Means Is Conveyor And Rack Patents (Class 422/65)
  • Patent number: 7670553
    Abstract: An automated chemical or biological sample analyzer includes a plurality of linear sample carrying racks that are moved to a processing station for conducting an analysis using one or more carousel devices. Under computer control, rotational movements of the carousel or carousels, linear movements of the transfer or shuttle mechanisms, and operation of a pipetting station are performed in a coordinated fashion so as to handle the processing of a large number of samples simultaneously in an optimized fashion that allows random ordering of samples for processing.
    Type: Grant
    Filed: March 24, 2005
    Date of Patent: March 2, 2010
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventor: Arthur L. Babson
  • Patent number: 7666363
    Abstract: A reagent cartridge for a assay device comprises a frame and at least one reagent container. A reagent cartridge frame comprises a plurality of sidewalls, one of the sidewalls includes at least one detent to engage with a flange on a reagent container, and another sidewall includes at least one notch to engage with a rib on the reagent container. The reagent cartridge frame permits various numbers of reagent containers to be placed in the frame at any position and in any order depending on the assay being performed. The reagent cartridge may also be used with as few as one reagent container.
    Type: Grant
    Filed: September 5, 2001
    Date of Patent: February 23, 2010
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Ronald N. Diamond, William A. Stark
  • Patent number: 7666358
    Abstract: A tissue cassette assembly includes a housing having a recess formed therein, and a compressible reservoir disposed partially or wholly inside of, or otherwise attached in fluid communication with, the housing recess, the compressible reservoir containing a tissue embedding material. The tissue cassette further includes a port disposed in the housing, the port in fluid communication with the compressible reservoir at one end and terminating in a sample cavity at another end. During operation, the compressible reservoir is compressed or squeezed to release the tissue embedding material into the sample cavity containing the biological sample.
    Type: Grant
    Filed: October 20, 2006
    Date of Patent: February 23, 2010
    Assignee: Cytyc Corporation
    Inventor: Steven A. Scampini
  • Patent number: 7666355
    Abstract: The present invention provides a bar-code driven, completely automated, microplate-based analyzer system for performing chemical, biochemical or biological assays. The analyzer is a modular, bench-top instrument that compactly integrates subsystems for sample dispensing, liquid handling, microplate transport, thermal incubation, vortexing, solid phase separation and optical reading. An internal processor is included for automating the instrument, and a user interface to facilitate communication with the operator via a touch-sensitive liquid-crystal display (LCD), and communicating with a remote network via multiple protocols. The analyzer includes firmware resident within the processing system and the user interface allows the operator to select pre-defined assay batch protocols and the user interface is configured in such as way so as to restrict an operator from programming the firmware.
    Type: Grant
    Filed: March 7, 2006
    Date of Patent: February 23, 2010
    Inventors: Tino Alavie, Keith Beckley, Andrew Hudson, Stephen W. Leonard, Robert Maaskant, Samad Talebpour, William Yang
  • Publication number: 20100041031
    Abstract: The invention described herein provides methods for the detection of soluble antigens. In particular, the methods provide for the detection of soluble proteins and chemicals. In addition, the invention provides methods of detecting a nucleic acid sequence in a sample. Also described is an emittor cell comprising an Fc receptor and an emittor molecule for the detection of a target particle in a sample wherein the target particle to be detected is bound by one or more antibodies. Also provided is an optoelectronic sensor device for detecting a target particle in a plurality of samples.
    Type: Application
    Filed: July 3, 2008
    Publication date: February 18, 2010
    Inventors: Eric D. Schwoebel, James D. Harper, Martha S. Petrovick, Frances E. Nargi, Todd H. Rider, Kristine E. Hogan, Richard H. Mathews, Joseph Lacirignola, Mark Hennessy, Trina R. Vian, Rose M. Joseph, Raymond S. Uttaro, Shaun Berry, Bernadette Johnson, Mark A. Hollis
  • Patent number: 7662630
    Abstract: An analyte of a sample is transferred to an analytical instrument by introducing a quantity of a compound of a standard material into a vessel containing an adsorbent material; introducing a quantity of the analyte of the sample into the vessel; and transferring the analyte of the sample and the compound of the standard material to the analytical instrument.
    Type: Grant
    Filed: November 23, 2005
    Date of Patent: February 16, 2010
    Assignee: PerkinElmer LAS, Inc.
    Inventors: Andrew Tipler, Frank DeLorenzo
  • Patent number: 7662339
    Abstract: An assembly suitable for use in a laboratory instrument is set forth. The assembly comprises a plurality of guide rods that are disposed generally parallel with one another and a plurality of carriage assemblies connected for movement along the plurality of guide rods. A sub-carriage assembly is disposed on at least one of the carriage assemblies and is connected to the carriage assembly for movement in a direction transverse to the plurality of guide rods. A plurality of carriage drive mechanisms are employed to move the plurality of carriage assemblies independently along said plurality of guide rods and a sub-carriage drive mechanism is provided to move the sub-carriage assembly in a direction transverse to said plurality of guide rods.
    Type: Grant
    Filed: October 22, 2004
    Date of Patent: February 16, 2010
    Assignee: Beckman Coulter, Inc.
    Inventors: Robert J. Mattila, Brian D. Wilson
  • Publication number: 20100034701
    Abstract: It is described a conveyor of specimen containers (9) supported by carriers (8) in laboratory automation systems comprising at least one analyzer (10, 50, 60). Said conveyor comprising a main transport unit (2), at least one spur transport unit (4-5, 7) allowing the positioning of the specimen container (9) inside said at least one analyzer (10, 50, 60) without removing said specimen container (9) from its carrier (8).
    Type: Application
    Filed: October 10, 2006
    Publication date: February 11, 2010
    Inventor: Gianandrea PEDRAZZINI
  • Publication number: 20100028203
    Abstract: A laboratory system for handling sample tube racks, an alignment element for sample tube racks and a rack tray receiver assembly are disclosed. The laboratory system to handle laboratory sample tube racks comprises a robotic arm (220) with a gripper (222) for gripping primary racks (PR), wherein the primary racks (PR) to be handled comprise a first end surface (76) and a second end surface (78), the first end surface (76) having a first surface geometry and the second end surface (78) having a second surface geometry, and wherein the gripper (222) comprises a first gripping arm (226) and a second gripping arm (228), with the first gripping arm (226) having a gripping surface being complementary to the first surface geometry, and the second gripping arm (228) having a gripping surface being complementary to the second surface geometry.
    Type: Application
    Filed: July 23, 2009
    Publication date: February 4, 2010
    Inventors: Rolf Frey, Fritz Goedl, Bruno Koch, Joachim Lackner, Ueli Stettler, Beat Widmer, Lydia Stettler
  • Patent number: 7648678
    Abstract: The present invention concerns a method and an apparatus for automatic staining of at least one tissue sample accommodated on a slide by applying reagents. The system may include at least one slide provided in a slide rack, a fluid containment element, a slide holder, a vertical slide positioner to pivot the slides to a vertical position, and a slide immerser element to immerse the vertical slide into a fluid containment element or even a dip tank. By pivoting the slides from a horizontal to a vertical position, an automated method and apparatus for carrying out a pretreatment in an automated staining apparatus may be provided. The pivoting of slides may ensure an appropriate orientation of the slides for both the pretreatment and the staining processes.
    Type: Grant
    Filed: December 8, 2003
    Date of Patent: January 19, 2010
    Assignee: DAKO Denmark A/S
    Inventors: John Favuzzi, Benno Guggenheimer, Jeff Rau, Marc Key, Robert Lathrop, Rosanne Welcher
  • Patent number: 7641855
    Abstract: A system for automatically testing a sample aliquot retained in temporary storage in environmentally controlled conditions on an automated clinical analyzer for a period of time without requiring operator intervention.
    Type: Grant
    Filed: August 25, 2006
    Date of Patent: January 5, 2010
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Edward Francis Farina, Russell John Butler, Samuel Garfield Ferguson, Jr.
  • Patent number: 7642093
    Abstract: An automated staining system and a reagent container designed for use with the automated staining apparatus. The reagent container includes a reagent containment section capable of containing a volume of a reagent. The reagent containment section includes an upper wall and a base wall that are spaced apart along an axis. The base wall includes a well having a nadir that is aligned axially with an access opening in the upper wall so that a reagent probe entering the opening parallel to the axis will travel toward the nadir. In another aspect of the invention, the reagent container may include a two-dimensional data element containing reagent information. The staining apparatus may include one removable drawer for holding reagent containers and another removable drawer holding slides.
    Type: Grant
    Filed: October 13, 2008
    Date of Patent: January 5, 2010
    Assignee: Lab Vision Corporation
    Inventors: Ken K. Tseung, Norman K. Rhett, Glenn K. Takayama, Wai Bun Wong, Delia P. Yuen
  • Publication number: 20090325274
    Abstract: An analyzer comprising: a first specimen holder configured to hold a plurality of first specimen containers; a conveying assembly for conveying the first specimen containers held in the first specimen holder; a second specimen holder arranged at a position higher than an upper end of the first specimen containers held in the first specimen holder; a holder moving assembly for moving the second specimen holder so as to pass the upper side of at least one of the first specimen containers held in the first specimen holder; a container transferring assembly for transferring at least one of the first specimen containers from the first specimen holder to the second specimen holder; and a controller for controlling the holder moving assembly and the container transferring assembly, is disclosed.
    Type: Application
    Filed: March 6, 2009
    Publication date: December 31, 2009
    Inventors: Yuichi Hamada, Masaharu Shibata, Daigo Fukuma
  • Patent number: 7632462
    Abstract: An assay apparatus comprising: i) an assay cartridge (52,53) comprising at least one well (57-62) and a pipette (50) positionable in at least one said well; ii) a holder arranged to receive said cartridge; iii) drive means operable to position said pipette in selected wells of said cartridge; iv) a gas pressure applicator couplable to said pipette whereby to cause liquid flow through said membrane; and v) a radiation detector operable to detect radiation from a well of said cartridge or from said pipette.
    Type: Grant
    Filed: May 9, 2002
    Date of Patent: December 15, 2009
    Assignee: Axis-Shield ASA
    Inventors: Jostein Holtlund, Stig Morten Borch, Thorstein Seim, Tore Janson, Hege Tøn, Jan Roger Karlson, Inger Lise Lauvstad
  • Patent number: 7632468
    Abstract: A retaining clip for retaining reagent test slides in a stacked arrangement includes a first assembly having a first cover plate and at least two parallel, co-planar rails extending transversely from an inner surface of the first cover plate. A second assembly includes a second cover plate, and a rail receiving platform extending transversely from an inner surface of the second cover plate. The first cover plate and the second cover plate define between them a space for receiving the plurality of reagent test slides. The rails of the first assembly include ratchet teeth, and the rail receiving platform of the second assembly includes pawls. The pawls engage the ratchet teeth to prevent the separation of the first assembly and the second assembly and to securely but removably hold the plurality of reagent test slides in a stacked arrangement between the first and second cover plates.
    Type: Grant
    Filed: December 2, 2004
    Date of Patent: December 15, 2009
    Assignees: IDEXX Laboratories, Inc., Ortho-Clinical Diagnostics, Inc.
    Inventors: Stanislaw Barski, Joseph Michael Chiapperi, Mark Elliott Deacon, Mark R. Dumont, Mark Weston Pierson, Timothy Robert Keegan, Mark Benno Loeser, Gerald George Meiler, Ross Bryan Goldman, Carl Russell Rich, Richard James Versluys
  • Patent number: 7632405
    Abstract: An apparatus and method for carrying out the affinity separation of a target substance from a liquid test medium by mixing magnetic particles having surface immobilized ligand or receptor within the test medium to promote an affinity binding reaction between the ligand and the target substance. The test medium with the magnetic particles in a suitable container is removably mounted in an apparatus that creates a magnetic field gradient in the test medium. This magnetic gradient is used to induce the magnetic particles to move, thereby effecting mixing. The mixing is achieved either by movement of a magnet relative to a stationary container or movement of the container relative to a stationary magnet. In either case, the magnetic particles experience a continuous angular position change with the magnet.
    Type: Grant
    Filed: March 15, 2005
    Date of Patent: December 15, 2009
    Inventor: Iqbal Waheed Siddiqi
  • Patent number: 7625525
    Abstract: A machine for processing samples of biological tissues or the like, comprising a box-like structure, which delimits a compartment for accommodating trays for containing sample treatment liquid (the trays being arranged in preset positions of the compartment), and racks for supporting at least one sample supporting slide to be inserted in the trays. The machine comprises elements for transfer within the compartment for the trays and the racks, both individually and with the racks inserted in the trays.
    Type: Grant
    Filed: November 14, 2005
    Date of Patent: December 1, 2009
    Assignee: Kaltek S.R.L.
    Inventor: Lorenzo Cortelazzo
  • Patent number: 7625524
    Abstract: A highly-reliable, inexpensive and small-sized automatic analyzer is provided which can eliminate the need of an additional space for piercing a seal of a reagent bottle and can prevent a deviation of a reagent sampling nozzle from the position of a pierced hole. A piercing tool for piercing the seal of the reagent bottle is fitted over a nozzle of a reagent sampling mechanism, and a stripper for automatically fitting and removing the piercing tool is provided. By fitting the piercing tool for piercing the seal of the reagent bottle over the nozzle of the reagent sampling mechanism, the seal of the reagent bottle can be pierced in situ on a reagent disk by using the piercing tool. An additional space so far required for the seal piercing is no longer needed and a deviation between the seal piercing position and the reagent sampling position is prevented.
    Type: Grant
    Filed: October 2, 2003
    Date of Patent: December 1, 2009
    Assignees: Hitachi High-Technologies Corporation, Hitachi Science Systems, Ltd.
    Inventors: Tetsuya Isobe, Katsuaki Takahashi, Isao Yamazaki
  • Patent number: 7622078
    Abstract: The apparatus comprises an assembly of modules functionally interrelated with one another, and controlled by means of a central control unit in an embodiment of circular type in concentric rings of a reagent module and a rotatory carousel carrying the incubation reaction containers, with adjacent and external arrangement of a module for feeding the disposable reaction containers by means of detachable racks and a scanning device likewise concentric with the carousel, combining with a unit for feeding by pushing the reaction containers from the racks towards the grooves of the incubation carousel, and of two displacement arm devices.
    Type: Grant
    Filed: November 8, 2005
    Date of Patent: November 24, 2009
    Assignee: Grifols, S.A.
    Inventor: Josep Pagés Pinyol
  • Patent number: 7622079
    Abstract: A fluid distribution system comprises a table configured to engage at least two microplates and moveable in an X-Y plane and in a Z direction toward and away from the X-Y plane. The fluid distribution system can comprise a dispensing head that comprises a plurality of dispensing tips adapted to dispense fluid to one or more locations of a microplate. A plate-handling device is provided to selectively pick up and deposit, substantially simultaneously, two or more of the microplates. The fluid distribution system can further comprise an accessory carriage configured to engage a source of fluid and move the source of fluid into a position adjacent the dispensing head in position for the dispensing head to aspirate fluid from the source of the fluid.
    Type: Grant
    Filed: March 22, 2005
    Date of Patent: November 24, 2009
    Assignee: Applied Biosystems, LLC
    Inventor: Dennis A. Lehto
  • Patent number: 7610941
    Abstract: In a solid phase extraction (SPE) device, once all the columns of the SPE plate are filled with liquid, the needles cooperate with engagement formations on a pusher element for pushing down the plate together with an upwardly biased shoe into sealing engagement with a peripheral spacer surrounding a container. Simultaneously, vacuum is applied by appropriate control of a valve and all the columns simultaneously transfer liquid into the drain container. Then, vacuum is released, needles engage recesses to move a carriage above a collect container and a similar prosecution is resumed.
    Type: Grant
    Filed: February 2, 2004
    Date of Patent: November 3, 2009
    Assignee: Gilson S.A.S.
    Inventor: Michel Kubacki
  • Patent number: 7608456
    Abstract: In a microplate processing apparatus that removes lid (11) of microplate (10) conveyed by microplate conveying mechanism (3), performs a dispensing process by dispensing head (8), and attaches lid (11) after the dispensing process is completed, lid (11) removed by lid removing mechanism (6) at second position (P2), is conveyed to fourth position (P4) located downstream, in advance of microplate (10) with this lid (11) having been attached, by microplate conveying mechanism (3), to be retained by lid attaching mechanism (9), and then is attached to microplate (10) having been conveyed to fourth position (P4), after the dispensing process is completed.
    Type: Grant
    Filed: April 5, 2005
    Date of Patent: October 27, 2009
    Assignee: Panasonic Corporation
    Inventors: Akira Higuchi, Eiji Watanabe
  • Patent number: 7608466
    Abstract: The invention concerns a process for producing reagent carriers having a binding capability that are suitable for determining analytes in liquids, wherein the process comprises at least one step of treating a respective reagent carrier body in particular by transferring material between a treatment device and the reagent carrier body in a preparation device and wherein this treatment step takes place on the moving reagent carrier body during its transport in the preparation device or during a movement of the treatment device relative to the reagent carrier body in the preparation device.
    Type: Grant
    Filed: June 20, 2005
    Date of Patent: October 27, 2009
    Assignee: Roche Diagnostics Operations, Inc.
    Inventor: Hans Hornauer
  • Patent number: 7603201
    Abstract: Systems and methods allowing for the automatic control and scheduling of a staining apparatus for biological samples on slides present within the apparatus. In some embodiments, the actions of a robot coupled to the staining apparatus, which performs some of the staining tasks on the individual slides in accordance with their respective protocols, may be prioritized and scheduled. In some embodiments, the scheduling may result in increasing or maximizing the throughput of slides. In some embodiments, robot scheduling ensures that the individual slides are processed substantially within the tolerances specified by their respective protocols. In some embodiments, the robot scheduler may respond to spontaneous user actions and adaptively schedule or re-schedule robot actions.
    Type: Grant
    Filed: January 23, 2006
    Date of Patent: October 13, 2009
    Assignee: Dako Denmark A/S
    Inventors: Gordon Alan Feingold, James B. Gilmartin, Mark Richard Holbrook, John A. Favuzzi, Marc E. Key
  • Patent number: 7597846
    Abstract: An apparatus for producing a tissue array, having at least one receiver block (1) and at least one donor block (2) that comprises tissue (3) to be investigated, is described. The donor block (2) comprises tissue (3) to be investigated, a first hollow needle (4) for creating a cavity in the receiver block (1), and a second hollow needle (5) for removing a sample from the tissue (3) and introducing the sample (3) into the cavity of the receiver block (1), being provided. For positioning of the first and/or the second hollow needle (4; 5) above the receiver block (1) and/or the donor block (2), a positioning array (11) having predefined markings, as well as a movably mounted lever, are provided for transferring the position of the markings onto a corresponding position on the donor block (2) and/or onto a corresponding position on the receiver block (1).
    Type: Grant
    Filed: August 31, 2006
    Date of Patent: October 6, 2009
    Assignee: Leica Biosystems Nussloch GmbH
    Inventors: Roland Walter, Rolf Metzner
  • Patent number: 7597848
    Abstract: A transport system for transporting and handling microtiter plates, for use in high throughput screening, diagnosis and/or combinatorial chemistry, comprising modules with devices for preparing specimens and/or introducing specimens, and/or for optical readout and/or for plate storage and/or devices for further processing steps or readout steps. The system includes an inter-modular transport system for transporting the microtiter plates between the different devices and at least one central transport system for asynchronous plate transfer between individual modules via input and output buffers.
    Type: Grant
    Filed: July 30, 1999
    Date of Patent: October 6, 2009
    Assignees: Carl Zeiss Jena GmbH, F. Hoffmann-LaRoche AG
    Inventors: Richard Ameling, Thilo Enderle, Christof Fattinger, Martin Gluch, Hansjoerg Tschirky
  • Patent number: 7595025
    Abstract: An apparatus for producing a tissue array is described. At least one receiver block (1), and at least one donor block (2) that comprises tissue (3) to be investigated, are provided, a first hollow needle (4) for creating a cavity in the receiver block (1), and a second hollow needle (5) for removing a sample from the tissue (3) and introducing the sample (3) into the cavity of the receiver block (1), being present. A pantograph (6) is provided for positioning the first and/or the second hollow needle (4; 5) above the receiver block (1).
    Type: Grant
    Filed: August 31, 2006
    Date of Patent: September 29, 2009
    Assignee: Leica Biosystems Nussloch GmbH
    Inventors: Roland Walter, Rolf Metzner
  • Patent number: 7595024
    Abstract: An apparatus for producing a tissue array, having at least one donor block (2) that comprises tissue (3) to be investigated, is described. A marked tissue section of the tissue (3) to be investigated is arranged on a specimen slide (22), a hollow needle (5) for removing a sample from the tissue (3) being present. A sighting device (12) is provided for positioning the hollow needle (5) above the donor block (2).
    Type: Grant
    Filed: August 31, 2006
    Date of Patent: September 29, 2009
    Assignee: Leica Biosystems Nussloch GmbH
    Inventors: Roland Walter, Rolf Metzner
  • Patent number: 7587952
    Abstract: A sample carrier having a top wall, a base, and a support wall joining the top wall and the base. The top wall includes aligned, spaced-apart openings on at least one side of the support wall which are sized to receive sample tubes. Sleeves depending from the top wall and circumscribing each opening direct sample tubes into sample tube holding areas. The sample tube holding areas each include one or more retaining walls extending upward from the base opposite the support wall. Springs extending outward from the support wall bias sample tubes against the retaining walls. A drip shield comprising a cover plate, a pair of through-holes for accessing sample tubes in the sample carrier, and a depending fin which separates sample tubes on opposite sides of the support wall protects against cross-contamination between sample tubes held by the sample carrier.
    Type: Grant
    Filed: October 10, 2007
    Date of Patent: September 15, 2009
    Assignee: Gen-Probe Incorporated
    Inventors: James D. Dale, Gerard J. Sevigny, Matthew W. Webb, Gus G. Tseo
  • Publication number: 20090227033
    Abstract: An analyzer comprising: a first measurement unit for measuring samples; a second measurement unit for measuring samples; a transportation device for transporting samples to the first measurement unit and the second measurement unit; prior sample measurement instructor for instructing to measure a predetermined sample prior to the other samples; and a transportation controller for controlling the transportation device to reserve the transportation of the other samples to the second measurement unit and to perform the other transportation operation, when the prior sample measurement instructor has instructed to measure the predetermined sample by the second measurement unit prior to the other samples, is disclosed. A sample transportation method and a computer program product are also disclosed.
    Type: Application
    Filed: March 6, 2009
    Publication date: September 10, 2009
    Inventors: Yuichi Hamada, Daigo Fukuma, Masaharu Shibata
  • Patent number: 7585463
    Abstract: The invention relates generally to the field of automated collection and deposition of fluid, semi-solid, and solid samples of biological or chemical materials. More specifically, the invention relates to the field of microarrayers, which are devices for autonomously depositing minute droplets of biological or chemical fluid samples in ordered arrays onto substrates. The invention also relates to tissue arrayers, which are devices for the collection and deposition of solid and semi-solid tissue samples in ordered arrays. Other aspects of the invention relate to fluidics robots, which are devices for the autonomous collection, dispensing and processing of biological or chemical fluid samples. The invention improves the throughput of microarrayers, tissue arrayers, and fluidics robots by providing methods and apparatuses to precisely and repeatably load supplies into the machines.
    Type: Grant
    Filed: October 25, 2004
    Date of Patent: September 8, 2009
    Assignee: Aushon BioSystems, Inc.
    Inventors: John Austin, Peter D. Honkanen
  • Patent number: 7585678
    Abstract: A method for determining a reference position for a pipetting needle which is part of an automatic analytical apparatus that includes a rotatable conveyor, conveyor driving means, an automatic pipetting unit having a needle transport device, excenter mechanism, a level detection means, and a reference member for determining a reference position.
    Type: Grant
    Filed: September 20, 2006
    Date of Patent: September 8, 2009
    Assignee: Roche Diagnostics Operations, Inc.
    Inventor: Rolf Sigrist
  • Publication number: 20090220379
    Abstract: An analyzer includes a measuring section for measuring samples; a transporting section for transporting a sample rack which holds sample container containing the sample to the measuring section; a motion controller for controlling the measuring section and the transporting section; an error detector for detecting an error of the analyzer; a display section; a display controller for displaying on the display section information representing handling of the sample rack present on the transporting section when the error detector detects the error; and a restart command receiver for receiving an instruction for measurement restart when the error occurs in the analyzer, wherein the motion controller controls the measuring section and the transporting section so as to selectively suction a sample required to be suctioned when the restart command receiver receives the instruction for measurement restart is disclosed. A measurement restarting method is also disclosed.
    Type: Application
    Filed: October 20, 2008
    Publication date: September 3, 2009
    Applicant: SYSMEX CORPORATION
    Inventors: Yuji WAKAMIYA, Hisato TAKEHARA
  • Patent number: 7584019
    Abstract: Systems and methods allowing for the automatic control and scheduling of a staining apparatus for biological samples on slides present within the apparatus. In some embodiments, the actions of a robot coupled to the staining apparatus, which performs some of the staining tasks on the individual slides in accordance with their respective protocols, may be prioritized and scheduled. In some embodiments, the scheduling may result in increasing or maximizing the throughput of slides. In some embodiments, robot scheduling ensures that the individual slides are processed substantially within the tolerances specified by their respective protocols. In some embodiments, the robot scheduler may respond to spontaneous user actions and adaptively schedule or re-schedule robot actions.
    Type: Grant
    Filed: September 16, 2005
    Date of Patent: September 1, 2009
    Assignee: Dako Denmark A/S
    Inventors: Gordon Alan Feingold, James B. Gilmartin, Mark Richard Holbrook, John A. Favuzzi, Marc E. Key
  • Patent number: 7578978
    Abstract: A carrier for holding up to N test sample devices as they are moved through a sample testing instrument. Each of the test sample devices are held in a receiving structure such as a slot in the carrier. The carrier also includes N optical interrupt positioning features, each placed in registry with one of the receiving structures (and thereby in registry with the test sample device). The instrument includes fixed optical interrupt sensors for detecting the position of the positioning feature as the carrier is moved through the instrument. In the illustrated embodiment, the position features comprise voids formed in a rib on the lower surface of the carrier. The optical interrupt sensors are positioned below the path the carrier travels over, whereby as the carrier moves past the sensor the voids, and hence position of the test sample devices, are detected.
    Type: Grant
    Filed: October 28, 2003
    Date of Patent: August 25, 2009
    Assignee: bioMérieux, Inc.
    Inventors: Michael James Justin, James Clement Bishop, Douglas L. Hopper, Mark Joseph Fanning
  • Patent number: 7579190
    Abstract: An automated system for preparing a plurality of cytological specimens from a plurality of fluid samples in vials includes an apparatus for collecting a monolayer of cells from each sample and transferring the cells to a microscope slide for fixing, staining, and inspection. The system includes a first loading station for receiving the sample vials, a second loading station for receiving consumables such as filter membranes, a slide dispenser, and an unloading area for removing completed specimen slides. To maintain one-to-one correlation between the samples and specimens produced therefrom, the system includes a subsystem for identifying each sample and permanently marking each slide with corresponding indicia prior to transferring the specimen thereto.
    Type: Grant
    Filed: April 22, 2003
    Date of Patent: August 25, 2009
    Assignee: CYTYC Corporation
    Inventors: Roy A. Ostgaard, Theodore S. Geiselman
  • Patent number: 7577498
    Abstract: A robotic beverage server that includes a robot, a beverage dispenser in fluid communication with a plurality of beverages contained within respective beverage storage receptacles and operable to dispense one or more of the beverages from the respective storage receptacles, and a controller to operate the robot to pick a container and move the container to the beverage dispenser and to operate the beverage dispenser to dispense one or more of the beverages from the storage receptacles into the container and transport the container to a user. A method of preparing a beverage or mixture of beverages that includes picking a container using a robot, moving the container to an automatic beverage dispenser, wherein the beverage dispenser is in fluid communication with and operable to dispense a plurality of beverages contained within a plurality of storage receptacles, dispensing a beverage into the container from the storage receptacles via the automatic beverage dispenser and delivering the container to a user.
    Type: Grant
    Filed: September 7, 2006
    Date of Patent: August 18, 2009
    Assignee: Motoman, Inc.
    Inventors: Craig Jennings, Mike Katchmar, Zane A. Michael, Ron Potter
  • Patent number: 7569189
    Abstract: An apparatus for opening and closing a container having a slidable shutter closure moving past the apparatus includes: a rotatable shaft having an axis perpendicular to the direction of travel of the slidable shutter, the shaft being biased against rotation in either direction; a driver for bidirectionally moving the shaft from a position away from the container to a position in the vicinity of the container for opening and closing; and an extension extending outwardly from the rotatable shaft along at least a portion of the shaft into a line of travel, whereby the extension is adapted to engage the shutter closure of the container and move the shutter closure from an open position to a closed position or from a closed position to an open position. A reagent source for an automated analyzer includes: a reagent source which includes a container having a shutter closure which slides between an open and closed position; an apparatus for opening and closing the container.
    Type: Grant
    Filed: March 30, 2005
    Date of Patent: August 4, 2009
    Assignee: Ortho-Clinical Diagnostics, Inc.
    Inventors: Merrit N. Jacobs, Robert A. Burkovich
  • Patent number: 7569190
    Abstract: A small sample cup rack adapter having a spring biased plunger moveably disposed within a generally cylindrical outer body, with the plunger adapted to support a small sample cup within the outer body. After initial contact between an aspiration probe and the bottom of the small sample cup, the probe may be lowered an additional distance, minimizing the “dead volume” of sample.
    Type: Grant
    Filed: September 5, 2006
    Date of Patent: August 4, 2009
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Tumkur R. Vijay, David R. Thompson
  • Patent number: 7560072
    Abstract: A blood analyzer that can check whether a cap is in place or not and can set a mixing mode at the same time when the specimen container is inserted. A specimen container holder holds a specimen container. A holder driving part can rotatably drive the specimen container holder around an axis arranged in a generally horizontal direction. A gradient angle detecting part detects a gradient angle of the specimen container in the specimen container holder, and a control unit controls the holder driving. The control unit receives an angle detecting signal from the gradient angle detecting part, judges whether or not a blood specimen in the specimen container is to be mixed in accordance with the gradient angle and accordingly controls the holder driving part.
    Type: Grant
    Filed: March 19, 2007
    Date of Patent: July 14, 2009
    Assignee: Horiba, Ltd.
    Inventor: Masaharu Matsumoto
  • Patent number: 7560071
    Abstract: An automated testing system includes one or more laboratory devices that operate together to perform an assay. The testing system is designed such that a laboratory device may be seamlessly integrated with the remaining devices in a quick and effortless manner. Specifically, the laboratory device is securely mounted on a slidable cart with fluid and electrical connections established therebetween. The slidable cart is in turn adapted to releasably engage with a docking station that is fixedly mounted on the workspace floor, the docking station being provided with at least one fluid input connection, an input power connection and at least one communication signal connection that are relatively permanent in nature. In order to couple the cart to the docking station, the cart is rolled generally into position above the docking station using complementary alignment posts and tracks.
    Type: Grant
    Filed: March 29, 2006
    Date of Patent: July 14, 2009
    Inventors: Michael J. Nichols, Louis J. Guarracina
  • Publication number: 20090175763
    Abstract: A device for handling of laboratory samples includes at least one gripper movable from above over a sample. The gripper includes multiple fingers arranged around an axis, an elastic finger mount, and an actuator mechanism structured and arranged to move the fingers to selectively grip or release the sample. The multiple fingers are elastically held by the elastic finger mount in a radially displaceable manner.
    Type: Application
    Filed: January 7, 2009
    Publication date: July 9, 2009
    Applicant: LICONIC AG
    Inventor: Cosmas G. MALIN
  • Patent number: 7556770
    Abstract: A transport system is provided for a sample testing machine. The transport system includes a carrier holding a set of test sample devices and a drive subsystem for moving the carrier through the sample testing machine. The drive subsystem includes a reciprocating motor-driven block engaging the carrier and moving the carrier back and forth in a predetermined longitudinal path extending along a longitudinal axis from an entrance station to a plurality of processing stations in the sample testing machine. The processing stations are accessed as the carrier is moved along the path. The carrier includes features in the form of slots that are detected by strategically placed optical interrupt sensors. As the carrier moves, the slots are detected by the sensors to thereby continuously track the position of the carrier and the test devices as they are moved through the instrument.
    Type: Grant
    Filed: March 6, 2008
    Date of Patent: July 7, 2009
    Assignee: bioMérieux, Inc.
    Inventors: Michael James Justin, James Clement Bishop, Stanley Michael Philipak, Mark Joseph Fanning
  • Publication number: 20090162247
    Abstract: Disclosed herein is a sample-processing system that can improve total system processing efficiency, and reduce a sample-processing time, by establishing a functionally independent relationship between a rack conveyance block with rack supply, conveyance, and recovery functions, and a processing block with sample preprocessing, analysis, and other functions. A buffer unit with random accessibility to multiple racks standing by for processing is combined with each of multiple processing units to form a pair, and the system is constructed to load and unload racks into and from the buffer unit through the rack conveyance block so that one unprocessed rack is loaded into the buffer unit and then upon completion of process steps up to automatic retesting, unloaded from the buffer unit. Functional dependence between any processing unit and a conveyance unit is thus eliminated.
    Type: Application
    Filed: December 23, 2008
    Publication date: June 25, 2009
    Inventors: Hitoshi TOKIEDA, Yoshimitsu TAKAGI, Takeshi Shibuya, Masashi Akutsu
  • Publication number: 20090155123
    Abstract: The technology described herein generally relates to systems for extracting polynucleotides from multiple samples, particularly from biological samples, and additionally to systems that subsequently amplify and detect the extracted polynucleotides. The technology more particularly relates to microfluidic systems that carry out PCR on multiple samples of nucleotides of interest within microfluidic channels, and detect those nucleotides. The technology still more particularly relates to automated devices for carrying out pipetting operations, particularly on samples in parallel, consistent with sample preparation and delivery of PCR-ready nucleotide extracts to a cartridge wherein PCR is run.
    Type: Application
    Filed: September 17, 2008
    Publication date: June 18, 2009
    Applicant: HANDYLAB, INC.
    Inventors: Jeff Williams, Kerry Wilson
  • Patent number: 7547414
    Abstract: For installing reagent bottles in a reagent disk, the operator needs to install them while confirming the orientation of each reagent bottle. However, the operator will groan under a psychological burden in working while confirming the orientation. If the operator installs a reagent cassette in wrong orientation, the result of measurement will be erroneous, possibly leading to a grave testing error particularly in a blood analyzer. An automatic analyzer comprises a recording medium for recording information on placement of a plurality of types of reagents contained in a single reagent container, a reagent container disk capable of carrying a plurality of the reagent containers, an information reader for reading information recorded on the recording medium, and a reagent dispense controller for controlling which of reagents is dispensed by a reagent dispenser based on the information read by medium information reader.
    Type: Grant
    Filed: July 26, 2004
    Date of Patent: June 16, 2009
    Assignees: Hitachi High-Technologies Corporation, Hitachi Science Systems, Ltd.
    Inventors: Masaharu Nishida, Hiroshi Ohga
  • Patent number: 7547417
    Abstract: A storage container for holding analytical devices, the storage container being made of a rigid material and containing separate chambers in each of which at most one analytical device can be accommodated, wherein the chambers are in a regular geometric arrangement in relation to one another and each of the chambers has at least two opposite openings each sealed by a foil, wherein at least one of the chambers comprises a means for fixing the position of an analytical device in the chamber. In addition the invention concerns a system for storing analytical devices containing a storage container according to the invention and two or more analytical devices.
    Type: Grant
    Filed: October 2, 2002
    Date of Patent: June 16, 2009
    Assignee: Roche Diagnostics GmbH
    Inventor: Klaus-Dieter Sacherer
  • Patent number: 7541001
    Abstract: An automatic pipetting and analyzing device for the preparation and analysis of samples in the wells of a microtitration plate has a work platform on which positioning areas for auxiliary devices and a movement area for the sample plate are provided, a passive mechanical table without its own drive unit, the sample plate lying within the inner passive slide of the passive mechanical table, and an active mechanical table which is arranged above the passive mechanical table and by which a pipetting head can be moved in X-Y direction over the work platform in order to extract, transport and dispense liquids by at least one pipetting channel and in order to displace the sample plate by a coupling connection with the inner passive slide, for example, to place the sample plate in an incubator or to position it with the individual wells in an analysis device.
    Type: Grant
    Filed: November 23, 2005
    Date of Patent: June 2, 2009
    Assignee: CyBio AG
    Inventors: Wolfgang Kraemer, Frank Tempel, Thomas Moore
  • Patent number: 7529598
    Abstract: A plate and method for positioning functional elements in a system for working with fluid-containing samples includes a horizontal work field having a lengthwise dimension and a perpendicularly extending transverse dimension, as well as a robot arm with a functional element, aligned essentially perpendicularly to the work field in a Z direction. The robot arm can move the functional element in at least a partial region of the work field in the X and/or Y direction. The plate includes two light barriers which intersect inside the partial region, each having a transmitter and receiver whose scanning or detection beams each extend in a direction deviating from the X direction and/or from the Y direction.
    Type: Grant
    Filed: June 16, 2004
    Date of Patent: May 5, 2009
    Assignee: Tecan Trading AG
    Inventors: Nikolaus Ingenhoven, Christian Strebel, Peter Fisch, Joas Leemann
  • Patent number: 7527764
    Abstract: An automatic system (100) for conserving samples at a controlled temperature comprising at least one controlled-temperature thermo-insulated conservation chamber (1) with temperature control means (3) containing a set of disks (9) for storing samples (19) and a Cartesian robotic system (4) equipped with pick-up device (18), contained in an upper chamber (2) separated from the chamber (1) by means of an insulating shelf (6), where said Cartesian system (4) through the controlled-access opening (7) moves the samples (19) between the I/O drawer (20) and the above-mentioned set of disks (9). The combined and synchronized movement of the robotic device (4) and of every single disk of the set enables each storage location to be reached. The management of the devices of the automatic system (100) is controlled by an N/C system driven by dedicated management SW.
    Type: Grant
    Filed: September 25, 2003
    Date of Patent: May 5, 2009
    Assignee: Angelantoni Industrie S.p.A.
    Inventors: Gianluigi Angelantoni, Pasquale De Blasio, Andrea Pedrazzini, Mauro Zenobi