Closing Or Opening Means, E.g., Corks, Bungs [b01l 3/14c] Patents (Class 422/916)
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Patent number: 10143989Abstract: Devices, systems and methods for making and handling liquid samples are disclosed.Type: GrantFiled: May 7, 2014Date of Patent: December 4, 2018Assignee: GENCELL BIOSYSTEMS LTD.Inventors: Brian Barrett, Patrick Tuohy, Caitriona Ryan, Mark McCabe
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Patent number: 8998000Abstract: A mechanical separator for separating a fluid sample into first and second phases within a collection container is disclosed. The mechanical separator may have a separator body having a through-hole defined therein, with the through-hole adapted for allowing fluid to pass therethrough. The separator body includes a float, having a first density, and a ballast, having a second density greater than the first density. A portion of the float is connected to a portion of the ballast. Optionally, the float may include a first extended tab adjacent a first opening of the through-hole and a second extended tab adjacent the second opening of the through-hole. In certain configurations, the separator body also includes an extended tab band disposed about an outer surface of the float. The separator body may also include an engagement band circumferentially disposed about at least a portion of the separator body.Type: GrantFiled: May 14, 2010Date of Patent: April 7, 2015Assignee: Becton, Dickinson and CompanyInventors: Jamieson W. Crawford, Ravi Attri, Christopher A. Battles, Benjamin R. Bartfeld, Gregory R. Hires
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Patent number: 8845623Abstract: A film with a tissue section is placed with the tissue section downward on a microscope slide and the microscope slide positioned in the object plane of an inverse microscope; where an adhesive tape is arranged, with a bonding agent downward, above the film and therefore above the tissue section; wherein the next step, tissue to be isolated is excised by a focused laser beam, which also divides the film; whereupon removal of the adhesive tape from the microscope, the excised tissue pieces adhere to the adhesive tape, and the remnant of the film and of the tissue section remains adhering to the microscope slide.Type: GrantFiled: February 6, 2007Date of Patent: September 30, 2014Assignee: Molecular Machines & Industries AGInventor: Norbert Leclerc
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Patent number: 8794452Abstract: A mechanical separator for separating a fluid sample into first and second phases within a collection container is disclosed. The mechanical separator may have a separator body having a through-hole defined therein, with the through-hole adapted for allowing fluid to pass therethrough. The separator body includes a float, having a first density, and a ballast, having a second density greater than the first density. A portion of the float is connected to a portion of the ballast. Optionally, the float may include a first extended tab adjacent a first opening of the through-hole and a second extended tab adjacent the second opening of the through-hole. In certain configurations, the separator body also includes an extended tab band disposed about an outer surface of the float. The separator body may also include an engagement band circumferentially disposed about at least a portion of the separator body.Type: GrantFiled: August 1, 2013Date of Patent: August 5, 2014Assignee: Becton, Dickinson and CompanyInventors: Jamieson W. Crawford, Ravi Attri, Christopher A. Battles, Benjamin R. Bartfeld, Gregory R. Hires
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Patent number: 8691524Abstract: A film (14) with a tissue section (10) is placed with the tissue section (10) downward on a microscope slide (18) and the microscope slide (18) positioned in the object plane of an inverse microscope; where an adhesive tape (20) is arranged, with a bonding agent (22) downward, above the film (14) and therefore above the tissue section (10); wherein the next step, tissue (36) to be isolated is excised by a focused laser beam, which also divides the film (14); whereupon removal of the adhesive tape (20) from the microscope, the excised tissue pieces (36) adhere to the adhesive tape (20), and the remnant of the film (14) and of the tissue section (10) remains adhering to the microscope slide (18).Type: GrantFiled: February 9, 2011Date of Patent: April 8, 2014Assignee: Molecular Machines & Industries AGInventor: Norbert Leclerc
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Patent number: 8535905Abstract: A film (14) with a tissue section (10) is placed with the tissue section (10) downward on a microscope slide (18) and the microscope slide (18) positioned in the object plane of an inverse microscope; where an adhesive tape (20) is arranged, with a bonding agent (22) downward, above the film (14) and therefore above the tissue section (10); wherein the next step, tissue (36) to be isolated is excised by a focused laser beam, which also divides the film (14); whereupon removal of the adhesive tape (20) from the microscope, the excised tissue pieces (36) adhere to the adhesive tape (20), and the remnant of the film (14) and of the tissue section (10) remains adhering/to the microscope slide (18).Type: GrantFiled: July 24, 2002Date of Patent: September 17, 2013Assignee: Molecular Machines and Industries AGInventor: Norbert Leclerc
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Patent number: 8491854Abstract: A test tube insert includes a flange having a width greater than a width of a mouth of a larger test tube into which the insert is to be inserted. The flange defines a first central opening. An annulus extends integrally downward from the flange. The annulus includes a fenestrated wall and a floor defining a second central opening. A small test tube body, smaller than the larger test tube, extends integrally downward from the floor of the annulus with the second central opening forming a mouth of the small test tube body. The test tube insert is disposed in the mouth of the larger test tube. Fluid is transferred through the central opening and the fluid fills the small test tube body of the test tube insert and flows through the fenestrated wall once the small test tube body is full into the larger test tube.Type: GrantFiled: November 8, 2010Date of Patent: July 23, 2013Assignee: King Saud UniversityInventor: Abdullah Khalid Al-Rasheed
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Patent number: 8328024Abstract: A separator that uses centrifugation to fractionate a suspension such as blood comprises a separation container and a buoy. The buoy is carried in the separation container and has a tuned density that is configured to reach an equilibrium position in a suspension. The guide surface is carried on the buoy upper surface and is inclined to an accumulation position near a buoy perimeter. The buoy suspension fractionation system can be used in a method of isolating a fraction from a suspension, and in a method for re-suspending particulates for withdrawal.Type: GrantFiled: August 4, 2011Date of Patent: December 11, 2012Assignees: Hanuman, LLC, Biomet Biologics, LLCInventors: Michael D. Leach, Randel Dorian, Jacy C. Hoeppner
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Patent number: 8216530Abstract: A reagent tube configured with a stellated shaped pattern, on its bottom interior surface, configured to facilitate complete or near-complete withdrawal of fluid from the tube, via a pipette tip. The reagent tube may be used for transporting reagents and for carrying out processing operations on biological samples with the reagents, such as preparing polynucleotides extracted from the sample for amplification.Type: GrantFiled: October 14, 2010Date of Patent: July 10, 2012Assignee: HandyLab, Inc.Inventors: Kalyan Handique, Theodore Springer
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Patent number: 8062520Abstract: A system for pressurized liquid extraction of solid samples including quick-connect, threadless columns for holding the solid sample is disclosed. A pressurized liquid extraction (PLE) module continuously performs extraction on the solid sample to yield liquid sample. The quick-connect columns include a threadless, cylindrical tube and end cap assemblies, which are structured and arranged to provide a tight interference fit with the inner surface of the annulus of the column portion and with top and bottom cup rings.Type: GrantFiled: August 21, 2007Date of Patent: November 22, 2011Assignee: Fluid Management Systems, Inc.Inventor: Hamid Shirkhan
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Patent number: 7371355Abstract: A reagent vessel cap includes an elastic sealing member having radial slits from the center toward the outer periphery, the sealing member being arranged on the opening of a vessel body supported by a cap body, for shielding a reagent contained in the vessel from outside air; and a pressurizing member attached to the cap body above the sealing member and retained in position by the biasing force of a built-in spring member, for opening the sealing member downward along the slits by the pressure from above and returning to position by relaxing of the pressure.Type: GrantFiled: November 21, 2003Date of Patent: May 13, 2008Assignee: Fujirebio Inc.Inventors: Hiroyuki Takahashi, Eiichiro Tanaka, Hiroyuki Nakamura
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Patent number: 6936319Abstract: A tube, preferably a centrifuge tube, molded of a blend of 25-35 weight percent of polystyrene and 75-65 weight percent of styrene-butadiene rubber block copolymer has improved performance compared to a tube of pure copolymer.Type: GrantFiled: January 17, 2002Date of Patent: August 30, 2005Assignee: Becton, Dickinson and CompanyInventors: John G. McCann, Daniel S. Banner, Louis S. Beres, III, Joseph A. Repp, Robert E. Alquesta
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Patent number: 6277331Abstract: A holding device for body fluid, tissue parts and tissue culture media includes a cylindrical holding container having a container wall with an inner surface defining an inner space, a first open end face having a diameter which is at least equal to the diameter of the inner space, and a second open end face having a conical sealing surface tapering inwardly in the direction of the inner space. A first closure device closes the first open end face and a second closure device closes the second end face. The second closure device includes a solid conical seal body 44 having a sealing surface conforming to the conical sealing surface of the second open end face and an outer end face of a larger diameter than that of an inner end face that faces the inner space. A retaining member 45 abuts the outer end face and is coupled to the outer container wall surface for holding the seal body in a sealing position in the second open end face.Type: GrantFiled: October 15, 1999Date of Patent: August 21, 2001Assignee: C. A. Greiner & Söhne Gesellschaft mbHInventor: Franz Konrad
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Patent number: 6190619Abstract: Systems and methods for synthesizing chemical compounds using a plurality reaction vessels. In particular, the present invention provides a synthesis apparatus capable of holding a plurality of reaction vessels for parallel synthesis of multiple discrete compounds or for combinatorial libraries of compounds. In one embodiment, a synthesis apparatus comprises a frame having a plurality of reaction vessel-holding openings and a plurality of valves for use in parallel synthesis of a plurality of compounds within reaction vessels.Type: GrantFiled: June 10, 1998Date of Patent: February 20, 2001Assignee: Argonaut Technologies, Inc.Inventors: Christopher Kilcoin, Steve Miller, Terry Long