With Specific Analytical Program Control Means Patents (Class 422/67)
  • Patent number: 10732089
    Abstract: A flow cytometer apparatus and methods for detecting and clearing a clog therein are disclosed. An example method for detecting a clog may include (i) detecting, via a fault detection system of a flow cytometer, a first plurality of events associated with a first aliquot from a first sample well, (ii) determining a count of the first plurality of events associated with the first aliquot, (iii) determining whether the count of the first plurality of events is below a minimum count tolerance and (iv) (a) if the count of the first plurality of events is below the minimum count tolerance, then determining that the flow cytometer has a clog, (b) if the count of the first plurality of events is equal to or above the minimum count tolerance, then detecting a second plurality of events associated with a second aliquot from a second sample well.
    Type: Grant
    Filed: July 31, 2018
    Date of Patent: August 4, 2020
    Assignee: Essen Instruments, Inc.
    Inventor: Aaron B. Kennington
  • Patent number: 10697943
    Abstract: An automatic analysis device capable of effectively preventing incorrect container number input when analysis conditions are set. An image display area and text display area are provided in a setting screen. An image in which a selection area is assigned to each container number corresponding to a sample container is displayed in the image display area. If a selection area in the image display area is selected through operation unit operation, the container number expressing the selected selection area is displayed in the text display area (container number input part). If the container number expressing the selected sample container is displayed in the text display area (container number input part) as a result of operation unit operation, the display mode of the selection area corresponding to the container number is switched.
    Type: Grant
    Filed: May 26, 2015
    Date of Patent: June 30, 2020
    Assignee: Shimadzu Corporation
    Inventor: Kohei Yamamoto
  • Patent number: 10684297
    Abstract: A method and system for automatic in-vitro diagnostic analysis are described. The method includes adding a first reagent type and a second reagent type to a first test liquid during a first and second cycle times respectively. The addition of the first reagent type to the first test liquid includes parallel addition of a second reagent type to a second test liquid during the first cycle time. The addition of the second reagent type to the first test liquid includes parallel addition of a first reagent type to a third test liquid during the second cycle time, respectively.
    Type: Grant
    Filed: February 13, 2019
    Date of Patent: June 16, 2020
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Thomas Meyer, Gottlieb Schacher, Rolf Sigrist, Christian Guzek
  • Patent number: 10656169
    Abstract: A method of reducing carryover of liquids, such as reagent and/or samples, in analytical or immunoassay testing. The method includes providing an incubation member including a plurality of reaction vessels thereon, pre-assigning certain ones of the reaction vessels in the incubation member for only first test types or certain reagent types for all test lots; and pre-assigning other ones of a second subset of reaction vessels in the incubation member for only second test types for all test lots. By ensuring no mixing of potentially interfering test types or reagent types from test lot to test lot, sample and/or reagent carryover is mitigated. Testing apparatus adapted to carry out the methods are provided, as are other aspects.
    Type: Grant
    Filed: May 26, 2015
    Date of Patent: May 19, 2020
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Jianfang Wang, Mark Sprenkle, Colin Ingersoll, Stephen Frye
  • Patent number: 10648973
    Abstract: An immunoassay apparatus may include: a sample dispenser part that dispenses a sample into a first reaction container; a reagent dispenser part that dispenses, into the first reaction container,: a solid-phase reagent containing a solid-phase carrier; a labeled reagent; and a releasing reagent that releases, from the solid-phase carrier, an immune complex including a target substance and a labeled substance; a measurement part that measures a signal based on the labeled substance in the immune complex in a second reaction container; a container supply part that stores a plurality of reaction containers; a transfer part that transfers the first reaction container so that the sample dispenser part and the reagent dispenser part perform a dispensing operation to the first reaction container, and that transfers the second reaction container so that the immune complex dispended from the first reaction container is dispensed into the second container.
    Type: Grant
    Filed: September 29, 2017
    Date of Patent: May 12, 2020
    Assignee: SYSMEX CORPROATION
    Inventors: Toshiyuki Sato, Toshikatsu Fukuju, Shuhei Kaneko, Atsushi Aoki, Tomohiro Okuzaki, Yasuhiro Takeuchi, Yutaka Kawamoto
  • Patent number: 10605818
    Abstract: The purpose of the present invention is to stably hold the lid of a reagent container in an open state without being influenced by reagent container lid opening and closing operations. An automated analyzer is provided with reagent containers 116-118, a cassette 100, a reagent container lid opening and closing mechanism, and a lid holding mechanism 131. The reagent containers 116-118 accommodate the reagent and have lids 101a-101c that pivot about a pivot point. The reagent containers 116-118 are mounted on the cassette 100. The reagent container lid opening and closing mechanism opens and closes the lids 101a-101c. The lid holding mechanism 131 holds the lids 101a opened by the reagent container lid opening and closing mechanism.
    Type: Grant
    Filed: July 8, 2016
    Date of Patent: March 31, 2020
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Kazuhiro Noda, Yukinori Sakashita, Takushi Miyakawa, Katsuhiro Kambara
  • Patent number: 10583469
    Abstract: The amount of consumption of a washing solution for a nozzle and the required time for washing are reduced. A nozzle washing apparatus usable for collection of a specimen comprises a washing tank which accommodates a nozzle, a first discharge port which discharges a washing solution supplied into the washing tank from an upper portion of the washing tank, a second discharge port which discharges the washing solution supplied into the washing tank from a position lower than the first discharge port of the washing tank, a detector which detects a range of contact of an outer wall of the nozzle with the specimen, and a controller which discharges the washing solution supplied into the washing tank from one of the first discharge port and the second discharge port on the basis of a detection result obtained by the detector.
    Type: Grant
    Filed: June 25, 2018
    Date of Patent: March 10, 2020
    Assignee: ARKRAY, Inc.
    Inventor: Shinichi Ota
  • Patent number: 10583413
    Abstract: A reactor includes a reaction unit, a first pipe, a second pipe, a composition analysis unit connected to the first pipe, a regulating unit connected to the second pipe so as to regulate a flow rate or the like of a second fluid, a control unit causing the regulating unit to regulate the flow rate or the like of the second fluid in accordance with a composition of a product analyzed by the composition analysis unit so that a temperature of a third fluid is controlled to lead the composition of the product to keep a predetermined reaction rate or yield, and a first temperature measurement unit connected to the first pipe so as to measure the temperature of the third fluid. The control unit acquires the information on the temperature of the third fluid from the first temperature measurement unit.
    Type: Grant
    Filed: April 23, 2019
    Date of Patent: March 10, 2020
    Assignee: IHI CORPORATION
    Inventors: Taiga Yamamoto, Shigeki Sakakura, Akihisa Yano, Takahito Akita, Shunji Miyajima, Tatsuya Oka, Hideshi Shibuya, Yusuke Takeuchi
  • Patent number: 10533993
    Abstract: The invention provides a test strip comprising an identification region coded a screen function of the test strip by a chromaticity coordinates model; a calibration region having a particular color for calibrating an external spectrum analyzer; and a reaction region chemically reacted with a specific specimen for changing its own color. By using the external spectrum analyzer to conduct light splitting of the reflective lights from the recognition and reaction regions of the test strip, automatic recognition and simplified usage can be achieved.
    Type: Grant
    Filed: September 5, 2016
    Date of Patent: January 14, 2020
    Inventor: Cheng-Hao Ko
  • Patent number: 10507411
    Abstract: A device to extract a near continuous stream of sample water from a high solids content source for the purpose of delivery to a liquid analyzer or sensor for test or measurement. The device includes a source of compressed air and a source of chemical cleaning agent that are used in a coordinated effort to purge and clean the sampling system to ensure the water stream is maintained over long periods of time without significant human intervention. The device includes a valve to allow compressed air to intermittently be sent backwards through the sampling line to purge to drain an inline strainer of solids that have built up since the previous air purge. Downstream of the air valve another valve is used to introduce cleaning chemical into the sampling system to clean residual buildup downstream of the inline strainer. A debubbler unit is placed between the air valve and the cleaning chemical valve to remove air from the sampling system after it was introduced during the air purge event.
    Type: Grant
    Filed: October 3, 2017
    Date of Patent: December 17, 2019
    Assignee: 2134761 ONTARIO LTD.
    Inventors: James Andrew Glover, Richard Hibbs
  • Patent number: 10309899
    Abstract: A device for determining an assay result may include a test strip, a light source system, a light detection system, and a processor.
    Type: Grant
    Filed: February 27, 2018
    Date of Patent: June 4, 2019
    Assignee: Alere Switzerland GmbH
    Inventors: Stephen P. Sharrock, Andrew P. Phelan
  • Patent number: 10156580
    Abstract: A sample processing system that may be automated and methods are disclosed where samples are arranged on a carrier element and a process operation control system automatically processes the samples perhaps robotically with an operationally-influential exteriorly-consequential information monitor or a data capture element. Significant process details as well as operationally-influential exteriorly-consequential information may be monitored and an automatic notice element may cause notification of a person at some display that may be remote. Various people may be notified, such as an administrator, a supplier, or a manufacturer of an opportunity for some action such as reagent reordering or the like. A simulated motion display may be included to “watch” simulated operation in real time or long after completion of the actual processing.
    Type: Grant
    Filed: December 4, 2015
    Date of Patent: December 18, 2018
    Assignee: DAKO DENMARK A/S
    Inventors: Gordon Feingold, Marc Key, John Favuzzi, Rosanne Welcher
  • Patent number: 10078070
    Abstract: An analyzer, and a method and an apparatus for detecting liquid overflowing from a container that the analyzer comprises, are provided. The method according to the present invention for detecting liquid overflowing from a container in the analyzer, includes a step of judging that liquid is overflowing from at least one container if the difference between a standard deviation of absorbance of the liquid measured at a plurality of points of a container at time T1 and a standard deviation of absorbance of the liquid measured at a plurality of points in said container at time T2 is greater than a predetermined threshold value.
    Type: Grant
    Filed: February 17, 2012
    Date of Patent: September 18, 2018
    Assignee: Beckman Coulter, Inc.
    Inventors: Yoshiaki Hashimoto, Noriyoshi Okada
  • Patent number: 10048191
    Abstract: A flow cytometer apparatus and methods for detecting and clearing a clog therein are disclosed. An example method for detecting a clog may include (i) detecting, via a fault detection system of a flow cytometer, a first plurality of events associated with a first aliquot from a first sample well, (ii) determining a count of the first plurality of events associated with the first aliquot, (iii) determining whether the count of the first plurality of events is below a minimum count tolerance and (iv) (a) if the count of the first plurality of events is below the minimum count tolerance, then determining that the flow cytometer has a clog, (b) if the count of the first plurality of events is equal to or above the minimum count tolerance, then detecting a second plurality of events associated with a second aliquot from a second sample well.
    Type: Grant
    Filed: January 20, 2017
    Date of Patent: August 14, 2018
    Assignee: Intellicyt
    Inventor: Aaron B. Kennington
  • Patent number: 10012663
    Abstract: A display unit displays, on a single screen, a first display area configured from a first area corresponding to the position on a reagent disc at which a reagent container is disposed and a second display area configured from a second area corresponding to the position on a reagent loader at which a reagent container is disposed. A control unit changes the display state of the first area on the basis of whether a reagent container is placed at a position on the reagent disk corresponding to the first area and reagent information for the reagent accommodated in the placed reagent container and changes the display state of the second area on the basis of whether a reagent container is placed at a position on the reagent loader corresponding to the second area and reagent-container-conveyance-state information for the placed reagent container.
    Type: Grant
    Filed: April 22, 2015
    Date of Patent: July 3, 2018
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Takaaki Hagiwara, Toshiharu Suzuki, Hiroki Fujita
  • Patent number: 9989544
    Abstract: A technique is disclosed for sample management for use in conjunction with sequencing devices that sequence biological samples, e.g., DNA and RNA. A sequencing device or a network of sequencing devices may be scheduled according to the characteristics of the samples in queue and the capabilities and availability of sequencing devices. Biological samples may be automatically queued and loaded via a sample distribution system. A sample distribution system may be used to reduce operator intervention.
    Type: Grant
    Filed: July 9, 2015
    Date of Patent: June 5, 2018
    Assignee: ILLUMINA, INC.
    Inventors: Robert C. Kain, Alexander G. Dickinson, Min-Jui Richard Shen, Helmy A. Eltoukhy, Francisco Jose Garcia
  • Patent number: 9964553
    Abstract: A blood testing apparatus includes a loader configured to receive a test medium, the test medium including a test object to be tested; a controller configured to perform control to operate the loader to receive the test medium in response to receiving an input of a trigger signal indicating a test start in an emergency mode; a display configured to display a user interface screen indicating the emergency mode; and an analyzer configured to automatically start analysis of the test object under the control of the controller when the test medium is received.
    Type: Grant
    Filed: March 26, 2015
    Date of Patent: May 8, 2018
    Assignee: SAMSUNG ELECTRONICS CO., LTD.
    Inventors: Im-ho Shin, Jong-cheol Kim, Ki-ju Lee, Chung-ung Kim
  • Patent number: 9915673
    Abstract: A tube rack transfer device for transferring racks is presented. A first rail extends in a first horizontal direction and a second rail extends in a second horizontal direction orthogonal to the first direction. The second rail moves along the first rail and comprising a transfer head movable along the second rail. The transfer head comprises a control pin to be coupled with one of: an input pusher, translatable in the second direction, for transferring a rack from a carrier to a sampling area of an analyzer; an output pusher for transferring a rack from the sampling area to a carrier; a rack for transferring the rack between different carriers and/or between different positions of the same carrier. An in-vitro diagnostic instrument comprises an analyzer for carrying out tests on biological samples, a sample unit for inputting/outputting racks, a sampling area for withdrawing samples from tubes, and a transfer device.
    Type: Grant
    Filed: December 5, 2014
    Date of Patent: March 13, 2018
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Marco Bucher, Gottlieb Schacher
  • Patent number: 9914903
    Abstract: An automatic device for inoculating a sample on a substrate with a dilution mechanism formed by a head that holds a stylus in cooperation with a first dilution tank and a second dilution tank to dilute an original sample in at least one sub-sample and for inoculating the sub-sample on a substrate.
    Type: Grant
    Filed: September 13, 2012
    Date of Patent: March 13, 2018
    Assignee: INTERLAB
    Inventor: M. Emmanuel Jalenques
  • Patent number: 9874525
    Abstract: Disclosed herein are methods of producing a test element for studying a body fluid sample. In the methods, a detection layer is covered with a polymeric spreading layer and applied to a support. The spreading layer can be produced by being sprayed onto the detection layer such that the spreading layer has a thickness of at most about 20 ?m. Also disclosed are test elements produced by the methods, as well as tape cassettes incorporating such test elements.
    Type: Grant
    Filed: August 27, 2013
    Date of Patent: January 23, 2018
    Assignee: ROCHE DIABETES CARE, INC.
    Inventors: Joerg Dreibholz, Herbert Fink, Volker Huellen
  • Patent number: 9839086
    Abstract: A method is described for adjusting the brightness of at least one LED according to a changing supply voltage provided to the at least one LED includes acquiring a parameter which indicates the changing supply voltage; and providing, on the basis of the acquired parameter, a control voltage of the at least one LED for adjusting an LED current such that the at least one LED has a predefined relative brightness change over the predefined voltage range. A control unit and an LED lamp which implement the method described here are also discloses. Furthermore, an LED lighting apparatus and a medical diagnostic device having the LED lamp disclosed here are described.
    Type: Grant
    Filed: May 25, 2016
    Date of Patent: December 5, 2017
    Assignee: HEINE OPTOTECHNIK GMBH & CO KG
    Inventors: Norbert Merkt, Benjamin Komm, Manfred Wittlinger, Oliver Heine, Bernd Kabbeck
  • Patent number: 9784754
    Abstract: An automatic analyzer achieves both restraining unnecessary usage of a consumable supply and reducing burdens on an operator in a re-execution processing in a case where pipe functions are suspended/stopped, and is capable of completely efficiently performing an analysis preparation processing or an analysis terminating processing.
    Type: Grant
    Filed: November 11, 2013
    Date of Patent: October 10, 2017
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Osamu Matsumoto, Teruhiro Yamano
  • Patent number: 9581584
    Abstract: A diluted cleaning solution is contacted with the inner wall surface of an immunity measuring cell every time an immunity measurement treatment of a specimen is performed. Therefore, a diluting liquid is injected in advance, then a cleaning solution is injected, whereby a diluted cleaning solution is produced in the immunity measuring cell. As a result, the inner wall surface of the immunity measuring cell is maintained in a preferable state and the interval of the routine cleanings can be prolonged.
    Type: Grant
    Filed: May 15, 2014
    Date of Patent: February 28, 2017
    Assignee: HORIBA, Ltd.
    Inventor: Kazumasa Takemoto
  • Patent number: 9527085
    Abstract: The invention relates generally to the field of automated collection and deposition of fluid, semi-solid, and solid samples of biological or chemical materials. More specifically, the invention relates to the field of microarrayers, which are devices for autonomously depositing minute droplets of biological or chemical fluid samples in ordered arrays onto substrates. The invention also relates to tissue arrayers, which are devices for the collection and deposition of solid and semi-solid tissue samples in ordered arrays. Other aspects of the invention relate to fluidics robots, which are devices for the autonomous collection, dispensing and processing of biological or chemical fluid samples. The invention improves the throughput of microarrayers, tissue arrayers, and fluidics robots by providing methods and apparatuses to precisely and repeatably load supplies into the machines.
    Type: Grant
    Filed: August 5, 2009
    Date of Patent: December 27, 2016
    Assignee: Aushon Biosystems, Inc.
    Inventors: John Austin, Peter D. Honkanen
  • Patent number: 9522205
    Abstract: In a low temperature hydrogen peroxide gas plasma sterilizer, the accurate control of concentration of the hydrogen peroxide sterilant is an important factor in determining reliability and sterilization efficacy of the sterilization process. The present application describes sterilizers, and sterilization methods, which use a novel injector-concentrator arrangement which allows accurate concentration of the sterilant performed concurrently with the sterilization process. This process enables the device to sterilize wide range of sensitive equipment within a shorter sterilization cycle.
    Type: Grant
    Filed: August 1, 2013
    Date of Patent: December 20, 2016
    Assignee: GETINGE STERICOOL MEKICAL ALTETLER SAN. VE TIC. A.S.
    Inventor: Fatih Ahiska
  • Patent number: 9464970
    Abstract: The invention relates inter alia to an automated stainer for staining, in particular for hemalum-eosin (HE) staining, of a histological sample, the automated stainer exposing the sample to the action of at least one stain using at least one staining parameter. The automated stainer is notable for the fact that the automated stainer comprises an input means with which a staining parameter is definable, in particular is inputtable or is selectable from a plurality of possible staining parameters; and that a control apparatus is present which, upon application of the defined staining parameter, ascertains the prospectively expectable outcome of an action and displays it to the user with a display apparatus, before the automated stainer actually stains the sample.
    Type: Grant
    Filed: September 10, 2013
    Date of Patent: October 11, 2016
    Assignee: Leica Biosystems Nussloch GmbH
    Inventor: Markus Berberich
  • Patent number: 9417253
    Abstract: A specimen processing system comprising: a specimen measuring section for measuring specimens accommodated in specimen containers; a transport section for transporting specimen containers to the specimen measuring section; a specimen container collect section for collecting specimen containers; an obtainer for obtaining shape information on specimen containers or state information on specimens accommodated in specimen containers; a supply judger configured for determining whether specimen containers are to be supplied to the specimen measuring section on the basis of the result obtained by the obtainer; and a delivery section for delivering specimen containers, which are determined to be supplied to the specimen measuring section by the supply judger, toward the transport section, and delivering specimen containers, which are determined not to be supplied to the specimen measuring section by the supply judger, toward the specimen container collect section, is disclosed.
    Type: Grant
    Filed: October 28, 2009
    Date of Patent: August 16, 2016
    Assignee: SYSMEX CORPORATION
    Inventors: Yasuo Yonekura, Yuichiro Ohmae, Tokihiro Kosaka, Takaaki Nagai
  • Patent number: 9329193
    Abstract: A sample processing apparatus for performing a process including a plurality of steps on a sample, the sample processing apparatus sequentially processing a plurality of samples, is disclosed. The apparatus comprises a plurality of units corresponding to the respective steps in the process; a transfer section which transfers a sample to the units according to a flow of the steps; and a controller. Specifically, when an operation was not performed successfully, the controller interrupts the process for a sample that had not reached the location where the unsuccessful operation was performed while continuing the process for a sample that had already passed the location, retries the operation that was not performed successfully, and resumes the interrupted process when the retried operation has been performed successfully.
    Type: Grant
    Filed: September 12, 2011
    Date of Patent: May 3, 2016
    Assignee: SYSMEX CORPORATION
    Inventors: Hiromi Onomichi, Mitsuo Yamasaki
  • Patent number: 9316658
    Abstract: A sample processing apparatus comprising: a plurality of testing units arranged along a transport path and each configured to perform at least one type of test; a plurality of transport units configured to collectively constitute the transport path and collectively function to deliver samples to the plurality of testing units for testing; and at least one processor of a computer system and at least one memory that stores programs executable by the at least one processor to: (a) determine a type of test required to be performed on a sample; (b) if a trouble of a transport unit is reported, determine whether there is an available testing unit performable of the required type of test to which the sample is deliverable; (c) if there is the available testing unit, instruct to transport the sample to the available testing unit.
    Type: Grant
    Filed: March 28, 2011
    Date of Patent: April 19, 2016
    Assignee: SYSMEX CORPORATION
    Inventor: Hiroo Tatsutani
  • Patent number: 9285380
    Abstract: The invention relates to a measurement system MS1 provided with a plurality of loading units 10 into which a measurement tool 4 supporting a reagent is loaded. The measurement system MS1 includes reading means 2 for reading information on an analyte provider that includes identification information, and guidance means 11 for guiding the measurement tool 4 to which an analyte derived from the analyte provider has been or is to be applied, to a loading unit that is selected from the plurality of loading units 10 and individually associated with the analyte provider based on the identification information that has been read by the reading means 2. With such configuration, the measurement results obtained from the analyte derived from the analyte provider can be easily associated with the information on the analyte provider that includes the identification information.
    Type: Grant
    Filed: November 22, 2010
    Date of Patent: March 15, 2016
    Assignee: ARKRAY, Inc.
    Inventors: Tokuo Kasai, Takashi Nakagawa, Minoru Kotaki
  • Patent number: 9255937
    Abstract: Provided is an automatic analyzer that includes a suction nozzle, a detection container, and a detector. The suction nozzle suctions a sample and a solution used for the detection of the sample. The suctioned sample and the solution are supplied to the detection container. The detector detects a signal from the sample. In addition, a vessel for the sample and a container for the solution are disposed below the detection container.
    Type: Grant
    Filed: July 20, 2011
    Date of Patent: February 9, 2016
    Assignee: HITACHI HIGH TECHNOLOGIES CORPORATION
    Inventors: Yukinori Sakashita, Katsuaki Takahashi, Yoshihiro Yamashita, Taku Sakazume
  • Patent number: 9248474
    Abstract: A generation device and the like for generating long-life antibody chips which can be produced and held in stock is a generation device and the like for generating an antibody chip by binding antibody to a cup, including an antibody solution holder that holds antibody solution having antibody, a buffer solution holder that holds buffer solution, and an injector that injects solution into the cup. The injector has an inlet out of which solution is injected. The injector injects the buffer solution held by the buffer solution holder. The injector injects the antibody solution held by the antibody solution holder with the inlet in the buffer solution in the cup.
    Type: Grant
    Filed: June 10, 2011
    Date of Patent: February 2, 2016
    Assignee: Ushio Denki Kabushiki Kaisha
    Inventors: Youichi Teramoto, Kazuhira Sakamoto, Toshikazu Kawaguchi
  • Patent number: 9244086
    Abstract: A sample analyzing system comprising: a first sample analyzer including a first measurement unit for measuring a sample and a first control unit for controlling the first measurement unit; and a second sample analyzer including a second measurement unit for measuring the sample and a second control unit for controlling the second measurement unit; wherein the first control unit is configured to transmit an activation signal for activating the second sample analyzer when a predetermined condition is met for the first sample analyzer; and the second control unit is configured to activate the second sample analyzer when the activation signal is received.
    Type: Grant
    Filed: March 27, 2013
    Date of Patent: January 26, 2016
    Assignee: SYSMEX CORPORATION
    Inventors: Syunsuke Yao, Shiro Kuwaoka, Taisuke Nishida
  • Patent number: 9229015
    Abstract: There is provided a comprehensive accuracy management method attained by including the steps of: displaying operation event information in time series in an accuracy management result chart or a calibration result chart on the same screen; accumulating a characteristic daily measurement value fluctuation pattern on the basis of a kind of an operation event; displaying the latest fluctuation pattern of measurement results and the daily measurement value fluctuation pattern in superposition with each other to warn of fluctuations which differ from the daily measurement value fluctuation pattern; and estimating and reporting the cause of the fluctuations.
    Type: Grant
    Filed: November 19, 2009
    Date of Patent: January 5, 2016
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Qing Li, Tomonori Mimura, Shinichi Fukuzono, Naomi Ishii
  • Patent number: 9213037
    Abstract: Disclosed is a sample analyzer including a transporting part configured to transport a sample rack holding one or more samples, a measuring part configured to perform a measurement on the sample of the transported sample rack and a controller. The controller is programmed to perform an analysis of a predetermined item that requires at least first and second measurement results derived respectively from first and second samples obtained from the same subject and preprocessed in different ways, and if a measurement of the predetermined item is requested and a set of first and second samples obtained from the same subject and preprocessed in different ways are transported to the measuring part, the controller controls the measuring part to perform measurements on both of the first and second samples to derive the first and second measurement results and processes them to generate an analysis result of the predetermined item.
    Type: Grant
    Filed: September 26, 2013
    Date of Patent: December 15, 2015
    Assignee: SYSMEX CORPORATION
    Inventors: Hiroshi Kurono, Yasuhiro Takeuchi
  • Patent number: 9198623
    Abstract: Analyte monitoring devices, systems, and methods are provided that relate to: enabling different application features on a data processing device for analyte monitoring devices with different analyte monitoring features; programming analyte monitoring devices in advance; personalizing an analyte monitoring device; graphically representing a remaining insulin level in a user body; and graphically representing analyte measurement related data for on-demand readings; protecting access to feature of an analyte monitoring device.
    Type: Grant
    Filed: April 21, 2011
    Date of Patent: December 1, 2015
    Assignee: Abbott Diabetes Care Inc.
    Inventors: Jonathan Fern, Mark P. Jesser, Lynn Dixon, Jai Karan, Charles Wei, Matthew T. Vogel, Tim S. Gasperak, Kim Cullen, Kim Ladin, Marc B. Taub, Gary A. Hayter
  • Patent number: 9164021
    Abstract: A reagent preparing device capable of supplying a mixed solution, including a first liquid and a second liquid, to a measurement section for measuring a specimen using the mixed solution as a reagent, the reagent preparing device comprising: a first mixed solution container for accommodating the mixed solution; a second mixed solution container for accommodating the mixed solution; and a controller for controlling supply of the first liquid and the second liquid to supply the first liquid and the second liquid to the first mixed solution container, and to supply the first liquid and the second liquid to the second mixed solution container, is disclosed. A specimen processing system, and a reagent preparing method are also disclosed.
    Type: Grant
    Filed: February 24, 2010
    Date of Patent: October 20, 2015
    Assignee: SYSMEX CORPORATION
    Inventors: Koichi Okubo, Noriyuki Nakanishi, Masahiko Oguro, Tomoyuki Asahara
  • Patent number: 9121839
    Abstract: An analyzing system that enables further expansion of analysis items and automation of analysis. In the analyzing system for performing an analysis using container 1 and an analyzing apparatus, container 1 is a dedicated container previously containing a reagent for a specific analysis item or an expansion container to which a user can freely set an analysis item.
    Type: Grant
    Filed: January 21, 2010
    Date of Patent: September 1, 2015
    Assignee: ARKRAY, Inc.
    Inventors: Mitsuharu Hirai, Satoshi Majima, Toshiya Hosomi
  • Patent number: 9091670
    Abstract: There is provided a method of cleaning a dispensing assembly for small liquid droplets less than 50 ?l and even as low as 10 nl. A purging step with pressurized gas followed by a cleaning step using a suitable cleaning liquid is carried out a number of times.
    Type: Grant
    Filed: February 1, 2011
    Date of Patent: July 28, 2015
    Assignee: Allegro Research Limited
    Inventors: Igor Shvets, Cecilia Franken, Aoife Gallagher, Jeurgen Osing
  • Patent number: 9079178
    Abstract: Pipette tips of different sizes may be coupled to a pipettor without needing to modify the pipettor. The same pipettor may thus be utilized to exchange different pipette tips, which may be done in an automated manner. Pipette tips may be coupled to adaptors that include proximal ends for interfacing with the pipettor and distal ends for interfacing with pipette tips. The proximal ends may all have the same geometry, matched with the same pipettor. The distal ends may have different geometries matched with different pipette tips. A pipettor may be part of a liquid handling apparatus and movable in an automated manner to different deck positions. The pipettor may include a locking mechanism for locking adaptors to the pipettor or locking pipette tips directly to the pipettors, and an ejection mechanism for ejecting pipette tips from corresponding adaptors.
    Type: Grant
    Filed: February 6, 2013
    Date of Patent: July 14, 2015
    Assignee: Agilent Technologies, Inc.
    Inventor: Brian M. Sheldon
  • Publication number: 20150147230
    Abstract: A configuration of detecting light from the front face of a light source is the best for confirming the variation of a light quantity, but when a plurality of light sources are present, as many detectors for checking a light quantity as the light sources are necessary and the apparatus configuration becomes complex. In the present invention, a detector for checking a light source light quantity is installed in a reaction container transfer mechanism used commonly for a plurality of detection sections, and the light quantities of light sources are checked with the detector.
    Type: Application
    Filed: May 24, 2013
    Publication date: May 28, 2015
    Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION
    Inventors: Keiko Yoshikawa, Akihisa Makino
  • Patent number: 9040303
    Abstract: An apparatus for measuring a volume of fluid includes at least one emitter configured to project a signal toward a predetermined position of a sample container, at least one receiver configured to receive the signal after the signal interacts with the sample container and a fluid transfer device in communication with the receiver and sample container. A change in the signal received by the receiver indicates when the fluid has dropped below the predetermined position. The apparatus determines a volume of fluid that the fluid transfer device has removed from the sample container when the receiver detects that the fluid has dropped below the predetermined position.
    Type: Grant
    Filed: March 18, 2013
    Date of Patent: May 26, 2015
    Assignee: Argos Therapeutics, Inc.
    Inventors: Simon Jonathon Spence, Richard Alexander Grant
  • Patent number: 9039971
    Abstract: Provided in part are processes for manufacturing pipette tip trays that improve quality assessment of the pipette tips therein.
    Type: Grant
    Filed: August 10, 2012
    Date of Patent: May 26, 2015
    Assignee: Biotix, Inc
    Inventor: Arta Motadel
  • Patent number: 9040304
    Abstract: A multi-channel system and methods for sorting particles according to one or more characteristics of the particles. The system includes multiple flow cytometry units, each unit can have a nozzle for producing a fluid stream containing a desired population of particles in a mixture of particles. Each of the units may be operable to sort said desired population of particles by interrogating the fluid stream with a beam of electromagnetic radiation and classifying particles based on one or more characteristics of the particles. The system also includes a common fluid delivery system for delivering sheath fluid to each flow cytometer unit for producing respective fluid streams.
    Type: Grant
    Filed: March 12, 2014
    Date of Patent: May 26, 2015
    Assignee: Inguran, LLC
    Inventors: Gary Durack, Jeffrey D. Wallace, Gary P. Vandre, Lon A. Westfall, Jeremy T. Hatcher, Niraj V. Nayak
  • Publication number: 20150140668
    Abstract: An automation system for an in vitro diagnostics environment includes a plurality of intelligent carriers that include onboard processing and navigation capabilities. The intelligent carriers can include one or more image sensors to observe the relative motion of the track as the carrier traverses it. The carriers can also observe position marks on the track surface to provide absolute position information, which can include additional data, such as routing instructions. Synchronization marks may be provided to correct errors in the observed trajectory.
    Type: Application
    Filed: May 21, 2013
    Publication date: May 21, 2015
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: Colin Mellars, Baris Yagci, Benjamin Samuel Pollack
  • Publication number: 20150140669
    Abstract: A cartridge for dispensing fluid is presented. The cartridge comprises a valve. The valve comprises a pumping chamber for pumping the fluid. The valve positions a pumping chamber conduit. The pumping chamber conduit is connected to the pumping chamber. The cartridge further comprises a plunger for changing the volume of the pumping chamber. The cartridge further comprises a reservoir conduit for connecting the reservoir with the valve. The valve positions the pumping chamber conduit to connect with the reservoir conduit. The cartridge further comprises an outlet conduit for dispensing the fluid. The valve further rotates the pumping chamber conduit to connect with the outlet conduit.
    Type: Application
    Filed: November 3, 2014
    Publication date: May 21, 2015
    Inventors: Christoph Boehm, Peter Kupser, Norbert Oranth, Juergen Spinke, Thursten Brueckner, Timo Klein
  • Patent number: 9034278
    Abstract: A sample is cleaned up for spectroscopic analysis by receiving a slide substrate having the sample thereon, fixing the sample to a substrate surface of the slide substrate by applying heat to the slide substrate for a predetermined heating time and incubating the sample on the slide substrate for a predetermined incubation time after fixing the sample to the slide substrate. The sample is further cleaned by washing the sample on the slide substrate after the sample has been incubated and drying the sample by applying heat to the slide substrate for a predetermined drying time, wherein the sample on the slide substrate after drying has retained particles of interest and interferant particles are removed from the substrate. A substrate is also provided for sample collection, which is culturable and Raman silent.
    Type: Grant
    Filed: August 29, 2012
    Date of Patent: May 19, 2015
    Assignee: Battelle Memorial Institute
    Inventors: Andrew P. Bartko, Johnway Gao
  • Patent number: 9028778
    Abstract: The present disclosure provides methods for carrying out Romanowsky-type stains, specifically Wright-Giemsa and May-Grünwald stains, quickly and efficiently. The methods greatly reduce the overall amount of time required to complete a Wright-Giemsa stain or a May-Grünwald stain of sufficient quality on a biological sample. The subject methods can be applied to both manual and automated staining procedures.
    Type: Grant
    Filed: December 21, 2012
    Date of Patent: May 12, 2015
    Assignee: Abbott Laboratories
    Inventors: Abe S. Mamaghani, Koshy T. Chacko, Rupa Rao, Rene Nieves
  • Patent number: 9028756
    Abstract: A specimen analyzing method and a specimen analyzing apparatus capable of measuring interference substances before analyzing a specimen. The method comprises a step for sucking the specimen stored in a specimen container (150) and sampling it in a first container (153), a step for optically measuring the specimen in the first container, a step for sampling the specimen in a second container (154) and preparing a specimen for measurement by mixing the specimen with a reagent in the second container, and a step for analyzing the specimen for measurement according to the results of the optical measurement of the specimen.
    Type: Grant
    Filed: August 30, 2013
    Date of Patent: May 12, 2015
    Assignee: Sysmex Corporation
    Inventors: Norimasa Yamamoto, Takashi Yamato, Naohiko Matsuo, Satoshi Iguchi
  • Publication number: 20150125961
    Abstract: The invention relates to an access control device for a laboratory instrument serving for the instrument-controlled treatment of a laboratory sample and this laboratory instrument, and also to a method for controlling the access to functions of the laboratory instrument by means of the access control device, wherein the access control device comprises: a first interface apparatus and a second interface apparatus; and a control apparatus wherein the control apparatus is configured: a) to establish one or more first data connections to one or more user interface apparatuses via the first interface apparatus; b) to establish a second data connection to the laboratory instrument via the second interface apparatus; and c) to control authorizations and/or access permissions for user access to functions of the laboratory instrument via the first and second data connections.
    Type: Application
    Filed: October 7, 2014
    Publication date: May 7, 2015
    Inventors: Wolfgang GOEMANN-THOSS, Wolf WENTE, Andreas THIEME, Jan-Gerd FRERICHS, Christiane MARKAU, Jan-Hendrik HACKER