Over 60 To 62% Carbon Patents (Class 424/121)
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Patent number: 10499665Abstract: A complete ration, or diet, suitable for beef cattle in different fattening stages is provided, as well as a method for formulating the ration. All by-products of sugar manufacture are recycled and used to formulate the complete ration for beef cattle in different fattening stages, using sugarcane tip leaves and alkalized bagasse as raw materials, using molasses and corn flour as energy feed, using peanut bran, soybean residual, rapeseed meal, etc., as protein feed, using carbamide, dicalcium phosphate, limestone powder, bacteria strain and pre-mixture as other additives. The complete ration suitable for beef cattle in each growing stages can be flexibly formulated according to nutrients requirements of beef cattle in different growing stages. Comparing to the regular feed for the same fattening stage, the complete ration described can lead to a lower production cost and a lower ratio between feed and weight, and bring higher economic values.Type: GrantFiled: November 9, 2017Date of Patent: December 10, 2019Assignees: GUANGDONG PROVINCIAL BIOENGINEERING INSTITUTE (GUANGZHOU SUGARCANE INDUSTRY RESEARCH INSTITUTE), GUANGXI STATE FARMS JINGUANG DAIRY INDUSTRY CO., LTD.Inventors: Wenxing Tan, Ximiao Yi, Jiazhou Wei, Dafeng Liang, Hongqiao Wei, Bu Ma, Zengwei Huang, Zhijian Wei, Zhaopeng Wu, Guowei Chang, Yu Zhang
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Patent number: 9913858Abstract: The invention described in this specification relates to the prevention and treatment of alkaloid-induced toxicosis in pasture grazing animals.Type: GrantFiled: November 20, 2014Date of Patent: March 13, 2018Assignees: MEAT & LIVESTOCK AUSTRALIA LIMITED, CHARLES STURT UNIVERSITYInventors: Jane Quinn, Scott Edwards, Martin Combs
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Patent number: 7652265Abstract: An air treatment system includes a housing defining a chamber, and an ultraviolet lamp positioned within the chamber. The housing further defines an air inlet at a first end portion of the housing and an air outlet at a second end portion of the housing opposing the first end portion. The chamber provides flow communication between the air inlet and the air outlet. At least one ultraviolet lamp is positioned within the chamber. The at least one ultraviolet lamp is positioned about a first axis and includes a first end and a second end spaced with respect to the first end along the first axis. The at least one ultraviolet lamp is configured for facilitating inactivating contaminants within air channeled through the chamber.Type: GrantFiled: December 11, 2006Date of Patent: January 26, 2010Assignee: General Electric CompanyInventors: Gautam Subbarao, Mark Wayne Wilson, Anand Ganesh Joshi, Hemachandran Umakanthan, Ramnath Vaidyanathan
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Patent number: 6855524Abstract: The invention concerns a method for producing exopolysaccharides by fermenting micro-organisms characterised in that it consists in carrying out the fermentation in a nutrient medium comprising at least a source of carbon available to the micro-organisms and at least a source of nitrogen, said source being derived from a fraction of carob seed.Type: GrantFiled: September 6, 2000Date of Patent: February 15, 2005Assignee: Danisco USA Inc.Inventors: Olivier Nore, Jean-Luc Simon
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Patent number: 6482082Abstract: In a heating and/or air-conditioning system especially for an automobile with a blower housing and a distributor housing located in front of and below an instrument panel, provision is made such that the distributor housing can be separated toward the vehicle interior from the blower housing. The distributor housing has a front end facing the vehicle interior which fills a recess in the instrument panel provided for removing the distributor housing.Type: GrantFiled: November 23, 1998Date of Patent: November 19, 2002Assignee: Behr GmbH & Co.Inventors: Martin Derleth, Klaus Luz, Adem Hizli, Markus Schmid, Martin Stemmler, Walter Wolf
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Patent number: 6306629Abstract: The present invention is related to a new microorganism Streptomyces exfoliatus YJ-118 and a method for producing pravastatin sodium by using this microorganism which shows a strong tolerance to ML-236B and a high hydroxylation activity of ML-236B to pravastatin.Type: GrantFiled: December 29, 1999Date of Patent: October 23, 2001Assignee: Yungjin Pharmaceutical Ind. Co., Ltd.Inventors: Joo-Kyung Lee, Joo-Woong Park, Dong-Jin Seo, Sang-Choon Lee, Ji-Yoon Kim
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Patent number: 6207186Abstract: The invention provides novel compositions involving lamellar gels and methods for making them. These compositions and methods of the invention are significant improvements in the field of gels, macromolecular targeting and macromolecular delivery to various biological systems.Type: GrantFiled: February 13, 1998Date of Patent: March 27, 2001Assignee: The Regents of the University of CaliforniaInventors: Cyrus R. Safinya, Heidi E. Warriner, Stefan H. J. Idziak
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Patent number: 6171612Abstract: Lipopolyamines useful for the transfection of nucleic acid and methods of preparation thereof are disclosed. The lipopolyamines are of general formula I, in which R4 comprises at least one C10-C22 aliphatic radical.Type: GrantFiled: May 13, 1998Date of Patent: January 9, 2001Assignee: Aventis Pharma S.A.Inventors: G{acute over (e)}rardo Byk, Daniel Scherman, Bertrand Schwartz, Catherine Dubertret
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Patent number: 6165441Abstract: A method of therapeutical treatment of tumors, by photodynamic therapy comprising administering to a subject in need of said treatment an effective amount of a tumor-localizing photosensitizer consisting of a metal phthalocyanine, together with a minor amount of a tracer consisting of said metal phthalocyanine labelled with a radioactive isotope and non-invasively monitoring the concentration of said tracer in the target tumoral tissue and in the peritumoral tissue, thereby to identify the appropriate post-administration interval for performing the photodynamic therapy.Type: GrantFiled: August 24, 1995Date of Patent: December 26, 2000Assignee: Nycomed Amersham Sorin SRLInventors: Rodolfo Franceschini, Giulio Iori, Laura Polo, Giovanni Bocchiotti
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Patent number: 6149937Abstract: A process for the entrapment of amphiphilic compounds as uncharged or ionic with different mole ratios of phospholipid to the amphiphilic compound. Preparations of ionic species of amphiphilic compounds in the absence of crystals can be prepared, while preparations of uncharged amphiphilic compounds can be prepared with the compound exclusively entrapped inside the liposomes, or partly entrapped inside the liposomes with extraliposomal crystals.Type: GrantFiled: November 19, 1998Date of Patent: November 21, 2000Assignee: Vrije Universiteit BrusselInventors: Frederic Camu, Mokarram Alafandy, Robert Brasseur, Franz Legros, Oliver Bouffioux
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Patent number: 6143729Abstract: Novel amidinium derivatives of formula (I), wherein R1 is a cholesterol derivative or an alkylamino-NR'R" grouping, and each of R2 and R3 is independently a hydrogen atom or a grouping of formula (II), wherein each of R4 and R5 is independently a hydrogen atom or a grouping of formula (III), are disclosed. The corresponding pharmaceutical compositions, which are particularly useful in gene therapy for transferring therapeutic genes into cells, are also disclosed.Type: GrantFiled: September 11, 1998Date of Patent: November 7, 2000Assignee: Aventis Pharma S.A.Inventors: Jean-Marie Lehn, Pierre Lehn, Jean-Pierre Vigneron
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Patent number: 6143321Abstract: Liposomes formulations are designed to maximize the amount of poorly water-soluble active agent that can be carried by the liposome. Liposomes containing active agent in the lipid bilayer of the liposome, and/or entrapped within the liposome interior space in a micellar preparation are described. Methods of making such liposomes are presented.Type: GrantFiled: October 19, 1998Date of Patent: November 7, 2000Assignee: Duke UniversityInventors: David Needham, Ranjit S. Sarpal
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Patent number: 6132764Abstract: Polymerized liposome particles which are linked to a targeting agent and may also be linked to a contrast enhancement agent and/or linked to or encapsulating a treatment agent. The targeting imaging enhancement polymerized liposome particles interact with biological targets holding the image enhancement agent to specific sites providing in vitro and in vivo study by magnetic resonance, radioactive, x-ray or optical imaging of the expression of molecules in cells and tissues during disease and pathology. Targeting polymerized liposomes may be linked to or encapsulate a treatment agent, such as, proteins, drugs or hormones for directed delivery to specific biological sites for treatment.Type: GrantFiled: April 8, 1996Date of Patent: October 17, 2000Assignee: Targesome, Inc.Inventors: King Chuen Li, Mark David Bednarski, Richard Wood Storrs, Henry Y. Li, Francois Daniel Tropper, Curtis Kang Hoon Song, Dorothy Anna Sipkins, Jeremy Kenji Kuniyoshi
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Patent number: 6120795Abstract: A method for preparing liposomal suspensions which comprises preparing a solution of a poorly soluble protein or other poorly soluble compound and an encapsulating amount of a suitable lipid in an alcoholic solvent, injecting the resulting solution into an aqueous solution of appropriate ionic strength, and removing the alcoholic solvent by thin-film evaporation at the transition temperature of the liposomal suspension. This process is suitable for continuous production on an industrial manufacturing scale. It is of particular application in the preparation of KL4 pulmonary surfactant composition, wherein the thin film evaporation is conducted within the transition temperature range of the surfactant (approximately 35-50.degree. C.), thereby enhancing the KL4 peptide insertion into the lipid bilayer and leading to a product with reduced viscosity and enhanced surface tension lowering properties.Type: GrantFiled: March 4, 1997Date of Patent: September 19, 2000Assignee: Ortho Pharmaceutical Corp.Inventors: Robert Joseph Klimchak, Peter G. Glavinos, Jr., deceased
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Patent number: 6117852Abstract: The present invention discloses a boron-containing pharmaceutical composition useful in boron neutron capture therapy of hepatoma, which includes lipiodol, stibmicron boron powder, lecithin and unsaturated fatty acid. The lipiodol has a property of a high retention in hepatoma, the lecithin has a boron carrying capacity, and the unsaturated fatty acid has a function of rendering lecithin soluble in lipiodol.Type: GrantFiled: December 29, 1997Date of Patent: September 12, 2000Assignee: National Science CouncilInventor: Fong-In Chou
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Patent number: 6110916Abstract: The present invention discloses highly packed polycationic ammonium, sulfonium and phosphonium lipid compounds useful for making lipid aggregates for delivery of macromolecules and other compounds into cells. They are especially useful for the DNA-dependent transformation of cells. Methods for their preparation and use as intracellular delivery agents are also disclosed.Type: GrantFiled: November 6, 1998Date of Patent: August 29, 2000Assignee: Life Technologies, Inc.Inventors: Alberto Haces, Valentina C. Ciccarone
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Patent number: 6106859Abstract: The present invention provides a liposomal aerosol composition, comprising a pharmaceutical compound, a cationic lipid, (c) a neutral co-lipid; and (d) tryptone. Also provided is a nebulized cationic lipid:DNA suspension useful for lipid-DNA transfections, wherein said cationic lipid is bis(guanidinium)-tren-cholesterol.Type: GrantFiled: January 8, 1999Date of Patent: August 22, 2000Inventors: Charles L. Densmore, Jr., J. Vernon Knight, J. Clifford Waldrep, Berma M. Kinsey
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Patent number: 6103217Abstract: The presently claimed invention relates to polymeric assemblies which visibly change color in the presence of analyte. In particular, the presently claimed invention relates to liposomes comprising a plurality of lipid monomers, which comprises a polymerizable group, a hydrophilic head group and a hydrophobic tail group, and one or more ligands. Overall carbon chain length, and polymerizable group positioning on the monomer influence color change sensitivity to analyte concentrations.Type: GrantFiled: July 28, 1997Date of Patent: August 15, 2000Assignee: The Regents of the University of CaliforniaInventor: Deborah Charych
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Patent number: 6063400Abstract: This invention provides a liposomal construct for delivering a diagnostic or therapeutic agent to a mammal comprising a liposomal carrier, a diagnostic or therapeutic agent entrapped within or associated with said liposomal carrier and a sequestering agent distributed within said liposomal carrier to reduce leakage of the diagnostic or therapeutic agent from the liposomal construct prior to delivery.Type: GrantFiled: July 2, 1998Date of Patent: May 16, 2000Assignee: SDG, Inc.Inventors: W. Blair Geho, John R. Lau
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Patent number: 6056938Abstract: Cationic lipid compounds which comprise at least two cationic groups. The cationic lipid compounds are particularly suitable for use as carriers in the intracellular delivery of bioactive agents, including pharmaceuticals and genetic material. Compositions of the present cationic lipid compounds include suspensions, emulsions, micelles and liposomes.Type: GrantFiled: May 5, 1998Date of Patent: May 2, 2000Assignee: Imarx Pharaceutical Corp.Inventors: Evan C. Unger, Dekang Shen, Guanli Wu
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Patent number: 6048545Abstract: Substances, such as pharmaceuticals and cosmetics, are administered encapsulated within a lipid vesicle, by iontophoresis. An iontophoretic device which conforms to the contours of the body is also provided.Type: GrantFiled: July 22, 1996Date of Patent: April 11, 2000Assignee: BioZone Laboratories, Inc.Inventors: Brian C. Keller, Daniel L. Fisher, Stefan Kiss, Michael Mezei
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Patent number: 6045821Abstract: The present invention relates to a liposomal agent comprising liposomes having bound to a membrane thereof a chelated diagnostically or therapeutically effective metal ion. The chelating agent binding the metal ion has a macrocyclic chelant moiety with, attached to a single ring atom thereof, a lipophilic membrane associating moiety.Type: GrantFiled: May 29, 1997Date of Patent: April 4, 2000Assignee: Nycomed Salutar, Inc.Inventors: Martha Garrity, John Varadarajan, Alan David Watson
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Patent number: 6022874Abstract: The present invention relates to piperazine based amphilic cationic lipids useful for gene therapy, transfection, and introducing immunogenic compounds for the purpose of vaccination. The disclosed compounds have lipophilic moieties linked to the ring nitrogens. In addition, at least one of the ring nitrogens is quatranized and linked to a hydrocarbon having at least one heteroatom.Type: GrantFiled: December 23, 1998Date of Patent: February 8, 2000Assignee: Vical IncorporatedInventor: Carl J. Wheeler
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Patent number: 6013240Abstract: Compositions containing one or more nucleic acids and cationic polymers, and their use in gene therapy, particularly for in vivo nucleic acid transfer.Type: GrantFiled: February 28, 1997Date of Patent: January 11, 2000Assignee: Rhone-Poulenc Rorer SAInventors: Jean-Paul Behr, Barbara Demeneix, Franck Lezoualch, Mojgan Mergny, Daniel Scherman, Otmane Boussif
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Patent number: 6011020Abstract: This invention discloses a method for preparing a therapeutic or diagnostic complex comprised of a nucleic acid ligand and a lipophilic compound or non-immunogenic, high molecular weight compound by identifying a nucleic acid ligand by SELEX methodology and associating the nucleic acid ligand with a lipophilic compound or a non-immunogenic, high molecular weight compound. The invention further discloses complexes comprising one or more nucleic acid ligands in association with a lipophilic compound or non-immunogenic, high molecular weight compound.Type: GrantFiled: May 4, 1995Date of Patent: January 4, 2000Assignee: NeXstar Pharmaceuticals, Inc.Inventors: Larry Gold, Paul G. Schmidt, Nebojsa Janjic
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Patent number: 5993851Abstract: A biphasic multilamellar lipid vesicle comprising a plurality of spaced apart lipid bilayers that include a liposome-forming component and optionally a biologically active agent entrapped within the lipid bilayers. The lipid vesicle also comprises peripheral aqueous solution compartments formed between the lipid bilayers and a central lipophilic core compartment substantially at the center of the multilamellar lipid vesicle.Type: GrantFiled: March 13, 1998Date of Patent: November 30, 1999Assignee: PharmaDerm Laboratories, Ltd.Inventor: Marianna Foldvari
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Patent number: 5994317Abstract: Cationic lipids, having a derivatized quaternary ammonium head group, that provide improved cell targeting ability and enhanced transfective efficacy for the delivery of molecules into cells. The lipids comprise a linker having functional groups that provide sites for further attachment of drugs, cell receptor ligands or other bioactive agents.Type: GrantFiled: April 9, 1996Date of Patent: November 30, 1999Assignee: Vical IncorporatedInventor: Carl J. Wheeler
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Patent number: 5994318Abstract: The instant disclosure relates to cochleates comprising a) a biologically relevant molecule component b) a negatively charged lipid component, and c) a divalent cation component. The cochleate has an extended shelf life, even in a desiccated state. Advantageously, the cochleate can be ingested. The biologically relevant molecule can be a topical application and an in vitro treatment, a polypeptide a drug, a nutrient, or a flavor.Type: GrantFiled: February 21, 1997Date of Patent: November 30, 1999Assignees: Albany Medical College, University of Medicine and Dentistry of New JerseyInventors: Susan Gould-Fogerite, Raphael James Mannino
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Patent number: 5972380Abstract: Described are reversibly N-acylated phosphotidylserine and phosphatidylethanolamine derivatives which are useful as caged aminophospholipids. Also described are pharmaceutical preparations containing pH-sensitive liposomes formed with the caged aminophospholipids, and related methods.Type: GrantFiled: June 16, 1998Date of Patent: October 26, 1999Assignee: Indiana University FoundationInventor: David L. Daleke
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Patent number: 5958371Abstract: A method for ligand-based binding of lipid encapsulated particles to molecular epitopes on a surface in vivo or in vitro comprises sequentially administering (a) a site-specific ligand activated with a biotin activating agent; (b) an avidin activating agent; and (c) lipid encapsulated particles activated with a biotin activating agent, whereby the ligand is conjugated to the particles through an avidin-biotin interaction and the resulting conjugate is bound to the molecular epitopes on such surface. The conjugate is effective for imaging by x-ray, ultrasound, magnetic resonance, positron emission tomography or nuclear imaging. Compositions for use in ultrasonic imaging of natural or synthetic surfaces and for enhancing the acoustic reflectivity thereof are also disclosed.Type: GrantFiled: December 12, 1997Date of Patent: September 28, 1999Assignee: Barnes-Jewish HospitalInventors: Gregory M. Lanza, Samuel A. Wickline
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Patent number: 5942209Abstract: Locally deposited polymer depots are used as a vehicle for the immobilization and local delivery of a radionuclide or radiopharmaceutical. Radionuclides are incorporated in their elemental forms, as inorganic compounds, or are attached to a larger molecule or incorporated into the polymer, by physical or chemical methods. Ancillary structure may be employed to control the rate of release. Standard radionuclides which have been used for local radiotherapy may be used, such as radionuclides of iodine, iridium, radium, cesium, yttrium or other elements.Type: GrantFiled: November 3, 1997Date of Patent: August 24, 1999Assignee: Focal, Inc.Inventors: Richard D. Leavitt, Luis Z. Avila
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Patent number: 5935599Abstract: Novel polymer-associated liposomes (PALs) containing a liposome, and a polymer having a plurality of acid moieties, like sulfonic acid moieties, carboxyl moieties, or phosphonic acid moieties, in a salt form are disclosed. Drug compositions containing a PAL and a drug are administered to individuals suffering from a disease, and the drug is released, in vivo, to treat the disease, and to reduce, eliminate, or reverse complications associated with the disease.Type: GrantFiled: October 27, 1997Date of Patent: August 10, 1999Assignee: The Board of Trustees of the University of IllinoisInventor: Eric J. Dadey
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Patent number: 5888473Abstract: Boron neutron capture therapy can utilize X.sub.y B.sub.20 H.sub.17 L where X is an alkali metal, y is 1 to 4, and L is a two electron donor such as NH.sub.3, and Na.sub.2 B.sub.10 H.sub.9 NCO, among others. These borane salts may be used free or encapsulated in liposomes. Liposomes may have embedded within their bilayers carboranes to increase the amount of delivered .sup.10 B and/or to increase the tumor specificity of the liposome.Type: GrantFiled: August 3, 1995Date of Patent: March 30, 1999Assignee: The Regents of the University of CaliforniaInventors: M. Frederick Hawthorne, Debra Arliene Feakes, Kenneth John Shelly
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Patent number: 5869091Abstract: The invention provides an aqueous formulation comprising a pharmaceutically active agent present within vesicles suspended in an aqueous carrier. The invention resides in the finding that improved therapeutic efficacy can be achieved by providing the active agent both in the vesicles themselves and in the aqueous carrier vehicle. The invention provides a formulation which comprises: an aqueous vehicle; vesicles suspended in the aqueous vehicle; and a pharmaceutically active agent comprised within both the vesicles and the aqueous vehicle.Type: GrantFiled: February 26, 1997Date of Patent: February 9, 1999Assignee: University of StrathclydeInventors: Katharine Christine Carter, Alan James Baillie, Denise Margaret Williams
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Patent number: 5861397Abstract: The present invention relates to piperazine based amphilic cationic lipids useful for gene therapy, transfection, and introducing immunogenic compounds for the purpose of vaccination. The disclosed compounds have lipophilic moieties linked to the ring nitrogens. In addition, at least one of the ring nitrogens is quatranized and linked to a hydrocarbon having at least one heteroatom.Type: GrantFiled: October 3, 1996Date of Patent: January 19, 1999Assignee: Vical IncorporatedInventor: Carl J. Wheeler
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Patent number: 5853752Abstract: Methods of and apparatus for preparing temperature activated gaseous precursor-filled liposomes are described. Gaseous precursor-filled liposomes prepared by these methods are particularly useful, for example, in ultrasonic imaging applications and in therapeutic drug delivery systems.Type: GrantFiled: June 6, 1995Date of Patent: December 29, 1998Assignee: ImaRx Pharmaceutical Corp.Inventors: Evan C. Unger, Thomas A. Fritz, Terry Matsunaga, VaradaRajan Ramaswami, David Yellowhair, Guanli Wu
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Patent number: 5853694Abstract: The invention relates to new compounds with the general formula I for use as a tool to introduce macromolecules into cells. The invention further relates to compositions for introducing macromolecules into cells, comprising vesicles formed by at least one compound in a solvent. The macromolecule can be incorporated in the vesicles and/or bound to the vesicles or another aggregate of the new compounds. In a preferred embodiment at least one targeting molecule, for instance a (labelled) antibody, may further be attached to the vesicles.Type: GrantFiled: July 24, 1996Date of Patent: December 29, 1998Assignees: Stitching Voor DeTechnische Wetenschappen, Rijksuniversiteit Groningen, Stichting Scheikundig Ondoerzoek in NederlandInventors: Jan Bernard Frederik Nicolaas Engberts, Anno Wagenaar, Dirk Hoekstra, Irene Van Der Woude, Marcel Herman Jozef Ruiters
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Patent number: 5853755Abstract: A biphasic multilamellar lipid vesicle comprising a plurality of spaced apart lipid bilayers that include a liposome-forming component and optionally a biologically active agent entrapped within the lipid bilayers. The lipid vesicle also comprises peripheral aqueous solution compartments formed between the lipid bilayers and a central lipophilic core compartment substantially at the center of the multilamellar lipid vesicle.Type: GrantFiled: June 10, 1997Date of Patent: December 29, 1998Assignee: PharmaDerm Laboratories Ltd.Inventor: Marianna Foldvari
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Patent number: 5846561Abstract: Recognizing substances, including epidermal growth factor, gelatin, collagen and hyaluronic acid, have been covalently bound to liposomal surfaces and utilized to attach liposomes onto a cellular or an extracellular matrix (ECM) target site. These "bioadhesive" liposomes offer several advantages including the mutual protection of both the drug and biological environment; an increase in drug bioavailability and retention at the target site; and improved adherence or adhesion to the designated target site.Type: GrantFiled: December 10, 1996Date of Patent: December 8, 1998Assignee: Baxter International Inc.Inventor: Rimona Margalit
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Patent number: 5834439Abstract: The present invention discloses highly packed polycationic ammonium, sulfonium and phosphonium lipid compounds useful for making lipid aggregates for delivery of macromolecules and other compounds into cells. They are especially useful for the DNA-dependent transformation of cells. Methods for their preparation and use as intracellular delivery agents are also disclosed.Type: GrantFiled: January 13, 1997Date of Patent: November 10, 1998Assignee: Life Technologies, Inc.Inventors: Alberto Haces, Valentina C. Ciccarone
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Patent number: 5830499Abstract: Phospholipid- and cholesterol-free aqueous compositions for topical application to the skin contain a pharmaceutically active ingredient and a vector system of controlled and in-depth transport and release of the active ingredient through the skin. The vector system comprises at least one first non-ionic surfactant which forms vesicles upon dispersion in water and a lamellar phase upon concentrating the vesicles, and at least one second non-ionic hydrophilic surfactant. The ratios of the two non-ionic surfactants are such that the vector system comprises flexible vesicles.Type: GrantFiled: May 28, 1997Date of Patent: November 3, 1998Assignee: Rijksuniversiteit LeidenInventor: Johanna Aaltje Bouwstra
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Patent number: 5830430Abstract: Cationic lipid compounds which comprise at least two cationic groups. The cationic lipid compounds are particularly suitable for use as carriers in the intracellular delivery of bioactive agents, including pharmaceuticals and genetic material. Compositions of the present cationic lipid compounds include suspensions, emulsions, micelles and liposomes.Type: GrantFiled: February 21, 1995Date of Patent: November 3, 1998Assignee: ImaRx Pharmaceutical Corp.Inventors: Evan C. Unger, Dekang Shen, Guanli Wu
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Patent number: 5827533Abstract: Liposomes contain active agents which are aggregated with a lipid surfactant. The composition of the liposome membrane stabilizes the membrane against the disruptive effects of the active agent-surfactant aggregate contained therein.Type: GrantFiled: February 6, 1997Date of Patent: October 27, 1998Assignee: Duke UniversityInventor: David Needham
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Patent number: 5820873Abstract: The present invention provides a novel class of polyethylene glycol modified ceramide lipids. The lipids can be used to form liposomes optionally containing various biological agents or drugs, such as anti-cancer agents. In addition, methods of use for the liposomes are provided.Type: GrantFiled: June 7, 1995Date of Patent: October 13, 1998Assignee: The University of British ColumbiaInventors: Lewis S. L. Choi, Thomas D. Madden, Murray S. Webb
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Patent number: 5820879Abstract: A method of delivering a therapeutic compound to an in vivo target site having a selected pH, temperature, ligand concentration or binding-molecule characteristic. The method includes entrapping the therapeutic compound in an encapsulated microparticle composition that, when exposed to a selected target stimulus related to pH, temperature, radiation, or the presence of a selected ligand or ion-channel activator, decondenses to release compound into the target site. The encapsulated microparticle composition consists of a condensed-phase particle matrix containing the compound to be delivered in entrapped form, and a stimulus-responsive lipid bilayer membrane formed around the matrix. Localized perturbation of the lipid membrane, and influx of monovalent counterions into the polymer matrix, in response to the selected target stimulus, causes matrix swelling and compound release from the particles.Type: GrantFiled: May 18, 1995Date of Patent: October 13, 1998Assignee: ACCESS Pharmaceuticals, Inc.Inventors: Julio M. Fernandez, Mark B. Knudson
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Patent number: 5820848Abstract: This invention provides a composition containing a sized liposome comprising a lipid and an induce; the sized liposome has a diameter of at most about 1 micoron and the induces is present in an amount effective to induce interdigitation-fusion of the sized liposome. Also provided herein are interdigitation-fusion liposomes and gels, and methods of making the same.Type: GrantFiled: September 30, 1994Date of Patent: October 13, 1998Assignee: The Liposome Company, Inc.Inventors: Lawrence T. Boni, Andrew S. Janoff, Sharma R. Minchey, Walter R. Perkins, Christine E. Swenson, Patrick L. Ahl, Thomas S. Davis
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Patent number: 5770222Abstract: Therapeutic drug delivery systems comprising gas-filled microspheres comprising a therapeutic are described. Methods for employing such microspheres in therapeutic drug delivery applications are also provided. Drug delivery systems comprising gas-filled liposomes having encapsulated therein a drug are preferred. Methods of and apparatus for preparing such liposomes and methods for employing such liposomes in drug delivery applications are also disclosed.Type: GrantFiled: June 7, 1995Date of Patent: June 23, 1998Assignee: ImaRx Pharmaceutical Corp.Inventors: Evan C. Unger, Thomas A. Fritz, Terry Matsunaga, VaradaRajan Ramaswami, David Yellowhair, Guanli Wu
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Patent number: 5766627Abstract: A multivesicular liposome composition containing at least one acid other than a hydrohalic acid and at least one biologically active substance, the vesicles having defined size distribution, adjustable average size, internal chamber size and number, provides a controlled release rate of the biologically active substance from the composition. A process for making the composition features addition of a non-hydrohalic acid effective to sustain and control the rate of release of an encapsulated biologically active substance from the vesicles at therapeutic levels in vivo.Type: GrantFiled: May 23, 1997Date of Patent: June 16, 1998Assignee: DepotechInventors: Mantripragada Bhima Sankaram, Sinil Kim
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Patent number: 5762904Abstract: Polymerized liposomes, methods of preparing the polymerized liposomes and incorporating biologically active substances within the polymerized liposomes, and methods of administering polymerized liposomes containing a biologically active substance to be delivered to a patient are disclosed. The polymerized liposomes are prepared by polymerizing double bond-containing liposomes. The polymerization can be initiated with a source of radiation and/or a free radical initiator. Biologically active substances can be incorporated into both the hydrophilic and hydrophobic layers of the liposomes, either during or after polymerization. The polymerized liposomes can be administered orally to a patient in need of the biologically active substance to be delivered. Examples demonstrate enhanced stability.Type: GrantFiled: January 17, 1997Date of Patent: June 9, 1998Assignee: Massachusetts Institute of TechnologyInventors: Junichi Okada, Smadar Cohen, Robert S. Langer
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Patent number: 5738868Abstract: A method for preparing a radio labelled liposome, the method including the steps of at least once dehydrating and rehydrating a treated liposome to form a binding liposome, and adding a radio label to said binding liposome to form the radio labelled liposome.Type: GrantFiled: July 18, 1995Date of Patent: April 14, 1998Assignee: Lipogenics Ltd.Inventor: Leonid Lurya Shinkarenko