With Specific Analytical Program Control Means Patents (Class 422/67)
  • Patent number: 11322013
    Abstract: A monitoring method of a manufacturing execution system (MES), a monitoring device, and a readable storage medium are provided. The monitoring method of the MES includes: reading log files of applications of an MES distributed on multiple servers and monitoring business operation information of the MES according to the log files. Based on this, this can make up for a gap in MES service monitoring and timely respond to abnormal production conditions. In addition, operators do not need to perform log query on each server.
    Type: Grant
    Filed: December 4, 2019
    Date of Patent: May 3, 2022
    Assignee: SHENZHEN CHINA STAR OPTOELECTRONICS SEMICONDUCTOR DISPLAY TECHNOLOGY CO., LTD.
    Inventor: Junlong Su
  • Patent number: 11313870
    Abstract: A method of operating an analytical laboratory is presented. The method comprises the steps of: setting a load limit for each laboratory instrument at maximum instrument capacity; dispatching biological samples to laboratory instrument(s) at a dispatch rate not greater than the instrument load limit; each laboratory instrument sending test order queries to the laboratory middleware upon identifying a biological sample; in response to the test order queries transmitting test orders to the laboratory instruments corresponding to the biological samples; the laboratory middleware monitoring a query rate of the plurality of laboratory instruments in order to determine an effective flow rate corresponding to each laboratory instrument; decreasing the load limit of a first laboratory instrument if its effective flow rate is lower than the dispatch rate; increasing the load limit for the first laboratory instrument if its effective flow rate is greater than or equal to the dispatch rate.
    Type: Grant
    Filed: October 28, 2020
    Date of Patent: April 26, 2022
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Frederic Furrer, Marco Maetzler
  • Patent number: 11275095
    Abstract: A sample pretreatment apparatus includes: a plurality of sample pretreatment sections, each of which executes a sample pretreatment prior to a measurement; and a robotic arm including: an articulated arm member; and a hand attached to the articulated arm member. The plurality of sample pretreatment sections includes a sample dispenser that dispenses a sample in a first sample container into a second sample container. For a first measurement, the robotic arm holds the second sample container with the hand and transports the second sample container to a pretreatment group of the plurality of sample pretreatment sections, the pretreatment group including the sample dispenser. For a second measurement, the robotic arm holds the second sample container with the hand and transports the second sample container to another pretreatment group of the plurality of sample pretreatment sections, the another pretreatment group including the sample dispenser.
    Type: Grant
    Filed: March 28, 2019
    Date of Patent: March 15, 2022
    Assignees: SYSMEX CORPORATION, KAWASAKI JUKOGYO KABUSHIKI KAISHA
    Inventors: Takashi Yoshida, Hiroaki Inokuchi, Takehiro Hasegawa, Chikako Murata, Yukio Iwasaki, Satoshi Ouchi
  • Patent number: 11209445
    Abstract: A blood testing apparatus includes an analyzer configured to analyze blood components of an animal that are included in a test medium; an output device configured to display analysis results of the blood components; and a controller configured to determine a species of the animal based on at least one from among types of the blood components and the analysis results of the blood components and control the output device to display the determined species of the animal.
    Type: Grant
    Filed: February 14, 2019
    Date of Patent: December 28, 2021
    Assignee: SAMSUNG ELECTRONICS CO., LTD.
    Inventors: Eun Jeong Jang, Ki Ju Lee
  • Patent number: 11161118
    Abstract: The mixing of reagents with each other in the reagent storage flow paths of an automatic analyzer is suppressed before and after exchange of the reagents, which are capable of being replenished without stopping analysis. An exchangeable reagent container that accommodates a reagent is connected to a reagent storage flow path that stores a portion of the reagent. The reagent storage flow path has first and second flow paths in which the second flow path is branched from the first flow path. A reagent syringe applies a negative or a positive pressure to the first and second flow paths; and a valve controls the flow path through which the reagent is sent. As a result, the reagent supplied to a measurement portion at a predetermined timing is switched from the reagent container to the reagent storage flow path wherein the reagent can be supplied without stopping analysis.
    Type: Grant
    Filed: February 15, 2018
    Date of Patent: November 2, 2021
    Assignee: HITACHI HIGH-TECH CORPORATION
    Inventors: Hiroki Fujita, Toshiharu Suzuki, Takenori Okusa, Shunsuke Sasaki, Yoshihiro Yamashita, Kenta Imai
  • Patent number: 11137336
    Abstract: A flow cytometer module configured to be integrated with a liquid handling system is provided herein. The flow cytometer module includes (a) a flow cell, (b) a first fluidic pathway, (c) an inlet configured to receive a sample introduction device of the liquid handling system including one or more samples, (d) a second fluidic pathway in fluid communication with the first fluidic pathway, (e) a laser interrogation device configured to examine the one or more samples at a laser interrogation point in the second fluidic pathway, and (f) a controller in communication with the liquid handling system and configured to cause the flow cytometer module to perform functions comprising: (i) recording data from the laser interrogation device corresponding to a plurality of events as the one or more samples pass the laser interrogation point, and (ii) transmitting the data corresponding to the plurality of events to the liquid handling system.
    Type: Grant
    Filed: October 31, 2018
    Date of Patent: October 5, 2021
    Assignee: Essen Instruments, Inc.
    Inventor: Stephen Barnes
  • Patent number: 11130123
    Abstract: Pipette tip couplers, pipette tips, coupler and tip combinations, and methods for coupling and decoupling a pipette tip to or from, respectively, a pipette tip coupler mounted on a pipette device. The pipette tip couplers include an elastomeric element, an annular crown shaped raceway, and a coupler stop shoulder surface. The pipette tips include a groove in a first cylindrical section, a second cylindrical section, a tip stop shoulder surface at the interface of the first and second cylindrical sections, a third cylindrical section, a sealing seat surface at the interface of the second and third cylindrical sections, and a fourth section adjacent to the third cylindrical section. When the pipette tip is mounted on the pipette tip coupler, the annular crown shaped raceway abuts the tip groove, the coupler stop shoulder surface abuts the tip stop shoulder surface, and the elastomeric element abuts the sealing seat surface.
    Type: Grant
    Filed: April 7, 2020
    Date of Patent: September 28, 2021
    Assignee: Hamilton Company
    Inventors: Jose Eduardo Guzman, Thomas Barresi, Dana A. Belton
  • Patent number: 11130126
    Abstract: There is provided a fluid analysis chamber module that allows an analysis element to be replaced in a sliding manner. The module includes a middle body, an upper body, and a lower body, in which the upper body and the lower body are rotated to be in contact with an upper surface and a lower surface of the middle body and to release from the contact state. The middle body provides a chamber hole where a tray with the analysis element seated thereon can be mounted. The middle body is provided on its front end with a tray receiving opening through which the tray is mounted into the chamber hole. When the upper body and lower body are rotated to be in contact with the upper surface and the lower surface, respectively, the chamber hole is closed, a fluid supplying line and discharging line are sealed, pogo pins for power supply and signal transmission are contacted to electrodes of the analysis element.
    Type: Grant
    Filed: July 24, 2019
    Date of Patent: September 28, 2021
    Assignee: Kookmin University Industry Academy Cooperation Foundation
    Inventors: Si Hyung Lim, Jang Hyeon Lee, Yeong Seok Lee, Ae Ran Song
  • Patent number: 11125673
    Abstract: Described are systems and methods for optical characterization of inclusions, such as solids and liquids, in liquid samples. An inclusion characterization system may include a radiation source, a radiation detector, a sample optical cell, and a sample delivery mechanism. The radiation detector may be configured to perform time resolved measurements. The sample may be delivered to the sample optical cell by the sample delivery mechanism at a flow rate set for preserving the sample integrity (i.e., the transport rate). The inclusion characterization in the sample may be performed at flow rates set for sample analysis (i.e., the analysis rate). The analysis rate may differ from the transport rate. The rate difference may be achieved by diverting only a portion of the overall sample into the sample optical cell. Also provided are examples of disengagement of sample transport and analysis flow rates.
    Type: Grant
    Filed: June 1, 2020
    Date of Patent: September 21, 2021
    Inventor: Rashid Mavliev
  • Patent number: 11117125
    Abstract: Pipette tip couplers, pipette tips, coupler and tip combinations, and methods for coupling and decoupling a pipette tip to or from, respectively, a pipette tip coupler mounted on a pipette device. The pipette tip couplers include an elastomeric element, a discrete segment assembly, and a coupler stop shoulder surface. The pipette tips include a groove in a first cylindrical section, a second cylindrical section, a tip stop shoulder surface at the interface of the first and second cylindrical sections, a third cylindrical section, a sealing seat surface at the interface of the second and third cylindrical sections, and a fourth section adjacent to the third cylindrical section. When the pipette tip is mounted on the pipette tip coupler, the discrete segment assembly abuts the tip groove, the coupler stop shoulder surface abuts the tip stop shoulder surface, and the elastomeric element abuts the sealing seat surface.
    Type: Grant
    Filed: April 23, 2019
    Date of Patent: September 14, 2021
    Assignee: Hamilton Company
    Inventors: Jose Eduardo Guzman, Thomas Barresi, Dana A. Belton
  • Patent number: 11099175
    Abstract: Apparatus and methods are described for use with a blood sample (48, 50), including measuring hemoglobin concentration within at least a portion (48) of the blood sample, by performing a first measurement on the blood sample. Mean corpuscular hemoglobin in the blood sample (48, 50) is measured, by performing a second measurement on the blood sample (48, 50). A parameter of the blood sample is determined, based on a relationship between the concentration of hemoglobin and the mean corpuscular hemoglobin. Other applications are also described.
    Type: Grant
    Filed: May 11, 2017
    Date of Patent: August 24, 2021
    Assignee: S.D. Sight Diagnostics Ltd.
    Inventors: Amir Zait, Arnon Houri Yafin, Dan Gluck, Sharon Pecker, Yochay Shlomo Eshel, Sarah Levy Schreier, Joseph Joel Pollak
  • Patent number: 11067590
    Abstract: A sample dispensing mechanism configured to dispense a sample and a reagent to the reaction vessel at a first dispensing position and the reaction cell positioned at a second dispensing position; a second reagent vessel disposed on a track of the sample dispensing mechanism; and a control unit configured to control the sample dispensing mechanism, in which the control unit is configured to, based on information on presence or absence of incubation of an analysis item, control the sample dispensing mechanism to dispense a sample and a reagent to the reaction vessel positioned at the first dispensing position in a case where the incubation is not required by the analysis item, and control the sample dispensing mechanism to dispense a sample to the reaction cell positioned at the second dispensing position in a case where the incubation is required by the analysis item.
    Type: Grant
    Filed: May 11, 2018
    Date of Patent: July 20, 2021
    Assignee: HITACHI HIGH-TECH CORPORATION
    Inventors: Rei Konishi, Akihisa Makino
  • Patent number: 11067587
    Abstract: To reduce the risk of mistaken operation and improve convenience in an automatic analysis device. Information about types of measurement inputted from an input device is combined in an examination mode creation screen image 301 on a display device of an automatic analysis device that performs analysis of specific types of measurement on a specimen container accommodating a specimen, the information about types of measurement including biochemistry examination items 303, immunology examination items 304, ISE examination items 304, blood clotting examination items 306, etc. This information is associated with an examination mode name 302, which comprises discretionary setting information, and is stored in a table of a storage unit. Information which is to be displayed on the display device and for which a change in settings is to be enabled is limited on the basis of the stored information about types of measurement associated with the examination mode name 302.
    Type: Grant
    Filed: May 31, 2018
    Date of Patent: July 20, 2021
    Assignee: HITACHI HIGH-TECH CORPORATION
    Inventor: Akira Joji
  • Patent number: 11060081
    Abstract: Disclosed is a specimen pretreatment apparatus comprising: a specimen container holder configured to hold a specimen container for containing a plasma specimen; a reagent container holder configured to hold a first reagent container for containing a first reagent including magnetic particles on which a nucleic acid in the plasma specimen is adsorbed; a reaction unit in which a plurality of reaction containers are disposed, the reaction unit being configured to accelerate, in each reaction container, reaction of the plasma specimen and the first reagent; a washing unit in which a washing container is disposed, the washing unit including a magnetic force applying portion configured to apply magnetic force to the washing container; a dispensing unit; and a controller programmed to control the dispensing unit to: dispense the plasma specimen contained in the specimen container and the first reagent into the plurality of reaction containers in the reaction unit; dispense a mix liquid of the plasma specimen and the
    Type: Grant
    Filed: February 27, 2017
    Date of Patent: July 13, 2021
    Assignee: SYSMEX CORPORATION
    Inventors: Yasuhiro Sakai, Hiroaki Tobimatsu, Takeo Saitou, Tomoko Ohyama, Takanori Maekawa
  • Patent number: 10955389
    Abstract: A sample introduction device 100 includes a heating unit 102, an ultraviolet irradiation unit 103, and a sample supply part 106. The heating unit 102 vaporizes a sample 22 by heating externally a container 2 in which the sample 22 is enclosed. The ultraviolet irradiation unit 103 causes ultraviolet rays to pass through the container 2 and irradiates the sample 22 with the ultraviolet rays. The sample supply part 106 supplies the sample vaporized in the container 2 to a gas chromatograph 1 side.
    Type: Grant
    Filed: March 7, 2016
    Date of Patent: March 23, 2021
    Assignee: SHIMADZU CORPORATION
    Inventors: Akira Aono, Isao Sawamura
  • Patent number: 10908175
    Abstract: A sample analyzer is configured to execute a liquid surface detection of detecting a liquid surface in a container by a liquid surface detector prior to a lowering operation of an aspirating tube for aspirating the liquid if a liquid level information is not stored in a memory, and store a liquid level information of a container in the memory based on a detection result by the liquid surface detection. Also, a liquid aspirating method by a sample analyzer.
    Type: Grant
    Filed: November 23, 2016
    Date of Patent: February 2, 2021
    Assignee: SYSMEX CORPORATION
    Inventors: Hiroshi Kurono, Takashi Yamato
  • Patent number: 10878384
    Abstract: The present invention relates to a device maintainer, a device maintenance system, a device maintenance method, a device maintenance program, and a recording medium, which are capable of supporting an accurate operation and improving an operation efficiency in the maintenance operation of the device or a recording operation of the maintenance result. A device maintainer having a maintenance information display for displaying maintenance information regarding a maintenance of a device; a list display for displaying a maintenance list listing a maintenance item for the device to be a maintenance target together with the displayed maintenance information and enabling designation of the maintenance item; and a maintainer for performing the maintenance based on the designated maintenance item for the device to be the maintenance target.
    Type: Grant
    Filed: March 7, 2017
    Date of Patent: December 29, 2020
    Assignee: Yokogawa Electric Corporation
    Inventors: Ryouhei Furihata, Yusuke Yokota
  • Patent number: 10866254
    Abstract: A system that rapidly detects the presence of a target analyte in a biological test sample, which includes a sensor for measuring a detectable signal generated upon the reaction of a biosensor reagent with a specific target analyte within the sample; a reservoir card that includes the biosensor reagent that further includes living, engineered biological cells, and wherein the reservoir card is configured to interface with a test cartridge base; a test cartridge base configured to accept the reservoir card and to be placed within the testing device, wherein the test cartridge base further includes a reaction chamber adapted to receive both the biosensor reagent and the sample and a fluid displacement mechanism that includes a dispensing plunger, wherein actuation of the dispensing plunger displaces the biosensor reagent in the reservoir into the reaction chamber where the biosensor reagent is mixed with the sample; and a function verification cartridge adapted to be received and recognized by the testing devic
    Type: Grant
    Filed: April 16, 2018
    Date of Patent: December 15, 2020
    Assignee: Fundamental Solutions Corporation
    Inventors: Christopher T. Phelan, Stephan M. Lawson, Andrew Weiman, Marvin R. Williams, Charles McBrairty, Joel S. Lwande
  • Patent number: 10837976
    Abstract: The sample analyzer includes: a reagent arranging section for arranging a plurality of reagents; an analyzing section for analyzing a measurement sample prepared by mixing a sample and the reagent arranged on the reagent arranging section; a display device; an input device; and a display control section for displaying a reagent arrangement displaying region for displaying a plurality of reagent marks inscribed with a reagent name respectively on the display device, wherein the each reagent mark is displayed in a manner selectable by the input device, wherein arrangement of the each reagent mark on the reagent arrangement displaying region corresponds to arrangement of the each reagent on the reagent arranging section, wherein the display control section displays detailed information related to the reagent corresponding to the reagent mark selected by the input device on the display device.
    Type: Grant
    Filed: September 21, 2018
    Date of Patent: November 17, 2020
    Assignee: Sysmex Corporation
    Inventors: Hiroyuki Fujino, Kyozo Fujita, Mitsuyo Ito
  • Patent number: 10732089
    Abstract: A flow cytometer apparatus and methods for detecting and clearing a clog therein are disclosed. An example method for detecting a clog may include (i) detecting, via a fault detection system of a flow cytometer, a first plurality of events associated with a first aliquot from a first sample well, (ii) determining a count of the first plurality of events associated with the first aliquot, (iii) determining whether the count of the first plurality of events is below a minimum count tolerance and (iv) (a) if the count of the first plurality of events is below the minimum count tolerance, then determining that the flow cytometer has a clog, (b) if the count of the first plurality of events is equal to or above the minimum count tolerance, then detecting a second plurality of events associated with a second aliquot from a second sample well.
    Type: Grant
    Filed: July 31, 2018
    Date of Patent: August 4, 2020
    Assignee: Essen Instruments, Inc.
    Inventor: Aaron B. Kennington
  • Patent number: 10697943
    Abstract: An automatic analysis device capable of effectively preventing incorrect container number input when analysis conditions are set. An image display area and text display area are provided in a setting screen. An image in which a selection area is assigned to each container number corresponding to a sample container is displayed in the image display area. If a selection area in the image display area is selected through operation unit operation, the container number expressing the selected selection area is displayed in the text display area (container number input part). If the container number expressing the selected sample container is displayed in the text display area (container number input part) as a result of operation unit operation, the display mode of the selection area corresponding to the container number is switched.
    Type: Grant
    Filed: May 26, 2015
    Date of Patent: June 30, 2020
    Assignee: Shimadzu Corporation
    Inventor: Kohei Yamamoto
  • Patent number: 10684297
    Abstract: A method and system for automatic in-vitro diagnostic analysis are described. The method includes adding a first reagent type and a second reagent type to a first test liquid during a first and second cycle times respectively. The addition of the first reagent type to the first test liquid includes parallel addition of a second reagent type to a second test liquid during the first cycle time. The addition of the second reagent type to the first test liquid includes parallel addition of a first reagent type to a third test liquid during the second cycle time, respectively.
    Type: Grant
    Filed: February 13, 2019
    Date of Patent: June 16, 2020
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Thomas Meyer, Gottlieb Schacher, Rolf Sigrist, Christian Guzek
  • Patent number: 10656169
    Abstract: A method of reducing carryover of liquids, such as reagent and/or samples, in analytical or immunoassay testing. The method includes providing an incubation member including a plurality of reaction vessels thereon, pre-assigning certain ones of the reaction vessels in the incubation member for only first test types or certain reagent types for all test lots; and pre-assigning other ones of a second subset of reaction vessels in the incubation member for only second test types for all test lots. By ensuring no mixing of potentially interfering test types or reagent types from test lot to test lot, sample and/or reagent carryover is mitigated. Testing apparatus adapted to carry out the methods are provided, as are other aspects.
    Type: Grant
    Filed: May 26, 2015
    Date of Patent: May 19, 2020
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Jianfang Wang, Mark Sprenkle, Colin Ingersoll, Stephen Frye
  • Patent number: 10648973
    Abstract: An immunoassay apparatus may include: a sample dispenser part that dispenses a sample into a first reaction container; a reagent dispenser part that dispenses, into the first reaction container,: a solid-phase reagent containing a solid-phase carrier; a labeled reagent; and a releasing reagent that releases, from the solid-phase carrier, an immune complex including a target substance and a labeled substance; a measurement part that measures a signal based on the labeled substance in the immune complex in a second reaction container; a container supply part that stores a plurality of reaction containers; a transfer part that transfers the first reaction container so that the sample dispenser part and the reagent dispenser part perform a dispensing operation to the first reaction container, and that transfers the second reaction container so that the immune complex dispended from the first reaction container is dispensed into the second container.
    Type: Grant
    Filed: September 29, 2017
    Date of Patent: May 12, 2020
    Assignee: SYSMEX CORPROATION
    Inventors: Toshiyuki Sato, Toshikatsu Fukuju, Shuhei Kaneko, Atsushi Aoki, Tomohiro Okuzaki, Yasuhiro Takeuchi, Yutaka Kawamoto
  • Patent number: 10605818
    Abstract: The purpose of the present invention is to stably hold the lid of a reagent container in an open state without being influenced by reagent container lid opening and closing operations. An automated analyzer is provided with reagent containers 116-118, a cassette 100, a reagent container lid opening and closing mechanism, and a lid holding mechanism 131. The reagent containers 116-118 accommodate the reagent and have lids 101a-101c that pivot about a pivot point. The reagent containers 116-118 are mounted on the cassette 100. The reagent container lid opening and closing mechanism opens and closes the lids 101a-101c. The lid holding mechanism 131 holds the lids 101a opened by the reagent container lid opening and closing mechanism.
    Type: Grant
    Filed: July 8, 2016
    Date of Patent: March 31, 2020
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Kazuhiro Noda, Yukinori Sakashita, Takushi Miyakawa, Katsuhiro Kambara
  • Patent number: 10583413
    Abstract: A reactor includes a reaction unit, a first pipe, a second pipe, a composition analysis unit connected to the first pipe, a regulating unit connected to the second pipe so as to regulate a flow rate or the like of a second fluid, a control unit causing the regulating unit to regulate the flow rate or the like of the second fluid in accordance with a composition of a product analyzed by the composition analysis unit so that a temperature of a third fluid is controlled to lead the composition of the product to keep a predetermined reaction rate or yield, and a first temperature measurement unit connected to the first pipe so as to measure the temperature of the third fluid. The control unit acquires the information on the temperature of the third fluid from the first temperature measurement unit.
    Type: Grant
    Filed: April 23, 2019
    Date of Patent: March 10, 2020
    Assignee: IHI CORPORATION
    Inventors: Taiga Yamamoto, Shigeki Sakakura, Akihisa Yano, Takahito Akita, Shunji Miyajima, Tatsuya Oka, Hideshi Shibuya, Yusuke Takeuchi
  • Patent number: 10583469
    Abstract: The amount of consumption of a washing solution for a nozzle and the required time for washing are reduced. A nozzle washing apparatus usable for collection of a specimen comprises a washing tank which accommodates a nozzle, a first discharge port which discharges a washing solution supplied into the washing tank from an upper portion of the washing tank, a second discharge port which discharges the washing solution supplied into the washing tank from a position lower than the first discharge port of the washing tank, a detector which detects a range of contact of an outer wall of the nozzle with the specimen, and a controller which discharges the washing solution supplied into the washing tank from one of the first discharge port and the second discharge port on the basis of a detection result obtained by the detector.
    Type: Grant
    Filed: June 25, 2018
    Date of Patent: March 10, 2020
    Assignee: ARKRAY, Inc.
    Inventor: Shinichi Ota
  • Patent number: 10533993
    Abstract: The invention provides a test strip comprising an identification region coded a screen function of the test strip by a chromaticity coordinates model; a calibration region having a particular color for calibrating an external spectrum analyzer; and a reaction region chemically reacted with a specific specimen for changing its own color. By using the external spectrum analyzer to conduct light splitting of the reflective lights from the recognition and reaction regions of the test strip, automatic recognition and simplified usage can be achieved.
    Type: Grant
    Filed: September 5, 2016
    Date of Patent: January 14, 2020
    Inventor: Cheng-Hao Ko
  • Patent number: 10507411
    Abstract: A device to extract a near continuous stream of sample water from a high solids content source for the purpose of delivery to a liquid analyzer or sensor for test or measurement. The device includes a source of compressed air and a source of chemical cleaning agent that are used in a coordinated effort to purge and clean the sampling system to ensure the water stream is maintained over long periods of time without significant human intervention. The device includes a valve to allow compressed air to intermittently be sent backwards through the sampling line to purge to drain an inline strainer of solids that have built up since the previous air purge. Downstream of the air valve another valve is used to introduce cleaning chemical into the sampling system to clean residual buildup downstream of the inline strainer. A debubbler unit is placed between the air valve and the cleaning chemical valve to remove air from the sampling system after it was introduced during the air purge event.
    Type: Grant
    Filed: October 3, 2017
    Date of Patent: December 17, 2019
    Assignee: 2134761 ONTARIO LTD.
    Inventors: James Andrew Glover, Richard Hibbs
  • Patent number: 10309899
    Abstract: A device for determining an assay result may include a test strip, a light source system, a light detection system, and a processor.
    Type: Grant
    Filed: February 27, 2018
    Date of Patent: June 4, 2019
    Assignee: Alere Switzerland GmbH
    Inventors: Stephen P. Sharrock, Andrew P. Phelan
  • Patent number: 10156580
    Abstract: A sample processing system that may be automated and methods are disclosed where samples are arranged on a carrier element and a process operation control system automatically processes the samples perhaps robotically with an operationally-influential exteriorly-consequential information monitor or a data capture element. Significant process details as well as operationally-influential exteriorly-consequential information may be monitored and an automatic notice element may cause notification of a person at some display that may be remote. Various people may be notified, such as an administrator, a supplier, or a manufacturer of an opportunity for some action such as reagent reordering or the like. A simulated motion display may be included to “watch” simulated operation in real time or long after completion of the actual processing.
    Type: Grant
    Filed: December 4, 2015
    Date of Patent: December 18, 2018
    Assignee: DAKO DENMARK A/S
    Inventors: Gordon Feingold, Marc Key, John Favuzzi, Rosanne Welcher
  • Patent number: 10078070
    Abstract: An analyzer, and a method and an apparatus for detecting liquid overflowing from a container that the analyzer comprises, are provided. The method according to the present invention for detecting liquid overflowing from a container in the analyzer, includes a step of judging that liquid is overflowing from at least one container if the difference between a standard deviation of absorbance of the liquid measured at a plurality of points of a container at time T1 and a standard deviation of absorbance of the liquid measured at a plurality of points in said container at time T2 is greater than a predetermined threshold value.
    Type: Grant
    Filed: February 17, 2012
    Date of Patent: September 18, 2018
    Assignee: Beckman Coulter, Inc.
    Inventors: Yoshiaki Hashimoto, Noriyoshi Okada
  • Patent number: 10048191
    Abstract: A flow cytometer apparatus and methods for detecting and clearing a clog therein are disclosed. An example method for detecting a clog may include (i) detecting, via a fault detection system of a flow cytometer, a first plurality of events associated with a first aliquot from a first sample well, (ii) determining a count of the first plurality of events associated with the first aliquot, (iii) determining whether the count of the first plurality of events is below a minimum count tolerance and (iv) (a) if the count of the first plurality of events is below the minimum count tolerance, then determining that the flow cytometer has a clog, (b) if the count of the first plurality of events is equal to or above the minimum count tolerance, then detecting a second plurality of events associated with a second aliquot from a second sample well.
    Type: Grant
    Filed: January 20, 2017
    Date of Patent: August 14, 2018
    Assignee: Intellicyt
    Inventor: Aaron B. Kennington
  • Patent number: 10012663
    Abstract: A display unit displays, on a single screen, a first display area configured from a first area corresponding to the position on a reagent disc at which a reagent container is disposed and a second display area configured from a second area corresponding to the position on a reagent loader at which a reagent container is disposed. A control unit changes the display state of the first area on the basis of whether a reagent container is placed at a position on the reagent disk corresponding to the first area and reagent information for the reagent accommodated in the placed reagent container and changes the display state of the second area on the basis of whether a reagent container is placed at a position on the reagent loader corresponding to the second area and reagent-container-conveyance-state information for the placed reagent container.
    Type: Grant
    Filed: April 22, 2015
    Date of Patent: July 3, 2018
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Takaaki Hagiwara, Toshiharu Suzuki, Hiroki Fujita
  • Patent number: 9989544
    Abstract: A technique is disclosed for sample management for use in conjunction with sequencing devices that sequence biological samples, e.g., DNA and RNA. A sequencing device or a network of sequencing devices may be scheduled according to the characteristics of the samples in queue and the capabilities and availability of sequencing devices. Biological samples may be automatically queued and loaded via a sample distribution system. A sample distribution system may be used to reduce operator intervention.
    Type: Grant
    Filed: July 9, 2015
    Date of Patent: June 5, 2018
    Assignee: ILLUMINA, INC.
    Inventors: Robert C. Kain, Alexander G. Dickinson, Min-Jui Richard Shen, Helmy A. Eltoukhy, Francisco Jose Garcia
  • Patent number: 9964553
    Abstract: A blood testing apparatus includes a loader configured to receive a test medium, the test medium including a test object to be tested; a controller configured to perform control to operate the loader to receive the test medium in response to receiving an input of a trigger signal indicating a test start in an emergency mode; a display configured to display a user interface screen indicating the emergency mode; and an analyzer configured to automatically start analysis of the test object under the control of the controller when the test medium is received.
    Type: Grant
    Filed: March 26, 2015
    Date of Patent: May 8, 2018
    Assignee: SAMSUNG ELECTRONICS CO., LTD.
    Inventors: Im-ho Shin, Jong-cheol Kim, Ki-ju Lee, Chung-ung Kim
  • Patent number: 9915673
    Abstract: A tube rack transfer device for transferring racks is presented. A first rail extends in a first horizontal direction and a second rail extends in a second horizontal direction orthogonal to the first direction. The second rail moves along the first rail and comprising a transfer head movable along the second rail. The transfer head comprises a control pin to be coupled with one of: an input pusher, translatable in the second direction, for transferring a rack from a carrier to a sampling area of an analyzer; an output pusher for transferring a rack from the sampling area to a carrier; a rack for transferring the rack between different carriers and/or between different positions of the same carrier. An in-vitro diagnostic instrument comprises an analyzer for carrying out tests on biological samples, a sample unit for inputting/outputting racks, a sampling area for withdrawing samples from tubes, and a transfer device.
    Type: Grant
    Filed: December 5, 2014
    Date of Patent: March 13, 2018
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Marco Bucher, Gottlieb Schacher
  • Patent number: 9914903
    Abstract: An automatic device for inoculating a sample on a substrate with a dilution mechanism formed by a head that holds a stylus in cooperation with a first dilution tank and a second dilution tank to dilute an original sample in at least one sub-sample and for inoculating the sub-sample on a substrate.
    Type: Grant
    Filed: September 13, 2012
    Date of Patent: March 13, 2018
    Assignee: INTERLAB
    Inventor: M. Emmanuel Jalenques
  • Patent number: 9874525
    Abstract: Disclosed herein are methods of producing a test element for studying a body fluid sample. In the methods, a detection layer is covered with a polymeric spreading layer and applied to a support. The spreading layer can be produced by being sprayed onto the detection layer such that the spreading layer has a thickness of at most about 20 ?m. Also disclosed are test elements produced by the methods, as well as tape cassettes incorporating such test elements.
    Type: Grant
    Filed: August 27, 2013
    Date of Patent: January 23, 2018
    Assignee: ROCHE DIABETES CARE, INC.
    Inventors: Joerg Dreibholz, Herbert Fink, Volker Huellen
  • Patent number: 9839086
    Abstract: A method is described for adjusting the brightness of at least one LED according to a changing supply voltage provided to the at least one LED includes acquiring a parameter which indicates the changing supply voltage; and providing, on the basis of the acquired parameter, a control voltage of the at least one LED for adjusting an LED current such that the at least one LED has a predefined relative brightness change over the predefined voltage range. A control unit and an LED lamp which implement the method described here are also discloses. Furthermore, an LED lighting apparatus and a medical diagnostic device having the LED lamp disclosed here are described.
    Type: Grant
    Filed: May 25, 2016
    Date of Patent: December 5, 2017
    Assignee: HEINE OPTOTECHNIK GMBH & CO KG
    Inventors: Norbert Merkt, Benjamin Komm, Manfred Wittlinger, Oliver Heine, Bernd Kabbeck
  • Patent number: 9784754
    Abstract: An automatic analyzer achieves both restraining unnecessary usage of a consumable supply and reducing burdens on an operator in a re-execution processing in a case where pipe functions are suspended/stopped, and is capable of completely efficiently performing an analysis preparation processing or an analysis terminating processing.
    Type: Grant
    Filed: November 11, 2013
    Date of Patent: October 10, 2017
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Osamu Matsumoto, Teruhiro Yamano
  • Patent number: 9581584
    Abstract: A diluted cleaning solution is contacted with the inner wall surface of an immunity measuring cell every time an immunity measurement treatment of a specimen is performed. Therefore, a diluting liquid is injected in advance, then a cleaning solution is injected, whereby a diluted cleaning solution is produced in the immunity measuring cell. As a result, the inner wall surface of the immunity measuring cell is maintained in a preferable state and the interval of the routine cleanings can be prolonged.
    Type: Grant
    Filed: May 15, 2014
    Date of Patent: February 28, 2017
    Assignee: HORIBA, Ltd.
    Inventor: Kazumasa Takemoto
  • Patent number: 9527085
    Abstract: The invention relates generally to the field of automated collection and deposition of fluid, semi-solid, and solid samples of biological or chemical materials. More specifically, the invention relates to the field of microarrayers, which are devices for autonomously depositing minute droplets of biological or chemical fluid samples in ordered arrays onto substrates. The invention also relates to tissue arrayers, which are devices for the collection and deposition of solid and semi-solid tissue samples in ordered arrays. Other aspects of the invention relate to fluidics robots, which are devices for the autonomous collection, dispensing and processing of biological or chemical fluid samples. The invention improves the throughput of microarrayers, tissue arrayers, and fluidics robots by providing methods and apparatuses to precisely and repeatably load supplies into the machines.
    Type: Grant
    Filed: August 5, 2009
    Date of Patent: December 27, 2016
    Assignee: Aushon Biosystems, Inc.
    Inventors: John Austin, Peter D. Honkanen
  • Patent number: 9522205
    Abstract: In a low temperature hydrogen peroxide gas plasma sterilizer, the accurate control of concentration of the hydrogen peroxide sterilant is an important factor in determining reliability and sterilization efficacy of the sterilization process. The present application describes sterilizers, and sterilization methods, which use a novel injector-concentrator arrangement which allows accurate concentration of the sterilant performed concurrently with the sterilization process. This process enables the device to sterilize wide range of sensitive equipment within a shorter sterilization cycle.
    Type: Grant
    Filed: August 1, 2013
    Date of Patent: December 20, 2016
    Assignee: GETINGE STERICOOL MEKICAL ALTETLER SAN. VE TIC. A.S.
    Inventor: Fatih Ahiska
  • Patent number: 9464970
    Abstract: The invention relates inter alia to an automated stainer for staining, in particular for hemalum-eosin (HE) staining, of a histological sample, the automated stainer exposing the sample to the action of at least one stain using at least one staining parameter. The automated stainer is notable for the fact that the automated stainer comprises an input means with which a staining parameter is definable, in particular is inputtable or is selectable from a plurality of possible staining parameters; and that a control apparatus is present which, upon application of the defined staining parameter, ascertains the prospectively expectable outcome of an action and displays it to the user with a display apparatus, before the automated stainer actually stains the sample.
    Type: Grant
    Filed: September 10, 2013
    Date of Patent: October 11, 2016
    Assignee: Leica Biosystems Nussloch GmbH
    Inventor: Markus Berberich
  • Patent number: 9417253
    Abstract: A specimen processing system comprising: a specimen measuring section for measuring specimens accommodated in specimen containers; a transport section for transporting specimen containers to the specimen measuring section; a specimen container collect section for collecting specimen containers; an obtainer for obtaining shape information on specimen containers or state information on specimens accommodated in specimen containers; a supply judger configured for determining whether specimen containers are to be supplied to the specimen measuring section on the basis of the result obtained by the obtainer; and a delivery section for delivering specimen containers, which are determined to be supplied to the specimen measuring section by the supply judger, toward the transport section, and delivering specimen containers, which are determined not to be supplied to the specimen measuring section by the supply judger, toward the specimen container collect section, is disclosed.
    Type: Grant
    Filed: October 28, 2009
    Date of Patent: August 16, 2016
    Assignee: SYSMEX CORPORATION
    Inventors: Yasuo Yonekura, Yuichiro Ohmae, Tokihiro Kosaka, Takaaki Nagai
  • Patent number: 9329193
    Abstract: A sample processing apparatus for performing a process including a plurality of steps on a sample, the sample processing apparatus sequentially processing a plurality of samples, is disclosed. The apparatus comprises a plurality of units corresponding to the respective steps in the process; a transfer section which transfers a sample to the units according to a flow of the steps; and a controller. Specifically, when an operation was not performed successfully, the controller interrupts the process for a sample that had not reached the location where the unsuccessful operation was performed while continuing the process for a sample that had already passed the location, retries the operation that was not performed successfully, and resumes the interrupted process when the retried operation has been performed successfully.
    Type: Grant
    Filed: September 12, 2011
    Date of Patent: May 3, 2016
    Assignee: SYSMEX CORPORATION
    Inventors: Hiromi Onomichi, Mitsuo Yamasaki
  • Patent number: 9316658
    Abstract: A sample processing apparatus comprising: a plurality of testing units arranged along a transport path and each configured to perform at least one type of test; a plurality of transport units configured to collectively constitute the transport path and collectively function to deliver samples to the plurality of testing units for testing; and at least one processor of a computer system and at least one memory that stores programs executable by the at least one processor to: (a) determine a type of test required to be performed on a sample; (b) if a trouble of a transport unit is reported, determine whether there is an available testing unit performable of the required type of test to which the sample is deliverable; (c) if there is the available testing unit, instruct to transport the sample to the available testing unit.
    Type: Grant
    Filed: March 28, 2011
    Date of Patent: April 19, 2016
    Assignee: SYSMEX CORPORATION
    Inventor: Hiroo Tatsutani
  • Patent number: 9285380
    Abstract: The invention relates to a measurement system MS1 provided with a plurality of loading units 10 into which a measurement tool 4 supporting a reagent is loaded. The measurement system MS1 includes reading means 2 for reading information on an analyte provider that includes identification information, and guidance means 11 for guiding the measurement tool 4 to which an analyte derived from the analyte provider has been or is to be applied, to a loading unit that is selected from the plurality of loading units 10 and individually associated with the analyte provider based on the identification information that has been read by the reading means 2. With such configuration, the measurement results obtained from the analyte derived from the analyte provider can be easily associated with the information on the analyte provider that includes the identification information.
    Type: Grant
    Filed: November 22, 2010
    Date of Patent: March 15, 2016
    Assignee: ARKRAY, Inc.
    Inventors: Tokuo Kasai, Takashi Nakagawa, Minoru Kotaki
  • Patent number: 9255937
    Abstract: Provided is an automatic analyzer that includes a suction nozzle, a detection container, and a detector. The suction nozzle suctions a sample and a solution used for the detection of the sample. The suctioned sample and the solution are supplied to the detection container. The detector detects a signal from the sample. In addition, a vessel for the sample and a container for the solution are disposed below the detection container.
    Type: Grant
    Filed: July 20, 2011
    Date of Patent: February 9, 2016
    Assignee: HITACHI HIGH TECHNOLOGIES CORPORATION
    Inventors: Yukinori Sakashita, Katsuaki Takahashi, Yoshihiro Yamashita, Taku Sakazume