analyte in a sample using a element is proposed. The test device can be used particularly for glucose measurement, in particular blood glucose measurement, cholesterol measurement and/or coagulation measurement. The test device according to the invention comprises a housing with a closed state and an opened state, and a storage device for receiving at least one test element. The at least one test element is typically designed as a strip-shaped test element, and the storage device typically comprises a magazine. The magazine comprises a plurality of cavities, and the test elements are received substantially parallel to one another in the cavities. A measuring device and a dispensing device are also provided. The dispensing device comprises means for conveying the at least one test element from at least one storage position of the storage device during opening of the housing.Type: GrantFiled: December 21, 2007Date of Patent: October 9, 2012Assignee: Roche Diagnostics Operations, Inc.Inventors: Gregor Bainczyk, Thomas Eisele, Herbert Wieder
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Patent number: 8282896Abstract: Carriers or holders for holding microfluidic devices are provided. Some of the carriers that are provided include a hydration control device and/or a source of controlled fluid pressure to facilitate use of the carrier in conducting various types of analyses.Type: GrantFiled: October 5, 2009Date of Patent: October 9, 2012Assignee: Fluidigm CorporationInventors: Geoffrey Richard Facer, Hany Ramaz Nassef
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Patent number: 8277752Abstract: An optical measurement apparatus is provided for conducting a test by efficiently reading color development of a reagent after reaction by optical measurement. To the above end, an optical measurement apparatus is provided which is to be used with at least one test instrument mounted to the apparatus. The test instrument includes a carrier provided with at least one reagent retaining portion which retains a reagent, and a sample is applied to the carrier. The optical measurement apparatus includes a reader for reading color development of the reagent retaining portion, and a controller for performing driving control of the reader and determination. The controller performs the determination by utilizing data obtained by a reading operation P to read the color development of the reagent performed after the lapse of a reaction completion period Tr1-Tr6 from the mounting of the test instrument, and the reaction completion period depends on the reagent.Type: GrantFiled: November 20, 2008Date of Patent: October 2, 2012Assignee: ARKRAY, Inc.Inventors: Takashi Nakagawa, Shinya Nakajima, Tokuo Kasai, Kazuhiro Ohmiya
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Patent number: 8277730Abstract: A tissue infiltration apparatus (1) for specimens present in cassettes (5) comprises at least two liquid containers (7, 11, 13, 15) and a transport apparatus (6). Multiple cassettes (5) are receivable in a transport basket (4). The transport apparatus (6) is configured in such a way that at least two transport baskets (4) are transportable in the tissue infiltration apparatus (1). A transport basket (4) is deliverable to, and/or movable away from, a liquid container (7, 11, 13, 15) with the transport apparatus (6). An execution sequence (21) in which the transport baskets (4) pass through the liquid containers (7, 11, 13, 15) is definable. To enable accelerated or preferred processing of a transport basket (4) with the tissue infiltration apparatus (1), at least one means (8) is provided with which the order of two transport baskets (4) is definably modifiable.Type: GrantFiled: October 12, 2011Date of Patent: October 2, 2012Assignee: Leica Biosystems Nussloch GmbHInventors: Hermann Ulbrich, Karl-Heinz Westerhoff, Stefan Künkel, Janet Minshew
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Patent number: 8277729Abstract: The present invention is to present a sample analyzer which is capable of respond immediately when a need to perform analysis of multiple items arises. The sample analyzer 1 includes a table 12 capable of holding a first rack 320 and a second rack 330; a reagent dispensing arm 120 which comprises a pipette part 121; a reagent dispensing driving section 120a for moving the reagent dispensing arm 120; a reagent barcode reader 350; and a control section 501 for controlling the reagent dispensing driving section 120a so as to move the pipette part 121 to a predetermined reagent aspirating position according to the identification information obtained by the reagent barcode reader 350.Type: GrantFiled: March 27, 2008Date of Patent: October 2, 2012Assignee: Sysmex CorporationInventors: Naohiko Matsuo, Hiroyuki Fujino, Takamichi Naito, Nobuhiro Kitagawa
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Publication number: 20120230873Abstract: The invention provides a small-sized automatic analyzer being compact, enabling a large number of analysis items to be carried out, and having a high processing speed. The automatic analyzer is particularly suitably applied to a medical analyzer used for qualitative/quantitative analysis of living body samples, such as urine and blood. A plurality of sample dispensing mechanism s capable of being operated independently of each other are provided to suck a sample from any one of a plurality of sample suction positions and to discharge the sucked sample to any one of a plurality of positions on a reaction disk. The automatic analyzer having a high processing capability can be thus realized without increasing the system size.Type: ApplicationFiled: May 17, 2012Publication date: September 13, 2012Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATIONInventors: Hideyuki YANAMI, Isao YAMAZAKI, Masaaki HANAWA, Hitoshi OTAKE
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Patent number: 8262991Abstract: The present invention relates generally to an apparatus for analysing fluid taken from a body, and more in particularly for analysing body fluids from mammals. The analysis apparatus is coupled to a dairy system for milking of cows, wherein it may be useful to analyse the status of the milk. The apparatus is preferably located as early as possible in the production chain in order to obtain results as close as possible to the cows. Hence the environment in which the apparatus is to be used may be harsh towards internal apparatus modules or consumables, therefore the apparatus is isolated and the internal environment is conditioned regarding humidity, temperature as well as the amount of ammonium. Furthermore the steps for analysing milk is automated inside the apparatus in order to avoid influence from the external environment.Type: GrantFiled: May 19, 2004Date of Patent: September 11, 2012Assignee: Lattec I/SInventors: Thomas Nikolai Carlsen, Peter Christiansen, Kristjan Freyr Gudmundsson, Frederik Nikolaj Svaerke Sonnenborg
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Patent number: 8257650Abstract: An automated analyzer for analyzing patient samples. The analyzer includes a plurality of cuvettes, which allow the samples to be mixed with various reagents. The analyzer includes one or more detectors, including a detector adapted to detect luminescence of the reaction mixture in the cuvettes. The analyzer allows for various diagnostic assays to be performed on a single system, and provides for high-sensitivity analysis at faster speeds.Type: GrantFiled: January 6, 2010Date of Patent: September 4, 2012Assignee: Siemens Healthcare Diagnostics Inc.Inventors: Allan Tit-Shing Chow, William Jackson Devlin, Sr., Timothy Patrick Evers, David Russell Thompson
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Patent number: 8257968Abstract: The present invention concerns an apparatus (1) for staining tissue samples, said apparatus (1) including a reagent section (2) or reagent containers (3); at least one staining section or tissue samples, a robotic head (22) or robotic element (20) that may move reagent to a predetermined tissue sample, said robotic element (20) being moveable above the reagent and the staining sections, a control element (85) that may manage a staining process, a 2-D optical sensor (86) to detect two-dimensional image data of a relevant property and that can feed the captured image data to the control element (86). By providing the robotic element (20) with a 2-D optical sensor (86), a common image processor may be provided having multiple functions. By using a 2-D optical image processing system, the control system of the apparatus may easily be adapted to read various types of data presentations, just as actual images for sections of the apparatus may be identified in order to assess the condition of the apparatus.Type: GrantFiled: December 19, 2003Date of Patent: September 4, 2012Assignee: DAKO Denmark A/SInventors: Doug Sweet, Marc Key, Gordon Feingold, Kristopher S. Buchanan, Bob Lathrop, John Favuzzi