Abstract: The present invention relates to a suction device (1) to be used together with a pipette, in particular a Pasteur pipette. The suction device comprises a base element (2) with the bore (2a) for the insertion of a pipette (5), and a body connected to the base element, wherein the interior of the body is hollow, wherein at least the body is made of a flexible material, so that the inner volume of the body (3) is variable. Herein, the base element is formed in a polygonal or elliptic shape, so that the shape of the base element is not round and hence prevents a rolling of the suction device over a lab bench or the like.

Abstract: In at least one embodiment, there is a nail polish applicator for nail polish, the applicator comprising: a container body, at least one cap or lid body which is coupled to the container body. There is at least one brush comprising a shaft coupled to the cap wherein the shaft has a storage body disposed therein. There is at least one air suction unit configured to draw nail polish into the storage body. There is also a compressor comprising an elastic pressing body configured to compress the air suction unit to draw nail polish into the storage body. The compressor is coupled to the cap. The compressor comprises at least one protrusion and at least one leaf spring coupled to the cap, such that when the protrusion is pressed, it compresses the suction unit to draw nail polish into the storage body.

Abstract: A peptide synthesis instrument can be used for small scale peptide synthesis. The instrument can include several unique features, including a compression style reaction vessel permitting quick setup of the reaction vessel, a double reaction vessel system permitting efficient mixing without loss of solvent or solvent-to-resin contact, gravity-fed heated reservoirs establishing a fixed volume for delivery to the reaction vessel, fume-free solvent addition permitting solvent addition to fixed bottles, and an improved amino acid manifold assembly which reduces the number of components and increases the ease of use of the instrument. Each of these features improve upon the current state of the art in solid phase automated peptide synthesizers.

Abstract: Methods and devices for measuring the volume of a liquid sample transferred from a source to a destination by means of incremental dispensing of the sample into a destination vessel or by means of decremental aspiration of the sample from a source vessel, where the liquid sample is collected from a liquid having known optical absorbance at a known wavelength or within a defined part of the electromagnetic spectrum. The absorbance of the sample is measured by exposing the source or destination vessel to electromagnetic radiation before and after the transfer, and the liquid volume is determined on the basis of differential measurements of absorbance of the source or destination vessel.

Abstract: What is disclosed in the present invention is to provide a quantitative transfer pipette structure, wherein an anti-backflow compartment is configured in the first bulb. The dimensions and locations of the first bulb, the second bulb and the third bulb are specifically configured to aspirate and transfer a specific volume of the liquid to a container, mix the liquid with the substance in the container by pressing and releasing the specific bulbs, so as to achieve the effects of precise quantification and sufficient mixing.

Abstract: The invention relates to an apparatus for optically monitoring the dosing of a liquid to be pipetted for an automatic analysis unit. The apparatus comprises a dosing device, comprising a pipetting needle for pipetting the liquid, a lighting device for illuminating a drop of the liquid adhering to the pipetting needle, a camera with a set of optics to capture an image of the drop of the liquid, and an evaluation device for characterizing the drop of liquid by means of an automatic analysis of the image of the drop of liquid.

Abstract: The present disclosure relates to a medicament delivery device. The medicament delivery device comprises a housing, a needle and a reservoir. The needle is configured to project from a distal end of the housing. The reservoir is disposed in the housing and has a flexible wall. The medicament delivery device further comprises a dispensing member and a biasing member. The dispensing member is disposed in the housing and the biasing member is configured to bias the dispensing member to move in an arcuate path relative to the housing such that the dispensing member moves across the flexible wall of the reservoir to dispense medicament from the reservoir when the reservoir contains medicament.

Abstract: An on-body wearable bio-fluid collection and sensing device including an interface or interface surface comprising at least one biocompatible material for contacting a bodily part; at least one inlet for receiving the bio-fluid, at least one outlet for evacuating the bio-fluid, a plurality of semiconductor sensors configured to analyze the received bio-fluid, at least one reference electrode for biasing a bio-fluid gate of at least one of the semiconductor sensors, and at least one micro-fluidic or nano-fluidic channel in fluid communication with the at least one inlet, the at least one outlet and the at least one reference electrode; the at least one micro-fluidic or nano-fluidic channel includes the plurality of semiconductor sensors.

Abstract: An analyzing device has one end of a supplying capillary channel opened at a spot application section formed so as to protrude from an analyzing device main body. The supplying capillary channel is connected to a microchannel structure formed inside the analyzing device main body. A sample liquid is applied to the spot application section and is suctioned by a capillary force of the supplying capillary channel. The analyzing device is used for reading in which a suctioned solution is accessed. The analyzing device includes a leading end of the spot application section that has an inclined face. The end of the supplying capillary channel is opened on the inclined face.

Abstract: The present invention discloses a flow cell optical detection system comprising a light source, a flow cell and a light detector, wherein the light detector is arranged in a separate detector unit that is arranged to be releasably attached to a detector interface, the detector interface being in optical communication with the light source and comprises optical connectors for optically connecting the flow cell and the detector unit in the light path from the light source, and wherein the flow cell is an interchangeable unit arranged to be held in position by the detector unit when attached to the detector interface.

Abstract: The invention relates to a microfluidic system for processing biological samples comprising a transfer pipette; a platform adapted to provide at least one receiving chamber and configured to receive said transfer pipette, and a distal output chamber wherein a biological sample from the transfer pipette is dispensed into the output chamber when a centrifugal force is applied.

Abstract: A blood sampling device useful for collecting a blood sample from a separate vascular access device is described herein. The blood sampling device includes a body shaped and sized for partial insertion into a separate vascular access device. The body includes a reservoir defined within the body, which has an internal volume sufficient to contain enough blood for use in a diagnostic blood test. The body also includes a gas permeable vent disposed on the body, in which the gas permeable vent is in gaseous communication with the reservoir. When connected to a separate vascular access device the blood sampling device collects a blood sample as blood flows into the reservoir from the separate vascular access device and as gases pass out the reservoir via the gas permeable vent.

Abstract: The invention is directed to a device and a method for carrying out experiments of chemical, biochemical, biological and physical analysis, reaction and assay employing a reaction unit, in a preferred embodiment comprising: a capillarity reaction chamber, non-capillarity zone and bottom structure, which can use capillary action to quantitatively take up by itself and hold liquid in the reaction chamber. A multi-unit plate, which contains a number of reaction units on a plate frame, can be used for parallel experiments in conjunction with reservoir plate, waster pad, and liquid transfer guider.

Abstract: The pipetting method is directed to mounting and ejecting a disposable pipette tip. The pipetting system has one or more tip mounting shafts with an upper locking section and a lower sealing section. The upper locking section has outwardly extending lobes spaced around the mounting shaft and located above a stop member. The lower sealing section on the tip mounting shaft is located below the stop. As the mounting shaft is inserted into the collar of the disposable pipette, the collar distorts out of round and engages the lobes on the upper locking section of the tip mounting shaft. Contemporaneously, the lower sealing section of the mounting shaft seals against the barrel of the disposable pipette tip.

Abstract: A system for titrating liquids, with a syringe or tip, comprising a holding device and at least one tag and a metering equipment, comprising an additional holding device for holding the syringe or tip on the holding device, a reading device for reading the tag of the syringe or tip held by the additional holding device, a driving device having a motor, which is detachably coupled with a plunger of the syringe when the same is held by the additional holding device, or which is coupled with a plunger which is arranged in a cylinder which is coupled with the tip via a fluid conduit, when the same is held by the additional holding device, an operating device for operating the metering equipment and a control device, connected with the operating device, the reading device and the driving device, which controls the movement of the plunger depending of the tag of the inserted syringe or tip.

Abstract: A reaction unit containing a bottom part and a top part for pipetting a liquid, wherein the bottom part contains a reaction cavity with a permeable filter grid insert and the top part contains a reaction cavity which can be fixed on said bottom part and contains a cavity or covering for receiving a magnet.

Abstract: A disposable pipette tip having that is configured to mount on a tip mounting shaft having a locking section and a separate sealing section. The locking section has outwardly extending locking lobes circumferentially spaced around the mounting shaft and located above a stop member that separates the lower sealing section from the upper locking section. The collar flexes out of round when it is mounted over the locking lobes on the mounting shaft. The circumferential shelf on the tip isolates the tip barrel from distortion to enable robust sealing in the barrel below the shelf.

Abstract: A light beam guided liquid delivery device for tracking the placement of a sample by a liquid delivery device into a receptacle like a milliliter or microliter scale tube, or a microtiter plate, includes a liquid delivery device and a light beam generator. The light beam generator may be positioned on the outside or inside of the liquid delivery device. The light beam generator may be adapted to shoot a light beam below the tip of the liquid delivery device, whereby, a user may track the placement of the tip of the liquid delivery device via the light beam.

Abstract: Systems and apparatus for mixing, cooling, and distributing multiphase fluid mixtures within a reactor, wherein reactor internal apparatus of the present invention provides not only improved fluid mixing and distribution to each underlying catalyst bed surface, but also offers other advantages including: decreased mixing tray height; easier maintenance, assembly and disassembly; and decreased amounts of fabrication material. In an embodiment, fluid may be evenly distributed to a catalyst bed from a fluid distribution unit comprising a nozzle tray including a plurality of nozzles, wherein the nozzles include at least one liquid inlet disposed tangentially to an inner surface of the nozzle.

Abstract: The invention relates to a kind of volumetric pipet. It includes an outer casing. At the lower part of the outer casing, there is a fetching mouth which is detachably mounted to a liquid container. At the top of the outer casing, there is a detachably sealed top cover. Inside the outer casing, there is a hollow core with a top opening. There is an inlet mouth on the side wall of the core that corresponds to the fetching mouth. The internal wall of the outer casing can slide against the external wall of the core. The core's rotating or sliding along its longitudinal orientation makes the fetching mouth and the inlet mouth correspond or stagger. This invention provides an easy-to-operate, precise rationing, quick and sanitary volumetric pipet.

Abstract: An ergonomically designed pipette tip that can be securely mounted to a barrel of a pipetter yet is designed to substantially reduce the axial force necessary to install and eject the pipette tip from the pipetter. An improved pipette tip that includes the addition of a second elastomeric material and cooperative means for insuring uniform interference and depth of penetration of the pipetter barrel as successive barrels are inserted and ejected. Also disclosed is an improved multiple-tip configuration with similar features as the ergonomic pipette tip that can be mounted to multiple barrels of a multi-pipetter as one tip instead of 8 or 12 individual tips. The secondary elastomeric material allows for better sealing and eliminates alignment issues, high installation and ejection requirements while reducing the hand and thumb forces that due to repeated use will sometimes result in repetitive stress injury.

Abstract: A pipetting device with a displacement chamber, a flexible membrane delimiting the displacement chamber, a driving equipment for deforming the membrane, a coupling equipment between the driving equipment and the membrane for coupling the driving equipment with the membrane, an equipment for detachably holding a pipette tip, a connection channel between the displacement chamber and the equipment for detachably holding the pipette tip, and an aperture equipment, covering the edge region of the membrane with at least one adjustable aperture opening straight through which the central region of the membrane is deformable.

Abstract: Pipette tip made from plastics with an elongate, tubular body which comprises at a lower end a pipetting aperture, at an upper end a placement aperture (6) for placement on a receiving shank of a pipetting device, in the vicinity of the upper end a circumferential rib along a closed curve comprising different spacings from the lower end in different contour positions, a circumferential contact region on a surface of revolution on the inner face of the circumferential rib and at least one further rib extended from at least one position of the circumferential rib at a maximum distance from the lower end as far as the upper end.

Abstract: Hydrophobic coating compositions are provided as are processes to coat articles with the compositions. Extremely hydrophobic coatings are provided by the compositions. Durable, weatherable and scratch-resistant coatings are provided by compositions comprising a fluorinated component and an adhesion promoter compound. The adhesion promoter compound can include an alkoxy group, a furfuryl-containing ring structure, and a reactive group.

Abstract: A pipetting apparatus (1) comprises a fluidic space (7), to which a pressure transducer (11) with a pressure sensor (12) is attached with a gas filled space (15). The fluidic space (7) is defined by a pipette tip (2), a first tubing (5) that connects the pipette tip (2) to a pump (4), and an active part (6) of the pump (4). The pipetting apparatus (1) according to the present invention is characterized in that the pipetting apparatus (1) further comprises an impulse generating means (16, 18, 19) that is in operative contact with a column (10) of system liquid (8) inside the fluidic space (7). The impulse generating means (16, 18, 19) is designed to induce a vertical movement in this system liquid column (10), which results in a pressure variation in the gas filled space (15) that is pneumatically connected with the fluidic space (7).

Abstract: The present application is directed to pipette configurations, arrays of the same and methods for using such pipettes and arrays to accomplish electrical measurements, including whole cell and on cell measurements. In one aspect of the present invention, a pipette includes a hollow tubular section having a distal portion and a tip portion. A bubble is formed at the tip and includes an interior chamber in communication with the hollow tubular section at an end adjacent to the bubble portion. The bubble may have a diameter greater than the diameter of an adjacent portion of the hollow tubular section. An aperture is formed between the internal chamber and an exterior surface of the bubble to accommodate seal formation.

Abstract: A liquid pipetting apparatus for dispensing liquid of minute volume for use in a survey instruments of a hemanalysis machine, a genetic screening, and a pharmaceutical screening, etc., is disclosed. The liquid pipetting apparatus comprises a liquid holding member for holding the liquid, and capable of dispensing the liquid from one end, and a driving member for moving the liquid holding member forward and backward along the dispensing direction, the liquid holding member being moved by the driving means, thereby dispensing the liquid held on the liquid holding member.

Abstract: Laboratory pipette composed particularly of a transparent tube comprising one end for sampling a liquid and one suction end into which a piece of fibrous material is inserted with a color corresponding to at least one characteristic of the pipette and particularly to its nominal volume, characterized in that the piece of fibrous material is in the form of a braid of interlaced threads of synthetic fibers, the said braid being folded such that the fold thus formed is located towards the inside of the pipette, and a method of identifying at least one characteristic of the pipette.

Abstract: In an aspirating and dispensing/spraying device, a holder is screwed onto a tube, connected to a liquid supply line, in such a way that it is displaceable along the tube by rotation. The tube is surrounded at a distance by a coaxial sleeve, which is solidly anchored in the holder, having a discharge opening on its front end, which is conically narrowed, whose edge surrounds the front end of the tube, which carries a outlet opening, separated by a narrow annular gap from the tube. The sleeve carries a connecting piece laterally, to which a pressurized gas supply line is connected and which discharges eccentrically into the space between the sleeve and the tube, so that pressurized gas flowing in receives angular momentum. When the gas flows out of the annular gap, it mixes intensively with the liquid coming out of the outlet opening and forms a discharge cone made of a fine, symmetrical aerosol with the liquid.

Abstract: A pipettor head adapter allows the adaptation of pipettors having a set number of pipettor channels to successfully pipette microtiter trays having a different number of wells than the pipettor has pipettor channels. For example, in a pipettor having 384 channels for pipetting a 384 well microtiter tray, the pipettor head adapter of the present invention will allow a “stepping down” or adaptation, such that the pipettor with its 384 pipettor channels can successfully and reliably pipette microtiter trays having 96 wells. Such adaptation occurs without the need for special microtiter trays. Industry standard operations are then preserved, even though they were previously unavailable from such a pipettor.

Abstract: A micropipette for dispensing sequential, different sample solutions, including a substrate, an inlet port formed in or on the substrate, a cavity into which the sample solutions are poured through the inlet port and which is filled sequentially with the sample solutions, an introduction hole between each inlet port and cavity, an injection port for sequentially expelling the sample solutions formed in communication with each cavity, and a piezoelectric/electrostrictive element provided on at least one wall of the substrate adjacent each cavity.

Abstract: A fluid dispensing system and method includes a pump to aspirate and expel sample fluid, a fluid dispensing tip, and a metering station. The fluid dispensing tip includes a working fluid and an air gap where the air gap separates the working fluid from the sample fluid. The metering station receives a drop of sample fluid that is at least twice as large as the predetermined volume to ultimately be dispensed. The fluid dispensing tip then withdraws the predetermined volume of fluid from the sample fluid. Precise volumes are ascertained by prior knowledge of the geometry of the fluid dispensing tip and by using an imaging device to monitor an interface of either the sample fluid or working fluid with the air gap within the fluid dispensing tip. The system and method are capable of accurately dispensing very small volumes of sample fluid on the order of 10 picoliters. In addition, the system and method do not require large volumes of sample fluid to prime a pump mechanism.

Abstract: A bead dispensing system is provided for delivering small amounts of substances onto substrates. The system can include, for example, a movable support structure having an array of spaced-apart projections depending from its lower side. An attraction source, such as a vacuum, magnetic, and/or electrostatic force, is operable at each projection end region to attract and retain one bead. The projection array can be aligned with an array of bead-receiving regions of a substrate, e.g., an array of spaced-apart wells of a micro-plate or card. In one embodiment, a plurality of reagent-carrying beads are picked up, retained at respective projection end regions, and moved to a location over a multi-well plate. The beads are then released in a fashion permitting each bead to land in a respective well. The system of the invention is particularly useful for fabricating arrays of reagents.

Abstract: The present invention provides an improved apparatus and method for loading tips onto a pipettor. A means for applying removal force on the pipette tip box is provided so as to ensure that the box is dislodged from the pipette tips after the pipette tips have been forced onto the dispense head mandrels. In the preferred embodiment, the shuck arms are modified to incorporate springs such that when the engagement force is removed from the pipette tip box, the shuck arms are forced by the springs against the pipette tip box thereby displacing the pipette tip box from the pipette tips.

Abstract: A fixed volume liquid transfer device defined by a small bore tube having an open end for collection of liquids and a plunger in the tube is disclosed. A piston is mounted around the open end and an air plug is mounted in the piston adjacent the open end. Liquid in a test tube is transferred to a testing site by inserting the transfer device into the test tube. As the piston contacts the liquid, the liquid is pumped into the tube. As the transfer device is inserted further, the air plug is actuated to balance air pressure across the piston. The device may then be withdrawn from the test tube and transported to a test site. At the test site, the plunger is depressed to expel the liquid into a testing device.

Abstract: Laboratory vessels are coated on an operational surface thereof with a hydrophobic coating polymer or reactive monomer to form a coating having an exposed surface populated with 30% by area or more terminal trifluoromethyl groups. Laboratory vessels coated with such coating solutions are provided having extremely low surface energies and high resistance to solvent attack. Methods of forming hydrophobic coatings on laboratory vessels are also provided and include methods of forming exposed coating surfaces having populations of from about 30% by area to 100% by area trifluoromethyl groups. The hydrophobic coatings may be prepared from solutions, suspensions or powdered materials containing a fluoroalkyl ethylenically unsaturated monomer substantially free of any crosslinking, having from about 3 to about 20 carbon atoms, and containing at least one terminal trifluoromethyl group, or containing a polymerization product of such a monomer.