With Specific Analytical Program Control Means Patents (Class 422/67)
  • Patent number: 8277729
    Abstract: The present invention is to present a sample analyzer which is capable of respond immediately when a need to perform analysis of multiple items arises. The sample analyzer 1 includes a table 12 capable of holding a first rack 320 and a second rack 330; a reagent dispensing arm 120 which comprises a pipette part 121; a reagent dispensing driving section 120a for moving the reagent dispensing arm 120; a reagent barcode reader 350; and a control section 501 for controlling the reagent dispensing driving section 120a so as to move the pipette part 121 to a predetermined reagent aspirating position according to the identification information obtained by the reagent barcode reader 350.
    Type: Grant
    Filed: March 27, 2008
    Date of Patent: October 2, 2012
    Assignee: Sysmex Corporation
    Inventors: Naohiko Matsuo, Hiroyuki Fujino, Takamichi Naito, Nobuhiro Kitagawa
  • Patent number: 8278108
    Abstract: An automatic analyzer of the type equipped with a sample preprocessing function pretreats a desired sample in a pretreating unit before pipetting the sample into an analyzing unit for analysis. When all samples are carried to the analyzing unit via the pretreating unit, irrespective of whether the sample is to be pretreated, this causes loss in terms of both costs and installation space requirements. In the case where the preprocessing is required, a minimal quantity of the sample is also necessary in order to make the sample react to the preprocessing liquid. In addition, the possible presence of a residual sample left in the pretreating unit could affect analytical results. The automatic analyzer which includes an analyzing unit and a pretreating unit further includes a sample-pipetting mechanism constructed to have a function that allows the mechanism to access a plurality of pipetting positions without a sample sucking/discharging position being fixed.
    Type: Grant
    Filed: January 22, 2010
    Date of Patent: October 2, 2012
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Kentaro Wada, Katsuhiro Kambara, Tetsuji Kawahara, Hidenobu Komatsu
  • Patent number: 8277752
    Abstract: An optical measurement apparatus is provided for conducting a test by efficiently reading color development of a reagent after reaction by optical measurement. To the above end, an optical measurement apparatus is provided which is to be used with at least one test instrument mounted to the apparatus. The test instrument includes a carrier provided with at least one reagent retaining portion which retains a reagent, and a sample is applied to the carrier. The optical measurement apparatus includes a reader for reading color development of the reagent retaining portion, and a controller for performing driving control of the reader and determination. The controller performs the determination by utilizing data obtained by a reading operation P to read the color development of the reagent performed after the lapse of a reaction completion period Tr1-Tr6 from the mounting of the test instrument, and the reaction completion period depends on the reagent.
    Type: Grant
    Filed: November 20, 2008
    Date of Patent: October 2, 2012
    Assignee: ARKRAY, Inc.
    Inventors: Takashi Nakagawa, Shinya Nakajima, Tokuo Kasai, Kazuhiro Ohmiya
  • Patent number: 8277730
    Abstract: A tissue infiltration apparatus (1) for specimens present in cassettes (5) comprises at least two liquid containers (7, 11, 13, 15) and a transport apparatus (6). Multiple cassettes (5) are receivable in a transport basket (4). The transport apparatus (6) is configured in such a way that at least two transport baskets (4) are transportable in the tissue infiltration apparatus (1). A transport basket (4) is deliverable to, and/or movable away from, a liquid container (7, 11, 13, 15) with the transport apparatus (6). An execution sequence (21) in which the transport baskets (4) pass through the liquid containers (7, 11, 13, 15) is definable. To enable accelerated or preferred processing of a transport basket (4) with the tissue infiltration apparatus (1), at least one means (8) is provided with which the order of two transport baskets (4) is definably modifiable.
    Type: Grant
    Filed: October 12, 2011
    Date of Patent: October 2, 2012
    Assignee: Leica Biosystems Nussloch GmbH
    Inventors: Hermann Ulbrich, Karl-Heinz Westerhoff, Stefan Künkel, Janet Minshew
  • Patent number: 8268241
    Abstract: A process wherein outgassing rates of volatile organic compounds (VOCs) in an object, particularly habitable vehicles, are accelerated by placing the subject object in a vacuum chamber and placing heat sources either inside the object being treated, outside the object, or both. The process includes measuring and monitoring the temperature of selected surfaces inside the object being treated. The heat sources are adjusted to maintain a temperature which is safe for the materials and which will promote maximum outgassing rates. During the treatment process, while a vacuum and heat are being applied to the subject object, the gasses in the chamber are monitored for both their composition and quantity. When the outgassing rates of the VOCs reach acceptable levels, the process cycle is terminated. The vacuum in the chamber is broken to restore atmospheric pressure, and the object being treated is removed from the chamber.
    Type: Grant
    Filed: October 14, 2008
    Date of Patent: September 18, 2012
    Inventor: Henry W. Cooper
  • Patent number: 8262990
    Abstract: The fluidic system with an unclogging feature of the preferred embodiment includes a flow channel, a sheath pump to pump sheath fluid from a sheath container into an interrogation zone, and a waste pump to pump waste fluid from the interrogation zone into a waste container. The sheath pump and/or the waste pump draw sample fluid from a sample container into the interrogation zone. The fluidic system also includes a controller to adjust the flow rate of the sample fluid from the sample container into the interrogation zone. The pump and controller cooperate to propagate a pulsation through the flow channel from the pump if the flow channel is clogged. The fluidic system is preferably incorporated into a flow cytometer with a flow cell that includes the interrogation zone.
    Type: Grant
    Filed: August 16, 2010
    Date of Patent: September 11, 2012
    Assignee: Accuri Cytometers, Inc.
    Inventors: Nathaniel C. Bair, Collin A. Rich
  • Patent number: 8262999
    Abstract: Tempering of sample (58) in test strip (37) is carried out by temperature regulating unit (40) and heating/cooling unit (92). The sample is fed to the test strip by a developer fluid (57) and a metering unit (55). The result of the detection reaction becomes visible by a change in color (36), which is detected optically and analyzed. The data of a control chart (52) with the measured values of first and second temperature sensors (41, 42) are used to set the control parameters for tempering. Code (86) on the test sample holder (35) is read in a sequence of steps. Parameters for phases of the measurement are determined from measured values of first and second temperature sensors, values of the control chart and the code of the test sample holder. These parameters are used by the temperature regulating unit during the measurement.
    Type: Grant
    Filed: February 23, 2009
    Date of Patent: September 11, 2012
    Assignee: Dräger Safety AG & Co. KGaA
    Inventors: Ingo Kaneblei, Thomas Wuske, Rainer Polzius, Björn Lange
  • Patent number: 8262991
    Abstract: The present invention relates generally to an apparatus for analysing fluid taken from a body, and more in particularly for analysing body fluids from mammals. The analysis apparatus is coupled to a dairy system for milking of cows, wherein it may be useful to analyse the status of the milk. The apparatus is preferably located as early as possible in the production chain in order to obtain results as close as possible to the cows. Hence the environment in which the apparatus is to be used may be harsh towards internal apparatus modules or consumables, therefore the apparatus is isolated and the internal environment is conditioned regarding humidity, temperature as well as the amount of ammonium. Furthermore the steps for analysing milk is automated inside the apparatus in order to avoid influence from the external environment.
    Type: Grant
    Filed: May 19, 2004
    Date of Patent: September 11, 2012
    Assignee: Lattec I/S
    Inventors: Thomas Nikolai Carlsen, Peter Christiansen, Kristjan Freyr Gudmundsson, Frederik Nikolaj Svaerke Sonnenborg
  • Patent number: 8252235
    Abstract: A liquid sample is aspirated using an aspirating tube provided with a flow path extending lengthwise in the interior of the tube, and an aspiration orifice for aspirating the liquid sample formed near the tip of the tube. The aspiration of the liquid sample to the aspirating tube is monitored during aspiration. Liquid sample is aspirated by the aspirating tube, and the collected material in the aspirating tube in the region at the tip side from the region containing the liquid sample to be used for measurement is delivered to a detecting part provided externally to the aspirating tube, and whether or not liquid sample is contained in the collected material is detected in the detecting part.
    Type: Grant
    Filed: August 28, 2006
    Date of Patent: August 28, 2012
    Assignee: Sysmex Corporation
    Inventors: Masaharu Shibata, Yoichi Nakamura
  • Patent number: 8252233
    Abstract: A sample-processing system that improves total system processing efficiency, and reduces a sample-processing time, by establishing a functionally independent relationship between a rack conveyance block with rack supply, conveyance, and recovery functions, and a processing block with sample preprocessing, analysis, and other functions. A buffer unit with random accessibility to multiple racks standing by for processing is combined with each of multiple processing units to form a pair, and the system is constructed to load and unload racks into and from the buffer unit through the rack conveyance block so that one unprocessed rack is loaded into the buffer unit and then upon completion of process steps up to automatic retesting, unloaded from the buffer unit. Functional dependence between any processing unit and a conveyance unit is thus eliminated.
    Type: Grant
    Filed: December 23, 2008
    Date of Patent: August 28, 2012
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Hitoshi Tokieda, Yoshimitsu Takagi, Takeshi Shibuya, Masashi Akutsu
  • Patent number: 8252234
    Abstract: An apparatus is provided for producing pharmaceutical and pharmaceutical-like product. The apparatus provides real-time monitoring of the pharmaceutical product and can provide real-time control. The apparatus monitors the dosage both before and after it has been added to a carrier substrate. The apparatus can provide monitoring of each pharmaceutical product that is processed.
    Type: Grant
    Filed: June 9, 2005
    Date of Patent: August 28, 2012
    Assignee: SmithKline Beecham Corporation
    Inventors: Allan J. Clarke, David George Doughty, Frederick H. Fiesser, David S. Wagner
  • Patent number: 8246907
    Abstract: An automatic analyzer and an automatic analyzing system to identify samples and reagents used in the analyzer and members used in measurement of at least two objects in common: system reagents or buffer solution; sensor parts; probes; nozzles; chips; dispensing cups; tubes; ISE electrodes; detectors; deionized water; and waste, and to unify management of identification information thereof and a measurement result.
    Type: Grant
    Filed: September 1, 2006
    Date of Patent: August 21, 2012
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Noriko Maeda, Kyoko Imai, Taku Sakazume, Yukie Tokiwa, Kantaro Suzuki
  • Patent number: 8241914
    Abstract: A method and apparatus for sorting stained particles in a fluid stream, each of the method and apparatus including an epi-illumination optics system with a focusing lens. The optics system being operable to direct a beam of electromagnetic radiation through the focusing lens in a forward direction along a beam axis intersecting particles in the fluid stream at the first location so that the particles pass through the beam, resulting in the fluorescence emissions from the particles being directed along the beam axis in a rearward direction.
    Type: Grant
    Filed: May 12, 2011
    Date of Patent: August 14, 2012
    Assignee: Inguran LLC
    Inventors: Gary Durack, Jeffrey D. Wallace, Gary P. Vandre, Lon A. Westfall, Jeremy T. Hatcher, Niraj V. Nayak
  • Patent number: 8234941
    Abstract: A specimen analyzing apparatus comprising: a detector for detecting component information regarding a component in a specimen contained in each of analyzing containers, the analyzing containers comprising first and second analyzing containers; an analyzing part for analyzing the component information detected by the detector; a transporting device for transporting specimen containers each containing a specimen, the specimen containers comprising first and second specimen containers; an operation mode selector for selecting one of a first operation mode and a second operation mode; a first supplying device for supplying the specimen of a first amount; a second supplying device for supplying the specimen of a second amount grater than the first amount; and a supply controller for controlling the first and second supplying devices in accordance with an operation mode selected by the operation mode selector, is disclosed. A specimen analyzing method is also disclosed.
    Type: Grant
    Filed: October 28, 2009
    Date of Patent: August 7, 2012
    Assignee: Sysmex Corporation
    Inventors: Kazuya Fukuda, Hiroki Koike, Hironori Katsumi, Takashi Yamato, Masayuki Ikeda, Tsuyoshi Fukuzaki, Daisuke Nakano, Masanori Imazu, Nobuhiro Kitagawa
  • Patent number: 8236255
    Abstract: An apparatus for treating slides has a base with a cavity, and a heater is located on a surface of the cavity. A tank, which supports a slide rack with the slides submerged in a slide treatment solution, is placed in the cavity with a tank surface immediately adjacent the heater. A temperature sensor is mounted in the base and is operable to provide a feedback signal representing a temperature of the liquid in the tank. A cover is removably hinged on the base to cover the tank. A control system is connected to the heater and the temperature sensor and has a user input/output that is operable to select a set temperature of the liquid and a cycle time.
    Type: Grant
    Filed: December 2, 2004
    Date of Patent: August 7, 2012
    Assignee: Lab Vision Corporation
    Inventors: Glenn K. Takayama, Ken K. Tseung, Norman K. Rhett, Wai Bun Wong, Samuel Burd, George A. Harter, Douglas C. Morrison
  • Publication number: 20120195795
    Abstract: The invention relates to a method for continuously determining the concentration of at least one CN compound in an aqueous solution, wherein a carrier gas, for example compressed air, is introduced into the aqueous solution and the introduced carrier gas is fed at least partially to a gas analyzer, for example an HCN gas analyzer, the analysis data of which are considered in the determination of the concentration of the CN compound in the aqueous solution. In order to create advantageous method conditions, the temperature of the aqueous solution exposed to carrier gas is considered in the determination of the concentration of the CN compound.
    Type: Application
    Filed: August 3, 2010
    Publication date: August 2, 2012
    Applicant: VOESTALPINE STAHL GMBH
    Inventors: Franz Parzermair, Leopold Moser, Manfred Naderer
  • Publication number: 20120196374
    Abstract: A dispenser, analyzer and dispensing method are provided, which can dispense a predetermined amount of a blood cell sample without being influenced by an individual difference of the blood cell sample. The apparatus according to the present invention includes: a pressure sensor measuring pressure within a pipe during liquid suction by a dispensing probe, a calculation section calculating an average pressure value during liquid suction, measured by the pressure sensor; a storage section storing a correlation between the average pressure value and a discharge operation amount during liquid suction for each desired discharge amount; a correction section correcting the discharge operation amount based on the average pressure amount during suction calculated by the calculation section and the correlation stored in the storage section; and a control section controlling a syringe pump based on the discharge operation amount corrected by the correction section to discharge the desired discharge amount.
    Type: Application
    Filed: April 9, 2012
    Publication date: August 2, 2012
    Applicant: Beckman Coulter, Inc.
    Inventor: Tadashi Haga
  • Patent number: 8231830
    Abstract: A sample analyzer: measures a measurement sample including a sample and a reagent; creates a calibration curve based on first measurement data obtained by measuring a measurement standard sample including a standard sample and the reagent; provides calibration curve specifying information for specifying the calibration curve to the calibration curve; acquires an analysis result by processing second measurement data obtained by measuring the measurement sample based on the calibration curve; and stores the analysis result and the calibration curve specifying information provided to the calibration curve used in the process of the second measurement data in correspondence to each other.
    Type: Grant
    Filed: March 18, 2008
    Date of Patent: July 31, 2012
    Assignee: Sysmex Corporation
    Inventors: Yuji Wakamiya, Tomohiro Okuzaki, Hisato Takehara
  • Patent number: 8226536
    Abstract: High-throughput centrifugation of batches of samples is achieved by dividing a single centrifugation run of a batch of samples into two or more staggered, discrete spins with fewer samples and in which the availability of centrifuge slots for loading or unloading of samples and the subsequent delivery of experimental results can be enhanced. The methodology is particularly useful in situations where multiple samples need to be processed rapidly, for example, as part of a STAT blood typing program in urgent care facilities prior to blood transfusion.
    Type: Grant
    Filed: December 12, 2011
    Date of Patent: July 24, 2012
    Assignee: Ortho-Clinical Diagnostics, Inc.
    Inventors: Michael L. Dee, Donald J. Moran, Jr., Mark Sawczuk, William G. Atterbury, Michael L. Marshall, Douglas E. Boyd
  • Patent number: 8221684
    Abstract: A mobile intra-operative microscopic diagnosis laboratory capable of analyzing fresh tissue specimens and providing intra-operative consultation within 20 minutes is described. The mobile laboratory is preferably a van and contains a cryostat for freezing the fresh tissue specimens and a means for cutting the specimens. In addition, it also contains the means for reading the slides to make microscopic diagnosis and a means for handling for fresh tissue and a means for indicating various locations in the specimen, preferably by inking them. It preferably contains a stainer for staining the samples and an intercom for communicating the microscopic diagnosis back to the operating room.
    Type: Grant
    Filed: August 15, 2008
    Date of Patent: July 17, 2012
    Inventor: V. Raman Sukumar
  • Publication number: 20120177536
    Abstract: Ion concentration measurement requires a calibration before the start of the measurement, and thus the start of the measurement is delayed for the calibration period. Hence, the calibration is made unnecessary by reading an electrode slope value specific to an ion selective electrode for measuring the concentration of particular ions dissolved in a test solution, from an information presenting unit of an ion selective electrode cartridge including the ion selective electrode.
    Type: Application
    Filed: September 17, 2010
    Publication date: July 12, 2012
    Inventors: Chiki Sakai, Osamu Nozawa, Hiroshi Mitsumaki
  • Patent number: 8216512
    Abstract: The present invention concerns an apparatus for automatic processing at least one biological sample accommodated on a carrier member, such as a slide by applying a predetermined amount of reagents in a predetermined sequence according to a processing protocol, said apparatus comprising; a housing frame; at least one processing section for accommodating at least one slide, the at least one processing section is provided within the housing; a hood cover protecting the at least one processing section in said housing; wherein the hood cover completely encloses the processing section defining an interior space; and wherein the apparatus further comprises climate control device provided to control the environment within the interior space.
    Type: Grant
    Filed: December 19, 2003
    Date of Patent: July 10, 2012
    Assignee: DAKO Denmark A/S
    Inventors: Lars Winther, Marc Key, Kristopher S. Buchanan, John Favuzzi, Benno Guggenheimer
  • Patent number: 8216511
    Abstract: A specimen rack and a specimen carrier system includes a luminous body disposed on a vicinity of a specimen container loading slot to notify, to an operator, information concerning an analyzing situation and condition of the specimen contained in the specimen container held by the specimen rack.
    Type: Grant
    Filed: May 29, 2008
    Date of Patent: July 10, 2012
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Kiyoteru Noguchi, Hitoshi Ohtake, Yoshimitsu Takagi, Takuya Yamaguchi, Yoshiaki Saito, Yasuaki Takebe
  • Patent number: 8216846
    Abstract: A method and a system for use of treatment liquids in an apparatus for staining of tissue specimens on microscope slides, wherein the apparatus comprises a plurality of vessels (4) for receiving different liquids for treatment of the tissue specimens, a plurality of tanks (11) for treatment liquids, connecting lines (15) between the tanks and the vessels, a plurality of pumps (13) connected on the connecting lines, and a control unit for control of the apparatus and the liquid treatment by means of a data program, wherein the control unit is arranged for selective control of the relevant pumps (13), so that vessels (4) to be used in a staining process, are filled with liquid (14) at the start of the staining process, and so that the liquid-filled vessels (4) are emptied automatically when they are no longer to be used in the staining process.
    Type: Grant
    Filed: December 22, 2005
    Date of Patent: July 10, 2012
    Assignee: Dako Instrumec AS
    Inventors: Øystein Ljungmann, Torstein Ljungmann
  • Patent number: 8211701
    Abstract: A system and method for automated processing of nucleic acids and other samples includes a disposable container comprising a tray and a flexible barrier. The barrier is configured to seal with a top edge of the tray, providing a closed, aseptic work area within the sealed tray. A pipette head and/or other sample manipulation device can be attached to the inside of the barrier, and the barrier can include an interface for a robotic arm or other device. When the barrier is sealed over the tray, the barrier separates the contents of the tray from the robot or other manipulation device. The barrier can be flexible, and allow the robotic arm to move the pipette head throughout the work area of the tray. All samples, reagents, pipette tips and other tools or devices for processing nucleic acid samples may remain within the closed compartment provided by the container during processing.
    Type: Grant
    Filed: September 19, 2011
    Date of Patent: July 3, 2012
    Assignee: Argos Therapeutics, Inc.
    Inventors: Simon Jonathon Spence, Richard Alexander Grant, Timothy Doyle Peele, William Samuel Hunter, Ashraf F. Abdelmoteleb, David Thomas Kneen, Robert Alister Neil, Simon Harris
  • Publication number: 20120164735
    Abstract: A method is described for distributing samples within an automated analyzer from a linear arrangement of sample vessels to a processing plate in a two-dimensional n×m arrangement wherein samples are sorted, followed by transfer with a pipetting device with a linear arrangement to a processing vessel in a two-dimensional n×m arrangement and subsequent processing of samples using a second pipetting device which has a two-dimensional n×m arrangement.
    Type: Application
    Filed: June 27, 2011
    Publication date: June 28, 2012
    Applicant: ROCHE MOLECULAR SYSTEMS, INC.
    Inventors: Paul Frank, Andreas Gisler, Robert Huesler, Rolf Knobel, Siegfried Mueller, Urs Schnieper, Heinz Trueeb
  • Publication number: 20120149127
    Abstract: The present invention is to present a sample analyzer for analyzing a target substance in a sample by carrying out a target substance separating process for separating a complex containing the target substance and a magnetic particle from other substances other than the complex. The sample analyzer executes the target substance separating process with respect to a second container held by a second holder with a second nozzle while executing the target substance separating process with respect to a first container held by a first holder with a first nozzle, and completes the target substance separating process with respect to the first container with the first nozzle and completes the target substance separating process with respect to the second container with the second nozzle.
    Type: Application
    Filed: December 9, 2011
    Publication date: June 14, 2012
    Inventors: Hiroto Toyoshima, Kazunori Mototsu
  • Patent number: 8197754
    Abstract: The invention provides a small-sized automatic analyzer being compact, enabling a large number of analysis items to be carried out, and having a high processing speed. The automatic analyzer is particularly suitably applied to a medical analyzer used for qualitative/quantitative analysis of living body samples, such as urine and blood. A plurality of sample dispensing mechanism s capable of being operated independently of each other are provided to suck a sample from any one of a plurality of sample suction positions and to discharge the sucked sample to any one of a plurality of positions on a reaction disk. The automatic analyzer having a high processing capability can be thus realized without increasing the system size.
    Type: Grant
    Filed: September 30, 2010
    Date of Patent: June 12, 2012
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Hideyuki Yanami, Isao Yamazaki, Masaaki Hanawa, Hitoshi Otake
  • Publication number: 20120141326
    Abstract: A sample analyzer is disclosed. The sample analyzer comprises: a reader for reading ID of a sample from a sample container; an aspirator that aspirates a sample in a sample container; an analyzing section that analyzes the aspirated sample; a manual input receiver for receiving a manual input of an ID of a sample; an start instruction receiver for receiving a start instruction to cause the aspirator to aspirate a sample; and a controller. When receiving the start instruction without receiving the manual input, the controller controls the reader to read an ID from a sample container and then controls the aspirator to aspirate the sample from the sample container. When receiving the start instruction after receiving the manual input, the controller controls the aspirator to aspirate a sample without reading of an ID of the sample.
    Type: Application
    Filed: November 30, 2011
    Publication date: June 7, 2012
    Applicant: SYSMEX CORPORATION
    Inventor: Keisuke Kuwano
  • Patent number: 8192685
    Abstract: As an elegant solution for minimizing false positives returned by a sensor tuned to an analyte molecule, filters constructed of carbon nanotubes are positioned relative to the sensor to limit the sensor to being exposed to molecules within a defined range of sizes, with too-big molecules being excluded from reaching the sensor by one filter, and too-small molecules being pumped out through another, finer filter before the sensor is operated.
    Type: Grant
    Filed: March 13, 2009
    Date of Patent: June 5, 2012
    Assignee: Advanced Concepts and Technologies International, L.L.C.
    Inventor: Stephen J. Lukasik
  • Patent number: 8187535
    Abstract: An analytical system and method that enables more efficient transport of movable devices (22) among stations (24, 25, 26). According to one aspect of the invention, the system and method permit operational timesharing of a transport mechanism (34) for the movable devices. According to another aspect of the invention, control of the transport mechanism is effected on an event-driven basis. The invention has particular application to an adaptive, motion and fluids system for automating the sample handling/management process associated with analytical processes and especially bioanalytical processes such as introducing samples into LC and HPLC systems.
    Type: Grant
    Filed: June 14, 2005
    Date of Patent: May 29, 2012
    Assignee: Parker-Hannifin Corporation
    Inventors: Thomas R. Londo, Andreas Weiss, Charles C. Schelberg, Jr.
  • Patent number: 8187536
    Abstract: A system (100) and a method for the unequivocal allocation of histological cassettes (30) and specimen slides (60) is described. The system encompasses a microtome (1) and at least one reading unit (80). The data (33) of the histological cassette (30) and the data (33) of the at least one specimen slide (60) are read by means of the reading unit (80). The reading unit (80) is provided with at least one indicating element (83) that outputs a signal in accordance with the degree of correspondence between the data (33) of the histological cassette (30) and the data (33) on the specimen slide (60).
    Type: Grant
    Filed: December 3, 2010
    Date of Patent: May 29, 2012
    Assignee: Leica Biosystems Nussloch GmbH
    Inventors: Dag Graupner, Rolf Metzner
  • Publication number: 20120128534
    Abstract: An automatic analyzer has a noncontact identification medium with an antenna, a communication device for communicating with the noncontact identification medium, a container for containing a liquid, and a container holding mechanism in which the container is to be placed, the antenna being placed in an asymmetric position relative to the container. The automatic analyzer includes an identification mechanism. When the noncontact identification medium provided for the container cannot communicate with the communication device, the identification mechanism moves the container a predetermined distance by driving the container holding mechanism, causes the noncontact identification medium to communicate with the communication device, and identifies an orientation of the container placed in the container holding mechanism.
    Type: Application
    Filed: July 14, 2010
    Publication date: May 24, 2012
    Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION
    Inventors: Yusuke Minemura, Takuya Yamaguchi
  • Patent number: 8182745
    Abstract: An automatic analyzer having a positioning member connected to a nozzle support jig used to install a rinse nozzle having a suction member. The positioning member is present at a lower position than that of the suction member, has a vertically movable construction, and during a downward movement of the rinse mechanism, is brought close to/inserted into the reaction cuvette earlier than the suction member. Thus, the positioning member adjusts an inserting position of the suction member appropriately if the stopping position of the reaction cuvette deviates.
    Type: Grant
    Filed: August 28, 2008
    Date of Patent: May 22, 2012
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Hideyasu Chiba, Katsuaki Takahashi
  • Publication number: 20120122231
    Abstract: The present invention relates to a specimen testing device and method thereof, and it is an object of the present invention to provide a compact and reliable specimen testing device and method thereof.
    Type: Application
    Filed: June 4, 2010
    Publication date: May 17, 2012
    Applicant: UNIVERSAL BIO RESEARCH OCO., LTD.
    Inventor: Hideji Tajima
  • Publication number: 20120122705
    Abstract: Described herein is a sample preparation device including a sample delivery source, an inline means of transferring the sample from the sample source into a deformable channel within a pressure vessel, and out of the channel into downstream analysis components, a deformable channel disposed within the pressure vessel, the deformable channel having an inlet end and an outlet end fluidly connectable to high pressure valves and a means to measure the fluid pressure within the deformable channel, an external source of a controlled pressurized fluid fluidly connectable to the pressure vessel and a controller system that monitors and controls the sample fluid pressure by control of the external pressure vessel fluid.
    Type: Application
    Filed: August 18, 2011
    Publication date: May 17, 2012
    Applicant: PRESSURE BIOSCIENCES, INC.
    Inventors: Edmund Y. Ting, Alexander Lazarev
  • Patent number: 8180573
    Abstract: Disclosed is a sample processing apparatus, comprising: a sample processing unit for processing a sample with an auxiliary item used to process the sample; an output device for outputting a processing result by the sample processing unit; and a controller for determining whether or not the auxiliary item is appropriate for the sample processing by sample processing unit, and controlling, when determining that the auxiliary item is not appropriate for the sample processing by the sample processing unit, the output device so as to output the processing result and reliability information showing that the processing result has a low reliability. Also disclosed is a method for outputting the processing result by the sample processing apparatus and a computer program product.
    Type: Grant
    Filed: January 22, 2009
    Date of Patent: May 15, 2012
    Assignee: Sysmex Corporation
    Inventor: Shunsuke Ariyoshi
  • Publication number: 20120108461
    Abstract: An assay device and method of use thereof includes a sample tray comprising a plurality of sample wells having a first volume, and a slide tray comprising a slide, and a liquid dispenser. The slide comprises a plurality of reaction sites on a bottom surface of the slide. The liquid dispenser is configured to dispense a plurality of liquid samples into the sample wells. The sample wells are configured to hold the liquid samples. Each of the liquid samples has a second volume such that the second volume exceeds the first volume and each of the liquid sample sits within and above one of the sample wells. The slide tray and the sample tray are configured such that the slide tray can be placed onto the sample tray, at least one of the reaction sites can be positioned directly above at least one of the sample wells containing a liquid sample, and the liquid sample can be drawn onto the reaction site upon the liquid sample contacting the bottom surface of the slide.
    Type: Application
    Filed: October 31, 2011
    Publication date: May 3, 2012
    Inventors: John E. Bussan, Michael R. Nelson, Pat N. Morgan, Sergey V. Rozhok, Jeff Rendlin
  • Publication number: 20120107793
    Abstract: A sample processing system comprising: a transporting device that transports a sample; a plurality of sample processing devices that are arranged along a transport path for the sample transported by the transporting device and configured to process the sample transported by the transporting device based on a processing order; a controller configured to receive a first processing order for the sample and control the transporting device to transport the sample based on the received first processing order, and configured to receive a second processing order for the sample additionally and control the transporting device to transport the sample based on the received second processing order; and a display, wherein the controller is configured to prompt the display to show progress information indicating a progress status of processing the sample with respect to each of the first and second processing orders. A method of processing sample in a sample processing system.
    Type: Application
    Filed: October 24, 2011
    Publication date: May 3, 2012
    Inventor: Hiroo Tatsutani
  • Patent number: 8163239
    Abstract: The sample analyzer comprises a transporting device for transporting a rack for holding a plurality of containers containing samples respectively and having a recording part in which identifying information has been recorded that identifies the rack, a reading device for reading the identifying information from the recording part of the transported rack, an aspirating device including an aspirating tube for aspirating the sample from the container, a controller for controlling the operation of the aspirating device based on the identifying information read by the reading device, and an analyzing device for analyzing a measurement sample that includes the aspirated sample.
    Type: Grant
    Filed: August 17, 2007
    Date of Patent: April 24, 2012
    Assignee: Sysmex Corporation
    Inventor: Kyozo Fujita
  • Patent number: 8163564
    Abstract: A computer for receiving first and second sample attribute information regarding attributes of a sample, for determining parameter identification information for identifying a smear control parameter on the basis of the first sample attribute information, for generating first and second instruction to make a smear preparing apparatus prepare a smear of a sample, the first instruction including the parameter identification information, and the second instruction including the second sample attribute information, for transmitting the first and second instruction to the smear preparing apparatus is disclosed.
    Type: Grant
    Filed: September 8, 2005
    Date of Patent: April 24, 2012
    Assignee: Sysmex Corporation
    Inventors: Toshio Watanabe, Mieko Asada
  • Patent number: 8158063
    Abstract: A biosensor package structure with a micro-fluidic channel is provided. The biosensor package structure includes a substrate, a biochip, and a cover. The substrate has a first surface, a second surface, and an opening. The biochip is attached on the first surface. A bio-sensing area of the biochip is exposed to the opening of the substrate. The cover is attached on the second surface to cover the opening so as to form a micro-fluidic channel. By implementing the invention, the manufacturing process of the biosensor is simplified and the productivity is increased.
    Type: Grant
    Filed: December 12, 2008
    Date of Patent: April 17, 2012
    Assignee: National Chip Implementation Center National Applied Research Laboratories
    Inventors: Chin-Fong Chiu, Ying-Zong Juang, Hann-Huei Tsai, Chen-Fu Lin
  • Patent number: 8158439
    Abstract: The present invention is to present a sample analyzer which is automated even when measuring a small amount sample and is capable of improving a measurement precision. The sample analyzer S comprises a sample preparation section for preparing a measurement sample; a detector D3 for detecting an analyte contained in the measurement sample; and a controller 100 being configured to 1) control the sample preparation section so as to prepare a first measurement sample of a first dilution ratio, when measuring an ordinary amount sample; and 2) control the sample preparation section so as to prepare a second measurement sample of a second dilution ratio higher than the first dilution ratio, when measuring a small amount sample.
    Type: Grant
    Filed: July 16, 2008
    Date of Patent: April 17, 2012
    Assignee: Sysmex Corporation
    Inventor: Masaharu Shibata
  • Patent number: 8158061
    Abstract: A slide stainer assembly is disclosed. The slide stainer includes a slide carrier that is configured to carry one or more laboratory slides and a plurality of slide processing stations for processing the slides. A transport member including a plurality of engagement portions is configured for releasably engaging the slide carrier. A drive mechanism is coupled to the transport member. The drive mechanism is configured to move the transport member in a cyclical path such that, in the course of one cycle, the transport member engages a slide carrier docked in a first station, removes the slide carrier from the first station, docks the slide carrier in a second station and returns to the first station to engage another slide carrier.
    Type: Grant
    Filed: December 10, 2008
    Date of Patent: April 17, 2012
    Assignee: Rushabh Instruments, LLC
    Inventors: Preyas Shah, Leonard C. Wagner
  • Publication number: 20120087830
    Abstract: A sample analyzer comprising: a sample dispenser for dispensing a sample into a reaction container; a sample transporter for sequentially transports a plurality of reaction containers along a transporting path; a processing station including a plurality of processing sections and a transferring section that transfers a reaction container between the sample transporter and the processing sections; and a controller is disclosed. The sample dispenser sequentially dispenses samples at intervals. The controller alternates the interval when problem occurred at any of the processing sections.
    Type: Application
    Filed: October 3, 2011
    Publication date: April 12, 2012
    Inventor: Yuji Wakamiya
  • Patent number: 8155791
    Abstract: Methods and systems for creating dynamic performance measures (DPMs) for an IBA manufacturing process. Included is a method for monitoring an Isobutyl Alcohol (IBA) recovery system that includes computing at least one of an amount of IBA recovered from the IBA recovery system and an amount of waste material produced from the IBA recovery system, and displaying at least one of the recovered IBA and the waste material produced based on time. The method also includes computing a cost saved based on a cost of virgin IBA and the amount of IBA recovered. Computing an amount of waste material includes measuring waste material flow, and computing a cost of waste material management based on the measured waste material flow and a cost per unit volume to dispose of waste material. The IBA recovery system can include an evaporation IBA recovery system and/or a distillation IBA recovery system.
    Type: Grant
    Filed: June 7, 2011
    Date of Patent: April 10, 2012
    Assignee: Invensys Systems, Inc.
    Inventor: Russell Barr
  • Patent number: 8150552
    Abstract: A controller for a bathing unit system comprising a memory unit for storing program instructions, an interface for establishing a communication link with an external memory medium and a processing unit. The controller is operative for controlling a set of bathing unit components at least in part on the basis of the program instructions stored in the memory unit. The external memory medium stores update information associated with the program instructions and relevancy information indicative of a characteristic of the update information. The processing unit is operative for detecting the presence of an external memory medium at the interface, accessing the relevancy information stored in the memory medium, processing the relevancy information and causing the program instructions to be updated on the basis of the update information.
    Type: Grant
    Filed: February 25, 2008
    Date of Patent: April 3, 2012
    Assignee: Gecko Alliance Group Inc.
    Inventors: Christian Brochu, Mathleu Robitaille
  • Patent number: 8149402
    Abstract: The preferred embodiments of the invention is an optical system for a flow cytometer including a flow channel with an interrogation zone, and an illumination source that impinges the flow channel in the interrogation zone from a particular direction. The optical system preferably includes a lens system and a detection system. The lens system preferably includes multiple lens surfaces arranged around the flow channel and adapted to collect and collimate light from the interrogation zone. The detection system preferably includes multiple detectors adapted to detect light from the lens system. Each detector preferably includes a local filter that independently filters for specific wavelengths. Thus, the user may easily swap the filters in any order to achieve the same detection parameters.
    Type: Grant
    Filed: August 22, 2008
    Date of Patent: April 3, 2012
    Assignee: Accuri Cytometers, Inc.
    Inventors: Collin A. Rich, Richard L. Fisher, Nathaniel C. Bair
  • Publication number: 20120077282
    Abstract: A cartridge and cartridge system for use in an apparatus for analyzing a sample are provided. The system has a plurality of cartridges for different applications for a multimode instrument. The cartridges are removably engaged with a cartridge support of the apparatus in a “plug-in” format such that one cartridge may be removed from the apparatus and another cartridge may be easily installed. The cartridge support includes a plurality of cartridge positions that receive cartridges concurrently. One of the cartridges may be a luminescence cartridge that includes an integrated detector that is movable toward and away from a sample carrier of the apparatus, and thus toward and away from a sample located at the sample carrier.
    Type: Application
    Filed: December 5, 2011
    Publication date: March 29, 2012
    Applicant: MOLECULAR DEVICES, LLC
    Inventors: Michael Katzlinger, Josef J. Atzler, Daniel M. Stock
  • Patent number: 8137620
    Abstract: An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations, or modules, in which discrete aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automatically preparing a specimen sample, incubating the sample at prescribed temperatures for prescribed periods, performing an analyte isolation procedure, and ascertaining the presence of a target analyte. An automated receptacle transporting system moves the reaction receptacles from one station to the next.
    Type: Grant
    Filed: October 9, 2007
    Date of Patent: March 20, 2012
    Assignee: Gen-Probe Incorporated
    Inventors: Kelly G. Ammann, Robert E. Schneider, Robert J. Smith