Over 60 To 62% Carbon Patents (Class 424/121)
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Patent number: 4209509Abstract: Substance SF-1739 derivatives, Substance SF-1739 HP, Substance SF-1739 HP-C, Substance SF-1739 HP-F, Substance SF-1739 HP-3 and Substance SF-1739 HP-5, the physico-chemical properties of which derivatives are described in the specification; processes for preparing such SF-1739 derivatives; and antimicrobial compositions containing at least one of the said Substance SF-1739 derivatives.Type: GrantFiled: February 1, 1979Date of Patent: June 24, 1980Assignee: Meiji Seika Kaisha Ltd.Inventors: Shigeharu Inouye, Takashi Shomura, Michio Kojima, Takashi Hisamatsu
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Patent number: 4191825Abstract: The present invention relates to diacyloxyacids derived from the antibiotic substance, designated acid S, produced by Polyangium cellulosum var. fulvum (ATCC No. 25532), and to processes for their production. The diacyloxyacids derivatives of acid S of this invention are useful as antifungal and antibacterial agents.Type: GrantFiled: October 5, 1978Date of Patent: March 4, 1980Assignee: Warner-Lambert CompanyInventors: David T. Connor, Samuel M. Ringel, Sidney Roemer, Maximillian von Strandtmann
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Patent number: 4169888Abstract: Novel antibiotic CC-1065 producible in a fermentation under controlled conditions using the new microorganism Streptomyces zelensis, NRRL 11,183. This antibiotic is active against Gram-positive bacteria, for example, Staphylococcus aureus, Bacillus subtilis, Streptococcus pyogenes, Sarcina lutea, and Streptococcus faecalis. It is also active against Gram-negative bacteria, for example, Escherichia coli, Proteus vulgaris, Pseudomonas aeruginosa, Klebsiella pneumoniae, and Salmonella pullorum. Thus, antibiotic CC-1065 can be used in various environments to eradicate or control such bacteria.Type: GrantFiled: October 17, 1977Date of Patent: October 2, 1979Assignee: The Upjohn CompanyInventors: Ladislav J. Hanka, David G. Martin
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Patent number: 4148880Abstract: A species of Actinoplanes, designated Actinoplanes auranticolor ATCC 31011, when subjected to submerged aerobic fermentation under controlled conditions, produces a mixture of antibiotics which includes a number of macrocyclic lactones and depsipeptides. The individual compounds exhibit significant antibiotic activity. The crude antibiotic mixture or combinations of a pure macrocyclic lactone and a pure depsipeptide demonstrate marked synergistic antibiotic activity. These antibiotics act as growth promotants in chicks and swine and are effective in the treatment of swine dysentery.This mixture of antibiotics is also produced by a species of Actinoplanes designated Actinoplanes azureus ATCC 31157. In addition, this culture produces a mixture of heptaene antibiotics with antifungal properties.Type: GrantFiled: December 16, 1976Date of Patent: April 10, 1979Assignee: Pfizer Inc.Inventors: Walter D. Celmer, Walter P. Cullen, Charles E. Moppett, John B. Routien, Riichiro Shibakawa, Junsuke Tone
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Patent number: 4148891Abstract: An antifungal preparation to be used in and on agricultural products such as fruit, vegetables, tubers, root-tubers, flower bulbs and rootstocks comprising an amount of polyene antibiotic, peferably natamycin, effective to prevent or inhibit mold growth on the agricultural products dissolved in a mixture of a lower alkanol, such as ethyl alcohol, and a lower alkanoic acid, such as acetic acid and agricultural products treated with this preparation and the method of treatment by submerging the agricultural products in the preparation or by pasting or spraying the preparation onto the agricultural products.Type: GrantFiled: March 6, 1978Date of Patent: April 10, 1979Assignee: Gist-Brocades N.V.Inventor: Dirk A. Smink
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Patent number: 4138550Abstract: The present invention relates to diacyloxyacids derived from the antibiotic substance, designated acid S, produced by Polyangium cellulosum var. fulvum (ATCC No. 25532), and to processes for their production. The diacyloxyacids derivatives of acid S of this invention are useful as antifungal and antibacterial agents.Type: GrantFiled: February 4, 1977Date of Patent: February 6, 1979Assignee: Warner-Lambert CompanyInventors: David T. Connor, Samuel M. Ringel, Sidney Roemer, Maximillian Von Strandtmann
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Patent number: 4133876Abstract: Antibiotic A-32887 is produced by submerged aerobic fermentation of Streptomyces albus NRRL 11109. A-32887 is an antibacterial, antiprotozoal, anticoccidial, and insecticidal agent. A-32887 also increases feed-utilization efficiency in ruminants.Type: GrantFiled: May 31, 1977Date of Patent: January 9, 1979Assignee: Eli Lilly and CompanyInventors: Robert L. Hamill, Marvin M. Hoehn
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Patent number: 4132778Abstract: Antibiotic A-32887 is produced by submerged aerobic fermentation of Streptomyces albus NRRL 11109. A-32887 is an antibacterial, antiprotozoal, anticoccidial, and insecticidal agent. A-32887 also increases feed-utilization efficiency in ruminants.Type: GrantFiled: October 3, 1977Date of Patent: January 2, 1979Assignee: Eli Lilly and CompanyInventors: Robert L. Hamill, Marvin M. Hoehn
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Patent number: 4127446Abstract: Antibiotic substances; mimosamycin having antibacterial activities and chlorocarcins A, B and C having antitumor activities, and these antibiotics are produced by cultivation of Streptomyces lavendulae strain No. 314.Type: GrantFiled: April 18, 1977Date of Patent: November 28, 1978Inventor: Tadashi Arai
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Patent number: 4123521Abstract: New antiobiotic U-53,946 produced by the controlled fermentation of the new microorganism Paecilomyces abruptus sp. nov., NRRL 11110. This antibiotic is active against Gram-positive bacteria, for example, Sarcina lutea, Staphylococcus aureus, Bacillus subtilis, Mycobacterium avium, and Streptococcus pyrogenes, and the yeast Saccharomyces pastorianus. Accordingly, they can be used in various environments to eradicate or control these microorganisms.Type: GrantFiled: April 22, 1977Date of Patent: October 31, 1978Assignee: The Upjohn CompanyInventors: Ladislav J. Hanka, Paul F. Wiley
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Patent number: 4107429Abstract: The present invention relates to 1-nor-2-amino carbamates derived from the antibiotic substance, designated acid S, produced by Polyangium cellulosum var. fulvum (ATCC No. 25532), and to processes for their production. The 1-nor-2-amino carbamates of acid S of this invention are useful as antifungal agents.Type: GrantFiled: February 4, 1977Date of Patent: August 15, 1978Assignee: Warner-Lambert CompanyInventors: David T. Connor, Samuel M. Ringel, Maximilian VON Strandtmann
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Patent number: 4107296Abstract: Antibiotic rubradirin C producible by the controlled fermentation of the known microorganism Streptomyces achromogenes var. rubradiris, NRRL 3061. This antibiotic and its base-addition salts are active against Streptococcus pyogenes and Bacillus cereus. Accordingly, they can be used in various environments to eradicate or control such microorganisms. SuBACKGROUND OF THE INVENTIONAntibiotic rubradirin, and a microbiological process for its preparation, are disclosed in U.S. Pat. No. 3,335,057. Rubradirin B is disclosed in U.S. application Ser. No. 787,833, filed Apr. 15, 1977. Degradation products of rubradirin and rubradirin B, and processes for their preparation are disclosed in U.S. application Ser. No. 793,785, filed May 5, 1977.BRIEF SUMMARY OF THE INVENTIONThe novel antibiotic of the invention, rubradirin C, is obtained by culturing Streptomyces achromogenes var. rubradiris, NRRL 3061, in an aqueous nutrient medium under aerobic conditions. The fermentation conditions disclosed in U.S. Pat. No.Type: GrantFiled: June 29, 1977Date of Patent: August 15, 1978Assignee: The Upjohn CompanyInventors: Herman Hoeksema, Fritz Reusser
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Patent number: 4098998Abstract: The present invention relates to aldehyde, oxime and phenylhydrazone derivatives of the novel antibiotic substance, acid S, produced by the organism Polyangium cellulosum var. fulvum (ATCC No. 25532) and to processes for their preparation. The aldehyde, oxime and phenylhydrazone derivatives of acid S of this invention are useful as antifungal agents.Type: GrantFiled: February 4, 1977Date of Patent: July 4, 1978Assignee: Warner-Lambert CompanyInventors: David T. Connor, Samuel M. Ringel, Maximillian Von Strandtmann
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Patent number: 4081531Abstract: Antibiotic substance is produced by cultivation of Streptomyces lavendulae strain No. 314.Type: GrantFiled: April 18, 1977Date of Patent: March 28, 1978Inventor: Tadashi Arai
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Patent number: 4076940Abstract: A process for the conversion of the major antifungal antibiotic, acid S (ATCC NO. 25532) isolated from the fermentation of Polyangium cellulosum var. fulvum into the minor antibiotic, acid F, from the same fermentation is described wherein acid S is methylated with diazomethane to provide acid S methyl ester which is then oxidized with silver carbonate on celite to obtain the corresponding keto ester S, which is subsequently reduced with sodium borohydride to give a mixture of acid S methyl ester and acid F methyl ester. These esters are readily separated by preparative thin layer chromatography and the acid F methyl ester is hydrolyzed with sodium hydroxide solution to provide acid F.Type: GrantFiled: May 5, 1977Date of Patent: February 28, 1978Assignee: Warner-Lambert CompanyInventors: David T. Connor, Maximilian VON Strandtmann
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Patent number: 4069316Abstract: This invention provides a method for producing Antibiotic T-42082 wherein the method comprises cultivating an Antibiotic T-42082-producing strain of the genus Streptomyces (ATCC 31080) to permit said strain to elaborate and accumulate Antibiotic T-42082 in the resultant broth and harvesting the antibiotic from said broth. This invention also includes the novel antibiotic.Type: GrantFiled: November 1, 1976Date of Patent: January 17, 1978Assignee: Takeda Chemical Industries, Ltd.Inventors: Akira Imada, Yukimasa Nozaki, Toru Hasegawa, Masahiko Yoneda
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Patent number: 4038383Abstract: A species of Actinoplanes, designated Actinoplanes auranticolor ATCC 31011, when subjected to submerged aerobic fermentation under controlled conditions, produces a mixture of antibiotics which includes a number of macrocyclic lactones and depsipeptides. The individual compounds exhibit significant antibiotic activity. The crude antibiotic mixture or combinations of a pure macrocyclic lactone and a pure depsipeptide demonstrate marked synergistic antibiotic activity. These antibiotics act as growth promotants in chicks and swine and are effective in the treatment of swine dysentery.This mixture of antibiotics is also produced by a species of Actinoplanes designated Actinoplanes azureus ATCC 31157. In addition, this culture produces a mixture of heptaene antibiotics with antifungal properties.Type: GrantFiled: August 13, 1975Date of Patent: July 26, 1977Assignee: Pfizer Inc.Inventors: Walter D. Celmer, Walter P. Cullen, Charles E. Moppet, John B. Routien, Riichiro Shibakawa, Junsuke Tone
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Patent number: 4032631Abstract: A new species of Micromonospora, designated Micromonospora saitamica sp. nov. Routien, when subjected to submerged aerobic fermentation, produces at least four antibiotics. One of these is previously reported rubradirin produced by Streptomyces achromogenes var. rubradiris NRRL 3061.Type: GrantFiled: December 19, 1975Date of Patent: June 28, 1977Assignee: Pfizer Inc.Inventors: Walter D. Celmer, Walter P. Cullen, Charles E. Moppett, John R. Oscarson, John B. Routien, Riichiro Shibakawa, Junsuke Tone
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Patent number: 4032632Abstract: Two new species of Streptosporangium, designated Streptosporangium koreanum Routien sp. nov. and Streptosporangium cinnabarinum Routien sp. nov., when subjected to submerged aerobic fermentation, produce the same two new antibiotics. Methods for the recovery and purification of these antibiotics, co-produced with minor antibiotics, are described and some of their antimicrobial properties are outlined.Type: GrantFiled: July 23, 1976Date of Patent: June 28, 1977Assignee: Pfizer Inc.Inventors: Walter D. Celmer, Walter P. Cullen, Charles E. Moppett, John B. Routien, Mark T. Jefferson, Riichiro Shibakawa, Junsuke Tone
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Patent number: 4016256Abstract: A prophylactic and therapeutic composition effective in the treatment of coccidiomycosis and including a new antibiotic known as TS-0822.Type: GrantFiled: November 19, 1975Date of Patent: April 5, 1977Assignee: Kayaku Antibiotic Research Co., Ltd.Inventors: Nakao Ishida, Fumio Kitame, Kuniko Utsushikawa, Tomoaki Kohama, Takuya Saito, Mikio Kikuchi
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Patent number: 4012284Abstract: 1. A process for the preparation of a new antibiotic F.I. 1762, which comprises cultivating the Streptomyces 1762 under aerobic conditions in a liquid nutrient medium containing a carbon source, a nitrogen source and mineral salts, at a temperature between 25.degree. and 37.degree. C, over a period of time from 3 to 7 days, and extracting the formed antibiotic from the fermentation broth at a pH between 8 and 9 by means of a water-immiscible solvent, isolating and purifying the antibiotic F.I. 1762.Type: GrantFiled: October 6, 1964Date of Patent: March 15, 1977Assignee: Societa' Farmaceutici Italia, S.p.A.Inventors: Aurelio Di Marco, Graziana Canevazzi, Arpad Grein, Piergiuseppe Orezzi, Marcello Gaetani
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Patent number: 4009261Abstract: The present invention relates to 7-substituted triol derivatives of the novel antibiotic substance, acid S, produced by the organism Polyangium cellulosum var. fulvum (ATCC No. 25532) and to processes for their preparation. The 7-substituted triol derivatives of acid S of this invention are useful as antifungal agents.Type: GrantFiled: August 7, 1975Date of Patent: February 22, 1977Assignee: Warner-Lambert CompanyInventors: David T. Connor, Samuel M. Ringel, Maximilian VON Strandtmann
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Patent number: 4001399Abstract: Alkanoyl-josamycins having no bitter taste, in which at least one of the two secondary hydroxyl groups of Josamycin is acylated (introduction of alkanoyl group).Type: GrantFiled: May 23, 1975Date of Patent: January 4, 1977Assignee: Yamanouchi Pharmaceutical Co., Ltd.Inventors: Takashi Osono, Kiruko Moriyama, Keisuke Murakami, Hamao Umezawa
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Patent number: 3978210Abstract: A family of antibiotics active against pathogenic yeasts and fungi comprises aculeacin-A, -B, -C, -D, -E, -F, and -G. These are produced from cultured broth of Aspergillus aculeatus FERM-P 2324.Type: GrantFiled: March 6, 1975Date of Patent: August 31, 1976Assignee: Toyo Jozo Kabushiki KaishaInventors: Kimio Mizuno, Tetsuo Matsuda, Katsumi Asano, Akira Yagi, Masaki Takada, Tetsu Saito, Minoru Toriya, Shuzo Satoi, Kazuo Matsuura
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Patent number: 3968204Abstract: Antibiotic A-2315 mixture, comprising microbiologically active, structurally related factors A, B, and C, produced by culturing Actinoplanes philippinensis NRRL 5462 under submerged aerobic fermentation conditions. Individual factors A, B, and C are separated and isolated by chromatographic procedures. The A-2315 antibiotics are useful in controlling the growth of cariogenic organisms, in promoting the growth of chickens, and in increasing feed-utilization efficiency in ruminants.Type: GrantFiled: April 28, 1975Date of Patent: July 6, 1976Assignee: Eli Lilly and CompanyInventors: Robert L. Hamill, William Max Stark
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Patent number: 3961047Abstract: The present invention provides new esters of partricin and of N-substituted derivatives of partricin.Type: GrantFiled: February 13, 1974Date of Patent: June 1, 1976Assignee: SPA-Societa Prodotti Antibiotici S.p.A.Inventors: Tiberio Bruzzese, Giuseppe Ghielmetti
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Patent number: 3950514Abstract: A new polyether group antibiotic, TM-481, having the estimated empirical formula C.sub.42-45 H.sub.71-75 O.sub.14-15 Na and possessing an antibacterial activity against pathogenic microorganisms, particularly Gram-positive bacteria is obtained by culturing a TM-481 producing microorganism of the Streptomyces ribosidificus group in a nutrient medium therefor.Type: GrantFiled: September 4, 1974Date of Patent: April 13, 1976Assignee: Taisho Pharmaceutical Co., Ltd.Inventors: Jiro Sawada, Sadafumi Omura, Michinori Shibata, Sadao Machida
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Patent number: RE30339Abstract: A process for the conversion of the major antifungal antibiotic, acid S (ATCC No. 25532) isolated from the fermentation of Polyangium cellulosum var. fulvum into the minor antibiotic, acid F, from the same fermentation is described wherein acid S is methylated with diazomethane to provide acid S methyl ester which is then oxidized with silver carbonate on celite to obtain the corresponding keto ester S, which is subsequently reduced with sodium borohydride to give a mixture of acid S methyl ester and acid F methyl ester. These esters are readily separated by preparative thin layer chromatography and the acid F methyl ester is hydrolyzed with sodium hydroxide solution to provide acid F.Type: GrantFiled: July 14, 1978Date of Patent: July 15, 1980Assignee: Warner-Lambert CompanyInventors: David T. Connor, Maximilian von Strandtmann