Over 60 To 62% Carbon Patents (Class 424/121)
  • Patent number: 10499665
    Abstract: A complete ration, or diet, suitable for beef cattle in different fattening stages is provided, as well as a method for formulating the ration. All by-products of sugar manufacture are recycled and used to formulate the complete ration for beef cattle in different fattening stages, using sugarcane tip leaves and alkalized bagasse as raw materials, using molasses and corn flour as energy feed, using peanut bran, soybean residual, rapeseed meal, etc., as protein feed, using carbamide, dicalcium phosphate, limestone powder, bacteria strain and pre-mixture as other additives. The complete ration suitable for beef cattle in each growing stages can be flexibly formulated according to nutrients requirements of beef cattle in different growing stages. Comparing to the regular feed for the same fattening stage, the complete ration described can lead to a lower production cost and a lower ratio between feed and weight, and bring higher economic values.
    Type: Grant
    Filed: November 9, 2017
    Date of Patent: December 10, 2019
    Assignees: GUANGDONG PROVINCIAL BIOENGINEERING INSTITUTE (GUANGZHOU SUGARCANE INDUSTRY RESEARCH INSTITUTE), GUANGXI STATE FARMS JINGUANG DAIRY INDUSTRY CO., LTD.
    Inventors: Wenxing Tan, Ximiao Yi, Jiazhou Wei, Dafeng Liang, Hongqiao Wei, Bu Ma, Zengwei Huang, Zhijian Wei, Zhaopeng Wu, Guowei Chang, Yu Zhang
  • Patent number: 9913858
    Abstract: The invention described in this specification relates to the prevention and treatment of alkaloid-induced toxicosis in pasture grazing animals.
    Type: Grant
    Filed: November 20, 2014
    Date of Patent: March 13, 2018
    Assignees: MEAT & LIVESTOCK AUSTRALIA LIMITED, CHARLES STURT UNIVERSITY
    Inventors: Jane Quinn, Scott Edwards, Martin Combs
  • Patent number: 7652265
    Abstract: An air treatment system includes a housing defining a chamber, and an ultraviolet lamp positioned within the chamber. The housing further defines an air inlet at a first end portion of the housing and an air outlet at a second end portion of the housing opposing the first end portion. The chamber provides flow communication between the air inlet and the air outlet. At least one ultraviolet lamp is positioned within the chamber. The at least one ultraviolet lamp is positioned about a first axis and includes a first end and a second end spaced with respect to the first end along the first axis. The at least one ultraviolet lamp is configured for facilitating inactivating contaminants within air channeled through the chamber.
    Type: Grant
    Filed: December 11, 2006
    Date of Patent: January 26, 2010
    Assignee: General Electric Company
    Inventors: Gautam Subbarao, Mark Wayne Wilson, Anand Ganesh Joshi, Hemachandran Umakanthan, Ramnath Vaidyanathan
  • Patent number: 6855524
    Abstract: The invention concerns a method for producing exopolysaccharides by fermenting micro-organisms characterised in that it consists in carrying out the fermentation in a nutrient medium comprising at least a source of carbon available to the micro-organisms and at least a source of nitrogen, said source being derived from a fraction of carob seed.
    Type: Grant
    Filed: September 6, 2000
    Date of Patent: February 15, 2005
    Assignee: Danisco USA Inc.
    Inventors: Olivier Nore, Jean-Luc Simon
  • Patent number: 6482082
    Abstract: In a heating and/or air-conditioning system especially for an automobile with a blower housing and a distributor housing located in front of and below an instrument panel, provision is made such that the distributor housing can be separated toward the vehicle interior from the blower housing. The distributor housing has a front end facing the vehicle interior which fills a recess in the instrument panel provided for removing the distributor housing.
    Type: Grant
    Filed: November 23, 1998
    Date of Patent: November 19, 2002
    Assignee: Behr GmbH & Co.
    Inventors: Martin Derleth, Klaus Luz, Adem Hizli, Markus Schmid, Martin Stemmler, Walter Wolf
  • Patent number: 6306629
    Abstract: The present invention is related to a new microorganism Streptomyces exfoliatus YJ-118 and a method for producing pravastatin sodium by using this microorganism which shows a strong tolerance to ML-236B and a high hydroxylation activity of ML-236B to pravastatin.
    Type: Grant
    Filed: December 29, 1999
    Date of Patent: October 23, 2001
    Assignee: Yungjin Pharmaceutical Ind. Co., Ltd.
    Inventors: Joo-Kyung Lee, Joo-Woong Park, Dong-Jin Seo, Sang-Choon Lee, Ji-Yoon Kim
  • Patent number: 6207186
    Abstract: The invention provides novel compositions involving lamellar gels and methods for making them. These compositions and methods of the invention are significant improvements in the field of gels, macromolecular targeting and macromolecular delivery to various biological systems.
    Type: Grant
    Filed: February 13, 1998
    Date of Patent: March 27, 2001
    Assignee: The Regents of the University of California
    Inventors: Cyrus R. Safinya, Heidi E. Warriner, Stefan H. J. Idziak
  • Patent number: 6171612
    Abstract: Lipopolyamines useful for the transfection of nucleic acid and methods of preparation thereof are disclosed. The lipopolyamines are of general formula I, in which R4 comprises at least one C10-C22 aliphatic radical.
    Type: Grant
    Filed: May 13, 1998
    Date of Patent: January 9, 2001
    Assignee: Aventis Pharma S.A.
    Inventors: G{acute over (e)}rardo Byk, Daniel Scherman, Bertrand Schwartz, Catherine Dubertret
  • Patent number: 6165441
    Abstract: A method of therapeutical treatment of tumors, by photodynamic therapy comprising administering to a subject in need of said treatment an effective amount of a tumor-localizing photosensitizer consisting of a metal phthalocyanine, together with a minor amount of a tracer consisting of said metal phthalocyanine labelled with a radioactive isotope and non-invasively monitoring the concentration of said tracer in the target tumoral tissue and in the peritumoral tissue, thereby to identify the appropriate post-administration interval for performing the photodynamic therapy.
    Type: Grant
    Filed: August 24, 1995
    Date of Patent: December 26, 2000
    Assignee: Nycomed Amersham Sorin SRL
    Inventors: Rodolfo Franceschini, Giulio Iori, Laura Polo, Giovanni Bocchiotti
  • Patent number: 6149937
    Abstract: A process for the entrapment of amphiphilic compounds as uncharged or ionic with different mole ratios of phospholipid to the amphiphilic compound. Preparations of ionic species of amphiphilic compounds in the absence of crystals can be prepared, while preparations of uncharged amphiphilic compounds can be prepared with the compound exclusively entrapped inside the liposomes, or partly entrapped inside the liposomes with extraliposomal crystals.
    Type: Grant
    Filed: November 19, 1998
    Date of Patent: November 21, 2000
    Assignee: Vrije Universiteit Brussel
    Inventors: Frederic Camu, Mokarram Alafandy, Robert Brasseur, Franz Legros, Oliver Bouffioux
  • Patent number: 6143321
    Abstract: Liposomes formulations are designed to maximize the amount of poorly water-soluble active agent that can be carried by the liposome. Liposomes containing active agent in the lipid bilayer of the liposome, and/or entrapped within the liposome interior space in a micellar preparation are described. Methods of making such liposomes are presented.
    Type: Grant
    Filed: October 19, 1998
    Date of Patent: November 7, 2000
    Assignee: Duke University
    Inventors: David Needham, Ranjit S. Sarpal
  • Patent number: 6143729
    Abstract: Novel amidinium derivatives of formula (I), wherein R1 is a cholesterol derivative or an alkylamino-NR'R" grouping, and each of R2 and R3 is independently a hydrogen atom or a grouping of formula (II), wherein each of R4 and R5 is independently a hydrogen atom or a grouping of formula (III), are disclosed. The corresponding pharmaceutical compositions, which are particularly useful in gene therapy for transferring therapeutic genes into cells, are also disclosed.
    Type: Grant
    Filed: September 11, 1998
    Date of Patent: November 7, 2000
    Assignee: Aventis Pharma S.A.
    Inventors: Jean-Marie Lehn, Pierre Lehn, Jean-Pierre Vigneron
  • Patent number: 6132764
    Abstract: Polymerized liposome particles which are linked to a targeting agent and may also be linked to a contrast enhancement agent and/or linked to or encapsulating a treatment agent. The targeting imaging enhancement polymerized liposome particles interact with biological targets holding the image enhancement agent to specific sites providing in vitro and in vivo study by magnetic resonance, radioactive, x-ray or optical imaging of the expression of molecules in cells and tissues during disease and pathology. Targeting polymerized liposomes may be linked to or encapsulate a treatment agent, such as, proteins, drugs or hormones for directed delivery to specific biological sites for treatment.
    Type: Grant
    Filed: April 8, 1996
    Date of Patent: October 17, 2000
    Assignee: Targesome, Inc.
    Inventors: King Chuen Li, Mark David Bednarski, Richard Wood Storrs, Henry Y. Li, Francois Daniel Tropper, Curtis Kang Hoon Song, Dorothy Anna Sipkins, Jeremy Kenji Kuniyoshi
  • Patent number: 6120795
    Abstract: A method for preparing liposomal suspensions which comprises preparing a solution of a poorly soluble protein or other poorly soluble compound and an encapsulating amount of a suitable lipid in an alcoholic solvent, injecting the resulting solution into an aqueous solution of appropriate ionic strength, and removing the alcoholic solvent by thin-film evaporation at the transition temperature of the liposomal suspension. This process is suitable for continuous production on an industrial manufacturing scale. It is of particular application in the preparation of KL4 pulmonary surfactant composition, wherein the thin film evaporation is conducted within the transition temperature range of the surfactant (approximately 35-50.degree. C.), thereby enhancing the KL4 peptide insertion into the lipid bilayer and leading to a product with reduced viscosity and enhanced surface tension lowering properties.
    Type: Grant
    Filed: March 4, 1997
    Date of Patent: September 19, 2000
    Assignee: Ortho Pharmaceutical Corp.
    Inventors: Robert Joseph Klimchak, Peter G. Glavinos, Jr., deceased
  • Patent number: 6117852
    Abstract: The present invention discloses a boron-containing pharmaceutical composition useful in boron neutron capture therapy of hepatoma, which includes lipiodol, stibmicron boron powder, lecithin and unsaturated fatty acid. The lipiodol has a property of a high retention in hepatoma, the lecithin has a boron carrying capacity, and the unsaturated fatty acid has a function of rendering lecithin soluble in lipiodol.
    Type: Grant
    Filed: December 29, 1997
    Date of Patent: September 12, 2000
    Assignee: National Science Council
    Inventor: Fong-In Chou
  • Patent number: 6110916
    Abstract: The present invention discloses highly packed polycationic ammonium, sulfonium and phosphonium lipid compounds useful for making lipid aggregates for delivery of macromolecules and other compounds into cells. They are especially useful for the DNA-dependent transformation of cells. Methods for their preparation and use as intracellular delivery agents are also disclosed.
    Type: Grant
    Filed: November 6, 1998
    Date of Patent: August 29, 2000
    Assignee: Life Technologies, Inc.
    Inventors: Alberto Haces, Valentina C. Ciccarone
  • Patent number: 6106859
    Abstract: The present invention provides a liposomal aerosol composition, comprising a pharmaceutical compound, a cationic lipid, (c) a neutral co-lipid; and (d) tryptone. Also provided is a nebulized cationic lipid:DNA suspension useful for lipid-DNA transfections, wherein said cationic lipid is bis(guanidinium)-tren-cholesterol.
    Type: Grant
    Filed: January 8, 1999
    Date of Patent: August 22, 2000
    Inventors: Charles L. Densmore, Jr., J. Vernon Knight, J. Clifford Waldrep, Berma M. Kinsey
  • Patent number: 6103217
    Abstract: The presently claimed invention relates to polymeric assemblies which visibly change color in the presence of analyte. In particular, the presently claimed invention relates to liposomes comprising a plurality of lipid monomers, which comprises a polymerizable group, a hydrophilic head group and a hydrophobic tail group, and one or more ligands. Overall carbon chain length, and polymerizable group positioning on the monomer influence color change sensitivity to analyte concentrations.
    Type: Grant
    Filed: July 28, 1997
    Date of Patent: August 15, 2000
    Assignee: The Regents of the University of California
    Inventor: Deborah Charych
  • Patent number: 6063400
    Abstract: This invention provides a liposomal construct for delivering a diagnostic or therapeutic agent to a mammal comprising a liposomal carrier, a diagnostic or therapeutic agent entrapped within or associated with said liposomal carrier and a sequestering agent distributed within said liposomal carrier to reduce leakage of the diagnostic or therapeutic agent from the liposomal construct prior to delivery.
    Type: Grant
    Filed: July 2, 1998
    Date of Patent: May 16, 2000
    Assignee: SDG, Inc.
    Inventors: W. Blair Geho, John R. Lau
  • Patent number: 6056938
    Abstract: Cationic lipid compounds which comprise at least two cationic groups. The cationic lipid compounds are particularly suitable for use as carriers in the intracellular delivery of bioactive agents, including pharmaceuticals and genetic material. Compositions of the present cationic lipid compounds include suspensions, emulsions, micelles and liposomes.
    Type: Grant
    Filed: May 5, 1998
    Date of Patent: May 2, 2000
    Assignee: Imarx Pharaceutical Corp.
    Inventors: Evan C. Unger, Dekang Shen, Guanli Wu
  • Patent number: 6048545
    Abstract: Substances, such as pharmaceuticals and cosmetics, are administered encapsulated within a lipid vesicle, by iontophoresis. An iontophoretic device which conforms to the contours of the body is also provided.
    Type: Grant
    Filed: July 22, 1996
    Date of Patent: April 11, 2000
    Assignee: BioZone Laboratories, Inc.
    Inventors: Brian C. Keller, Daniel L. Fisher, Stefan Kiss, Michael Mezei
  • Patent number: 6045821
    Abstract: The present invention relates to a liposomal agent comprising liposomes having bound to a membrane thereof a chelated diagnostically or therapeutically effective metal ion. The chelating agent binding the metal ion has a macrocyclic chelant moiety with, attached to a single ring atom thereof, a lipophilic membrane associating moiety.
    Type: Grant
    Filed: May 29, 1997
    Date of Patent: April 4, 2000
    Assignee: Nycomed Salutar, Inc.
    Inventors: Martha Garrity, John Varadarajan, Alan David Watson
  • Patent number: 6022874
    Abstract: The present invention relates to piperazine based amphilic cationic lipids useful for gene therapy, transfection, and introducing immunogenic compounds for the purpose of vaccination. The disclosed compounds have lipophilic moieties linked to the ring nitrogens. In addition, at least one of the ring nitrogens is quatranized and linked to a hydrocarbon having at least one heteroatom.
    Type: Grant
    Filed: December 23, 1998
    Date of Patent: February 8, 2000
    Assignee: Vical Incorporated
    Inventor: Carl J. Wheeler
  • Patent number: 6013240
    Abstract: Compositions containing one or more nucleic acids and cationic polymers, and their use in gene therapy, particularly for in vivo nucleic acid transfer.
    Type: Grant
    Filed: February 28, 1997
    Date of Patent: January 11, 2000
    Assignee: Rhone-Poulenc Rorer SA
    Inventors: Jean-Paul Behr, Barbara Demeneix, Franck Lezoualch, Mojgan Mergny, Daniel Scherman, Otmane Boussif
  • Patent number: 6011020
    Abstract: This invention discloses a method for preparing a therapeutic or diagnostic complex comprised of a nucleic acid ligand and a lipophilic compound or non-immunogenic, high molecular weight compound by identifying a nucleic acid ligand by SELEX methodology and associating the nucleic acid ligand with a lipophilic compound or a non-immunogenic, high molecular weight compound. The invention further discloses complexes comprising one or more nucleic acid ligands in association with a lipophilic compound or non-immunogenic, high molecular weight compound.
    Type: Grant
    Filed: May 4, 1995
    Date of Patent: January 4, 2000
    Assignee: NeXstar Pharmaceuticals, Inc.
    Inventors: Larry Gold, Paul G. Schmidt, Nebojsa Janjic
  • Patent number: 5994318
    Abstract: The instant disclosure relates to cochleates comprising a) a biologically relevant molecule component b) a negatively charged lipid component, and c) a divalent cation component. The cochleate has an extended shelf life, even in a desiccated state. Advantageously, the cochleate can be ingested. The biologically relevant molecule can be a topical application and an in vitro treatment, a polypeptide a drug, a nutrient, or a flavor.
    Type: Grant
    Filed: February 21, 1997
    Date of Patent: November 30, 1999
    Assignees: Albany Medical College, University of Medicine and Dentistry of New Jersey
    Inventors: Susan Gould-Fogerite, Raphael James Mannino
  • Patent number: 5993851
    Abstract: A biphasic multilamellar lipid vesicle comprising a plurality of spaced apart lipid bilayers that include a liposome-forming component and optionally a biologically active agent entrapped within the lipid bilayers. The lipid vesicle also comprises peripheral aqueous solution compartments formed between the lipid bilayers and a central lipophilic core compartment substantially at the center of the multilamellar lipid vesicle.
    Type: Grant
    Filed: March 13, 1998
    Date of Patent: November 30, 1999
    Assignee: PharmaDerm Laboratories, Ltd.
    Inventor: Marianna Foldvari
  • Patent number: 5994317
    Abstract: Cationic lipids, having a derivatized quaternary ammonium head group, that provide improved cell targeting ability and enhanced transfective efficacy for the delivery of molecules into cells. The lipids comprise a linker having functional groups that provide sites for further attachment of drugs, cell receptor ligands or other bioactive agents.
    Type: Grant
    Filed: April 9, 1996
    Date of Patent: November 30, 1999
    Assignee: Vical Incorporated
    Inventor: Carl J. Wheeler
  • Patent number: 5972380
    Abstract: Described are reversibly N-acylated phosphotidylserine and phosphatidylethanolamine derivatives which are useful as caged aminophospholipids. Also described are pharmaceutical preparations containing pH-sensitive liposomes formed with the caged aminophospholipids, and related methods.
    Type: Grant
    Filed: June 16, 1998
    Date of Patent: October 26, 1999
    Assignee: Indiana University Foundation
    Inventor: David L. Daleke
  • Patent number: 5958371
    Abstract: A method for ligand-based binding of lipid encapsulated particles to molecular epitopes on a surface in vivo or in vitro comprises sequentially administering (a) a site-specific ligand activated with a biotin activating agent; (b) an avidin activating agent; and (c) lipid encapsulated particles activated with a biotin activating agent, whereby the ligand is conjugated to the particles through an avidin-biotin interaction and the resulting conjugate is bound to the molecular epitopes on such surface. The conjugate is effective for imaging by x-ray, ultrasound, magnetic resonance, positron emission tomography or nuclear imaging. Compositions for use in ultrasonic imaging of natural or synthetic surfaces and for enhancing the acoustic reflectivity thereof are also disclosed.
    Type: Grant
    Filed: December 12, 1997
    Date of Patent: September 28, 1999
    Assignee: Barnes-Jewish Hospital
    Inventors: Gregory M. Lanza, Samuel A. Wickline
  • Patent number: 5942209
    Abstract: Locally deposited polymer depots are used as a vehicle for the immobilization and local delivery of a radionuclide or radiopharmaceutical. Radionuclides are incorporated in their elemental forms, as inorganic compounds, or are attached to a larger molecule or incorporated into the polymer, by physical or chemical methods. Ancillary structure may be employed to control the rate of release. Standard radionuclides which have been used for local radiotherapy may be used, such as radionuclides of iodine, iridium, radium, cesium, yttrium or other elements.
    Type: Grant
    Filed: November 3, 1997
    Date of Patent: August 24, 1999
    Assignee: Focal, Inc.
    Inventors: Richard D. Leavitt, Luis Z. Avila
  • Patent number: 5935599
    Abstract: Novel polymer-associated liposomes (PALs) containing a liposome, and a polymer having a plurality of acid moieties, like sulfonic acid moieties, carboxyl moieties, or phosphonic acid moieties, in a salt form are disclosed. Drug compositions containing a PAL and a drug are administered to individuals suffering from a disease, and the drug is released, in vivo, to treat the disease, and to reduce, eliminate, or reverse complications associated with the disease.
    Type: Grant
    Filed: October 27, 1997
    Date of Patent: August 10, 1999
    Assignee: The Board of Trustees of the University of Illinois
    Inventor: Eric J. Dadey
  • Patent number: 5888473
    Abstract: Boron neutron capture therapy can utilize X.sub.y B.sub.20 H.sub.17 L where X is an alkali metal, y is 1 to 4, and L is a two electron donor such as NH.sub.3, and Na.sub.2 B.sub.10 H.sub.9 NCO, among others. These borane salts may be used free or encapsulated in liposomes. Liposomes may have embedded within their bilayers carboranes to increase the amount of delivered .sup.10 B and/or to increase the tumor specificity of the liposome.
    Type: Grant
    Filed: August 3, 1995
    Date of Patent: March 30, 1999
    Assignee: The Regents of the University of California
    Inventors: M. Frederick Hawthorne, Debra Arliene Feakes, Kenneth John Shelly
  • Patent number: 5869091
    Abstract: The invention provides an aqueous formulation comprising a pharmaceutically active agent present within vesicles suspended in an aqueous carrier. The invention resides in the finding that improved therapeutic efficacy can be achieved by providing the active agent both in the vesicles themselves and in the aqueous carrier vehicle. The invention provides a formulation which comprises: an aqueous vehicle; vesicles suspended in the aqueous vehicle; and a pharmaceutically active agent comprised within both the vesicles and the aqueous vehicle.
    Type: Grant
    Filed: February 26, 1997
    Date of Patent: February 9, 1999
    Assignee: University of Strathclyde
    Inventors: Katharine Christine Carter, Alan James Baillie, Denise Margaret Williams
  • Patent number: 5861397
    Abstract: The present invention relates to piperazine based amphilic cationic lipids useful for gene therapy, transfection, and introducing immunogenic compounds for the purpose of vaccination. The disclosed compounds have lipophilic moieties linked to the ring nitrogens. In addition, at least one of the ring nitrogens is quatranized and linked to a hydrocarbon having at least one heteroatom.
    Type: Grant
    Filed: October 3, 1996
    Date of Patent: January 19, 1999
    Assignee: Vical Incorporated
    Inventor: Carl J. Wheeler
  • Patent number: 5853752
    Abstract: Methods of and apparatus for preparing temperature activated gaseous precursor-filled liposomes are described. Gaseous precursor-filled liposomes prepared by these methods are particularly useful, for example, in ultrasonic imaging applications and in therapeutic drug delivery systems.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: December 29, 1998
    Assignee: ImaRx Pharmaceutical Corp.
    Inventors: Evan C. Unger, Thomas A. Fritz, Terry Matsunaga, VaradaRajan Ramaswami, David Yellowhair, Guanli Wu
  • Patent number: 5853755
    Abstract: A biphasic multilamellar lipid vesicle comprising a plurality of spaced apart lipid bilayers that include a liposome-forming component and optionally a biologically active agent entrapped within the lipid bilayers. The lipid vesicle also comprises peripheral aqueous solution compartments formed between the lipid bilayers and a central lipophilic core compartment substantially at the center of the multilamellar lipid vesicle.
    Type: Grant
    Filed: June 10, 1997
    Date of Patent: December 29, 1998
    Assignee: PharmaDerm Laboratories Ltd.
    Inventor: Marianna Foldvari
  • Patent number: 5853694
    Abstract: The invention relates to new compounds with the general formula I for use as a tool to introduce macromolecules into cells. The invention further relates to compositions for introducing macromolecules into cells, comprising vesicles formed by at least one compound in a solvent. The macromolecule can be incorporated in the vesicles and/or bound to the vesicles or another aggregate of the new compounds. In a preferred embodiment at least one targeting molecule, for instance a (labelled) antibody, may further be attached to the vesicles.
    Type: Grant
    Filed: July 24, 1996
    Date of Patent: December 29, 1998
    Assignees: Stitching Voor DeTechnische Wetenschappen, Rijksuniversiteit Groningen, Stichting Scheikundig Ondoerzoek in Nederland
    Inventors: Jan Bernard Frederik Nicolaas Engberts, Anno Wagenaar, Dirk Hoekstra, Irene Van Der Woude, Marcel Herman Jozef Ruiters
  • Patent number: 5846561
    Abstract: Recognizing substances, including epidermal growth factor, gelatin, collagen and hyaluronic acid, have been covalently bound to liposomal surfaces and utilized to attach liposomes onto a cellular or an extracellular matrix (ECM) target site. These "bioadhesive" liposomes offer several advantages including the mutual protection of both the drug and biological environment; an increase in drug bioavailability and retention at the target site; and improved adherence or adhesion to the designated target site.
    Type: Grant
    Filed: December 10, 1996
    Date of Patent: December 8, 1998
    Assignee: Baxter International Inc.
    Inventor: Rimona Margalit
  • Patent number: 5834439
    Abstract: The present invention discloses highly packed polycationic ammonium, sulfonium and phosphonium lipid compounds useful for making lipid aggregates for delivery of macromolecules and other compounds into cells. They are especially useful for the DNA-dependent transformation of cells. Methods for their preparation and use as intracellular delivery agents are also disclosed.
    Type: Grant
    Filed: January 13, 1997
    Date of Patent: November 10, 1998
    Assignee: Life Technologies, Inc.
    Inventors: Alberto Haces, Valentina C. Ciccarone
  • Patent number: 5830499
    Abstract: Phospholipid- and cholesterol-free aqueous compositions for topical application to the skin contain a pharmaceutically active ingredient and a vector system of controlled and in-depth transport and release of the active ingredient through the skin. The vector system comprises at least one first non-ionic surfactant which forms vesicles upon dispersion in water and a lamellar phase upon concentrating the vesicles, and at least one second non-ionic hydrophilic surfactant. The ratios of the two non-ionic surfactants are such that the vector system comprises flexible vesicles.
    Type: Grant
    Filed: May 28, 1997
    Date of Patent: November 3, 1998
    Assignee: Rijksuniversiteit Leiden
    Inventor: Johanna Aaltje Bouwstra
  • Patent number: 5830430
    Abstract: Cationic lipid compounds which comprise at least two cationic groups. The cationic lipid compounds are particularly suitable for use as carriers in the intracellular delivery of bioactive agents, including pharmaceuticals and genetic material. Compositions of the present cationic lipid compounds include suspensions, emulsions, micelles and liposomes.
    Type: Grant
    Filed: February 21, 1995
    Date of Patent: November 3, 1998
    Assignee: ImaRx Pharmaceutical Corp.
    Inventors: Evan C. Unger, Dekang Shen, Guanli Wu
  • Patent number: 5827533
    Abstract: Liposomes contain active agents which are aggregated with a lipid surfactant. The composition of the liposome membrane stabilizes the membrane against the disruptive effects of the active agent-surfactant aggregate contained therein.
    Type: Grant
    Filed: February 6, 1997
    Date of Patent: October 27, 1998
    Assignee: Duke University
    Inventor: David Needham
  • Patent number: 5820879
    Abstract: A method of delivering a therapeutic compound to an in vivo target site having a selected pH, temperature, ligand concentration or binding-molecule characteristic. The method includes entrapping the therapeutic compound in an encapsulated microparticle composition that, when exposed to a selected target stimulus related to pH, temperature, radiation, or the presence of a selected ligand or ion-channel activator, decondenses to release compound into the target site. The encapsulated microparticle composition consists of a condensed-phase particle matrix containing the compound to be delivered in entrapped form, and a stimulus-responsive lipid bilayer membrane formed around the matrix. Localized perturbation of the lipid membrane, and influx of monovalent counterions into the polymer matrix, in response to the selected target stimulus, causes matrix swelling and compound release from the particles.
    Type: Grant
    Filed: May 18, 1995
    Date of Patent: October 13, 1998
    Assignee: ACCESS Pharmaceuticals, Inc.
    Inventors: Julio M. Fernandez, Mark B. Knudson
  • Patent number: 5820873
    Abstract: The present invention provides a novel class of polyethylene glycol modified ceramide lipids. The lipids can be used to form liposomes optionally containing various biological agents or drugs, such as anti-cancer agents. In addition, methods of use for the liposomes are provided.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: October 13, 1998
    Assignee: The University of British Columbia
    Inventors: Lewis S. L. Choi, Thomas D. Madden, Murray S. Webb
  • Patent number: 5820848
    Abstract: This invention provides a composition containing a sized liposome comprising a lipid and an induce; the sized liposome has a diameter of at most about 1 micoron and the induces is present in an amount effective to induce interdigitation-fusion of the sized liposome. Also provided herein are interdigitation-fusion liposomes and gels, and methods of making the same.
    Type: Grant
    Filed: September 30, 1994
    Date of Patent: October 13, 1998
    Assignee: The Liposome Company, Inc.
    Inventors: Lawrence T. Boni, Andrew S. Janoff, Sharma R. Minchey, Walter R. Perkins, Christine E. Swenson, Patrick L. Ahl, Thomas S. Davis
  • Patent number: 5770222
    Abstract: Therapeutic drug delivery systems comprising gas-filled microspheres comprising a therapeutic are described. Methods for employing such microspheres in therapeutic drug delivery applications are also provided. Drug delivery systems comprising gas-filled liposomes having encapsulated therein a drug are preferred. Methods of and apparatus for preparing such liposomes and methods for employing such liposomes in drug delivery applications are also disclosed.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: June 23, 1998
    Assignee: ImaRx Pharmaceutical Corp.
    Inventors: Evan C. Unger, Thomas A. Fritz, Terry Matsunaga, VaradaRajan Ramaswami, David Yellowhair, Guanli Wu
  • Patent number: 5766627
    Abstract: A multivesicular liposome composition containing at least one acid other than a hydrohalic acid and at least one biologically active substance, the vesicles having defined size distribution, adjustable average size, internal chamber size and number, provides a controlled release rate of the biologically active substance from the composition. A process for making the composition features addition of a non-hydrohalic acid effective to sustain and control the rate of release of an encapsulated biologically active substance from the vesicles at therapeutic levels in vivo.
    Type: Grant
    Filed: May 23, 1997
    Date of Patent: June 16, 1998
    Assignee: Depotech
    Inventors: Mantripragada Bhima Sankaram, Sinil Kim
  • Patent number: 5762904
    Abstract: Polymerized liposomes, methods of preparing the polymerized liposomes and incorporating biologically active substances within the polymerized liposomes, and methods of administering polymerized liposomes containing a biologically active substance to be delivered to a patient are disclosed. The polymerized liposomes are prepared by polymerizing double bond-containing liposomes. The polymerization can be initiated with a source of radiation and/or a free radical initiator. Biologically active substances can be incorporated into both the hydrophilic and hydrophobic layers of the liposomes, either during or after polymerization. The polymerized liposomes can be administered orally to a patient in need of the biologically active substance to be delivered. Examples demonstrate enhanced stability.
    Type: Grant
    Filed: January 17, 1997
    Date of Patent: June 9, 1998
    Assignee: Massachusetts Institute of Technology
    Inventors: Junichi Okada, Smadar Cohen, Robert S. Langer
  • Patent number: 5738868
    Abstract: A method for preparing a radio labelled liposome, the method including the steps of at least once dehydrating and rehydrating a treated liposome to form a binding liposome, and adding a radio label to said binding liposome to form the radio labelled liposome.
    Type: Grant
    Filed: July 18, 1995
    Date of Patent: April 14, 1998
    Assignee: Lipogenics Ltd.
    Inventor: Leonid Lurya Shinkarenko